TW201815375A - Sustained release structure for skin whitening and oxygen supply - Google Patents

Abstract

The invention provides a gaseous skin oxygen supply and whitening product. The product comprises a solid oxygen source, an activating agent and a catalyst, wherein the solid oxygen source adopts one of peroxide and percarbonate. The invention further provides applications of the gaseous skin oxygen supply and whitening product. The whitening product is wrapped by a breathable container during application, wherein the breathable container is one of the gauze mask, the face guard, the facial mask, the bra, the breast patches, the milk spilling-preventing patches, the sanitary towel, the paper diaper, the sanitary pad, the disposable sanitary product, the band-aid, the binding gauze and the box-shaped container.

Description

   Oxygen supply material with skin whitening function   

The invention relates to a gaseous skin oxygen supply and whitening product and its application, and belongs to the technical field of medical cosmetology.

The existence of human skin melanin is mainly to combat the damage caused by ultraviolet rays to the skin, but in terms of modern aesthetics, melanin also causes great distress to many people. For example: freckles, age spots, melasma, sweat spots, areola pigmentation darkened, melanin precipitation in private places.

There are many factors that cause melanin precipitation in the skin, including genetic factors, skin aging, skin hypoxia, excessive friction, sequelae of hormone-containing topical drugs, pregnancy, and estrogen secretion.

Melanocytes produce melanin, which mainly occurs in the stratum basal layer of the skin epidermis. With metabolism, it gradually pushes to the stratum corneum, the granular layer, the transparent layer, and the stratum corneum, which is finally transported to the outermost layer of the epidermis.

The whitening products on the market are all liquid, paste, and emulsion. It is very difficult to reach the basal layer of the epidermis because the molecular weight is too large. This is the main reason why the whitening effect is not good. The current method of removing melanin also includes surgical methods. Laser is used to remove melanin, but there are certain risks. If the laser hits the dermis, it will easily cause permanent trauma to the skin.

In order to solve the shortcomings of the prior art, the present invention provides a gaseous skin oxygenation and whitening product with good whitening effect and safety, which has become an important subject to be solved by the present invention.

The present invention provides a gaseous skin oxygenation and whitening product with good whitening effect and safety. The product can react with moisture in body fluids such as sweat secreted by the human body to generate oxygen and active oxygen. In addition to providing oxygen required for healthy skin breathing, skin whitening while providing a gas reactive oxygen species, including hydrogen superoxide (HOO ^-), superoxide anions, hydroperoxy radicals (. HOO), since the active oxygen is very small molecular weight, the diameter is about 1nm, and therefore can The skin voids in the epidermal layer (epidermal skin void diameter is 200nm ~ 80,000nm) reach the basal layer of the skin and interact with melanin, making the melanin lighter or even transparent.

In order to solve the above technical problems, an object of the present invention is to provide an oxygen supply material with skin whitening function. The oxygen supply material with skin whitening function includes a solid oxygen source, an activator, and a catalyst. The solid oxygen source is selected from the group consisting of A group of peroxides and percarbonates.

To achieve the foregoing object of the present invention, the activator is a fluorenyl compound.

To achieve the foregoing object, the peroxide is selected from the group consisting of calcium peroxide, magnesium peroxide, sodium peroxide, potassium peroxide, sodium percarbonate, and calcium percarbonate.

In order to achieve the foregoing object of the present invention, the fluorenyl compound is selected from the group consisting of tetraethylammonium ethylenediamine (TAED), sodium nonyloxybenzenesulfonate (NOBS), tetraethylammonium glycoluril, pentaethylammonium glucose, N -A group consisting of ethyl acetophthalimide, 1-ethyl acetoethyl benzoate, triethyl acetoethanolamine, and nonyl acetophenone sulfonate.

In order to achieve the aforementioned object, the catalyst is catalase.

To achieve the foregoing object of the invention, the mass ratio of the activator to the solid oxygen source is 0.5: 100 to 10: 100; and the mass ratio of the catalyst to the solid oxygen source is 0.5: 100 to 5: 100.

To achieve the foregoing object of the invention, the preferred mass ratio of the activator to the solid oxygen source is 2: 100 ~ 3: 100; and the preferred mass ratio of the catalyst to the solid oxygen source is 1.5: 100 ~ 2.5: 100.

In order to achieve the foregoing object of the invention, the oxygen-supplying material having skin-whitening function may further be added with citric acid, and the mass ratio of the solid oxygen source of the citric acid is 5-8: 2-5.

In order to achieve the foregoing object of the invention, the particle size of the oxygen-supplying material having a skin-whitening function is 2000 mesh-2 mm.

In order to achieve the aforementioned object of the invention, the oxygen-supplying material with skin-whitening function can be placed in sanitary products. The sanitary products include masks, face masks, masks, bras, chest stickers, breast milk stickers, sanitary napkins, diapers, sanitary care Pads, disposable sanitary products, band-aids, bandaged gauze, box-type containers.

Another object of the present invention is to provide a skin-whitening structure that supplies oxygen. The whitening structure is a material that wraps the oxygen-supplying material with skin-whitening function as described in claims 1 to 10 of the patent application range. The particle diameter of the functional oxygen-supplying material is 2000 mesh-2mm, wherein the breathable material has small holes that allow gas to pass through, and the diameter of the small holes is smaller than the particle diameter of the oxygen-supplying material with skin whitening function.

1‧‧‧ core

2‧‧‧ inner layer

3‧‧‧ Outer

4‧‧‧function unit

5‧‧‧ Outer coating

Figure 1 is a schematic diagram of the structure of an oxygen-supplying material with skin-whitening function that has sustained-release active oxygen and oxygen.

Figure 2 is a schematic diagram of the structure of the functional unit on the inner surface of the inner core; Figure 3 is a schematic diagram of the structure of the functional unit on the outer surface of the inner core; Figure 4 is a schematic diagram of the structure of the functional unit between the inner cores;

The present invention is exemplified by the following examples, but the present invention is not limited by the following examples.

As shown in Fig. 1, Fig. 2, and Fig. 3, a structure of an oxygen-supplying material with skin-whitening function with sustained-release active oxygen and oxygen includes an inner core 1 and an outer covering layer 5, and the inner core 1 is used for fixing the skin. Functional unit 4 of oxygen-supplying material with whitening function, the inner core 1 is a water-absorbing material, and the outer covering layer 5 is used to cover the inner core 1; the functional units 4 can be evenly distributed on the inner surface of the inner core 1, and the functional units 4 can be uniform Distributed on the outer surface of the inner core 1, the functional units 4 may be evenly distributed between the inner cores 1. The outer covering layer 5 includes an inner layer 2 and an outer layer 3. The inner layer 2 is a breathable structure of a skin-friendly material, and the outer layer 3 may be a breathable material and an air-impermeable material. In order to make the effect of slow release active oxygen and oxygen better, it is preferred Yes, the outer layer 3 is made of airtight material. The functional unit 4 is a mixture of a solid oxygen source, a catalyst, and an activator.

Formula combination of oxygen supply material with skin whitening function

An oxygen-supplying material with skin-whitening function, which is composed of solid oxygen source of calcium peroxide, catalyst catalase, and activator tetraethylammonium ethylenediamine, which is a whitening formula 1; wherein the catalase and calcium peroxide The mass ratio is 1: 200; wherein the mass ratio of the tetraethylammonium ethylenediamine to calcium peroxide is 1: 200; wherein the oxygen-supplying material with skin whitening function has a particle size of 60 mesh.

The solid oxygen source of calcium peroxide (CaO ₂ ) is uniformly mixed with the catalyst catalase (CAT) and the activator tetraethyl ethylenediamine (TAED), and the water (sweat) or body fluid (urine) discharged from the skin is used. Or blood), or use the moisture (humidity) in the air with the above-mentioned oxygen-supplying material with skin-whitening function, or use an additional aqueous liquid with the oxygen-supplying material with skin-whitening function when in use.

Its reaction formula is CaO ₂ + H ₂ O → Ca (OH) ₂ + O ₂ ; the hydrogen peroxide (H ₂ O ₂ ), which is an intermediate product of the above reaction, dissociates into anion of hydrogen peroxide in a basic medium like a weak acid.

^{_{H 2 O 2 + OH - →}} HOO - + H 2 O

Hydrogen peroxide is a nucleophile anion, hydrogen peroxide initiator having a radical-forming ^{_{effect; HOO - + H 2 O 2}} → HOO. + HO. + OH ^-

Both have high activity, which can oxidize and decompose the pigment and produce bleaching effect.

The generated gaseous active oxygen can maintain a high active oxygen gas concentration in a coated environment.

Whitening formula 2: It is a mixture of solid oxygen source calcium peroxide, catalyst catalase, and activator tetraethylamidylethylenediamine. Based on whitening formula 1, the addition amount of catalyst and activator is changed. The mass ratio of catalase to calcium peroxide is 1:50; wherein the mass ratio of the tetraethylfluorenylethylenediamine to calcium peroxide is 1:40.

Whitening formula 3: It is a mixture of solid oxygen source calcium peroxide, catalyst catalase, and activator tetraethylamidylethylenediamine. Based on the whitening formula 1, the addition amount of catalyst and activator is changed. The mass ratio of the catalase to calcium peroxide is 1:20; wherein the mass ratio of the tetraethylfluorenylethylenediamine to calcium peroxide is 1:10.

Whitening formula 4: It is a mixture of solid oxygen source calcium peroxide, catalyst catalase, activator tetraethylammonium ethylenediamine and citric acid. On the basis of whitening formula 2, citric acid is added. The mass ratio of catalase to calcium peroxide is 1:50; wherein the mass ratio of the tetraethylfluorenylethylenediamine to calcium peroxide is 1:40; wherein the mass ratio of the citric acid to calcium peroxide is 7: 4.

Whitening Formula 5: On the basis of Whitening Formula 2, change the type and particle size of the solid oxygen source and activator, where the solid oxygen source is magnesium peroxide; where the activator is sodium nonyloxybenzenesulfonate; The particle size of the product is 2000 mesh.

Whitening formula 6: On the basis of whitening formula 2, the types of solid oxygen source and activator are changed, wherein the solid oxygen source is sodium peroxide; and the activator is tetraethylpyrrolidin.

Whitening formula 7: On the basis of whitening formula 2, the type of solid oxygen source and activator and the particle size of the product are changed, wherein the solid oxygen source is potassium peroxide; wherein the activator is pentaethoxyglucose; where the product granule The diameter is 2mm.

Whitening formula 8: On the basis of whitening formula 2, the types of solid oxygen source and activator are changed, wherein the solid oxygen source is sodium percarbonate; and the activator is N-ethylfluorenylphthalimide.

Whitening formula 9: Based on whitening formula 2, the type of solid oxygen source and activator is changed, wherein the solid oxygen source is calcium percarbonate; wherein the activator is 1-acetamidine ethyl benzoate.

Whitening formula 10: On the basis of whitening formula 2, the type of activator is changed, wherein the activator is triethylamidoethanolamine.

Whitening formula 11: On the basis of whitening formula 2, the type of activator is changed, wherein the activator is acenaphthyl sulfonate.

Control group 1: It is a mixture of solid oxygen source calcium peroxide, catalyst catalase, and activator tetraethylamidylethylenediamine. Based on whitening formula 1, the addition amount of catalyst and activator is changed. The mass ratio of the catalase to calcium peroxide is 1: 250; wherein the mass ratio of the tetraethylfluorenylethylenediamine to calcium peroxide is 11: 100

Control group 2: It is a mixture of solid oxygen source calcium peroxide, catalyst catalase, and activator tetraethylenylethylenediamine. Based on the whitening formula 1, the addition amount of catalyst and activator is changed. The mass ratio of the catalase to calcium peroxide is 5.5: 100; wherein the mass ratio of the tetraethylfluorenylethylenediamine to calcium peroxide is 1: 250.

Control group 3: It is a mixture of solid oxygen source calcium peroxide and catalyst catalase. Based on the whitening formula 2, the tetraethylammonium ethylenediamine is removed. The catalase occupies the quality of calcium peroxide. The percentage is 2%.

Control group 4: Only solid oxygen source of calcium peroxide was used.

Example 1 Application of an oxygen-supplying material with skin whitening function to sanitary napkins

The sanitary napkin includes an inner core and an outer covering layer. The inner core is used to fix functional components. The functional components can be evenly distributed on the inner surface of the inner core, or can be evenly distributed on the outer surface of the inner core 1, or can be evenly distributed on the inner core 1. Between the inner cores.

The outer cladding layer includes an inner layer and an outer layer. The inner layer is a skin-friendly breathable structure. The outer layer can be a breathable material and a non-breathable material. In order to make the effect of slow release of active oxygen and oxygen better, it is preferable that the outer layer is Breathable material, other preparation processes use existing technology.

Among them, the functional ingredients are prepared by using the powders described in the whitening formula 1-4 and the control group 1-2 into different types of sanitary napkins; the functional ingredient is added in an amount of 1-1.2 g / tablet.

Experimental method: Recruit 600 volunteers to try out the sanitary napkins of the present invention and the comparative example. The volunteers use the sanitary napkins 24 hours a day (negligible for short-term bathing, etc.). After using for 2 months, fill in the evaluation questionnaire independently. Volunteers were aged 35-50 years old and were divided into 6 groups on average: Efficacy Evaluation: Ineffective: No significant change in skin color in private parts; Effective: Skin melanin deposition in private parts was reduced by less than 50%, and the area of melanin deposition was reduced by 30% The following: skin is smooth and elastic, and the odor is reduced; it is very effective: the skin color of private parts is obviously lighter, the degree of melanin deposition is reduced by more than 50%, and the area of melanin is reduced by more than 30%; the skin is smooth and elastic, and basically has no odor.

Embodiment 2 Application of an oxygen-supplying material with skin-whitening function to a chest patch The chest patch includes an inner core and an outer covering layer, the inner core is used for fixing functional components, and the functional components can be evenly distributed on the inner surface of the inner core. It can also be uniformly distributed on the outer surface of the inner core 1, or can be uniformly distributed between the inner cores.

The outer cladding layer includes an inner layer and an outer layer. The inner layer is a skin-friendly breathable structure. The outer layer can be a breathable material and a non-breathable material. In order to make the effect of slow release of active oxygen and oxygen better, it is preferable that the outer layer is Breathable material, other preparation processes use existing technology.

Wherein, the functional ingredients are prepared by using the powders described in the whitening formula 1-4 and the control group 1-2 to prepare different types of chest patches; the added amount of the functional ingredients is 0.3-0.5 g / tablet.

Experimental method: 600 female volunteers were recruited to try the present invention and the comparative chest patch. 600 women had pregnancy experience with areola and black hair; volunteers used the patch 24 hours a day (short time Bathing, etc. is negligible), after 15 days of use, fill in the assessment questionnaire independently. Volunteers are 30-45 years old and divided into 6 groups on average.

Effect evaluation: Ineffective: There are no obvious changes in the color of the areola and the nipple skin; Effective: The diameter of the areola is reduced by less than 30%; the color of the areola is lightened by 50% or less; the color of the top of the nipple is lightened by 50% or less; the color of the side of the nipple is lightened by less than 15%; Very effective: the diameter of the areola is reduced by more than 30%; the color of the areola is lightened by more than 50%; the color of the top of the nipple is lightened by more than 50%; the color of the side of the nipple is lightened by more than 15%; the color of the areola and the top of the nipple is pink (Female color is that color)     

Example 3 Application of an oxygen-supplying material with skin whitening function to a mask

The mask includes an inner core and an outer cladding layer. The inner core is used to fix functional components. The functional components can be evenly distributed on the inner surface of the inner core, and can be evenly distributed on the outer surface of the inner core 1. Between the cores.

The outer cladding layer includes an inner layer and an outer layer. The inner layer is a skin-friendly breathable structure. The outer layer can be a breathable material and a non-breathable material. In order to make the effect of slow release of active oxygen and oxygen better, it is preferable that the outer layer is Breathable material, other preparation processes use existing technology.

Wherein, the functional ingredients are prepared by using the powders described in the whitening formula 1-4 and the control group 1-2 to prepare different types of masks; the added amount of the functional ingredients is 0.6-0.8 g / tablet.

Experimental method: 150 female volunteers were recruited and divided into 6 groups on average. The masks of the present invention and the comparative examples were tried. The volunteers were 70-80 years old, and all 150 women had severe age spots.

Volunteers use the mask 24 hours a day (negligible for short baths, meals, etc.). After using the mask for 15 days, they fill in the assessment questionnaires independently.

Evaluation:

Ineffective: there is no significant change in the area and color of senile plaques

Effective: The color of age spots becomes lighter than 50%; the area is reduced by less than 30%; Very effective: the color of age spots becomes lighter by more than 50% and the area is reduced by more than 30%;

From the results in Table 3, it can be seen that the intervention of the activator tetraethylamidylenediamine (TAED) can obtain more active oxygen HO ₂ ^- in a normal temperature environment, and obtain a better whitening effect.

Example 4 Application of an oxygen supply material with skin whitening function in a medical dressing

When the skin is traumatized, the skin is damaged due to external forces at the wound and the dermis is damaged. The destruction of microvessels directly affects the ability of the blood to supply oxygen to the wound. At this time, the healing of the skin is prolonged due to hypoxia, and at the same time, The wound healing process may also be accompanied by the precipitation of melanin to form stains and even cause anaerobic infection.

The oxygen-generating formula according to the whitening formula 2 of the present invention is placed in the interlayer of a medical dressing (a band-aid, a non-woven fabric for bandaging) to provide wound oxygen to help wound healing, and at the same time, it can prevent the accumulation of melanin on the skin to form pigment classes, and it can also suppress anorexia Propagation and infection of aerobic bacteria.

The above-mentioned oxygen-supplying material with skin-whitening function is covered with a breathable container during application. The breathable container is a breathable mesh fabric structure. On the one hand, it provides an active oxygen source for the covered skin and can also load the whitening agent according to the present invention. The product is in a sandwich, and a tiny space is formed between the breathable mesh fabric structure and the skin, and the powder does not directly contact the skin. The breathable container is one of a mask, a face mask, a mask, a bra, a breast stick, a breast pad, a sanitary napkin, a diaper, a sanitary pad, a disposable sanitary product, a band-aid, a bandage gauze, and a box-shaped container. When the product of the present invention uses a box-shaped container as a carrier, the powder can be placed in the box and sealed with a breathable material (non-woven fabric, gauze). The powder is loaded in the sandwich of the coating container to isolate the powder from the skin. A tiny space is formed between the outer layer of the structure and the skin to facilitate storage of active oxygen and maintain an appropriate concentration, and to continuously provide gaseous whitening active oxygen to the skin.

The oxygen-supplying material with skin-whitening function is in the form of granules or powder or the powder is compressed into one body; the particle size of the product is 2000 mesh-2mm; . The particle size of the oxygen-supplying material with skin whitening function is preferably 40-80 mesh; the particle size of the oxygen-supplying material with skin whitening function is more preferably 60 mesh.

When the above-mentioned oxygen-supplying material with skin-whitening function is used in a breathable container other than adult diapers, the usage amount is 0.3-2g / piece; when the above-mentioned oxygen-supplying material with skin-whitening function is used in adult diapers, the amount is large. It is 1-10g.

Compared with the prior art, the beneficial effects of the present invention are as follows:

(1) The oxygen-supplying material with skin-whitening function according to the present invention, applied in sanitary napkins, can whiten the skin of women's private parts, and the melanin deposits in private parts of the skin are significantly reduced, and the area of melanin deposits is reduced. Elasticity and odor reduction; total effective rate is 94-100%; (2) the oxygen-supplying material with skin-whitening function according to the present invention, applied in chest stickers, has the effect of whitening the skin of the chest, the color of areola and nipples Significantly lighter, from dark brown to flesh pink; total effective rate is 94-99%; (3) the application of the oxygen supply material with skin whitening function according to the present invention in a face mask, the area of senile plaques is significantly reduced, The color is obviously lightened, and the total effective rate is 93-100%; (4) The oxygen supply material with skin whitening function according to the present invention is applied in a medical dressing (a band-aid, a non-woven fabric for bandaging) to provide a wound Oxygen helps wounds heal, and at the same time prevents the accumulation of melanin in the skin to form pigment classes, and it can also inhibit the reproduction and infection of anaerobic bacteria.

The above detailed description is a specific description of the feasible embodiment of the present invention, but this embodiment is not intended to limit the patent scope of the present invention. Any equivalent implementation or change that does not depart from the technical spirit of the present invention should be included in this case. Within the scope of patents.

The above-mentioned multiple effects are really in line with the statutory patent requirements of novelty and advancement. You have submitted an application in accordance with the law, and kindly ask your office to approve this invention patent application to encourage invention.

Claims (11)

    An oxygen supply material with skin whitening function, the oxygen supply material includes a solid oxygen source, an activator, and a catalyst; wherein the solid oxygen source is selected from the group consisting of a peroxide and a percarbonate.         The oxygen-supplying material with skin-whitening function according to item 1 of the scope of patent application, wherein the activator is a fluorenyl compound.         The oxygen-supplying material with skin whitening function according to item 1 of the scope of patent application, wherein the peroxide is selected from the group consisting of calcium peroxide, magnesium peroxide, sodium peroxide, potassium peroxide, sodium percarbonate, and peroxide. A group of calcium carbonate.         The oxygen-supplying material with skin-whitening function according to item 2 of the scope of the patent application, wherein the fluorenyl compound is selected from the group consisting of tetraethylfluorinated ethylenediamine (TAED), sodium nonyloxybenzenesulfonate (NOBS ), Tetraethylpyridine, Pentaethylpyridine Glucose, N-Ethylpyrexylimine, 1-Ethylethylbenzoate, Triethylethynylethanolamine, and Nonylacetophenone Sulfonate Group of acid salts.         The oxygen-supplying material with skin-whitening function according to item 1 of the scope of the patent application, wherein the catalyst is catalase.         The oxygen-supplying material with skin whitening function as described in item 1 of the scope of patent application, wherein the mass ratio of the activator to the solid oxygen source is 0.5: 100 ~ 10: 100; wherein the mass of the catalyst and the solid oxygen source The ratio is 0.5: 100 ~ 5: 100.         The oxygen-supplying material with skin whitening function according to item 1 of the scope of the patent application, wherein the preferred mass ratio of the activator to the solid oxygen source is 2: 100 ~ 3: 100; wherein the catalyst and the solid oxygen source are The preferred mass ratio is 1.5: 100 ~ 2.5: 100.         The oxygen-supplying material with skin-whitening function according to item 1 of the scope of the patent application, wherein the oxygen-supplying material with skin-whitening function can further be added with citric acid, wherein the mass ratio of the solid oxygen source of the citric acid is 5-8 : 2 ~ 5.         The oxygen-supplying material with skin-whitening function according to item 1 of the scope of the patent application, wherein the oxygen-supplying material with skin-whitening function is granular, powdery, or powder compacted into one body, and the The particle size of the oxygen supply material is 2000 mesh-2mm.         According to the oxygen supply material with skin whitening function described in item 1 of the scope of the patent application, the oxygen supply material with skin whitening function can be placed in sanitary products, which include masks, masks, masks, bras, Chest stickers, breast milk stickers, sanitary napkins, diapers, sanitary pads, disposable sanitary products, band-aids, bandaged gauze, box-type containers.         An oxygen-supplying material structure with skin-whitening function. The whitening structure is a breathable material that wraps the oxygen-supplying material with skin-whitening function as described in claims 1 to 10 of the patent application scope. The oxygen-supplying material with skin-whitening function The particle diameter is 2000 mesh-2mm, wherein the breathable material has small holes through which gas can pass, and the diameter of the small holes is smaller than the particle diameter of the oxygen supply material with skin whitening function.