TW202237589A - 經取代的吡唑并哌啶羧酸 - Google Patents

經取代的吡唑并哌啶羧酸 Download PDF

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Publication number
TW202237589A
TW202237589A TW110146019A TW110146019A TW202237589A TW 202237589 A TW202237589 A TW 202237589A TW 110146019 A TW110146019 A TW 110146019A TW 110146019 A TW110146019 A TW 110146019A TW 202237589 A TW202237589 A TW 202237589A
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Taiwan
Prior art keywords
compound
diseases
formula
present
compounds
Prior art date
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TW110146019A
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English (en)
Chinese (zh)
Inventor
亞歷山大 瓦卡洛普洛斯
克羅佩林 瑪麗 皮埃爾 科林
紐瑞亞 奧特加埃爾南德斯
安德烈 迪斯考
梅麗莎 鮑塔達基斯阿拉皮尼斯
麗莎 坎迪舍
蒂莫 斯特爾菲德
伊爾卡 瑪塔
盧卡斯 霍夫邁斯特
彼得 桑德納
法蘭克 烏德
麗莎 迪茨
羅伯特 韋伯斯特
卡斯騰 施梅克
湯瑪士 蒙德里茨基
Original Assignee
德商拜耳廠股份有限公司
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Application filed by 德商拜耳廠股份有限公司 filed Critical 德商拜耳廠股份有限公司
Publication of TW202237589A publication Critical patent/TW202237589A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW110146019A 2020-12-10 2021-12-09 經取代的吡唑并哌啶羧酸 TW202237589A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20213020.9 2020-12-10
EP20213020 2020-12-10

Publications (1)

Publication Number Publication Date
TW202237589A true TW202237589A (zh) 2022-10-01

Family

ID=73793025

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110146019A TW202237589A (zh) 2020-12-10 2021-12-09 經取代的吡唑并哌啶羧酸

Country Status (31)

Country Link
US (1) US20240051935A1 (enExample)
EP (1) EP4259617B1 (enExample)
JP (1) JP2023552583A (enExample)
KR (1) KR20230118144A (enExample)
CN (1) CN116710439A (enExample)
AR (1) AR124297A1 (enExample)
AU (1) AU2021393988A1 (enExample)
CA (1) CA3204495A1 (enExample)
CL (1) CL2023001632A1 (enExample)
CO (1) CO2023007335A2 (enExample)
CR (1) CR20230242A (enExample)
DK (1) DK4259617T3 (enExample)
DO (1) DOP2023000115A (enExample)
EC (1) ECSP23040828A (enExample)
ES (1) ES2997117T3 (enExample)
FI (1) FI4259617T3 (enExample)
GE (2) GEAP202316287A (enExample)
HR (1) HRP20241543T1 (enExample)
HU (1) HUE069255T2 (enExample)
IL (1) IL303296A (enExample)
JO (1) JOP20230132A1 (enExample)
LT (1) LT4259617T (enExample)
MX (1) MX2023006903A (enExample)
PE (1) PE20231501A1 (enExample)
PL (1) PL4259617T3 (enExample)
PT (1) PT4259617T (enExample)
RS (1) RS66294B1 (enExample)
SA (1) SA523441083B1 (enExample)
SI (1) SI4259617T1 (enExample)
TW (1) TW202237589A (enExample)
WO (1) WO2022122914A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4011873A1 (en) * 2020-12-10 2022-06-15 Bayer Aktiengesellschaft Substituted pyrazolo piperidine carboxylic acids
EP4011874A1 (en) * 2020-12-10 2022-06-15 Bayer Aktiengesellschaft Substituted pyrazolo piperidine carboxylic acids
EP4536205A1 (en) 2022-06-09 2025-04-16 Bayer Aktiengesellschaft Soluble guanylate cyclase activators for use in the treatment of heart failure with preserved ejection fraction in women
WO2024163561A1 (en) * 2023-01-31 2024-08-08 Invivosciences, Inc. Systems and methods for treating heart failure with preserved ejection fraction
WO2025067414A1 (zh) * 2023-09-27 2025-04-03 海思科医药集团股份有限公司 吡唑羧酸衍生物及其在医药上的应用
WO2025162280A1 (zh) * 2024-01-30 2025-08-07 海思科医药集团股份有限公司 吡唑羧酸衍生物及其在医药上的应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
DE19943636A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943634A1 (de) 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10110750A1 (de) 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE10110749A1 (de) 2001-03-07 2002-09-12 Bayer Ag Substituierte Aminodicarbonsäurederivate
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
BRPI0816382A2 (pt) * 2007-09-06 2015-02-24 Merck Sharp & Dohme Composto, composição, e, métodos para ativar a guanilato ciclase solúvel e para tratar ou previnir doenças
DE102010001064A1 (de) 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
UA109650C2 (xx) 2010-02-27 2015-09-25 Біс-арилзв'язані арилтриазолони та їх застосування
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
EA201390060A1 (ru) 2010-07-09 2013-07-30 Байер Интеллектуэль Проперти Гмбх Аннелированные пиримидины и триазины и их применение для лечения и/или профилактики сердечно-сосудистых заболеваний
DE102010040233A1 (de) 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Bicyclische Aza-Heterocyclen und ihre Verwendung
EP2632551B1 (en) * 2010-10-28 2016-07-06 Merck Sharp & Dohme Corp. Soluble guanylate cyclase activators
DE102010043379A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung
DE102011007272A1 (de) 2011-04-13 2012-10-18 Bayer Pharma Aktiengesellschaft Verzweigte 3-Phenylpropionsäure-Derivate und ihre Verwendung
HRP20191755T1 (hr) * 2012-09-07 2019-12-27 Boehringer Ingelheim International Gmbh Alkoksipirazoli kao aktivatori topljive gvanilat ciklaze
WO2015095515A1 (en) * 2013-12-20 2015-06-25 Novartis Ag Sgc activators for the treatment of glaucoma
SI3215498T1 (sl) 2014-11-03 2018-11-30 Bayer Pharma Aktiengesellschaft Hidroksialkil-substituirani derivati feniltriazola in njihove uporabe
GB201705263D0 (en) * 2017-03-31 2017-05-17 Probiodrug Ag Novel inhibitors
CN116829545A (zh) * 2020-12-10 2023-09-29 拜耳公司 取代的吡唑基哌啶羧酸
AU2021398486A1 (en) * 2020-12-10 2023-06-22 Bayer Aktiengesellschaft The use of sgc activators for the treatment of ophthalmologic diseases

Also Published As

Publication number Publication date
DOP2023000115A (es) 2023-07-16
AU2021393988A1 (en) 2023-06-22
DK4259617T3 (da) 2024-12-09
CL2023001632A1 (es) 2023-11-10
LT4259617T (lt) 2024-12-10
PE20231501A1 (es) 2023-09-26
CA3204495A1 (en) 2022-06-16
GEAP202316287A (en) 2023-09-11
AU2021393988A9 (en) 2024-09-19
CN116710439A (zh) 2023-09-05
JP2023552583A (ja) 2023-12-18
PL4259617T3 (pl) 2025-03-17
GEP20247649B (en) 2024-07-25
SI4259617T1 (sl) 2025-02-28
AR124297A1 (es) 2023-03-15
HUE069255T2 (hu) 2025-02-28
EP4259617B1 (en) 2024-10-23
PT4259617T (pt) 2024-12-05
EP4259617A1 (en) 2023-10-18
ECSP23040828A (es) 2023-07-31
IL303296A (en) 2023-07-01
KR20230118144A (ko) 2023-08-10
SA523441083B1 (ar) 2025-06-12
US20240051935A1 (en) 2024-02-15
RS66294B1 (sr) 2025-01-31
HRP20241543T1 (hr) 2025-01-03
WO2022122914A1 (en) 2022-06-16
FI4259617T3 (fi) 2024-11-27
MX2023006903A (es) 2023-06-26
ES2997117T3 (en) 2025-02-14
CR20230242A (es) 2023-07-19
CO2023007335A2 (es) 2023-06-09
JOP20230132A1 (ar) 2023-06-08

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