TW202214609A - 抗血小板藥物及其用途 - Google Patents

抗血小板藥物及其用途 Download PDF

Info

Publication number
TW202214609A
TW202214609A TW110127818A TW110127818A TW202214609A TW 202214609 A TW202214609 A TW 202214609A TW 110127818 A TW110127818 A TW 110127818A TW 110127818 A TW110127818 A TW 110127818A TW 202214609 A TW202214609 A TW 202214609A
Authority
TW
Taiwan
Prior art keywords
alkyl
pharmaceutically acceptable
compound
acceptable salt
heteroalkyl
Prior art date
Application number
TW110127818A
Other languages
English (en)
Chinese (zh)
Inventor
自強 顧
袁超 張
何公欣
侯凱
吳豪
Original Assignee
大陸商上海柯君醫藥科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 大陸商上海柯君醫藥科技有限公司 filed Critical 大陸商上海柯君醫藥科技有限公司
Publication of TW202214609A publication Critical patent/TW202214609A/zh

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
TW110127818A 2020-07-29 2021-07-29 抗血小板藥物及其用途 TW202214609A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2020105513 2020-07-29
WOPCT/CN2020/105513 2020-07-29

Publications (1)

Publication Number Publication Date
TW202214609A true TW202214609A (zh) 2022-04-16

Family

ID=80037185

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110127818A TW202214609A (zh) 2020-07-29 2021-07-29 抗血小板藥物及其用途

Country Status (14)

Country Link
US (2) US12410132B2 (https=)
EP (2) EP4188935A4 (https=)
JP (1) JP2023535815A (https=)
KR (2) KR102906376B1 (https=)
CN (4) CN119033782B (https=)
AR (1) AR123078A1 (https=)
AU (1) AU2021317436A1 (https=)
BR (1) BR112023001595A2 (https=)
CA (1) CA3186645A1 (https=)
ES (1) ES3046366T3 (https=)
IL (1) IL299979A (https=)
MX (1) MX2023001232A (https=)
TW (1) TW202214609A (https=)
WO (1) WO2022022559A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202339745A (zh) * 2022-01-28 2023-10-16 大陸商上海柯君醫藥科技有限公司 抗血小板藥物的藥物組合物及其用途
CN116813532A (zh) * 2023-06-29 2023-09-29 上海柯君医药科技有限公司 一种哌啶化合物的制备方法
WO2025108307A1 (zh) * 2023-11-24 2025-05-30 上海柯君医药科技有限公司 一种含哌啶环化合物的苯磺酸盐、其制备方法及应用
WO2025108300A1 (zh) * 2023-11-24 2025-05-30 上海柯君医药科技有限公司 一种含哌啶环化合物的苯磺酸盐的晶型、其制备方法及应用
CN119019320B (zh) * 2024-10-29 2025-03-11 上海柯君医药科技有限公司 一种具有抗血小板活性的哌啶类化合物的制备方法
CN119176829B (zh) * 2024-11-26 2025-04-15 上海柯君医药科技有限公司 一种哌啶环化合物的制备方法
CN119192061B (zh) * 2024-11-28 2025-05-13 上海柯君医药科技有限公司 一种含哌啶环的化合物的纯化方法
CN119371453A (zh) * 2024-12-30 2025-01-28 上海柯君医药科技有限公司 一种抗血小板药物中间体的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ334389A (en) 1996-08-28 2001-05-25 Ube Industries Cyclic amine derivatives
US20060019929A1 (en) * 2004-07-07 2006-01-26 Albert Friesen Combination therapies employing platelet aggregation drugs
CN104379589A (zh) * 2012-05-07 2015-02-25 塞利克斯比奥私人有限公司 抗血小板药剂的前药
KR20150038369A (ko) * 2012-08-03 2015-04-08 브리스톨-마이어스 스큅 컴퍼니 인자 XIa 억제제로서의 디히드로피리돈 P1
CN103626694A (zh) * 2012-08-29 2014-03-12 中国药科大学 不饱和环胺衍生物、其制备方法及其医药用途
NO2721243T3 (https=) * 2014-10-01 2018-10-20
CN106554303A (zh) * 2015-09-25 2017-04-05 陕西合成药业股份有限公司 噻吩并吡啶类衍生物及其制备方法和用途
CN106554368A (zh) * 2015-09-25 2017-04-05 陕西合成药业股份有限公司 噻吩并吡啶类衍生物及其制备方法和用途
CN119019320B (zh) * 2024-10-29 2025-03-11 上海柯君医药科技有限公司 一种具有抗血小板活性的哌啶类化合物的制备方法
CN119192061B (zh) * 2024-11-28 2025-05-13 上海柯君医药科技有限公司 一种含哌啶环的化合物的纯化方法

Also Published As

Publication number Publication date
EP4188935A4 (en) 2024-07-17
EP4342532B1 (en) 2025-09-03
KR20230047425A (ko) 2023-04-07
US20240279178A1 (en) 2024-08-22
MX2023001232A (es) 2023-05-15
EP4342532A2 (en) 2024-03-27
CN116194459A (zh) 2023-05-30
EP4342532C0 (en) 2025-09-03
AU2021317436A1 (en) 2023-02-23
CA3186645A1 (en) 2022-02-03
IL299979A (en) 2023-03-01
US12410132B2 (en) 2025-09-09
KR102906376B1 (ko) 2025-12-30
WO2022022559A1 (en) 2022-02-03
ES3046366T3 (en) 2025-12-01
CN117343000A (zh) 2024-01-05
EP4342532A3 (en) 2024-07-17
KR20250073569A (ko) 2025-05-27
JP2023535815A (ja) 2023-08-21
US20250333382A1 (en) 2025-10-30
CN119552111B (zh) 2026-01-02
CN119033782A (zh) 2024-11-29
CN119552111A (zh) 2025-03-04
BR112023001595A2 (pt) 2023-04-04
EP4188935A1 (en) 2023-06-07
CN119033782B (zh) 2025-04-25
AR123078A1 (es) 2022-10-26

Similar Documents

Publication Publication Date Title
TW202214609A (zh) 抗血小板藥物及其用途
AU2022271425B2 (en) Processes of making and crystalline forms of a MDM2 inhibitor
RU2476430C2 (ru) Производные аминодигидротиазина, замещенные циклической группой
JPH08507049A (ja) 低脂血症性化合物１，４−チアゼピン
EP4470539A1 (en) Pharmaceutical composition of antiplatelet drug, and use thereof
KR102797099B1 (ko) 2-[(3r)-3-메틸모르폴린-4-일]-4-(1-메틸-1h-피라졸-5-일)-8-(1h-피라졸-5-일)-1,7-나프티리딘의 제조 방법
JP2008519046A (ja) キノリン化合物およびそれから得られる生成物の調製方法
RU2841656C1 (ru) Антитромбоцитарные лекарственные средства и их применение
US11834413B2 (en) Antiplatelet drugs and uses thereof
HK40117914A (zh) 抗血小板药物和其用途
HK40117914B (zh) 抗血小板药物和其用途
HK40090099A (zh) 抗血小板药物和其用途
US4908361A (en) Tetrahydroisoquino(2,1-C)(1,3)benzodiazepines
WO2023138621A1 (en) Atr inhibitors and uses thereof
JP2023544037A (ja) ビヘテロアリール化合物およびその結晶形態を調製するための方法
HK40032239B (en) Receptor inhibitors, pharmaceutical compositions comprising the same and use thereof