CN104039396A - PERSONAL CARE COMPOSITIONS COMPRISING A pH TUNEABLE GELLANT AND METHODS OF USING - Google Patents

Abstract

A personal care composition is disclosed comprising a pH tuneable gellant. The pH tuneable gellant has a formula of: [I] wherein R1 and R2 are aminofunctional end-groups; L1 is a backbone moiety having molecular weight from 14 to 500 g/mol; and at least one of L1, R1 or R2 comprises a pH-sensitive group; [II] wherein R5 is an aminofunctional moiety; L2 is a backbone moiety having molecular weight from 14 to 500 g/mol; and at least one of L2 or R5 comprises a pH-sensitive group; and mixtures of [I] and [II]. The personal care composition may take a variety of forms such as a leave-on composition, an emulsion, and/or comprising one or more actives or agents.

Description

The personal care composition and the using method that comprise the adjustable gellant of pH

Technical field

The personal care composition that comprises the adjustable gellant of the pH compatible with personal nursing composition is widely disclosed.

Background technology

For a long time, expectation is created to the concrete personal care composition widely that needs customization of consumer.For example, personal care composition comprises defying age lotion, aftershave lotion Oleum sesami, hair styling product, mascara etc.Yet, along with exploitation can be " general " compositions existing problems of specific product customization.The material that is suitable for a kind of compositions may be unsuitable for another kind of compositions.When attempting to build personal care composition, this is especially general.Conventionally the concrete phase choice structure agent based on being structured.If compositions comprises reactive explosive, such as anionic species that can be compound with cationic structural agent, the selection of structural agent may be restricted.Consider the pH of personal care composition, the selection of structural agent may further be restricted.Low or high pH can limit the effect of many structural agents.In addition,, for personal care composition, dermal sensation is important feature.Need enough structural agents to obtain consumer's viscosity expectation and aesthetic pleasant.Under effective content, many structural agents can cause worthless greasy or viscosity dermal sensation.Therefore, find with potential personal care composition is compatible widely, provide the acceptable structural agent attractive in appearance of consumer to have challenge simultaneously.

Summary of the invention

The various personal care compositions that comprise the adjustable gellant of pH are disclosed.The gellant that pH is adjustable has following formula:

R wherein ₁and R ₂for amino-functional end group; L ₁for thering is the main chain part of 14 to 500g/mol molecular weight; And L at least ₁, R ₁or R ₂one of comprise pH sensitive group;

R wherein ₅for amino-functional part; L ₂for thering is the main chain part of 14 to 500g/mol molecular weight, and L at least ₂or R ₅one of comprise pH sensitive group; And the mixture of [I] and [II].

Personal care composition can be leave compositions.

Personal care composition can be and comprises water, oil phase and the form of the emulsion of the adjustable gellant of pH as previously described.

Personal care composition can comprise the adjustable gellant of pH as previously described and be selected from following active substance or reagent: osamine, vitamin, control oil preparation, plant sterol, primoline compound, the agent of compacting, anti-wrinkle active substance, anti-atrophy active substance, flavonoid, N-acyl amino acid compound, retinoid, peptide, particulate matter, UV active substance, light stabilizer, the scorching agent of anti-cellulite, desquamation active substance, anti-acne active substance, antioxidant, free radical scavenger, conditioner, antiinflammatory, U.S. black active substance, skin lightening agent, plant extract, anti-microbial active matter, antifungus active substance, antibacterial substance, antiperspirant active, sensory agent, antiseptic, anti-dandruff active, affinity polymer, detersive surfactant, and their combination.

The specific embodiment

Except as otherwise noted, all percentage ratio used herein and ratio are all by the weighing scale of total composition, and all measurements are all carried out at 25 ℃.All numerical rangies be comprise end value compared with close limit; Described range limit and lower limit are capable of being combined, to form the other scope of clearly not describing.

Compositions of the present invention can comprise, substantially by or by solvent described herein and optional one-tenth, be grouped into.As used herein, " substantially by ... form " refer to that described compositions or component can comprise supplementary element, but prerequisite is described supplementary element, does not change in itself and be subject to the compositions of claims protection or the fundamental sum novel characteristics of method.

Term " personal care composition " refers to and is suitable for the compositions of local application on collenchyme.

As " applied " about compositions term used or " using " refers to compositions of the present invention is applied or spread into collenchyme for example on epidermis.

Term " collenchyme " refers to the keratic layer that contains as the outermost protective cover setting of mammal (such as people, Canis familiaris L., cat etc.), and it includes but not limited to skin, lip, hair, toenail, fingernail, epidermis, hoof etc.

Term " dermatological is acceptable " refers to that described compositions or component are applicable to contact with people's skin histology, and there is no unsuitable toxicity, incompatibility, unstability, allergic response etc.

Term " safe and effective amount " refers to and is enough to induce significantly the compound of positive beneficial effect or the amount of compositions.

As the term for reference group compound " leave " refers to compositions, be applied on collenchyme and stay on collenchyme at least 15 minutes.Leave compositions does not comprise washing-off type application, such as shampoo, cleansing milk, handwashing liquid, bath shampoo or health bath gel.Leave compositions can not basically contain clean or detersive surfactant.For example, leave compositions can comprise the cleansing surfactants that is less than 1%, is less than 0.5% cleansing surfactants or 0% cleansing surfactants.Yet when part is applied to skin, described compositions can comprise non-emulsifying or other finished surface activating agent that aims to provide any significantly clean beneficial effect.

Term " derivant " refers to ester, ether, amide, hydroxyl and/or the salt analog of related compound.

Term " becomes structure " or " structuring " refers to the structure that increases viscosity, thickening, solidifies or provide to personal care composition solid-state or crystallization.

Term " solubility " refers under the pressure of 25 ℃ and 1atm, at least about the solute of 0.1g, is dissolved in the solvent of 100mL.

the gellant that pH is adjustable

Personal care composition comprises the adjustable gellant of pH.Structural agent in the gellant usable as personal care composition that described pH is adjustable.Personal care composition can comprise approximately 0.001%, 0.01%, 0.05%, 0.1%, 0.5%, 1%, 2.5%, 5%, 7.5% or 10% to approximately 30%, 25%, 20%, 15%, 10%, 5%, 3%, 2%, 1% or 0.5% the adjustable gellant of pH.The gellant that pH is adjustable can be used for comprising water and/or the water of the solvent that is equal to water in.In the oil phase that the gellant that pH is adjustable can be used for comprising oil as herein described.

The acylamino-gellant that pH is adjustable provides personal care composition to have according to the viscosity characteristics of the pH of compositions.The acylamino-gellant that pH is adjustable comprises at least one pH sensitive group.In the time of in the adjustable acylamino-gellant of pH is added into such as the polar aprotic solvent of water, it is believed that nonionic forms viscosity and builds network, and ionic species is solubility and do not form viscosity, build network.The pH sensitive group of selecting by increasing or reduce pH(root Ju) acylamino-gellant is protonated or deprotonation.Thereby by changing the pH of solution, dissolubility and the viscosity that can control acylamino-gellant build behavior.By selecting carefully pH sensitive group, can customize the pKa of acylamino-gellant.Therefore, the selection of pH sensitive group can be used to select acylamino-gellant to build the pH of viscosity.

The acylamino-gellant that pH is adjustable has the following formula that is selected from:

R wherein ₁and R ₂for amino-functional end group; L ₁for thering is the main chain part of 14 to 500g/mol molecular weight; And L at least ₁, R ₁or R ₂one of comprise pH sensitive group;

R wherein ₅for amino-functional part; L ₂for thering is the main chain part of 14 to 500g/mol molecular weight; And L at least ₂or R ₅one of comprise pH sensitive group; And their mixture; Wherein the adjustable acylamino-gellant of pH has 1 to 30 pKa, or alternatively, 1.5 to 14 pKa." amino-functional end group " and " amino-functional part " comprises amino and acylamino-and can comprise the part that is not amino and acylamino-being read as.Suitable amino-functional end group and part illustrate hereinafter in more detail.

The acylamino-gellant that pH is adjustable comprises at least one amido functional groups, and comprises at least one pH sensitive group.The acylamino-gellant that pH is adjustable can have about 150g/mol, 300g/mol or 400g/mol to the molecular weight of about 1500g/mol, 900g/mol or 700g/mol.

In one embodiment, the adjustable acylamino-gellant of pH has lower array structure [I]:

R wherein ₁and R ₂for amino-functional end group; L ₁for thering is the main chain part of 14 to 500g/mol molecular weight; And L at least ₁, R ₁or R ₂one of comprise pH sensitive group.

L ₁preferably there is following formula:

[III] L ₁=A _a-B _b-C _c-D _d，

Wherein: be (a+b+c+d) 1 to 20; And A, B, C and D are independently selected from following linking group:

Preferably, A, B, C and D are independently selected from following linking group:

Wherein arrow indication 4 replacements at the most in indicated site, and X ^-for anion.

In certain embodiments, L ₁be selected from C2-C20, C6-C12 or C8-C10 hydrocarbyl chain.

In certain embodiments, R ₁for R ₃or r ₂for R ₄or wherein each AA independently selected from:

And R ₃and R ₄there is independently following formula:

[IV](L') _o-(L'') _q-R，

Wherein: be (o+q) 1 to 10; L' and L'' are linking group, independently selected from group identical with A, B, C and D in formula [III]; And R, R' and R'' are independently selected from being selected from following pH sensitive group:

Wherein arrow indication 4 replacements at the most in indicated site, n and m are 1 to 20 integer.

Or be selected from following non-pH sensitive group:

Make at least one of R, R' and R'' comprise pH sensitive group.Preferably, R comprises pH sensitive group.

In other embodiments, at least some R, R' and R'' are independently selected from pH sensitive group:

In certain embodiments, the adjustable acylamino-gellant of pH that has a structure [I] is characterised in that: L ₁for thering is the aliphatic linking group of 2 to 20 carbon atom main chains, [such as-(CH ₂) _n-, wherein n is selected from 2 to 20], and R ₁and R ₂the two all has following structure:

AA is preferably selected from:

Or be selected from:

And R is preferably selected from pH sensitive group:

Or be selected from:

In another embodiment, L ₁, two or more in L' and L'' are identical groups.

Be described in the adjustable acylamino-gellant molecules of pH in formula [I] with respect to L ₁entity can be symmetrical or can be asymmetric.Be not intended to bound by theory, it is believed that the adjustable acylamino-gellant molecules of symmetrical pH allows the formation of the network of more ordered structures, yet the compositions that comprises the adjustable acylamino-gellant molecules of one or more asymmetric pH can form unordered network.

In another embodiment, the adjustable acylamino-gellant of pH has structure [II]:

R wherein ₅for amino-functional part; L ₂for thering is the main chain part of 14 to 500g/mol molecular weight, and L at least ₂or R ₅one of comprise pH sensitive group;

L ₂can there is following formula:

[V] L ₂=A _a-B _b-C _c-D _d-R'''，

Wherein: be (a+b+c+d) 1 to 20; And R''' is pH sensitive group or non-sensitive group (being selected from the group identical with R'' with R, the R' of structure [I]).L ₂can be selected from C2-C20, C6-C12 or C8-C10 hydrocarbyl chain.

R ₅can there is following formula:

Wherein: AA is independently selected from the identical group of the AA with structure [I]; (e+f+g) be 0 to 20 or 1 to 3.

At least one of AA, R or R''' comprise pH sensitive group.Preferably, R comprises pH sensitive group.

In certain embodiments, the adjustable acylamino-gellant of pH that has a structure [II] is characterised in that: L ₂for thering is the aliphatic linking group of 2 to 20 carbon atom main chains, preferably-(CH ₂) _n-CH ₃, wherein n is selected from 2 to 20, and R ₅there is following structure:

Wherein each AA independently selected from:

Or be selected from:

And R is selected from pH sensitive group:

Or be selected from:

The optional table 1-3 provided below freely of acylamino-gellant that suitable pH is adjustable.

table 1: for the adjustable acylamino-gellant of the pH with structure [I] of personal care composition non-limitative example

table 2: for the adjustable acylamino-gellant of the pH with structure [I] of personal care composition non-limitative example

table 3: for the adjustable acylamino-gelling of the pH with structure [II] of personal care composition the non-limitative example of agent

By the example providing in table 1-3, the adjustable acylamino-gellant of pH with end pyridine groups (as two Pyrazinamide structures) can be particularly suited for gelling neutrality to alkaline system (that is, pH is greater than approximately 6).The adjustable acylamino-gellant of pH with terminal carboxylic acid group (as diacid structural) can be particularly suited for gelling acid system (that is, pH is less than approximately 5).The adjustable acylamino-gellant of pH with end imidazole group (as (4-(1H-imidazoles-5-yl) Benzoylamide) structure) can be particularly suited for gelling neutrality to alkaline system (that is, pH is greater than approximately 6).

In certain embodiments, in the acylamino-gellant structure that the pH of two types is adjustable, it is one of at least following that AA comprises: the alanine of alanine, Beta-alanine and replacement; Straight chain aminoalkyl carboxylic acid; Cyclic amino alkyl carboxylic acid; Aminobenzoic acid derivative; Amino butyric acid derivative; Arginine and homologue; Agedoite; Aspartic acid; To benzoyl phenylalanine; Two phenylalanine; Citrulline; Cyclopropyl alanine; Cyclopenta alanine; Cyclohexylalanine; Cysteine, cystine and derivant; DAB derivant; Diaminopropionic acid; Glutamate derivatives; Glutamine; Glycine; The glycine replacing; Histidine; Homocysteine; Indole derivatives; Isoleucine; Leucine and derivant; Lysine; Methionine; Naphthyl alanine; Nor-leucine; Norvaline; Ornithine; Phenylalanine; Cyclosubstituted phenylalanine; Phenylglycine; Nipecotic acid; Six hydrogen niacin and isonipecotic acids; Proline; Hydroxyproline; Thiazolidine; Pyridine radicals alanine; Serine; Statine and analog; Threonine; Tetrahydrochysene norharmane-3-carboxylic acid; 1,2,3,4-tetrahydroisoquinoline; Tryptophan; Tyrosine; Valine and their combination.

The acylamino-gellant molecules that pH is adjustable also can comprise blocking group, preferably 1 to 2 blocking group, preferably two blocking groups.The example of suitable blocking group is provided in " Protecting Groups ", P.J.Kocienski, ISBN3131356014, Georg Thieme Verlag, Stutgart; " Protective Groups in Organic Chemistry ", T.W.Greene, P.G.M.Wuts, ISBN0-471-62301-6, John Wiley & Sons, Inc, New York.

The acylamino-gellant that pH is adjustable, in personal care composition, under the target pH of compositions, can have about 0.1mg/mL or 0.5mg/mL to the MGC (MGC) of about 100mg/mL, 25mg/mL or 10mg/mL according to MGC method of testing.As used herein, MGC can mg/mL or is represented with wt%, and wherein wt% is calculated as MGC in mg/mL divided by 10.In one embodiment, MGC is at least 0.1mg/mL of the adjustable acylamino-gellant of pH, at least 0.3mg/mL, at least 0.5mg/mL, at least 1.0mg/mL, at least 2.0mg/mL, at least 5.0mg/mL.

For more strong structuring is provided, personal care composition can comprise the mixture of the adjustable gellant structural agent of two or more pH.This type of mixture can comprise the gellant structural agent that pH is adjustable, and it has different dissolubility in the carrier of wanting to be structured or solvent.

personal care composition

The acylamino-gellant that one or more aforementioned pH are adjustable can be incorporated in personal care composition.Personal care composition can be skin nursing, antiperspirant, deodorizer, beauty treatment or hair care product.Personal care composition can be used as, and for example wetting agent, conditioner, anti-senescence compounds, skin highlight agent, sunscreen, U.S. black dose of imitative solarization, shaving preparation, lip pomade, foundation cream, mascara, aftershave lotion and their combination.In certain embodiments, described compositions is applied to face, cervical region, hand, arm and other body region conventionally exposing.

Personal care composition can relate to various forms.Nonrestrictive example comprises simple solution (as water base or oil base), dispersion and emulsion.Personal care composition can be substantially anhydrous." substantially anhydrous " refers to that compositions comprises the water that is no more than approximately 1%, 0.5% or 0%.Personal care composition can be fluid or solid (gel, club, flowable solid, amorphous materials).In certain embodiments, the form that personal care composition is emulsion.Emulsion generally can be categorized as and there is continuous water (as, oil-in-water and W/O/W) or oil-continuous phase (as, Water-In-Oil and Water-In-Oil bag oil).

In certain embodiments, personal care composition has about 5NTU to the turbidity that is less than about 3000NTU, 1000NTU, 500NTU or 100NTU.

In the embodiment selecting, personal care composition can be comprise that at least one is discrete, visually different first-phase and at least one form discrete, visually different second-phase.Embodiment for these selections, " visually different " refers to that described phase can be regarded respectively by human eye as the region (that is, the dispersion of non-emulsion or granule) of obvious separation.In one embodiment, at least one forms stable pattern transparent in mutually, for example continuous or discrete line, spiral, curve or other geometry, wherein " ... interior " refer to that a phase surrounded by other phase substantially, and the sidewall of contacting container not.Alternatively, described phase can form whirlpool shape pattern, two kinds of sidewalls of ground contacting container that alternate wherein, and wherein when seeing through the sidewall observation of transparent vessel, the width substantial constant of each phase, but can differ from one another.Alternatively, described phase can form marbling shape pattern, the sidewall of the ground contacting container that wherein alternates, and wherein when seeing through the sidewall of transparent vessel and observe, the width of various phases can spread all over whole compositions variation.In one embodiment, first-phase is transparent, clarification or translucent water, and second-phase is opaque white or painted nonaqueous phase.In another alternative embodiment, at least one water can form pattern in nonaqueous phase.Have realized that compositions optionally comprises three kinds or more kinds of visually different and stable phase.Discrete, visually different heterogeneous compositions is described in U.S. Patent Application Publication 2007/0297996,2004/0057920 and 2004/0219119.

carrier

Personal care composition can comprise one or more carriers.Carrier can and/or be selected with the compatibility that is present in other material in personal care composition according to various stability, aesthetic property.

Suitable carrier comprises the solvent of water and/or water equivalence.Personal care composition can comprise the solvent of approximately 1% water to approximately 95 % by weight and/or water equivalence.Compositions can comprise approximately 1%, 3%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85% or 90% to approximately 90%, 85%, 80%, 75%, 70%, 65%, 60%, 55%, 50%, 45%, 40%, 35%, 30%, 25%, 20%, 15%, 10% or 5% water and/or the solvent of water equivalence." solvent of water equivalence " refers to be had and the compound of water to the similar ability of material solubilising.The solvent of suitable water equivalence comprises that monohydric alcohol, dihydroxylic alcohols, polyhydric alcohol, glycerol, glycol, poly alkylene glycol are such as Polyethylene Glycol and their mixture.Especially suitable solvent comprises rudimentary aliphatic alcohol, such as ethanol, propanol, butanols, isopropyl alcohol, glycol, such as 1,2-PD, 1,3-PD, butanediol, pentanediol, hexanediol, heptandiol, decanediol, glycerol, water and their mixture.In certain embodiments, personal care composition comprises water, glycol, glycerol and their combination.

Suitable carrier also comprises oil.Personal care composition can comprise one or more oil of approximately 1% to approximately 95 % by weight.Compositions can comprise one or more oil of approximately 1%, 3%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85% or 90% to approximately 90%, 85%, 80%, 75%, 70%, 65%, 60%, 55%, 50%, 45%, 40%, 35%, 30%, 25%, 20%, 15%, 10% or 5%.Oil can be used to solubilising, dispersion or carry the material of the solvent that is unsuitable for water or water equivalence.Suitable oil comprises siloxanes, hydrocarbon, ester, fatty acid amide, ether and their mixture.Oil at room temperature can be fluid.Yet some personal care product's form (being solid or semi-solid club) may need nonfluid oil.Described oil can be volatile or nonvolatile." nonvolatile " refers at 25 ℃, shows the material of the vapour pressure that is no more than about 0.2mm Hg under an atmospheric pressure, and/or have the material at least about 300 ℃ of boiling points under an atmospheric pressure." volatile " refers to that material shows the vapour pressure at least about 0.2mm mercury column at 20 ℃.When thick and heavy, greasy film is while being worthless, ethereal oil can be used to the sensation that provides light.

Suitable oil comprises ethereal oil.In certain embodiments, ethereal oil can have the range of viscosities of 25 ℃ of approximately 0.5 to approximately 5 centistokes.Ethereal oil can be used to promote skin care compositions to be dried quickly after being applied to skin.Nonvolatile oil is also applicable in compositions.Nonvolatile oil is often used to skin moistening and protective value.Nonvolatile oil preferably can have approximately 5 to approximately 800,000cst(or larger) or approximately 20 to approximately 200, the range of viscosities of 000cst.

Suitable silicone oil comprises polysiloxanes.At 25 ℃, polysiloxanes can have approximately 0.5 to approximately 1,000, the viscosity of 000 centistoke.This type of polysiloxanes can be by general chemical formulation:

R ₃SiO[R ₂SiO] _xSiR ₃

Wherein R is independently selected from hydrogen or C _1-30straight or branched, saturated or undersaturated alkyl, phenyl or aryl, trialkylsiloxy; And x is 0 to approximately 10,000 integer, it is selected to obtain the molecule of expectation.In certain embodiments, R is hydrogen, methyl or ethyl.The polysiloxanes of commercially available acquisition comprises polydimethylsiloxane, and it is also called dimethyl siloxane, and its example comprises the DM-Fluid series that derives from Shin-Etsu, by Momentive Performance Materials Inc., is sold series, and sold by Dow Corning Corporation 200 series.The object lesson of suitable polydimethylsiloxane comprises (the also conduct of 200 fluids viscosity PMX-200Silicone Fluids sale), with 0.65,1.5,50,100,350,10,000,12,500,100,000 and 300,000 centistokes.

Suitable dimethyl siloxane comprises by those of following chemical formulation:

R ₃SiO[R ₂SiO] _x[RR’SiO] _ySiR ₃

Wherein R and R ' are hydrogen or C independently of one another _1-30straight or branched, saturated or undersaturated alkyl, aryl or trialkylsiloxy; And x and y respectively do for oneself 1 to 1,000,000 integer, it is selected to obtain the molecular weight of expectation.Suitable siloxanes comprises phenyl dimethyl siloxane (Botansil ^tMpD-151, derive from Botanigenics, Inc.), diphenyl dimethyl siloxane (KF-53 and KF-54, derive from Shin-Etsu), Silicone DC 556 (556Cosmetic Grade Fluid, derive from Dow Corning) or trimethylsiloxy phenyl dimethyl siloxane (PDM-20, PDM-200 or PDM-1000, derive from Wacker-Belsil).Other example comprises alkyl-dimethyl radical siloxane, and wherein at least R ' is that aliphatic alkyl is (as C _12-22).Suitable alkyl-dimethyl radical siloxane is cetyl dimethyl siloxane, and wherein R ' is straight chain C 16, and R is methyl.Cetyl dimethyl siloxane, derives from Dow Corning with trade name 2502Cosmetic Fluid, or derives from Evonik Goldschmidt GmbH with Abil Wax9801 or 9814.

Annular siloxane is that a class can be used for the silicone oil in compositions.This type of siloxanes has general formula:

Wherein R is independently selected from hydrogen or C _1-30straight or branched, saturated or undersaturated alkyl, phenyl or aryl, trialkylsiloxy and their mixture; And n=3-8 wherein.Usually, use the mixture of cyclohexyl methyl siloxanes, wherein n is 4,5 and/or 6.The cyclohexyl methyl siloxanes of commercially available acquisition comprises that Dow Corning UP-1001Ultra Pure Fluid(is n=4), Dow Corning pMX-0245(is n=5), Dow Corning pMX-0245(is n=6), Dow Corning245 fluid (being n=4 and 5) and Dow Corning345 fluid (being n=4,5 and 6).

Other silicone oil being applicable in personal care composition comprises the polymer with following general formula:

(R ₁) _aG _3-a-Si-(-OSiG ₂) _n-(-OSiG _b(R ₁) _2-b) _m-O-SiG _3-a(R ₁) _a

Wherein G is hydrogen, phenyl, hydroxyl or C ₁-C ₈alkyl, preferable methyl; A is the number of 0-3; B is 0 or 1, preferably 1; N is 0 to 1,999 number (alternatively, 49 to 499); M is 1 to 2,000 integer (alternatively, 1 to 10); N and m's and be 1 to 2,000 number (alternatively, 50 to 500); R ₁for meeting general formula (CH ₂) _qthe univalent perssad of L, wherein q is the integer with 1 to 8 value, and L is selected from following groups:

-N(R ₂)CH ₂-CH ₂-N(R ₂) ₂

-N(R ₂) ₂

-N(R ₂) ₃A ^-

-N(R ₂)CH ₂-CH ₂-NR ₂H ₂A ^-

R wherein ₂for hydrogen, phenyl or aryl, or saturated hydrocarbyl, preferably, about C ₁to about C ₂₀alkyl, and A ^-for halogen ion.Exemplary silica alkane polymer be trimethyl silyl ammonia for dimethyl siloxane, as shown in the formula shown in:

Another exemplary silica alkane polymer is expressed by the following formula:

R wherein ³for C ₁-C ₁₈monovalence alkyl, preferred alkyl or thiazolinyl, such as methyl; R ₄for hydrocarbon, preferred C ₁-C ₁₈alkylidene or C ₁₀-C ₁₈alkylene oxide group, more preferably C ₁-C ₈alkylene oxide group; Q ^-for halogen ion, preferred chlorine; R is 2 to 20 assembly average, preferably 2 to 8; S is 20 to 200 assembly average, preferably 20 to 50.This suitable base polymer is called as UCARE SILICONE ALE56 ^tM, purchased from Union Carbide.Other suitable silicone compositions is disclosed in U.S. Patent Application Publication 2007/0039103A1.

Suitable hydrocarbon ils comprises alkane and the alkene of straight or branched.Can the functional properties based on expectation select chain length such as volatility.Suitable hydrocarbon ils can have carbon atom between 5-20 or alternatively, the carbon atom between 8-16.Suitable hydrocarbon comprises pentane, hexane, heptane, decane, dodecane, the tetradecane, tridecane and C _8-20isoparaffin, as United States Patent (USP) 3,439, disclosed in 088 and 3,818,105.Suitable hydrocarbon comprises isobutyltrimethylmethane., Fancol ID, 2-Methylpentadecane, with trade name derive from the Isoeicosane of Permethyl Corporation.Suitable hydrocarbon ils can have the carbon atom that is greater than approximately 20.The example of this type of hydrocarbon ils comprises C _24-28alkene, C _30-45alkene, C _20-40isoparaffin, Parleam, polyisobutylene, poly decene, hydrogenated polydecene, mineral oil, pentahydro-Squalene, Squalene, squalane and their mixture.

Other suitable oil comprises ester.Suitable ester comprises at least 10 carbon atoms conventionally.These esters comprise the ester (for example monoesters, polyol ester and dicarboxylic ester and tricarboxylic ester) having derived from the hydrocarbyl chain of fatty acid or alcohol.The alkyl of its ester can comprise or have other the compatible functional group with its covalent bonding, such as amide and alkoxyl part (such as ethyoxyl or ehter bond etc.).Exemplary ester includes but not limited to IPIS, lauric acid hexyl ester, lauric acid dissident ester, Palmic acid dissident ester, isopropyl palmitate, decyl oleate, Ceraphyl 140A, cetyl stearic, stearic acid ester in the last of the ten Heavenly stems, IPIS, adipic acid dihexyl ester in the last of the ten Heavenly stems, Lauryl lactate, Tetradecyl lactate, lactic acid cetyl, stearic acid oil base ester, oleic acid oil base ester, myristic acid oil base ester, lauryl acetate, propanoic acid cetyl and adipic acid oil base ester.Other suitable ester is further described in the International Cosmetic Ingredient Dictionary and Handbook of Personal Care Product Council, and the 13 edition, 2010, under the functional category of " Esters ".

Be applicable to other ester in personal care composition comprise general formula R ' the monocarboxylate of COOR, wherein R ' and R are straight or branched, saturated or undersaturated alkyl, aryl, and wherein the carbon atom in R' and R and be at least 10, suitable monoesters is benzoic acid alkyl ester, such as benzoic acid C12-15 Arrcostab.

Be applicable to dialkyl group and trialkyl and alkenyl esters that other ester in personal care composition comprises carboxylic acid, such as C ₄-C ₈the ester of dicarboxylic acids is (as C ₁-C ₂₂ester, preferably C ₁-C ₆succinic acid, 1,3-propanedicarboxylic acid and adipate ester).The concrete non-limitative example of the dialkyl group of carboxylic acid and trialkyl and alkenyl esters comprises stearyl stearic acid isocetyl ester, diisopropyl adipate, dibutyl adipate and the stearic alcohol ester of citric acid three.

Other ester being applicable in personal care composition comprises those that are called polyol ester.This type of polyol ester comprises alkylene glycol ester, such as mono fatty acid and difatty acid glycol ester, mono fatty acid and difatty acid diethylene glycol ester, mono fatty acid and difatty acid macrogol ester, mono fatty acid and difatty acid propylene glycol ester, single oleic acid polypropylene glycol ester, monostearate polypropylene glycol 2000 esters, monostearate ethoxylation propylene glycol ester, mono fatty acid and difatty acid glyceride, polyglycerol fatty acid polyglycerin ester, monostearate ethoxylated glycerol ester, monostearate 1, 3-butanediol ester, distearyl acid 1, 3-butanediol ester, polyol fatty acid polyoxyethylene ester, sorbitan esters of fatty acids and aliphatic acid polyethenoxy Isosorbide Dinitrate.

Other ester being also applicable in personal care composition comprises glyceride, includes but not limited to monoglyceride, diglyceride and triglyceride, preferably glycerine diester and triglyceride, more preferably triglyceride.For for compositions as herein described, glyceride is preferably glycerol and long-chain carboxylic acid such as C ₁₀-C ₂₂the monoesters of carboxylic acid, diester and three esters.The material of multiple these types can obtain from vegetable and Animal fat and oil, such as Oleum Ricini, safflower oil, Oleum Gossypii semen, Semen Maydis oil, olive oil, cod liver oil, almond oil, American Avocado Tree oil, Petiolus Trachycarpi oil, Oleum sesami, Semen pruni armeniacae oil, Apricot kernel oil, cameline oil, rapeseed oil, ocean Hu Oleum Verniciae fordii, Semen Lini oil, Oleum Cocois, lanolin oil, Semen sojae atricolor wet goods.Artificial oil includes but not limited to triolein and two lauric acid glyceryl tristearates.Other glyceride of fatty acid comprises the monoglyceride of fatty acid, diglyceride and triglyceride, its natural fat or oil for being modified, such as tristerin, two isostearic acid two glyceride, isostearic acid polyglyceryl-3 ester, isostearic acid polyglyceryl-4 ester, castor oil acid polyglyceryl-6 ester, glyceryl dioleate, two glyceryl isostearates, four glyceryl isostearates, tricaprylin, distearyl acid two glyceride, glyceryl linoleate, myristin, glyceryl isostearate, PEG Oleum Ricini, oleic acid PEG glyceride, stearic acid PEG glyceride, tallow fatty acid PEG glyceride etc.

Other suitable oil comprises aliphatic amide.Aliphatic series amide comprises having amide functional group, is liquid and water-fast compound at 25 ℃ simultaneously.In certain embodiments, aliphatic amide can have general formula:

Wherein R1 is optionally functionalised aliphatic series, alicyclic or ring-type, and saturated or undersaturated monovalence alkyl, comprises 1 to 30 carbon atom (1 to 22 carbon atom alternatively); R2 that can be identical or different, R3 and R4 are hydrogen or optionally functionalised aliphatic series, alicyclic or ring-type, and saturated or undersaturated monovalence alkyl, comprises 1 to 30 carbon atom, preferably 1 to 22 carbon atom; R is 0 or 1; Q is 0 to 2 integer; And p equals 0 or 1.Concrete aliphatic amide comprises N-acetyl group-N-butyl aminopropionate, N-Hamposyl L isopropyl ester and N, N ,-diethyl toluamide.Other suitable aliphatic amide is disclosed in United States Patent (USP) 6,872, in 401.

Other suitable oil comprises ether.Suitable ether comprises the saturated of polyhydric alcohol and unsaturated fatty acids ether and alkoxy derivative thereof.Exemplary ether comprises the C of polypropylene glycol _4-20alkyl ether and two C _8-30alkyl ether.The suitable example of these materials comprises PPG-14 butyl ether, Arlamol E, dioctyl ether, dodecyl octyl ether and their mixture.

emulsifying agent

Personal care composition can comprise emulsifying agent.If during when the compositions form that is emulsion or by immiscible combination of materials, emulsifying agent is especially suitable.Skin care compositions can comprise approximately 0.05%, 0.1%, 0.2%, 0.3%, 0.5% or 1% to approximately 20%, 10%, 5%, 3%, 2% or 1% emulsifying agent.It is non-ionic, anion or cationic that emulsifying agent can be.The non-limitative example of emulsifying agent is disclosed in United States Patent (USP) 3,755, and 560, in the Emulsifiers and Detergents of United States Patent (USP) 4,421,769 and McCutcheon, 2010 annuals, are published by M.C.Publishing Co..Other suitable emulsifying agent is further described in the InternationalCosmetic Ingredient Dictionary and Handbook of Personal Care Product Council, the 13 edition, 2006, under the functional category of " Surfactants-Emulsifying Agents ".

Suitable emulsifying ether and ester comprise:

Saturated or the undersaturated C of the ether of Polyethylene Glycol and fatty alcohol-comprise _12-30alcohol (as oleyl alcohol, spermol, stearyl alcohol or behenyl alcohol) and Polyethylene Glycol, the oxyalkylene group that described Polyethylene Glycol comprises n number, the integer of n=1 to 200 wherein, or alternatively, 2 to 30 integer (as 1 to 20 oxyethylene group group).Concrete example comprises having the compound that INCI name is called stearyl polyoxyethylene ether-n, mountain Yu base polyoxyethylene ether-n or oil base polyoxyethylene ether-n.Suitable example comprises having the compound that INCI name is called stearyl polyoxyethylene ether-8, stearyl polyoxyethylene ether-10, stearyl polyoxyethylene ether-16, stearyl polyoxyethylene ether-20, cetyl polyoxyethylene ether-10, laureth-4, laureth-3, tridecyl polyoxyethylene ether-6, cetearyl polyoxyethylene ether-5, oil base polyoxyethylene ether-10 and Yu base polyoxyethylene ether-10, mountain.

Polyethylene Glycol and fatty acid Zhi – comprise saturated or undersaturated C _12-30fatty acid (as oleic acid, Palmic acid, stearic acid) and Polyethylene Glycol, the oxyalkylene group that described Polyethylene Glycol comprises n number, the integer of n=1 to 200 wherein, or alternatively, 1 to 50 integer (as 1 to 20 oxyethylene group group).Concrete example comprises having the compound that INCI name is called PEG-n stearate or PEG-n oleate.Suitable example comprises PEG-8 monostearate, Polyethylene Glycol-10 or Polyethylene Glycol-12 distearate.

Glycosylation Polyethylene Glycol and fatty acid Zhi – comprise the C with 1 to 10 glycosyl _12-30alcohol and Polyethylene Glycol, the oxyalkylene group that described Polyethylene Glycol comprises n number, the wherein integer of n=1 to 200 (as 1 to 20 oxyethylene group group).Suitable example comprises polyoxyethylene (20OE) methyl glucoside distearate.

The ester of glycosylation Polyethylene Glycol and fatty acid-the comprise C with 1 to 10 glycosyl _12-30fatty acid and Polyethylene Glycol, the oxyalkylene group that described Polyethylene Glycol comprises n number, the wherein integer of n=1 to 200 (as 1 to 20 oxyethylene group group).

C _12-30the ether of alcohol and glycerol or polyglycereol-suitable example comprises polyglyceryl-3 cetyl ether, such as the Chimexane NL that derives from Chimex.

C _12-30the ester – of fatty acid and glycerol or polyglycereol comprises the ester that comprises 1 to 10 glycerol group.Concrete example comprises monostearate six glyceride, distearyl acid two glyceride, three stearic acid four glyceride, ten stearic acid ten glyceride, monostearate two glyceride, three stearic acid six glyceride, the five kinds of stiffness in infant fat acid ten glyceride, glycerol and Palmic acid and stearic ester and single (behenic acid) glyceride and two (behenic acid) glyceride.

The C of oxyalkylene modification _12-30the ether of the ether of alcohol and glycerol or polyglycereol.

C _12-30the ether of fatty alcohol and sucrose or glucose-suitable example comprises that having INCI name is called C12-18 alkyl androstanediol, C12-20 alkyl androstanediol (as derive from Seppic Montanov L), cetearyl glucoside (as the mixture with cetearyl alcohol, with reference to deriving from the Montanov68 of Seppic), myristyl glucoside is (as the mixture with myristyl alcohol, with reference to deriving from the Montanov14 of Seppic) or the compound of cetearyl glucoside (as derive from Evonik Goldschmidt Tegocare CG90)

Sucrose ester and C _12-30the concrete example of fatty acid Zhi – comprises sucrose distearate or sucrose tristearate, sucrose cocos nucifera oil acid esters, sucrose dilaurate, sucrose distearate, sucrose six eruciates, sucrose six cetylates, Surfhope SE Cosme C 1216, sucrose is by spore vegetable oil acid esters, Sucrose myristate, sucrose oleate, sucrose palmitate, sucrose five eruciates, the many behenates of sucrose, sucrose gathers Semen Gossypii acid esters, the many laurates of sucrose, the many linoleates of sucrose, sucrose polyoleate, the many cetylates of sucrose, the much Oleum Glycines acid esters of sucrose, Sucrose Polystearic Acid Esters, sucrose-ricinoleic acid ester, sucrose stearate, sucrose tetraoctyl stearate and sucrose trilaurin.Suitable example comprises the mixture of the ester (monoesters and polyester) of stearic acid and sucrose, by Croda, with Crodesta Fl10, is sold.

Tetramethylolmethane and C _12-30the ester of fatty acid-concrete example comprises pentaerythritol tetrastearate.

Sorbitol and/or anhydro sorbitol and C _12-30the ester of fatty acid-concrete example comprises monostearate Isosorbide Dinitrate, three stearic acid Isosorbide Dinitrates or lauric acid Isosorbide Dinitrate, such as the Span20 that derives from Uniqema,

The ether of sorbitol and/or anhydro sorbitol and alkoxylate anhydro sorbitol-suitable example comprises sorbitol polyethers-8 Cera Flava or sorbitol polyethers-20 Cera Flava that derives from Nikko Chemical.

The ether of Polyethylene Glycol and cholesterol-concrete example comprises that cholesterol polyethers-3, cholesterol polyethers-10(are such as Emalex CS-10, derive from Nihon Emulsion Company), cholesterol polyethers-15(is such as Emalex CS-15, derive from Nihon Emulsion Company) or cholesterol polyethers-20(such as Emalex CS-20, derive from Nihon Emulsion Company).

C _12-30the ester of the alkoxylated ether of fatty acid and sorbitol and/or, suitable example comprises polysorbate-60, polysorbate-61, sorbitol polyethers-3 isostearate, polyoxyethylene 4OE monostearate Isosorbide Dinitrate and polyoxyethylene 20OE Arlacel-65.

Also can use the silicone emulsifiers of straight chain or branching type.Especially available polyether-modified siloxanes comprises KF-6011, KF-6012, KF-6013, KF-6015, KF-6015, KF-6017, KF-6043, KF-6028 and the KF-6038 that derives from Shin Etsu.Also especially available is straight chain or the branched silicone emulsifying agent of multiglycerolifying, comprises KF-6100, the KF-6104 and the KF-6105 that derive from Shin Etsu.Exemplary material comprises the material with following international cosmetic raw material name (INCI) title: two-(butyl dimethyl siloxane) polyglyceryl-3, two-PEG/PPG-14/14 dimethyl siloxane, two-(butyl dimethyl siloxane) polyglyceryl-3, two-isobutyl group PEG/PPG-10/7 dimethylsiloxane copolymer, two-PEG/PPG-18/6 dimethyl siloxane, two-PEG/PPG-20/20 dimethyl siloxane, two-PEG/PPG-16/16PEG/PPG-16/16 dimethyl siloxane, two (PPG-7 undecylenic alcohol polyethers-21-dimethyl siloxanes, cetyl dimethyl siloxane PEG-7 acetas, cetyl PEG-8 dimethyl siloxane, cetyl PEG/PPG-15/16 butyl ether dimethyl siloxane, cetyl PEG/PPG-15/15 butyl ether dimethyl siloxane, cetyl PEG/PPG-7/3 dimethyl siloxane, cetyl PEG/PPG-10/1 dimethyl siloxane, dimethyl siloxane PEG-15 acetas, dimethyl siloxane PEG-7 cocos nucifera oil acid esters, dimethyl siloxane PEG-7 phosphate, dimethyl siloxane PEG-IO phosphate, dimethyl siloxane PEG/PPG-7/4 phosphate, dimethyl siloxane PEG/PPG-12/4 phosphate, dimethyl siloxane PEG-7 undecylenate, lauryl dimethyl siloxanes PEG-IO phosphate, different polyglyceryl-3 dimethyl siloxane, different polyglyceryl-3 dimethyl silica alkanol, iso stearyl carboxy decyl PEG-8 dimethyl siloxane, lauryl methyl siloxanes PEG-10 phosphate, lauryl PEG-8 dimethyl siloxane, lauryl PEG-10 methyl ether dimethyl siloxane, lauryl PEG/PPG-18/18 methylsiloxane, PEG-6 methyl ether dimethyl siloxane, PEG-7 methyl ether dimethyl siloxane, PEG-9 methyl ether dimethyl siloxane, PEG-10 methyl ether dimethyl siloxane, PEG-11 methyl ether dimethyl siloxane, PEG-11 methyl ether dimethyl siloxane, PEG-32 methyl ether dimethyl siloxane, PEG-PEG/PPG-28/21 acetas dimethyl siloxane, PEG/PPG-22/22 butyl ether dimethyl siloxane, PEG/PPG-23/23 butyl ether dimethyl siloxane, PEG/PPG-24/18 butyl ether dimethyl siloxane, PEG/PPG-3/10 dimethyl siloxane, PEG/PPG-4/12 dimethyl siloxane, PEG/PPG-6/11 dimethyl siloxane, PEG/PPG-8/14 dimethyl siloxane, PEG/PPG-12/16 dimethyl siloxane, PEG/PPG-12/18 dimethyl siloxane, PEG/PPG-14/4 dimethyl siloxane, PEG/PPG-15/5 dimethyl siloxane, PEG/PPG-15/15 dimethyl siloxane, PEG/PPG-16/2 dimethyl siloxane, PEG/PPG-16/8 dimethyl siloxane, PEG/PPG-17/18 dimethyl siloxane, PEG/PPG-18/12 dimethyl siloxane, PEG/PPG-19/19 dimethyl siloxane, PEG/PPG-20/6 dimethyl siloxane, PEG/PPG-20/15 dimethyl siloxane, PEG/PPG-20/20 dimethyl siloxane, PEG/PPG-20/29 dimethyl siloxane, PEG/PPG-22/23 dimethyl siloxane, PEG/PPG-22/24 dimethyl siloxane, PEG/PPG-25/25 dimethyl siloxane, PEG/PPG-27/27 dimethyl siloxane, PEG/PPG-30/10 dimethyl siloxane, PEG/PPG-10/3 oil ether dimethyl siloxane, PEG-8 trisiloxanes, polyglyceryl-3 poly dimethyl siloxy ethyl dimethyl siloxane, PPG-12 butyl ether dimethyl siloxane, siloxanes quaternary ammonium-17, TEA-dimethyl siloxane PEG-7 phosphate, and their mixture.

Emulsifying agent also comprises emulsifying silicone elastomer.Suitable emulsifying silicone elastomer can comprise at least one poly alkyl ether or bound to polyglycerol unit.Also these crosslinked elastomers can be total to modification to comprise alkyl substituent.Suitable formation technical description is in United States Patent (USP) 5,236, in 986,5,412,004,5,837,793 and 5,811,487.The polyoxyalkylene emulsifying silicone elastomer can be used at least one embodiment of the present invention comprises by Shin-Etsu Silicones with trade name KSG-21, KSG-20, KSG-30, KSG-31, KSG-32, KSG-33; KSG-210(dimethyl siloxane/PEG-10/15 cross linked polymer, is scattered in dimethyl siloxane); The silicone cross-linked polymer of KSG-310(PEG-15 lauryl dimethyl), the silicone cross-linked polymer of KSG-320(PEG-15 lauryl dimethyl, be scattered in Fancol ID), the silicone cross-linked polymer of KSG-330(PEG-15 lauryl dimethyl, be scattered in glycerol three (thylhexoic acid) ester), the silicone cross-linked polymer of KSG-340(PEG-10 lauryl dimethyl and the silicone cross-linked polymer of PEG-15 lauryl dimethyl) sell those.Other siloxanes emulsifying elastomer is by Dow Corning ^tMsupply, comprises PEG-12 dimethyl siloxane crosspolymer (DC9010 and 9011).Other suitable silicone emulsifiers of being sold by Dow Corning comprises DC9010 and DC9011.

Bound to polyglycerol emulsifying silicone elastomer is disclosed in PCT/WO2004/024798.This type of elastomer comprises the KSG series of Shin-Etsu, such as KSG-710(dimethyl siloxane/polyglycereol-3 cross linked polymer, be scattered in dimethyl siloxane) or lauryl dimethyl siloxanes/polyglycereol-3 cross linked polymer, be scattered in multi-solvents, in Fancol ID, dimethyl siloxane, glycerol three (thylhexoic acid) ester, with trade name KSG-810, KSG-820, KSG-830 or KSG-840, derive from Shin-Etsu.

Another kind of suitable crosslinked siloxane elastomer emulsifying agent is dimethyl siloxane/PEG-10/15 cross linked polymer, and due to its elastomer main chain, it not only provides excellent aesthetic property, and excellent emulsifiability is provided.The other example of crosslinked organopolysiloxane emulsifying agent includes but not limited to dimethyl siloxane/dimethyl siloxane PEG/PPG15 cross linked polymer; Dimethyl siloxane PEG-10 cross linked polymer; Dimethyl siloxane PEG-10/15 cross linked polymer; Dimethyl siloxane PEG-15 cross linked polymer; Dimethyl siloxane polyglycereol-3 cross linked polymer; Dimethyl siloxane PPG-20 cross linked polymer; Lauryl dimethyl siloxanes PEG-15 cross linked polymer; Lauryl dimethyl siloxanes polyglycereol-3 cross linked polymer; PEG-8 dimethyl siloxane polysorbate-20 cross linked polymer; PEG-10 dimethyl siloxane/vinyl-dimethyl radical siloxane cross linked polymer; The silicone cross-linked polymer of PEG-10 lauryl dimethyl; The silicone cross-linked polymer of PEG-15/ lauryl dimethyl; PEG-15 lauryl poly dimethyl siloxy ethyl cross linked polymer; And their mixture.

Will be appreciated that, silicone elastomer can with the pre-swelling of solvent supply.For preswollen swelling elastomer, for the cited percentage by weight of emulsifying agent used (that is, approximately 0.05% to approximately 20%, approximately 0.1% to approximately 10%, approximately 0.5% to approximately 5%, or approximately 1% to approximately 3% emulsifying agent) be independent elastomer (that is the weight that, does not comprise solvent).

structuring reagent

Except the adjustable acylamino-gellant of pH mentioned above, personal care composition can comprise structuring reagent.Structuring reagent can be used to increase viscosity, thickening, solidifies or provide solid or crystalline texture to personal care composition.The grouping of the compatibility based on dissolubility, dispersibility or phase conventionally of structuring reagent.Example moisture or water-bound reagent comprises polymerizer, natural or paragutta, polysaccharide etc.In one embodiment, by weight of the composition, compositions can comprise one or more structuring reagent of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5%, 1%, 2%, 3%, 5% to approximately 25%, 20%, 10%, 7%, 5%, 4% or 2%.

Polysaccharide and natural gum can be used as water phase thickener.This type of polysaccharide and gummy example comprise natural source material, such as agar, agarose, curdlan, algin, alginic acid, acacia gum, amylopectin, chitin, glucosan, cassia gum (Cassia gum), cellulose gum, gelatin, gellan gum, hyaluronic acid, hydroxyethyl-cellulose, methylcellulose, ethyl cellulose, pectin, sclerotium gum, xanthan gum, pectin, trehalose, gelatin, ammonium alginate, calcium alginate, calcium carrageenan, carnitine, carrageenin, guar gum, guar hydroxypropyltrimonium chloride, hyaluronic acid, HPCH, hydroxypropyl guar gum, karaya, Sargassum, locust bean gum, natto gum, potassium alginate, carrageenin potassium, propylene glycol alginate, Sensor Chip CM 5 sodium, carrageenin sodium, Tragacanth, and their mixture.Suitable polysaccharide comprises alkyl-hydroxyalkylcelluloswith ether, and such as cetyl hydroxyethyl-cellulose, it is the ether of spermol and hydroxyethyl-cellulose.This material is with trade name plus CS is sold by Ashland Aqualon Functional Ingredients.Other available polysaccharide comprises scleroglycan, the straight chain of the glucose unit that it comprises one (1-3) connection, and wherein every 3 unit have the glucose that (1-6) connects, and the example of commercially available acquisition is to derive from M.M.P., the Clearogel of Inc ^tMcS11.

The kind of suitable paradigmatic structure reagent includes but not limited to carboxylic acid polyalcohol, polyacrylamide polymers, sulfonated polymer, high-molecular-weight poly alkyl diol or polyglycereol, their copolymer, their hydrophobically modified derivant and their mixture.

Carboxylic acid polyalcohol comprises carbomer.These polymer are the cross-linking compounds that comprise one or more monomers, described monomer derived is from the acrylic acid of acrylic acid, replacement and acrylic acid salt and the ester of these acrylic acid and replacement, wherein cross-linking agent comprises two or more carbon-to-carbon double bonds, and derived from polyhydric alcohol.Suitable material comprises 900 series (as derive from Noveon, Inc's 945, 940, 950, 954, 980, 951 Hes 981) and ultrez series (as ultrez10 polymer, ultrez20 polymer and ultrez21 polymer).Other suitable carboxylic acid polymerizer comprises C _10-30the copolymer of alkyl acrylate and one or more monomers, described monomer is that acrylic acid, methacrylic acid or their short chain (are C _{1- 4}alcohol) one of ester, wherein cross-linking agent is the allyl ether of sucrose or tetramethylolmethane.These copolymers are called acrylate/C _10-30alkyl acrylate crosspolymer, and with 1342, 1382, PEMULEN ^tMtR-1 and PEMULEN ^tMtR-2 is from Noveon, and Inc is commercially available.

Sulfonated polymer comprises polymer and copolymer and the salt thereof that comprises 2-acrylamide-2-methyl propane sulfonic acid (that is, AMPS or acryloyldimethyl taurine).Exemplary AMPS structural agent comprises sodium acrylate/sodium acryloyldimethyl taurate copolymers, with trade name eG and ePG or 2-(Acryloyloxy)ethanol/sodium acryloyldimethyl taurate copolymers, with trade name nS, fL and i-NS100 is purchased from SeppicCorporation(Fairfield, N.J.).Another kind of suitable sulfonated polymer is polyacrylamide dimethyl sodium taurocholate, with trade name 800 derive from Seppic Corporation(Fairfield, N.J.).Other suitable sulfonated polymer comprises acrylamide/sodium acryloyldimethyl taurate/acrylic copolymer, with trade name Acudyne ^tMsCP is purchased from Rohm and Haas Company, Inc.; Acrylamide/sodium acryloyldimethyl taurate copolymers, with trade name 600 purchased from Seppic; Yu base polyoxyethylene ether-25, ammonium acryloyldime-thyltaurate/mountain methacrylate cross linked polymer, with trade name bLV is purchased from Clariant International Ltd.; Ammonium acryloyldime-thyltaurate/acrylic acid carboxylic ethyl ester cross linked polymer, with trade name tAC is purchased from Clariant International Ltd.; Ammonium acryloyldime-thyltaurate/vinylpyrrolidone copolymer, with trade name aVC is purchased from Clariant International Ltd.; DMAA/sodium acryloyldimethyl taurate cross linked polymer, with trade name SUpolymer G-1 purchased from Toho Chemical Industry Co., Ltd.; Sodium acrylate/acryloyldimethyl taurate/DMAA cross linked polymer, with trade name Sepinov ^tMp88 is purchased from Seppic; And sodium acryloyldimethyl taurate/VP cross linked polymer, with trade name aVS is purchased from Clariant International, Ltd..Additional sulfonated chemical structure agent is described in U.S. Patent Application Publication 2007/0140993 in (regarding as the gellant with the form of the copolymer of acryloyldimethyl taurine or its salt) and 2006/0147396A1 (regarding as " polymer that comprises at least one sulfo group official monomer ").

Acrylamide polymer and copolymer comprise derive from Seppic Corporation(Fairfield, N.J.) 305, it is by the International Cosmetic Ingredient Dictionary and Handbook of Personal Care Product Council, the 13 edition, 2010, called after " polyacrylamide and isoparaffin and laureth-7 ".Other polyacrylamide polymers comprises the acrylamide of acrylamide and replacement and acrylic acid segmented copolymer of acrylic acid and replacement.The example of the commercially available acquisition of these segmented copolymers comprise derive from Lipo Chemicals, Inc.(Patterson, N.J.) sR150H, SS500V, SS500W, SSSA100H.

Poly-alkyl diol or the polyglycereol of high molecular can be used as structuring reagent.Suitable material comprises Polyethylene Glycol (PEG) derivant and polypropylene glycol (PPG) derivant of the degree of polymerization with n.N can be 50 to 200,000.Also suitable is polyglycereol, its glycerol part for repeating, and the scope of the number of the part wherein repeating is from 15 to 200, or about 20-100.The example of suitable polyglycereol comprises that having INCI name is called those of polyglycereol-20, polyglycereol-40 etc.

The example of oil structuring reagent comprises siloxanes and organic group material.The scope of suitable oily structuring reagent is approximately 0.01%, 0.05%, 0.1%, 0.5%, 1%, 2.5%, 5% or 10% to approximately 30%, 25%, 20%, 15%, 10% or 5%.Suitable structured oil phase reagent can be siloxy group, such as silicone elastomer, siloxane glue, siloxane wax, have a linear siloxanes that allows siloxanes to increase the degree of polymerization of oil phase viscosity.The example of siloxane structure reagent includes but not limited to silicone elastomer, siloxane glue and siloxane wax.

Be applicable to silicone elastomer in the present composition comprise by additive reaction-solidify, by make the diorganosiloxane that comprises SiH and there is the organopolysiloxane reaction of end olefinic degree of unsaturation or under the existence of platinum metal catalyst, alpha-omega dienes hydrocarbon reaction forms those.This type of elastomer also can form by other reaction method, such as under the existence of organo-tin compound, via hydroxy-end capped diorganopolysiloxaneand with containing the diorganopolysiloxaneand of SiH or the dehydrogenation reaction condensation-curing organopolysiloxane composition between α ω diene; Or under the existence of organo-tin compound or titanate esters, use condensation reaction between hydroxy-end capped diorganopolysiloxaneand and hydrolyzable organopolysiloxane by condensation-curing organopolysiloxane composition; Peroxide cure organopolysiloxane composition, its heat cure under the existence of organic peroxide catalyst.Can be used for cross-lined organic polyorganosiloxane elastomer in the present invention and be also described in United States Patent (USP) 4,970 for the preparation of their method, in 252,5,760,116 and 5,654,362,6,524,598 and 6,696,049.Because they provide excellent " sensation " to compositions, highly stable in cosmetic formulations, and relatively inexpensive, especially expectation is that silicone elastomer is mixed in compositions of the present invention.

Suitable silicone elastomer can be powder type, or is dispersed or dissolved in solvent, such as volatility or non-volatile siloxane, or the compatible carrier of siloxanes, such as hydrocarbon or ester.The example of silicone elastomer powder comprises vinyl-dimethyl radical siloxane/methylsiloxane silsesquioxane cross linked polymer, as KSP-100, KSP-101, KSP-102, KSP-103, KSP-104, KSP-105, purchased from Shin-Etsu, the hydridization silicone powder that comprises fluoro-alkyl, as KSP-200, purchased from Shin-Etsu, it is fluoro-silicone elastomer, and the hydridization silicone powder that comprises phenyl, such as KSP-300, purchased from Shin-Etsu, the silicone elastomer that it replaces for phenyl; And DC9506, purchased from Dow Corning.

The example that is scattered in the silicone elastomer of the compatible carrier of siloxanes comprises dimethyl siloxane/vinyl-dimethyl radical siloxane cross linked polymer, by a plurality of suppliers, supplied, comprise with trade name DC9040 or DC9041 and being supplied by Dow Corning Corporation, with trade name, SFE839 is supplied by Momentive, or is supplied by Shin-Etsu Silicones with trade name KSG-15,16,18.KSG-15 have INCI title cyclopentasiloxane (with) dimethyl siloxane/vinyl-dimethyl radical siloxane cross linked polymer.KSG-18 have INCI title diphenyl siloxy Silicone DC 556 (with) dimethyl siloxane/phenyl vinyl dimethyl siloxane crosspolymer.Silicone elastomer also can trade mark Gransil purchased from Grant Industries.Other suitable silicone elastomer has chain alkyl substituent group, such as lauryl dimethyl siloxanes/vinyl-dimethyl radical siloxane cross linked polymer, by Shin Etsu, with trade name KSG-31, KSG-32, KSG-41, KSG-42, KSG-43 and KSG-44, supplied.

Silicone gum is another kind of structured oil phase reagent.At 25 ℃, silicone gum has approximately 500,000 conventionally to 100,000,000cst, the viscosity within the scope of approximately 600,000 to 20,000,000, approximately 600,000 to 12,000,000cst.The silicone gum that is used for compositions includes but not limited to those of following general formula, wherein:

R ₁to R ₁₀independently of one another for hydrogen, there is alkyl, aryl or the aralkyl of 1 to 30 carbon atom; And X is H, OH or C1-30 alkyl or vinyl.X, y or z can be zero, and condition is (x+y+z) >=1.

This type of silicone gum can be pure form from a plurality of siloxanes manufacturer, buy, described manufacturer comprises Wacker-Chemie or Dow Corning etc.Silicone gum comprises those that sold with trade name CM3092, Wacker-Belsil1000 or Wacker-Belsil DM3096 by Wacker-Belsil.The silicone gum that wherein X is OH is also known as dimethyl silica alkanol, with trade name 1-1254 fluid, 2-9023 fluid and 2-9026 fluid purchased from Dow Corning Corporation.Silicone gum also can, with solution or dispersion in the compatible carrier of siloxanes, be buied such as the form of volatility or non-volatile siloxane.The example of this type of mixture can HL-88 trade name purchased from Barnet Silicones, there is INCI title dimethyl siloxane.Another example is the mixture of dimethyl silica alkanol and volatility or non-volatile siloxane, with trade name 1401 fluids, 1403 fluids and 1501 fluids purchased from Dow Corning Corporation.

The structured oil phase reagent of another kind of type comprises siloxane wax.Siloxane wax can be known as alkylsiloxane wax, and it is at room temperature semisolid or solid.Term " alkylsiloxane wax " refers to has the polydimethylsiloxane of chain alkyl (such as C16 to 30) from the replacement of semisolid or solid performance to siloxanes that give.The example of this type of siloxane wax comprises stearyl dimethicone, its can trade name Abil Wax9800 purchased from Evonik Goldschmidt GmbH, or with trade name 2503 purchased from Dow Corning.Another example is two-stearyl dimethicone (its with can trade name Gransil A-18 purchased from Gransil Industries), mountain Yu base dimethyl siloxane or mountain Yu oxygen base dimethyl siloxane.

Other suitable viscosifier comprise polyamide and polysiloxanes-polyamide copolymer.Suitable polysiloxanes-polyamide copolymer is disclosed in U.S. Patent Application Publication 2004/0170586.The object lesson of this analog copolymer is for deriving from nylon 611/dimethylsiloxane copolymer of Dow Corning with trade name Dow Corning2-8178.Also suitable is polyamide, such as with trade name Uniclear ^tMwith purchased from Arizona Chemical those, comprise a200V or A2614V(INCI title: ethylenediamine/hydrogenated dimer dilinoleic acid ester copolymer/bis--bis--C14-18 alkylamide); aF1900V and pA1200V(INCI title: Polyamide-3); c75V(INCI title: two-stearyl ethylenediamine/neopentyl glycol/stearyl hydrogenated dimer dilinoleic acid ester copolymer); pE400V(INCI title: polyamide-6); wF1500V(INCI title: polyamide-4); Or Uniclear ^tM100VG(INCI title: ethylenediamine/stearyl dimer dilinoleic acid ester copolymer; Or ethylenediamine/stearyl dimer two tall oil fat acid ester copolymers).

Other structured oil phase reagent comprises one or more natural or synthetic waxs, such as animal, vegetable or mineral wax.In general, this type of wax has approximately 25 ℃ to 125 ℃, and alternatively, the fusing point within the scope of approximately 30 ℃ to approximately 100 ℃.The non-limitative example of suitable wax comprises siloxane wax, fatty acid ester, for example cetyl and/or stearyl, Acacia farnesiana Willd., Cera Flava, ceresin, floral wax, Citrus wax, Brazil wax, Jojoba wax, Japan wax, polyethylene, crystallite, Testa oryzae, lanolin wax, ermine, montan wax, bayberry, ouricury wax, ceresine, palm kernel wax, paraffin, American Avocado Tree wax, Fructus Mali pumilae wax, shellac wax, Salvia japonica Thunb. wax, large wheat husk wax, candelilla wax, Fructus Vitis viniferae wax, their polylalkylene glycol derivatives (for example PEG6-20 Cera Flava or PEG-12 Brazil wax), and any mixture in the aforementioned wax of mentioning.In one embodiment, described wax is Tissuemat E, and alternatively, for having, is less than 120 ℃, or is less than 95 ℃, and or is less than the Tissuemat E of 85 ℃ of fusing points.

The non-limitative example of suitable siloxane wax is disclosed in United States Patent (USP) 5,413, in 781 and 5,725,845, and comprises alkyl methyl polysiloxanes, C10-C60 alkyl-dimethyl radical siloxane and their mixture.Alternatively, described siloxane wax can be C16-C28 alkyl dimethyl siloxane wax.Other suitable siloxane wax includes but not limited to stearic oxygen base dimethicone, mountain Yu oxygen base dimethyl polysiloxane, stearyl dimethicone, cetearyl dimethyl siloxane, cetyl dimethyl siloxane and their mixture.

Other structuring reagent is natural or synthetic montmorillonite mineral, such as Strese Hofmann's hectorite., bentonite and their quaternary ammonium derivative, it is by making mineral react acquisition (as stearyl dimethyl benzyl ammonium bentonite and stearyl dimethyl benzyl ammonium Strese Hofmann's hectorite .) with quaternary ammonium compound.

Other structuring reagent is silicon dioxide, silicate, silylanizing silicon dioxide and their alkali metal or alkaline earth metal derivative.These silicon dioxide and silicate generally exist with granular form, and comprise silicon dioxide, silylanizing silicon dioxide, aluminium-magnesium silicate etc.

optional personal nursing composition

Personal care composition can comprise one or more optional components with the product providing effectively and/or consumer is expected.For example, compositions can comprise other active substance or reagent.For example, suitable optional active substance and reagent can comprise and is selected from following active substance or reagent: osamine, vitamin, control oil preparation, plant sterol, primoline compound, the agent of compacting, anti-wrinkle active substance, anti-atrophy active substance, flavonoid, N-acyl amino acid compound, retinoid, peptide, particulate matter, UV active substance, light stabilizer, the scorching agent of anti-cellulite, desquamation active substance, anti-acne active substance, antioxidant, free radical scavenger, conditioner, antiinflammatory, U.S. black active substance, skin lightening agent, plant extract, anti-microbial active matter, antifungus active substance, antibacterial substance, antiperspirant active, sensory agent, antiseptic, anti-dandruff active, affinity polymer, detersive surfactant, and their combination.Suitable optional components is discussed hereinafter in more detail.

1. osamine

Compositions of the present invention can comprise osamine, and it is also referred to as amino sugar.Can be used for amadori compound in the present invention and can comprise that being described in PCT announces those in WO02/076423 and United States Patent (USP) 6,159,485.In one embodiment, compositions can comprise by one or more osamines of the weighing scale of compositions approximately 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 10%, 7,5% or 2%.

Osamine can be synthetic or natural origin, and the mixture (for example extracting the mixture from natural source or synthetic) that can be used as pure compound or compound is used.For example, glycosamine is present in many shellfishes conventionally, and also can be derived from fungal source.As used herein, " osamine " comprises this type of isomer and tautomer and salt (as HCl salt) thereof, and can be commercially available from Sigma Chemical Co..

The example that can be used for osamine herein comprises glycosamine, N-acetyl glucosamine, mannosamine, N-acetyl group mannosamine, galactosamine, GalNAc, their isomer (for example stereoisomer) and their salt (for example HCl salt).What be preferred for this paper is glycosamine, especially GLUCOSAMINE and N-acetyl glucosamine, especially N-acetyl group-GLUCOSAMINE.

2. vitamin

In one embodiment, by weight of the composition, compositions can comprise one or more vitamin of approximately 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 10%, 7,5% or 2%." vitamin " refers to vitamin, provitamin and their salt, isomer and derivant.The non-limitative example of suitable vitamin comprises: vitamin B compound (comprises B1 compound, B2 compound, B3 compound, B5 compound, such as pantothenylol or " front-B5 ", pantothenic acid, general base; B6 compound, such as pyridoxine, 2-methyl-3-hydroxy-4-formyl-5-hydroxymethylpyridine., pyridoxamine; Carnitine, thiamine, riboflavin); Natural and/or the synthetic analogues of vitamin A compounds and all vitamins A, comprises that retinoid, retinol, acetic acid retinyl ester, VITAMIN A PALMITATE, tretinoin, retinal, propanoic acid retinyl ester, carotenoid (provitamin A) and other have the bioactive compound of vitamin A; Vitamin D compounds; Vitamin K compound; Vitamin E compound or tocopherol, comprise ester and the tocopherol compound of tocopherol sorbate, Tocopherol acetate ester, other tocopherol; Vitamin C compounds, comprises the acid ascorbyl ester of Ascorbate, fatty acid, and ascorbic acid derivates, and for example, ascorbic acid phosphate, as magnesium ascorbyl phosphate and sodium ascorbyl phosphate, ascorbyl glucoside and sorbic acid acid ascorbyl ester; And vitaminF compound, as saturated and/or unsaturated fatty acid.

In certain embodiments, personal care composition comprises vitamin b 3 compound.Vitamin b 3 compound especially can be used for regulation of skin situation, as United States Patent (USP) 5,939, described in 082.In one embodiment, by weight of the composition, compositions can comprise approximately 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 50%, 20%, 10%, 7% or 5% vitamin b 3 compound.

As used herein, " vitamin b 3 compound " refers to the compound with following formula:

Wherein R is-CONH ₂(that is, nicotiamide) ,-COOH(, nicotinic acid) or-CH2OH(, cigarette base alcohol); Its derivant; And aforementioned any salt.

The exemplary derivant of aforementioned vitamin b 3 compound comprises nicotinyl alcohol esters, nicotinic acid N-oxide and the nicotinoyl amine n-oxide of nicotinate (comprising non-vasodilation nicotinate, for example tocopheryl nicotinate, myristyl nicotinate), cigarette base aminoacid, carboxylic acid.

3. control oil preparation

Personal care composition can comprise one or more control oil preparationes for the generation of regulation of skin oil, sebum, or for improving the outward appearance of oily skin.The example of suitable control oil preparation comprises salicylic acid, dehydroactic acid, benzoyl peroxide, vitamin b 3 compound, their isomer, ester, salt and derivant and their mixture.Dehydroactic acid comprise there is the material of following formula or the acceptable salt of dermatological, their derivant or tautomer:

The technical name of dehydroactic acid is 3-acetyl group-6-methyl-2H-pyrans-2,4 (3H)-diketone, and can be commercially available from Lonza.

The acceptable salt of dermatological comprises alkali metal salt, as sodium salt and potassium salt; Alkali salt, as calcium salt and magnesium salt; Nontoxic heavy metallic salt; Ammonium salt; And trialkyl ammonium salts, as leptodactyline and triethyl ammonium salt.In a particular embodiment, can use sodium, potassium and the ammonium salt of dehydroactic acid.Dehydro sodium acetate with Tristat SDHA purchased from Tri-K Industries, Inc.The derivant of dehydroactic acid includes but not limited to wherein CH ₃group any compound single or that replaced by amide, ester, amino, alkyl and alcohol ester in combination.The tautomer of dehydroactic acid is the more easily isomer of the dehydroactic acid of conversion each other, and their common balances are existed.Therefore, the tautomer of dehydroactic acid can be described to have chemical formula C ₈h ₈o ₄and generally there is above-mentioned formula.

Other control oil preparation comprises the material that can absorb oil and sebum.Suitable oil absorption material comprises that starch, calcium silicates, polyethylene, nylon, boron nitride, Muscovitum, clay (such as bentonite, montorillonite clay and Kaolin), zeolite, cyclodextrin, pyrogenic silica, synthesis of clay are such as polymer powder, comprises natural, synthetic and semisynthetic cellulose, fluorocarbon resin, polypropylene, the starch of cellulose acetate modification, particulate crosslinked hydrophobic acrylic acid's ester or methacrylate copolymer and their mixture.

In one embodiment, by weight of the composition, personal care composition can comprise one or more control oil preparationes of approximately 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 25%, 20%, 10%, 7%, 5% or 3%.

4. plant sterol

Personal care composition can comprise plant sterol.For example, one or more plant sterols can be selected from cupreol, campesterol, campesterol, Δ 5-avenasterol, lupanol, hitodesterol, stigmasterol, their derivant, analog and their combination.In certain embodiments, plant sterol is selected from cupreol, campesterol, campesterol, stigmasterol, their derivant and their combination.More preferably, plant sterol is stigmasterol.

Plant sterol can be synthetic or natural origin, and can be used as substantially pure compound or the mixture of compound (for example extracting from natural source) is used.Plant sterol is generally present in the not saponification part of vegetable oil & fat, and can free sterol, acetyl derivatives, sterol ester, ethoxylation or glycosides derivatives obtain.More preferably, plant sterol is free sterol.As used herein, " plant sterol " comprises this type of isomer and tautomer, and commercially available from Aldrich Chemical Company, Sigma Chemical Company and Cognis.

In one embodiment, by weight of the composition, compositions can comprise one or more plant sterols of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 25%, 20%, 10%, 7%, 5% or 3%.

5. primoline compound

Personal care composition can comprise primoline compound, its salt and derivant.As used herein, " primoline compound " refers to the compound with following formula:

R wherein ¹and R ²be optional, or be organic acid (such as sulfonic acid etc.).

In one embodiment, by weight of the composition, compositions can comprise one or more primoline compounds of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 25%, 20%, 10%, 7%, 5% or 3%.

As used herein, primoline derivant comprises any isomer and the tautomer of primoline compound, includes but not limited to organic acid and mineral acid, such as sulfonic acid, carboxylic acid etc.In the embodiment of a selection, primoline compound comprises the own oxygen phenylate of dihydroxy ethyl sulfonic acid, with hP100 is commercially available from Laboratoires Serobiologiques.

6. the agent of compacting

Personal care composition can comprise the agent of compacting.The agent of compacting is for can be at collenchyme, and conventionally on skin, has the compound of the effect of compacting.The suitable agent of compacting can be selected from plant or animal proteinum and their hydrolyzate, such as Semen Maydis, rye (Secale cereale L.), Semen Tritici aestivi, Semen Fagopyri Esculenti, Semen Sesami, Spezia wheat, Semen Pisi sativi, Kidney bean, Lens culinaris Medic., Semen sojae atricolor and lupin; The polysaccharide of natural origin comprises (i) polysaccharide, such as with especially derived from the form of the starch of rice, Semen Maydis, Rhizoma Solani tuber osi, Maninot esculenta crantz., Semen Pisi sativi, Semen Tritici aestivi, Herba bromi japonici etc., or with the form of carrageenin, alginate esters, agar, gellan gum, cellulosic polymer and pectin, advantageously with the aqueous dispersion of microgel particle, and (ii) by lac resin, mountain, reached the latex of glue, dammar gum, Canarium luzonicum Elemi, Resin copal, cellulosic cpd and their compositions of mixtures; The silicate mixing comprises phyllosilicate, and is in particular LAPONITE; The colloidal particles of inorganic filler, such as silica/alumina colloidal particles, such as with trade name those that sold by W.R.Grace & Co.; Synthetic polymer, such as polyurethane rubber latex or acrylic acid/siloxane latex, be in particular and be described in those in U.S. Patent Application Publication 2002/0131948, comprise the polydimethylsiloxane (with trade name VS80, VS70 and L021 purchased from 3M) of polydimethylsiloxane, rosickyite base (polyisobutyl methacrylate) and rosickyite base (polymethylacrylic acid) grafting of rosickyite base (polymethyl acrylate), rosickyite base (polymethyl methacrylate) and rosickyite base (polymethylacrylic acid) grafting; And their mixture.

By weight of the composition, personal care composition can comprise one or more agent of compacting of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 30%, 25%, 20%, 10%, 7%, 5% or 3%.

7. anti-wrinkle active substance/anti-atrophy active substance

Compositions of the present invention can comprise one or more anti-wrinkle active substances or anti-atrophy active substance.Exemplary anti-wrinkle/anti-atrophy the active substance being applicable in compositions of the present invention comprises two alkanoyl hydroxyproline compounds, hydroxy acid (as glycolic, lactic acid, lactobionic acid), keto acid (as acetone acid), phytic acid, lysophosphatidic acid, stilbene, cinnamate, resveratrol, kinetins, zeatin, dimethylamino ethanol, derives from the peptide (as soybean peptide) of natural source and the salt of saccharic acid (as gluconic acid Mn, gluconic acid Zn).In one embodiment, by weight of the composition, compositions can comprise one or more anti-wrinkles/anti-atrophy compound of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 30%, 25%, 20%, 10%, 7%, 5% or 3%.

Suitable two alkanoyl hydroxyproline compounds of the present invention can comprise corresponding to those of following chemical formula:

R wherein ¹for H, X, C ₁-C ₂₀the alkyl of straight chain or branching,

X is metal (Na, K, Li, Mg, Ca) or amine (DEA, TEA);

R ²for C ₁-C ₂₀the alkyl of straight chain or branching;

R ³for C ₁-C ₂₀the alkyl of straight chain or branching.

Suitable derivant includes but not limited to ester, and for example fatty acid ester, includes but not limited to three palmityl hydroxyprolines and two palmityl acetyl group hydroxyprolines.Especially available compound is dipalmitoyl hydroxyproline.As used herein, dipalmitoyl hydroxyproline comprises this type of any isomer and tautomer, and with trade name Sepilift from Seppic, Inc. is commercially available.The other discussion of dipalmitoyl hydroxyproline appears at PCT and announces in WO93/23028.Preferably, the triethanolamine salt that dipalmitoyl hydroxyproline is dipalmitoyl hydroxyproline, as United States Patent (USP) 7,285, institute is discussed in 570.

8. flavonoid

Compositions of the present invention can comprise flavonoids.Flavonoid is disclosed in United States Patent (USP) 5,686 widely, in 082 and 5,686,367.The example that is particularly useful for the flavonoid in the present invention is one or more flavone, one or more isoflavone, one or more coumarins, one or more chromones, one or more dicoumarols, one or more benzodihydropyrones, one or more benzodihydropyran alcohol, their isomer (as cis/trans isomer) and their mixture.

Exemplary flavonoid comprises flavone and isoflavone, be in particular daidzein (7,4'-dihydroxy isoflavone), genistein (5,7,4 '-trihydroxy-isoflavone), equol (7,4 '-dihydroxy isoflavone), this type of mixture (as red Herba Trifolii Pratentis) and their mixture of Biochanin A, soybean isoflavone (extracting the mixture from Semen sojae atricolor) and other plant source.Flavanone preferably also, such as hesperetin, hesperidin and their mixture.The flavonoids can be used for herein can be commercially available from a plurality of sources, Indofine Chemical Company for example, Inc., Steraloids, Inc. and Aldrich Chemical Company, Inc..

In one embodiment, by weight of the composition, compositions can comprise one or more flavonoidss of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 30%, 25%, 20%, 10%, 7%, 5% or 3%.

9.N-acyl amino acid compound

Topical composition of the present invention can comprise one or more N-acyl amino acid compounds.Aminoacid can be any in known amino acid in this area.N-acyl amino acid compound of the present invention can meet following formula:

Wherein R can be the combination of hydrogen, alkyl (replacement or unsubstituted, branching or straight chain) or alkyl and aryl.The list of amino acid whose possibility side chain as known in the art is described in " Biochemistry " of the Stryer being published by W.H.Freeman and Company for 1981.R ¹can be saturated or undersaturated, straight chain or branching, replacement or unsubstituted C ₁-C ₃₀alkyl; Replace or unsubstituted aryl; Or their mixture.

N-acyl amino acid compound can be selected from N-acylphenylalanines, N-acyl group tyrosine, their isomer, their salt and their derivant.Aminoacid can be D or L isomer or their mixture.N-acylphenylalanines meets following formula:

R wherein ¹can be saturated or undersaturated, straight chain or branching, replacement or unsubstituted C ₁-C ₃₀alkyl; Replace or unsubstituted aromatics perfume base group or their mixture.

N-acyl group tyrosine meets following formula:

R wherein ¹can be saturated or undersaturated, straight chain or branching, replacement or unsubstituted C ₁-C ₃₀alkyl; Replace or unsubstituted aromatics perfume base group or their mixture.

What especially can be used as local colour of skin homogenize cosmetic agent is N-endecatylene acyl-L-Phe.This reagent belongs to the N-acylphenylalanines derivant classification of broad sense, and wherein its acyl group is C11 monounsaturated fatty acid part, and aminoacid is the L-isomer of phenylalanine.N-endecatylene acyl-L-Phe meets following formula:

As used herein, N-endecatylene acyl-L-Phe can trade name commercially available from SEPPIC.

In one embodiment, by weight of the composition, compositions can comprise one or more N-acylamino acids of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 30%, 25%, 20%, 10%, 7%, 5% or 3%.

10. retinoid

Personal care composition can comprise one or more retinoids.In one embodiment, by weight of the composition, compositions can comprise one or more retinoids of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 30%, 25%, 20%, 10%, 7%, 5% or 3%.Best working concentration in compositions will depend on selected concrete kind visual pigment, because their effect can be significantly different.

As used herein, " retinoid " comprises, has the natural and/or synthetic analogues of the bioactive all vitamins A of vitamin A in skin or the compound of similar retinol, and the geometric isomer of these compounds and stereoisomer.Retinoid is optional from retinol, retinol ester (the C2-C22 Arrcostab as retinol, comprises retinyl palmitate, retinyl acetate, Vitamin A propionate), retinal and/or tretinoin (comprising all-trans retinoic acid and/or Accutane) or their mixture.Suitable retinoid is described in United States Patent (USP) 4,677,120,4,885,311,5,049,584,5,124,356 and reissue 34,075 in.Other suitable retinoid can comprise tocopherol retinoic acid ester [Renascin of tretinoin (trans-or cis-), adapalene (6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid } and tazarotene (6-[2-(4,4-dimethyl thiochroman-6-yl) acetenyl] ethyl nicotinate).Suitable retinoid comprises retinol, retinyl palmitate, retinyl acetate, Vitamin A propionate, retinal and their combination.In the embodiment selecting, the amount that Vitamin A propionate can approximately 0.1% to approximately 0.3% is used.

11. peptides

Personal care composition can comprise peptide.Suitable peptide can include but not limited to dipeptides, tripeptides, tetrapeptide, pentapeptide and six peptides and their derivant.In one embodiment, compositions comprises by weight approximately 1 * 10 ^-7% is to approximately 20%, approximately 1 * 10 ^-6% is to approximately 10%, or approximately 1 * 10 ^-5% is approximately 5% peptide extremely.In one embodiment, by weight of the composition, compositions can comprise one or more peptides of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 25%, 20%, 10%, 7%, 5%, 3%.

As used herein, " peptide " refer to comprise ten or still less amino acid whose peptide and their derivant, isomer and with other material for example, as the complex of metal ion (, copper, zinc, manganese, magnesium etc.).Peptide refer to naturally occurring and synthetic peptide the two.Also can be used for of the present invention be naturally occurring and commercially available acquisition containing peptide combinations.Peptide can comprise at least one basic amino acid (as histidine, lysine, arginine).For example, suitable peptide is lipophilic derivant and the aforesaid metal composite (as the copper composition of tripeptides HIS-GLY-glycine (also referred to as glycine)) of dipeptides carnosine (Beta-alanine-histidine), tripeptides Gly-His-Lys, tripeptides HIS-GLY-glycine, tripeptides Gly-Gly-histidine, tripeptides Gly-His-glycine, tetrapeptide Gly-Gln-Pro-Arg, pentapeptide K-T-T-K-S, peptide.Other suitable peptide comprises PEPC K(arginine-lysine-arginine); PEPC K+(acetyl-arginine-lysine-arginine-NH2); With peptide E, arginine-Vitro By Serine/arginine-lysine.The compositions that comprises the commercially available acquisition of tripeptide derivative is Biopeptide (deriving from Sederma, France), palmityl-Gly-His-Lys that it comprises 100ppm, and commercially available acquisition.The compositions of the commercially available acquisition that comprises pentapeptide derivative is (deriving from Sederma, France), the pal-KTTKS that it comprises 100ppm.Suitable peptide is the molecule with two peptidyls of threonine end amino acid such as palmityl-lysine-threonine, described in U.S. Patent Application Publication 2007/0020220A1.

For peptide derivant herein, comprise lipophilic derivant, such as palmityl derivant.In one embodiment, peptide is selected from pal-KTTKS, palmityl-Gly-His-Lys, their derivant and their combination.

12. particulate matters

Compositions of the present invention can comprise one or more particulate matters.The non-limitative example that can be used for the particulate matter in the present invention comprises painted and uncoloured pigment, coated interference pigment, inorganic powder, organic dust, composite powder, fluorescent whitening agent granule and their combination.These granules can be lamellar, spherical, elongated or needle-like or erose, surface-coated for example or uncoated, porous or atresia, electrically charged or uncharged, and can be used as powder or be added in present composition as predispersion.In one embodiment, by weight of the composition, compositions can comprise one or more granules of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5%, 1% or 2% to approximately 50%, 25%, 20%, 10%, 7%, 5% or 3%.For pigment used in compositions, coloring agent or filler powder, there is no concrete restriction.

For particulate matter herein, can include but not limited to bismuth oxychloride, sericite, Muscovitum, Muscovitum by barium sulfate or other mass treatment, zeolite, Kaolin, silicon dioxide, boron nitride, lauroyl lysine, nylon, polyethylene, Pulvis Talci, styrene, polypropylene, polystyrene, ethylene/acrylic acid copolymer, polyurethane, aluminium oxide, silicone resin, barium sulfate, calcium carbonate, cellulose acetate, PTFE, polymethyl methacrylate, starch, the starch of modification is such as aluminum starch succinic acid octene ester, silk, glass, and their mixture.The suitable commercial example of granule includes but not limited to be selected from the polymer beads of poly methyl silsesquioxane resin microsphere, such as comprising with trade name the material of being sold by Momentive Performance Materials Inc., the microsphere of polymethyl methacrylate, as the Micropearl M305 of SEPPIC, the spheroidal particle of crosslinked polydimethylsiloxane, especially such as by Dow Corning, with Dow Corning9506Cosmetic Power, sold those, polyamide, and the spheroidal particle of nylon 12 more specifically, such as Atochem's 2002 series, polystyrene microsphere, such as for example with trade name those that sold by Dyno Particles, ethylene acrylate copolymer, with trade name, EA209 is sold by Kobo, and PTFE, polypropylene, aluminum starch succinic acid octene ester, such as with trade name those that sold by AkzoNobel, polyethylene microsphere, such as with trade name fN510-00 by Equistar and with trade name Micropoly by Presperse, those that Inc. sells, silicone resin, poly methyl silsesquioxane siloxane polymer and their mixture.Suitable particulate matter comprises the spherical powder with approximately 0.1 to approximately 75 micron or approximately 0.2 to approximately 30 micron average primary particle sizes.

Other suitable particulate matter comprises coated interference pigment.Object for this description, coated interference pigment is defined as the lamelliform stratification granule of two or more controllable thickness layers with different refractivity, it produces feature reflection colour by common two kinds but the interference of multiple luminous reflectance sometimes, thereby forms the layer of different laminate granulars.The common examples of coated interference pigment is the Muscovitum of TiO2, Fe2O3, silicon dioxide, stannum oxide and/or Cr2O3 rete with about 50-300nm.This type of pigment is generally pearling agent.Since for example, between the transparency of granules of pigments and mica sheet and () coating of titanium dioxide greatest differences of refractive index, pearlescent pigment reflection, refraction and transillumination.Available coated interference pigment can be commercially available from a lot of suppliers, for example Rona(Timiron ^tMand Dichrona ^tM), Presperse(Flonac ^tM), Englehard(Duochrome ^tM), Kobo(KTZ Interfine and KTZ Interval), BASF(Reflecks ^tM) and Eckart(Prestige series).Suitable coated interference pigment can have little granularity, and wherein the average diameter of each granule is less than approximately 75 microns on length direction, or is less than approximately 50 microns.

Other particulate matter comprises can provide to personal care composition the pigment of color.Suitable pigment comprises inorganic pigment, organic pigment and their combination.The example of this type of available inorganic pigment comprises ferrum oxide, ammonium ferrocyanide ferrum, manganese violet, ultramarine blue and chromium oxide.Organic pigment can comprise natural coloring agent and synthetic monomer coloring agent and polymeric colorant.An example is phthalocyanine blue and phthalocyanine green pigment.Also available is color lake, is mainly FD & C or D & C color lake and their blend.Also available is solubility or insoluble dyes and other coloring agent of sealing.Can be used for the inorganic Chinese white in the present invention or coloring pigment, can be not commercially available from a plurality of sources as TiO2, ZnO or ZrO2.An example of suitable particulate matter comprises the material (TRONOX TiO2 series, SAT-T CR837, rutile TiO2) purchased from U.S.Cosmetics.Suitable pigment comprises the electrically charged dispersion of titanium dioxide, as United States Patent (USP) 5,997, disclosed in 887.

Painted or uncoloured pigment can have about 10nm, 15nm or 20nm to approximately 100,000nm, 5, the main particle mean size of 000nm or 1000nm.The mixture with varigrained identical or different pigment also can be used for herein (as having the TiO of about 100nm to about 400nm primary particle sizes ₂with there is about 10nm to the TiO of about 50nm primary particle sizes ₂in conjunction with).

Particulate matter can be by surface treatment to provide additional stability and/or the simplification of preparation.The non-limitative example of suitable coating material comprises siloxanes, lecithin, aminoacid, metallic soap, polyethylene and collagen.These surface conditioning agents can be hydrophobic or hydrophilic.Especially available hydrophobicity pigment inorganic agent comprises polysiloxanes inorganic agent, as is disclosed in United States Patent (USP) 5,143, those in 722.

13.UV active substance

The compositions of this theme invention optionally comprises UV active substance.As used herein, " UV active substance " comprise sunscreen and physical sunscreen frost the two.Suitable UV active substance can be organic or inorganic.Suitable UV active substance is listed in the International Cosmetic Ingredient Dictionary and Handbook the 13 edition of Personal Care Product Council, and 2010, in " Sunscreen Agents " functional category.

Suitable UV active substance comprises dibenzoyl methane derivant; comprise 2-methyldiphenyl formoxyl methane, 4-methyldiphenyl formoxyl methane, 4-isopropyl diphenyl formoxyl methane, the 4-tert-butyl group-dibenzoyl methane, 2; 4-dimethyl dibenzoyl methane, 2; 5-dimethyl dibenzoyl methane, 4; 4'-diisopropyl dibenzoyl methane, 4; 4'-dimethoxy dibenzoyl methane, the 4-tert-butyl group-4'-methoxy dibenzoyl methylmethane (that is, PAROSOL 1789 or avobenzone) (with 1789 is commercially available from DSM), 2-methyl-5-isopropyl-4'-methoxy dibenzoyl methylmethane, the 2-methyl-5-tert-butyl group-4'-methoxy dibenzoyl methylmethane, 2; 4-dimethyl-4'-methoxy dibenzoyl methylmethane and 2, the 6-dimethyl-4-tert-butyl group-4'-methoxy dibenzoyl methylmethane.Other suitable UV active substance comprises 2-ethylhexylpmethoxycinnamate, with mCX is commercially available from DSM), ESCALOL 567, BP-3 (, Neo-Heliopan BB), octyldimethyl para-amino benzoic acid, two times of acyl trioleates, 2, 2-dihydroxy-4-methoxy benzophenone, 4-(two (hydroxypropyl) benzocaine, 2-cyano group-3, 3-diphenylacrylate-2-Octyl Nitrite, salicylic acid-2-Octyl Nitrite, para-amino benzoic acid glyceride, salicylic acid-3, 3, 5-3-methyl cyclohexanol ester, methyl 2-aminobenzoate, ESCAROL 507 or Aminobenzoate, ESCAROL 507-2-Octyl Nitrite, 2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID, 2-(to dimethylaminophenyl)-5-sulfonic acid benzo the mixture of azoles acid, octocrylene, zinc oxide, titanium dioxide and these compounds.

Can be used for UV active substance especially suitable in compositions of the present invention is 2-ethylhexylpmethoxycinnamate, the 4-tert-butyl group-4'-methoxy dibenzoyl methylmethane, 2-hydroxyl-4-methoxybenzene benzophenone, 2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID, octocrylene, zinc oxide, titanium dioxide and their mixture.

Other suitable UV active substance comprise 4 methyl benzylidene camphor (with 5000 from DSM commercially available or Eusolex6300, derive from Merck), Bisoctrizole (that is, and two Octrizoles, with m is commercially available from BASF), two-ethylhexyl oxygen base phenol methoxyphenol triazine (that is, and two ethyl hexyl oxy phenol anisyl triazines, with s is commercially available from BASF), (that is, Bisdisulizole disodium, with Neo for Neo Heliopan AP aP is commercially available from Symrise), Uvinul T 150 (with t150 is commercially available from BASF), Ethylhexysalicylate (being sold by L'Oreal with Mexoryl XL), dihydroxy dimethoxy disulfo benzophenone sodium (that is, and Benzophenone 9, dS49 is commercially available from BASF), diethylamino (2-hydroxybenzoyl) hexyl-benzoate (with a Plus is commercially available from BASF), Uvasorb HEB (that is, and Iscotrizinol, with hEB is commercially available from 3V Sigma), Dimethicodiethylbenzalmalonate (that is, with sLX is commercially available from DSM) and iso-amyl p-methoxycinnamate (that is, A meter Luo ester, with Neo e1000 is commercially available from Symrise).

14. light stabilizers

Suitable light stabilizer is alpha-cyano diphenylacrylate ester, as United States Patent (USP) 7,713, disclosed in 519.Alpha-cyano diphenylacrylate ester can have following general formula:

Wherein R1 and R2 are the C1-30 alkoxyl of straight or branched independently of one another; The R1 of any non-alkoxyl or R2 group are hydrogen; And the C1-30 alkyl that R3 is straight or branched.

Alternatively, R1 and R2 are C1-8 alkoxyl independently, and R1 or R2 are methoxyl group independently of one another, and the R1 of any non-methoxyl group or R2 are hydrogen; And the C2-20 alkyl that R3 is straight or branched.

Suitable alpha-cyano diphenylacrylate ester is the vertical woods of ethylhexyl methoxyl group or 2-cyano group-3-(4-methoxyphenyl)-3-phenylacrylic acid-2-Octyl Nitrite, and wherein R1 is methoxyl group, and R2 is hydrogen, and R3 is 2-ethylhexyl.This material is with trade name s1 is purchased from Hallstar Company.

Another kind of suitable light stabilizer comprises diester or the polyester of naphthalene dicarboxylic acids, as United States Patent (USP) 5,993, disclosed in 789,6,113,931,6,126,925 and 6,284,916.Suitable diester or the polyester of naphthalene dicarboxylic acids can have following formula:

Or

Each R wherein ¹independently for to there is the alkyl of 1 to 22 carbon atom, or there is formula HO-R ²the glycol of-OH, or there is formula HO-R ³-(O-R ²-) _mthe polyglycols of-OH, and identical or different R wherein ²and R ³respectively do for oneself and have 1 to 6 straight chain of carbon atom or the alkylidene of branching, wherein m and n respectively do for oneself 1 to approximately 100,1 to approximately 10, or 2 to approximately 7.The suitable diester of naphthalene dicarboxylic acids is NDA ethylhexyl, with tQ is purchased from Symrise.

Another kind of suitable light stabilizer is 4-hydroxyl toluenyl malonic ester derivant or 4-hydroxycinnamic acid ester derivant.Suitable material can have following formula:

Wherein A, for absorbing the chromophore of UV-radiation, comprises a divalent group or two univalent perssads, and wherein at least one group has carbonyl (C=O) functional group; R ' is the C of hydrogen, straight chain or branching ₁-C ₈the C of alkyl or straight chain or branching ₁-C ₈alkoxyl; And R " be the C of straight chain or branching ₁-C ₈alkyl.Exemplary compound comprises alpha-cyano-3, 5-dimethoxy-4 '-hydroxycinnamic acid ethyl ester, α-acetyl group-3, 5-dimethoxy-4 '-hydroxycinnamic acid ethyl ester, α-acetyl group-3, 5-dimethoxy-4 '-hydroxycinnamic acid isopropyl ester, α-acetyl group-3, 5-dimethoxy-4 '-hydroxycinnamic acid isopentyl ester, α-acetyl group-3, 5-dimethoxy-4 '-hydroxycinnamic acid-2-Octyl Nitrite, 3, 5-dimethoxy-4 '-hydroxyl benzal malonic acid diethylester, 3, 5-dimethoxy-4 '-hydroxyl benzal malonic acid two-(2-ethylhexyl) ester, 3, 5-dimethoxy-4 '-hydroxyl benzal malonic acid diisoamyl ester, 3, the two dodecane esters of 5-dimethoxy-4 '-hydroxyl benzal malonic acid, 3, 5-dimethoxy-4 '-hydroxyl benzal malonic acid two palmityl esters and 3, 5-dimethoxy-4 '-hydroxyl benzal malonic acid two-isopropyl ester.Especially suitable compound is Aden's perfume base malonic acid ethylhexyl (INCI title), with trade name sT is purchased from EMD Chemicals, and Inc., has following formula:

Additional suitable 4-hydroxyl toluenyl malonic ester derivant or 4-hydroxycinnamic acid ester derivant are disclosed in United States Patent (USP) 7,357,919 and U.S. Patent Application Publication 2003/0108492A1 and US2003/0157035A in.

Another kind of suitable light stabilizer is 2-Pyrrolidone-4-carboxyl esterification compound.Suitable 2-Pyrrolidone-4-carboxyl esterification compound can have following formula:

R wherein ¹c for straight chain or branching ₁-C ₂₀alkyl, and R ²c for straight chain or branching ₁-C ₂₀alkyl, it can comprise C ₅-C ₆ring, phenyl, benzyl or phenethyl.For R ¹and R ²exemplary group comprise methyl, ethyl, n-pro-pyl, isopropyl, normal-butyl, isobutyl group, the tert-butyl group, n-octyl, 2-ethylhexyl, dodecyl, cetyl, cyclohexyl and methylcyclohexyl.The object lesson of 2-Pyrrolidone-4-carboxyl esterification compound is provided in U.S. Patent Application Publication 2010/0183529.

Other suitable light stabilizer comprises:

By the s-triazine that comprises silicon of two Aminobenzoates or the replacement of aminobenzoyl amine groups, described in U.S. Patent Application Publication 2008/0145324;

Fluorene derivative, described in U.S. Patent Application Publication 2004/00579912,2004/00579914,200/00579916 and 2004/062726;

Piperidines alkoxide, described in U.S. Patent Application Publication 2005/0220727, comprises three (tetramethyl hydroxy piperidine alcohol) citrate, with trade name q is sold by Ciba; With

Arylalkyl amide and ester, described in U.S. Patent Application Publication 2008/0019930.

Other suitable light stabilizer is listed in the International Cosmetic Ingredient Dictionary and Handbook of Personal Care Product Council, the 13 edition, in " Light Stabilizers " functional category in 2010.

In one embodiment, by weight of the composition, compositions can comprise one or more suitable light stabilizers of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 30%, 25%, 20%, 10%, 7% or 5%.In certain embodiments, personal care composition can comprise at least one light stabilizer and at least one UV active substance.In a particular embodiment, UV active substance is dibenzoyl methane derivant.In a specific embodiment, UV active substance is 4,4'-tert-butyl group methoxy dibenzoyl base-methane (that is, avobenzone).

the scorching agent of 15. anti-cellulites

Compositions of the present invention also can comprise the scorching agent of anti-cellulite.Suitable reagent can include but not limited to Xanthine compounds (as caffeine, theophylline, theobromine, theobromine, aminophylline, chloroethyl theophylline, diprophylline, etamiphylline, brontyl etc.); The extract of tea, coffee, Paullina Cupana, mate tea, Cola (cola); Climb extract, Flos Tagetis Erectae (Flos Inulae), Salvia japonica Thunb. (spending Salvia japonica Thunb. in vain), the Radix Ginseng of Caulis Hederae Sinensis (Caulis Hederae Sinensis), arnica tincture (arnica montana), Herba Rosmarini Officinalis (Herba Rosmarini Officinalis), the extract of extract, butchers broom (butchers broom), Ramulus et Folium Spiraeae Salicifolia (revolving fruit mosquito grass seed), Radix Orthosiphonis Wulfenioidis (Radix Orthosiphonis Wulfenioidis), birch (birch), umbrella tree and the A Ganshu of Herba Hyperici perforati (Radix Hyperici Monogyni (Herba Hyperici Monogyni)); Semen Ginkgo, Herba Equiseti Arvinsis, Aesculus chinensis Bunge, Rhizoma Atractylodis, Flos Matricariae chamomillae, Rhizoma Dioscoreae plant are rich in the extract of diosgenin or pure diosgenin or hecogenin and their compound, Marrubium nigrum, Fructus Sapindi Mukouossi, Rhizoma Drynariae, Terminalia catappa, Radix Solani Torvi winter, mountain Corchorus olitorius L., Antirobia, bigarabe (Citrus aurantium Linn.); And the extract of cacao shell (cocoa), such as with trade name by Solabia, sold.

In one embodiment, by weight of the composition, personal care composition can comprise approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 30%, 25%, 20%, 10%, 7%, 5% or 3% the scorching agent of one or more anti-cellulites.

16. desquamation active substances

Desquamation active substance can be added in compositions of the present invention.In one embodiment, by weight of the composition, compositions can comprise one or more desquamation active substances of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 30%, 25%, 20%, 10%, 7%, 5% or 3%.

Suitable desquamation active substance comprises beta-hydroxy acid, such as salicylic acid and derivant thereof, (comprise 5-(positive caprylyl) salicylic acid, also referred to as decoyl salicylic acid) and 'alpha '-hydroxy acids, such as glycolic, citric acid, lactic acid, tartaric acid, malic acid or mandelic acid; 8-hexadecene-l, 16-dicarboxylic acids or 9-octadecene diacid; Urea; Gentisic acid; Few fucose; Cinnamic acid; Chinese scholar tree extract; And resveratrol.

Other suitable desquamation active substance comprises the compound that acts on enzyme, glycosidase, horny layer Chymotrypsin type enzyme (SCCE) or other protease (trypsin, similar chymase) that relate to desquamation or degraded corneodesmosome.Suitable material comprises sulfamic acid compound, such as 4-(2-ethoxy) piperazine-l-propane sulfonic acid (HEPES); 2-oxo Thiazolidine-4-carboxylic acid (the third cysteine) and compound thereof; The compound of glycine type a-amino acid (described in U.S. Patent Application Publication 2002/0041889, and MDGA sodium, with trade name m is sold by BASF); Mel and sugar compounds, such as O-caprylyl-6-D-maltose and N-acetyl glucosamine.

Desquamation system comprises salicylic acid and a zwitterionic surfactant, as United States Patent (USP) 5,652, described in 228.Another kind of desquamation system comprises sulfhydryl compound and zwitterionic surfactant, as United States Patent (USP) 5,681, described in 852.

17. anti-acne active substances

Compositions of the present invention can comprise one or more anti-acne active substances.Suitable anti-acne active substance includes but not limited to that resorcinol, sulfur, salicylic acid, retinoid are such as tretinoin and derivant, sulfur-containing amino acid and their derivant and salt (as N-acetyl derivative, such as ACETYLCYSTEINE) and thioctic acid.Other suitable anti-acne active substance can be selected from (i) antibiotic and antibacterial, such as benzoyl peroxide, Octopirox, tetracycline, 2,4, the chloro-2'-dihydroxy diphenyl ether of 4' tri-, 3,4,4'-trichlorine diphenyl urea, Azelaic Acid and their derivant, phenyl phenol, phenoxypropanol, phenoxy group isopropyl alcohol, ethyl acetate, clindamycin and meclocycline; (ii) the salt of sebum (sebostats), such as flavonoid; (iii) bile salts, such as scymnol sulfate and derivant, dexycholate and cholate.The suitable other example of anti-acne active substance is described in United States Patent (USP) 5,607, in 980.

In one embodiment, by weight of the composition, compositions can comprise one or more anti-acne compounds of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 30%, 25%, 20%, 10%, 7%, 5% or 3%.

18. antioxidants/free radical scavenger

Compositions of the present invention can comprise antioxidant/free radical scavenger.In one embodiment, by weight of the composition, compositions can comprise one or more antioxidant/free radical scavengers of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 30%, 25%, 20%, 10%, 7%, 5% or 3%.

Suitable antioxidant is listed in the International Cosmetic Ingredient Dictionary and Handbook the 13 edition of Personal Care Product Council, in " Antioxidants " functional category in 2010.

Suitable antioxidant comprises Yoshinox BHT (BHT) and butylated hydroxyanisol (BHA).BHT can be described by following general formula:

Wherein X is OH or SH;

Y is selected from H, OH, OR ₅, COOR ₅, alkyl, cycloalkyl, assorted alkyl, Heterocyclylalkyl, aromatics, heteroaromatic, carboxamido, sulfonamido, carbamic acid root, urea and trialkylsilkl;

R ₁, R ₂, R ₃, R ₄be selected from alkyl, cycloalkyl, assorted alkyl, Heterocyclylalkyl, aromatics, heteroaromatic, OR ₅, carboxamido, sulfonamido, formoxyl, acyl group, carboxyl, carboxylate radical, carbamic acid root, urea, trialkylsilkl, hydroxyl and hydrogen;

R ₅be selected from alkyl, cycloalkyl, assorted alkyl, Heterocyclylalkyl, aromatics, heteroaromatic, trialkylsilkl, acyl group and hydrogen.

Can use other antioxidant/free radical scavenger, such as ascorbic acid (vitamin C), tocopherol (vitamin E), tocopherol sorbic acid ester, tocopherol acetas, other ester of tocopherol, 6-hydroxyl-2,5,7,8-tetramethyl benzo dihydropyran-2-carboxylic acid is (with trade name Trolox ^rcommercially available), amine is (as N, N-diethyl hydroxylamine, amino-guanidine), nordihydroguaiaretic acid, bioflavonoids, aminoacid, silymarin, sorbic acid and salt thereof, thioctic acid, Fructus Canrii Albi extract, green tea extract, Ramulus et Folium Mussaendae Pubescentis extract, black tea extract, polyphenol, such as the oligomeric proanthocyanidin, carotenoid, the curcumin compound that derive from pinaster bark, such as tetrahydrocurcumin, OCTA(L-2-oxo-4-thiazolidinecarboxylic acid), glutathion and Pericarpium Vitis viniferae/seed extract.The optional ester from tocopherol of suitable antioxidant/free radical scavenger, such as tocopherol acetas.

In one embodiment, compositions comprises tocopherol sorbic acid ester.As used herein, " tocopherol sorbic acid ester " refers to the sorbate of tocopherol, and its specific embodiment can be present in the United States Patent (USP) 5,922,758 of announcement.In one embodiment, by weight of the composition, compositions can comprise approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 50%, 25%, 20%, 10%, 7% or 5% tocopherol sorbic acid ester.

19. conditioners

Personal care composition of the present invention can comprise the conditioner of safe and effective amount, is selected from for example wetting agent, wetting agent, occludent and can be applied to the emollient of collenchyme.In one embodiment, by weight of the composition, compositions can comprise one or more conditioners of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 50%, 25%, 20%, 10%, 7% or 5%.

Wetting agent is one group of conditioner.Wetting agent can be selected from polyhydric alcohol, water soluble alkoxylated non-ionic polymers and their mixture.Can be used for polyhydric alcohol herein and comprise glycerol, sorbitol, propylene glycol, butanediol, pentanediol, hexanediol, ethoxylated glucose, 1,2-hexanediol, hexanetriol, dipropylene glycol, erithritol, trehalose, two glycerol, xylitol, maltose alcohol, maltose, glucose, fructose, sodium chondroitin sulfate, hyaluronate sodium, hyaluronic acid, adenylic acid sodium, sodium lactate, ketopyrrolidine carbonate, glycosamine, cyclodextrin and their mixture.

Can be used for water soluble alkoxylated non-ionic polymers of the present invention and comprise that molecular weight mostly is approximately 1000 Polyethylene Glycol and polypropylene glycol most, as CTFA name is called those of PEG-200, PEG-400, PEG-600, PEG-1000 and their mixture.

Other conditioner includes but not limited to guanidine, urea, glycolic, glycollate (as ammonium and season alkylammonium), salicylic acid, lactic acid, lactate (as ammonium and season alkylammonium), any Aloe (as Aloe gel) in its various forms, Polyethylene Glycol, sugar (as 6-(.alpha.-D-galactosido)-D-glucose .), cellulose, dextrin, starch, sugar and starch derivant is (as alkoxylate glucose, fucose), lactamide monoethanolamine, acetamide monoethanolamine, pantothenylol, allantoin, amylose, hyaluronic acid, hyaluronate sodium, beta glucan, glycogen, alginic acid, gala arabinan, and their mixture.

The extract that comprises polysaccharide comprises following material: TriMoist KMF(Mibelle AG Biochemistry), with (Solabia Group), Aquaxyl ^tM(Seppic), Pheohydrane P(Barnet Products Corporation), Aesthigel(Barnet Products Corporation), Pentacare HP(Pentapharm) and Hyalurosmooth(Laboratoires Serobiologiques).

Also can be used for herein be propoxylated glycerol, be described in United States Patent (USP) 4,976, in 953.Also that available is various C ₁-C ₃₀the polyester of monoesters and sugar and associated materials.These esters are derived from sugar or polyol moiety and one or more carboxylic moiety.Other suitable conditioner is described in United States Patent (USP) 5,750, in 122,5,674,478,4,529,586,4,507,280,4,663,158,4,197,865,4,217,914,4,381,919 and 4,422,853.

20. antiinflammatories

Steroid antiinflammatory, can include but not limited to corticosteroid, for example hydrocortisone.In addition, non-steroidal anti-inflammatory agent can be used for herein.The multiple compounds of being contained by this group is well-known to those skilled in the art.The concrete non-steroidal anti-inflammatory agents can be used in the present composition includes but not limited to Salicylate, flufenamic acid, etofenamate, aspirin and their mixture.

Can be used for the compound that additional antiinflammatory herein comprises allantoin and Radix Glycyrrhizae (plant genus/Glycyrrhiza glabra L. material), comprise enoxolone, glycyrrhizic acid and their derivant (as salt and ester).

In one embodiment, by weight of the composition, compositions can comprise one or more antiinflammatories of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 50%, 25%, 20%, 10%, 7% or 5%.

21. U.S. black active substances

Compositions of the present invention can comprise U.S. black active substance.In one embodiment, by weight of the composition, compositions can comprise approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 50%, 25%, 20%, 10%, 7% or 5% the black active substance of U.S..The black active substance of suitable U.S. is dihydroxy acetone.

22. skin lightening agents

Compositions of the present invention can comprise skin lightening agent.In one embodiment, by weight of the composition, compositions can comprise one or more skin lightening agents of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 50%, 25%, 20%, 10%, 7% or 5%.Suitable skin lightening agent comprises in this area it being known those, comprises ascorbyl glucoside, kojic acid, hydroquinone arbutin and tranexamic acid.Being applicable to other bright skin material herein can comprise (Cognis), (Rona), Azeloglicina (Sinerga) and extract (as mulberry extract).Exemplary skin lightening agent is ascorbyl glucoside.Other bright skin active substance comprises Féraud stamen gold and Féraud stamen gold BG(sugar Thallus Laminariae (Thallus Eckloniae) extract), deoxyarbutin, sucrose dilaurate, Bakuchiol, pyronine, foxtail millet, octadecene diacid, cinnamic acid, ferulic acid, flower of mustard extract (achromaxyl), methylnicotinamide, oil-soluble Radix Glycyrrhizae extract, folic acid, 9-undecylenic acid, Zinc Undecenoate, L-Trp, thiamine HCl, hexyl resorcin, sharp the miaow red wine polyphenols of rattling away, carnosine (dragosine), gentisic acid methyl ester, inositol, 1, 2-hexanediol and 1, 2-ethohexadiol (with Symdiol68 purchased from Symrise), brown alga extract (laminaine), their salt, their derivant, their precursor, and their combination.Suitable skin lightening agent is also disclosed in U.S. Patent Application Publication US2010/0189669A1.

23. plant extracts

Personal care composition can comprise plant extract.In one embodiment, by weight of the composition, compositions can comprise one or more plant extracts of approximately 0.0001%, 0.0005%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 30%, 25%, 20%, 10%, 7%, 5%, 3%.Suitable plant extract comprises from plant (Rhizoma et radix valerianae, root, flower, fruit, seed) extract, such as flower, fruit, vegetable etc., comprise culture propagation extract, cockle algae extract, thermus thermophilus fermented product extract, Caulis et Folium Lini shepherd's purse seed oil, boswellia serrata tree extract, Fructus Canrii Albi extract, arabidopsis extract, silver chaste tree extract, silvery white maple (sugar maple), acidophilic bacteria, Rhizoma Acori Graminei, Aesculus chinensis Bunge, Alcaligenes, polysaccharide, Larch agaric, Folium Agaves variegatae, Radix Agrimoniae, algae, Aloe, citrus, Btassica, Cortex Cinnamomi, orange, Fructus Mali pumilae, blue berry, Pericarpium Citri tangerinae, Fructus Persicae, pears, Fructus Citri Limoniae, Citrus aurantium Linn., Semen Pisi sativi, Sargassum, caffeine, green tea, Chamomile, Salix alba bark, mulberry, poppy flower etc.Other concrete example includes but not limited to Glycyrrhiza glabra L., black willow, pyriform capsule Macrocystis pyrifera (L.) Ag., Fructus Mali pumilae, Herba Saxifragae, Fructus Vitis viniferae, black Mulberry, Radix Scutellariae, Flos Matricariae chamomillae, Salvia japonica Thunb., Herba Rosmarini Officinalis, Fructus Citri, Semen Ginkgo, Radix Ginseng, Herba Siegesbeckiae, Fructus Mume, yellow tang, lactobacillus bifidus, wild soybean extract, Radix Betae, Balkan lettuce tongue, Rhizoma Polygoni Cuspidati, Citrus, Fructus Vitis viniferae, Herba Lycopodii pulcherrimi, Fols lupuli, peel of Citrus reticulata Blanco, Punica granatum L., key shape hair algae, Rhizoma Curcumae Longae, Herba menyanthis, Helianthi, Fructus Hordei Vulgaris, Fructus Cucumidis sativi, Evernia, oak moss lichens, narrow leaf Thallus Laminariae (Thallus Eckloniae), Ke Shi Thallus Laminariae (Thallus Eckloniae), palmate Thallus Laminariae (Thallus Eckloniae), palmate Thallus Laminariae (Thallus Eckloniae), north Thallus Laminariae (Thallus Eckloniae), Thallus Laminariae (Thallus Eckloniae), Laminaria longissima, profit buttocks Thallus Laminariae (Thallus Eckloniae), wedge base Thallus Laminariae (Thallus Eckloniae), sugar Thallus Laminariae (Thallus Eckloniae), and their mixture.Other suitable active substance is listed in the International Cosmetic Ingredient Dictionary and Handbook of Personal Care Product Council, the 13 edition, in " Biological Products " functional category in 2010.

24. antimicrobial, antibacterial and antifungus active substance

Personal care composition can comprise antimicrobial or antifungus active substance.The antimicrobial of safe and effective amount or antifungus active substance can be added in this compositions.In one embodiment, by weight of the composition, compositions can comprise approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 30%, 25%, 20%, 10%, 7%, 5% or one or more antimicrobial of 3%, antibacterial and/or antifungus active substance.

Can be used for suitable active substance herein comprises and is selected from following those: benzoyl peroxide, 3-hydroxy benzoic acid, glycolic, lactic acid, 4-HBA, 2-hydroxybutyric acid, 2-hydroxypentanoic acid, 2-hydroxycaproic acid, phytic acid, thioctic acid, Azelaic Acid, arachidonic acid, benzoyl peroxide, tetracycline, ibuprofen, naproxen, hydrocortisone, acetaminophen, resorcinol, phenyl phenol, phenoxypropanol, phenoxy group isopropyl alcohol, lignocaine, hydrochlorate, polygynax, and their mixture.

Suitable anti-microbial active matter comprises coal tar, sulfur, whitfield ointment, castellani's paint, aluminum chloride, Gentian Violet, Octopirox (Octopirox ethanolamine), the chloro-2'-dihydroxy diphenyl ether of 2,4,4'-tri-(triclosan), Triclocarban (triclocarban), ciclopirox ethanolamine, 9-undecylenic acid and slaine, potassium permanganate, selenium sulfide, sodium thiosulfate, propylene glycol, the oil of bigarabe, urea preparation, griseofulvin, oxine clioquinol, thiobendazole, thiocarbamate, haloprogin, polyene, pyridone ketone, morpholine, benzylamine, allylamine (such as terbinafine), tea tree oil, Folium Caryophylli oil, coriander, Cymbopogon martini, berberine, Herba thymi vulgaris is red, Oleum Cinnamomi, cinnamic aldehyde, citronellic acid, chamenol, ichthyol is white, Sensiva SC50, the own oxygen phenylate of dihydroxy ethyl sulfonic acid, Azelaic Acid, lyticase, IPBC (IPBC), isothiazolone is as octyl group isothiazolone, and their combination.

Can use azoles antibacterial, and comprise imidazoles, such as benzimidazole, benzothiazole, bifonazole, butunazole nitrate, diazole butanone, clotrimazole, Crewe health azoles, eberconazole, econazole, new health azoles, fenticonazole, fluconazol, flutrimazole, isoconazole, ketoconazole, lanoconazole, metronidazole, miconazole, neticonazole, omoconazole, oxiconazole nitrate, Sertaconazole, sulconazole nitrate, tioconazole, thiazole and triazole are such as terconazole (triaconazole) and itraconazole and their combination.

Selenium sulfide can be used as antibacterial.Selenium sulfide is generally considered to be the compound with one mole of selenium and two molar sulphur, although it also can be, meets general formula Se _xs _ycyclic formula, x+y=8 wherein.As measured by forward laser light scattering device (as, Malvern3600 instrument), the mean diameter of selenium sulfide is less than 15 μ m conventionally, or alternatively, is less than 10 μ m.Selenium sulfide compound is for example described in United States Patent (USP) 2,694,668,3,152,046,4,089,945 and 4,885,107.

Other suitable active substance is listed in the International Cosmetic Ingredient Dictionary and Handbook of Personal Care Product Council, the 13 edition, in " Cosmetic Biocides " functional category in 2010.

25. antiperspirant active

Antiperspirant active also can be included in compositions of the present invention.Suitable antiperspirant active comprises convergence slaine, especially inorganic the and organic salt of aluminum, zirconium and zinc and their mixture.Exemplary active substance comprises material or the salt that contains aluminum and/or contain zirconium, such as aluminum halide, aluminum chlorohydrate, hydroxyhalides, zirconyl oxyhalides zirconium, hydroxyl zirconium halide and their mixture.In one embodiment, by weight of the composition, compositions can comprise one or more antiperspirant compound of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 30%, 25%, 20%, 10%, 7%, 5% or 3%.

26. sensory agents

Personal care composition can comprise warm sensory agent and/or cooling sensory agent.Sensory agent provides heating or cooling sensation to user, but the variation that may or may not produce skin temperature.Feel to can be instantaneous or can be time delay, but in general, can perception in using 5 minutes of skin care compositions.In one embodiment, by weight of the composition, compositions can comprise one or more sensory agents of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 30%, 25%, 20%, 10%, 7%, 5% or 3%.Also can use the mixture of any warm and/or cooling sensory agent.

Suitable warm sensory agent comprises cephrol derivant, comprises cephrol n-butyl ether, cephrol positive propyl ether, cephrol diisopropyl ether, cephrol diisobutyl ether, the positive amino ethers of cephrol, cephrol isoamyl oxide, cephrol n-hexyl ether, cephrol methyl ether and cephrol ether; With the phosphate derivative that comprises aforementioned cephrol derivant, such as cephrol isoamyl oxide monophosphate, cephrol n-butyl ether monophosphate, cephrol n-hexyl ether monophosphate.Other suitable warm sensory agent comprises ethanol, nicotinic acid, Eugenia javanica Lam, nicotinic acid, (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone, cephrol n-butyl ether, cephrol positive propyl ether, cephrol diisopropyl ether, cephrol diisobutyl ether, the positive amino ethers of cephrol, cephrol isoamyl oxide, cephrol n-hexyl ether, cephrol methyl ether, cephrol ether, gingerol, methyl salicylate, shogaol bean bandit alcohol, (4-hydroxy-3-methoxyphenyl)ethyl methyl ketone, capsaicin, dihydrocapsaicin, Nordihydrocapsaicin, homotype capsaicin, homotype dihydrocapsaicin, ethanol, Fructus Capsici tincture, ginger oil resin alcohol extraction, Eucalyptus oil, capsaicin, cinnamic aldehyde, chloroform, ether, isoamyl alcohol, benzylalcohol, allyl isosulfocyanate, ethyl acetate, glycerol, limonene, menthol, 4-hydroxy-4-methyl-cyclohexene-2-ketone-1, and their mixture.Also suitable warm sensory agent comprises solidifying fragrant body or distillate, Rhizoma Zingiberis Recens, Wasabia japonic (Euterma Wasabi), Fructus Capsici, jalapeno, Fructus Piperis, Fructus Capsici, Flos Caryophylli, Cortex cinnamomi japonici (Ramulus Cinnamomi) and their mixture of fluid extraction thing, water-ol extract, quintessence oil, oleoresin, Semen Brassicae Junceae.

Suitable cooling sensory agent comprises menthol, isopulegol, 3-(1-Herba Menthae oxygen base) propane-1, 2-glycol, to terpane-3, 8-glycol, 6-isopropyl-9-methyl isophthalic acid, 4-dioxo spiro-(4, 5)-decane-2-methanol, succinic acid menthyl ester, the alkali salt of succinic acid menthyl ester, cyclonol, N-ethyl-2-isopropyl-5-hexahydrotoluene Methanamide and other Methanamide, as United States Patent (USP) 4, 136, 163 and 4, 230, described in 688, be described in United States Patent (USP) 5, 266, 3-in 592 (1-Herba Menthae oxygen base)-2-methyl-propane-1, 2-glycol, Oleum menthae, mentha piperita oil, Ilicis Purpureae, menthone, menthone glycerol ketals and other glycerol ketals, menthyl lactate, 2-(5'-methyl-2-(Methylethyl) cyclohexyl oxygen base) ethane-1-alcohol, 3-(5'-methyl-2'-(Methylethyl) cyclohexyl oxygen base) propane-1-alcohol, 4-(5'-methyl-2'-(Methylethyl) cyclohexyl oxygen base) butane-1-alcohol and Herba Menthae Rotundifoliae.Other cooling sensory agent comprises terpane-3-base butyl sulphoxide, normal-butyl 1-isobutyl group cyclohexyl sulfoxide, n-hexyl 1-isobutyl group cyclohexyl sulfoxide, normal-butyl 1-isopentyl cyclohexyl sulfoxide and n-hexyl 1,2-diethyl cyclohexyl sulfoxide and other cyclic sulphoxide and sulfone, as United States Patent (USP) 4, described in 032,661.

27. antiseptic

In one embodiment, by weight of the composition, compositions can comprise one or more antiseptic of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 10%, 7%, 5%, 2% or 1%.Determination of Preservatives is suitable, comprises such as benzoic acid, benzylalcohol, benzyl hemiformal, benzyl p-hydroxybenzoate, the bromo-5-of 5-nitro-1,3-dioxane, the bromo-2-of 2-nitropropane-1,3-glycol, butyl p-hydroxybenzoate, phenyl phenol, methyl parahydroxybenzoate, propyl p-hydroxybenzoate, diazonium alkyl imidazole urea, sodium benzoate, calcium benzoate, calcium propionate, 1,2-ethohexadiol, Biguanide derivative, phenyl phenol, captan, chlohexidine diacetate esters, chlohexidine didextrose acid esters, chlohexidine dihydrochloride, chloroacetamide, methaform, parachlorometacresol, benzyl chlorophenol, chlorothymol, chloroxylenol, metacresol, orthoresol, DEDM hydantoin, DEDM hydantoin dilaurate, dehydroactic acid, diazonium alkyl imidazole urea, dibromopropane amidine dihydroxy ethyl sulfonate, DMDM Hydantoin, caprylin, potassium sorbate, salicylic acid, primoline, caprylyl glycine, 1,2 hexanediol, endecatylene acyl glycine, Sensiva SC50, octanohydroxamic acid, methyl propanediol, Hinokitiol, Japanese Cypress sodium alkoxide, phenethanol, levulic acid, p-Methoxybenzoic acid, the bromo-2-of 2-nitropropane-1,3-glycol, N-sodium hydroxy methyl glycinate, iodine propine butyl carbamate, methylchloroisothiazandnone, Methylisothiazolinone, Octopirox ethanolamine, Oleum Cinnamomi, Herba Rosmarini Officinalis extract, (purchased from Bio-Botanica), (purchased from Sinerga) and their combination.In one embodiment, compositions is not containing p-Hydroxybenzoate and/or formaldehyde.

28. anti-dandruff actives

Personal care composition of the present invention also can comprise dandruff agent.In one embodiment, by weight of the composition, personal care composition can comprise one or more anti-dandruff actives of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 20%, 10%, 7%, 5%, 4%, 3% or 2%.The suitable non-limitative example of anti-dandruff particles comprises: pyrithione, azoles, selenium sulfide, drop sulfur and their mixture.In a specific embodiment, can use pyrithione anti-dandruff particles, especially pyrithione salt.Suitable pyrithione comprises by heavy metal, those that form such as zinc, stannum, cadmium, magnesium, aluminum and zirconium.Particularly, can use zinc or the zinc salt (being called " Zinc Pyrithione " or " ZPT ") of pyrithione.Pyrithione salt can be sheet-like particle form, and wherein granule has approximately 20 μ at the most, approximately 5 μ at the most, or the average-size of approximately 2.5 μ at the most.The salt being formed as sodium by other cation is also suitable.The agent of pyrithione dandruff is for example described in United States Patent (USP) 2,809,971,3,236,733,3,753,196,3,761,418,4,345,080,4,323,683,4,379,753 and 4,470,982.Expection, when ZPT is used as to the anti-dandruff particles in this paper compositions, can stimulate or regulate or stimulate simultaneously and regulate growth or the regeneration of hair, or can reduce or suppress trichomadesis, or hair can seems denser or more plentiful.

29. affinity polymer

Personal care composition can comprise one or more affinity polymer.These polymer can be used to strengthen deposition and the life-span of other composition on collenchyme.These polymer also can improve anti-wiping property and water repellency.In one embodiment, by weight of the composition, compositions can comprise one or more affinity polymer of approximately 0.0001%, 0.001%, 0.01%, 0.05%, 0.1%, 0.5% or 1% to approximately 30%, 25%, 20%, 10%, 7%, 5% or 3%.

The cationic polymer being applicable in the present composition comprises cationic nitrogenous part, such as quaternary ammonium or protonated amino cationic moiety.The protonated amine of cation can be primary amine, secondary amine or tertiary amine (preferably secondary amine or tertiary amine), and this depends on concrete kind and the selected pH of described compositions.Can come to associate with cationic polymer with any anionic counter-ion, as long as described polymer keeps in water soluble, in compositions or in the coacervate phase of compositions, and as long as described counter ion counterionsl gegenions are compatible with the solvent of described compositions on physics and chemistry, or can local performance, stability or the aesthetic property that damages product.The non-limitative example of these type of counter ion counterionsl gegenions comprises halogen ion (for example chloride ion, fluorion, bromide ion, iodide ion), sulfate radical and methyl ester sulfate radical.

The non-limitative example of suitable cationic polymer comprises having the vinyl monomer of cation protonated amines or quaternary ammonium functional group and water solublity spacer monomers as the copolymer of acrylamide, Methacrylamide, alkyl and dialkyl group acrylamide, alkyl and dialkyl methyl acrylamide, alkyl acrylate, alkyl methacrylate, vinyl caprolactone or vinyl pyrrolidone.

For being included in the protonated amino of suitable cation and the quaternary ammonium monomer of the cationic polymer of compositions herein, comprise: the vinyl compound replacing with propenoic acid dialkyl aminoalkyl ester, methacrylic acid dialkyl aminoalkyl ester, acrylic acid alkyl monosubstituted amino Arrcostab, methacrylic acid alkyl monosubstituted amino Arrcostab, trialkyl methacryloxy alkylammonium salt, trialkyl acryloxyalkyl ammonium salt, diallyl quaternary ammonium salt, and have such as pyridine , imidazoles for example, with the cation of the quaternized ketopyrrolidine vinyl quaternary ammonium monomer containing azo-cycle, alkyl vinyl imidazoles , alkylvinylpyridines , alkyl vinyl ketopyrrolidine salt.

Other the suitable cationic polymer can be used in compositions comprises l-vinyl-2-pyrrolidone and 1-vinyl-3-Methylimidazole. copolymer (the INCI title: polyquaternary ammonium salt-16) of salt (as chloride salt); The copolymer of l-vinyl-2-pyrrolidone and dimethylaminoethyl methacrylate (INCI title: polyquaternary ammonium salt-11); The polymer of cation diallyl quaternary ammonium, for example comprises, dimethyl diallyl ammonium chloride homopolymer, acrylamide and dimethyl diallyl ammonium chloride copolymer (INCI title is respectively: polyquaternary ammonium salt 6 and polyquaternary ammonium salt 7); Acrylic acid ampholyte copolymer, comprise acrylic acid and dimethyl diallyl ammonium chloride copolymer (INCI title: polyquaternary ammonium salt 22), polyquaternary ammonium salt 39) and the terpolymer of acrylic acid and methacryl amido propyl trimethyl ammonium chloride and methacrylate (INCI title: polyquaternary ammonium salt 47) terpolymer of acrylic acid and dimethyl diallyl ammonium chloride and acrylamide (INCI title:.The monomer that preferred cation replaces is dialkyl aminoalkyl acrylamide, dialkyl aminoalkyl Methacrylamide and their combination that cation replaces.These preferred monomers meet following formula:

R wherein ¹for hydrogen, methyl or ethyl; Each R ², R ³and R ⁴be hydrogen or the short-chain alkyl with approximately 1 to approximately 8 carbon atom independently; N is the integer with approximately 1 to approximately 8 value; And X is counter ion counterionsl gegenions.Be attached to R ², R ³and R ⁴nitrogen can be protonated amines (primary, secondary or tertiary), but preferably quaternary ammonium, wherein R ², R ³and R ⁴in each be alkyl, a non-limitative example is polymethyl acylamino-oxypropyl trimethyl ammonium chloride, with trade name Polycare133 purchased from Rhone-Poulenc.

Other cationic polymer being applicable in compositions comprises polysaccharide polymer, as cationic cellulose derivative and cationic starch derivative.Suitable cationic polysaccharide polymer comprises those that meet following formula:

Wherein A is anhydroglucose residue, such as starch or cellulose anhydroglucose residue; R is alkylidene oxyalkylene, polyoxyalkylene or hydroxyl alkylidene or their combination; R1, R2 and R3 are alkyl, aryl, alkylaryl, aryl alkyl, alkoxyalkyl or alkoxy aryl independently, and each group comprises approximately 18 carbon atoms at the most; And X is anionic counter-ion as described in the text.

Suitable cationic cellulose polymer is the epoxide reactive salt that hydroxyethyl-cellulose and trimethyl ammonium replace, INCI name is called " polyquaternary ammonium salt 10 ", and with they Polymer LR, JR and KG series of polymers purchased from Amerchol Corp.(Edison, N.J., USA).The cationic cellulose of other suitable type comprises the epoxide reactive polymeric quaternary ammonium salts that hydroxyethyl-cellulose and lauryl dimethyl ammonium replace, and INCI name is called " polyquaternary ammonium salt 24 ".These materials with trade name Polymer LM-200 purchased from Amerchol Corp..

Other suitable cationic polymer comprises cationic guar derivative, as guar hydroxypropyltrimonium chloride, its concrete example comprises can be from the commercially available Jaguar of Rhone-Poulenc Incorporated series and can be from Aqualon Division of Hercules, the N-Hance series that Inc is commercially available.Other suitable cationic polymer comprises the cellulose ether containing quaternary nitrogen, and its some examples are described in United States Patent (USP) 3,962, in 418.Other suitable cationic polymer comprises the copolymer of etherified cellulose, melon that and starch, and its some examples are described in United States Patent (USP) 3,958,581.

Compositions herein can comprise non-ionic polymers.For example, can use and there is the poly alkylene glycol that surpasses approximately 1000 molecular weight.These can comprise those with following general formula:

H(OCH ₂CRH) _n-OH

Wherein R is selected from H, methyl and their mixture; And the value of n for selecting, makes the molecular weight of molecule be greater than 1000Da.Preferred polyethylene glycol polymer can comprise that PEG-2M(is also referred to as Polyox n-10, it is purchased from Dow Chemical Co., and is called PEG-2,000); PEG-5M(is also referred to as Polyox n-35 and Polyox n-80, purchased from Dow, and is called PEG-5, and 000 and Polyethylene Glycol300,000); PEG-7M(is also referred to as Polyox n-750, purchased from Dow); PEG-9M(is also referred to as Polyox n-3333, purchased from Dow); With PEG-14M(also referred to as Polyox n-3000, purchased from Dow).

The affinity polymer of suitable commercially available acquisition comprises: the sub-oil base/dimethyl carbonate copolymer of Cosmedia DC(hydrogenated dimer two), and purchased from Cognis; Octyldodecanol or the adipic acid of cyano group diphenylprop enoyl-end-blocking and the copolymer of neopentyl glycol for Polycrylene().Polycrylene has INCI title polyester-8 and purchased from Hallstar Co; Dow Corning FA4001CM siloxanes acrylate and Dow Corning FA4002ID siloxanes acrylate (poly-trimethylsiloxy group methacrylate and by acrylic acid, methacrylic acid or be dissolved in respectively the copolymer of one or more monomers that their one of the simple ester in cyclopentasiloxane or Fancol ID forms); Ganex P-904(gathers (butylation vinyl pyrrolidone)), Ganex V-216(vinyl pyrrolidone and hexadecene copolymer), Ganex V-220(vinyl pyrrolidone and eicosylene copolymer) and Ganex WP-660(vinyl pyrrolidone and 1-melissane copolymer), all purchased from International Specialty Products; Phospholipon90H(hydrolecithin), purchased from Phospholipid GmbH; Dermacryl AQF(acrylate copolymer) purchased from National Starch and Chemical Company; Stantiv OMA-2(vaccenic acid and copolymer-maleic anhydride), purchased from Vertellus Performance Materials, Inc.; The copolymer of Dermacryl-79(octyl acrylamide and one or more monomers of being formed by one of acrylic acid, methacrylic acid or their simple ester), purchased from National Starch and Chemical Company; Copolymer below Allianz OPT(: methacrylic acid, methyl methacrylate, butyl acrylate and methacrylic acid cetyl-eicosyl ester), purchased from International Specialty Products; With Avalure UR450(PPG-17, isophorone vulcabond and dihydromethyl propionic acid copolymer), purchased from Noveon.

Other suitable polymer is disclosed in the 50th section in U.S. Patent Application Publication 2006/0134045A1.

30. detersive surfactants

According to form and function, personal care composition can comprise one or more detersive surfactants.In certain embodiments, personal care composition can be the form of the leave product that can not basically contain clean or detersive surfactant.For example, leave compositions can comprise the cleansing surfactants that is less than 1%, is less than 0.5% cleansing surfactants, or 0% cleansing surfactants.

Described detersive surfactant component can comprise anionic detersive surfactant, amphion or amphoteric detersive surfactants or their combination then.Described detersive surfactant component can comprise anionic detersive surfactant, amphion or amphoteric detersive surfactants or their combination then.These surfactants should be that physics and chemistry is compatible with solvent as herein described, or in other words, should not damage undeservedly stability, aesthetic property or the performance of product.

Suitable anionic detersive surfactant component for this paper compositions comprises those that become known for hair-care or other personal care cleansing compositions.When involved, in compositions, the concentration of anion surfactant component can preferably be enough to provide the clean and foam performance of expectation, by weight of the composition, it generally can be in approximately 1%, 2.5%, 5%, 7.5%, 10%, 12.5% or 15% to approximately 50%, 40%, 30%, 25%, 20% or 10% scope.

The suitable anion surfactant being applicable in compositions is alkyl and alkyl ether sulfate.These materials have corresponding formula ROSO ₃m and RO (C ₂h ₄o) _xsO ₃m, wherein R is the alkyl or alkenyl of approximately 8 to approximately 18 carbon atoms, x is the integer with 1 to 10 value, and M is cation if ammonium, alkanol ammonium are if triethanolamine, monovalence metal are if sodium and potassium and polyvalent metal are as magnesium and calcium.

In certain embodiments, at alkyl and alkyl ether sulfate, in the two, R has approximately 8 to approximately 18 carbon atoms, approximately 10 to approximately 16 carbon atoms, or approximately 12 to approximately 14 carbon atoms.Alkyl ether sulfate is prepared usually used as oxirane and the condensation product with the monohydric alcohol of approximately 8 to approximately 24 carbon atoms.Alcohol can be synthetic, or they can be derived from fat, for example Oleum Cocois, palm-kernel oil, Adeps Bovis seu Bubali.Lauryl alcohol and be preferred derived from the straight chain alcohol of Oleum Cocois or palm-kernel oil.This type of alcohol can and between approximately 0 with approximately between 10, approximately 2 to approximately 5, or the reacting ethylene oxide of approximately 3 molar ratios, and the mixture of gained molecular species (for example having average 3 moles of ethylene oxide of every mol of alcohol) is by sulphation neutralization.

Other suitable anionic detersive surfactant is for meeting formula [R ¹-SO ₃-M] the water soluble salt of organic sulfur acid reaction product, R wherein ¹for thering is the radical of saturated aliphatic alkyl of the straight or branched of approximately 8 to approximately 24 or approximately 10 to approximately 18 carbon atoms; And M is previously described cation.

Other suitable anionic detersive surfactant is for isethionic acid esterification with by the product of the fatty acid of sodium hydroxide neutralization, and wherein for example this fatty acid can be derived from Oleum Cocois or palm-kernel oil; The sodium of the fatty acid amide of methylamino esilate or potassium salt, wherein for example, this fatty acid can be derived from Oleum Cocois or palm-kernel oil.Other similar anion surfactant is described in United States Patent (USP) 2,486, in 921,2,486,922 and 2,396,278.

Other anionic detersive surfactant that is applicable to compositions is succinate, its example comprises that N-disodium octadecyl sulfosuccinate, lauryl disodium sulfosuccinate, lauryl 2-Sulfosuccinic acid diammonium, N-(1,2-dicarboxyl ethyl)-N-octadecyl 2-Sulfosuccinic acid four sodium, the diamyl ester of sodium sulfosuccinate are, the dioctyl ester of the dihexyl of sodium sulfosuccinate and 2-Sulfosuccinic acid sodium salt.

Other suitable anionic detersive surfactant comprises the alkene sulfonate with approximately 10 to approximately 24 carbon atoms.Except proper alkene sulfonate and a part of hydroxyl alkane sulfonate, alkene sulfonate also can comprise other material of trace as alkene disulfonate, and this depends on the ratio of reaction condition, reactant, character and the impurity in olefin feedstock and the side reaction during sulfonation process of initial alkene.The non-limitative example of this type of alpha-alkene sulfonate mixture is described in United States Patent (USP) 3,332, in 880.

Being applicable to another kind of anionic detersive surfactant in personal care composition is β-alkoxy alkane sulfonate.These surfactants meet following formula

R wherein ¹the straight chained alkyl with approximately 6 to approximately 20 carbon atoms, R ²be to have approximately 1 to approximately 3 carbon atom, the preferably low alkyl group of 1 carbon atom, and M is water-soluble cationic as previously described.

The suitable anionic detersive surfactant can be used in described compositions comprises ammonium lauryl sulfate, lauryl polyethenoxy ether sodium sulfate, lauryl sulfate triethylamine, laureth sulphuric acid triethylamine, triethanolamine lauryl sulfate, laureth sulphuric acid triethanolamine, lauryl sulfate monoethanolamine, laureth sulphuric acid monoethanolamine, lauryl sulfate diethanolamine, laureth sulphuric acid diethanolamine, Glyceryl Monolaurate sodium sulfate, sodium lauryl sulfate, sodium laureth sulfate, lauryl potassium sulfate, laureth potassium sulfate, sodium lauryl sarcosinate, sodium lauroyl sarcosine, sarcosine lauryl, cocoyl sarcosine, cocoyl ammonium sulfate, lauroyl ammonium sulfate, sodium cocosulfate, lauroyl sodium sulfate, cocoyl potassium sulfate, lauryl potassium sulfate, triethanolamine lauryl sulfate, triethanolamine lauryl sulfate, cocoyl sulphuric acid monoethanolamine, lauryl sulfate monoethanolamine, tridecyl benzene sulfonic acid sodium salt, dodecylbenzene sodium sulfonate, cocoyl sodium isethionate, and their combination.

Being applicable to both sexes in compositions herein or zwitterionic detersive surfactants comprises and becomes known for those in hair-care or other personal care cleansing.The amphoteric detersive surfactants being applicable in compositions is well known in the art, and comprise those surfactants that are described to widely aliphatic secondary amine and tertiary amines derived thing, wherein aliphatic group can be straight or branched, and wherein one of aliphatic substituent group comprises approximately 8 to approximately 18 carbon atoms, and an aliphatic substituent group comprises anionic group, as carboxyl, sulfonate radical, sulfate radical, phosphate radical or phosphonate radical.Preferred amphoteric detersive surfactants for the present invention comprises cocos nucifera oil acyl both sexes guanidine-acetic acid salt, cocos nucifera oil acyl both sexes base diacetin, lauroyl both sexes guanidine-acetic acid salt, lauroyl both sexes base diacetin and their mixture.The non-limitative example of suitable zwitterionic or amphoteric surfactant is described in United States Patent (USP) 5,104, in 646 and 5,106,609.

The zwitterionic detersive surfactants being applicable in described compositions is well known in this area, and those surfactants that comprise the derivant that is described as widely aliphatic quaternary ammonium, Phosphonium and sulfonium compound, wherein aliphatic group can be straight or branched, and wherein one of aliphatic substituent group comprises approximately 8 to approximately 18 carbon atoms, and an aliphatic substituent group comprises anionic group, for example carboxyl, sulfonate radical, sulfate radical, phosphate radical or phosphonate radical.Zwitterionic compound for example betanin is preferred.

Suitable option list surface-active agent comprises nonionic and cationic surfactant.Any this type of surfactant for hair-care or personal care product as known in the art can be used, precondition is that this optional additional surfactants is also chemical and physical compatibility with the solvent of compositions, or in other words should not damage undeservedly performance, aesthetic property or the stability of product.The non-limitative example that is applicable to other anion in compositions, amphion, both sexes or optional additional surfactants is described in the Emulsifiers and Detergents of the McCutcheon being published by M.C.Publishing Co., 2010 annuals and United States Patent (USP) 3,929,678,2,658,072,2,438, in 091 and 2,528,378.

Any other suitable optional components also can be contained in personal care composition of the present invention, as routine those compositions for given product type.The International Cosmetic Ingredient Dictionary and Handbook of Personal Care Product Council, the 13 edition, the various non-limiting sense material that can be added in this paper compositions has been described for 2010.The example of these sense classifications includes but not limited to: grinding agent, absorbent, aromatic, anti-acne agents, anti-caking agent, defoamer, antimicrobial (as, butyl carbamic acid iodine propyl ester), antifungal, antioxidant, binding agent, buffer agent, extender, chelating agen, coloring agent, cosmetics astringent, cosmetics insecticide, denaturant, medicine astringent, externally-used pain-relieving medicine, film former, opacifier, pH adjusting agent, botanical derivative, plant extract, plant tissue extract, plant seed extract, vegetable oil, botanical, plant extract, antiseptic, propellant, reducing agent, sebum controlling agent, sequestering agent, Porcelana Skin Bleaching Agent Porcelana, skin conditioning agent (as wetting agent and occlusion reagent), and Derma-Guard.Other suitable optional personal nursing composition comprises the material in the 513-839 section of listing in U.S. Patent application 2010/0112100.

exemplary personal care composition

Lower series preparation is the non-limiting imagination example of suitable personal care composition.Where applicable, composition by INCI title as a reference.Although described theme invention with specific embodiment, it will be apparent to those skilled in the art that in the situation that not departing from the spirit and scope of the invention and can make various changes and modification.

Example

Example

Example

1. 12.5% dimethyl siloxane crosspolymer in cyclopentasiloxane.Purchased from Dow Corning.

2. the dimethyl siloxane crosspolymer in cyclopentasiloxane.Purchased from Dow Corning.

3.E.g., Tospearl145A or Tospearl2000.Purchased from GE Toshiba Silicone.

4.PFM(250-500 μ m) painted globule, derives from Kobo.

5. 25% dimethyl siloxane PEG-10/15 cross linked polymer in dimethyl siloxane.Purchased from Shin-Etsu

6. the silicone cross-linked polymer of PEG-15/ lauryl dimethyl in mineral oil, derives from Shin-Etsu.

7.Jeenate3H Tissuemat E.Purchased from Jeen

8. stearyl dimethicone.Purchased from Dow Corning.

9. pair-PEG/PPG-14/14 dimethyl siloxane.Purchased from Degussa

10.PEG-10 dimethyl siloxane, purchased from Shin-Etsu.

The TiO of 11. hydrophobically modifieds ₂coating Muscovitum.Purchased from kobo.

12. dimethyl siloxanes/dimethyl silica alkanol blend, derives from Dow Corning.

13. poly methyl silsesquioxanes, derive from General Electric.

14. Muscovitum and ferrum oxide, derive from Eckart.

15. polyethylene powders, purchased from Equistar.

16. 2 oleoyl ethyl-hydroxyethyl ammonium methyl methylsulfuric acid salt mixtures, purchased from Degussa Care & Surface Specialties, Hopewell, VA.

Mountain Yu base trimethyl ammonium chloride in 17. carriers, purchased from Sanyo Performance Chemicals, JP.

The own oxygen phenylate of 18. dihydroxy ethyl sulfonic acid, purchased from Laboratoires Serobiologiques.

19. hydantoin and iodine propine butyl carbamate blend, purchased from Lonza, Inc.

20. purchased from Ajinomoto U.S.A., Inc., Paramus NJ.

21. have the TiO of water, glycerol, polyacrylate and methyl parahydroxybenzoate ₂, purchased from Kobo Products.

22. polyacrylamides, C13-14 isoparaffin and laureth-7 blend, derive from Seppic.

23., yet be not read as restriction, for alkalescence or the adjustable gellant of exemplary pH of neutral example, comprise N, N'-(2S, 2'S)-1,1'-(hexane-1,6-bis-bases two (azane two bases)) two (3-methyl isophthalic acid-oxo-butanes-2,1-bis-bases) two Pyrazinamides; N, N'-(2S, 2'S)-1,1'-(octane-1,8-bis-bases two (azane two bases)) two (3-methyl isophthalic acid-oxo-butanes-2,1-bis-bases) two Pyrazinamides; And N, N'-(2S, 2'S)-1,1'-(dodecane-1,12-bis-bases two (azane two bases)) two (3-methyl isophthalic acid-oxo-butanes-2,1-bis-bases) two Pyrazinamides.For the adjustable gellant of the pH of acid example, comprise (6S, 14S')-6,14-diisopropyl-4,7,13,16-, tetra-oxo-5,8,12,15-, tetra-azepine nonadecane-1,19-diacid and (6S, 23S)-6,23-diisopropyl-4,7,22,25-, tetra-oxo-5,8,21,24-, tetra-azepine octacosane-1,28-diacid.In some instances, the amount of the adjustable gellant of pH can be approximately 0.01% to approximately 3%.

For example 1, in suitable container, combine the composition of A phase.In an independent suitable container, the composition of combination B phase.Heat each to 75-80 ℃, use suitable blender (as anchor formula blade, propeller blade) to mix each phase, until reach separately temperature and homogenization simultaneously.Slowly B is added to A mutually in, continue to mix A phase simultaneously.Continue to mix until batch of material is even.With Ultra-Turrax homogenizer (IKA, Inc) or equivalent homogenate, and at 75-80 ℃, product is poured in suitable container.Under the moving room temperature of unperturbed, hold-up vessel is at least 12 hours.

For example 2-4,7-10 and 12, in a suitable container, the composition of combination A phase, and mix (heat tracing if necessary) until homogenization with suitable blender.In an independent container, the composition of combination B phase, and mix (heat tracing if necessary) until homogenization with suitable blender.Slowly B is added to A mutually in, continue to mix A phase simultaneously.Continue to mix (heat tracing if necessary) until batch of material is even.With Ultra-Turrax homogenizer (IKA, Inc) or equivalent homogenize product, and product is poured in suitable container.

For example 5-6 and 11, in a suitable container, combination blending constituent (heat tracing if necessary) are until evenly; Can heating combination to dissolve all the components.After described compositions is even, product is poured in suitable container.

In all examples, can by what want to be structured, add mutually the adjustable gellant of pH via the pre-composition of the carrying object of the gellant that comprises design flow and Sq.

use the method for personal care composition

Personal care composition of the present invention can be used for improving or regulating many collenchyme diseases.When using relatively with the method for using personal care composition, " adjusting " refer to keep skin appearance and/or collenchyme sensation in outward appearance and/or sensuously have few deterioratedly to not having, and " improvement " refers to collenchyme outward appearance and/or sensuously affects positive variation.Collenchyme outward appearance and/or sensation beneficial effect can be short-term or long-term beneficial effect.

The collenchyme disease that can be conditioned or improve includes but not limited to thicken collenchyme (as built epidermis and/or corium and/or the hypodermic layer of skin or lip, and be wherein applicable to finger/toenail and hair shaft, comprise ciliary horny layer), atrophy, softening and/or level and smooth, scabies, the outward appearance of black eye and/or swollen eye, sallow, sagging (as saccharification), U.S. black, decortication, scale off and/or increase the metabolism turnover of mammal skin, corse sweat pore, shinny outward appearance, hyperpigmentation, such as hyperpigmentation after inflammation, spider shape blood vessel on mammal skin and/or erythema, microgroove and wrinkle, dry) as roughness, peel off, scale off), honeycomb inflammation and acne.

Other cutin disease that can be conditioned or improve comprises signs of skin aging, includes but not limited to all external observable and appreciable performances of sense of touch, and due to the aging any macroscopic view of collenchyme or microcosmic effect.These signs may be caused by following process, and described process includes but not limited to the development of texture discontinuity, as wrinkle and thick deep wrinkle, microgroove, skin stricture of vagina, crackle, lump, thick pore, inhomogeneities or roughening; Lose skin elasticity; Variable color (comprising black eye); Rash speckle; Sallow; Pigmented skin area is as senile plaque and passeris montani saturati speckle; Keratinization; Abnormal differentiation; Hyperkeratosis; Elastosis; Collagen decomposition; And for example, other histology in horny layer, corium, epidermis, vascular system (, telangiectasis or spider shape blood vessel) and subcutaneous tissue (as fat and/or muscle) (especially near skin those) changes.

Personal care composition of the present invention can be used for improving or regulating the collenchyme of being encroached on." be subject to infringement affect collenchyme " refer to after being for example exposed to physics and/or chemical stimulation, shows discomfort, stimulates, makes us the collenchyme of unhappy or irregular outward appearance etc.The non-limitative example of the collenchyme of being encroached on comprises burn (as sunburn, windburn, chemistry or thermal burn); Erythra (as the erythra of diaper rash, shaving erythra and allergen-induced); Variable color (as bleaching, contamination, hyperpigmentation); Incised wound and otch (as shaving infringement); And dry, cracking or rough skin (as owing to being exposed to for example wind, low temperature and/or low humidity).The non-limitative example of infringement comprises radiation, wind, low humidity, anaphylactogen, pollutant, chemical irritant and natural stimulus object, body fluid, body excretions, excess water, antibacterial, fungus etc.

Regulate and improve keratinous tissue conditions and relate to the present composition that applies safe and effective amount to collenchyme part.The amount of composition applying, the frequency of using and life cycle will change widely according to the active substance of given compositions and the level of other component and adjusting or the improvement of expectation.

In certain embodiments, compositions is applied to collenchyme for a long time, and is more specifically applied to skin.So-called " long-term local application " refers to the life period experimenter, daily or cyclic application compositions within a period of time.The suitable time period comprised at least about one week, at least about one month, at least about three months, at least about six months with at least about 1 year.In the time of this type of continuity, conventionally according to every day rule approximately once use, yet frequency of administration can be from weekly approximately once to every day approximately three times or more times variation at the most.

The various amounts of the present composition can be used to provide skin appearance and/or dermal sensation beneficial effect.A large amount of conventionally use the every cm of compositions that the applied present composition is mg at every turn ²collenchyme, and skin more specifically.Suitable amount of application is about 0.1mg/cm ²to about 20mg/cm ²or about 0.5mg/cm ²to about 10mg/cm ².

The suitable collenchyme that compositions may be utilized comprises any part of face, hair and/or finger/toenail outside.For example, personal care composition can be applied to face, lip, eye pouch region, eyelid, scalp, cervical region, trunk, arm, hands, lower limb, fingernail, toenail, hair of scalp, eyelashes, eyebrow etc.In one embodiment, personal care composition is applied to " skin of face surface ", and this refers to one or more in forehead, socket of the eye week, buccal, mouthful all, lower jaw and nose skin surface.

Leave compositions can be left on collenchyme at least about 15 minutes, at least about 30 minutes, and at least about 1 hour, or the time of a plurality of hours (as over 12 hours).

Can use such as palm and/or finger, instrument (such as cotton balls, swab, pad etc.) and complete using of the present composition.

Described compositions can, from distribution such as bottle, wide mouthed bottle, pipe, folliculus, pouch, container, bottle, bottle, ampoule, powder boxes, maybe can be integrated and be contained in delivery form as in cleaning piece.Useful palm and/or pointed using of the present composition.Use also and can complete by means of device or instrument, such as cotton balls, swab, pad, brush, eye dropper, bubble cottonrose hibiscus, sponge, rod, cleaning piece, foam, nonwoven substrate, facial film, rolling application device, bar-shaped application device, use pen, spray application device, aerosol apparatus, razor etc.Active substance can be comprised in rupturable pouch between two substrates.

method of testing

1. turbidity (NTU)-turbidity (is measured with NTU: nephelometric turbidity unit) use Hach2100P scopometer to measure, according to the program being provided by manufacturer, calibrate.With 15mL representative sample filling sample bottle, and add a cover and clean according to operational order.If necessary, by applying vacuum or using ultrasound wave bath to make sample degassed to remove any bubble (referring to procedure operation handbook).Turbidity is used automatic range State selective measurements.

2. viscosity-viscosity is measured on Brookfield viscometer, uses T-C stripe shape spindle, and wherein at 25 ℃, crane is set in 5rpm

3. (MGC) – MGC calculates by pipe reversal process MGC, and the method is based on R.G.Weiss, P.Terech; " Molecular Gels:Materials with self-assembled fibrillar structures " 2006, Springer, the 243rd page.In order to determine MGC, complete three screenings:

A) screening for the first time: from 0.5% to 5.0 % by weight increases the adjustable gelling agent concentration of pH with 0.5% step-length and prepares a plurality of bottles

B) determine wherein the interval of gel formation (sample of a reversion still flows and the next one has been strong gel).If there is no gel formation at 5% time, use higher concentration.

C) programmed screening: with the step-length of 0.1 % by weight, increase the concentration of the adjustable gellant of pH, in screening for the first time, in definite interval, prepare a plurality of bottles.

D) determine wherein the interval of gel formation (sample of a reversion still flows and the next one has been strong gel).

E) screening for the third time: in order to there is point-device MGC percentage ratio, with the operation screening for the third time in definite interval in programmed screening of 0.025 % by weight step-length.

F) MGC (MGC) for forming the least concentration (not flowing in the reversion at sample) of gel in screening for the third time.

For screening each time, sample is prepared as follows and processes: the bottle of 8mL (Borosilacate glass, there is polytetrafluoroethylene top cover, with reference to B7857D, Fisher Scientific Bioblock) with 2.0000 ± 0.0005g(KERN ALJ120-4 analytical balance, have ± 0.1mg precision) we want the liquid (comprising the adjustable gellant of liquid detergent composition and pH) of determining MGC to fill.Use nut sealed vial, and stay 10 minutes (9.5L at 25 ℃, and operates under 100% power for Elma Transsonic T710DH, 40kHz) in ultra sonic bath, to solid is scattered in liquid.Then by using heat gun (Bosch PHG-2) heating to obtain completely, dissolve, and gentle mechanical agitation bottle.The solution of observing clarification is completely vital.Operate carefully bottle.Although they are manufactured into high temperature resistant, high solvent pressure may cause bottle blast.Bottle is cooled to 25 ℃ 10 minutes (Compatible Control Thermostats, has controller CC2, D77656, Huber) in temperature chamber.Reversion bottle, keeps reversion 1 minute, then observes which sample and does not flow.After screening for the third time, after this time, the concentration of immobilising sample is MGC.For those skilled in the art, obviously between the period of heating, can form solvent vapo(u)r, and when cooling sample, these steam can condensation on the top of gel.When bottle is inverted, the steam of this condensation will flow.This is deducted during observation cycle.If do not have gel to obtain in concentration interval, must the higher concentration of assessment.

Size disclosed herein and value should not be understood to be strictly limited to described accurate numerical value.On the contrary, except as otherwise noted, each this type of size is intended to represent the value quote and around the scope being equal in the function of this value.For example, disclosed size " 40mm " is intended to represent " about 40mm ".

Unless expressly excluded or otherwise limited, every piece of document by quoting herein, comprises any cross reference or Patents or patent application, is all incorporated herein by reference in full accordingly.The quoting of any document is not it as disclosed herein or be subject to the prior art of any invention of claims protection; or its individually or with any combination of any other list of references, or with reference to, propose, suggestion or disclose the approval of any this type of invention.In addition, in the present invention, any implication of term or while defining contradiction in any implication of term or definition and the file that is incorporated to way of reference, should obey implication or the definition of in the literature, giving this term.

Although illustrate and described specific embodiment of the present invention, it should be apparent to those skilled in the art that and in the situation that not departing from the spirit and scope of the invention, can make many other change and modification.Therefore, appended claims is intended to contain all these type of changes and the modification in the scope of the invention.

Claims (11)

1. a personal care composition, comprises the adjustable gellant of pH, and the gellant that wherein said pH is adjustable has the following formula that is selected from:

R wherein ₁and R ₂for amino-functional end group; L ₁for thering is the main chain part of 14 to 500g/mol molecular weight; And L at least ₁, R ₁or R ₂one of comprise pH sensitive group;

R wherein ₅for amino-functional part; L ₂for thering is the main chain part of 14 to 500g/mol molecular weight, and L at least ₂or R ₅one of comprise pH sensitive group; With

C. their mixture;

The gellant that wherein said pH is adjustable has 1 to 30 pKa; And

Wherein said personal care composition is leave compositions.

2. a personal care composition for emulsion form, comprises the adjustable gellant of water, oil phase and pH, and the gellant that described pH is adjustable has the following formula that is selected from:

R wherein ₁and R ₂for amino-functional end group; L ₁for thering is the main chain part of 14 to 500g/mol molecular weight; And L at least ₁, R ₁or R ₂one of comprise pH sensitive group;

R wherein ₅for amino-functional part; L ₂for thering is the main chain part of 14 to 500g/mol molecular weight, and L at least ₂or R ₅one of comprise pH sensitive group; With

C. their mixture; The gellant that wherein said pH is adjustable has 1 to 30 pKa.

3. a personal care composition, comprises

The gellant that a.pH is adjustable, the gellant that described pH is adjustable has the following formula that is selected from:

R wherein ₁and R ₂for amino-functional end group; L ₁for thering is the main chain part of 14 to 500g/mol molecular weight; And L at least ₁, R ₁or R ₂one of comprise pH sensitive group;

R wherein ₅for amino-functional part; L ₂for thering is the main chain part of 14 to 500g/mol molecular weight, and L at least ₂or R ₅one of comprise pH sensitive group; With

Iii. their mixture; The gellant that wherein said pH is adjustable has 1 to 30 pKa; With

B. be selected from following active substance or reagent: osamine, vitamin, control oil preparation, plant sterol, primoline compound, the agent of compacting, anti-wrinkle active substance, anti-atrophy active substance, flavonoid, N-acyl amino acid compound, retinoid, peptide, particulate matter, UV active substance, light stabilizer, the scorching agent of anti-cellulite, desquamation active substance, anti-acne active substance, antioxidant, free radical scavenger, conditioner, antiinflammatory, U.S. black active substance, skin lightening agent, plant extract, anti-microbial active matter, antifungus active substance, antibacterial substance, antiperspirant active, sensory agent, antiseptic, anti-dandruff active, affinity polymer, detersive surfactant, and their combination.

4. according to the personal care composition described in claim 1,2 or 3, the gellant that wherein said pH is adjustable has 1.5 to 14 pKa.

5. according to the personal care composition described in claim 1,2 or 3, the gellant that wherein said pH is adjustable has 150 to 1500g/mol molecular weight.

6. according to the personal care composition described in claim 1,2 or 3, the gellant that wherein said pH is adjustable has 0.1 to 100mg/mL MGC (MGC) under the pH of compositions.

7. The personal care composition according to 1, 2 or 3, wherein the preceding claims, wherein the pH is adjusted to the gelling agent is selected from an amido group: N, N '- (2S, 2'S) -1,1' - (1,2-oxide-bis (N alkane diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl) isonicotinamide; N, N '- (2S , 2'S) -1,1 '- (1,3-diyl bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl) isonicotinate amide; N, N '- (2S, 2'S) -1,1' - (butane-1,4-bis (Prozac diyl)) bis (3-methyl-1-oxo-butane - a 2,1-diyl) isonicotinamide; N, N '- (2S, 2'S) -1,1' - (1,5-bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl) isonicotinamide; N, N '- (2S, 2'S) -1,1' - (hexane-1,6-bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl) isonicotinamide; N, N '- (2S, 2'S) -1,1' - (hept-alkyl -1,7-bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl) isonicotinamide; N, N '- (2S, 2'S) -1,1 '- (1,8-diyl bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl) isonicotinate amide; (6S, 13S ') - 6,13- diisopropyl -4,7,12,15- four oxo -5,8,11,14- octadecyl -1,18- two tetraazabenzo acid; (6S, 14S ') - 6,14- diisopropyl -4,7,13,16- four oxo -5,8,12,15- nonadecyl -1,19- two tetraazabenzo acid; (6S, 15S ') - 6,15- diisopropyl -4,7,14,17- four oxo -5,8,13,16- eicosane 1,20-tetraazabenzo acid; (6S, 16S ') - 6,16- diisopropyl -4,7,15,18- four oxo -5,8,14,17- tetraazabenzo heneicosanoic -1,21- acid; (6S, 17S ') - 6,17- diisopropyl -4,7,16,19- four oxo -5,8,15,18- tetraazacyclododecane docosane -1,22 - acid; (6S, 18S ') - 6,18- diisopropyl -4,7,17,20- four oxo -5,8,16,19- tetraazabenzo tricosa-1, 23- acid; (6S, 19S ') - 6,19- diisopropyl -4,7,18,21- four oxo -5,8,17,20- tetraazabenzo tetracosa-1 , 24 acid; (6S, 20S ') - 6,20- diisopropyl -4,7,19,22- four oxo -5,8,18,21- tetraaza pentacosane - 1,25 acid; (6S, 21S ') - 6,21- diisopropyl -4,7,20,23- four oxo -5,8,19,22- tetraaza hexacosane -1,26- acid; (6S, 22S ') - 6,22- diisopropyl -4,7,21,24- four oxo -5,8,20,23- tetraaza twenty-seven alkoxy -1,27- acid; (6S, 23S ') - 6,23- diisopropyl -4,7,22,25- four twenty-oxo -5,8,21,24- tetraazabenzo octadecyl -1,28- acid; N, N '- (2S, 2'S) -1,1' - (1,2-ethane diyl bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl) bis (4- (1H- imidazol-5-yl) benzamide); N, N '- (2S, 2'S) -1,1' - (propane-1,3-diyl bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl) bis (4- (1H- imidazol-5-yl) benzamide N, N '- (2S, 2'S) -1,1' - (1,4-butane-diyl bis (Prozac diyl)) bis (3-methyl-1-oxo-butane 2,1-diyl) bis (4- (1H- imidazol-5-yl) benzamide); N, N '- (2S, 2'S) - 1,1' - (1,5-pentane - diyl bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl) bis (4- (1H- imidazol-5-yl) benzamide); N, N '- (2S, 2'S) -1,1' - (hexane-1,6-bis (Prozac diyl)) bis (3-methyl-1-oxo-butane -2, 1-yl) bis (4- (1H- imidazol-5-yl) benzamide); N, N '- (2S, 2'S) - 1,1' - (1,7-heptane-diyl bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl) bis (4- (1H- imidazol-5-yl) benzamide); N, N '- (2S, 2'S) -1,1' - (1,8-diyl bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-two yl) bis (4- (1H- imidazol-5-yl) benzamide); N, N '- (2S, 2'S) -1,1' - (1,9-nonane bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl) bis (4- (1H- imidazol-5-yl) benzamide); N, N '- (2S , 2'S) -1,1 '- (1,10-decane bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl) bis (4- (1H- imidazol-5-yl) benzamide); N, N '- (2S, 2'S) -1,1' - (1,11-undecane-bis (Prozac diyl) ) bis (3-methyl-1-oxo-butane-2,1-diyl) bis (4- (1H- imidazol-5-yl) benzamide); N, N '- (2S, 2'S) 1,1 '- (1,12-diyl bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl) bis (4-(1H- imidazol-5-yl) benzamide); N, N '- (2S, 2'S) -1,1' - (1,9-nonane bis (Prozac diyl)) bis (methyl-1-oxo-butane-2,1-diyl) isonicotinamide; N, N '- (2S, 2'S) -1,1' - (1,10-decane-diyl bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl) isonicotinamide; N, N '- (2S, 2'S) -1,1'- (1,11-undecane-bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl) isonicotinamide; N, N'- (2S, 2'S) -1,1 '- (1,12-diyl bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl ) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1' - (1,13-tridecane-diyl bis (Prozac diyl)) bis (3-methyl-oxo-butane 2,1-diyl) isonicotinamide; N, N '- (2S, 2'S) -1,1' - (1,14-tetradecane-bis (Prozac diyl )) bis (3-methyl-1-oxo-butane-2,1-diyl) isonicotinamide; N, N '- (2S, 2'S) -1,1' - (-1 hexadecane , 16-diyl bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl) isonicotinamide; N, N '- (2S, 2'S) - 1,1 '- (octadecyl -1,18- diyl bis (Prozac diyl)) bis (3-methyl-1-oxo-butane-2,1-diyl) isonicotinamide; N, N '- (2S, 2'S) -1,1' - (1,2-ethane diyl bis (Prozac diyl)) bis (1-oxo-propane-2,1-diyl) isonicotinamide; N, N '- (2S, 2'S) -1,1' - (1,3-diyl bis (Prozac diyl)) bis (1-oxo-propane-2,1-two diyl) isonicotinamide; N, N '- (2S, 2'S) -1,1' - (1,4-butane-diyl bis (Prozac diyl)) bis (1-oxo-propane -2 , l-diyl) isonicotinamide; N, N '- (2S, 2'S) -1,1' - (1,5-bis (Prozac diyl)) bis (1-oxy-substituting propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1' - (hexane-1,6-bis (Prozac diyl)) bis (1-oxo-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1' - (1,7-heptane-bis (Prozac two yl)) bis (1-oxo-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1' - (1,8-bis-diyl (Prozac diyl)) bis (1-oxo-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1' - (1,9-nonane - diyl bis (Prozac diyl)) bis (1-oxo-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1' - (decane 1,10-bis (Prozac diyl)) bis (1-oxo-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1' - (1,11-undecane-bis (Prozac diyl)) bis (1-oxo-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) 1,1 '- (1,12-diyl bis (Prozac diyl)) bis (1-oxo-propane-2,1-diyl) di-iso-nicotinamide; N, N'- (2S, 2'S) -1,1 '- (1,13-tridecane-diyl bis (Prozac diyl)) bis (1-oxo-propane-2,1-diyl) isonicotinamide; N, N '- (2S, 2'S) -1,1' - (1,14-tetradecane-bis (Prozac diyl)) bis (1-oxo-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1' - (hexadecyl -1,16- diyl bis (Prozac diyl)) bis (1-oxo-propane -2, 1-yl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1' - (octadecyl -1,18- diyl bis (Prozac diyl)) bis (1-oxy-substituting propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1' - (1,2-ethane diyl bis (Prozac diyl)) bis (1-oxo-3-phenyl-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1' - (1,3-bis-diyl (Prozac diyl)) bis (1-oxo-3-phenyl-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1' - (D alkyl -1,4-bis (Prozac diyl)) bis (1-oxo-3-phenyl-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S ) -1,1 '- (1,5-bis (Prozac diyl)) bis (1-oxo-3-phenyl-propane-2,1-diyl) isonicotinamide; N, N '- (2S, 2'S) -1,1' - (hexane-1,6-bis (Prozac diyl)) bis (1-oxo-3-phenyl-propane 2,1 - diyl) di-iso-nicotinamide N, N '- (2S, 2'S) -1,1' - (1,7-heptane-bis (Prozac diyl)) bis (1-oxo-3 - phenyl-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1' - (1,8-diyl bis (Prozac diyl) ) bis (1-oxo-3-phenyl-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1' - (1,9-nonane diyl bis (Prozac diyl)) bis (1-oxo-3-phenyl-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1' - (1,10-decane bis (Prozac diyl)) bis (1-oxo-3-phenyl-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1 '- (1,11-undecane-bis (Prozac diyl)) bis (1-oxo-3-phenyl-propane-2,1-diyl) isonicotinamide; N, N '- (2S, 2'S) -1,1' - (1,12-diyl bis (Prozac diyl)) bis (1-oxo-3-phenyl-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1' - (1,13-tridecane-diyl bis (Prozac diyl)) bis (1-oxo-3-phenyl-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1' - (1,14-tetradecane bis (Prozac diyl)) bis (1-oxo-3-phenyl-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1'- (hexadecane -1,16- diyl bis (Prozac diyl)) bis (1-oxo-3-phenyl-propane-2,1-diyl) di-iso-nicotinamide; N, N '- (2S, 2'S) -1,1 '- (octadecyl -1,18- diyl bis (Prozac diyl)) bis (1-oxo-3-phenyl-propane-2,1-diyl) isonicotinamide; (2S) -2 - [[2- (dodecanoyl-amino) acetyl] amino] propanoic acid; (2S) -2 - [[2 - [[2- (dodecanoyl-amino) acetyl] amino] acetyl] amino] propanoic acid; (2S) -2 - [[2- (dodecanoyl-amino) acetyl] amino]-2-phenyl - acetic acid; (2S) -2- [[2-(dodecanoyl-amino) acetyl] amino]-3-methyl - butyrate; 2 - [[2-(dodecanoyl-amino) acetyl] amino] acetic acid; (2S) -2- [[2 (sixteen amido] propanoic acid; and mixtures thereof.

8. according to the personal care composition described in claim 1 and 3, wherein said personal care composition is the emulsion with water and oil phase.

9. according to the personal care composition described in claim 2 and 8, the gellant that wherein said pH is adjustable builds described water.

10. according to the personal care composition described in claim 2 and 8, the gellant that wherein said pH is adjustable builds described oil phase.

11. according to the personal care composition described in claim 2 and 8, also comprises emulsifying agent.