TW202117017A - 人類心肌病的ａａｖ心臟基因療法 - Google Patents
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| CN116867512A (zh) * | 2020-12-23 | 2023-10-10 | 佛罗里达州大学研究基金会 | 包装效率提高的用于心脏基因治疗的载体 |
| CN119317718A (zh) | 2022-01-25 | 2025-01-14 | 宾夕法尼亚州大学信托人 | 用于改善心脏转导和肝脏去靶向的aav衣壳 |
| EP4634394A2 (en) | 2022-12-17 | 2025-10-22 | The Trustees of The University of Pennsylvania | Recombinant aav mutant vectors with cardiac and skeletal muscle-specific targeting motifs and compositions containing same |
| WO2024130070A2 (en) | 2022-12-17 | 2024-06-20 | The Trustees Of The University Of Pennsylvania | Recombinant aav capsids with cardiac- and skeletal muscle- specific targeting motifs and uses thereof |
| WO2025007046A1 (en) | 2023-06-29 | 2025-01-02 | The Trustees Of The University Of Pennsylvania | Mutant aav with central nervous system targeting motifs and compositions containing same |
| KR20260114566A (ko) | 2023-11-14 | 2026-07-22 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 심근 및 골격근-특이적 표적화 모티프를 갖는 조성물 및 이의 용도 |
| WO2026132516A1 (en) * | 2024-12-20 | 2026-06-25 | Patrick Most | S100a1 protein-derived peptide for use in treating cancer or in treating or preventing antineoplastic agent-mediated cytotoxicity, cancer therapy-related cardiac dysfunction or cancer therapy related heart failure |
| CN121674484A (zh) * | 2025-11-14 | 2026-03-17 | 广州派真生物技术有限公司 | 一种高产细胞毒性基因的rAAV质粒系统及应用 |
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| WO2008054713A2 (en) * | 2006-10-30 | 2008-05-08 | Thomas Jefferson University | Tissue specific gene therapy treatment |
| EP2295072A1 (en) * | 2009-09-15 | 2011-03-16 | Max-Delbrück-Centrum für Molekulare Medizin (MDC) | Use of ARC for inhibiting cell death during liver failure |
| EP3052118A1 (en) * | 2013-10-01 | 2016-08-10 | Ruprecht-Karls-Universität Heidelberg | S100 based treatment of cardiac power failure |
| WO2017191274A2 (en) * | 2016-05-04 | 2017-11-09 | Curevac Ag | Rna encoding a therapeutic protein |
| US20200308582A1 (en) * | 2017-10-12 | 2020-10-01 | Universität Heidelberg | Kcnk3-based gene therapy of cardiac arrhythmia |
| CN112272705A (zh) * | 2018-06-08 | 2021-01-26 | 佛罗里达大学研究基金会有限公司 | 用于心肌病的aav心脏基因治疗 |
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| CA3142534A1 (en) | 2021-01-28 |
| CO2022001686A2 (es) | 2022-03-29 |
| EP3999074A4 (en) | 2023-08-16 |
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