TWI750142B - Dentifrices - Google Patents

Abstract

An oral composition is provided in the present invention. The oral composition contains scutellaria root, cinnamon bark and poria sclerotium. In the oral composition, when an amount of the scutellaria root is defined as X_A [mass%] and an amount of the cinnamon bark is defined as X_B [mass%], it is preferred that the following relation is satisfied: 0.00005

X_B/X_A

20000. In the oral composition, when the amount of the scutellaria root is defined as X_A [mass%] and an amount of the poria sclerotium is defined as X_C [mass%], it is preferred that the following relation is satisfied: 0.000025

X_C/X_A

Description

dentifrice

The present invention relates to an oral composition.

As the oral composition, there are various oral compositions ranging from those that physically remove dirt adhering to the teeth to those that are formulated with medicinal components in order to produce various medicinal effects.

In particular, oral compositions containing botanical ingredients (especially crude drug ingredients with a long history) that are ingredients derived from natural substances have physiological activity, and are therefore safer than ingredients derived from non-natural substances The aspect is more excellent, so it is especially needed in this technical field. (Refer to Patent Documents 1 to 3).

In recent years, further improvement in the effect of preventing bad breath has been demanded for oral compositions.

[Prior Art Literature] [Patent Literature]

Patent Document 1: Japanese Patent Laid-Open No. 2015-54847.

Patent Document 2: Japanese Patent Laid-Open No. 6-25000.

Patent Document 3: Japanese Patent Laid-Open No. 2011-256136.

The object of the present invention is to provide an oral composition having the effect of preventing bad breath, which is prepared with a plurality of crude drugs, and can obtain the effect at a lower dose than using the crude drug alone.

Such objects can be achieved by the present invention of the following (1) to (5).

(1) An oral composition containing Scutellaria baicalensis, cinnamon bark, and Poria cocos.

(2) The oral composition according to the above (1), wherein the content of the Scutellaria baicalensis in the oral composition is X _A [mass %], and the content of the cinnamon in the oral composition is When the content rate is X _B [mass %], the relationship of 0.00005≦X _B /X _A ≦20000 is satisfied.

(3) The oral composition according to the above (1) or (2), wherein the content of the Scutellaria baicalensis in the oral composition is X _A [mass %], and the oral composition is When the content rate of the above-mentioned Poria is set as X _C [mass %], the relationship of 0.000025≦X _C /X _A ≦40000 is satisfied.

(4) The oral composition according to any one of the above (1) to (3), wherein the content of the cinnamon bark in the oral composition is X _B [mass %], and the oral composition is _{When X C} [mass %] is used as the content rate of the said Poria in the composition, the relationship of 0.000025≦X _C /X _B ≦40000 is satisfied.

(5) The oral composition according to any one of the above (1) to (4), which contains at least one of the Scutellaria baicalensis, the cinnamon bark, and the Poria cocos as an extract.

According to the present invention, an oral composition having a halitosis preventive effect can be provided, which is prepared with a plurality of crude drugs and can obtain the effect at a lower dose than using a single crude drug.

Hereinafter, preferred embodiments of the present invention will be described in detail.

"Oral Composition"

As the oral composition, there are various oral compositions ranging from those that physically remove dirt adhering to the teeth to those that are formulated with medicinal components in order to produce various medicinal effects.

In particular, containing botanical ingredients as ingredients derived from natural substances (especially The oral composition, which has a long history of crude drug ingredients), has physiological activity and is more excellent in safety than ingredients derived from non-natural substances, and is therefore particularly demanded in this technical field.

In recent years, further improvement in the effect of preventing bad breath has been demanded for oral compositions.

Therefore, the inventors of the present invention conducted intensive research, and found that by combining Scutellaria baicalensis, cinnamon bark, and Poria cocos in various crude drugs in oral compositions, these can be synergistically exerted to obtain excellent efficacy.

That is, the oral composition of the present invention contains Scutellaria baicalensis, cinnamon bark, and Poria cocos. By containing Scutellaria baicalensis, cinnamon bark and Poria cocos, excellent halitosis prevention effect can be obtained. In particular, even in the case of using the crude drug alone, even in the case of a low content rate where no effect can be obtained at all, a sufficiently excellent effect of preventing bad breath can be obtained.

Furthermore, the aforementioned documents have descriptions of various crude drugs, but there is no specific disclosure about the oral composition of Scutellaria baicalensis, Cinnamon bark, and Poria cocos.

In the present invention, the oral composition can directly contain Scutellaria baicalensis, Cinnamon bark and Poria cocos by pulverizing plants in a dry state, or can be used as an extraction component extracted using an extraction solvent such as water or an organic solvent or an extraction medium such as a supercritical fluid, Or the components obtained by removing the extraction medium from the extraction components (hereinafter, these are collectively referred to as extracts) are contained.

In particular, it is preferable that the oral composition contains at least one of Scutellaria baicalensis, cinnamon bark, and Poria cocos as extracts, and it is more preferable to contain all of Scutellaria baicalensis, cinnamon bark, and Poria cocos as extracts.

Thereby, quality unevenness between manufacturing batches can be suppressed, and stable quality can be obtained.

Moreover, in a composition for oral cavity, a preferable component among the components derived from a natural substance can be contained in a high content rate, and the content rate of an unsatisfactory component can be suppressed low. As a result, for example, the color tone, flavor, etc. of the oral composition can be prevented from being lowered, and the desired effect can be more reliably exhibited. In addition, more excellent stability of the active ingredient in the oral composition can be obtained. Therefore, the storage stability of the entire oral composition can be improved, the useful life of the oral composition can be further extended, and the storage conditions can be eased.

As the extraction solvent for obtaining the extracts of Scutellaria baicalensis, cinnamon bark, and Poria cocos, for example, various inorganic solvents and various organic solvents can be used. More specifically, water; monohydric alcohols such as methanol, ethanol, propanol, isopropanol, butanol, isobutanol, octanol, and phenol; propylene glycol, 1,3-butanediol, 1,2- Butanediol, 1,4-butanediol, 1,5-pentanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5- Polyols such as pentanetriol, glycerol, polyethylene glycol (molecular weight 1 million to 100,000); ketones such as acetone and methyl ethyl ketone; esters such as ethyl acetate and methyl acetate; diethyl ether and dimethyl ether , ethyl methyl ether, Ethers such as dioxane; nitriles such as acetonitrile; halides such as chloroform and carbon tetrachloride; aliphatic hydrocarbons such as hexane, octane, and cyclohexane; aromatic hydrocarbons such as xylene, toluene, and benzene, etc., which can be combined One or two or more selected from these are used. Further, as the extraction solvent, an acid (for example, hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) or a base (for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.) whose normal concentration is appropriately adjusted can also be used.

Among them, as the extraction solvent for obtaining the extract of Scutellaria baicalensis, it is preferable to use an aqueous ethanol solution.

Thereby, the aforementioned effects can be exerted more remarkably.

In particular, the concentration of the aqueous ethanol solution (the ethanol content) of the extraction solvent used to obtain the extract of Scutellaria baicalensis is preferably 30 vol% or more and 95 vol% or less, more preferably 40 vol% or more and 70 vol% or less.

Thereby, the aforementioned effects can be further remarkably exerted.

Moreover, as an extraction solvent for obtaining the cinnamon bark extract, the solvent containing water is preferable.

Thereby, the aforementioned effects can be exerted more remarkably.

In particular, the content rate of water contained in the extraction solvent for obtaining the cinnamon bark extract is preferably 90% by mass or more, more preferably 95% by mass or more.

Thereby, the aforementioned effects can be further remarkably exerted.

Moreover, it is preferable to use an ethanol aqueous solution as an extraction solvent for obtaining the extract of Poria cocos.

Thereby, the aforementioned effects can be exerted more remarkably.

In particular, the concentration of the aqueous ethanol solution (the ethanol content) of the extraction solvent used to obtain the Poria cocos extract is preferably 30 vol% or more and 95 vol% or less, more preferably 45 vol% or more and 85 vol% or less.

Thereby, the aforementioned effects can be further remarkably exerted.

The oral composition may contain Scutellaria baicalensis, cinnamon bark, and Poria in any form, for example, in powder or granular form, as an oily component, or dissolved in other components.

The content of Scutellaria baicalensis in the oral composition (the content of Scutellaria baicalensis in dry state) is not particularly limited, but is preferably 0.00001 mass % or more and 10 mass % or less, more preferably 0.0001 mass % or more and 2.0 mass % or less, and more preferably Preferably it is 0.0005 mass % or more and 0.05 mass % or less.

If the content rate of Scutellaria baicalensis does not reach the said lower limit, there exists a possibility that the effect by this invention may not fully be exhibited depending on the content rate of cassia bark, Poria, etc.

In addition, when the content rate of Scutellaria baicalensis exceeds the above-mentioned upper limit value, there is a problem that coloring occurs more remarkably, and a feeling of use is deteriorated due to an odor such as bitterness. downgrade problems.

The content of cinnamon in the oral composition (content of cassia in dry state) is not particularly limited, but is preferably 0.00001 mass % or more and 10 mass % or less, more preferably 0.0001 mass % or more and 2.0 mass % or less, and more Preferably it is 0.0008 mass % or more and 0.1 mass % or less.

If the content rate of cassia bark is less than the said lower limit, there exists a possibility that the effect by this invention may not fully be exhibited according to the content rate of Scutellaria baicalensis, Poria, etc.

Moreover, when the content rate of a cinnamon bark exceeds the said upper limit, the problem of coloring, and the problem of a feeling of use reduction by peculiar smells, such as bitterness, etc. may arise more remarkably.

The content rate of Poria cocos in the oral composition (content rate of Poria cocos in a dry state) is not particularly limited, but is preferably 0.00001 mass % or more and 10 mass % or less, more preferably 0.00005 mass % or more and 4.0 mass % or less, and more preferably Preferably it is 0.002 mass % or more and 1.0 mass % or less.

If the content rate of Poria cocos does not reach the said lower limit, there exists a possibility that the effect by this invention may not fully be exhibited according to the content rate of Scutellaria baicalensis, cinnamon bark, etc.

Moreover, when the content rate of Poria cocos exceeds the said upper limit value, the problem of coloring, the problem of the fall in use feeling by odor, etc., such as bitterness, may arise more remarkably.

When the content rate of Scutellaria baicalensis in the oral composition is X _A [mass %] and the content rate of cinnamon in the oral composition is X _B [mass %], it is preferable to satisfy 0.00005≦X _B / The relationship of X _A ≦20000 is more preferably satisfied the relationship of 0.015≦X _B /X _A ≦200, and more preferably the relationship of 0.03≦X _B /X _A ≦100 is satisfied.

Thereby, a more excellent effect of preventing bad breath can be obtained, and at the same time, a more excellent storage stability of the oral composition can be obtained.

When the content rate of Scutellaria baicalensis in the oral composition is X _A [mass %] and the content rate of Poria cocos in the oral composition is X _C [mass %], it is preferable to satisfy 0.000025≦X _C / The relationship of X _A ≦40000 is more preferably satisfied the relationship of 0.04≦X _C /X _A ≦2000, and more preferably the relationship of 0.1≦X _C /X _A ≦1000 is satisfied.

Thereby, a more excellent effect of preventing bad breath can be obtained, and at the same time, a more excellent storage stability of the oral composition can be obtained.

When the content rate of cinnamon in the oral composition is X _B [mass %] and the content rate of Poria cocos in the oral composition is X _C [mass %], it is preferable to satisfy 0.000025≦X _C / The relationship of X _B ≦40000 is more preferably satisfied the relationship of 0.02≦X _C /X _B ≦1250, and more preferably the relationship of 0.05≦X _C /X _B ≦700 is satisfied.

Thereby, a more excellent effect of preventing bad breath can be obtained, and at the same time, a more excellent storage stability of the oral composition can be obtained.

The oral composition of the present invention may contain components other than those described above.

Examples of such components (other components) include abrasives, wetting agents, solvents, binders, fragrances, excipients, sweeteners, pH adjusters, preservatives, emulsifiers, solubilizers, foaming agents Agents, lubricants, oils, surfactants, colorants, antioxidants, chelating agents, flavoring agents, moisturizing agents, antibacterial agents, anti-inflammatory agents, fluorides, vitamin agents, crude drugs other than the above, and the like.

Examples of abrasives include silica-based abrasives such as silica gel, precipitated silica, fumed silica, hydrous silicic acid, anhydrous silicic acid, aluminosilicate, and zirconium silicate; dihydrate hydrogen phosphate Calcium, calcium hydrogen phosphate anhydrous and other calcium hydrogen phosphate for dental cleaning; light calcium carbonate, heavy calcium carbonate and other calcium carbonate; calcium phosphate, trimagnesium phosphate, tricalcium phosphate, insoluble calcium metaphosphate, calcium pyrophosphate, hydroxide Aluminum, alumina, magnesium carbonate, zirconium silicate, titanium dioxide, synthetic resin-based abrasives, zeolite, etc., may be used in combination of one or two or more selected from these.

In particular, it is preferable that the oral composition contains a abrasive.

Thereby, the above-mentioned crude drug ingredients (especially the extract of Scutellaria baicalensis, the extract of cinnamon, and the extract of Poria cocos) can be supported in the pores of the abrasive (porous body), thereby reducing the bitterness of the crude drug.

Among the above-mentioned various abrasives, it is particularly preferable to use zeolite.

By using zeolite, the crude drug ingredients (especially the extract of Scutellaria baicalensis, the extract of cinnamon, and the extract of Poria cocos) can be better supported in the pores of the abrasive (porous body), thereby reducing the bitterness of the crude drug.

Examples of the wetting agent include polyhydric alcohols such as glycerin, sorbitol, polyethylene glycol, propylene glycol, ethylene glycol, 1,3-butanediol, polypropylene glycol, xylitol, maltitol, and lactitol. One kind or two or more kinds selected from these can be used in combination.

As a solvent, an organic solvent, such as alcohol, or water is preferable, for example, ethanol, propanol, isopropanol, etc. are mentioned, for example, ethanol is especially preferable.

Examples of the binder include cellulose derivatives such as carrageenan, carboxymethyl cellulose, and sodium carboxymethyl cellulose; alkali metal alginates such as sodium alginate; gum sanxian, gum tragacanth, gum arabic, etc. Adhesives; synthetic binders such as polyvinyl alcohol and sodium polyacrylate, etc., one or more of them can be used in combination.

Examples of the flavor include known flavoring materials such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, cheese flavor, milk flavor, fruit blend flavor, tropical fruit flavor, and other blended flavors, and the like can be combined. One or two or more selected from these are used.

Examples of excipients include: sucrose, lactose, starch, glucose, crystalline cellulose, mannitol, sorbitol, xylitol, erythritol, isomalt (Palatinit), paratha Gold sugar, maltitol, trehalose, lactitol, lactulose, reduced starch sugar, reduced isomalt oligosaccharide, glycoside, gum base, gum arabic, gelatin, cetyl methyl cellulose, light Anhydrous silicic acid, magnesium aluminate, calcium aluminate metasilicate, sodium bicarbonate, calcium phosphate, etc., may be used in combination of one or two or more selected from these.

Examples of sweeteners include isomalt, aspartame, sodium saccharin, acesulfame potassium, stevioside, neohesperidin dihydrochadone, licorice, perillartine, soma Sweet (thaumatin), methyl aspartame, p-tolyl cinnamaldehyde, etc., can be used in combination of one or two or more selected from these.

Examples of pH adjusters include chemically possible salts or hydroxides such as citric acid, phosphoric acid, pantothenic acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, glycerophosphoric acid, acetic acid, nitric acid, and disodium hydrogen phosphate. sodium etc. These can be combined in such a way that the pH of the composition becomes an appropriate range One or two or more selected from these are used.

Examples of preservatives include parabens, benzoic acid and its salts, salicylic acid and its salts, sorbic acid and its salts, phenoxyethanol, alkyldiaminoethylglycine hydrochloride, and the like , can be used in combination of one or two or more selected from these.

Examples of emulsifiers include polyoxyethylene alkyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene sorbitan fatty acid esters, sorbitan fatty acid esters, glycerol fatty acid esters, polyglycerol fatty acid esters, Polyoxyethylene hydrogenated castor oil, sodium stearyl lactate, soybean lecithin, alkyltrimethylammonium chloride, etc., may be used in combination of one or two or more selected from these.

Examples of cosolvents include esters, polyethylene glycol derivatives, polyoxyethylene hydrogenated castor oil, fatty acid esters of sorbitan, sulfated fatty alcohols, and the like, and one or more selected from these may be used in combination. two or more.

As the foaming agent, for example, sodium lauryl sulfate, sodium lauryl sarcosinate, sodium alkyl sulfosuccinate, sodium coconut fatty acid monoglycerol sulfonate, sodium α-olefin sulfonate, N-sulfonic acid sodium N-Amino acid salts such as glutamate, 2-Alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, maltitol fatty acid esters, sucrose fatty acid esters, polyglycerol fatty acids Esters, fatty acid diethanolamide, polyoxyethylene sorbitan monostearate, polyoxyethylene hydrogenated castor oil, polyoxyethylene fatty acid ester, etc., can be used in combination with one selected from these or two or more.

Examples of the lubricant include magnesium stearate, sucrose fatty acid ester, talc, hardened oil, and the like, and one or two or more selected from these can be used in combination.

Examples of oils include coconut oil, olive oil, sesame oil, peanut oil, parsley oil, parsley seed oil, safflower oil, and the like, and one or two or more selected from these can be used in combination.

As the surfactant, for example, sodium lauryl sulfate, sodium α-olefin sulfonate, sodium dodecylbenzenesulfonate, sodium lauryl sulfoacetate, sodium N-lauryl sarcosinate, N- Glutamate, sucrose fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene block copolymer, alkyl glycosides, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester , alkyl dimethyl amine oxide, lauryl glycolamide, coconut oil sodium sarcosinate, N-lauryl methyl taurine sodium solution, etc., can be used in combination with one or two or more selected from these.

Examples of the colorant include dyes such as blue No. 1, pigments such as titanium dioxide, various dyes, and the like, and one or two or more selected from these can be used in combination.

Examples of antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, erythorbic acid, propyl gallate, octyl gallate, d-α-tocopherol, vitamin C, vitamin E, disodium EDTA, calcium gluconate, etc.

As a chelating agent, ethylenediaminetetraacetate etc. are mentioned, for example.

As a flavoring agent, a tea extract, tea dry distillation liquid, sodium glutamate, etc. are mentioned, for example, One or two or more types selected from these can be used in combination.

Examples of the moisturizing agent include amino acid or its salt, pyrrolidone carboxylic acid, mucin, hyaluronic acid or its salt, mucopolysaccharides such as chondroitin sulfate, sodium lactate, urea, panthenol, and aloe vera extract. Natural extracts such as extracts, rosemary extracts, thyme extracts, tea extracts (tea dry distillation extracts), so-called extracellular matrices such as collagen and elastin, etc., one or more selected from these can be used in combination. two or more.

Examples of antibacterial agents include phenol-based antibacterial agents such as isopropylmethylphenol, triclosan, cypress oil, and thymol; cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, dequalinium chlorid, chlorhexidine hydrochloride, sodium chlorhexidine gluconate, bisabolol Chlorhexidine, lactoferrin Protein (lactoferrin), paraben, butylparaben, etc., can be used in combination of one or two or more selected from these.

Examples of anti-inflammatory agents include lysozyme chloride, ε-aminohexan Acid, aluminum hydroxyallantoin, glycyrrhizic acid, salts of glycyrrhizinate, guaiacol sulfonic acid, dl-α-tocopherol acetate, etc., may be used in combination of one or two or more selected from these.

Moreover, as a fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, tin difluoride etc. are mentioned, for example, One or two or more types selected from these can be used in combination.

Examples of vitamin agents include vitamins A such as retinoic acid and β-carotene; vitamin Bs such as pantothenic acid or its salts, nicotinic acid, and biotin; and vitamin Cs such as ascorbic acid or its salts and derivatives. ; Vitamin E such as α-tocopherol, folic acid, etc., can be used in combination of one or two or more selected from these.

Examples of crude drugs other than the above include: goldenrod, valerian, jujube, hops, lavender, elixir, papaya, honeysuckle, sasa albo-marginata, gum (Gummi), clove, ginseng denshichi carrot), a bunch of red, Sapindus japonica, Campanulaceae, Rehmannia glutinosa, peony, hawthorn, angelica, tea, Quercus stenophylla, barley (Hordeum sativum), birch, ginseng, catechu, turmeric, rosemary, etc. , can be used in combination of one or two or more selected from these.

In the case where the oral composition contains the aforementioned crude drug, the oral composition may, for example, pulverize a dried plant to directly contain the aforementioned crude drug. The crude drug may be contained as an extraction component extracted using an extraction solvent such as water or an organic solvent or an extraction medium such as a supercritical fluid, or a component (extract) obtained by removing the extraction medium from the extraction component.

The form of the oral composition is not particularly limited, and examples thereof include liquid (emulsified form, solubilized form), liquid form, gel form, paste form, tablet, foamable tablet, powder, granule, and the like.

Examples of uses of the oral composition include dentifrices such as toothpaste, dentifrice, liquid dentifrice, and liquid dentifrice; buccal preparations; lozenges (including foaming lozenges, etc.); creams Agent; ointment; patch; mouth moisturizing agent; mouthwash; chewing gum, etc.

"Manufacturing method of oral composition"

The oral composition of the present invention can be obtained by mixing the aforementioned components.

In particular, when the oral composition contains a porous body, it is preferable to mix the above-mentioned Scutellaria baicalensis, cinnamon bark, and Poria cocos with the porous body in advance, and then mix them with other components.

Thereby, the crude drug can be supported in the pores of the porous body more preferably.

The preferred embodiments of the present invention have been described above, but the present invention is not limited to the foregoing.

[Example]

Hereinafter, the present invention will be described in detail based on Examples and Comparative Examples, but the present invention is not limited thereto.

《1》Manufacture of liquid composition

The liquid composition (oral composition) of each Example and each comparative example was produced in the following manner.

(Example 1)

The freeze-dried powder of Scutellaria baicalensis extract-J (manufactured by Maruzen Pharmaceutical Co., Ltd.) as the Scutellaria baicalensis extract, the cassia extract W-LA (manufactured by Maruzen Pharmaceutical Co., Ltd.) as the cassia bark extract, and the Poria cocos extract (manufactured by Maruzen Pharmaceutical Co., Ltd.) The freeze-dried powder (manufactured by a pharmaceutical company) was dissolved in water in a specific amount (refer to Table 1) to obtain a liquid composition.

(Examples 2 to 10)

A liquid composition was produced in the same manner as in Example 1 above, except that the content of each component used as a raw material was changed as shown in Table 1.

(Comparative Example 1)

A liquid composition was produced in the same manner as in the aforementioned Example 1, except that Scutellaria baicalensis, cinnamon bark, and Poria cocos were not used as raw materials.

(Comparative Example 2)

A liquid composition was produced in the same manner as in the aforementioned Example 1, except that cinnamon bark and Poria cocos were not used as raw materials.

(Comparative Example 3)

A liquid composition was produced in the same manner as in the aforementioned Example 1, except that Scutellaria baicalensis and Poria baicalensis were not used as raw materials.

(Comparative Example 4)

A liquid composition was produced in the same manner as in the aforementioned Example 1, except that Scutellaria baicalensis and cinnamon were not used as raw materials.

(Comparative Example 5)

A liquid composition was produced in the same manner as in the aforementioned Example 1, except that Huang Ling was not used as a raw material.

(Comparative Example 6)

A liquid composition was produced in the same manner as in Comparative Example 3 above, except that the amounts of cinnamon and water to be used were changed.

Table 1 summarizes the composition and the like of the liquid compositions in each of the aforementioned Examples and Comparative Examples. In addition, in Table 1, the content rate of Scutellaria baicalensis in the _{liquid composition is represented by X A} [mass %], the content rate of cinnamon bark in the liquid composition is represented by X _B [mass %], and the liquid composition is represented by X B [mass %]. The content of Poria cocos is represented by X _C [mass %].

"2" evaluation

The following evaluations were performed using the liquid compositions of each of the foregoing Examples and each of Comparative Examples.

Evaluation of "2-1" Deodorant Efficacy

Porphyromonas gingivalis (Porphyromonas gingivalis) suspended in phosphate-buffered saline (ie PBS (Phosphate-Buffered Saline; Phosphate-buffered saline)) was put into a vial JCM12257) (O.D.0.3): 4.25 mL, liquid composition as test sample: 0.5 mL, and 100 mM L-methionine aqueous solution: 0.25 mL and mixed. It was cultured anaerobically at 37°C for 3 hours in a tightly plugged state.

In addition, anaerobic culture was performed in the same manner as the above-mentioned method except that distilled water was used as the test sample. Use this as a control.

After these were subjected to anaerobic culture for 3 hours, the amount of methyl mercaptan of the producing bacteria was measured by gas chromatography.

When the methyl mercaptan amount of the control is set as 100, the value obtained by subtracting the residual methyl mercaptan amount of the liquid composition obtained in each example and each comparative example from 100 is the deodorization rate (%) . The deodorization rate was evaluated according to the following criteria.

A: The deodorizing rate is 55% or more.

B: The deodorization rate is 40% or more and less than 55%.

C: The deodorization rate is 30% or more and less than 40%.

D: The deodorizing rate is 20% or more and less than 30%.

E: The deodorization rate is less than 20%.

"2-2" Hue

The absorbance of light with a wavelength of 286 nm was measured for the liquid compositions of the above-mentioned examples and the above-mentioned comparative examples, and evaluated according to the following criteria. can be recognized It is because the appearance of the liquid composition is more excellent when the absorbance is small.

A: The absorbance is less than 25.0.

B: The absorbance is 25.0 or more.

These results are shown in Table 2. In addition, in Table 2, the density|concentration (content rate) of each component at the time of the said test is combined and described.

As is clear from Table 2, excellent results were obtained in the present invention, whereas satisfactory results were not obtained in the comparative examples. More specifically, from Table 2 It can be seen from Example 1 and Comparative Examples 2 to 4 that at the concentrations where Scutellaria baicalensis alone, Cinnamon bark alone, and Poria cocos alone have no effect at all, significant effects can be obtained by using them together. In addition, it is clear from Example 1 and Comparative Example 5 that in the case of using only two components of Scutellaria baicalensis, Cinnamon bark, and Poria cocos, at a concentration that is completely ineffective, the combination of three components of Scutellaria baicalensis, Cinnamon bark, and Poria cocos can also be used together. Get significant results.

Moreover, using the liquid composition of the said Example 2 as follows, the toothpaste which is a composition for oral cavity was manufactured. Then, the usability was evaluated.

<Recipe A>

First, the liquid composition of Example 1 was added to a specific amount of zeolite as a porous body.

Then, according to the following formulation (unit: mass %), the toothpaste which is a composition for oral cavity was manufactured according to an ordinary method.

Skullcap: 0.001

Cinnamon: 0.0015

Poria: 0.005

Calcium carbonate: 30.0

Anhydrous silicic acid: 5.0

Zeolite: 5.0

Sorbitol liquid: 15.0

Concentrated glycerin: 10.0

Sodium carboxymethylcellulose: 1.0

Sodium Lauryl Sulfate: 0.5

Sodium Saccharin: 0.05

Spices: 1.0

water: balance

<Recipe B>

First, the liquid composition of the above-mentioned Example 1 was mixed with each component of the following mass %. Then, according to the following formulation (unit: mass %), the toothpaste which is a composition for oral cavity was manufactured according to an ordinary method.

Skullcap: 0.001

Cinnamon: 0.0015

Poria: 0.005

Calcium carbonate: 30.0

Anhydrous silicic acid: 5.0

Sorbitol liquid: 15.0

Concentrated glycerin: 10.0

Sodium carboxymethylcellulose: 1.0

Sodium Lauryl Sulfate: 0.5

Sodium Saccharin: 0.05

Spices: 1.0

water: balance

That is, the toothpaste of formula B differs from the toothpaste of formula A in that it does not contain zeolite as a porous body, and accordingly the content rate of water increases.

An appropriate amount (about 1 g) of the two kinds of toothpastes (oral composition) obtained in the above-mentioned manner was put on a commercially available toothbrush by 15 adults, and the feeling of use during use was evaluated.

As a result, all 15 people answered that the toothpaste (oral composition) of formulation A had less unpleasantness such as bitterness than when using the toothpaste (oral composition) of formulation B.

Moreover, using the liquid compositions (compositions containing water) of the aforementioned Examples and Comparative Examples, according to the following formulation (unit: mass %), a mouthwash (mouthwash) as an oral composition was produced according to a conventional method. , denture cleaners and denture stabilizers.

<Mouthwash>

Skullcap: 0.001

Cinnamon: 0.0015

Poria: 0.005

Modified alcohol No. 56: 5.0

Polyoxyethylene hydrogenated castor oil: 0.5

Concentrated glycerin: 5.0

Xylitol: 5.0

Cetylpyridinium chloride: 0.05

Dipotassium glycyrrhizinate: 0.05

Ethylparaben: 0.05

Propylparaben: 0.05

Citric acid: 0.03

Sodium citrate: 0.12

Spices: 1.0

water: balance

<Dental cleaner>

Skullcap: 0.001

Cinnamon: 0.0015

Poria: 0.005

Anhydrous silicic acid: 3.0

Hydrous silicic acid: 10.0

Macrogol 400: 5.0

Concentrated glycerin: 35.0

60 mass % sorbitol liquid: 30.0

Sodium Lauryl Sulfate: 2.0

Sodium carboxymethylcellulose: 1.5

Spices: 1.0

Sodium carbonate: appropriate amount

water: balance

<Dental Stabilizer>

Skullcap: 0.001

Cinnamon: 0.0015

Poria: 0.005

Zeolite: 5.0

Concentrated glycerin: 30.0

Sodium carboxymethylcellulose: 3.0

Polyoxyethylene hydrogenated castor oil: 1.0

Cetylpyridinium chloride: 0.05

Spices: 1.0

Sodium carbonate: appropriate amount

water: balance

The same evaluations as described above were carried out on these, and the same results as described above were obtained.

[Industrial Availability]

The oral composition of the present invention is characterized by containing Scutellaria baicalensis, cinnamon bark and Poria cocos. Therefore, the oral composition of the present invention can obtain the effect at a lower dosage than using the crude drug alone, and has the effect of preventing bad breath. Therefore, the oral composition of the present invention has industrial applicability.

Claims (5)

A dentifrice comprising Scutellaria baicalensis, cinnamon bark and Poria; the content rate of the aforementioned Scutellaria baicalensis in the aforementioned dentifrice is 0.001 mass % or more to 2.0 mass % or less; the content ratio of the aforementioned cinnamon bark in the aforementioned dentifrice agent is 0.0008 mass % More than 2.0 mass % or less; The content rate of the said Poria in the said dentifrice is 0.002 mass % or more and 4.0 mass % or less. The dentifrice according to claim 1, wherein the content of the scutellaria baicalensis in the dentifrice is X _A [mass %], and the content of the cinnamon in the dentifrice is X _B [ mass %], the relationship of 0.00005≦X _B /X _A ≦20000 is satisfied. The dentifrice according to claim 1 or 2, wherein the content rate of the Scutellaria baicalensis in the dentifrice is X _A [mass %], and the content rate of the Poria cocos in the dentifrice is X _{In the case of C} [mass %], the relationship of 0.000025≦X _C /X _A ≦40000 is satisfied. The dentifrice according to claim 1 or 2, wherein the content of the cinnamon bark in the dentifrice is X _B [mass %], and the content of the Poria cocos in the dentifrice is X _{In the case of C} [mass %], the relationship of 3.3≦X _C /X _B ≦2667 is satisfied. The dentifrice according to claim 1 or 2, wherein the content of the scutellaria baicalensis in the dentifrice is 0.001 mass % or more and 0.05 mass % or less; and the content ratio of the cinnamon bark in the dentifrice is 0.0008 mass % % or more and 0.1 mass % or less; the content rate of the aforementioned Poria in the aforementioned dentifrice is 0.002 mass % or more and 1.0 mass % or less.