TW202245911A - Manufacturing method of hydrophilic film structure for biochemical detection sheet and product thereof - Google Patents

Abstract

A manufacturing method of hydrophilic film structure for biochemical detection sheet includes a) providing a backing tape including an adhesive layer, a first release paper and a second release paper, the first surface of the adhesive layer being combined with the first release paper, and the second surface being combined with the second release paper; b) punching the backing tape to form a plurality of runner holes, and removing the first release paper; c) providing a hydrophilic film and attach it to the first surface; d) performing the printing to the hydrophilic film and forming the testing pattern; e) cutting the waste area outside the testing pattern and keeping the second release paper, and removing the adhesive tape and hydrophilic film in the waste area; and f) cutting the second release paper and the adhesive tape to form a hydrophilic film structure with a single testing pattern. Thereby, a fast and precise hydrophilic membrane structure is provided.

Description

Method for manufacturing hydrophilic membrane structure used for biochemical detection sheet and its finished product

The invention relates to a biochemical detection device, in particular to a method for manufacturing a hydrophilic membrane structure of a biochemical detection sheet and its finished product.

The biochemical detection device is used to obtain the physiological information of the analyte as a reference for analyzing the analyte. Most of the current biosensor test strips are provided with a detection opening and a detection flow channel on the plastic plate, so that the substance to be detected drops into the detection opening and flows into the detection flow channel, and then measures the sample and obtains relevant data.

Furthermore, the biosensing test piece is provided with a resistance element and a hydrophilic film. The hydrophilic film is made of hydrophilic material, which is arranged in the reaction area of the biological sensing test piece and covers the resistance parts, so as to strengthen the capillary action of the inner wall of the reaction area. In addition, the hydrophilic membrane is set corresponding to the position of the resistance part, the detection opening and the detection flow channel of the biosensor test piece. In this regard, how to provide a fast and precise hydrophilic membrane structure to cover the biosensor test piece is the motivation of the inventors.

In view of this, the inventor of the present invention aimed at the above-mentioned prior art, devoted himself to research and combined with the application of theories, and tried his best to solve the above-mentioned problems, which became the goal of the inventor's improvement.

One object of the present invention is to provide a method for manufacturing a hydrophilic membrane structure for a biochemical detection chip, so as to provide a hydrophilic membrane structure that can be fabricated quickly and with precise structure.

In order to achieve the above object, the present invention is a method for manufacturing a hydrophilic membrane structure for a biochemical detection sheet, comprising: a) providing a back-adhesive tape, including an adhesive layer, a first release paper and a second release paper, the adhesive layer It has opposite first surface and second surface, the first surface is combined with the first release paper, and the second surface is combined with the second release paper; b) punching the back-adhesive tape to form corresponding to the structure of the biochemical detection sheet A plurality of channel holes, and remove the first release paper; c) provide a hydrophilic film, and attach the hydrophilic film to the first surface; d) print the hydrophilic film and form a plurality of test piece graphics, these test piece graphics are Corresponding to the structural setting of the biochemical test piece; e) performing the first cut, cutting the waste area outside the test piece pattern and retaining the second release paper, and removing the adhesive tape and hydrophilic film in the waste area; and f) Carrying out the second cutting, cutting the second release paper and the adhesive tape to separate the pattern of the test piece on the hydrophilic film and form a hydrophilic film structure with a single pattern of the test piece.

Compared with the conventional ones, the production process of the hydrophilic membrane structure of the present invention is to provide a back-adhesive tape laminated with the first release paper, the adhesive layer and the second release paper, and punch holes to form a plurality of flow channel holes, and Remove the first release paper; then, attach the hydrophilic film to the adhesive layer, print the hydrophilic film and form a test piece pattern, continue to cut the waste area and keep the second release paper, and finally print the second release paper The type paper and adhesive tape are cut for the second time to form a hydrophilic film structure with a single detection pattern.

The detailed description and technical content of the present invention are described below with the drawings, but the attached drawings are only for reference and description, and are not used to limit the present invention.

Please refer to FIG. 1 to FIG. 3 , which are the flow chart of the method for manufacturing the hydrophilic membrane structure of the biochemical detection chip, the three-dimensional exploded schematic diagram of the biochemical detection chip, and the top view of the biochemical detection chip, respectively. As shown in FIG. 1 , the present invention provides a method for manufacturing a hydrophilic membrane structure 1 . Also, please refer to Fig. 2 and Fig. 3, the hydrophilic membrane structure 1 is used for a biochemical detection sheet 2, and the biochemical detection sheet 2 is provided with a convex seat 3, a plurality of detection flow channels 4 and SMT for setting resistance parts, etc. Part hole 5 etc. The hydrophilic membrane structure 1 is set corresponding to the structure of the biochemical detection chip 2 and is used to fit on the biochemical detection chip 2 to cover the detection channels 4 and expose the protrusion 3 . The manufacturing method of the hydrophilic membrane structure 1 is described in detail below.

Please refer to Fig. 4 and Fig. 5, which are the sectional view and the top view of the adhesive tape combined with the release paper of the present invention. The manufacturing method of the hydrophilic film structure of the present invention includes: a) providing an adhesive tape 10 including an adhesive layer 11 , a first release paper 12 and a second release paper 13 . The adhesive layer 11 has a first surface 111 and a second surface 112 opposite to each other. The first surface 111 is combined with a first release paper 12 . The second surface 112 is combined with the second release paper 13 . Also, in step a), the adhesive tape 10 is provided with a plurality of process electric eye marks 100, and the setting of these process electric eye marks 100 can be used for positioning and correction through electric eyes in subsequent processes. In this embodiment, the process electric eye marks 100 are a plurality of through holes.

Please also refer to FIG. 6 to FIG. 8 , which are the top view, partial enlarged schematic diagram and partial cross-sectional view of the adhesive tape of the present invention after punching. As shown in Figure 6, the manufacturing method of the hydrophilic membrane structure 1 of the present invention includes: b) punching the adhesive tape 10 to form a plurality of flow channel holes 101 corresponding to the structure of the biochemical detection sheet 2, and then removing The first release paper 12.

It should be noted that, in step b), the adhesive tape 10 is additionally formed with a plurality of alignment holes 102 . The alignment holes 102 are formed with the flow channel holes 101 through a punching process. More specifically, the alignment holes 102 include a machine positioning hole 1021 for positioning the machine and a test strip positioning hole 1022 for positioning the biochemical testing strip 3 .

Please refer to FIG. 9 again, which is a cross-sectional view of the adhesive tape combined with the hydrophilic film of the present invention. The manufacturing method of the hydrophilic membrane structure 1 of the present invention also includes: c) providing a hydrophilic membrane 20, and attaching the hydrophilic membrane 20 to the first layer of the first release paper 12 (referring to FIG. 8 ) where the adhesive layer 11 has been removed. Surface 111.

It should be noted that, in the manufacturing method of the hydrophilic membrane structure 1 of the present invention, the raw materials of the adhesive tape 10 and the hydrophilic membrane 20 are arranged in a roll shape, and are carried out in the form of a tape during the manufacturing process.

Please continue to refer to Fig. 10 to Fig. 12, which are the top view, partially enlarged schematic diagram and partial cross-sectional view of the pattern of the printed test piece of the hydrophilic film of the present invention. The manufacturing method of the hydrophilic membrane structure 1 of the present invention includes: d) printing the hydrophilic membrane 20 to form a plurality of test strip patterns 30, and these test strip patterns 30 are set corresponding to the structure of the biochemical detection strip 2. In this embodiment, the test piece patterns 30 are blue layers corresponding to the places outside the channel holes 101 .

It should be noted that, in this embodiment, the adhesive tape 10 has an extending direction 300 . In addition, the test strip patterns 30 have a first side 301 perpendicular to the extending direction 300 and a second side 302 parallel to the extending direction 300 . Also, in the step d), the test piece patterns 30 include a plurality of air hole positions 303 .

Please refer to Fig. 13 to Fig. 15 again, which are the top view, partially enlarged schematic diagram and partial cross-sectional view of the first cutting of the hydrophilic membrane of the present invention. The manufacturing method of the hydrophilic membrane structure 1 of the present invention includes: e) cutting for the first time, cutting a waste area 31 outside the test piece patterns 30 and keeping the second release paper 13, and removing the The adhesive tape 10 and the hydrophilic film 20 in the waste area 31 . Moreover, in step e), the first sides 301 of the test piece patterns 30 are cut.

In this embodiment, the test strip patterns 30 are arranged at intervals and a plurality of first waste areas 311 are formed; in addition, a plurality of second waste areas 312 are formed between the test strip patterns 30 and the marks 100 . In step e), the waste area 31 includes the first waste areas 311 and the second waste areas 312 .

Please refer to Fig. 16 to Fig. 18 at the same time, which are the top view, partial enlarged schematic diagram and partial cross-sectional view of the waste area after the first cutting of the hydrophilic film of the present invention. Further, in the e) step, only the adhesive layer 11 and the hydrophilic film 20 in the waste area 31 are cut, and the second release paper 13 is retained to make the test pieces on the hydrophilic film 20 Graphics 30 remain continuous without separation.

Please continue to refer to Fig. 19 to Fig. 21, which are the top view, partial enlarged schematic diagram and partial cross-sectional view of the hydrophilic membrane of the present invention after the second cutting to remove the waste area. The manufacturing method of the hydrophilic membrane structure 1 of the present invention further includes: f) performing a second cutting, cutting the second release paper 13 and the adhesive tape 10 to separate each of the test piece patterns 30 on the hydrophilic membrane 20 , and form a hydrophilic membrane structure 1 with a single test piece pattern 30.

It should be noted that in the step f), the second sides 302 of the test strip patterns 30 are cut according to the appearance of the biochemical test strip 2 . In addition, the step f) further includes corresponding alignment holes 102 (including machine positioning holes 1021 for positioning the machine and test piece positioning holes 1022 for positioning the biochemical test strip 3 ) on the hydrophilic membrane 20 . position for punching. In addition, step f) also includes punching holes on the hydrophilic membrane 20 corresponding to the air hole positions 303 .

Accordingly, the present invention completes the hydrophilic membrane structure 1 according to the aforementioned manufacturing method. The hydrophilic membrane structure 1 is used for a biochemical detection sheet 2 (refer to FIG. 2 ), and includes an adhesive layer 11 , a hydrophilic membrane 20 and a release paper (second release paper 13 ). The adhesive layer 11 has a first surface 111 and a second surface 112 opposite to each other.

Moreover, the hydrophilic film 20 is attached to the first surface 111 , and the hydrophilic film 20 is printed with a test strip pattern 30 corresponding to the structure of the biochemical testing strip 2 .

Furthermore, the release paper (second release paper 13 ) is attached to the second surface 112 . The release paper and the adhesive layer 11 constitute a back adhesive tape 10 . The back-adhesive strip 10 forms a plurality of channel holes 101 corresponding to the structure of the biochemical detection chip 2 .

In addition, it should be noted that after the hydrophilic membrane structure 1 of the present invention is manufactured, it will be visually inspected through a monitoring camera (CCD) to confirm that the manufactured product meets the specifications. After confirming that the product is correct, the second release paper 13 of the hydrophilic film structure 1 is then torn off to expose the adhesive layer 11 and the hydrophilic film 20 attached to the adhesive layer 11 (printed with a single test piece pattern 30 ). Thereby, the hydrophilic membrane 20 can be adhered to the biochemical detection chip 2 by using the adhesive layer 11 .

The above descriptions are only preferred embodiments of the present invention, and are not used to define the patent scope of the present invention. Other equivalent changes using the patent spirit of the present invention should all belong to the patent scope of the present invention.

1: Hydrophilic membrane structure

2: Biochemical test piece

3: convex seat

4: Check the flow channel

5: SMT part hole

10: Adhesive tape

100: process electric eye mark

101: runner hole

102: Alignment hole

1021: Machine positioning hole

1022: Test piece positioning hole

11: Adhesive layer

111: first surface

112: second surface

12: The first release paper

13: Second release paper

20: Hydrophilic membrane

30: Test piece graphics

300: Extension direction

301: first side

302: second side

303: Stomatal position

31: waste area

311: The first waste area

312: second waste area

a~f: steps

Fig. 1 is a schematic flow chart of the method for manufacturing the hydrophilic membrane structure of the biochemical detection sheet according to the present invention.

Fig. 2 is a three-dimensional exploded schematic view of the biochemical detection sheet of the present invention.

Fig. 3 is a top view of the biochemical detection sheet of the present invention.

Fig. 4 is a cross-sectional view of the adhesive tape of the present invention combined with release paper.

Fig. 5 is a top view of the adhesive tape of the present invention combined with the release paper.

Fig. 6 is a top view of the adhesive tape of the present invention after punching.

Fig. 7 is a partially enlarged schematic diagram of the adhesive tape of the present invention after punching.

Fig. 8 is a partial cross-sectional view of the adhesive tape of the present invention after punching.

Fig. 9 is a cross-sectional view of the adhesive tape of the present invention combined with a hydrophilic film.

Fig. 10 is the top view of the pattern of the printed test piece of the hydrophilic membrane of the present invention.

Fig. 11 is a partial enlarged schematic diagram of the pattern of the printed test piece of the hydrophilic membrane of the present invention.

Fig. 12 is a partial cross-sectional view of the pattern of the printed test piece of the hydrophilic film of the present invention.

Fig. 13 is the top view of the first cut of the hydrophilic membrane of the present invention.

Fig. 14 is a partially enlarged schematic diagram of the first cutting of the hydrophilic membrane of the present invention.

Fig. 15 is a partial sectional view of the first cutting of the hydrophilic membrane of the present invention.

Fig. 16 is a top view of the hydrophilic membrane of the present invention after the first cutting with the waste area removed.

Fig. 17 is a partially enlarged schematic diagram of removing the waste area after the first cutting of the hydrophilic membrane of the present invention.

Fig. 18 is a partial cross-sectional view of the hydrophilic membrane of the present invention after the first cut to remove the waste area.

Fig. 19 is a top view of the hydrophilic membrane of the present invention after the second cutting to remove the waste area.

Fig. 20 is a partially enlarged schematic diagram of removing the waste area after the second cutting of the hydrophilic membrane of the present invention.

Fig. 21 is a partial cross-sectional view of the hydrophilic membrane of the present invention after the second cutting to remove the waste area.

a~f: steps

Claims (10)

A method for manufacturing a hydrophilic membrane structure for a biochemical detection sheet, comprising: a) Provide a back adhesive tape, including an adhesive layer, a first release paper and a second release paper, the adhesive layer has a first surface and a second surface opposite, the first surface is combined with the first release paper A release paper, the second surface is combined with the second release paper; b) punching the adhesive tape to form a plurality of flow channel holes corresponding to the structure of the biochemical detection sheet, and removing the first release paper; c) providing a hydrophilic membrane, and attaching the hydrophilic membrane to the first surface; d) Printing the hydrophilic film and forming a plurality of test piece graphics, these test piece graphics are corresponding to the structural settings of the biochemical detection piece; e) Carry out the first cutting, cut a waste area outside the test piece graphics and keep the second release paper, and remove the adhesive tape and the hydrophilic film in the waste area; and f) Carrying out the second cutting, cutting the second release paper and the adhesive tape to separate each of the test piece patterns on the hydrophilic film, and forming a hydrophilic film structure with a single test piece pattern. The manufacturing method for the hydrophilic film structure of the biochemical detection sheet as described in claim 1, wherein in step a), the adhesive tape is provided with multiple process electric eye marks, and these process electric eye marks are used for d) Print jobs in steps. The manufacturing method for the hydrophilic membrane structure of the biochemical detection sheet as described in claim 1, wherein in step b), the adhesive tape is additionally formed with a plurality of alignment holes, and these alignment holes are connected with the flow channels. The holes are formed by punching. The manufacturing method for the hydrophilic membrane structure of the biochemical detection sheet as described in claim 3, wherein in step b), the alignment holes include machine positioning holes for machine positioning and for the biochemical detection sheet Locating test piece positioning holes. The manufacturing method for the hydrophilic membrane structure of the biochemical detection sheet as described in claim 1, wherein the adhesive tape has an extending direction, and the test strip patterns have a first side perpendicular to the extending direction and parallel to the For a second side in the extending direction, the first side is trimmed in step e), and the second side is trimmed in step f). The manufacturing method for the hydrophilic membrane structure of the biochemical detection sheet as described in claim 2, wherein the test sheet patterns are arranged at intervals and a plurality of first waste areas are formed, between the test strip patterns and the marks A plurality of second waste areas are formed, and in step e), the waste areas include the first waste areas and the second waste areas. The manufacturing method of the hydrophilic membrane structure used for the biochemical detection sheet as described in claim 3, wherein in the step f), it includes cutting the positions corresponding to the alignment holes on the hydrophilic membrane. The manufacturing method of the hydrophilic membrane structure used for the biochemical detection sheet as described in claim 3, wherein in the step f), it includes cutting the positions corresponding to the alignment holes on the hydrophilic membrane. The manufacturing method of the hydrophilic membrane structure used in the biochemical detection sheet as described in Claim 1, wherein the adhesive tape and the hydrophilic membrane are arranged in a roll shape. A kind of hydrophilic membrane structure for biochemical detection sheet, comprising: A glue layer has a first surface and a second surface opposite; A hydrophilic membrane attached to the first surface, the hydrophilic membrane is printed with a test strip pattern corresponding to the structure of the biochemical detection strip; and A release paper is attached to the second surface, and the release paper and the adhesive layer constitute a back adhesive tape, and the back adhesive tape forms a plurality of flow channel holes corresponding to the structure of the biochemical detection chip.

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