TW202142230A - 用於以抗ｔｉｇｉｔ拮抗體抗體治療癌症之方法 - Google Patents

用於以抗ｔｉｇｉｔ拮抗體抗體治療癌症之方法 Download PDF

Info

Publication number
TW202142230A
TW202142230A TW110102913A TW110102913A TW202142230A TW 202142230 A TW202142230 A TW 202142230A TW 110102913 A TW110102913 A TW 110102913A TW 110102913 A TW110102913 A TW 110102913A TW 202142230 A TW202142230 A TW 202142230A
Authority
TW
Taiwan
Prior art keywords
subject
dose
weeks
cancer
antibody
Prior art date
Application number
TW110102913A
Other languages
English (en)
Chinese (zh)
Inventor
凱瑟琳 賴
劉玉儀
安東尼 鐘哈 李
石 李
伊凡 蓋爾 林劉
克莉絲汀娜 吉恩 馬瑟尼
黛安娜 門杜斯
雷蒙 Ｄ 蒙
德 安 阮
吉爾帕 布潘達 派托爾
清廣 范
伊莎貝爾 安 魯尼
海瑟 布萊斯 史蒂文斯
莎拉 瑪麗 脫特曼
麗佳 王
宇雷 王
派翠克 喬治 羅伯特 威廉斯
本傑明 吳
顏宜彬
張愛晶
張曉松
馬克斯 戴爾 貝林格
希拉 巴瑞克
伊莉莎白 亞歷山卓 班尼特
馬賽拉 盧西亞 卡斯楚
艾德華 南塞克 查
陳慧敏
崔仁智
克里斯多夫 羅蘭 寇特
威拉 維內 德岡卡爾
芭芭拉 珍妮佛 吉里茲
黃田
金柏莉 馬尤米 科馬蘇巴拉
Original Assignee
美商建南德克公司
瑞士商赫孚孟拉羅股份公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2020/024526 external-priority patent/WO2021194481A1/fr
Priority claimed from PCT/US2020/049415 external-priority patent/WO2022050954A1/fr
Application filed by 美商建南德克公司, 瑞士商赫孚孟拉羅股份公司 filed Critical 美商建南德克公司
Publication of TW202142230A publication Critical patent/TW202142230A/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
TW110102913A 2020-01-27 2021-01-26 用於以抗ｔｉｇｉｔ拮抗體抗體治療癌症之方法 TW202142230A (zh)

Applications Claiming Priority (28)

Application Number Priority Date Filing Date Title
US202062966448P 2020-01-27 2020-01-27
US62/966,448 2020-01-27
US202062985822P 2020-03-05 2020-03-05
US62/985,822 2020-03-05
US202062994272P 2020-03-24 2020-03-24
US62/994,272 2020-03-24
WOPCT/US20/24526 2020-03-24
PCT/US2020/024526 WO2021194481A1 (fr) 2020-03-24 2020-03-24 Dosage pour le traitement avec des anticorps antagonistes anti-tigit et anti-pd-l1
US202063059054P 2020-07-30 2020-07-30
US63/059,054 2020-07-30
US202063059960P 2020-07-31 2020-07-31
US63/059,960 2020-07-31
US202063074827P 2020-09-04 2020-09-04
US202063074807P 2020-09-04 2020-09-04
PCT/US2020/049415 WO2022050954A1 (fr) 2020-09-04 2020-09-04 Dosage pour traitement avec anticorps antagonistes anti-tigit et anti-pd-l1
US63/074,807 2020-09-04
US63/074,827 2020-09-04
WOPCT/US20/49415 2020-09-04
US202063085890P 2020-09-30 2020-09-30
US63/085,890 2020-09-30
US202063105198P 2020-10-23 2020-10-23
US63/105,198 2020-10-23
US202063114517P 2020-11-16 2020-11-16
US63/114,517 2020-11-16
US202063124693P 2020-12-11 2020-12-11
US63/124,693 2020-12-11
US202063127109P 2020-12-17 2020-12-17
US63/127,109 2020-12-17

Publications (1)

Publication Number Publication Date
TW202142230A true TW202142230A (zh) 2021-11-16

Family

ID=74626264

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110102913A TW202142230A (zh) 2020-01-27 2021-01-26 用於以抗ｔｉｇｉｔ拮抗體抗體治療癌症之方法

Country Status (10)

Country Link
EP (1) EP4096646A1 (fr)
JP (1) JP2023511595A (fr)
KR (1) KR20220133243A (fr)
CN (1) CN115315256A (fr)
AU (1) AU2021212662A1 (fr)
CA (1) CA3165187A1 (fr)
IL (1) IL294800A (fr)
MX (1) MX2022009170A (fr)
TW (1) TW202142230A (fr)
WO (1) WO2021154761A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021257503A1 (fr) * 2020-06-16 2021-12-23 Genentech, Inc. Méthodes et compositions de traitement du cancer du sein triple négatif
WO2023279092A2 (fr) * 2021-07-02 2023-01-05 Genentech, Inc. Méthodes et compositions pour le traitement du cancer
WO2023010094A2 (fr) * 2021-07-28 2023-02-02 Genentech, Inc. Méthodes et compositions pour le traitement du cancer
KR20240047393A (ko) * 2021-08-10 2024-04-12 머크 샤프 앤드 돔 엘엘씨 Tigit 길항제, pd-1 길항제 및 화학요법제(들)를 포함하는 치료 조합물
WO2023018675A1 (fr) * 2021-08-10 2023-02-16 Merck Sharp & Dohme Llc Méthodes de traitement du cancer, d'une maladie infectieuse ou d'une infection à l'aide d'une combinaison d'un antagoniste de tigit, d'un antagoniste de pd -1 et de lenvatinib ou d'un sel pharmaceutiquement acceptable de celui-ci
CN118103067A (zh) * 2021-09-14 2024-05-28 信达生物制药(苏州)有限公司 抗pd-1抗体和化疗药的药物组合及其使用方法
CN117940453A (zh) * 2021-09-15 2024-04-26 江苏恒瑞医药股份有限公司 特异性结合pd-1的蛋白及其医药用途
WO2023122665A1 (fr) * 2021-12-22 2023-06-29 Genentech, Inc. Formulations cliniques d'anticorps anti-tigit
CN114181310B (zh) * 2022-02-14 2022-07-05 中山康方生物医药有限公司 抗tigit抗体、其药物组合物及用途

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
ES2241710T3 (es) 1991-11-25 2005-11-01 Enzon, Inc. Procedimiento para producir proteinas multivalentes de union a antigeno.
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
GB9314893D0 (en) 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
US5654307A (en) 1994-01-25 1997-08-05 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
EP0772609B1 (fr) 1994-07-21 1999-02-24 Akzo Nobel N.V. Formulations de peroxides cetoniques cycliques
US5804396A (en) 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
DE69536015D1 (de) 1995-03-30 2009-12-10 Pfizer Prod Inc Chinazolinone Derivate
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
GB9508565D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
BR9609617B1 (pt) 1995-07-06 2010-07-27 derivados de 7h-pirrol[2,3-d]pirimidina, e composição farmacêutica.
US5760041A (en) 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
CA2249446C (fr) 1996-04-12 2008-06-17 Warner-Lambert Company Inhibiteurs irreversibles de tyrosine kinases
AU3766897A (en) 1996-07-13 1998-02-09 Glaxo Group Limited Fused heterocyclic compounds as protein tyrosine kinase inhibitors
ID18494A (id) 1996-10-02 1998-04-16 Novartis Ag Turunan pirazola leburan dan proses pembuatannya
UA73073C2 (uk) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
US6002008A (en) 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
JP4327259B2 (ja) 1997-05-06 2009-09-09 ワイス・ホールディングズ・コーポレイション 多発性嚢胞腎の治療のためのキナゾリン化合物の使用
ZA986732B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
ZA986729B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitors of tyrosine kinases
TW436485B (en) 1997-08-01 2001-05-28 American Cyanamid Co Substituted quinazoline derivatives
NZ503991A (en) 1997-11-06 2001-11-30 American Cyanamid Co Use of quinazoline derivatives as tyrosine kinase inhibitors for treating colonic polyps
PT1034298E (pt) 1997-12-05 2012-02-03 Scripps Research Inst Humanização de anticorpo murino
NZ512189A (en) 1998-11-19 2003-10-31 Warner Lambert Co N-[4-(3-chloro-4-fluoro-phenylamino)-7-(3-morpholin-4- yl-propoxy)-quinazolin-6-yl]-acrylamide useful as an irreversible inhibitor of tyrosine kinases
AU2005250484B2 (en) 2004-06-04 2011-08-11 Genentech, Inc. EGFR mutations
AU2013318618B2 (en) 2012-09-24 2017-04-06 Ventana Medical Systems, Inc. Method of identifying treatment responsive non-small cell lung cancer using anaplastic lymphoma kinase (ALK) as a marker
PT3294770T (pt) 2015-05-12 2020-12-04 Hoffmann La Roche Métodos terapêuticos e diagnósticos para o cancro
IL255372B (en) 2015-05-29 2022-07-01 Genentech Inc Therapeutic and diagnostic methods for cancer
CA3092108A1 (fr) * 2018-02-26 2019-08-29 Genentech, Inc. Dosage pour traitement avec des anticorps antagonistes anti-tigit et anti-pd-l1

Also Published As

Publication number Publication date
AU2021212662A1 (en) 2022-08-11
JP2023511595A (ja) 2023-03-20
KR20220133243A (ko) 2022-10-04
CN115315256A (zh) 2022-11-08
WO2021154761A1 (fr) 2021-08-05
MX2022009170A (es) 2022-08-17
CA3165187A1 (fr) 2021-08-05
EP4096646A1 (fr) 2022-12-07
IL294800A (en) 2022-09-01

Similar Documents

Publication Publication Date Title
US20180346586A1 (en) Methods of treating cancer using anti-ox40 antibodies
TW202142230A (zh) 用於以抗ｔｉｇｉｔ拮抗體抗體治療癌症之方法
US20180256711A1 (en) Methods of treating cancer using anti-ox40 antibodies and pd-1 axis binding antagonists
CA3038712A1 (fr) Methodes therapeutiques et de diagnostic du cancer
US20220016243A1 (en) Methods for treatment of cancer with an anti-tigit antagonist antibody
CN115916348A (zh) 使用抗tigit抗体和pd-1轴结合拮抗剂的治疗
TW202126690A (zh) 用抗ｔｉｇｉｔ和抗ｐｄ－ｌ１拮抗劑抗體給藥治療
US20200171146A1 (en) Methods of treating lung cancer with a pd-1 axis binding antagonist, an antimetabolite, and a platinum agent
TW202015730A (zh) 以pd-1 軸結合拮抗劑、鉑劑及拓撲異構酶ii 抑制劑治療肺癌之方法
TWI836278B (zh) 用抗fcrh5/抗cd3雙特異性抗體進行治療之給藥
WO2021222167A1 (fr) Procédés et compositions pour l'immunothérapie du cancer du poumon non à petites cellules
TW202320848A (zh) 治療癌症之方法及組成物
WO2021194481A1 (fr) Dosage pour le traitement avec des anticorps antagonistes anti-tigit et anti-pd-l1