TW201902489A - 核酸寡核苷酸與核苷類似物化學治療劑之協同性組合 - Google Patents

核酸寡核苷酸與核苷類似物化學治療劑之協同性組合 Download PDF

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Publication number
TW201902489A
TW201902489A TW107111859A TW107111859A TW201902489A TW 201902489 A TW201902489 A TW 201902489A TW 107111859 A TW107111859 A TW 107111859A TW 107111859 A TW107111859 A TW 107111859A TW 201902489 A TW201902489 A TW 201902489A
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TW
Taiwan
Prior art keywords
sirna
nucleic acid
madd
cancer
shrna
Prior art date
Application number
TW107111859A
Other languages
English (en)
Chinese (zh)
Inventor
貝勒 帕拉哈卡
希妮 霍普斯
艾帝堤 麥瑟
岳菲
席哈 賽尼
Original Assignee
美商吉瓦納生技公司
伊利諾大學董事會
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 美商吉瓦納生技公司, 伊利諾大學董事會 filed Critical 美商吉瓦納生技公司
Publication of TW201902489A publication Critical patent/TW201902489A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW107111859A 2017-04-24 2018-04-03 核酸寡核苷酸與核苷類似物化學治療劑之協同性組合 TW201902489A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762489061P 2017-04-24 2017-04-24
US62/489,061 2017-04-24

Publications (1)

Publication Number Publication Date
TW201902489A true TW201902489A (zh) 2019-01-16

Family

ID=63919871

Family Applications (1)

Application Number Title Priority Date Filing Date
TW107111859A TW201902489A (zh) 2017-04-24 2018-04-03 核酸寡核苷酸與核苷類似物化學治療劑之協同性組合

Country Status (3)

Country Link
AR (1) AR111408A1 (fr)
TW (1) TW201902489A (fr)
WO (1) WO2018200145A1 (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007084954A2 (fr) * 2006-01-19 2007-07-26 The Board Of Trustees Of The University Of Illinois Inhibition sélective des variantes d'épissure de l'ig20 pour traiter le cancer

Also Published As

Publication number Publication date
AR111408A1 (es) 2019-07-10
WO2018200145A1 (fr) 2018-11-01

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