TW202300143A - 靶向成纖維細胞活化蛋白之化合物及其使用方法 - Google Patents
靶向成纖維細胞活化蛋白之化合物及其使用方法 Download PDFInfo
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
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- Proteomics, Peptides & Aminoacids (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
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Applications Claiming Priority (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163200592P | 2021-03-16 | 2021-03-16 | |
| US202163161835P | 2021-03-16 | 2021-03-16 | |
| US202163200593P | 2021-03-16 | 2021-03-16 | |
| US63/200,592 | 2021-03-16 | ||
| US63/161,835 | 2021-03-16 | ||
| US63/200,593 | 2021-03-16 | ||
| US202163165550P | 2021-03-24 | 2021-03-24 | |
| US202163165563P | 2021-03-24 | 2021-03-24 | |
| US202163165583P | 2021-03-24 | 2021-03-24 | |
| US63/165,563 | 2021-03-24 | ||
| US63/165,583 | 2021-03-24 | ||
| US63/165,550 | 2021-03-24 | ||
| WOPCT/US22/20084 | 2022-03-12 | ||
| PCT/US2022/020084 WO2022197567A1 (en) | 2021-03-16 | 2022-03-12 | Compounds targeting fibroblast-activation protein and methods of use thereof |
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| TW202300143A true TW202300143A (zh) | 2023-01-01 |
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| TW (1) | TW202300143A (https=) |
| WO (1) | WO2022197567A1 (https=) |
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| TWI879182B (zh) * | 2023-10-26 | 2025-04-01 | 國家原子能科技研究院 | 白蛋白雙重結合功能之纖維母細胞活化蛋白化合物或其鹽 |
| WO2025155818A1 (en) * | 2024-01-19 | 2025-07-24 | Purdue Research Foundation | Fibroblast activation protein-targeted radioligands with pharmacokinetic modulators |
| WO2025171343A1 (en) * | 2024-02-08 | 2025-08-14 | Immunome, Inc. | Compounds targeting fibroblast-activation protein and methods of use thereof |
| CN118593732B (zh) * | 2024-06-27 | 2025-03-11 | 华中科技大学同济医学院附属同济医院 | 一种心肌炎核素分子探针及其制备方法和应用 |
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| EP1943257A2 (en) * | 2005-05-19 | 2008-07-16 | Genentech, Inc. | Fibroblast activation protein inhibitor compounds and methods |
| US8071787B2 (en) * | 2009-03-13 | 2011-12-06 | National Health Research Institutes | Pyrrolidine compounds |
| JP6744826B2 (ja) * | 2014-06-13 | 2020-08-19 | バック バイオサイエンシーズ, エルエルシーBach BioSciences, LLC | Fap活性化治療剤及びそれに関連する使用 |
| CN116474108A (zh) * | 2016-12-14 | 2023-07-25 | 普渡研究基金会 | 成纤维细胞活化蛋白(fap)-靶向成像和治疗 |
| JP7094591B2 (ja) * | 2018-03-30 | 2022-07-04 | フューチャーケム カンパニー リミテッド | 前立腺がんを診断および処置するためのpsma標的放射性医薬品 |
| US11426472B2 (en) * | 2018-10-17 | 2022-08-30 | Purdue Research Foundation | Fibroblast activation protein (FAP) targeted imaging and therapy in fibrosis |
| EP3946320A4 (en) * | 2019-04-03 | 2022-12-28 | Tva (Abc), Llc | CONJUGATES RELATED TO HSP90 AND FORMULATIONS THEREOF |
| WO2021016392A1 (en) * | 2019-07-22 | 2021-01-28 | Purdue Research Foundation | Multivalent fibroblast-targeted agents and methods of use |
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- 2022-03-12 EP EP22771974.7A patent/EP4308110A4/en active Pending
- 2022-03-12 WO PCT/US2022/020084 patent/WO2022197567A1/en not_active Ceased
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- 2022-03-12 CA CA3212210A patent/CA3212210A1/en active Pending
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| US20240238458A1 (en) | 2024-07-18 |
| EP4308110A4 (en) | 2025-06-18 |
| JP2024510267A (ja) | 2024-03-06 |
| WO2022197567A1 (en) | 2022-09-22 |
| EP4308110A1 (en) | 2024-01-24 |
| CA3212210A1 (en) | 2022-09-22 |
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