TW202035310A - Hydrogen-dissolved water generating device and hydrogen-dissolved water generating method - Google Patents

Abstract

The present invention provides a technology capable of controlling generation of hydrogen-dissolved water based on hydrogen delivered to a patient's body in hemodialysis treatment using hydrogen-dissolved water. The hydrogen-dissolved water generating device (1) is a device for generating hydrogen-dissolved water obtained by dissolving hydrogen into water. The hydrogen-dissolved water generating device (1) includes: a hydrogen water generating unit (3) that is configured to generate hydrogen-dissolved water; a detection unit (12) that is configured to detect hydrogen contained in the blood of a patient (H) undergoing dialysis using a dialysate prepared with hydrogen-dissolved water; and a control unit (13) that is configured to control the hydrogen water generating unit (3) according to a detection result of the detection unit (12).

Description

Hydrogen-dissolved water generating device and hydrogen-dissolved water generating method

The present invention relates to a hydrogen-dissolved water generating device and a hydrogen-dissolved water generating method for generating hydrogen-dissolved water used in the preparation of dialysate.

In hemodialysis treatment, a dialysate prepared using hydrogen-dissolved water in which hydrogen is dissolved helps to reduce the oxidative stress of patients, and therefore has attracted attention in recent years (for example, refer to Patent Document 1).

Prior technical literature

Patent literature

Patent Document 1: JP Patent Publication No. 5840248

In view of this, our inventors devoted themselves to further research, and proceeded to develop and improve, hoping to develop a better invention to solve the above problems, and after continuous experimentation and modification, the invention came out.

(The problem to be solved by the invention)

In the dialysis treatment using the device disclosed in Patent Document 1, it is not clear to what extent hydrogen is delivered to the patient's body, and it is desired to establish a technology for controlling the generation of dissolved hydrogen based on the hydrogen delivered to the body.

The present invention is proposed in view of the above facts, and its main purpose is to provide a technology for controlling the production of dissolved hydrogen based on the hydrogen delivered to the patient's body in hemodialysis treatment using hydrogen-dissolved water.

(Technical solution to solve the problem)

The first invention of the present invention is a hydrogen-dissolved water generating device for generating hydrogen-dissolved water obtained by dissolving hydrogen in water, the hydrogen-dissolved water generating device including: a hydrogen water generating unit for generating the hydrogen-dissolved water; The detection unit is used to detect the hydrogen contained in the blood of the patient undergoing dialysis using the dialysate prepared with the hydrogen-dissolved water; the control unit is used to control the hydrogen water according to the detection result of the detection unit Production department.

Preferably, in the hydrogen-dissolved water generating device according to the present invention, the detection unit includes: a first detector that detects the hydrogen contained in the blood sent from the patient to the dialyzer And a second detector that detects the amount of the hydrogen contained in the blood returned from the dialyzer to the patient.

Preferably, in the hydrogen-dissolved water generating device according to the present invention, the control unit is based on the difference between the amount of hydrogen detected by the second detector and the amount detected by the first detector. The difference in the amount of the hydrogen gas controls the hydrogen water generator.

Preferably, in the hydrogen-dissolved water generating device according to the present invention, the control unit controls the hydrogen water generating unit based on an average value of the difference.

Preferably, in the hydrogen-dissolved water generating device according to the present invention, the control unit generates the hydrogen-dissolved water based on a cumulative value of the difference.

Preferably, in the hydrogen-dissolved water generating device according to the present invention, the hydrogen-dissolved water generating device further includes a notification unit that notifies the amount or the difference of the hydrogen gas.

Preferably, in the hydrogen-dissolved water generating device according to the present invention, the hydrogen water generating unit includes an anode power supply body and a cathode power supply body for electrolyzing the water, and the control unit controls The current supplied by the anode power supply body and the cathode power supply body for the electrolysis is used to increase or decrease the dissolved hydrogen concentration of the hydrogen dissolved water.

Preferably, in the hydrogen-dissolved water generator according to the present invention, the hydrogen-water generator includes an anode power supply body and a cathode power supply body for electrolyzing the water, and the difference is smaller than a preset value. At the threshold value, the control unit increases the current for the electrolysis supplied to the anode power supply body and the cathode power supply body.

The second invention of the present invention is a hydrogen-dissolved water generating method for generating hydrogen-dissolved water obtained by dissolving hydrogen in water. The hydrogen-dissolved water generating method includes: a generating step, generating the hydrogen-dissolved water; and detecting A step of using the dialysate prepared from the hydrogen-dissolved water to detect hydrogen contained in the blood of a patient undergoing dialysis; and a control step of controlling the dissolved hydrogen concentration of the hydrogen-dissolved water based on the detection result of the hydrogen .

Preferably, in the hydrogen-dissolved water production method according to the present invention, the detection step includes: a first detection step of detecting the hydrogen contained in the blood sent from the patient to the dialyzer And a second detection step of detecting the amount of the hydrogen contained in the blood returning from the dialyzer to the patient, and in the control step, based on the amount detected by the second detection step The difference between the amount of the hydrogen gas and the amount of the hydrogen gas detected by the first detection step controls the dissolved hydrogen concentration.

(Inventive effect)

The hydrogen-dissolved water generator according to the first invention includes: the detection unit that detects the hydrogen contained in the blood of the patient during the dialysis; and the control unit The detection result of the detection unit controls the hydrogen water generating unit. In this way, the production of the hydrogen-dissolved water used for the preparation of the dialysate can be appropriately controlled based on the hydrogen delivered to the patient's body.

The method for producing hydrogen-dissolved water according to the second invention includes: the detection step of detecting the hydrogen contained in the blood of the patient undergoing dialysis; and a control step, based on the detection result of the hydrogen To control the dissolved hydrogen concentration of the hydrogen dissolved water. Thereby, the dissolved hydrogen concentration of the hydrogen-dissolved water used for the preparation of the dialysate can be appropriately controlled based on the hydrogen delivered to the patient's body.

Regarding the technical means of our inventors, several preferred embodiments are described in detail below in conjunction with the drawings, so as to provide a thorough understanding and approval of the present invention.

Hereinafter, an embodiment of the present invention will be described based on the drawings.

FIG. 1 shows a schematic configuration of a dialysis system 100 including a hydrogen-dissolved water generator 1 of this embodiment. The hydrogen-dissolved water generator 1 is a device for generating hydrogen-dissolved water in a dialysis system 100 that uses a dialysate prepared from hydrogen-dissolved water.

The dialysis system 100 includes a reverse osmosis membrane processing device 2, a hydrogen-dissolved water generating device 1, a dialysate preparation device 5, and a dialysis device 6.

The reverse osmosis membrane treatment device 2 purifies the raw water through reverse osmosis treatment, and supplies it to the hydrogen-dissolved water generator 1. Although tap water is generally used as raw water, other water, such as well water, ground water, etc., can be used in addition to this.

The reverse osmosis membrane treatment device 2 includes a water softening treatment device 21, an activated carbon treatment device 22 and a reverse osmosis membrane module 23. The water softening treatment device 21 removes hardness components such as calcium ions and magnesium ions from the raw water to soften the water. The activated carbon treatment device 22 has activated carbon as a fine porous substance, and adsorbs or removes chlorine and the like from the water supplied from the water softening treatment device 21. The reverse osmosis membrane module 23 separates the water supplied from the activated carbon treatment device 22 into treated water purified by the reverse osmosis membrane and concentrated water containing impurities. The treated water purified by the reverse osmosis membrane module 23 is sent to the hydrogen-dissolved water generator 1. On the other hand, the concentrated water that failed to pass through the reverse osmosis membrane is discharged to the outside of the reverse osmosis membrane treatment device 2.

The hydrogen-dissolved water generator 1 hydrogenates the water purified by the reverse osmosis membrane processing unit 2 to generate hydrogen-dissolved water. The hydrogen-dissolved water generator 1 includes a hydrogen-dissolved water generator 3 for generating hydrogen-dissolved water (hydrogen-containing water) in which hydrogen gas is dissolved. In this embodiment, the electrolytic cell 4 is applied as a part of the hydrogen water generator 3. The details of the electrolytic cell 4 will be described later. The hydrogen-dissolved water generated by the hydrogen-water generating unit 3 is sent to the dialysate preparation device 5 as dialysate preparation water.

The dialysate preparation device 5 uses the dialysate preparation water supplied from the hydrogen water generating unit 3 to prepare a dialysate by, for example, diluting a liquid dialysis agent. The dialysate prepared by the dialysate preparation device 5 is sent to the dialysis device 6.

The dialysis device 6 includes a dialysate supply device 61 and a dialyzer 62. The dialysate supply device 61 sends out the dialysate supplied from the dialysate preparation device 5 to the dialyzer 62. The dialyzer 62 is, for example, an artificial kidney including a dialysis membrane 62a composed of a porous membrane such as hollow fibers, and causes the dialysate supplied from the dialysate preparation apparatus 5 via the dialysis membrane 62a to act on the blood of the patient H undergoing dialysis treatment. Remove metabolic waste and water.

The patient H and the dialyzer 62 are connected through blood circuits 63 and 64. The blood circuit 63 sends the blood collected from the patient H to the dialyzer 62. The blood circuit 63 is provided with a pump 65 for sending out blood. The blood circuit 64 returns the blood from which metabolic wastes and the like have been removed by the dialyzer 62 to the patient H.

The hydrogen-dissolved water generator 1 includes a detection unit 12 for detecting hydrogen contained in the blood of the patient H and a control unit 13 for controlling the hydrogen water generator 3.

The detection unit 12 collects the blood of the patient H, detects the amount of hydrogen per unit volume in the blood, and outputs a corresponding electrical signal to the control unit 13. The detection unit 12 can employ a known hydrogen gas detector or the like. The detection unit 12 of this embodiment is provided in the blood circuits 63 and 64, and detects hydrogen contained in the blood flowing in the blood circuits 63 and 64. It may be configured to supply a part of the blood flowing in the blood circuits 63 and 64 to the detection unit 12.

The control unit 13 includes, for example, a CPU (Central Processing Unit) that executes various arithmetic processing, information processing, and the like, and a memory that stores programs and various information in charge of the operation of the CPU. The control unit 13 is responsible for the control of each unit of the hydrogen-dissolved water generator 1.

More specifically, the control unit 13 controls the hydrogen water generating unit 3 based on the electrical signal input from the detection unit 12, that is, the detection result of the detection unit 12. For example, when hydrogen gas is detected in the blood of the patient H, it can be confirmed that the hydrogen added by the hydrogen water generator 3 is absorbed by the dialysate and blood throughout the body of the patient H. Therefore, the hydrogen water generator 3 The movement weakened or stopped.

On the other hand, if hydrogen is not detected in the blood of the patient H, it can be confirmed that the hydrogen has not spread throughout the body of the patient H. Therefore, for example, the operation of the hydrogen water generating unit 3, that is, the generation of hydrogen-dissolved water is continued. In this case, the control unit 13 may also control the operation of the hydrogen water generating unit 3 to increase the dissolved hydrogen concentration.

Therefore, according to the hydrogen-dissolved water generator 1, it is possible to appropriately control the production of hydrogen-dissolved water used for the preparation of the dialysate based on the hydrogen delivered to the body of the patient H.

FIG. 2 shows the detection part 12. The detection unit 12 includes a first detector 12a and a second detector 12b that detect the amount of hydrogen contained in the blood.

The first detector 12a and the second detector 12b collect blood flowing in the blood circuits 63 and 64, and detect the amount of hydrogen contained in the blood. More specifically, the first detector 12 a is provided in the blood circuit 63 and detects the amount of hydrogen per unit volume in the blood sent from the patient H to the dialyzer 62. The second detector 12b is provided in the blood circuit 64, and detects the amount of hydrogen per unit volume in the blood returned from the dialyzer 62 to the patient H. The detection unit 12 outputs an electric signal corresponding to the amount of hydrogen gas detected by the first detector 12 a and the second detector 12 b to the control unit 13. Thereby, the control unit 13 can know the amount of hydrogen contained in the blood flowing in the blood circuits 63 and 64, respectively, and use it for the control of the hydrogen water generating unit 3.

For example, when the amount of hydrogen detected by the second detector 12b is greater than the amount of hydrogen detected by the first detector 12a, it is considered that the hydrogen in the blood has been absorbed by the patient H. Therefore, by calculating the difference between the amount of hydrogen detected by the second detector 12b and the amount of hydrogen detected by the first detector 12a, the control unit 13 can know the amount of hydrogen absorbed by the patient H, which can be used flexibly In the control of the hydrogen water generator 3.

For example, the control unit 13 calculates the above-mentioned difference in the amount of hydrogen and compares it with a first threshold set in advance, thereby appropriately controlling the hydrogen water generating unit 3. The first threshold value can be defined by, for example, statistically processing information related to the transition of the symptoms of the patient H (hereinafter, the same applies to the second threshold to the sixth threshold). In such a configuration, the hydrogen water generator 3 can be appropriately controlled according to the amount of hydrogen gas that the patient H has absorbed.

In addition, the amount of hydrogen gas may be volume, molecular weight, etc., in addition to mass. In addition, the control unit 13 may be configured to calculate the amount of hydrogen gas absorbed by the patient H per unit time.

In addition, in the present hydrogen-dissolved water generating device 1, the control unit 13 may be configured to control the hydrogen water generating unit 3 based on the average value of the difference in the amount of hydrogen. For example, the control unit 13 controls the hydrogen water generating unit 3 by calculating the average value of the difference in the amount of hydrogen gas and comparing it with a preset second threshold value. The control unit 13 preferably calculates a moving average for each fixed period of time as the average value. In such a configuration, the hydrogen water generator 3 can be appropriately controlled without being affected by slight fluctuations in the concentration of hydrogen in the blood.

In addition, in the present hydrogen-dissolved water generator 1, the control unit 13 may be configured to control the hydrogen water generator 3 based on the cumulative value of the difference in the amount of hydrogen. For example, the control unit 13 calculates the cumulative value of the difference in the amount of hydrogen through the detection unit 12 and compares it with a preset third threshold value, thereby controlling the hydrogen water generating unit 3. In such a configuration, the hydrogen water generator 3 can be appropriately controlled based on the hydrogen gas accumulated in the body of the patient H.

In the present hydrogen-dissolved water generating device 1, it is preferable that a notification unit 14 is further provided, and the notification unit 14 notifies the amount or difference of the hydrogen gas. The notification unit 14 uses, for example, a speaker device that outputs a sound signal and the like in addition to an LED that outputs a light signal. The notification can also use both light and sound signals. The operation of the notification unit 14 is controlled by, for example, the control unit 13. By providing the notification unit 14 in the hydrogen-dissolved water generating device 1, the doctor, nurse or patient H can know through the notification unit 14 that hydrogen has reached the body of the patient H.

FIG. 3 shows the electrolytic cell 4 constituting the hydrogen water generating unit 3. The electrolytic cell 4 electrolyzes water to generate hydrogen molecules. By dissolving the hydrogen molecules in water, hydrogen-dissolved water that is water to which the first hydrogen is added is generated.

The electrolysis cell 4 includes an electrolysis chamber 40, and a first power supply body 41 and a second power supply body 42 are provided in the electrolysis chamber 40. The first power supply body 41 and the second power supply body 42 are installed in the electrolysis chamber 40.

A diaphragm 43 is provided between the first power supply body 41 and the second power supply body 42. The electrolysis chamber 40 is divided into a first electrode chamber 40 a equipped with a first power supply body 41 and a second electrode chamber 40 b equipped with a second power supply body 42 by a diaphragm 43.

The polarities of the first power supply 41 and the second power supply 42 and the voltage applied to the first power supply 41 and the second power supply 42 are controlled by the control unit 13.

The current supply line between the first power supply bodies 41 and 42 and the control unit 13 is provided with a current detector. The current detector detects the electrolysis current supplied to the first power supply body 41 and the second power supply body 42 and outputs an electric signal corresponding to the value to the control unit 13.

The control unit 13 controls the DC voltage applied to the first power supply body 41 and the second power supply body 42 based on the electric signal output from the current detector, for example. More specifically, the control unit 13 performs feedback control on the DC voltage applied to the first power supply body 41 and the second power supply body 42 so that the electrolysis current detected by the current detector becomes a predetermined desired value. For example, when the electrolysis current is too large, the control unit 13 reduces the voltage, and when the electrolysis current is too small, the control unit 13 increases the voltage. Thus, the electrolysis current supplied to the first power supply body 41 and the second power supply body 42 is appropriately controlled.

Hydrogen and oxygen are generated by electrolyzing water in the electrolysis chamber 40. For example, hydrogen gas is generated in the second electrode chamber 40b on the cathode side, and hydrogen-dissolved water in which the hydrogen molecules are dissolved is generated, and the hydrogen-dissolved water is supplied to the reverse osmosis membrane module 23 of the reverse osmosis membrane treatment device 2. In addition, the hydrogen-dissolved water produced with such electrolysis is also called "electrolyzed hydrogen water", and the dialysis treatment using electrolyzed hydrogen water is also called "electrolyzed water dialysis". On the other hand, oxygen gas is generated in the first electrode chamber 40a on the anode side.

As the separator 43, for example, a solid polymer film made of a fluorine-based resin having a sulfonic acid group is used as appropriate. The solid polymer membrane uses electrolysis to move the oxonium ions generated in the first electrode chamber 40a on the anode side to the second electrode chamber 40b on the cathode side as a raw material for generating hydrogen. Therefore, no hydroxide ions are generated during electrolysis, and the pH of the hydrogen-dissolved water does not change.

In this embodiment, the control unit 13 is preferably configured to control the electric current for electrolysis supplied to the first power supply body 41 and the second power supply body 42 based on the difference in the amount of hydrogen gas detected by the detection unit 12 so that The dissolved hydrogen concentration of the hydrogen-dissolved water becomes larger or smaller.

More specifically, when the difference in the amount of hydrogen detected by the detection unit 12 is less than a preset threshold value, the control unit 13 controls the currents for electrolysis supplied to the first power supply body 41 and the second power supply body 42 to be Larger. On the other hand, when the amount of the hydrogen gas is greater than the preset threshold value, the control unit 13 controls the electric current for electrolysis supplied to the first power supply body 41 and the second power supply body 42 to be small.

In addition, when the average value or cumulative value of the hydrogen gas amount detected by the detection unit 12 is less than a preset threshold value, the control unit 13 may be configured to supply the power supply to the first power supply 41 and the second power supply 42 The electrolysis current is controlled to be larger. On the other hand, when the average or cumulative value of the amount of hydrogen is greater than a preset threshold, the control unit 13 can control the current supplied to the first power supply 41 and the second power supply 42 for electrolysis to be small. .

In addition, the control unit 13 may be configured to control the current for electrolysis supplied to the first power supply body 41 and the second power supply body 42 based on the combination of the average value and the cumulative value of the amount of hydrogen per unit volume of exhalation. Get bigger.

FIG. 4 shows the processing process of the hydrogen-dissolved water generating method 500 used in the hydrogen-dissolved water generating device 1. The hydrogen-dissolved water production method 500 is repeatedly executed in the dialysis treatment using hydrogenated dialysate, and includes the production step S1, the detection steps S21, S22, and the control steps S3, S4, and S5.

In the production step S1, the hydrogen-dissolved water is produced by the hydrogen-water production unit 3. During the execution of dialysis treatment, in principle, the generation of hydrogen-dissolved water continues.

In the detection step S21, the blood of the patient H during dialysis is collected. In the present hydrogen-dissolved water generator 1, the detection step S21 is executed by the detection unit 12. In the detection step S22, the detection unit 12 detects the hydrogen contained in the blood collected in the detection step S21. In the control steps S3, S4, and S5, the control unit 13 controls the hydrogen water generator 3 based on the detection result in the detection step S2. For example, when hydrogen gas is detected in the blood (Yes in S3), it can be determined that the hydrogen gas has spread throughout the body of the patient H, and therefore the operation of the hydrogen water generator 3 is weakened or stopped (S4). For example, in the control step S4, the control unit 13 weakens or cuts off the current used for electrolysis.

On the other hand, when hydrogen gas is not detected from the blood (NO in S3), the operation of the hydrogen water generator 3 is controlled (S5) to increase the dissolved hydrogen concentration, and the process returns to S21. For example, in the control step S5, the current used by the control unit 13 for electrolysis increases.

According to the present hydrogen-dissolved water production method 500, the production of hydrogen-dissolved water used for the preparation of dialysate can be appropriately controlled based on the hydrogen delivered to the body of the patient H.

FIG. 5 shows a hydrogen-dissolved water generating method 500A as a modification of the hydrogen-dissolved water generating method 500 of FIG. 4. Regarding the parts not described below in the hydrogen-dissolved water generating method 500A, the treatment process of the above-mentioned hydrogen-dissolved water generating method 500 can be adopted.

In the hydrogen-dissolved water production method 500A, the detection steps S23, S24, S25, and S26 are applied instead of the detection steps S21 and S22 of the hydrogen-dissolved water production method 500, and the control steps S31 and S32 are applied instead of the control step S3.

In the detection step S23, the blood sent from the patient H to the dialyzer 62 is collected by the first detector 12a provided in the blood circuit 63. In the detection step S24, the blood returned to the patient H from the dialyzer 62 is collected by the second detector 12b provided in the blood circuit 64.

In the detection step S25, the amount of hydrogen contained in the blood collected in the detection step S23 is detected. Thus, the amount of hydrogen contained in the blood sent from the patient H to the dialyzer 62 is detected. In the detection step S26, the amount of hydrogen contained in the blood collected in the detection step S24 is detected. Thus, the amount of hydrogen contained in the blood returned from the dialyzer 62 to the patient H is detected.

In the control step S31, the difference between the amount of hydrogen gas detected in the detection step S26 and the amount of hydrogen gas detected in the detection step S25 is calculated. That is, the control unit 13 calculates the above-mentioned difference in the amount of hydrogen by subtracting the amount of hydrogen detected in the detection step S25 from the amount of hydrogen detected in the detection step S26. The above difference in the amount of hydrogen can be considered as the amount of hydrogen that the patient H has absorbed.

In the control step S32, the difference in the amount of hydrogen calculated in the control step S31 is compared with the first threshold. When the difference in the amount of hydrogen gas is equal to or greater than the first threshold value (YES in S32), the process proceeds to S4. It can be configured to return to S21 after executing S4.

On the other hand, when the difference in the amount of hydrogen gas is smaller than the first threshold value (No in S32), after shifting to S5, it returns to S21. In the hydrogen-dissolved water production method 500A, the control unit 13 controls the operation of the hydrogen-water production unit 3 according to the amount of hydrogen that the patient H has absorbed by calculating the difference in the amount of hydrogen, so that the dialysate can be appropriately controlled. The preparation of hydrogen-soluble water.

FIG. 6 shows a hydrogen-dissolved water generating method 500B as a modification of the hydrogen-dissolved water generating method 500A of FIG. 5. Regarding the parts that are not described below in the hydrogen-dissolved water generating method 500B, the processing procedures of the above-mentioned hydrogen-dissolved water generating method 500A and the like can be adopted.

In the hydrogen-dissolved water production method 500B, the control steps S33 and S34 are applied instead of the control steps S31 and S32 of the hydrogen-dissolved water production method 500A. In the control steps S33, S34, S4, and S5, the control unit 13 calculates the average value of the difference in the amount of hydrogen based on the detection results in the detection steps S25 and S26, and controls the operation of the hydrogen water generating unit 3.

That is, in the control step S33, the control unit 13 calculates the average value of the difference in the amount of hydrogen based on the detection results in the detection steps S25 and S26. Then, when the average value of the amount of hydrogen is equal to or greater than the second threshold value (YES in S34), the process moves to S4. On the other hand, when the average value of the amount of hydrogen is less than the second threshold value (No in S34), after moving to S5, it returns to S21. In the hydrogen-dissolved water production method 500B, the operation of the hydrogen-water generator 3 is controlled based on the average value of the hydrogen concentration in the breath. Therefore, it is not affected by the slight fluctuation of the hydrogen concentration in the breath, and can be appropriately Control the generation of hydrogen-dissolved water used in the preparation of dialysate.

FIG. 7 shows a hydrogen-dissolved water generating method 500C as another modification of the hydrogen-dissolved water generating method 500A of FIG. 5. Regarding the parts that are not described below in the hydrogen-dissolved water generating method 500C, the treatment process of the above-mentioned hydrogen-dissolved water generating method 500 can be adopted.

In the hydrogen-dissolved water production method 500C, the control steps S35 and S36 are applied instead of the control steps S31 and S32 of the hydrogen-dissolved water production method 500A. In the control steps S35, S36, S4, and S5, the control unit 13 calculates the cumulative value of the difference in the amount of hydrogen based on the detection results in the detection steps S25 and S26, and controls the operation of the hydrogen water generating unit 3.

That is, in the control step S31, the control unit 13 calculates the cumulative value of the difference in the amount of hydrogen gas detected based on the detection results in the detection steps S25 and S26. Then, when the cumulative value of the difference in the amount of hydrogen is equal to or greater than the third threshold value (YES in S35), the process moves to S4. On the other hand, when the cumulative value of the amount of hydrogen is less than the first threshold value (No in S36), after moving to S5, it returns to S21. In the hydrogen-dissolved water production method 500C, the operation of the hydrogen-water production unit 3 is controlled based on the cumulative value of the difference in the amount of hydrogen. Therefore, it is possible to appropriately control the preparation of the dialysate according to the hydrogen accumulated in the body of the patient H. The generation of dissolved hydrogen water.

Although the hydrogen-dissolved water generator 1 of the present invention has been described in detail above, the present invention is not limited to the specific embodiment described above and can be implemented in various forms. That is, the present hydrogen-dissolved water generator 1 is a device for generating hydrogen-dissolved water obtained by dissolving hydrogen in water, and is equipped with at least a hydrogen-dissolved water generating part 3 for generating hydrogen-dissolved water, and is used to prepare hydrogen-dissolved water. It is sufficient that the detection unit 12 that detects the hydrogen contained in the blood of the patient H undergoing dialysis, and the control unit 13 that controls the hydrogen water generating unit 3 based on the detection result of the detection unit 12.

Therefore, for example, the control unit 13 may be configured to determine that the dialysis is completed when the difference in the amount of hydrogen or the average value exceeds a preset fourth threshold or fifth threshold. In addition, the control unit 13 may be configured to determine that the dialysis is completed when the cumulative value exceeds a preset sixth threshold value.

In addition, the hydrogen water generating unit 3 is not limited to the electrolytic cell 4 that generates hydrogen-dissolved water by electrolyzing water, and may be, for example, a device that dissolves hydrogen molecules generated by the chemical reaction of water and magnesium in water to generate hydrogen-dissolved water. Or it may be a device that dissolves hydrogen (hydrogen molecules) supplied from a hydrogen storage tank in water to generate hydrogen-dissolved water.

In addition, the present hydrogen-dissolved water production method 500 and the like are methods for producing hydrogen-dissolved water obtained by dissolving hydrogen in water, and at least include the production step S1 of producing hydrogen-dissolved water, and the use of a dialysate prepared with hydrogen-dissolved water It is sufficient to detect the detection step S22 of the hydrogen contained in the blood of the patient H undergoing dialysis, and the control steps S3 to S5 to control the dissolved hydrogen concentration of the hydrogen-dissolved water based on the detection result of the hydrogen.

In summary, the technical means disclosed in the present invention can effectively solve the conventional problems and achieve the expected purpose and effect. It has not been seen in the publications, has not been used publicly, and has long-term progress before the application. The patent law claims that the invention is correct. Yan filed an application in accordance with the law and prayed that Jun Shanghui would give a detailed examination and grant a patent for invention.

However, the above are only a few preferred embodiments of the present invention, and should not be used to limit the scope of implementation of the present invention, that is, all equivalent changes and modifications made in accordance with the scope of the patent application of the present invention and the content of the invention specification are all It should still fall within the scope of the invention patent.

〔this invention〕 1: Hydrogen-dissolved water generator 100: Dialysis system 12: Inspection Department 12a: first detector 12b: second detector 13: Control Department 14: Notification Department 2: Reverse osmosis membrane treatment device 21: Softening treatment device 22: Activated carbon treatment device 23: Reverse osmosis membrane module 3: Hydrogen water generation department 4: electrolyzer 40: electrolysis room 40a: first pole chamber 40b: second electrode chamber 41: The first power supply body 42: second power supply body 43: Diaphragm 5: Dialysate preparation device 500: Method of generating dissolved hydrogen water 500A: Method of generating dissolved hydrogen water 500B: Method of generating dissolved hydrogen water 500C: Method for generating dissolved hydrogen water 6: Dialysis device 61: Dialysate supply device 62: Dialyzer 62a: dialysis membrane 63, 64: blood circuit 65: pump S1: Process S2, S21, S22, S23, S24, S25, S26: inspection process S3, S31, S32, S33, S34, S35, S36, S4, S5: control process H: Patient

[Figure 1] is a diagram showing the schematic configuration of a dialysis system including the hydrogen-dissolved water generator of the present invention; [Figure 2] is a diagram showing in detail the detection section of Figure 1; [Figure 3] is a diagram showing an electrolytic cell as an example of the hydrogen water generating section of Figure 1; [Figure 4] is a flowchart showing the processing procedure of the hydrogen-dissolved water generating method used in the hydrogen-dissolved water generating device of Figure 1; [Figure 5] is a flowchart showing the processing procedure of a modification of the hydrogen-dissolved water generating method of Figure 4; [Figure 6] is a flowchart showing the processing procedure of another modification of the hydrogen-dissolved water generating method of Figure 5; [Fig. 7] Fig. 7 is a flowchart showing a processing procedure of still another modification of the hydrogen-dissolved water producing method of Fig. 5.

1: Hydrogen-dissolved water generator

100: Dialysis system

12: Inspection Department

13: Control Department

14: Notification Department

2: Reverse osmosis membrane treatment device

21: Softening treatment device

22: Activated carbon treatment device

23: Reverse osmosis membrane module

3: Hydrogen water generation department

5: Dialysate preparation device

6: Dialysis device

61: Dialysate supply device

62: Dialyzer

62a: dialysis membrane

63, 64: blood circuit

65: pump

H: Patient

Claims (10)

A hydrogen-dissolved water generating device, used to generate hydrogen-dissolved water obtained by dissolving hydrogen in water, The hydrogen-dissolved water generator includes: A hydrogen water generating part, which generates the hydrogen dissolved water; A detection unit for detecting the hydrogen contained in the blood of the patient undergoing dialysis using the dialysate prepared with the hydrogen-dissolved water; and The control unit is configured to control the hydrogen water generating unit based on the detection result of the detection unit. The hydrogen-dissolved water generating device according to claim 1, wherein: The hydrogen-dissolved water generating device includes: a first detector that detects the amount of hydrogen contained in the blood sent from the patient to the dialyzer; and a second detector that detects the return from the dialyzer The amount of the hydrogen contained in the blood of the patient. The hydrogen-dissolved water generating device according to claim 2, wherein: The control unit controls the hydrogen water generating unit based on the difference between the amount of the hydrogen gas detected by the second detector and the amount of the hydrogen gas detected by the first detector . The hydrogen-dissolved water generating device according to claim 3, wherein: The control unit controls the hydrogen water generating unit based on the average value of the difference. The hydrogen-dissolved water generating device according to claim 3 or 4, wherein: The control unit generates the hydrogen-dissolved water based on the cumulative value of the difference. The hydrogen-dissolved water generating device according to any one of claims 1 to 4, wherein: The hydrogen-dissolved water generator further includes a notification unit that notifies the amount of the hydrogen gas or the difference. The hydrogen-dissolved water generating device according to any one of claims 1 to 4, wherein: The hydrogen water generating part includes an anode power supply body and a cathode power supply body for electrolyzing the water, The control part controls the current supplied to the anode power supply body and the cathode power supply body for the electrolysis to increase or decrease the dissolved hydrogen concentration of the hydrogen dissolved water. The hydrogen-dissolved water generating device according to claim 3 or 4, wherein: The hydrogen water generating unit includes an anode power supply body and a cathode power supply body for electrolyzing the water, and when the difference is less than a preset threshold value, the control unit increases the power supply to the anode power supply body and the The current supplied by the cathode power supply for the electrolysis. A method of generating hydrogen-dissolved water, used to generate hydrogen-dissolved water obtained by dissolving hydrogen in water, The method for generating hydrogen-dissolved water includes: Generating process, generating said hydrogen-dissolved water; The detection step uses the dialysate prepared with the hydrogen-dissolved water to detect the hydrogen contained in the blood of the patient undergoing dialysis; and The control step controls the dissolved hydrogen concentration of the hydrogen-dissolved water based on the detection result of the hydrogen gas. The method for producing hydrogen-dissolved water according to claim 9, wherein: The detection step includes: a first detection step of detecting the amount of the hydrogen contained in the blood sent from the patient to the dialyzer; and a second detection step of detecting the return from the dialyzer to the patient The amount of the hydrogen contained in the blood, In the control step, the solvent is controlled based on the difference between the amount of the hydrogen gas detected by the second detection step and the amount of the hydrogen gas detected by the first detection step. Hydrogen concentration.

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