TW202016124A - 對多重耐藥菌具有效果的胺基糖苷類抗生素之製造方法 - Google Patents

對多重耐藥菌具有效果的胺基糖苷類抗生素之製造方法 Download PDF

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Publication number
TW202016124A
TW202016124A TW108118738A TW108118738A TW202016124A TW 202016124 A TW202016124 A TW 202016124A TW 108118738 A TW108118738 A TW 108118738A TW 108118738 A TW108118738 A TW 108118738A TW 202016124 A TW202016124 A TW 202016124A
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TW
Taiwan
Prior art keywords
formula
group
salt
protecting group
compound
Prior art date
Application number
TW108118738A
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English (en)
Chinese (zh)
Inventor
今井貴弘
村裕彰
毛利伸介
梅村英二郎
大安成
高橋良昭
Original Assignee
日商明治製菓藥業股份有限公司
公益財團法人微生物化學研究會
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Publication date
Application filed by 日商明治製菓藥業股份有限公司, 公益財團法人微生物化學研究會 filed Critical 日商明治製菓藥業股份有限公司
Publication of TW202016124A publication Critical patent/TW202016124A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
TW108118738A 2018-05-31 2019-05-30 對多重耐藥菌具有效果的胺基糖苷類抗生素之製造方法 TW202016124A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018105011A JP2021138615A (ja) 2018-05-31 2018-05-31 多剤耐性菌に有効なアミノグリコシド抗生物質の製造方法
JP2018-105011 2018-05-31

Publications (1)

Publication Number Publication Date
TW202016124A true TW202016124A (zh) 2020-05-01

Family

ID=68698941

Family Applications (1)

Application Number Title Priority Date Filing Date
TW108118738A TW202016124A (zh) 2018-05-31 2019-05-30 對多重耐藥菌具有效果的胺基糖苷類抗生素之製造方法

Country Status (3)

Country Link
JP (1) JP2021138615A (ja)
TW (1) TW202016124A (ja)
WO (1) WO2019230863A1 (ja)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5772999A (en) * 1980-10-24 1982-05-07 Shionogi & Co Ltd Novel 5-deoxyapramycin
JPS5772998A (en) * 1980-10-24 1982-05-07 Shionogi & Co Ltd Novel appamycin derivative
US4379917A (en) * 1981-12-24 1983-04-12 Eli Lilly And Company 6"-(Substituted)-apramycin antibiotic derivatives and intermediates and starting materials therefor
US4360665A (en) * 1981-12-24 1982-11-23 Eli Lilly And Company 4"-N-(Substituted)-apramycin antibiotic derivatives and intermediates therefor
WO2012034955A1 (en) * 2010-09-13 2012-03-22 University Of Zurich Treatment of bacterial infectious diseases
MY186959A (en) * 2015-07-30 2021-08-26 Microbial Chem Res Found New effective aminoglycoside antibiotic for multidrug-resistant bacteria
JP2020055749A (ja) * 2017-01-27 2020-04-09 公益財団法人微生物化学研究会 多剤耐性菌に有効な新規アミノグリコシド抗生物質

Also Published As

Publication number Publication date
WO2019230863A1 (ja) 2019-12-05
JP2021138615A (ja) 2021-09-16

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