TW201800087A - Oral composition - Google Patents

Abstract

An oral composition is provided in the present invention. The oral composition contains scutellaria root, cinnamon bark and poria sclerotium. In the oral composition, when an amount of the scutellaria root is defined as XA [mass%] and an amount of the cinnamon bark is defined as XB [mass%], it is preferred that the following relation is satisfied: 0.00005 ≤ XB/XA ≤ 20000. In the oral composition, when the amount of the scutellaria root is defined as XA [mass%] and an amount of the poria sclerotium is defined as XC [mass%], it is preferred that the following relation is satisfied: 0.000025 ≤ XC/XA ≤ 40000. This makes it possible to obtain the oral composition containing a plurality of crude drugs and having a bad breath prevention effect which is obtained at a lower amount of the crude drugs than that of a single crude drug.

Description

Oral composition

The present invention relates to an oral composition.

The composition for the oral cavity includes various oral compositions in which an oral composition that physically removes dirt adhering to teeth is added to an oral composition in which various pharmacological effects are desired and a medicinal component is formulated.

In particular, an oral composition containing a plant component (especially a long-lived crude drug component) which is a component derived from a natural substance has physiological activity and is thus safer than a component derived from a non-natural substance. The aspect is more excellent, so it is especially needed in the technical field. (Refer to Patent Documents 1 to 3).

In recent years, it has been demanded for the oral composition to further improve the prevention of bad breath.

[Previous Technical Literature]

[Patent Literature]

Patent Document 1: Japanese Patent Laid-Open Publication No. 2015-54847.

Patent Document 2: Japanese Patent Laid-Open No. Hei 6-25000.

Patent Document 3: Japanese Laid-Open Patent Publication No. 2011-256136.

An object of the present invention is to provide an oral composition having the effect of preventing bad breath, which is formulated with a plurality of crude medicines, and which can be obtained in a low dose compared with the use of a separate crude drug.

Such an object can be achieved by the present invention of the following (1) to (5).

(1) An oral composition comprising scutellaria, cinnamon and medlar.

(2) The oral composition according to the above (1), wherein the content of the scutellaria in the oral composition is X _A [% by mass], and the cassia of the oral composition is When the content ratio is set to X _B [% by mass], the relationship of 0.00005 ≦ X _B / X _A ≦ 20000 is satisfied.

(3) The oral composition according to the above (1) or (2), wherein the content of the scutellaria in the oral composition is X _A [% by mass], and the oral composition is When the content ratio of the above enthalpy is X _C [% by mass], the relationship of 0.000025 ≦ X _C /X _A ≦40000 is satisfied.

The oral composition according to any one of the above aspects of the present invention, wherein the content of the cinnamon in the oral composition is X _B [% by mass], and the oral cavity is When the content ratio of the above ruthenium in the composition is X _C [% by mass], the relationship of 0.000025 ≦ X _C / X _B ≦ 40000 is satisfied.

(5) The oral composition according to any one of (1) to (4) above, comprising at least one of the yellow scorpion, the cinnamon, and the sputum as an extract.

According to the present invention, it is possible to provide an oral composition having the effect of preventing bad breath, which is formulated with a plurality of crude medicines, and which can be obtained in a low dose compared with the use of a separate crude drug.

Hereinafter, preferred embodiments of the present invention will be described in detail.

Oral Composition

The composition for the oral cavity includes various oral compositions in which an oral composition that physically removes dirt adhering to teeth is added to an oral composition in which various pharmacological effects are desired and a medicinal component is formulated.

In particular, it contains plant ingredients that are derived from natural substances (especially The oral composition having a long history of the crude drug component has physiological activity and is more excellent in safety than the component derived from the non-natural substance, and thus is particularly demanded in the technical field.

In recent years, it has been demanded for the oral composition to further improve the prevention of bad breath.

Therefore, the present inventors conducted intensive studies, and as a result, it has been found that by using a combination of a variety of crude drugs, such as scutellaria, cinnamon, and sputum in an oral composition, these effects can be multiplied to obtain an excellent effect.

That is, the oral composition of the present invention contains xanthine, cinnamon and medlar. Excellent anti-maste odor can be obtained by containing jaundice, cinnamon and medlar. In particular, even in the case where a lower content rate of efficacy is not obtained at the time of using a separate crude drug, a sufficiently excellent preventive effect against bad breath can be obtained.

Further, the above documents have been described for various crude drugs, but there is no specific disclosure regarding the combination of oral compositions of scutellaria, cinnamon and medlar.

In the present invention, the composition for oral cavity may, for example, be pulverized in a dry state to directly contain xanthine, cinnamon, and sputum, or may be extracted as an extraction medium such as an extraction solvent such as water or an organic solvent or an extraction medium such as a supercritical fluid. Or a component obtained by removing an extraction medium from the extracting component (hereinafter, these are collectively referred to as an extract).

In particular, it is preferred that the oral composition contains at least one of astragalus, cinnamon, and medlar as an extract, and more preferably contains all of astragalus, cinnamon, and medlar as extracts.

Thereby, quality unevenness between manufacturing lots can be suppressed, and stable quality can be obtained.

Further, the oral composition can contain a preferred component among the components derived from the natural substance at a high content, and can suppress the content of the less desirable component to be low. As a result, for example, it is possible to prevent a decrease in color tone, flavor, and the like of the oral composition, and it is possible to more reliably exhibit the desired effect. Further, more excellent stability of the active ingredient in the oral composition can be obtained. Therefore, the storage stability of the entire composition for the oral cavity is improved, and the lifespan of the composition for oral cavity can be further extended, and the preservation conditions can be alleviated.

As the extraction solvent for obtaining the extract of scutellaria, cinnamon and medlar, for example, various inorganic solvents and various organic solvents can be used. More specifically, water; methanol, ethanol, propanol, isopropanol, butanol, isobutanol, octanol, phenol, etc. monohydric alcohol; propylene glycol, 1,3-butanediol, 1,2- Butylene glycol, 1,4-butanediol, 1,5-pentanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5- Polyols such as pentatriol, glycerin, polyethylene glycol (molecular weight 1 million to 100,000); ketones such as acetone and methyl ethyl ketone; esters such as ethyl acetate and methyl acetate; diethyl ether and dimethyl ether Ethyl methyl ether, Ethers such as dioxane; nitriles such as acetonitrile; halides such as chloroform and carbon tetrachloride; aliphatic hydrocarbons such as hexane, octane and cyclohexane; aromatic hydrocarbons such as xylene, toluene and benzene, etc. One or more selected from the group consisting of these are used. Further, as the extraction solvent, an acid (for example, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, or the like) or a base (for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, or the like) may be used.

Among them, as the extraction solvent for obtaining the extract of Astragalus, an aqueous ethanol solution is preferably used.

Thereby, the aforementioned effects can be exerted more significantly.

In particular, the concentration (ethanol content) of the aqueous ethanol solution for obtaining the extraction solvent of the extract of Astragalus membranaceus is preferably 30% by volume or more and 95% by volume or less, more preferably 40% by volume or more and 70% by volume or less.

Thereby, the aforementioned effects can be further exerted remarkably.

Further, as the extraction solvent for obtaining the extract of cinnamon, a solvent containing water is preferred.

Thereby, the aforementioned effects can be exerted more significantly.

In particular, the content of water contained in the extraction solvent for obtaining the extract of cinnamon is preferably 90% by mass or more, and more preferably 95% by mass or more.

Thereby, the aforementioned effects can be further exerted remarkably.

Further, as the extraction solvent for obtaining the extract of hydrazine, an aqueous ethanol solution is preferably used.

Thereby, the aforementioned effects can be exerted more significantly.

In particular, the concentration (ethanol content) of the aqueous ethanol solution for obtaining the extraction solvent of the extract of cerium is preferably 30% by volume or more and 95% by volume or less, more preferably 45% by volume or more and 85% by volume or less.

Thereby, the aforementioned effects can be further exerted remarkably.

The composition for oral cavity may contain xanthine, cinnamon, and barium in any form, and may be contained, for example, in the form of a powder or a granule, or may be contained as an oily component, or may be contained in a state of being dissolved in other components.

The content of the scutellaria in the composition for oral cavity (the content of jaundice in a dry state) is not particularly limited, but is preferably 0.00001% by mass or more and 10% by mass or less, more preferably 0.0001% by mass or more and 2.0% by mass or less, and further Preferably, it is 0.0005 mass% or more and 0.05 mass% or less.

When the content of the scutellaria is not more than the above-described lower limit, there is a possibility that the effects produced by the present invention are not sufficiently exhibited depending on the content of the cassia and the sputum.

In addition, if the content of the scutellaria is more than the above-mentioned upper limit, there is a problem that coloration occurs more remarkably, or a feeling of use due to an odor such as bitterness or the like The situation of lowering the problem.

The content of the cinnamon in the composition for oral cavity (the content of the cinnamon in the dry state) is not particularly limited, but is preferably 0.00001% by mass or more and 10% by mass or less, more preferably 0.0001% by mass or more and 2.0% by mass or less, and further Preferably, it is 0.0008 mass% or more and 0.1 mass% or less.

When the content rate of the cassia is less than the above-mentioned lower limit, the effect of the present invention may not be sufficiently exhibited depending on the content of the scutellaria and the sputum.

In addition, when the content of the cassia is more than the above-mentioned upper limit, there is a problem that the coloring problem occurs more remarkably, or the sensation of use such as bitterness or the like is lowered.

The content of the mash in the oral composition (the content of the mash in the dry state) is not particularly limited, but is preferably 0.00001% by mass or more and 10% by mass or less, more preferably 0.00005% by mass or more and 4.0% by mass or less, and further It is preferably 0.002% by mass or more and 1.0% by mass or less.

When the content of the cockroach is less than the above-mentioned lower limit, the effect of the present invention may not be sufficiently exhibited depending on the content of scutellaria and cinnamon.

In addition, when the content of the cerium exceeds the above-mentioned upper limit, there is a problem that the coloring problem occurs more remarkably, or the sensation of use such as bitterness or the like is lowered.

When the content of xanthine in the oral composition is X _A [% by mass] and the content of cinnamon in the oral composition is X _B [% by mass], it is preferable to satisfy 0.00005 ≦ X _B / The relationship of X _A ≦ 20000 is more preferably a relationship of 0.015 ≦ X _B / X _A ≦ 200, and further preferably a relationship of 0.03 ≦ X _B / X _A ≦ 100.

Thereby, it is possible to obtain a more excellent effect of preventing bad breath, and at the same time, it is possible to obtain more excellent storage stability of the oral composition and the like.

When the content of xanthine in the oral composition is X _A [% by mass] and the content of cerium in the oral composition is X _C [% by mass], it is preferably 0.000025 ≦ X _C / The relationship of X _A ≦40000 is more preferably to satisfy the relationship of 0.04 ≦X _C /X _A ≦2000, and further preferably to satisfy the relationship of 0.1 ≦X _C /X _A ≦1000.

Thereby, it is possible to obtain a more excellent effect of preventing bad breath, and at the same time, it is possible to obtain more excellent storage stability of the oral composition and the like.

When the content of the cinnamon in the oral composition is X _B [% by mass] and the content of the enamel in the oral composition is X _C [% by mass], it is preferably 0.000025 ≦ X _C / The relationship of X _B ≦40000 is more preferably to satisfy the relationship of 0.02 ≦X _C /X _B ≦1250, and further preferably to satisfy the relationship of 0.05 ≦X _C /X _B ≦700.

Thereby, it is possible to obtain a more excellent effect of preventing bad breath, and at the same time, it is possible to obtain more excellent storage stability of the oral composition and the like.

The composition for oral cavity of the present invention may contain components other than the above.

Examples of such a component (other component) include an abrasive, a wetting agent, a solvent, a binder, a fragrance, an excipient, a sweetener, a pH adjuster, a preservative, an emulsifier, a cosolvent, and a foaming agent. Agents, lubricants, oils, surfactants, colorants, antioxidants, chelating agents, flavoring agents, moisturizers, antibacterial agents, anti-inflammatory agents, fluorides, vitamins, crude drugs other than the foregoing.

Examples of the polishing agent include cerium oxide-based abrasives such as tannin extract, precipitated cerium oxide, cerium cerium oxide, aqueous citric acid, anhydrous citric acid, aluminosilicate, and zirconium silicate; and hydrogen phosphate dihydrate. Calcium hydrogen phosphate such as calcium and anhydrous calcium hydrogen phosphate; calcium carbonate and calcium carbonate such as calcium carbonate; calcium phosphate, tri-magnesium phosphate, tricalcium phosphate, insoluble calcium metaphosphate, calcium pyrophosphate, and hydroxide Aluminum, aluminum oxide, magnesium carbonate, zirconium silicate, titanium dioxide, a synthetic resin-based abrasive, zeolite, or the like may be used in combination of one or more selected from the group consisting of these.

In particular, it is preferred that the oral composition contains a porous body. Grinding agent.

Thereby, the crude drug component (especially the extract of Astragalus membranaceus, the extract of cassia, and the extract of sputum) can be carried in the pores of the abrasive (porous body), thereby reducing the bitterness of the crude drug.

Among the above various abrasives, it is particularly preferred to use zeolite.

By using the zeolite, it is possible to more preferably carry the crude drug component (especially the extract of Astragalus membranaceus, the extract of cassia, and the extract of sputum) in the pores of the abrasive (porous body), thereby reducing the bitterness of the crude drug.

Examples of the wetting agent include polyhydric alcohols such as glycerin, sorbitol, polyethylene glycol, propylene glycol, ethylene glycol, 1,3-butylene glycol, polypropylene glycol, xylitol, maltitol, and lactitol. One type or two or more types selected from the group consisting of these may be used in combination.

The solvent is, for example, preferably an organic solvent such as an alcohol or water, and examples thereof include ethanol, propanol, and isopropanol, and particularly preferably ethanol.

Examples of the binder include cellulose derivatives such as carrageenan, carboxymethylcellulose, and sodium carboxymethylcellulose; alkali metal alginate such as sodium alginate; and triterpene gum, gum tragacanth, gum arabic, and the like. A gum or a synthetic binder such as polyvinyl alcohol or sodium polyacrylate may be used in combination of one or more selected from the group consisting of these.

Examples of the flavoring agent include known flavoring materials such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, cheese flavor, milk flavor, fruit blend flavor, and tropical fruit flavor. One or more selected from the group consisting of these are used.

Examples of the excipient include sucrose, lactose, starch, glucose, crystalline cellulose, mannitol, sorbitol, xylitol, erythritol, isatin (Palatinit), and para Gold sugar, maltitol, trehalose, lactitol, lactulose, reduced starch sugar, reduced isomaltoligosaccharide, glycoside, gum base, gum arabic, gelatin, cetyl methyl cellulose, light weight Anhydrous citric acid, magnesium aluminate, calcium metasilicate aluminate, sodium hydrogencarbonate, calcium phosphate or the like may be used in combination of one or more selected from the group consisting of these.

Examples of the sweetener include isomalt, aspartame, sodium saccharin, potassium sulfonate, stevioside, neohesperidin dihydrochalcone, glycyrrhizin, perillartine, and soma. One type or two or more types selected from the group consisting of thaumatin, aspartame, methyl phenylalanine, and p-tolyl cinnamaldehyde may be used in combination.

Examples of the pH adjuster include chemically possible salts or hydroxides such as citric acid, phosphoric acid, pantothenic acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, glycerophosphoric acid, acetic acid, nitric acid or disodium hydrogen phosphate. Sodium and so on. Combination of the manner in which the pH of the composition can be in an appropriate range One or more selected from the group consisting of these are used.

Examples of the preservative include p-hydroxybenzoic acid esters, benzoic acid and salts thereof, salicylic acid and salts thereof, sorbic acid and salts thereof, phenoxyethanol, alkyldiaminoethylglycine hydrochloride, and the like. One or two or more selected from the group consisting of these may be used in combination.

Examples of the emulsifier include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, and polyglycerin fatty acid ester. Polyoxyethylene hydrogenated castor oil, sodium stearyl sulphate, soybean phospholipid, alkyltrimethylammonium chloride or the like may be used in combination of one or more selected from the group consisting of these.

Examples of the co-solvent include esters, polyethylene glycol derivatives, polyoxyethylene hydrogenated castor oil, fatty acid esters of sorbitan anhydride, and sulfated fatty alcohols, and the like may be used in combination with one or the like. Two or more.

Examples of the foaming agent include sodium lauryl sulfate, sodium lauryl sarcosinate, sodium alkyl sulfosuccinate, sodium coconut oil fatty acid monoglycerol sulfonate, sodium α-olefin sulfonate, and N-fluorenyl group. N-decylamino acid salt such as glutamate, 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazoline betaine, maltitol fatty acid ester, sucrose fatty acid ester, polyglycerin fatty acid An ester, a fatty acid diethanolamine, a polyoxyethylene sorbitan monostearate, a polyoxyethylene hydrogenated castor oil, a polyoxyethylene fatty acid ester, or the like, which may be used in combination with one of these or Two or more.

Examples of the lubricant include magnesium stearate, sucrose fatty acid ester, talc, and hardened oil, and one type or two or more types selected from the group consisting of these may be used in combination.

Examples of the oil include coconut oil, olive oil, sesame oil, peanut oil, parsley oil, caraway oil, safflower oil, and the like, and one type or two or more types selected from the group consisting of these may be used in combination.

Examples of the surfactant include sodium lauryl sulfate, sodium α-olefin sulfonate, sodium dodecylbenzenesulfonate, sodium lauryl sulfoacetate, sodium N-lauric acid, and N-anthracene. Alkyl glutamate, sucrose fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene block copolymer, alkyl glycoside, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester Further, alkyl dimethyl amine oxide, lauryl ethanol decylamine, coconut oil strontium citrate, sodium N-lauric acid methyl taurine or the like may be used in combination of one or more selected from the group consisting of these.

Examples of the coloring agent include a coloring matter such as blue No. 1 and a pigment such as titanium dioxide or various dyes, and one type or two or more types selected from the group consisting of these may be used in combination.

Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, isoascorbic acid, propyl gallate, and octyl gallate. D-α-tocopherol, vitamin C, vitamin E, disodium edetate, calcium gluconate, and the like.

Examples of the chelating agent include ethylenediaminetetraacetate and the like.

Examples of the flavoring agent include a tea extract, a tea dry liquid, and sodium glutamate, and one type or two or more types selected from the group consisting of these may be used in combination.

Examples of the humectant include amino acid or a salt thereof, pyrrolidone carboxylic acid, mucin, hyaluronic acid or a salt thereof, mucopolysaccharide such as chondroitin sulfate, sodium lactate, urea, panthenol, and aloe extract. a natural extract component such as a rosemary extract, a thyme extract, a tea extract (tea dry extract), a so-called extracellular matrix such as a gelatin or an elastin, or the like, and may be used in combination with one or the like. Two or more.

Examples of the antibacterial agent include phenolic antibacterial agents such as isopropylmethylphenol, triclosan, Japanese tar pitch, and thymol; cetylpyridinium chloride and benzalkonium chloride; Benzethonium chloride, dequalinium chlorid, chlorhexidine hydrochloride, chlorhexidine gluconate, bisabolol Chlorhexidine, lactoferrin A protein (lactoferrin), a paraben, a butyl paraben or the like may be used in combination of one or more selected from the group consisting of these.

Examples of the anti-inflammatory agent include chlorinated lysozyme and ε-amino group. The acid, hydroxy allantoin aluminum, glycyrrhizic acid, glycyrrhizic acid salt, guaiac chamomile sulfonic acid, dl-α-tocopherol acetate, and the like may be used in combination of one or more selected from the group consisting of these.

In addition, examples of the fluoride include sodium fluoride, potassium fluoride, sodium monofluorophosphate, and tin difluoride, and one type or two or more types selected from the group consisting of these may be used in combination.

Examples of the vitamin agent include vitamin A such as retinoic acid and β-carotene; vitamin B such as pantothenic acid or a salt thereof, nicotinic acid or biotin; and vitamin C such as ascorbic acid or its salts and derivatives. A vitamin E such as α-tocopherol or folic acid may be used in combination of one or more selected from the group consisting of these.

Examples of the crude drug other than the above may be exemplified by: golden chrysanthemum, valerian, jujube, hop, lavender, pandan, papaya, honeysuckle, sasa albo-marginata, gumm, clove, and ginseng. Denshichi carrot), a string of red, sapindus, platycodon, rehmannia, peony, hawthorn, angelica, tea, Quercus stenophylla, barley (Hordeum sativum), white birch, ginseng, catechu, turmeric, rosemary, etc. One or two or more selected from the group consisting of these may be used in combination.

When the composition for oral cavity contains the crude drug as described above, the composition for oral cavity may, for example, pulverize the plant in a dry state and directly contain as described above. The crude drug may be contained as an extract component extracted by an extraction solvent such as water or an organic solvent or an extraction medium such as a supercritical fluid, or a component (extract) obtained by removing the extraction medium from the extract component.

The form of the composition for the oral cavity is not particularly limited, and examples thereof include a liquid (emulsified form, solubilized form), a liquid form, a gel form, a paste form, a tablet, a foamed ingot, a powder form, and a granulated form.

Examples of the use of the composition for the oral cavity include a dentifrice, a dentifrice powder, a liquid dentifrice, a liquid dentifrice, and the like; a buccal agent; a lozenge (including a foamed ingot); Ointment; ointment; patch; mouth moisturizer; mouthwash; chewing gum.

"Method for manufacturing oral composition"

The oral composition of the present invention can be obtained by mixing the above respective components.

In particular, when the oral composition contains a porous body, it is preferred to mix the above-mentioned scutellaria, cassia, and sputum with the porous body before mixing with other components.

Thereby, the crude drug can be more conveniently carried in the pores of the porous body.

Although the preferred embodiments of the present invention have been described above, the present invention is not limited by the foregoing.

[Examples]

Hereinafter, the present invention will be described in detail based on examples and comparative examples, but the present invention is not limited thereto.

Manufacture of liquid composition of "1"

The liquid composition (oral composition) of each of the examples and the comparative examples was produced in the following manner.

(Example 1)

A freeze-dried powder of Astragalus membranaceus extract-J (manufactured by Maruzen Pharmaceutical Co., Ltd.), a cinnamon extract W-LA (manufactured by Maruzen Pharmaceutical Co., Ltd.) as a cinnamon extract, and a sputum extract as a sputum extract (Maruzen) The lyophilized powder of the pharmaceutical company was dissolved in water in a specific amount (refer to Table 1) to obtain a liquid composition.

(Examples 2 to 10)

A liquid composition was produced in the same manner as in Example 1 except that the content ratio of each component which is a raw material was changed to that shown in Table 1.

(Comparative Example 1)

A liquid composition was produced in the same manner as in Example 1 except that xanthine, cinnamon and mash were not used as raw materials.

(Comparative Example 2)

A liquid composition was produced in the same manner as in the above Example 1 except that cinnamon and enamel were not used as the raw materials.

(Comparative Example 3)

A liquid composition was produced in the same manner as in Example 1 except that xanthine and yttrium were not used as the raw materials.

(Comparative Example 4)

A liquid composition was produced in the same manner as in Example 1 except that xanthine and cinnamon were not used as the raw materials.

(Comparative Example 5)

A liquid composition was produced in the same manner as in Example 1 except that xanthine was not used as a raw material.

(Comparative Example 6)

A liquid composition was produced in the same manner as in Comparative Example 3 except that the amount of use of cinnamon and water was changed.

The composition and the like of the liquid compositions of the respective Examples and Comparative Examples are summarized in Table 1. Further, in Table 1, the content of xanthine in the liquid composition is represented by X _A [% by mass], and the content of cinnamon in the liquid composition is represented by X _B [% by mass], in the liquid composition The content rate thereafter is expressed by X _C [% by mass].

"2" evaluation

The following evaluations were carried out using the liquid compositions of the respective Examples and Comparative Examples.

Evaluation of the deodorizing effect of "2-1"

Porphyromonas gingivalis suspended in phosphate buffered saline (also known as PBS (Phosphate-Buffered Saline)) in a vial JCM12257) (O.D. 0.3): 4.25 mL, liquid composition as test sample: 0.5 mL and 100 mM aqueous solution of L-methionine: 0.25 mL and mixed. It was subjected to anaerobic culture at 37 ° C for 3 hours in the state of a dense plug.

Further, anaerobic culture was carried out in the same manner as the above method except that distilled water was used as the test sample. Take it as a control.

After anaerobic incubation for 3 hours, the amount of methyl mercaptan produced by the bacteria was determined by gas chromatography.

When the amount of methyl mercaptan in the control is 100, the value obtained by subtracting the amount of residual methyl mercaptan in the liquid composition obtained in each of the examples and the comparative examples from 100 is the deodorization rate (%). . The deodorization rate was evaluated based on the following criteria.

A: The deodorization rate is 55% or more.

B: The deodorization rate is 40% or more and less than 55%.

C: The deodorization rate is 30% or more and less than 40%.

D: The deodorization rate is 20% or more and less than 30%.

E: The deodorization rate is less than 20%.

"2-2" tone

The absorbance of light having a wavelength of 286 nm was measured for the liquid compositions of the above Examples and Comparative Examples, and evaluated based on the following criteria. Can recognize In the case where the absorbance is small, the appearance of the liquid composition is more excellent.

A: The absorbance is less than 25.0.

B: The absorbance is 25.0 or more.

These results are shown in Table 2. Further, in Table 2, the concentration (content ratio) of each component in the above test is also described.

As is clear from Table 2, excellent results were obtained in the present invention, and satisfactory results were not obtained in comparison with the comparative examples. More specifically, by Table 2 In the first embodiment and the comparative examples 2 to 4, it is understood that significant effects can be obtained by using the same in combination with the use of jaundice alone, the use of cassia alone, and the use of hydrazine alone. Further, it can be understood from the first embodiment and the comparative example 5 that the concentration of the two components of the scutellaria, the cassia and the scorpion can be used in combination with the three components of the scutellaria, cinnamon and medlar. Get significant results.

Moreover, the liquid composition of the above-mentioned Example 2 was used as follows, and the toothpaste which is a composition for oral cavity was manufactured. Thereafter, the feeling of use was evaluated.

<Recipe A>

First, the liquid composition of the above Example 1 was added to a specific amount of zeolite as a porous body.

Thereafter, a toothpaste as an oral composition was produced according to the following formula (unit: mass%) according to the following formula.

Huang Wei: 0.001

Cinnamon: 0.0015

茯苓: 0.005

Calcium carbonate: 30.0

Anhydrous citric acid: 5.0

Zeolite: 5.0

Sorbitol solution: 15.0

Concentrated glycerin: 10.0

Sodium Carboxymethyl Cellulose: 1.0

Sodium lauryl sulfate: 0.5

Saccharin sodium: 0.05

Spice: 1.0

Water: balance

<Formulation B>

First, the liquid composition of the above-mentioned Example 1 was mixed with each component of the following mass%. Thereafter, a toothpaste as an oral composition was produced according to the following formula (unit: mass%) according to the following formula.

Huang Wei: 0.001

Cinnamon: 0.0015

茯苓: 0.005

Calcium carbonate: 30.0

Anhydrous citric acid: 5.0

Sorbitol solution: 15.0

Concentrated glycerin: 10.0

Sodium Carboxymethyl Cellulose: 1.0

Sodium lauryl sulfate: 0.5

Saccharin sodium: 0.05

Spice: 1.0

Water: balance

That is, the toothpaste of the formula B is different from the toothpaste of the formula A in that it does not contain the zeolite as a porous body, and accordingly, the water content rate increases.

15 adults were placed on a commercially available toothbrush in an appropriate amount (about 1 g) of the two types of toothpaste (oral composition) obtained in the above manner, and the feeling of use at the time of use was evaluated.

As a result, all 15 people replied that the toothpaste of the formula A (oral composition) and the toothpaste of the formula B (oral composition) were less unpleasant in bitterness and the like.

Further, using the liquid composition (water-containing composition) of the above-mentioned Examples and Comparative Examples, a mouthwash (mouthwash) which is an oral composition was produced according to the following formulation (unit: mass%) according to the following formula. , denture cleaner and denture stabilizer.

<漱口液>

Huang Wei: 0.001

Cinnamon: 0.0015

茯苓: 0.005

Modified Alcohol No. 56: 5.0

Polyoxyethylene hydrogenated castor oil: 0.5

Concentrated glycerin: 5.0

Xylitol: 5.0

Cetylpyridinium chloride: 0.05

Dipotassium glycyrrhizinate: 0.05

Ethyl p-hydroxybenzoate: 0.05

Propyl p-hydroxybenzoate: 0.05

Citric acid: 0.03

Sodium citrate: 0.12

Spice: 1.0

Water: balance

<Dental Cleaner>

Huang Wei: 0.001

Cinnamon: 0.0015

茯苓: 0.005

Anhydrous citric acid: 3.0

Aqueous citric acid: 10.0

Polyethylene glycol 400:5.0

Concentrated glycerin: 35.0

60% by mass sorbitol solution: 30.0

Sodium lauryl sulfate: 2.0

Sodium Carboxymethyl Cellulose: 1.5

Spice: 1.0

Sodium carbonate: moderate amount

Water: balance

<Denture Stabilizer>

Huang Wei: 0.001

Cinnamon: 0.0015

茯苓: 0.005

Zeolite: 5.0

Concentrated glycerin: 30.0

Sodium Carboxymethyl Cellulose: 3.0

Polyoxyethylene hydrogenated castor oil: 1.0

Cetylpyridinium chloride: 0.05

Spice: 1.0

Sodium carbonate: moderate amount

Water: balance

The same evaluation as described above was carried out, and the same results as described above were obtained.

[Industrial availability]

The oral composition of the present invention is characterized by containing xanthine, cinnamon and medlar. Therefore, the oral composition of the present invention can be used in a low dose amount as compared with the use of a separate crude drug, and has an effect of preventing bad breath. Therefore, the oral composition of the present invention has industrial applicability.

Claims (5)

An oral composition comprising scutellaria, cinnamon and medlar. The oral composition according to claim 1, wherein the content of the scutellaria in the oral composition is X _A [% by mass], and the content of the cassia in the oral composition is set to When X _B [% by mass], the relationship of 0.00005 ≦ X _B / X _A ≦ 20000 is satisfied. The oral composition according to claim 1 or 2, wherein the content of the scutellaria in the oral composition is X _A [% by mass], and the content of the sputum in the oral composition is When X _C [% by mass] is set, the relationship of 0.000025 ≦ X _C /X _A ≦40000 is satisfied. The oral composition according to claim 1 or 2, wherein the content of the cassia in the oral composition is X _B [% by mass], and the content of the sputum in the oral composition is When X _C [% by mass] is set, the relationship of 0.000025 ≦ X _C /X _B ≦40000 is satisfied. The oral composition according to claim 1 or 2, comprising at least one of the aforementioned scutellaria, the cinnamon, and the sputum as an extract.