TW202300143A - 靶向成纖維細胞活化蛋白之化合物及其使用方法 - Google Patents

靶向成纖維細胞活化蛋白之化合物及其使用方法 Download PDF

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TW202300143A
TW202300143A TW111109356A TW111109356A TW202300143A TW 202300143 A TW202300143 A TW 202300143A TW 111109356 A TW111109356 A TW 111109356A TW 111109356 A TW111109356 A TW 111109356A TW 202300143 A TW202300143 A TW 202300143A
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compound
radiotherapy
group
magnetic resonance
radioimaging
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TW111109356A
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飛利浦 史都華 婁
拉梅什 穆卡馬拉
馬杜里 斯里尼瓦薩拉奧
斯班瑟 D 林德曼
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普渡研究基金會
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/08Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08Bridged systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/10Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10Spiro-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
TW111109356A 2021-03-16 2022-03-15 靶向成纖維細胞活化蛋白之化合物及其使用方法 TW202300143A (zh)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US202163200592P 2021-03-16 2021-03-16
US202163161835P 2021-03-16 2021-03-16
US202163200593P 2021-03-16 2021-03-16
US63/200,592 2021-03-16
US63/161,835 2021-03-16
US63/200,593 2021-03-16
US202163165550P 2021-03-24 2021-03-24
US202163165563P 2021-03-24 2021-03-24
US202163165583P 2021-03-24 2021-03-24
US63/165,563 2021-03-24
US63/165,583 2021-03-24
US63/165,550 2021-03-24
WOPCT/US22/20084 2022-03-12
PCT/US2022/020084 WO2022197567A1 (en) 2021-03-16 2022-03-12 Compounds targeting fibroblast-activation protein and methods of use thereof

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TW202300143A true TW202300143A (zh) 2023-01-01

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US (1) US20240238458A1 (https=)
EP (1) EP4308110A4 (https=)
JP (1) JP2024510267A (https=)
CA (1) CA3212210A1 (https=)
TW (1) TW202300143A (https=)
WO (1) WO2022197567A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI879182B (zh) * 2023-10-26 2025-04-01 國家原子能科技研究院 白蛋白雙重結合功能之纖維母細胞活化蛋白化合物或其鹽
WO2025155818A1 (en) * 2024-01-19 2025-07-24 Purdue Research Foundation Fibroblast activation protein-targeted radioligands with pharmacokinetic modulators
WO2025171343A1 (en) * 2024-02-08 2025-08-14 Immunome, Inc. Compounds targeting fibroblast-activation protein and methods of use thereof
CN118593732B (zh) * 2024-06-27 2025-03-11 华中科技大学同济医学院附属同济医院 一种心肌炎核素分子探针及其制备方法和应用

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* Cited by examiner, † Cited by third party
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EP1943257A2 (en) * 2005-05-19 2008-07-16 Genentech, Inc. Fibroblast activation protein inhibitor compounds and methods
US8071787B2 (en) * 2009-03-13 2011-12-06 National Health Research Institutes Pyrrolidine compounds
JP6744826B2 (ja) * 2014-06-13 2020-08-19 バック バイオサイエンシーズ, エルエルシーBach BioSciences, LLC Fap活性化治療剤及びそれに関連する使用
CN116474108A (zh) * 2016-12-14 2023-07-25 普渡研究基金会 成纤维细胞活化蛋白(fap)-靶向成像和治疗
JP7094591B2 (ja) * 2018-03-30 2022-07-04 フューチャーケム カンパニー リミテッド 前立腺がんを診断および処置するためのpsma標的放射性医薬品
US11426472B2 (en) * 2018-10-17 2022-08-30 Purdue Research Foundation Fibroblast activation protein (FAP) targeted imaging and therapy in fibrosis
EP3946320A4 (en) * 2019-04-03 2022-12-28 Tva (Abc), Llc CONJUGATES RELATED TO HSP90 AND FORMULATIONS THEREOF
WO2021016392A1 (en) * 2019-07-22 2021-01-28 Purdue Research Foundation Multivalent fibroblast-targeted agents and methods of use

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US20240238458A1 (en) 2024-07-18
EP4308110A4 (en) 2025-06-18
JP2024510267A (ja) 2024-03-06
WO2022197567A1 (en) 2022-09-22
EP4308110A1 (en) 2024-01-24
CA3212210A1 (en) 2022-09-22

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