TW201936054A - A synergistic insecticidal composition comprising METHOMYL and FIPRONIL - Google Patents

Abstract

A composition comprising a synergistic pesticidally effective amount of methomyl and fipronil. The composition is particularly useful for protecting and/or treating crops against insects.

Description

Synergistic insecticidal composition comprising METHOMYL and FIPRONIL

This invention relates to synergistic pesticidal compositions comprising nanoderived and fentanyl and their use for controlling insects. The invention is also directed to the use of the above compositions, particularly in the treatment of seed, leaf and soil application.

Chemical control is an important way to prevent and control agricultural pests. However, today's chemical agents do not show satisfactory results for certain pests. Furthermore, many pesticides have developed resistance to commonly used pesticides due to long-term use of pesticides. Therefore, there is an urgent need to develop new methods and pesticides to control these pests. In addition, the environmental and economic needs imposed on modern insecticides are increasing, for example, with regard to spectrum of action, toxicity, selectivity, application rate, residue formation and advantageous preparation capabilities. Due to possible problems, for example, resistance to known active compounds, the constant task is to develop new insecticides that are at least superior to known counterparts in certain fields.

Nanet (( E , Z )-methyl N-{[(methylamino)carbonyl)oxy}ethylimidomethyl sulfate), also known as Lannate, Mesomile, Methomex and Nudrin, belongs to A plant protectant for urethanes. As generally used against Lepidoptera (Lepidopterous) insect pests and Coleoptera (Coleopterous) and a number of Hemiptera (Hemipterous) of insecticide insect pests. It acts by reversibly inactivating the insecticidal cholinesterase. Common trade names include Acinate, Agrinate, DuPont 1179, Flytek, Kipsin, Lannate, Lanox, Memilene, Methavin, Methomex, Nudrin, NuBait, Pillarmate and SD 14999.

Fenpney (5-amino-1-(2,6-dichloro-α,α,α-trifluoro-p-tolyl)-4-[(trifluoromethyl)sulfinyl]pyrazole- 3-carbonitrile) belongs to a class of insecticides known as phenylpyrazole. Fenpney interferes with chloride ion passage by disrupting CNS activity via a gamma-aminobutyric acid (GABA)-regulated chloride channel. When applied as soil or seed, it is moderately systemic and can be used to control insects. A method for preparing Fenpney is disclosed in WO2013037291 A1.

The present invention is directed to a synergistic pesticidal composition comprising an effective amount of (A) nanobelf and an effective amount of (B) Fenpney.

The term "effective amount" means that the amount of this compound or a combination of such compounds can be avoided in a synergistic manner to control and/or treat pests.

As used herein, "plant" refers to all plants and flora, such as wild plants or crop plants that are desired and not desired.

As used herein, "plant part" refers to all plants and plant organs such as buds, leaves, needles, stalks, stems, fruit bodies, fruits, seeds, roots, tubers and rhizomes. Harvested materials, as well as asexual and reproductive reproductive material also include, for example, cuttings, tubers, meristems, rhizomes, offsets, seeds, single and multiple plant cells, and any other plant tissue.

The word “environment” or “location” refers to the place where the plant grows, where the plant's reproductive material is sowed, or where the plant's reproductive material will be planted.

The invention also relates to methods of avoiding, controlling and/or treating pests, and to the use of such synergistic compositions.

It has now surprisingly been found that when a synergistic pesticidal composition comprising (A) nanodine; and (B) Fenpney is applied to the environment of plants, plant parts and/or the like, in particular cereals, Coffee, fiber plants, legumes, oilseed plants, pastures, sugar cane, trees and vegetables can be observed to avoid, control and/or treat insects. In addition, the application rate of individual components can be significantly reduced while maintaining a high level of insecticidal efficacy. This composition has been found to exhibit a fairly broad spectrum of pest resistance when compared to the component parts alone. The composition has the potential to control pests at low application rates and when individual compounds are not effective alone, the composition is acting at a faster rate than predicted from individual components.

(A) Nanet may be present in the compositions of the invention in any suitable amount, and is usually present in an amount of from about 1% to about 80% by weight of the composition, preferably from about 5% by weight of the composition. From 1% to about 75%, more preferably from about 1% to about 70% by weight of the composition, from about 1% to about 65% or from about 1% to about 60%.

(B) Fenpini can be present in the compositions of the invention in any suitable amount, and is usually present in an amount of from about 1% to about 80% by weight of the composition, preferably by weight of the composition. From 1% to about 75% or from about 1% to about 70%, more preferably from about 1% to about 65%, from about 1% to about 60%, or from about 1% by weight of the composition. It is present to approximately 40%.

The components (A) and (B) together may be present in the compositions of the invention in any suitable amount, and are usually present in an amount of from about 2% to about 95% by weight of the composition, preferably the composition. It is present from about 10% to about 80% by weight, more preferably from about 15% to about 70% by weight of the composition, and more preferably from about 20% to about 8% by weight of the composition. 65% exists.

The components (A) and (B) may be present in the composition or in any amount relative to each other to provide a boost or synergistic effect. Particularly, in the composition, the weight ratio of the component parts (A) and (B) is independently preferably from about 90:1 to about 1:90 or from about 50:1 to about 1:50, more preferably From about 25:1 to about 1:25, and even more preferably from about 12:1 to about 1:12, from about 10:1 to about 1:10, from about 9:1 to about 1:9, From about 8:1 to about 1:8, from about 7:1 to about 1:7, from about 6:1 to about 1:6, from about 5:1 to about 1:5, from about 4:1 to Approximately 1:4, from about 3:1 to about 1:3, from about 2:1 to about 1:2, about 1:1. In some embodiments, the weight ratio of component (A) to (B) in the composition is about 12:1 or 10:1 or 9:1 or 8:1 or 7:1 or 6:1 or 5:1 or 4:1 or 3:1 or 2:1 or 1:1. In some embodiments, the weight ratio of component (A) to (B) in the composition is about 8:1. In some embodiments, the weight ratio of component (A) to (B) in the composition is about 1:1.

In a preferred embodiment of the invention, each combination is a composition comprising component parts (A) and (B) and any one or more adjuvants. The adjuvant employed in the composition will depend on the type of formulation and/or the manner in which the formulation will be administered by the end user. Formulations incorporating the compositions of the present invention are illustrated below. Suitable adjuvants which may be included in the compositions according to the invention are all customary adjuvants or components, such as extenders, carriers, solvents, surfactants, stabilizers, antifoaming agents, antifreeze agents, antiseptic agents Agents, antioxidants, colorants, thickeners, solid adhesives and inert fillers. Such adjuvants are known in the art and are commercially available. The use of such formulations in the compositions of the present invention will be apparent to those skilled in the art.

The composition may further comprise one or more inert fillers. Such inert fillers are known in the art and are commercially available. Suitable solid type fillers include, for example, natural ground minerals such as kaolin, alumina, talc, chalk, quartz, palygorskite, montmorillonite and diatomaceous earth, or synthetic ground minerals such as highly dispersed Acid, alumina, citrate, and calcium phosphate and calcium hydrogen phosphate. Suitable particulate inert fillers include, for example, pulverized and classified natural minerals such as calcite, marble, pumice, sepiolite and dolomite, or synthetic particles of inorganic and organic ground materials, and particles of organic materials, such as Sawdust, coconut shells, corn cobs and tobacco stalks.

The composition optionally comprises one or more surfactants, preferably natural nonionic, cationic and/or anionic surfactants and surfactant mixtures which have good emulsifying, dispersing and wetting properties. Properties, depending on the nature of the active compound being formulated. Suitable surfactants are known in the art and are commercially available. Suitable anionic surfactants can be both so-called water soluble soaps and water soluble synthetic surface active compounds. The soap which can be used is an alkali metal, an alkaline earth metal or an ammonium salt of a substituted or unsubstituted higher fatty acid (C ₁₀ -C ₂₂ ), such as a sodium or potassium salt of oleic acid or stearic acid, or a mixture of natural fatty acids. . The surfactant can be an ionic or nonionic emulsifier, dispersant or wetting agent. Examples which may be used are salts of polyacrylic acid, salts of lignosulfonic acid, salts of benzenesulfonic acid or naphthalenesulfonic acid, condensation polymers of ethylene oxide with fatty alcohols or with fatty acids or with fatty amines, substituted Phenol, especially alkylphenols, sulfosuccinates, taurine derivatives, especially alkyl taurates, or polyethoxylated phenols or phosphates of alcohols. When the active compound and/or the inert carrier and/or adjuvant/adjuvant are water insoluble and the final application of the composition is water, at least one surfactant is typically required to be present.

The composition further optionally comprises one or more polymeric stabilizers. Suitable polymeric stabilizers for use in the present invention include, but are not limited to, polypropylene, polyisobutylene, polyisoprene, copolymers of monoolefins and diolefins, polyacrylates, polystyrene, polyvinyl acetate. , polyurethane or polyamine. Suitable stabilizers are known in the art and are commercially available.

The above surfactants and polymeric stabilizers are generally considered to impart stability to the composition, thereby allowing the composition to be easily formulated, stored, shipped, and administered.

Suitable antifoaming agents include all materials which are generally useful for this purpose in agrochemical compositions. Suitable antifoaming agents are known in the art and are commercially available. A particularly preferred antifoaming agent is a mixture of polydimethyloxane and perfluoroalkylphosphonic acid, such as a silicone defoamer available from GE or Compton.

Suitable organic solvents are all common organic solvents selected from the group consisting of the active compounds used to completely dissolve them. Again, suitable organic solvents for the active ingredients (A) and (B) are known techniques. The following may be preferred by: N- methylpyrrolidone, N- octyl pyrrolidone, cyclohexyl-1-pyrrolidone; or 200, paraffins, isoparaffins, naphthenic and aromatic hydrocarbons mixture of SOLVESSO ^TM. Suitable solvents are commercially available.

Suitable preservatives include all materials which are generally useful in this type of agrochemical composition and which are also well known in the art. Suitable examples include PREVENTOL ^® (from Bayer AG) and PROXEL ^® (from Bayer AG).

Suitable antioxidants are all materials which are generally used for this purpose in agrochemical compositions, as is known to those skilled in the art. Preferred is butylated hydroxytoluene.

Suitable thickeners include all materials which are generally useful for this purpose in agrochemical compositions. For example, xanthan gum, PVOH, cellulose and its derivatives, clay hydrated citrate, magnesium alumininate or mixtures thereof. Again, such thickeners are known in the art and are commercially available.

The composition may further comprise one or more solid adhesives. Such adhesives are known in the art and are commercially available. These include organic binders, including tackifiers such as substituted cellulose in powder, granules, or lattice versions, cellulose in natural and synthetic polymers, and inorganic binders such as gypsum, cerium oxide or cement.

Furthermore, the composition according to the invention may also contain water, depending on the formulation.

The compositions of the present invention can be used to control insects in the agricultural sector and related fields, including, but not limited to, ants, mites, beetles, butterflies, moths, moths, termites, thrips, weevils, hibiscus. For example, but not limited to:
Ants: Acromyrmex landolti landolti , Atta sexdens rubropilosa ;
Aphids: Aphis gossypii , Brevicoryne brassicae , Macrosiphum euphorbiae , Myzus persicae , Rhopalosiphum graminum ;
Beetle: Anthonomus grandis , Diabrotica speciosa , Diloboderus abderus , Migdolus fryanus , Phyllophaga cuyabana ; Butterfly: Da Nanbai Butterfly ( Ascia monuste orseis );
Moth: Agrotis ipsilon , Alabama argillacea , Anticarsia gemmatalis , Diatraea saccharalis , Epinotia aporema , Helicoverpa armigera , Helicoverpa zea, Heliothis virescens , Leucoptera coffeella , Neoleucinodes elegantalis , Phthorimaea operculella , Plutella xylostella , Pseudaletia adultera , Pseudaletia sequax , Pseudoplusia includens , Rachiplusia nu , Spodoptera cosmioides , and subtropical noctuid ( Spodoptera eridania ), grass worm ( Spodoptera frugiperda );
Cocoon moth: South American corn seedlings ( Elasmopalpus lignosellus );
Termites: Cornitermes bequaerti , Cornitermes cumulans , Neocapritermes opacus , Procornitermes triacifer , Syntermes molestus ;
Hummer : Calihorrips brasiliensis , Frankliniella schultzei ;
Weevil: Eumorphobothrus brasiliensis , Sternechus subsignatus ;
Hibiscus: Porcellio laevis .

The compositions of the present invention are suitable for use in the following crop plants: cereals (wheat, barley, rye, oats, corn, rice, sorghum, triticale, and related crops); beets (such as beets and fodder beets); fruits, such as pears , stone fruit and soft fruit, such as apples, grapes, pears, plums, peaches, almonds, cherries and berries, such as strawberries, raspberries and blackberries; legumes (beans, dried beans, lentils, peas, soybeans); oil plants ( Rape, mustard, sunflower); Cucurbitaceae (cucurbit, cucumber, melon); fiber plants (cotton, flax, hemp, jute); citrus, such as orange, lemon, grapefruit and citrus; vegetables (spinach, lettuce, Asparagus, kale, carrots, onions, tomatoes, potatoes, peppers, broccoli, cucumbers; coffee; sugar cane; trees (eucalyptus) and ornamental plants (flowers such as roses, bushes, broad-leaved trees and evergreens, such as conifers) . In a particular embodiment, the compositions of the invention are applied to cereals, coffee, fiber plants, legumes, oil plants, pasture, sugar cane, trees, and vegetables. In some embodiments, the compositions of the invention are applied to barley, beans, broccoli, kale, coffee, corn, cotton, cucumber, eucalyptus, pasture, potato, rice, soybean, sugar cane, sunflower, tomato, and wheat.

A synergistic composition comprising (A) Nanaide; and (B) Fenpney is particularly effective as described above for barley, beans, broccoli, kale, coffee, corn, cotton, cucumber, eucalyptus, pasture, potato, rice , soybeans, sugar cane, sunflowers, tomatoes, wheat, and the like, and/or environmentally, to avoid, control and/or treat pests.

The rate of application (use) of the compositions of the present invention may vary depending, for example, on the degree of control desired, the type of use, the type of crop, the particular active compound in the combination, the type of plant, but such that the active compound is present in an effective amount The composition is provided to provide the desired effect (eg, insect control). For a particular group of environments, the rate of application of the composition can be readily determined by experimentation. Typically, the compositions of the present invention can be applied at an application rate of between about 0.01 kilograms per hectare (kg/ha) and about 4 kg/ha, in the composition of the active ingredient (component (A) + composition (B) )) The total amount. The application rate is preferably between about 0.05 kg of active ingredient (a.i.)/ha and 2.5 kg a.i./ha.

The compositions of the present invention are useful as insecticides which demonstrate synergistic activity to avoid, control and/or treat pests. The composition can be formulated in the same manner as conventionally formulated insecticides. The compounds can be administered separately or in combination as part of a two part system. The components (A) and (B) can be administered in any desired order, in any combination, continuously or simultaneously. When the components (A) and (B) or the active ingredient are simultaneously administered in the present invention, they may be administered with a composition of the component (A) and (B) or an active ingredient, and In the case, the components (A) and (B) can be obtained from separate preparation sources and mixed together (known as tank mixing, ready-to-use, spray, or slurry), optionally containing other pesticides, or component parts (A). And (B) or the active ingredient may be obtained from a single formulation mixture source (known as premix, concentrate, formula compound (or product)), and optionally mixed with other pesticides.

The compositions of the present invention can be administered in a variety of concentrations in a variety of ways known to those skilled in the art. The composition is useful for application to a desired plant, plant part and/or environment prior to emergence or after emergence to avoid, control and/or manage pests.

The synergistic compositions of the present invention also preferably comprise an agrochemically acceptable carrier for this purpose. In fact, the compound is administered in a formulation containing various adjuvants and carriers known in the art or used to facilitate dispersion. The choice of formulation and the mode of administration of any given compound may affect its activity and will be selected accordingly. Thus the compositions of the invention can be formulated as follows:

Solution (SL), emulsion (EC), water-based emulsion (EW), microemulsion (ME), aqueous suspension (SC), water-dispersible oil suspension (OD), seed treatment suspension (FS), water Dispersible granules (WG), water-soluble granules (SG), wettable powders (WP), water-soluble powders (SP), granules (GR), capsule granules (CG), fine granules (FG) , large granules (GG), concentrated suspoemulsion (SE), capsule suspension (CS), and microgranules (MG), or preferably emulsion (EC), aqueous suspension (SC), water-dispersible granules (WG) or seed treatment suspension (FS).

Using such preparations, whether directly (ie, undiluted) or diluted with a suitable solvent, especially with water, plants, plant parts and/or the environment can be treated and controlled by spraying, pouring, dipping or treating .

The composition can be applied by methods known in the art. These methods include embedding, spraying, dipping, infiltration, injection, irrigation, and the like.

In addition, other biocidal active ingredients or compositions can be combined with the synergistic compositions of the present invention. For example, the composition, in addition to the components (A) and (B), may contain a herbicide, an insecticide, a fungicide, a bactericide, an acaricide or a nematicide to broaden the spectrum of activity. The composition according to the invention is characterized in that it is particularly well tolerated by plants and is environmentally friendly.

As is well known to those skilled in the art, in insect, nematode and fungal tests, many uncontrollable factors can affect the results of individual tests and render them irreproducible. For example, the results may vary depending on environmental factors such as the amount of sunlight and water, the type of soil, the pH of the soil, temperature and humidity, among other factors. Moreover, the depth of planting, the rate of application of individual and combined insecticides and fungicides, as well as the ratio of individual insecticides and fungicides, and the nature of the crop or weed to be tested, can affect the test results. Results between crop varieties may vary from crop to crop.

The following examples are intended to illustrate and not to limit the invention.

Of Example

A. Preparation

a) Water-dispersible granule preparation:
Water-dispersible granules (WG) is by fine grinding of the active parts of the adjuvant composition (by weight 0.5% SUPRALATE ^® (sodium lauryl sulfate, Witco Inc., Greenwich), by weight of 5% REAX ^® 88B (Sodium lignosulfonate, Westvaco Corp.), potassium carbonate (supplemented to 100%)) was blended and then extruded and dried in a jet dryer to prepare.

b) Water suspension:
The aqueous suspension (SC) is obtained by using an extremely finely ground active component with an adjuvant (10% by weight of propylene glycol, 5% by weight of tristyrylphenol ethoxylate, 1% by weight of wood). Sodium sulfonate, 1% by weight of carboxymethylcellulose, 1% by weight of eucalyptus oil (75% by weight of emulsion in water), 0.1% by weight of xanthan gum, Prepared by blending 0.1% by weight of NIPACIDE BIT 20 (Clariant, Asia), water (to make up to 100% by weight).

c) Emulsion:
Emulsion (EC) is prepared by the active parts of the composition with the adjuvant (50g tristyrylphenol ethoxylate, 1g silicone oil, 300g N- methyl-2-pyrrolidone, SOLVESSO ^TM 200 (equilibrated to 1kg) blending .

d) seed treatment suspension

The preparation is prepared according to the above method from the active ingredients of the dosage shown in Table 1 below:
Table 1:
Table 1: EC = emulsion; WG = water-dispersible granules; SC = aqueous suspension; FS = seed treatment suspension.

B. Practical application

Samples 1-11 shown in Table 1 have been tested for effectiveness in the following eight separate examples. The actual application rate of Nanet and/or Fenpney is expressed in grams per hectare (g/ha). The percentage value of the pest is determined by considering the initial population placed on individual plants.

Biological in Example 1 - Cotton - ant (Lu top leaf-cutting ants)

Ants (land-top cutting ants) were raised separately in the laboratory. The number of insects was counted; the insects were collected and placed on healthy cotton young plants, respectively. Individual formulations are diluted and then sprayed onto the plants. After staying in a greenhouse at 21-25 ° C and 80 % relative atmospheric humidity for 10 days, the remaining population was examined. (Table 2)
Table 2:

Biological reality Shi example 2 - potato - aphid ( Taoyuan )

The locusts (taotao) were separately raised in the laboratory. The number of insects was counted, collected, and placed on healthy potato young plants, respectively. The formulation is diluted and then sprayed onto the plants. After staying in a greenhouse at 21-25 ° C and 80% relative atmospheric humidity for 10 days, the remaining population was examined. (table 3)
table 3:

Biological reality Shi example 3 - beans – beetle ( Pesha Leaf armor )

The beetles (the first beetle) were raised separately in the laboratory. The number of insects was counted, collected, and placed on healthy bean seedlings. The formulation is diluted and then sprayed onto the plants. After staying in a greenhouse at 21-25 ° C and 80% relative atmospheric humidity for 10 days, the remaining population was examined. (Table 4)

Biological reality Shi example 4 - coffee – moth ( Coffee leaf miner ) Leucoptera coffeella )

Moth ( Leafoptera coffeella ) was raised separately in the laboratory. The number of insects was counted, collected, and placed on healthy maize young plants, respectively. The formulation is diluted and then sprayed onto the plants. After staying in a greenhouse at 21-25 ° C and 80 % relative atmospheric humidity for 10 days, check the remaining population. (table 5)
table 5:

Biological reality Shi example 5 - corn – Moth ( South American corn seedling )

The moth (South American corn seedlings) were raised separately in the laboratory. The number of insects was counted, collected, and placed on healthy cotton young plants, respectively. The formulation is diluted and then sprayed onto the plants. After staying in a greenhouse at 21-25 ° C and 80 % relative atmospheric humidity for 10 days, the remaining population was examined. (Table 6)
Table 6:

Biological reality Shi example 6 - eucalyptus – termite ( Harassment termite )

Termites (harassment termites) are raised separately in the laboratory. The number of insects was counted, collected, and placed on healthy Eucalyptus young plants, respectively. The formulation is diluted and then sprayed onto the plants. After staying in a greenhouse at 21-25 ° C and 80 % relative atmospheric humidity for 10 days, check the remaining population. (Table 7)
Table 7:

Biological reality Shi example 7 – tomato - Hummer ( Combless flower )

The hummers (combs and flowers) are kept separately in the laboratory. The number of insects was counted, collected, and placed on healthy tomato young plants, respectively. The formulation is diluted and then sprayed onto the plants. After staying in a greenhouse at 21-25 ° C and 80 % relative atmospheric humidity for 10 days, the remaining population was examined. (Table 8)
Table 8:

Biological reality Shi example 8 - cotton – Weevil ( Variant )

Weevils (such as elephant varieties) are housed separately in the laboratory. The number of insects was counted, collected, and placed on healthy cotton young plants, respectively. The formulation is diluted and then sprayed onto the plants. After staying in a greenhouse at 21-25 ° C and 80 % relative atmospheric humidity for 10 days, the remaining population was examined. (Table 9)
Table 9:

Biological reality Shi example 9 - soybean – Hibiscus ( Sliding worm )

Hibiscus (slip worms) are kept separately in the laboratory. The number of insects was counted, collected, and placed on healthy soybean seedlings, respectively. The formulation is diluted and then sprayed onto the plants. After staying in a greenhouse at 21-25 ° C and 80 % relative atmospheric humidity for 10 days, the remaining population was examined. (Table 10)
Table 10:

Biological reality Shi example 10 - rice – termite ( Harassment termite )

Rice seeds are treated with a formulation solution. Seed the seed. After staying in a greenhouse at 15 ° C and 80 % relative atmospheric humidity for 28 days, termites (harassment termites) were reared separately in the laboratory. The number of insects was counted, collected, and placed on healthy young rice plants. After staying in a greenhouse at 21-25 ° C and 80 % relative atmospheric humidity for 10 days, the remaining population was examined. (Table 11)
Table 11

biological real Shi example 11 - sugar cane – termite ( Cocci )

The sugarcane cuttings are treated with a formulation solution. Plant the cuttings. After staying in a greenhouse at 15 ° C and 80 % relative atmospheric humidity for 28 days, termites (cocci) were kept in the laboratory. The number of insects was counted, collected, and placed on healthy young rice plants. After staying in a greenhouse at 21-25 ° C and 80 % relative atmospheric humidity for 10 days, the remaining population was examined. (Table 12)
Table 12

Throughout the specification and the appended claims, unless the context requires otherwise, it is understood that the words "including" and "including" , but does not exclude any other integer or integer group.

The reference to any known art in this specification is not, and should not be construed as,

It will be understood by those skilled in the art that the invention is not limited to the particular application described. The specific elements and/or features described or described in the present invention and the preferred embodiments are not limited thereto. It is to be understood that the invention is not limited to the specific examples disclosed, but can be rearranged, modified and substituted many times without departing from the scope of the invention.

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Claims (13)

A pesticidal composition comprising an effective amount of (A) methamyl and an effective amount of (B) fipronil. The composition of claim 1 wherein the sodium is present in an amount from 1% to about 80% by weight of the composition. The composition of claim 1 wherein the sodium is present in an amount of from about 1% to about 60% by weight based on the weight of the composition. The composition of claim 1 wherein the fentanyl is present at a level of from about 1% to about 80% by weight based on the weight of the composition. The composition of claim 1 wherein the fentanyl is present at a level of from about 1% to about 40% by weight based on the weight of the composition. The composition according to any one of the preceding claims, wherein the ratio of nanode to fenfenib is from 90:1 to 1:90. The composition of claim 6, wherein the ratio is a ratio ranging from 12:1 to 1:1. The composition of claim 6, wherein the ratio is 1:1 or 8:1. The composition of any of the preceding claims, further comprising one or more adjuvants selected from the group consisting of: extenders, carriers, solvents, surfactants, stabilizers, antifoaming agents, antifreeze agents, preservatives , antioxidants, colorants, thickeners, solid adhesives and inert fillers. Use of a composition according to any one of the preceding claims for the prevention, control and/or treatment of pests in the environment of plants, plant parts and/or the like. The use according to claim 10, wherein the worm is selected from the group consisting of an ant, a locust, a beetle, a butterfly, a moth, a moth, a termite, a hummer, a weevil, and a hibiscus. The use according to claim 10 or 11, wherein the environment of the plant, plant part or the like is selected from the group consisting of cereals, coffee, fiber plants, legumes, oil plants, pasture, sugar cane, trees and vegetables. A method for the prevention, control and/or treatment of pests and diseases of a plant part and/or the like, which comprises applying the composition according to any one of claims 1 to 9 to a plant, a plant part and/or the like The environment.