JP7261594B2 - External preparation for skin and method for improving UV protection effect - Google Patents

Description

TECHNICAL FIELD The present invention relates to an external preparation for skin and a method for improving ultraviolet protection effect.

Sunscreen cosmetics are intended to block ultraviolet rays in sunlight and protect the skin from the harmful effects of ultraviolet rays. Even in the case of agents, in order to obtain a high SPF (Sun Protection Factor) value by blocking ultraviolet irradiation to the skin, a large amount of ultraviolet absorbers and ultraviolet scattering agents are blended. In general, a high content of oil is required in order to contain a large amount of UV absorber or UV scattering agent. In particular, it is difficult to achieve a high SPF value for oil-in-water emulsified cosmetics, which are required to have a fresh feel and good spreadability.

In order to solve such a problem, the applicant discloses in Patent Document 1 that a predetermined amount of sucrose fatty acid ester is blended, and the total amount of the oil phase is set to a certain amount or less, which is required for oil-in-water emulsified cosmetics. This patent proposes an oil-in-water emulsified cosmetic capable of suppressing stickiness and achieving a high SPF value while maintaining freshness and spreadability during use.

By the way, the applicant claims that farnesol suppresses only the growth of the harmful bacterium Staphylococcus aureus and does not affect the growth of the harmless bacterium Staphylococcus epidermidis, and that xylitol only inhibits the harmless bacterium Staphylococcus epidermidis. Based on the finding that farnesol is a nutrient source and not a nutrient source for harmful bacteria Staphylococcus aureus, a selective antibacterial composition containing farnesol and xylitol has been proposed (Patent Document 2). In addition, they have proposed an external preparation for skin that combines farnesol and tocopherol, which makes it possible to maintain the bactericidal effect for a long period of time (Patent Document 3).

Japanese Patent No. 6321105 Japanese Patent No. 4011787 Japanese Patent Application Laid-Open No. 2002-293735

As shown in Patent Documents 2 and 3, farnesol can selectively kill bacteria and has a floral-like fragrance, so it is sometimes blended in cosmetics. However, the relationship between UV absorbers and UV scattering agents has never been investigated, and the present inventors have conducted extensive studies and surprisingly found that farnesol has the effect of improving the UV protection effect. As a result, the inventors completed the present invention.

That is, the present invention was made based on the above findings, and an object thereof is to provide an external preparation for skin with improved UV protection effect and a method for improving UV protection effect.

The external preparation for skin of the present invention contains an ultraviolet scattering agent and/or an ultraviolet absorbing agent and farnesol.

The UV scattering agent is preferably a hydrophobic treatment scattering agent.

The ultraviolet absorber is preferably at least one selected from ethylhexyltriazine, 4-tert-butyl-4'-methoxydibenzoylmethane, hexyl diethylaminohydroxybenzoylbenzoate and bisethylhexyloxyphenolmethoxyphenyltriazine.

The content of farnesol is preferably 0.1 to 10% by mass based on the total amount of the external preparation for skin.

The farnesol content is preferably 0.5% by mass or more relative to the total amount of the ultraviolet scattering agent and/or the ultraviolet absorbing agent.

The external preparation for skin may further contain a polar oil, and in this case, the farnesol content is preferably 2% by mass or more relative to the total amount of the polar oil.

From another aspect, the external preparation for skin of the present invention uses farnesol as an active ingredient for improving the UV protection effect.

The content of farnesol is preferably 0.1 to 10% by mass based on the total amount of the external preparation for skin.

It is preferable that the UV protection effect is due to the UV scattering agent and/or the UV absorber.

The UV scattering agent is preferably a hydrophobic treatment scattering agent.

The ultraviolet absorber is preferably at least one selected from ethylhexyltriazine, 4-tert-butyl-4'-methoxydibenzoylmethane, hexyl diethylaminohydroxybenzoylbenzoate and bisethylhexyloxyphenolmethoxyphenyltriazine.

The farnesol content is preferably 0.5% by mass or more relative to the total amount of the ultraviolet scattering agent and/or the ultraviolet absorbing agent.

The external preparation for skin may further contain a polar oil, and in this case, the farnesol content is preferably 2% by mass or more relative to the total amount of the polar oil.

The method for improving the UV protection effect of the present invention uses farnesol.

The external preparation for skin of the present invention contains an ultraviolet scattering agent and/or an ultraviolet absorber and farnesol, or uses farnesol as an active ingredient for improving the ultraviolet protection effect. The UV protection effect can be improved as compared with external preparations for skin containing UV scattering agents and/or UV absorbers.

The present invention will be described in detail below.
The external preparation for skin of the present invention contains an ultraviolet scattering agent and/or an ultraviolet absorbing agent and farnesol. From another aspect, the external preparation for skin of the present invention uses farnesol as an active ingredient for improving the UV protection effect.
Each component will be explained in detail.

[Farnesol]
Farnesol (3,7,11-trimethyl-2,6,10-dodecatrien-1-ol) is commercially available as a synthetic fragrance with antibacterial properties and is used in cosmetics with a fresh green note and floral-like odor. may be Commercially available farnesol is synthesized directly from geraniol, and commercially available farnesol is available, for example, from Kuraray and DORAGOCO.

In the topical skin preparation of the present invention, the farnesol content is preferably in the range of 0.1 to 10% by weight, more preferably in the range of 0.1 to 5% by weight, based on the total amount of the topical skin preparation. When the blending amount is 0.1% by mass or more, the UV protection effect can be further improved. Further, farnesol can be stably blended by being 10% by mass or less.

The external preparation for skin of the present invention contains an ultraviolet scattering agent or an ultraviolet absorber as an ultraviolet protective agent. Either one of the ultraviolet scattering agent and the ultraviolet absorbing agent may be used, or two of them may be used together. The farnesol content is preferably 0.5% by mass or more, more preferably 1% by mass or more, relative to the total amount of the ultraviolet scattering agent and/or the ultraviolet absorber. When the amount is 0.5% by mass or more, the UV protection effect can be further exhibited.

In addition, the external preparation for skin of the present invention may contain a polar oil. When the polar oil is contained, the content of farnesol relative to the total amount of the polar oil is preferably in the range of 2% by mass or more, and 4% by mass or more. A range is more preferred. When it is 2% by mass or more, the UV protection effect can be further exhibited.

[Ultraviolet scattering agent]
The ultraviolet scattering agent is not particularly limited as long as it is a powder used as an ultraviolet scattering agent in the field of cosmetics. Specifically, one selected from titanium oxide, zinc oxide, barium sulfate, iron oxide, talc, mica, sericite, kaolin, mica titanium, Prussian blue, chromium oxide, chromium hydroxide, silica, cerium oxide, etc. or Two or more types are mentioned. In particular, powders having a refractive index of 1.5 or more, such as zinc oxide, titanium oxide, and cerium oxide, are preferably used from the viewpoint of optical properties.

By hydrophobizing the surface of the UV scattering agent, the dispersibility in oil and water resistance are improved, and in the present invention, a hydrophobizing UV scattering agent is preferably used.
Examples of surface treatment methods include silicone treatment with methylhydrogenpolysiloxane, methylpolysiloxane, etc.; silica treatment with silica, hydrous silica, etc.; alkyldextrin treatment with dextrin palmitate, etc.; distearyldimethylammonium chloride treatment; octyltriethoxysilane. Fluorine treatment with perfluoroalkyl phosphate, perfluoroalcohol, etc.; Amino acid treatment with N-acylglutamic acid, etc.; Other, lecithin treatment; Metal soap treatment such as aluminum stearate treatment, magnesium isostearate treatment; Examples include fatty acid treatment; alkyl phosphate treatment, and the like.

From the viewpoint of rinsing off external preparations for skin, silicone treatment such as methylhydrogenpolysiloxane and methylpolysiloxane; silica treatment such as silica and hydrated silica; distearyldimethylammonium chloride treatment; alkylsilane treatment such as octyltriethoxysilane; Hybrid treatments such as methylhydrogenpolysiloxane/methylpolysiloxane treatments and silica/methylpolysiloxane treatments are also preferred.

Although the UV scattering agent used in the present invention is not particularly limited, it is usually preferred that the average primary particle size is 100 nm or less, more preferably 80 nm or less. When the average primary particle size greatly exceeds 100 nm, it tends to cause whitening and white residue.
The average primary particle diameter in the present invention is, for example, a value obtained as an arithmetic mean of the long axis and short axis of particles from a transmission electron micrograph.
The particle shape of the ultraviolet scattering agent is not particularly limited, and may be in the form of primary particles or in the form of aggregated secondary aggregates. Also, the shapes such as spherical, elliptical, and crushed shapes are not particularly limited.

The amount of the UV scattering agent is preferably in the range of 1 to 20% by mass, preferably in the range of 2 to 15% by mass, and most preferably in the range of 2 to 10% by mass, based on the total amount of the external preparation for skin. be. When the amount is 1% by mass or more, a sufficient UV protection effect can be obtained, and when the amount is 20% by mass or less, it is possible to suppress the conspicuousness of the whiteness during application and the powdery feeling of use. .

[Ultraviolet absorber]
The UV absorber is not particularly limited, but is preferably selected from UV absorbers that are insoluble in water and poorly soluble in oil. Specifically, benzoic acid-based ultraviolet absorbers (e.g., para-aminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N,N-dipropoxy PABA ethyl ester, N,N-diethoxy PABA ethyl ester, N, N-dimethyl PABA ethyl ester, N,N-dimethyl PABA butyl ester , diethylaminohydroxybenzoyl hexyl benzoate, etc. ); anthranilic acid UV absorbers (e.g., homomenthyl-N-acetylanthranilate, etc.); (e.g., amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, etc.); ethyl-4-isopropylcinnamate, methyl-2,5-diisopropylcinnamate, ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p- methoxycinnamate, isoamyl-p-methoxycinnamate, octyl-p-methoxycinnamate (2-ethylhexyl-p-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate, glyceryl mono-2-ethylhexanoyl-diparamethoxycinnamate, etc.); , 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2′,4,4′-tetrahydroxybenzophenone, 2 -hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl -benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc.); 3-(4′-methylbenzylidene)-d,l-camphor, 3-benzylidene -d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole;2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole2-(2′-hydroxy-5′-methylphenylbenzotriazole;dibenzalazine;dianisoylmethane;4-methoxy-4′-t-butyldibenzoylmethane; 5-(3,3-dimethyl-2-norbornylidene) -3-Pentan-2-one, dimorpholinopyridazinone and the like are preferred.

Also, triazine derivatives, specifically 2,4-bis-{[4-(2-ethylhexyloxy)-2-hydroxy]phenyl}-6-(4-methoxyphenyl)-(1,3,5) -triazine ( bisethylhexyloxyphenol methoxyphenyltriazine: Tinosorb S), 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]1,3,5-triazine ( ethylhexyltriazine: Uvinal T150), etc. It is preferably mentioned.
Furthermore, the dibenzoylmethane derivative preferably includes 4-tert-butyl-4′-methoxydibenzoylmethane (eg, “Parsol 1789”) and the like.
Examples of benzylidene camphor derivatives include 3-benzylidene camphor (eg "Megizolyl SD"; Simex), 4-methylbenzylidene camphor, benzylidene camphor sulfonic acid (eg "Megizolyl SL"; Simex), methosulfate camphor. Benzalkonium (e.g., "Megizolyl SO"; Simex), terephthalylidene dicamphorsulfonic acid (e.g., "Megizolyl SX"; Simex), polyacrylamidemethylbenzylidene camphor (e.g., "Megizolyl SW"; Simex) and the like are preferred. mentioned.

In particular, from the viewpoint of improving the UV protection effect of farnesol, ethylhexyltriazine, 4-tert-butyl-4'-methoxydibenzoylmethane (t-butylmethoxydibenzoylmethane), hexyl diethylaminohydroxybenzoylbenzoate and bis It is preferably at least one selected from ethylhexyloxyphenol methoxyphenyltriazine.

The amount of the UV absorber is preferably in the range of 3 to 25% by mass, more preferably in the range of 3 to 20% by mass, and most preferably in the range of 5 to 15% by mass, based on the total amount of the external skin preparation. be. When the amount is 3% by mass or more, a more sufficient UV protection effect can be obtained. Moreover, by making it 25 mass % or less, it can be made into a lighter feeling of use.

[Polar oil]
The polar oil is not particularly limited as long as it is a polar oil that is usually blended in cosmetics and the like. Specifically, an ester oil, particularly an ester oil having an IOB value of about 0.1 to 0.5, is preferably used.

Specific examples of polar oils include, but are not limited to, isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate. , cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexylate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neo dicaprate Pentyl glycol, diisostearyl malate, glyceryl di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexate, trimethylolpropane triisostearate, pentaerythritol tetra-2-ethylhexylate, glyceryl tri-2-ethylhexate, triisostearin acid trimethylolpropane, cetyl-2-ethylhexanoate (cetyl 2-ethylhexanoate), 2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleic acid oil , acetoglyceride, 2-heptylundecyl palmitate, diisopropyl adipate, N-lauroyl-L-glutamic acid 2-octyldodecyl ester, di-2-heptylundecyl adipate, di-2-ethylhexyl sebacate, myristic acid- 2-hexyldecyl, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate and the like.

The amount of the polar oil to be blended is preferably in the range of 0.5 to 30% by mass, more preferably in the range of 3 to 15% by mass, based on the total amount of the external preparation for skin. Usability can be made favorable because it is 0.5 mass % or more. Moreover, by making it 30% by mass or less, the stability of the external preparation for skin can be improved.

The external preparation for skin of the present invention can be prepared in various dosage forms such as ointments, creams, milky lotions, lotions, gels, body oils, hair tonics, sprays and sheets. , in either oil-in-water or water-in-oil form.

The external preparation for skin according to the present invention includes ingredients that are usually used in external preparations for skin such as cosmetics and pharmaceuticals, such as oils, surfactants, powders, coloring materials, water, alcohols, thickeners, chelating agents, and silicones. , antioxidants (antioxidants), moisturizing agents, fragrances, various medicinal ingredients, preservatives, neutralizers, pH adjusters, and other optional compounding ingredients can be appropriately blended as necessary.

Among the above optional ingredients, specific examples of oils other than polar oils include isododecane, liquid paraffin, ozokerite, squalene, paraffin, ceresin, squalane, vaseline, hydrocarbons such as microcrystalline wax, and dimethylpolysiloxane. (dimethicone), silicone oils such as cyclopentasiloxane and methylphenylpolysiloxane, and perfluorocarbons and perfluoropolyethers such as perfluorohexane and triperfluoro-n-butylamine.

Examples of surfactants include soap bases, fatty acid soaps such as sodium laurate and sodium palmitate, higher alkyl sulfate salts such as sodium lauryl sulfate and potassium lauryl sulfate, POE triethanolamine lauryl sulfate, and POE sodium lauryl sulfate. Alkyl ether sulfate ester salts such as sodium lauroyl sarcosinate, N-acylsarcosic acid such as sodium lauroyl sarcosinate, sodium N-myristoyl-N-methyltaurate, higher fatty acid amide sulfonic acid such as sodium methyl taurid of coconut oil fatty acid, POE stearyl ether phosphate, etc. monolauroyl monoethanolamide POE sodium sulfosuccinate, sulfosuccinates such as sodium lauryl polypropylene glycol sulfosuccinate, sodium linadodecylbenzene sulfonate, alkylbenzene sulfonates such as triethanolamine linadodecylbenzene sulfonate, N-acyl glutamate such as disodium N-stearoyl glutamate, monosodium N-stearoyl glutamate, higher fatty acid ester sulfate salt such as hydrogenated coconut oil fatty acid sodium glycerol sulfate, sulfated oil such as funnel oil, POE alkyl ether carboxylic acid , POE alkyl allyl ether carboxylate, higher fatty acid ester sulfonate, secondary alcohol sulfate, higher fatty acid alkylolamide sulfate, lauroyl monoethanolamide sodium succinate, anionic surfactants such as sodium caseinate; Alkyltrimethylammonium salts such as stearyltrimethylammonium chloride and lauryltrimethylammonium chloride, dialkyldimethylammonium salts such as distearyldimethylammonium chloride, alkylpyridinium salts such as cetylpyridinium chloride, alkylquaternary ammonium salts, alkyldimethylbenzylammonium salts, Cationic surfactants such as alkylisoquinolinium salts, dialkylmorphonium salts, POE alkylamines, alkylamine salts, polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalkonium chloride; 2-cocoyl-2-imidazoly imidazoline-based amphoteric surfactants such as sodium hydroxide-1-carboxyethyloxy disodium salt; amphoteric surfactants such as betaine-based surfactants such as amidobetaine and sulfobetaine; sorbitan monooleate, sorbitan monoisostearate , sorbitan monolaurate, sorbitan monopalmitate, sorbitan trioleate and other sorbitan fatty acid esters, monocottonseed oil fatty acid glycerin, glycerin monostearate, glycerin sesquioleate, glycerin polyglycerin fatty acids such as glycerin monostearate malate , propylene glycol fatty acid esters such as propylene glycol monostearate, hydrogenated castor oil derivatives, glycerin alkyl ethers, POE/methylpolysiloxane copolymers and other lipophilic nonionic surfactants; POE sorbitan monooleate, POE sorbitan POE sorbitan fatty acid esters such as monostearate, POE sorbit monolaurate, POE sorbitol monooleate, POE sorbit fatty acid esters such as POE sorbitol monostearate, POE glycerin monooleate, POE glycerin distearate, etc. Glycerin fatty acid esters, POE fatty acid esters such as POE monooleate, POE distearate, POE monodioleate, POE alkyl ethers such as POE lauryl ether, POE oleyl ether, POE cholestanol ester, POE octylphenyl ether, POE nonylphenyl ether, etc. POE alkylphenyl ethers, POE/polyoxypropylene (hereinafter referred to as POP. ) POE/POP alkyl ethers such as monobutyl ether, POE/POP cetyl ether, POE/POP glycerin ether, POE castor oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil maleic acid, etc. POE castor oil hydrogenated castor oil derivatives, POE beeswax/lanolin derivatives such as POE sorbit beeswax, alkanolamides such as coconut oil fatty acid diethanolamide and fatty acid isopropanolamide, POE propylene glycol fatty acid esters, POE fatty acid amides, POE alkylamines, sucrose fatty acids Examples include hydrophilic nonionic surfactants such as esters and alkylethoxydimethylamine oxides.

Examples of powders include mica, talc, kaolin, sericite (sericite), muscovite, phlogopite, synthetic mica, red mica, biotite, lethia mica, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride ( silica), aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, aluminum oxide, barium sulfate, red iron oxide, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine blue, Prussian blue, titanium oxide, oxide Zinc, mica titanium (titanium oxide coated mica), fish phosphorus foil, bismuth oxychloride, boron nitride, red No. 228, red No. 226, blue No. 404, polyethylene powder, polymethyl methacrylate powder, polyamide resin powder (nylon powder) , cellulose powder, organopolysiloxane elastomer, aluminum powder, copper powder and the like.

Examples of alcohols include lower alcohols such as methanol, ethanol, propanol and isopropanol; cholesterol, sitosterol, lanosterol and the like.

Examples of thickeners include plant-based polymers such as gum arabic, tragacantocum, galactan, carop gum, guar gum, carrageenan, pectin, agar, and starch (corn, wheat, potato, and rice); molecules, starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch, animal-based polymers such as collagen, casein and gelatin, methylcellulose, nitrocellulose, ethylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose, carboxymethylcellulose, Cellulose polymers such as crystalline cellulose, alginic acid polymers such as sodium alginate and propylene glycol alginate, vinyl polymers such as polyvinyl methyl ether and carboxyvinyl polymer, POE polymers, POE polyoxypropylene copolymers molecules, acrylic polymers such as sodium polyacrylate and polyacrylic acid amide, polyethylenimine, cationic polymers, bentonite, magnesium aluminum silicate, laponite, hectorite, water-soluble inorganic polymers such as silicic anhydride and the like can be mentioned.

Chelating agents include, for example, citramalic acid, agaric acid, glyceric acid, shikimic acid, hinokitiol, gallic acid, tannic acid, caffeic acid, ethylenediaminetetraacetic acid, ethyleneglycoldiaminetetraacetic acid, diethylenetriaminepentaacetic acid, phytic acid, polyphosphoric acid, Metaphosphoric acid, analogues thereof and their alkali metal salts and carboxylic acid esters and the like can be mentioned.

Examples of moisturizing agents include polyethylene glycol (hereinafter referred to as PEG), propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, diglycerin, xylitol, maltitol, maltose, D-mannitol, glucose, fructose, sodium chondroitin sulfate, sodium hyaluronate, sodium lactate, glucosamine, cyclodextrin and the like.

Examples of medicinal ingredients include vitamin A oil, retinol, retinol palmitate, pyridoxine hydrochloride, benzyl nicotinate, nicotinamide, dl-α-tocopherol nicotinate, magnesium ascorbate phosphate, vitamin D2, and dl-α-tocopherol. , pantothenic acid, biotin; anti-inflammatory agents such as azulene and glycyrrhizin; whitening agents such as arbutin; hormones such as estradiol; astringents such as zinc oxide and tannic acid; ; In addition, lysozyme chloride, pyridoxine hydrochloride, sulfur and the like can be blended. Furthermore, various extracts exhibiting various medicinal effects can be blended. That is, Houttuynia cordata extract, Phellodendron bark extract, Glycyrrhiza extract, Peony extract, Botanpi extract, Loofah extract, Saxifrage extract, Eucalyptus extract, Clove extract, Horse chestnut extract, Cornflower extract, Seaweed extract, Thyme extract and the like can be mentioned.

Examples of antiseptics include benzoic acid, salicylic acid, paraoxybenzoic acid esters (methylparaben, ethylparaben, butylparaben, etc.), sorbic acid, parachlorometacresol, hexachlorophene, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide. , a photosensitive element, phenoxyethanol, and the like.

Other neutralizing agents such as 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1,3-propanediol, potassium hydroxide, potassium hydroxide, triethanolamine, sodium carbonate; lactic acid , citric acid, glycolic acid, succinic acid, tartaric acid, malic acid, sodium hydrogen carbonate, pH adjusters such as ammonium hydrogen carbonate; antioxidants such as ascorbic acid, α-tocopherol, carotenoids, etc. can be done.

In addition, the said component is an illustration and is not limited to these. In addition, these components can be blended in an appropriate combination according to the formulation according to the desired form.

EXAMPLES The present invention will be described in more detail below with reference to Examples, but the present invention is not limited to these Examples. In addition, unless otherwise specified, the blending amounts in the following examples and the like are shown in % by mass.

(Example 1)
Among the oils shown in Table 1, cyclopentasiloxane, isododecane, dimethicone and farnesol were mixed with a polyoxyethylene/methylpolysiloxane copolymer as a surfactant according to the formulation shown in Table 1 (mixed solution). Separately, oil (polar oil) cetyl 2-ethylhexanoate, ultraviolet absorbers bisethylhexyloxyphenolmethoxyphenyltriazine, ethylhexyltriazone, 4-tert-butyl-4'-methoxybenzoylmethane and diethylaminohydroxybenzoylbenzoic acid. Hexyl was added and heated to melt (solution). The dissolution liquid was added to the mixed liquid and mixed, and disteardimonium hectorite as a thickening agent and spherical cross-linked PMMA (polymethyl methacrylate) powder as a usable powder were added and dispersed therein. Then, a mixed solution of water, glycerin and ethanol was added and emulsified to obtain an emulsified cosmetic.

(Comparative example 1)
An emulsified cosmetic was obtained in the same manner as in Example 1, except that farnesol was not used. Formulations and boost rates are shown in Table 1.

(boost rate)
A sample of each example was applied to a PMMA substrate, and the absorbance at 280-400 nm was measured and integrated.
As shown in Table 1, the emulsified cosmetic composition of Example 1 using farnesol exhibited a UV protection effect increased by 9%.

(Examples 2 to 6, Comparative Example 2)
Emulsified cosmetics of each example were obtained in the same manner as in Example 1, except that the ultraviolet scattering agent was dispersed together with the usable powder. The boost rate measured in the same manner as in Example 1 is shown in Table 2 as a relative value for Comparative Example 2 together with the prescription. As shown in Table 2, the farnesol-containing emulsified cosmetics of Examples 2 to 6 exhibited a UV protection effect increased by 7 to 33%.

(Examples 7-11, Comparative Examples 3-7)
Each ultraviolet absorbent shown in Table 3 was added to cetyl 2-ethylhexanoate or hydrogenated polydecene and heated to melt. In Examples 7 to 11, farnesol was mixed with this. Examples 9-11 and Comparative Examples 5-7 were further mixed with ethanol to obtain cosmetics of each example. The boost ratios of Examples 7-11 are shown in Table 3 together with the formulation as relative values of Comparative Examples 3-7 for comparison. As shown in Table 3, although the rate of increase in the UV protection effect varied depending on the type of UV absorber, an increase in the UV protection effect was observed in all cosmetics.

Formulation examples of the external preparation for skin of the present invention are shown below.
Formulation Example 1: Oil-in-Water Sunscreen Gel Compounding Ingredients Amount (mass%)
Purified water Residual ethanol 8
EDTA- _2Na.H2O 0.05
Sodium hexametaphosphate 0.05
Citric acid 0.03
Sodium citrate 0.01
Farnesol 0.2
Tranexamic acid 2
Magnesium L-ascorbyl phosphate 0.5
Water-soluble collagen 0.1
(Dimethylacrylamide/Na acryloyldimethyltaurate) copolymer 0.3
succinoglucan 0.1
Stealoxyhydroxypropyl methylcellulose 0.1
Glycerin 3
butylene glycol 5
Polyoxyethylene (14) Polyoxypropylene (7) Dimethyl ether 1
Polyoxyethylene hydrogenated castor oil (60 mol) 1.5
Ethylhexyl methoxycinnamate 5
Ethylhexyltriazine 1
Diethylaminohydroxybenzoyl hexyl benzoate 1
bisethylhexyloxyphenol methoxyphenyltriazine 1
Cyclopentasiloxane 3
Dimethicone 6
macadamia nut oil fatty acid phytosteryl 1
(Palmitic acid/ethylhexanoic acid) dextrin 1
Silica/Dimethicone Treated Microparticulate Zinc Oxide 5
Alumina-treated titanium oxide 1
Isostearic acid 0.3
Fragrance Appropriate amount Silica-treated polyurethane ((HDI/trimethylolhexyllactone) crosspolymer) powder
1
Silica 1

Formulation Example 2: Water-in-oil type BB cream blending ingredients Blending amount (% by mass)
Purified water Residual ethanol 5
EDTA/3Na 0.1
Salt 0.1
Sodium pyrosulfite 0.01
Phenoxyethanol 1
Glycerin 5
Erythritol 1
Xylitol 1
Tormentilla Extract 1
Sodium hyaluronate 0.1
Dipotassium glycyrrhizinate 0.05
Farnesol 0.1
Isopropyl myristate 2
Dimethicone 12
Cyclomethicone 12
Cyclopentasiloxane solution of 50% trisiloxysilicic acid 2
Dextrin palmitate 1
Ethylhexyl methoxycinnamate 3
Stearic acid/aluminum hydroxide treated microparticle titanium oxide 3
Dextrin palmitate treated fine zinc oxide 3
Octyltriethoxysilane treated pigment grade titanium oxide 4
Octyltriethoxysilane-treated iron oxide red Appropriate amount Octyltriethoxysilane-treated iron oxide yellow Appropriate amount Octyltriethoxysilane-treated iron oxide black Appropriate amount Dimethicone crosspolymer 13% cyclopentasiloxane mixture 3
Polymethylsilsesquioxane 3
Methyl methacrylate crosspolymer 3
Fine particle dimethyl silylated silica 0.5
Lauryl PEG-9 Polydimethylpolysiloxyethyl dimethicone 2
(Dimethicone/(PEG-10/15)) crosspolymer dimethicone solution 2
Dimethyl distearylammonium hectorite 1
Isostearic acid 0.2
Tocopherol 0.01
Perfume Appropriate amount

Formulation Example 3: Water-in-oil type sunscreen two-layer type lotion Compounding ingredients (mass%)
Purified water Residual ethanol 8
EDTA/3Na 0.1
Salt 0.1
Sodium pyrosulfite 0.01
Silica 0.5
Glycerin 2
Trehalose 1
Canina rose fruit extract 0.1
Sodium hyaluronate 0.1
Farnesol 1
Isododecane 3
Glyceryl tri-2-ethylhexanoate 5
Isopropyl myristate 5
Diisopropyl sebacate 10
PBG/PPG-9/1 copolymer 1
Dimethicone 9
Cyclopentasiloxane solution of 50% trisiloxysilicic acid 3
Sucrose tetrastearate triacetate 1
Dextrin palmitate 1
Homosalate 5
Diethylaminohydroxybenzoyl hexyl benzoate 0.5
Bisethylhexyloxyphenol methoxyphenyltriazine 0.5
t-butyl methoxydibenzoylmethane 2.5
Ethylhexyl salicylate 5
Octocrylene 5
Hydrogen dimethicone/hydroxide Al-treated titanium oxide 3
Octyltriethoxysilane treated fine zinc oxide 7
Methyl methacrylate crosspolymer 3
(vinyl dimethicone/methicone silsesquioxane) crosspolymer 3
Calcium stearate treated talc 5
PEG-9 polydimethylpolysiloxyethyl dimethicone 1
Lauryl PEG-9 Polydimethylpolysiloxyethyl dimethicone 2
Dimethyl distearylammonium hectorite 0.5
Isostearic acid 0.3
Sorbitan sesquiisostearate 0.3
Tocopherol 0.01
Perfume Appropriate amount

Formulation Example 4: Oil-in-water sunscreen lotion compounding ingredients (% by mass)
Purified water Residual ethanol 5
Sodium hexametaphosphate 0.01
EDTA- _2Na.2H2O 0.05
Fine particle silica 0.2
Dipotassium glycyrrhizinate 0.05
Acetylated sodium hyaluronate 0.1
Taurine 0.1
Glycylglycine 0.1
Farnesol 0.1
Carbomer 0.1
(Acrylates/alkyl acrylate (C10-30)) crosspolymer 0.1
Xanthan gum 0.1
Glycerin 5
Dipropylene glycol 5
Polyoxyethylene (14) Polyoxypropylene (7) Dimethyl ether 1
Trehalose 1
Polyoxyethylene behenyl ether (20 mol) 1
Stearyl alcohol 1
behenyl alcohol 2
Batyl alcohol 0.3
Triethanolamine 1.5
Ethylhexyl salicylate 5
Polysilicone-15 5
Ethylhexyltriazine 1
Diethylaminohydroxybenzoyl hexyl benzoate 2
Bisethylhexyloxyphenol methoxyphenyltriazine 2
50% aqueous dispersion of methylenebisbenzotriazolyltetramethylbutylphenol
1
Phenylbenzimidazole sulfonic acid 2
Diisopropyl sebacate 8
macadamia nut oil fatty acid phytosteryl 1
polypropylene glycol (17) 1
Dimethicone 6
diphenylsiloxyphenyl trimethicone 1
(Palmitic acid/ethylhexanoic acid) dextrin 1
Phenoxyethanol 0.5
Tocopherol 0.01
Perfume Appropriate amount cellulose powder (average particle size 5 μm) 1

Claims (6)

An external preparation for skin containing an ultraviolet scattering agent and/or an ultraviolet absorber, farnesol , and a polar oil , wherein the farnesol content is 0.1 to 10% by mass relative to the total amount of the external preparation for skin, and the ultraviolet scattering agent and/or an external preparation for skin, wherein the farnesol content is 0.5% by mass or more relative to the total amount of the ultraviolet absorber, and the farnesol content is 2% by mass or more relative to the total amount of the polar oil. 2. The external preparation for skin according to claim 1, wherein the ultraviolet scattering agent is a hydrophobic treatment scattering agent. 1. The UV absorber is at least one selected from ethylhexyltriazine, 4-tert-butyl-4'-methoxydibenzoylmethane, hexyl diethylaminohydroxybenzoylbenzoate and bisethylhexyloxyphenolmethoxyphenyltriazine. The described topical skin preparation. An external preparation for skin containing farnesol as an active ingredient for improving the ultraviolet protection effect, wherein the ultraviolet protection effect is due to an ultraviolet scattering agent and/or an ultraviolet absorber, and the farnesol content is the total amount of the external skin preparation. 0.1 to 10% by mass of the farnesol relative to the total amount of the ultraviolet scattering agent and/or the ultraviolet absorber, and the content of the farnesol relative to the total amount of the polar oil contained is 0.5% by mass or more. An external preparation for skin, the amount of which is 2% by mass or more. 5. The external preparation for skin according to claim 4 , wherein the ultraviolet scattering agent is a hydrophobic treatment scattering agent. 4. The UV absorber is at least one selected from ethylhexyltriazine, 4-tert-butyl-4'-methoxydibenzoylmethane, hexyl diethylaminohydroxybenzoylbenzoate and bisethylhexyloxyphenolmethoxyphenyltriazine. The described topical skin preparation.