TW202210081A - 非酒精性脂肪肝炎(nash)之治療 - Google Patents

非酒精性脂肪肝炎(nash)之治療 Download PDF

Info

Publication number
TW202210081A
TW202210081A TW110118457A TW110118457A TW202210081A TW 202210081 A TW202210081 A TW 202210081A TW 110118457 A TW110118457 A TW 110118457A TW 110118457 A TW110118457 A TW 110118457A TW 202210081 A TW202210081 A TW 202210081A
Authority
TW
Taiwan
Prior art keywords
25hc3s
salt
day
nash
treatment
Prior art date
Application number
TW110118457A
Other languages
English (en)
Chinese (zh)
Inventor
偉琦 林
詹姆士 布朗
泰倫斯 布萊斯克
Original Assignee
美商杜瑞克公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 美商杜瑞克公司 filed Critical 美商杜瑞克公司
Publication of TW202210081A publication Critical patent/TW202210081A/zh

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/232Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
TW110118457A 2020-05-22 2021-05-21 非酒精性脂肪肝炎(nash)之治療 TW202210081A (zh)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US202063029361P 2020-05-22 2020-05-22
US63/029,361 2020-05-22
US202063030207P 2020-05-26 2020-05-26
US63/030,207 2020-05-26
US202063113116P 2020-11-12 2020-11-12
US63/113,116 2020-11-12
US202163146555P 2021-02-05 2021-02-05
US63/146,555 2021-02-05

Publications (1)

Publication Number Publication Date
TW202210081A true TW202210081A (zh) 2022-03-16

Family

ID=78707644

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110118457A TW202210081A (zh) 2020-05-22 2021-05-21 非酒精性脂肪肝炎(nash)之治療

Country Status (11)

Country Link
US (1) US20230181601A1 (enExample)
EP (1) EP4153164A4 (enExample)
JP (1) JP2023527153A (enExample)
KR (1) KR20230015939A (enExample)
CN (1) CN115916181A (enExample)
AU (1) AU2021273936A1 (enExample)
BR (1) BR112022022737A2 (enExample)
CA (1) CA3195103A1 (enExample)
MX (1) MX2022014575A (enExample)
TW (1) TW202210081A (enExample)
WO (1) WO2021237143A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018026781A1 (en) 2016-08-02 2018-02-08 Virginia Commonwealth University Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI20848A (sl) * 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
WO2006047022A1 (en) * 2004-10-25 2006-05-04 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of cholesterol homeostasis, for therapy of hypercholesterolemia, hyperlipidemia, and atherosclerosis
US8399441B2 (en) * 2004-10-25 2013-03-19 Virginia Commonwealth University Nuclear sulfated oxysterol, potent regulator of lipid homeostasis, for therapy of hypercholesterolemia, hypertriglycerides, fatty liver diseases, and atherosclerosis
US9034859B2 (en) * 2011-04-06 2015-05-19 Virginia Commonwealth University Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation
JP6185473B2 (ja) * 2011-09-16 2017-08-23 ガレクティン・セラピューティクス・インコーポレイテッドGalectin Therapeutics, Inc. 非アルコール性脂肪性肝炎および非アルコール性脂肪肝疾患を処置するためのガラクト−ラムノガラクツロネート組成物
CN105592846A (zh) * 2013-03-15 2016-05-18 持田制药株式会社 用于治疗非酒精性脂肪性肝炎的组合物和方法
WO2018026781A1 (en) * 2016-08-02 2018-02-08 Virginia Commonwealth University Compositions comprising 5-cholesten-3, 25-diol, 3-sulfate (25hc3s) or pharmaceutically acceptable salt thereof and at least one cyclic oligosaccharide
KR102462275B1 (ko) * 2016-08-02 2022-11-01 듀렉트 코퍼레이션 산소화 콜레스테롤 술페이트, 및 폴리알킬렌 글리콜, 카르복시메틸 셀룰로오스 및 폴리옥실글리세리드 중 적어도 하나를 포함하는 조성물
MX2019012535A (es) * 2017-04-18 2020-08-17 Genfit Combinacion que comprende un agonista de ppar tal como elafibranor y un inhibidor de la acetil-coa carboxilasa (acc).
JP7479278B2 (ja) * 2017-10-06 2024-05-08 ギリアード サイエンシーズ, インコーポレイテッド Acc阻害剤を含む併用療法

Also Published As

Publication number Publication date
EP4153164A1 (en) 2023-03-29
WO2021237143A1 (en) 2021-11-25
BR112022022737A2 (pt) 2023-01-31
MX2022014575A (es) 2022-12-15
US20230181601A1 (en) 2023-06-15
CN115916181A (zh) 2023-04-04
EP4153164A4 (en) 2024-06-26
JP2023527153A (ja) 2023-06-27
CA3195103A1 (en) 2021-11-25
KR20230015939A (ko) 2023-01-31
AU2021273936A1 (en) 2022-12-08

Similar Documents

Publication Publication Date Title
Gawrieh et al. Saroglitazar, a PPAR‐α/γ agonist, for treatment of NAFLD: a randomized controlled double‐blind phase 2 trial
EP3054940B1 (en) Compositions and methods for treating non-alcoholic steatohepatitis
JP2021063088A (ja) 非アルコール性脂肪肝疾患および/またはリポジストロフィーの処置のための方法
JP7022136B2 (ja) 非アルコール性脂肪性肝炎の治療のための方法及び医薬組成物
CN114555044B (zh) 酒精性肝炎的治疗
TW202210081A (zh) 非酒精性脂肪肝炎(nash)之治療
TW202210082A (zh) 非酒精性脂肪肝炎(nash)之治療
WO2019108551A1 (en) Methods and pharmaceutical compositions for the treatment of non-alcoholic steatohepatitis
TW202214256A (zh) 非酒精性脂肪肝炎(nash)之治療
HK40089967A (zh) 非酒精性脂肪性肝炎(nash)的治疗
HK40089720A (zh) 非酒精性脂肪性肝炎(nash)的治疗
Tun et al. Amiodarone-induced liver attenuation on CT scan: alarming signal for toxicity and prompt discontinuation
BR122025021620A2 (pt) Composição compreendendo 25hc3s ou seu sal no tratamento de hepatite alcoólica
Manevska et al. SUBACUTE THYROIDITIS AND ITS CLINICAL CHARACTERISTICS-A RETROSPECTIVE SINGLE CENTER CLINICAL STUDY
WO2023210716A1 (ja) Cbp/カテニン阻害剤の肝線維症治療レジメン
Carvalho Cushing Syndrome due to black adrenal adenoma: difficulties in the differential diagnosis of a patient with an adrenal adenoma
WO2020205026A1 (en) Compositions and methods to treat non-alcoholic fatty liver diseases (nafld)
Franzè et al. P. 05.11 HIGH EXPRESSION OF THE “A DISINTEGRIN AND METALLOPROTEASE” 19 (ADAM19), A SHEDDASE FOR TNF-α IN THE MUCOSA OF PATIENTS WITH INFLAMMATORY BOWEL DISEASES
Maurya et al. Extrapulmonary Tuberculosis-Its Management and Control