TW202042783A - External preparation for skin and method for improving ultraviolet protection effect - Google Patents

Abstract

To provide an external preparation for skin having improved ultraviolet protection effect. Also, to provide a method for improving ultraviolet protection effect. An external preparation for skin that comprises an ultraviolet scattering agent and/or an ultraviolet absorbent and farnesol. An external preparation for skin that comprises farnesol as an active ingredient for improving ultraviolet protection effect. A method for improving ultraviolet protection effect in which farnesol is used.

Description

Skin topical agent and method of enhancing UV protection effect

The present invention relates to an external preparation for the skin and a method for improving the UV protection effect.

The purpose of sunscreen cosmetics is to cut off the ultraviolet rays in the sun and protect the skin from the harmful effects of ultraviolet rays. Examples of the base agent include emulsification type, emulsion type, oil type, etc., but no matter what the base agent is, it is to block ultraviolet rays. High SPF (Sun Protection Factor) values can be obtained by irradiating the skin, and they are equipped with UV absorbers or UV scattering agents in high profile. Generally, for high-preparation of UV absorbers or UV-scattering agents, high-preparation of oil is necessary. However, if the pre-prepared oils are high, there is a problem that stickiness cannot be suppressed. Especially for oil-in-water emulsified cosmetics that require moisturization or good ductility for use, it is difficult to achieve a high SPF value.

In order to solve this problem, the applicant proposed in Patent Document 1 an oil-in-water emulsified cosmetic, which can maintain a certain amount of sucrose fatty acid esters by mixing the total amount of the oil phase below a certain level. It has the moisturizing properties or good extensibility required for the oil-in-water emulsified cosmetics, and inhibits stickiness, so as to achieve a higher SPF value.

Moreover, the applicant based on farnesol only inhibits the growth of harmful bacteria Staphylococcus aureus, and does not affect the growth of harmless bacteria Staphylococcus epidermidis. Moreover, xylitol only becomes a nutrient source for harmless Staphylococcus epidermidis. The knowledge that Staphylococcus aureus, which is a harmful bacteria, is a nutrient source has proposed a selective antibacterial composition prepared with farnesol and xylitol (Patent Document 2). Furthermore, a skin external preparation combining farnesol and tocopherol that can last a long period of time has been proposed (Patent Document 3). [Prior Technical Literature] [Patent Literature]

[Patent Document 1] Japanese Patent No. 6321105 [Patent Document 2] Japanese Patent No. 4011787 [Patent Document 3] Japanese Patent Laid-Open No. 2002-293735

[The problem to be solved by the invention]

As shown in Patent Document 2 or 3, farnesol can be selectively sterilized, and it may be formulated in cosmetics to have a floral-like fragrance. However, the relationship with the ultraviolet absorber or the ultraviolet scattering agent has not been studied so far. The inventors have conducted diligent studies, and as a result, surprisingly learned that farnesol has the effect of enhancing the ultraviolet protection effect, and completed the present invention.

That is, the present invention was completed based on the above-mentioned knowledge, and its object is to provide an external preparation for skin with improved ultraviolet protection effect and a method for improving ultraviolet protection effect. [Technical means to solve the problem]

The external preparation for skin of the present invention contains an ultraviolet scattering agent and/or an ultraviolet absorber, and farnesol.

Preferably, the ultraviolet scattering agent is a hydrophobic treatment scattering agent.

Preferably, the ultraviolet absorber is selected from the group consisting of ethylhexyl triacetate, 4-tert-butyl-4'-methoxydiphenylmethyl methane, diethylamino hydroxybenzyl hexyl benzoate and diethyl At least one of hexyloxy phenol methoxy phenyl tri 𠯤.

The content of farnesol is preferably 0.1-10% by mass relative to the total amount of the external preparation for skin.

Preferably, the content of farnesol is 0.5% by mass or more with respect to the total amount of the ultraviolet scattering agent and/or ultraviolet absorber.

The external preparation for skin may further contain polar oil. In this case, it is preferable that the content of farnesol is 2% by mass or more with respect to the total amount of polar oil.

In another aspect, the external preparation for skin of the present invention uses farnesol as an effective ingredient for enhancing the UV protection effect.

The content of farnesol is preferably 0.1-10% by mass relative to the total amount of the external preparation for skin.

Preferably, the ultraviolet protection effect is produced by an ultraviolet scattering agent and/or an ultraviolet absorber.

Preferably, the ultraviolet scattering agent is a hydrophobic treatment scattering agent.

Preferably, the ultraviolet absorber is selected from the group consisting of ethylhexyl triacetate, 4-tert-butyl-4'-methoxydiphenylmethyl methane, diethylamino hydroxybenzyl hexyl benzoate and diethyl At least one of hexyloxy phenol methoxy phenyl tri 𠯤.

Preferably, the content of farnesol is 0.5% by mass or more with respect to the total amount of the ultraviolet scattering agent and/or ultraviolet absorber.

The external preparation for skin may further contain polar oil. In this case, it is preferable that the content of farnesol is 2% by mass or more with respect to the total amount of polar oil.

The method for improving the ultraviolet protection effect of the present invention uses farnesol. [Effects of Invention]

The skin external preparation of the present invention contains ultraviolet scattering agent and/or ultraviolet absorber, and farnesol, or uses farnesol as an effective ingredient for enhancing the effect of ultraviolet protection, and therefore contains the same amount of ultraviolet scattering agent And/or the skin external preparation of ultraviolet absorber can improve the effect of ultraviolet protection.

The present invention will be explained in detail below. The external preparation for skin of the present invention contains an ultraviolet scattering agent and/or an ultraviolet absorber, and farnesol. In another aspect, the external preparation for skin of the present invention uses farnesol as an effective ingredient for enhancing the effect of UV protection. Each component will be explained in detail.

[Farnesol] Farnesol (3,7,11-trimethyl-2,6,10-dodecatrien-1-ol) is commercially available as a synthetic fragrance with antibacterial properties, with a fresh green leafy and floral fragrance , There are cases of blending in cosmetics. Commercially available farnesol is directly synthesized from geraniol. For example, farnesol manufactured by Kuraray and DORAGOCO is commercially available.

In the external preparation for skin of the present invention, farnesol is preferably in the range of 0.1 to 10% by mass, more preferably in the range of 0.1 to 5% by mass relative to the total amount of the external preparation for skin. With a blending amount of 0.1% by mass or more, the UV protection effect can be further improved. In addition, by being 10% by mass or less, farnesol can be blended stably.

In the external preparation for skin of the present invention, as an ultraviolet protection agent, an ultraviolet scattering agent or an ultraviolet absorber is contained. The ultraviolet scattering agent and the ultraviolet absorber may be used alone, or both may be used in combination. The content of farnesol is preferably 0.5% by mass or more, and more preferably 1% by mass or more with respect to the total amount of the ultraviolet scattering agent and/or ultraviolet absorber. By being 0.5% by mass or more, the UV protection effect can be further exerted.

In addition, the external preparation for skin of the present invention may also contain polar oil. In the case of containing polar oil, the content of farnesol is preferably in the range of 2% by mass or more, and more preferably 4% by mass or more with respect to the total amount of polar oil. The scope. By being 2% by mass or more, the UV protection effect can be further exerted.

[Ultraviolet Scattering Agent] The ultraviolet scattering agent is not particularly limited as long as it is a powder used as an ultraviolet scattering agent in the field of cosmetics. Specifically, it can be selected from titanium oxide, zinc oxide, barium sulfate, iron oxide, talc, mica, sericite, kaolin, titanium mica, iron blue, chromium oxide, chromium hydroxide, silicon dioxide, cerium oxide, etc. One or more of them. In terms of optical properties, it is particularly preferable to use powders having a refractive index of 1.5 or more, such as zinc oxide, titanium oxide, and cerium oxide.

The UV-scattering agent improves the dispersibility or water resistance in oil by hydrophobizing the surface. In the present invention, it is also preferable to use a hydrophobic-treated UV-scattering agent. Surface treatment methods include: polysiloxane treatments such as methyl hydrogen polysiloxane and methyl polysiloxane; silicon dioxide treatments such as silicon dioxide and hydrous silicon dioxide; and alkane such as dextrin palmitate. Alkyl dextrin treatment; distearyl dimethyl ammonium chloride treatment; alkyl silane treatment such as octyl triethoxy silane; fluorine treatment using perfluoroalkyl phosphate, perfluoroalcohol, etc.; using N-acid Amino acid treatment such as glutamic acid; and lecithin treatment; metal soap treatment such as aluminum stearate treatment and magnesium isostearate treatment; fatty acid treatment; alkyl phosphate ester treatment, etc.

From the viewpoint of washing the skin with external preparations, it is preferable to use polysiloxane treatment such as methyl hydrogen polysiloxane and methyl polysiloxane; silicon dioxide treatment such as silicon dioxide and hydrous silicon dioxide; and chlorination Distearyl dimethyl ammonium treatment; alkyl silane treatment such as octyl triethoxy silane; and methyl hydrogen polysiloxane/methyl polysiloxane treatment, silicon dioxide/methyl polysiloxane Mixed processing such as processing.

The ultraviolet scattering agent used in the present invention is not particularly limited, and it is generally preferably one with an average primary particle diameter of 100 nm or less, and more preferably 80 nm or less. When the average primary particle size greatly exceeds 100 nm, it tends to cause whitening or residual whitening. Furthermore, the so-called average primary particle size in the present invention refers to, for example, a value obtained as the arithmetic average of the long axis and the short axis of the particle based on a transmission electron micrograph. The particle shape of the ultraviolet scattering agent is not particularly limited, and may be in the state of primary particles, or may be in the form of agglomerated secondary aggregates. In addition, the types of shapes such as a spherical shape, an elliptical shape, and a broken shape are not particularly limited.

The blending amount of the ultraviolet scattering agent is preferably in the range of 1-20% by mass, preferably in the range of 2-15% by mass, most preferably in the range of 2-10% by mass relative to the total amount of the external preparation for skin. By setting the blending amount to 1% by mass or more, a sufficient UV protection effect can be obtained, and by setting it as 20% by mass or less, it is possible to suppress unpleasant whiteness or powdery feeling during application.

[Ultraviolet absorber] The ultraviolet absorber is not particularly limited, but it is preferably selected from ultraviolet absorbers that are insoluble in water and poorly soluble in oil. Specifically, benzoic acid-based ultraviolet absorbers (for example, p-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglyceride, N,N-dipropoxy PABA ethyl ester, N,N -Diethoxy PABA ethyl ester, N,N-dimethyl PABA ethyl ester, N,N-dimethyl PABA butyl ester, diethylamino hydroxybenzyl hexyl benzoate, etc.); o-aminobenzene Formic acid-based ultraviolet absorbers (such as N-acetylanthranilic acid-3,3,5-trimethylcyclohexyl ester, etc.); salicylic acid-based ultraviolet absorbers (such as pentyl salicylate, salicylic acid) Dimethacrylate, permethylate salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, etc.); cinnamic acid UV absorbers (such as methyl Octyl oxycinnamate (ethylhexyl p-methoxycinnamate), ethyl 4-isopropyl cinnamate, methyl 2,5-diisopropyl cinnamate, 2,4-diisopropyl cinnamon Ethyl ester, 2,4-diisopropyl methyl cinnamate, propyl p-methoxycinnamate, isopropyl p-methoxycinnamate, isoamyl p-methoxycinnamate, p-methoxy Octyl cinnamate (2-ethylhexyl p-methoxycinnamate), 2-ethoxyethyl p-methoxycinnamate, cyclohexyl p-methoxycinnamate, α-cyano-β-benzene Ethyl cinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate, mono-2-ethylhexyl-di-p-methoxycinnamate, etc.); benzophenone UV absorbers (such as 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethyl Oxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4' -Methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 4'-phenyl-benzophenone-2- 2-ethylhexyl carboxylate, 2-hydroxy-4-n-octyloxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc.); 3-(4'-methylbenzylidene) -d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole ; 2-(2'-hydroxy-5'-third octylphenyl)benzotriazole; 2-(2'-hydroxy-5'-methylphenylbenzotriazole; dibenzylhydrazine; United Nations General Assembly Anisidine methyl methane; 4-Methoxy-4'-tertiary butyl dibenzyl methane; 5-(3,3-Dimethyl-2-butylidene)-3-pentane-2 -Ketones, dilinyl ketones, etc.

In addition, as the tris derivative, specifically 2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]phenyl}-6-(4- Methoxyphenyl)-(1,3,5)-tris (bisethylhexyloxyphenol methoxyphenyl tris: Tinosorb S), 2,4,6-tris[4-(2- Ethylhexyloxycarbonyl)anilino] 1,3,5-tris (ethylhexyl tris: Uvinul T150) and the like. Furthermore, as the dityl methane derivative, 4-tert-butyl-4'-methoxy dityl methane (for example, "Parsol 1789") and the like can be preferably cited. In addition, as the benzylidene camphor derivative, 3-benzylidene camphor (for example, "Mexoryl SD"; Chimex), 4-methylbenzylidene camphor, and benzylidene camphor sulfonic acid (for example "Mexoryl SL"; Chimex company), camphor benzalkonium methyl sulfate (e.g. "Mexoryl SO"; Chimex company), terephthalmethylene dicamphorsulfonic acid (e.g. "Mexoryl SX"; Chimex company), polypropylene Amidomethylbenzylidene camphor (for example, "Mexoryl SW"; Chimex Corporation) and the like.

In particular, from the viewpoint of the enhancement of the ultraviolet protection effect brought by farnesol, it is preferably selected from ethylhexyltris, 4-tertiarybutyl-4'-methoxydiphenylmethyl At least one of methane (tertiary butyl methoxy dibenzyl methane), hexyl diethylamino hydroxy benzoic acid benzoate, and diethylhexyloxyphenol methoxy phenyl tris.

The blending amount of the ultraviolet absorber is preferably in the range of 3 to 25% by mass, more preferably in the range of 3 to 20% by mass, and most preferably in the range of 5 to 15% by mass relative to the total amount of the external preparation for skin. By being 3% by mass or more, the UV protection effect can be more sufficient. In addition, by setting it as 25% by mass or less, a lighter and thinner feeling in use can be achieved.

[Polar oil] The polar oil is not particularly limited as long as it is a polar oil normally blended in cosmetics and the like. Specifically, ester oils can be preferably used, especially ester oils with an IOB value of about 0.1 to 0.5.

Specific examples of polar oils are not limited, and include: isopropyl myristate, cetyl octoate, octyl lauryl myristate, isopropyl palmitate, butyl stearate, lauric acid Hexyl ester, myristyl myristate, decyl oleate, hexyl decyl dimethyl caprylate, cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isostearic acid iso Cetyl ester, cholesterol 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, monoisostearic acid N-alkyl glycol, neopentyl glycol didecyl Ester, diisostearyl malate, glycerol di-2-heptyl undecanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, Pentaerythritol tetra-2-ethylhexanoate, glycerol tri-2-ethylhexanoate, trimethylolpropane triisostearate, cetyl-2-ethylhexanoate (2-ethylhexanoate) Cetyl caproate), 2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleyl oleate, glyceryl acetate, Palmitic acid-2-heptylundecyl ester, diisopropyl adipate, N-lauric acid-L-glutamic acid-2-octyldodecyl ester, di-2-heptyl adipate Undecyl ester, di-2-ethylhexyl sebacate, 2-hexyl decyl myristate, 2-hexyl decyl palmitate, 2-hexyl decyl adipate, sebacate Diisopropyl acid, 2-ethylhexyl succinate, etc.

The blending amount of the polar oil is preferably in the range of 0.5 to 30% by mass, and more preferably in the range of 3 to 15% by mass relative to the total amount of the external preparation for skin. By being 0.5% by mass or more, the usability can be improved. In addition, by setting it to 30% by mass or less, the stability of the external preparation for skin can be improved.

The external skin preparation of the present invention can be prepared into various dosage forms such as ointment, cream, lotion, lotion, gel, body care oil, hair care lotion, spray, sheet, etc., and when it is made into emulsified cosmetics , It can be any form of oil-in-water type or water-in-oil type.

In the external skin preparation of the present invention, the ingredients commonly used in cosmetics or pharmaceuticals and other skin external preparations, such as oils, surfactants, powders, colored materials, water, alcohols, tackifiers, chelating agents, can be appropriately formulated as needed , Polysiloxanes, oxidation inhibitors (antioxidants), moisturizers, fragrances, various medicinal ingredients, preservatives, neutralizers, pH adjusters and other optional ingredients.

Among the above optional ingredients, specific examples of oils other than polar oils include isododecane, liquid paraffin, ozokerite, squalene, paraffin, ceresin, and squalane. , Petroleum jelly, microcrystalline wax and other hydrocarbons, dimethyl polysiloxane (polydimethylsiloxane), cyclopentasiloxane, methyl phenyl polysiloxane and other polysiloxane oils, perfluorohexane , Perfluorocarbon or perfluoropolyether such as three perfluoro-n-butylamine.

Surfactants include, for example, green soaps, fatty acid soaps such as sodium laurate and sodium palmitate, higher alkyl sulfates such as sodium lauryl sulfate and potassium lauryl sulfate, POE triethanolamine lauryl sulfate, and POE Sodium lauryl sulfate and other alkyl ether sulfates, sodium lauryl sarcosinate and other N-lactosine, N-myristyl-N-methyl taurate sodium, N-coconut oil fatty acid -N-Methyl taurate sodium and other high-grade fatty acid sulfamate, POE stearyl ether phosphoric acid and other phosphate salts, monolaurin monoethanolamide POE sodium sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate Alkylbenzene sulfonates such as sulfosuccinate, linear sodium dodecylbenzene sulfonate, linear dodecylbenzenesulfonate triethanolamine and other alkylbenzene sulfonates, disodium N-stearyl glutamate, N-hard Fatty acid monosodium glutamate and other N-glyceride glutamate, hydrogenated coconut oil fatty acid sodium glycerol sulfate and other higher fatty acid ester sulfates, turkey oil and other sulfated oils, POE alkyl ether carboxylic acid, POE Alkyl allyl ether carboxylate, higher fatty acid ester sulfonate, secondary alcohol sulfate ester salt, higher fatty acid alkanolamide sulfate ester salt, sodium lauryl monoethanolamide succinate, sodium caseinate, etc. Surfactant; Alkyl trimethyl ammonium such as stearyl trimethyl ammonium chloride, lauryl trimethyl ammonium chloride, dialkyl dimethyl ammonium such as distearyl dimethyl ammonium chloride Alkylpyridinium salt, cetylpyridinium chloride, alkyl quaternary ammonium salt, alkyl dimethyl benzyl ammonium salt, alkyl isoquinolinium salt, dialkylmorpholinium salt, POE Cationic surfactants such as alkylamines, alkylamine salts, polyamine fatty acid derivatives, pentanol fatty acid derivatives, benzalkonium chloride, etc.; 2-cocoyl-2-imidazolinium hydroxide-1 -Amphoteric surfactants such as imidazoline-based surfactants such as disodium carboxyethoxylate, betaine-based surfactants such as amidobetaine and sultaine; sorbitan monooleate, sorbitan Sorbitan fatty acid esters such as monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan trioleate, etc., monocottonseed oil fatty acid glyceride, glycerol monostearate Ester, glycerol sesquioleate, glycerol monostearate malate and other glycerol polyglycerol fatty acids, propylene glycol monostearate and other propylene glycol fatty acid esters, hydrogenated castor oil derivatives, glyceryl alkyl ethers, POE- Lipophilic nonionic surfactants such as methyl polysiloxane copolymer; POE sorbitan monooleate, POE sorbitan monostearate and other POE sorbitan fatty acid esters, POE sorbitol mono POE sorbitan fatty acid esters such as laurate, POE sorbitol monooleate, POE sorbitol monostearate, POE glycerol fatty acid esters such as POE glycerol monooleate, POE glycerol distearate, etc. Class, POE monooleate, POE distearate, POE monodioleate and other POE fatty acid esters, POE lauryl ether, POE oleyl ether, POE cholesteryl esters and other POE alkyl ethers, POE octane Polyphenyl ether, POE nonylphenyl ether and other POE alkyl phenyl ethers, POE-polyoxypropylene (hereinafter referred to as POP) monobutyl POE-POP alkyl ethers such as ether, POE-POP cetyl ether, POE-POP glyceryl ether, POE castor oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil maleic acid POE castor oil hydrogenated castor oil derivatives, POE beeswax-lanolin derivatives such as POE sorbitol beeswax, coconut oil fatty acid diethanolamide, fatty acid isopropanolamide and other alkanolamides, POE propylene glycol fatty acid esters, Hydrophilic nonionic surfactants such as POE fatty amide, POE alkyl amine, sucrose fatty acid ester, alkyl ethoxy dimethyl amine oxide, etc.

As the powder, for example, mica, talc, kaolin, sericite, muscovite, phlogopite, synthetic mica, red mica, biotite, lepidolite, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (two Silicon oxide), aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, alumina, barium sulfate, iron red, iron oxide yellow, iron oxide black, cobalt oxide, ultramarine blue, iron blue, oxide Titanium, zinc oxide, titanium mica (titanium oxide coated mica), fish scale powder, bismuth oxychloride, boron nitride, red 228, red 226, blue 404, polyethylene powder, polymethyl methacrylate powder , Polyamide resin powder (nylon powder), cellulose powder, organopolysiloxane elastomer, aluminum powder, copper powder, etc.

Examples of alcohols include lower alcohols such as methanol, ethanol, propanol, and isopropanol; cholesterol, sitosterol, lanosterol, and the like.

Examples of the thickener include: gum arabic, tragacanth, polygalactose, locust bean gum, guar gum, carrageenan, pectin, agar, starch (corn, wheat, potato, rice) and other plants Macromolecules, microbial macromolecules such as dextran, triglucose, starch macromolecules such as carboxymethyl starch, methylhydroxypropyl starch, animal-based macromolecules such as collagen, casein, and gelatin, methyl fiber Cellulose, nitrocellulose, ethyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, hydroxypropyl cellulose, carboxymethyl cellulose, crystalline cellulose and other cellulose polymers, sodium alginate, seaweed Alginic acid polymer such as propylene glycol ester, vinyl polymer such as polyvinyl methyl ether, carboxyvinyl polymer, POE polymer, POE polyoxypropylene copolymer polymer, sodium polyacrylate, polyacrylamide, etc. Acrylic polymers, polyethyleneimine, cationic polymers, bentonite, aluminum magnesium silicate, synthetic laponite, lithium bentonite, silicic anhydride and other inorganic water-soluble polymers such as water-soluble polymers.

As the chelating agent, for example, citramalic acid, gluconic acid, glyceric acid, shikimic acid, cypressol, gallic acid, tannic acid, caffeic acid, ethylenediaminetetraacetic acid, ethylenediaminetetraacetic acid, Diethylene triamine pentaacetic acid, phytic acid, polyphosphoric acid, metaphosphoric acid, and their analogs, and their alkali metal salts and carboxylic acid esters.

Examples of humectants include polyethylene glycol (hereinafter referred to as PEG), propylene glycol, dipropylene glycol, 1,3-butanediol, glycerin, diglycerin, xylitol, maltitol, maltose, and D-mannitol , Glucose, fructose, sodium chondroitin sulfate, sodium hyaluronate, sodium lactate, glucosamine, cyclodextrin, etc.

As medicinal ingredients, for example, can be formulated: vitamin A oil, retinol, retinol palmitate, pyridoxine hydrochloride, benzyl nicotinate, nicotine amide, nicotinic acid dl-α-tocopherol, Vitamins such as magnesium ascorbyl phosphate, vitamin D2, dl-α-tocopherol, pantothenic acid, and biotin; anti-inflammatory agents such as azulene and glycyrrhizin; whitening agents such as arbutin, hormones such as estradiol; zinc oxide, tannic acid And other astringents; cooling agents such as L-menthol and camphor; and lysozyme hydrochloride, pyridoxine hydrochloride, sulfur, etc. Furthermore, various extracts showing various medicinal effects can be formulated. That is, it can include: houttuynia cordata extract, cork extract, licorice extract, peony root extract, peony bark extract, loofah extract, saxifrage extract, eucalyptus extract, clove extract, horse chestnut Extract, cornflower extract, seaweed extract, thyme extract, etc.

As preservatives, for example, benzoic acid, salicylic acid, parabens (methyl paraben, ethyl paraben, butyl paraben, etc.), hexadienoic acid, parachloromethane Cresol, hexachlorophenol, benzalkonium chloride, chlorhexidine chloride, trichlorodiphenylurea, photosensitizer, phenoxyethanol, etc.

In addition, 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1,3-propanediol, potassium hydroxide, potassium hydroxide can be formulated in the preparation of the present invention , Triethanolamine, sodium carbonate and other neutralizers; lactic acid, citric acid, glycolic acid, succinic acid, tartaric acid, malic acid, sodium bicarbonate, ammonium bicarbonate and other pH regulators; ascorbic acid, α-tocopherol, carotenoids And other antioxidants.

In addition, the above-mentioned components are examples and are not limited to them. In addition, these ingredients can be appropriately combined and formulated according to the formula corresponding to the desired form. [Example]

Hereinafter, the present invention will be further described in detail through examples, but the present invention is not limited to these examples. In addition, the compounding amount in the following examples, etc., means mass% unless otherwise specified.

(Example 1) The polyoxyethylene-methylpolysiloxane copolymer of cyclopentasiloxane, isododecane, polydimethylsiloxane and farnesol, and surfactants in the oils shown in Table 1, Mix with the formula shown in Table 1 (mixed liquid). In addition, in the oil (polar oil) cetyl 2-ethylhexanoate, the ultraviolet absorber bisethylhexyloxyphenol methoxyphenyl tris, ethylhexyl tris, 4-third Butyl-4'-methoxybenzyl methane and hexyl diethylamino hydroxybenzyl benzoate are heated and melted (melting liquid). Add the molten liquid to the mixed liquid and mix it, add distearyl dimethyl amine lithium bentonite as a tackifier and spherical cross-linked PMMA (Polymethyl methacrylate) as a usable powder Ester) powder and disperse it. Then, a solution mixed with water, glycerin, and ethanol is added and emulsified to obtain an emulsified cosmetic.

(Comparative example 1) Except that farnesol was not used, an emulsified cosmetic was obtained in the same manner as in Example 1. The formula and the rate of improvement are shown in Table 1.

(Lift rate) The samples of each example were coated on a PMMA substrate, and the absorbance at 280-400 nm was measured and accumulated, and the accumulated value of Comparative Example 1 was set as a relative value of 100. As shown in Table 1, the emulsified cosmetic material of Example 1 using farnesol showed a 9% increase in UV protection effect.

[Table 1] Comparative example 1 Example 1 Oil Polydimethylsiloxane 2 2 Cyclopentasiloxane 10 10 Isododecane 5 5 Cetyl 2-ethylhexanoate 25 20 Surfactant Polyoxyethylene-methyl polysiloxane copolymer 2 2 UV absorber Bis-ethylhexyloxyphenol methoxyphenyl tris 𠯤 2 2 Ethylhexyl three 𠯤 2 2 4-tert-butyl-4'-methoxybenzyl methane 1 1 Diethylamino hydroxybenzoic acid hexyl benzoate 2 2 Tackifier Distearyl dimethyl amine lithium bentonite 1 1 Usable powder Spherical cross-linked PMMA powder 5 5 moisturizer glycerin 3 3 alcohol Ethanol 10 10 water water 30 30 Lifting agent Farnesol - 5 [Farnesol/(ultraviolet absorber+ultraviolet scattering agent)]×100% - 71.4 [Farnesol/Polar Oil]×100% - 25.0 Lift rate (cumulative value of absorbance at 280-400 nm) ctrl. 109%

(Examples 2-6, Comparative Example 2) In Example 1, except that the ultraviolet scattering agent was dispersed together with the usable powder, the emulsified cosmetics of each example were obtained in the same manner as in Example 1. The lifting rate measured in the same manner as in Example 1 was taken as the relative value of Comparative Example 2, and is shown in Table 2 together with the formulation. As shown in Table 2, the emulsified cosmetics of Examples 2-6 containing farnesol showed an increase of 7-33% in UV protection.

[Table 2] Comparative example 2 Example 2 Example 3 Example 4 Example 5 Example 6 Oil Polydimethylsiloxane 18.5 18.3 18 17.5 15.5 13.5 Cyclopentasiloxane 10 10 10 10 10 10 Isododecane 10 10 10 10 10 10 Cetyl 2-ethylhexanoate 5 5 5 5 5 5 Surfactant Polyoxyethylene-methyl polysiloxane copolymer 2 2 2 2 2 2 UV absorber Bis-ethylhexyloxyphenol methoxyphenyl tris 𠯤 2 2 2 2 2 2 Ethylhexyl three 𠯤 2 2 2 2 2 2 Diethylamino hydroxybenzoic acid hexyl benzoate 2 2 2 2 2 2 UV Scattering Agent Silica microparticle titanium oxide treated with distearyl dimethyl ammonium chloride 1 1 1 1 1 1 Micronized zinc oxide treated with silicon dioxide/polydimethylsiloxane 1 1 1 1 1 1 Tackifier Distearyl dimethyl amine lithium bentonite 0.5 0.5 0.5 0.5 0.5 0.5 Usable powder Spherical cross-linked PMMA powder 5 5 5 5 5 5 moisturizer glycerin 1 1 1 1 1 1 alcohol Ethanol 10 10 10 10 10 10 water water 30 30 30 30 30 30 Lifting agent Farnesol - 0.2 0.5 1 3 5 [Farnesol/(ultraviolet absorber+ultraviolet scattering agent)]×100% - 2.5 6.3 12.5 37.5 62.5 [Farnesol/Polar Oil]×100% - 4.0 10.0 20.0 60.0 100.0 Lift rate (cumulative value of absorbance at 280-400 nm) ctrl. 107% 109% 112% 131% 133%

(Examples 7-11, Comparative Examples 3-7) Each of the ultraviolet absorbers shown in Table 3 was added to cetyl 2-ethylhexanoate or hydrogenated polydecene, and heated and melted. In Examples 7 to 11, farnesol was mixed therein. Examples 9 to 11 and Comparative Examples 5 to 7 were further mixed with ethanol to obtain cosmetics of each example. The lifting rates of Examples 7 to 11 were taken as relative values of Comparative Examples 3 to 7 for comparison, and are shown in Table 3 together with the formulation. As shown in Table 3, depending on the type of ultraviolet absorber, the increase rate of the ultraviolet protection effect is different, but the increase of the ultraviolet protection effect is seen in any cosmetics.

[table 3] Comparative example 3 Example 7 Comparative example 4 Example 8 Comparative example 5 Example 9 Comparative example 6 Example 10 Comparative example 7 Example 11 Oil Cetyl 2-ethylhexanoate Increase to 100 Increase to 100 Increase to 100 Increase to 100 Increase to 100 Increase to 100 Increase to 100 Increase to 100 Increase to 100 Increase to 100 Hydrogenated polydecene - - - - 12 12 12 12 12 12 UV absorber Ethylhexyl three 𠯤 3 3 - - - - - - - - 4 ^_tertiary butyl-4'-methoxybenzyl methane - - 3 3 3 3 - - - - Bis-ethylhexyloxyphenol methoxyphenyl tris 𠯤 - - - - - - 3 3 - - Diethylamino hydroxybenzoic acid hexyl benzoate - - - - - - - - 3 3 alcohol Ethanol - - - - 60 60 60 60 60 60 Lifting agent Farnesol - 10 - 10 - 5 - 5 - 5 [Farnesol/(ultraviolet absorber+ultraviolet scattering agent)]×100% - 333.3 - 333.3 - 166.7 - 166.7 - 166.7 [Farnesol/Polar Oil]×100% - 11.5 - 11.5 - 25.0 - 25.0 - 25.0 Lift rate (cumulative value of absorbance at 280-400 nm) ctrl. 113% c trl. 104% ctrl. 102% ctrl. 109% ctrl. 108%

The following shows a formulation example of the external preparation for skin of the present invention. Formulation example 1: Ingredients of oil-in-water sunscreen gel blending amount (mass%) purified water remaining amount ethanol 8 EDTA-2Na·H ₂ O 0.05 sodium hexametaphosphate 0.05 citric acid 0.03 sodium citrate 0.01 farnesol 0.2 transcript Acid 2 Phosphoric acid L-magnesium astaglate 0.5 Water-soluble collagen 0.1 (Dimethacrylamide/Sodium acrylate dimethyl taurate) copolymer 0.3 Succinic glycan 0.1 Stearyloxy hydroxypropyl Methyl cellulose 0.1 glycerin 3 Butylene glycol 5 Polyoxyethylene (14) Polyoxypropylene (7) Dimethyl ether 1 Polyoxyethylene hydrogenated castor oil (60 mol) 1.5 Ethylhexyl methoxycinnamate 5 Ethylhexyl tris 1 2 Ethylamino hydroxy benzoic acid hexyl benzoate 1 Diethylhexyloxy phenol methoxy phenyl tris 1 Cyclopentasiloxane 3 Polydimethylsiloxane 6 Phytosterol Australian walnut oil fatty acid Ester 1 Dextrin (palmitic acid/ethylhexanoic acid) ester 1 Microparticle zinc oxide treated with silica/polydimethylsiloxane 5 Titanium oxide treated with alumina 1 Isostearic acid 0.3 Fragrance Polyurethane ((HDI/trimethylolcaprolactone) cross-linked polymer) powder treated with silica 1 silica 1

Formulation example 2: Oil-in-water BB cream Allocation component Allocation amount (quality%) Purified water Remaining amount Ethanol 5 of the 5 EDTA·3Na 0.1% of the time. EDTA·3Na·············································································· Salt Salt 0.1 Sodium metabisulfite, 0.01 Phenoxyethanol, phenoxyethanol, phenoxyethanol, phenoxyethanol, phenoxyethanol, phenoxyethanol, 1 Glycerin ▒ ▫ 5 Erythritol Alcohol ​ Xylitol 1) Xylitol 1 Foreign vegetable extracts 1 Sodium Hyaluronate 0.1 Dipotassium glycyrrhizinate 0.05. Falcoholicity 0.1% of the time. Isopropyl myristate 2 ​ ​ Poly-dimethylsiloxane 12 ​ Cyclomethyl silicone resin 12 Cyclopentasiloxane solution of 50% trisiloxysilicic acid 2 Dextrin palmitate dextrin palmitate 1 Ethylhexyl methoxycinnamate 3 Fine particles of titanium oxide treated with stearic acid/aluminum hydroxide 3 Particulate zinc oxide treated with dextrin palmitate 3 Pigment-grade titanium oxide treated with octyltriethoxysilane 4 Iron oxide red treated with octyltriethoxysilane, moderate amount Iron oxide yellow treated with octyltriethoxysilane, moderate amount Iron oxide black treated with octyltriethoxysilane, moderate amount Polydimethylsiloxane cross-linked polymer 13% cyclopentasiloxane mixture 3 Polymethyl sesquisiloxane 3 Methyl methacrylate cross-linked polymer 3 Microparticle dimethyl silylated silicon dioxide 0.5 Lauryl PEG-9 polydimethylpolysiloxane oxyethyl polydimethylsiloxane 2 (Polydimethylsiloxane/(PEG-10/15)) Polydimethylsiloxane solution of cross-linked polymer 2 Dimethyl distearyl ammonium lithium bentonite stone 1 Isostearic acid 0.2 Tocopherols 0.01 Fragrances Right amount

Formulation example 3: Oil-in-water type sunscreen double-layer emulsion Allocation component Allocation amount (quality%) Purified water Remaining amount Ethanol 8 of the 8 EDTA・3Na 0.1% of the time. EDTA 3Na Salt of the sth sth sth 0.1 Sodium pyrosulfite ​ Silicon dioxide Glycerin Glycerin Trehalose trehalose trehalose 1 Rose dog fruit extracts 0.1% of the time. Sodium hyaluronic acid 0.1% of the time. Falcoholic I will find that it is 1 Iso-dodecane,,,, 3 Tri-2-ethylhexanoic acid glyceride 5 Isopropyl myristate 5 Diisopropyl Sebacate 10 10 PBG/PPG-9/1 Copolymer 1 Copolymer of PBG/PPG-9/1 Poly-dimethylsiloxane 9​ Trisiloxysilicic acid 50% cyclopentasiloxane solution 3 Sucrose triacetic acid tetrastearate 1 sucrose triacetic acid Dextrin palmitate ester of dextrin palmitate 1 Moliou Essences 5 Diethylamino hydroxybenzyl hexyl benzoate hexyl benzoate 0.5 0.5 Double ethyl hexoxy phenol methoxy phenyl trisyloxy phenyl triacetate 0.5 Tertiary butyl methoxybenzyl methyl methane 2.5 ​ Ethyl hexyl salicylate 5 5 Oklahoma Forestry ▫ 5 Titanium oxide processed by hydrogenated polydimethylsiloxane/aluminum hydroxide 3, ​ Particulate zinc oxide processed by octyl triethoxysilane 7 ​ Methyl methacrylate cross-linked polymer 3 🙂 🙂 (Vinyl polydimethylsiloxane/polymethylsiloxane sesquisiloxane) cross-linked polymer 3 The talc processed by calcium stearate 5 The talc treated with calcium stearate PEG-9 polydimethylpolysiloxyethyl polydimethylsiloxane 1 polydimethylsiloxane (polydimethylsiloxane) PEG-9 polydimethyl polysiloxane ethyl polydimethyl siloxane 2 ​ Lithium dimethyl bis-stearyl ammonium swelling stone 0.5 Iso stearic acid 0.3 0.3 Sorbitol anhydride fold isostearate 0.3 Tocopherols ​ ​ Fragrances Right amount of right amount

Formulation example 4: Ingredients of oil-in-water sunscreen lotion Blending amount (mass%) Purified water Remaining amount Ethanol 5 Sodium hexametaphosphate 0.01 EDTA-2Na・2H ₂ O 0.05 Micro-particle silica 0.2 Dipotassium glycyrrhizinate 0.05 Acetyl hyaluronic acid Sodium 0.1 Taurine 0.1 Glycine Glycine 0.1 Farnesol 0.1 Carbomer 0.1 (Acrylate/alkyl acrylate (C10-30) ester) Cross-linked polymer 0.1 Trixian gum 0.1 Glycerin 5 Dipropylene glycol 5 Polyoxyethylene (14) Polyoxypropylene (7) Dimethyl ether 1 Trehalose 1 Polyoxyethylene behenyl ether (20 mol) 1 Stearyl alcohol 1 Behenyl alcohol 2 Squalyl alcohol 0.3 Triethanolamine 1.5 Ethylhexyl salicylate 5 Polysiloxane-15 5 Ethylhexyl tris ⠯ 1 Diethylamino hydroxy benzoic acid hexyl benzoate 2 Diethylhexyloxy phenol methoxy phenyl tris ⠯ 2 Methylenebisbenzotriazolyl tetramethylbutylphenol 50% aqueous dispersion 1 Phenylbenzimidazole sulfonic acid 2 Diisopropyl sebacate 8 Phytosterol Australian walnut oil fatty acid ester 1 Polypropylene glycol (17) 1 Polydimethylsiloxane 6 Diphenylsilanoxyphenyl trimethicone 1 Dextrin (palmitic acid/ethylhexyl) Acid) ester 1 Phenoxyethanol 0.5 Tocopherol 0.01 Fragrance appropriate amount of cellulose powder (average particle size 5 μm) 1

Claims (14)

An external preparation for skin comprising an ultraviolet scattering agent and/or an ultraviolet absorber, and farnesol. The external preparation for skin according to claim 1, wherein the ultraviolet scattering agent is a hydrophobic treatment scattering agent. The external preparation for skin according to claim 1, wherein the ultraviolet absorber is selected from the group consisting of ethylhexyltris, 4-tert-butyl-4'-methoxydibenzylmethane, and diethylaminohydroxybenzyl At least one of hexyl benzoate and bisethylhexyloxyphenol methoxyphenyl tris. The external preparation for skin of 2 or 3, wherein the content of the farnesol is 0.1-10% by mass relative to the total amount of the external preparation for skin. The external skin preparation of 2 or 3, wherein the content of the farnesol is 0.5% by mass or more with respect to the total amount of the ultraviolet scattering agent and/or the ultraviolet absorber. The skin external preparation of claim 5, which further contains a polar oil, and the content of the farnesol is 2% by mass or more relative to the total amount of the polar oil. An external preparation for skin, which uses farnesol as an effective ingredient for enhancing UV protection. The external preparation for skin according to claim 7, wherein the content of the farnesol is 0.1-10% by mass relative to the total amount of the external preparation for skin. The external preparation for skin according to claim 7 or 8, wherein the aforementioned ultraviolet protection effect is produced by an ultraviolet scattering agent and/or an ultraviolet absorber. The external preparation for skin according to claim 9, wherein the ultraviolet scattering agent is a hydrophobic treatment scattering agent. The external preparation for skin according to claim 9, wherein the ultraviolet absorber is selected from the group consisting of ethylhexyl tris, 4-tert-butyl-4'-methoxydiphenylmethan, diethylaminohydroxybenzyl At least one of hexyl benzoate and bisethylhexyloxyphenol methoxyphenyl tris. The external preparation for skin according to claim 9, wherein the content of the farnesol is 0.5% by mass or more relative to the total amount of the ultraviolet scattering agent and/or the ultraviolet absorber. Such as the skin external preparation of claim 12, which further contains a polar oil, and the content of the farnesol is 2% by mass or more relative to the total amount of the polar oil. A method to improve the effect of UV protection, which uses farnesol.