TW201720422A - Liquid oral cavity composition contained in foam dispensing container for effectively promoting the adsorption of a cationic bactericide on the surface of the oral cavity - Google Patents
Liquid oral cavity composition contained in foam dispensing container for effectively promoting the adsorption of a cationic bactericide on the surface of the oral cavity Download PDFInfo
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Abstract
Description
本發明係關於一種泡噴出容器裝之液體口腔用組合物。 The present invention relates to a liquid oral composition for a bubble spray container.
先前以來,已知有一種為了於使用時以泡狀自噴出口應用於口腔內而填充於能夠泡狀地噴出內容物之容器、且發揮所需性能之口腔用組合物。例如,於專利文獻1~2中揭示有含有界面活性劑、及特定之黏結劑或陽離子性聚合物之口腔用組合物,其等均為填充於非氣溶膠型之無氣體常壓容器、能夠提高泡之保形性或穩定性且帶來良好之使用感受等之組合物。又,專利文獻3中,藉由將2種以上陰離子界面活性劑與如脂肪酸二烷醇醯胺之特定之非離子界面活性劑併用,而以泡沫狀之口腔用組合物之形式謀求泡保持力等之穩定化。 Conventionally, there has been known an oral composition which is filled in a container capable of ejecting a content in a bubble form in a bubble form from a discharge port, and which exhibits desired performance. For example, Patent Literatures 1 to 2 disclose an oral composition containing a surfactant and a specific binder or a cationic polymer, which are all filled with a non-aerosol type gas-free atmospheric pressure container and capable of being filled. A composition which improves the shape retention or stability of the foam and which gives a good feeling of use and the like. Further, in Patent Document 3, by using two or more kinds of anionic surfactants together with a specific nonionic surfactant such as fatty acid dialkamine, foam retention is achieved in the form of a foamy oral composition. Stabilization.
進而,於專利文獻4中揭示有一種含有陰離子界面活性劑、非離子界面活性劑或兩性界面活性劑、及黏稠劑或黏結劑等之泡狀口腔用組合物,其保持良好之泡持續性等,且提高該組合物於口腔內之分散性。 Further, Patent Document 4 discloses a foamed oral composition containing an anionic surfactant, a nonionic surfactant or an amphoteric surfactant, and a thickener or a binder, which maintains good bubble persistence and the like. And increasing the dispersibility of the composition in the oral cavity.
(專利文獻1)日本專利特開平9-295923號公報 (Patent Document 1) Japanese Patent Laid-Open No. Hei 9-295923
(專利文獻2)日本專利特開2001-172144號公報 (Patent Document 2) Japanese Patent Laid-Open Publication No. 2001-172144
(專利文獻3)日本專利特開平10-139643號公報 (Patent Document 3) Japanese Patent Laid-Open No. Hei 10-139643
(專利文獻4)日本專利特開平8-333226號公報 (Patent Document 4) Japanese Patent Laid-Open No. Hei 8-333226
本發明係關於一種泡噴出容器裝之液體口腔用組合物,其含有 如下成分(A)、(B)及(C):(A)烷基硫酸鈉0.05質量%以上且1質量%以下、(B)陽離子性殺菌劑0.001質量%以上且0.1質量%以下、及(C)水,且成分(B)與成分(A)之質量比((B)/(A))為0.005以上且0.7以下,且非離子界面活性劑之含量為1.2質量%以下。 The present invention relates to a liquid oral composition containing a bubble spray container, which comprises The following components (A), (B), and (C): (A) a sodium alkyl sulfate of 0.05% by mass or more and 1% by mass or less, and (B) a cationic bactericide: 0.001% by mass or more and 0.1% by mass or less, and ( C) Water, and the mass ratio of the component (B) to the component (A) ((B)/(A)) is 0.005 or more and 0.7 or less, and the content of the nonionic surfactant is 1.2 mass% or less.
又,本發明係關於一種陽離子性殺菌劑之口腔內表面吸附促進劑,其以泡狀製劑作為有效成分,該泡狀製劑含有如下成分(A)、(B)及(C):(A)烷基硫酸鈉0.05質量%以上且1質量%以下、(B)陽離子性殺菌劑0.001質量%以上且0.1質量%以下、及(C)水,且成分(B)與成分(A)之質量比((B)/(A))為0.005以上且0.7以下,且非離子界面活性劑之含量為1.2質量%以下。 Further, the present invention relates to an oral surface adsorption promoter for a cationic bactericide which comprises a foam preparation as an active ingredient, and the blister preparation contains the following components (A), (B) and (C): (A) 0.05% by mass or more and 1% by mass or less of the sodium alkyl sulfate, (B) 0.001% by mass or more and 0.1% by mass or less of the cationic bactericide, and (C) water, and the mass ratio of the component (B) to the component (A) ((B)/(A))) is 0.005 or more and 0.7 or less, and the content of the nonionic surfactant is 1.2 mass% or less.
為了於口腔內有效地防止或預防牙齦炎或牙周炎、或口臭,有效的是使陽離子性殺菌劑吸附於口腔黏膜,抑制因口腔內細菌而引起之生物膜形成。 In order to effectively prevent or prevent gingivitis or periodontitis or bad breath in the oral cavity, it is effective to adsorb a cationic bactericide to the oral mucosa and suppress the formation of a biofilm caused by bacteria in the oral cavity.
然而,於上述任一文獻所記載之組合物中,均未針對陰離子界面活性劑或非離子界面活性劑等之種類或含量等進行充分之研究,處於即便將該等組合物以泡狀應用於口腔內亦難以確保陽離子性殺菌劑之較高之吸附量之狀況。 However, in the composition described in any of the above documents, the type or content of an anionic surfactant, a nonionic surfactant, or the like is not sufficiently studied, and even if the compositions are applied in a bubble form, It is also difficult to ensure a high adsorption amount of the cationic bactericide in the oral cavity.
因此,本發明係關於一種藉由於使用時以泡狀應用於口腔內能夠有效地促進陽離子性殺菌劑於口腔內表面之吸附之液體口腔用組合物。 Accordingly, the present invention relates to a liquid oral composition capable of effectively promoting the adsorption of a cationic bactericide on the inner surface of the oral cavity by application to the oral cavity in a foam form during use.
因此,本發明者進行了各種研究,結果發現:藉由將作為陰離子界面活性劑之烷基硫酸鈉及陽離子性殺菌劑與水一併分別以特定量 及特定之質量比而含有,且對非離子界面活性劑之含量進行限制,可獲得一種能夠一面以泡狀應用於口腔內一面有效地促進陽離子性殺菌劑於口腔內表面之吸附之泡噴出容器裝之液體口腔用組合物。 Therefore, the inventors conducted various studies and found that a specific amount of sodium alkyl sulfate and a cationic bactericide as an anionic surfactant together with water were used. And a specific mass ratio, and limiting the content of the nonionic surfactant, a bubble ejecting container capable of effectively promoting the adsorption of the cationic bactericide on the inner surface of the oral cavity while being applied to the oral cavity in a bubble form is obtained. A liquid oral composition.
根據本發明,能夠於使用時以泡狀應用於口腔內,並且能夠有效地增大陽離子性殺菌劑於口腔內表面之吸附量。又,若為本發明,則作為以泡狀製劑為有效成分之陽離子性殺菌劑之口腔內表面吸附促進劑亦極為有用。 According to the present invention, it can be applied to the oral cavity in a foam form at the time of use, and the amount of adsorption of the cationic bactericidal agent on the inner surface of the oral cavity can be effectively increased. Moreover, in the present invention, an oral surface adsorption promoter which is a cationic bactericide which is an active ingredient in a foam preparation is also extremely useful.
以下,針對本發明詳細地進行說明。 Hereinafter, the present invention will be described in detail.
本發明之泡噴出容器裝之液體口腔用組合物含有烷基硫酸鈉0.05質量%以上且1質量%以下作為成分(A)。藉由以該量含有成分(A),能夠於自容器噴出時形成良好之泡,並且能夠有效地抑制後文所述之成分(B)之陽離子性殺菌劑於口腔內表面之吸附量之降低。 The liquid oral composition contained in the bubble ejecting container of the present invention contains 0.05% by mass or more and 1% by mass or less of sodium alkyl sulfate as the component (A). By containing the component (A) in an amount, it is possible to form a good bubble upon ejection from the container, and it is possible to effectively suppress the decrease in the amount of adsorption of the cationic bactericide on the inner surface of the oral cavity of the component (B) described later. .
作為該成分(A),例如可列舉具有碳數8~18之飽和或不飽和之烷基之烷基硫酸鈉,較佳為具有碳數10~16之飽和或不飽和之烷基之烷基硫酸鈉,較佳為具有碳數10~16之飽和烷基之烷基硫酸鈉,進而較佳為選自月桂基硫酸鈉、及肉豆蔻基硫酸鈉中之1種或2種,進而更佳為月桂基硫酸鈉。 The component (A) is, for example, a sodium alkyl sulfate having a saturated or unsaturated alkyl group having 8 to 18 carbon atoms, preferably an alkyl group having a saturated or unsaturated alkyl group having 10 to 16 carbon atoms. Sodium sulfate, preferably sodium alkyl sulfate having a saturated alkyl group having 10 to 16 carbon atoms, more preferably one or two selected from the group consisting of sodium lauryl sulfate and sodium myristyl sulfate, and further preferably It is sodium lauryl sulfate.
就於自容器噴出時形成良好之泡之觀點而言,成分(A)之含量於本發明之泡噴出容器裝之液體口腔用組合物中為0.05質量%以上,較佳為0.08質量%以上,更佳為0.1質量%以上。又,就有效地提高成分(B)之陽離子性殺菌劑於口腔內表面之吸附量之觀點而言,成分(A)之含量於本發明之泡噴出容器裝之液體口腔用組合物中為1質量%以下,較佳為0.7質量%以下,更佳為0.5質量%以下。並且,成分(A)之 含量於本發明之泡噴出容器裝之液體口腔用組合物中為0.05質量%以上且1質量%以下,較佳為0.08~0.7質量%,更佳為0.1~0.5質量%。 The content of the component (A) is 0.05% by mass or more, preferably 0.08% by mass or more, based on the liquid oral composition contained in the bubble ejecting container of the present invention, from the viewpoint of forming a good foam when the container is ejected. More preferably, it is 0.1% by mass or more. Further, from the viewpoint of effectively increasing the amount of adsorption of the cationic bactericide of the component (B) on the inner surface of the oral cavity, the content of the component (A) is 1 in the liquid oral composition of the blister container of the present invention. The mass% or less is preferably 0.7% by mass or less, more preferably 0.5% by mass or less. And, component (A) The content in the liquid oral composition contained in the bubble ejection container of the present invention is 0.05% by mass or more and 1% by mass or less, preferably 0.08% to 0.7% by mass, more preferably 0.1% to 0.5% by mass.
本發明之泡噴出容器裝之液體口腔用組合物含有陽離子性殺菌劑0.001質量%以上且0.1質量%以下作為成分(B)。若為本發明之泡噴出容器裝之液體口腔用組合物,則能夠使該量之成分(B)有效率地吸附於口腔內表面,而能夠對牙齦炎或牙周炎、或口臭之防止或預防帶來較高之效果。 The liquid oral composition contained in the bubble ejecting container of the present invention contains the cationic bactericide in an amount of 0.001% by mass or more and 0.1% by mass or less as the component (B). According to the liquid oral composition of the bubble ejection container of the present invention, the component (B) can be efficiently adsorbed to the inner surface of the oral cavity, and the gingivitis or periodontitis or the bad breath can be prevented or Prevention brings a higher effect.
作為該成分(B),例如可列舉四級銨化合物,具體而言,較佳為選自西吡氯銨(cetylpyridinium chloride)、及苄索氯銨(benzethonium chloride)中之1種或2種。 The component (B) is, for example, a quaternary ammonium compound. Specifically, it is preferably one or two selected from the group consisting of cetylpyridinium chloride and benzethonium chloride.
就確保於口腔內表面之吸附量之觀點而言,成分(B)之含量於本發明之泡噴出容器裝之液體口腔用組合物中為0.001質量%以上,較佳為0.005質量%以上,更佳為0.01質量%以上。又,就保持良好之使用感受之觀點而言,成分(B)之含量於本發明之泡噴出容器裝之液體口腔用組合物中為0.1質量%以下,較佳為0.07質量%以下,更佳為0.05質量%以下。並且,成分(B)之含量於本發明之泡噴出容器裝之液體口腔用組合物中為0.001質量%以上且0.1質量%以下,較佳為0.005~0.07質量%,更佳為0.01~0.05質量%。 The content of the component (B) is 0.001% by mass or more, preferably 0.005% by mass or more, more preferably 0.005% by mass or more, from the viewpoint of ensuring the amount of adsorption on the inner surface of the oral cavity in the liquid oral composition of the foam ejecting container of the present invention. Preferably, it is 0.01% by mass or more. In addition, the content of the component (B) is 0.1% by mass or less, preferably 0.07% by mass or less, more preferably 0.07% by mass or less, from the viewpoint of maintaining a good feeling of use. It is 0.05% by mass or less. Further, the content of the component (B) is 0.001% by mass or more and 0.1% by mass or less, preferably 0.005 to 0.07% by mass, more preferably 0.01 to 0.05% by mass in the liquid oral composition contained in the bubble ejection container of the present invention. %.
就提高成分(B)於口腔內表面之吸附量之觀點而言,成分(B)與成分(A)之質量比((B)/(A))為0.005以上,較佳為0.01以上,更佳為0.02以上。又,就於自容器噴出時形成良好之泡、提高泡之持續性、提高藉由泡而引起之成分(B)於口腔內表面之吸附量之觀點而言,成分(B)與成分(A)之質量比((B)/(A))為0.7以下,較佳為0.5以下,更佳為0.4以下,進而較佳為0.3以下。並且,成分(B)與成分(A)之質量比((B)/(A))為0.005~0.7,較佳為0.01~0.5,更佳為0.02~0.4,進而較佳為0.02~0.3。 The mass ratio ((B)/(A)) of the component (B) to the component (A) is 0.005 or more, preferably 0.01 or more, from the viewpoint of increasing the amount of adsorption of the component (B) on the inner surface of the oral cavity. Good is 0.02 or above. Further, in terms of forming a good bubble from the ejection of the container, improving the sustainability of the bubble, and improving the amount of adsorption of the component (B) on the inner surface of the oral cavity by the bubble, the component (B) and the component (A) The mass ratio ((B)/(A))) is 0.7 or less, preferably 0.5 or less, more preferably 0.4 or less, still more preferably 0.3 or less. Further, the mass ratio ((B)/(A)) of the component (B) to the component (A) is 0.005 to 0.7, preferably 0.01 to 0.5, more preferably 0.02 to 0.4, still more preferably 0.02 to 0.3.
本發明之泡噴出容器裝之液體口腔用組合物含有水作為成分(C)。所謂本發明中之成分(C)之水,意指不僅包含調配於泡噴出容器裝之液體口腔用組合物中之純化水或離子交換水等,亦包含所調配之各成分中所含之水分的含於液體口腔用組合物中之所有水分。藉由含有該成分(C)之水,能夠保持良好之保形性,且使各成分良好地分散或溶解而於口腔內良好地擴散,一面良好地包埋成分(B)一面形成泡。 The liquid oral composition contained in the bubble ejection container of the present invention contains water as the component (C). The water of the component (C) in the present invention means not only the purified water or ion-exchanged water or the like contained in the liquid oral composition contained in the bubble ejecting container, but also the moisture contained in the formulated components. All of the moisture contained in the liquid oral composition. By containing the water of the component (C), good shape retention property can be maintained, and each component can be well dispersed or dissolved to diffuse well in the oral cavity, and the component (B) can be favorably embedded to form a bubble.
就使各成分良好地分散或溶解之觀點、及良好之使用感受之觀點而言,成分(C)之含量於本發明之泡噴出容器裝之液體口腔用組合物中,較佳為55質量%以上,更佳為60質量%以上,進而較佳為65質量%以上。又,就形成良好之泡且保持自容器之噴出性之觀點、及提高成分(B)於口腔內表面之吸附性之觀點而言,成分(C)之含量於本發明之泡噴出容器裝之液體口腔用組合物中,較佳為99質量%以下,更佳為98.5質量%以下,進而較佳為98質量%以下。並且,成分(C)之含量於本發明之泡噴出容器裝之液體口腔用組合物中,較佳為55質量%以上且99質量%以下,更佳為60~98.5質量%,進而較佳為65~98質量%。 The content of the component (C) is preferably 55% by mass in the liquid oral composition of the bubble ejection container of the present invention, from the viewpoint of allowing the components to be well dispersed or dissolved, and the feeling of good use. The above is more preferably 60% by mass or more, and still more preferably 65% by mass or more. Further, from the viewpoint of forming a good foam and maintaining the discharge property from the container, and improving the adsorption property of the component (B) on the inner surface of the oral cavity, the content of the component (C) is contained in the bubble ejection container of the present invention. The liquid oral composition is preferably 99% by mass or less, more preferably 98.5% by mass or less, still more preferably 98% by mass or less. Further, the content of the component (C) is preferably 55 mass% or more and 99 mass% or less, more preferably 60 to 98. mass%, more preferably 60 to 98. mass%, more preferably in the liquid oral composition of the bubble spray container of the present invention. 65 to 98% by mass.
就於自容器噴出時形成良好之泡之觀點而言,成分(A)與成分(C)之質量比((A)/(C))較佳為0.05×10-2以上,更佳為0.07×10-2以上,進而較佳為0.08×10-2以上,進而更佳為0.1×10-2以上。又,就使各成分良好地分散或溶解而於口腔內良好地擴散之觀點而言,成分(A)與成分(C)之質量比((A)/(C))較佳為1.5×10-2以下,更佳為1.2×10-2以下,進而較佳為1×10-2以下,進而更佳為0.8×10-2以下,進而更佳為0.65×10-2以下。並且,成分(A)與成分(C)之質量比((A)/(C))較佳為0.05×10-2~1.5×10-2,更佳為0.07×10-2~1.2×10-2,進而較佳為0.08×10-2~1×10-2,進而更佳為0.1×10-2~0.8×10-2,進而更佳為0.1×10-2~0.65×10-2。 The mass ratio ((A)/(C)) of the component (A) to the component (C) is preferably 0.05 × 10 -2 or more, more preferably 0.07, from the viewpoint of forming a good bubble from the ejection of the container. ×10 -2 or more, further preferably 0.08 × 10 -2 or more, and still more preferably 0.1 × 10 -2 or more. Further, the mass ratio ((A)/(C)) of the component (A) to the component (C) is preferably 1.5 × 10 from the viewpoint of dispersing or dissolving each component well and diffusing well in the oral cavity. It is -2 or less, more preferably 1.2 × 10 -2 or less, further preferably 1 × 10 -2 or less, further preferably 0.8 × 10 -2 or less, and still more preferably 0.65 × 10 -2 or less. Further, the mass ratio ((A)/(C)) of the component (A) to the component (C) is preferably 0.05 × 10 -2 to 1.5 × 10 -2 , more preferably 0.07 × 10 -2 to 1.2 × 10 -2, and further preferably 0.08 × 10 -2 ~ 1 × 10 -2, and further more preferably 0.1 × 10 -2 ~ 0.8 × 10 -2, and further more preferably 0.1 × 10 -2 ~ 0.65 × 10 -2 .
就於自容器噴出時形成良好之泡之觀點而言,成分(B)與成分(C)之質量比((B)/(C))較佳為0.05×10-3以上,更佳為0.07×10-3以上,進而較佳為0.08×10-3以上,進而更佳為0.1×10-3以上。又,就使各成分良好地分散或溶解而於口腔內良好地擴散之觀點而言,成分(B)與成分(C)之質量比((B)/(C))較佳為1×10-3以下,更佳為0.8×10-3以下,進而較佳為0.7×10-3以下,進而更佳為0.6×10-3以下。並且,成分(B)與成分(C)之質量比((B)/(C))較佳為0.05×10-3~1×10-3,更佳為0.07×10-3~0.8×10-3,進而較佳為0.08×10-3~0.7×10-3,進而更佳為0.1×10-3~0.6×10-3。 The mass ratio ((B)/(C)) of the component (B) to the component (C) is preferably 0.05 × 10 -3 or more, more preferably 0.07, from the viewpoint of forming a good bubble from the ejection of the container. ×10 -3 or more, further preferably 0.08 × 10 -3 or more, and still more preferably 0.1 × 10 -3 or more. Further, the mass ratio ((B)/(C)) of the component (B) to the component (C) is preferably 1 × 10 from the viewpoint that the components are well dispersed or dissolved and diffused well in the oral cavity. It is -3 or less, more preferably 0.8 × 10 -3 or less, further preferably 0.7 × 10 -3 or less, and still more preferably 0.6 × 10 -3 or less. Further, the mass ratio of the component (B) to the component (C) ((B)/(C)) is preferably 0.05 × 10 -3 to 1 × 10 -3 , more preferably 0.07 × 10 -3 to 0.8 × 10 -3, further preferably 0.08 × 10 -3 ~ 0.7 × 10 -3, and further more preferably 0.1 × 10 -3 ~ 0.6 × 10 -3.
本發明之泡噴出容器裝之液體口腔用組合物中,非離子界面活性劑之含量為1.2質量%以下。藉由如此地對非離子界面活性劑之含有進行限制,能夠確保自容器噴出時之良好之泡之形成,且有效地促進成分(B)於口腔內表面之吸附。作為該非離子界面活性劑,例如可列舉選自聚氧乙烯氫化蓖麻油、蔗糖脂肪酸酯;山梨糖醇酐脂肪酸酯;甘油單硬脂酸酯、甘油單油酸酯等甘油脂肪酸酯;烷基葡糖苷;聚氧乙烯單烷基(或烯基)醚、聚氧乙烯聚氧丙烯共聚物等聚氧乙烯烷基醚;聚氧乙烯壬基苯醚等聚氧乙烯苯醚;氧化胺系界面活性劑;單-(或二-)乙醇醯胺、椰子油脂肪酸二乙醇醯胺等脂肪酸烷醇醯胺;聚甘油-10硬脂酸酯、聚甘油-10月桂酸酯、聚甘油-10油酸酯等聚甘油脂肪酸酯;以及聚乙烯聚丙二醇等聚二醇中之1種或2種以上。其中,作為可使用之非離子界面活性劑,較佳為選自聚氧乙烯氫化蓖麻油、蔗糖脂肪酸酯、山梨糖醇酐脂肪酸酯、及聚甘油脂肪酸酯中之1種或2種以上。 In the liquid oral composition of the bubble jet container of the present invention, the content of the nonionic surfactant is 1.2% by mass or less. By restricting the content of the nonionic surfactant in this manner, it is possible to ensure the formation of a good bubble at the time of ejection from the container, and to effectively promote the adsorption of the component (B) on the inner surface of the oral cavity. Examples of the nonionic surfactant include polyoxyethylene hydrogenated castor oil, sucrose fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester such as glycerin monostearate or glycerol monooleate; Alkyl glucoside; polyoxyethylene alkyl ether such as polyoxyethylene monoalkyl (or alkenyl) ether, polyoxyethylene polyoxypropylene copolymer; polyoxyethylene phenyl ether such as polyoxyethylene nonylphenyl ether; amine oxide Surfactant; mono-(or di-)ethanolamine, coconut oil fatty acid diethanolamine, and other fatty acid alkanolamines; polyglyceryl-10 stearate, polyglycerol-10 laurate, polyglycerol- One or two or more kinds of polyglycerol fatty acid esters such as oleic acid ester; and polyglycols such as polyethylene polypropylene glycol. Among them, as the usable nonionic surfactant, one or two selected from the group consisting of polyoxyethylene hydrogenated castor oil, sucrose fatty acid ester, sorbitan fatty acid ester, and polyglycerin fatty acid ester are preferable. the above.
就保持良好之噴出性且提高成分(B)於口腔內表面之吸附性之觀點而言,非離子界面活性劑之含量於本發明之泡噴出容器裝之液體口腔用組合物中為1.2質量%以下,較佳為1質量%以下,更佳為0.8質量 %以下,進而較佳為0.5質量%以下,進而更佳為0.2質量%以下,或者本發明之泡噴出容器裝之液體口腔用組合物亦可不含有非離子界面活性劑。 The content of the nonionic surfactant is 1.2% by mass in the liquid oral composition of the bubble ejection container of the present invention from the viewpoint of maintaining good ejection properties and improving the adsorption of the component (B) on the inner surface of the oral cavity. Hereinafter, it is preferably 1% by mass or less, more preferably 0.8% by mass. % or less, further preferably 0.5% by mass or less, more preferably 0.2% by mass or less, or the liquid oral composition contained in the bubble jet container of the present invention may not contain a nonionic surfactant.
就有效地抑制成分(B)於口腔內表面之吸附量減少之觀點而言,非離子界面活性劑與成分(B)之質量比(非離子界面活性劑/(B))較佳為100以下,更佳為50以下,進而較佳為20以下,進而更佳為10以下。 The mass ratio of the nonionic surfactant to the component (B) (nonionic surfactant/(B)) is preferably 100 or less from the viewpoint of effectively suppressing the decrease in the amount of adsorption of the component (B) on the inner surface of the oral cavity. More preferably, it is 50 or less, further preferably 20 or less, and still more preferably 10 or less.
關於本發明之泡噴出容器裝之液體口腔用組合物,就確保泡之保持性之觀點而言,於本發明之泡噴出容器裝之液體口腔用組合物中,乙醇之含量較佳為2.7質量%以下,更佳為2.5質量%以下,進而較佳為2.2質量%以下,進而更佳為2質量%以下,且較佳為超過0質量%,較佳為1質量%以上。又,乙醇之含量於本發明之泡噴出容器裝之液體口腔用組合物中,較佳為2.7質量%以下,更佳為0~2.7質量%,進而較佳為0~2.5質量%,進而更佳為0~2.2質量%,特佳為0~2質量%,且較佳為超過0質量%且2.7質量%以下,更佳為1~2.5質量%,進而較佳為1~2.2質量%,特佳為1~2質量%。 With respect to the liquid oral composition of the bubble ejecting container of the present invention, in the liquid oral composition of the bubble ejecting container of the present invention, the content of ethanol is preferably 2.7 by mass in terms of ensuring the retention of the foam. % or less is more preferably 2.5% by mass or less, further preferably 2.2% by mass or less, further preferably 2% by mass or less, and more preferably 0% by mass or more, and preferably 1% by mass or more. Further, the content of the ethanol is preferably 2.7 mass% or less, more preferably 0 to 2.7% by mass, still more preferably 0 to 2.5% by mass, and further preferably 0 to 2.5% by mass, and more preferably the liquid oral composition contained in the bubble ejecting container of the present invention. Preferably, it is 0 to 2.2% by mass, particularly preferably 0 to 2% by mass, and more preferably more than 0% by mass and 2.7% by mass or less, more preferably 1 to 2.5% by mass, still more preferably 1 to 2.2% by mass, Particularly preferred is 1 to 2% by mass.
又,就確保各成分之溶解性或分散性且於自容器噴出時表現良好之泡質之觀點而言,乙醇與非離子界面活性劑之合計含量於本發明之泡噴出容器裝之液體口腔用組合物中,較佳為3質量%以下,更佳為2.7質量%以下,進而較佳為2.5質量%以下,進而更佳為2.2質量%以下,特佳為2質量%以下。 Further, from the viewpoint of ensuring the solubility or dispersibility of each component and the foam quality which is excellent when ejected from the container, the total content of the ethanol and the nonionic surfactant is in the liquid oral cavity of the bubble ejecting container of the present invention. The composition is preferably 3% by mass or less, more preferably 2.7% by mass or less, still more preferably 2.5% by mass or less, still more preferably 2.2% by mass or less, and particularly preferably 2% by mass or less.
關於本發明之泡噴出容器裝之液體口腔用組合物,就確保自容器之良好之噴出性之觀點而言,較佳為於本發明之泡噴出容器裝之液體口腔用組合物中,研磨性粉體之含量為0.5質量%以下,更佳為0.4質量%以下,進而較佳為0.3質量%以下,又,進而較佳為0.2質量%以下,且較佳為超過0質量%,或者本發明之泡噴出容器裝之液體口腔用組合物較佳為不含有研磨性粉體。又,研磨性粉體之含量於本發明 之泡噴出容器裝之液體口腔用組合物中,較佳為0.5質量%以下,更佳為0~0.4質量%,進而較佳為0~0.3質量%,又,進而較佳為0~0.2質量%,或者本發明之泡噴出容器裝之液體口腔用組合物較佳為不含有研磨性粉體。 The liquid oral composition contained in the bubble ejecting container of the present invention is preferably in the liquid oral composition contained in the bubble ejecting container of the present invention from the viewpoint of ensuring good discharge property from the container. The content of the powder is 0.5% by mass or less, more preferably 0.4% by mass or less, further preferably 0.3% by mass or less, further preferably 0.2% by mass or less, and more preferably 0% by mass or the present invention. The liquid oral composition contained in the bubble ejection container preferably does not contain an abrasive powder. Moreover, the content of the abrasive powder is in the present invention. The liquid oral composition contained in the bubble ejecting container is preferably 0.5% by mass or less, more preferably 0 to 0.4% by mass, still more preferably 0 to 0.3% by mass, and still more preferably 0 to 0.2% by mass. %, or the liquid oral composition contained in the bubble ejecting container of the present invention preferably does not contain an abrasive powder.
作為該研磨性粉體,例如可列舉選自輕質碳酸鈣、重質碳酸鈣、沸石、吸油量為50~150mL/100g之研磨性二氧化矽、磷酸二鈣、磷酸三鈣、不溶性偏磷酸鈉、氫氧化鋁、磷酸鎂、焦磷酸鈣、及碳酸鎂等中之1種或2種以上。 Examples of the abrasive powder include light calcium carbonate, heavy calcium carbonate, zeolite, abrasive cerium oxide having an oil absorption of 50 to 150 mL/100 g, dicalcium phosphate, tricalcium phosphate, and insoluble metaphosphoric acid. One or more of sodium, aluminum hydroxide, magnesium phosphate, calcium pyrophosphate, and magnesium carbonate.
再者,所謂吸油量,係表示二氧化矽能夠擔載之油量,測定方法係藉由基於JIS K5101-13-2(2004年制定)之方法,根據所吸收之熟亞麻仁油之量進行特定。 In addition, the amount of oil absorption is the amount of oil that can be carried by cerium oxide, and the measurement method is based on the amount of cooked linseed oil absorbed by a method based on JIS K5101-13-2 (2004). specific.
就防止自容器噴出時按壓不必要地變高之觀點、及有效地防止因於泡噴出容器之多孔質構件產生組合物之附著而引起之於多孔質構件之孔堵塞從而確保優異之噴出性之觀點而言,本發明之泡噴出容器裝之液體口腔用組合物較佳為對在20℃下為固體之糖醇之含量進行限制。作為該於20℃下為固體之糖醇,例如可列舉山梨糖醇、木糖醇、赤藻糖醇、甘露糖醇、異麥芽酮糖醇等。 From the viewpoint of preventing the pressing from being unnecessarily high when the container is ejected, and effectively preventing the clogging of the pores of the porous member due to the adhesion of the composition due to the porous member of the bubble ejecting container, the excellent ejection property is ensured. In view of the above, the liquid oral composition of the bubble ejecting container of the present invention preferably limits the content of the sugar alcohol which is solid at 20 °C. Examples of the sugar alcohol which is solid at 20 ° C include sorbitol, xylitol, erythritol, mannitol, isomalt, and the like.
於20℃下為固體之糖醇之含量於本發明之泡噴出容器裝之液體口腔用組合物中,較佳為1質量%以下,更佳為0.5質量%以下,進而較佳為0.1質量%以下,進而更佳為0.05質量%以下,或者本發明之泡噴出容器裝之液體口腔用組合物較佳為不含有於20℃下為固體之糖醇。 The content of the solid sugar alcohol at 20 ° C is preferably 1% by mass or less, more preferably 0.5% by mass or less, still more preferably 0.1% by mass, based on the liquid oral composition contained in the bubble spray container of the present invention. In the following, it is more preferably 0.05% by mass or less, or the liquid oral composition contained in the bubble ejecting container of the present invention preferably does not contain a sugar alcohol which is solid at 20 °C.
就於自容器噴出時形成良好之泡之觀點、確保泡之保持性之觀點、及保持良好之香味之觀點而言,本發明之泡噴出容器裝之液體口腔用組合物較佳為對水溶性之多價金屬鹽之含量進行限制。作為該水溶性之多價金屬鹽,可列舉:氧化鈣、氫氧化鈣、氯化鈣、硫酸鈣、 焦磷酸鈣、硬脂酸鈣、泛酸鈣等鈣鹽;乳酸鋁、氯羥基鋁、尿囊素羥基鋁、尿囊素氯羥基鋁、尿囊素二羥基鋁、對苯酚磺酸鋁、氯化鋁、明礬(硫酸鉀鋁十二水合物)、鈉明礬(硫酸鈉鋁十二水合物)硝酸鋁等鋁鹽;對苯酚磺酸鋅鹽、氯化鋅、葡萄糖酸鋅、乙酸鋅、硫酸鋅等鋅鹽;葡萄糖酸鎂、硫酸鎂、氯化鎂等鎂鹽。再者,所謂水溶性之多價金屬鹽,意指於水中會釋出多價金屬離子之鹽,具體而言,水溶性之多價金屬鹽相對於20℃下之水100g之溶解量較佳為0.1g以上,更佳為0.5g以上。 The liquid oral composition of the bubble spray container of the present invention is preferably water-soluble from the viewpoint of forming a good bubble at the time of ejection from the container, the viewpoint of ensuring the retention of the bubble, and the viewpoint of maintaining a good fragrance. The content of the polyvalent metal salt is limited. Examples of the water-soluble polyvalent metal salt include calcium oxide, calcium hydroxide, calcium chloride, and calcium sulfate. Calcium phosphate, calcium stearate, calcium pantothenate, etc.; aluminum lactate, chlorohydroxy aluminum, allantoin hydroxy aluminum, allantoin chlorohydroxy aluminum, allantoin dihydroxy aluminum, p-phenol sulfonate, chlorination Aluminum salts such as aluminum, alum (potassium sulfate aluminum dodecahydrate), sodium alum (sodium sulfate aluminum dodecahydrate) aluminum nitrate; zinc phenolsulfonate, zinc chloride, zinc gluconate, zinc acetate, zinc sulfate Such as zinc salt; magnesium gluconate, magnesium sulfate, magnesium chloride and other magnesium salts. Further, the water-soluble polyvalent metal salt means that a salt of a polyvalent metal ion is released in water, and specifically, a water-soluble polyvalent metal salt is preferably dissolved in 100 g of water at 20 ° C. It is 0.1 g or more, more preferably 0.5 g or more.
該水溶性之多價金屬鹽之金屬原子換算量以與成分(A)之質量比(多價金屬/(A))計,較佳為0.1以下,更佳為0.01以下,進而較佳為0.005以下,進而較佳為0.001以下。又,該水溶性之多價金屬鹽之含量以金屬原子換算量計,於本發明之泡噴出容器裝之液體口腔用組合物中,較佳為0.1質量%以下,更佳為0.005質量%以下,進而較佳為0.001質量%以下,或者本發明之泡噴出容器裝之液體口腔用組合物較佳為不含有水溶性之多價金屬鹽。 The amount of the metal atom of the water-soluble polyvalent metal salt is preferably 0.1 or less, more preferably 0.01 or less, still more preferably 0.005, based on the mass ratio of the component (A) (polyvalent metal/(A)). Hereinafter, it is more preferably 0.001 or less. In addition, the content of the water-soluble polyvalent metal salt is preferably 0.1% by mass or less, more preferably 0.005% by mass or less, based on the metal atom, in the liquid oral composition of the bubble jet container of the present invention. Further, it is preferably 0.001% by mass or less, or the liquid oral composition contained in the bubble ejecting container of the present invention preferably contains no water-soluble polyvalent metal salt.
就於自容器噴出時形成良好之泡且保持良好之香味之觀點而言,本發明之泡噴出容器裝之液體口腔用組合物較佳為對檸檬酸之含量進行限制。該檸檬酸之含量於本發明之泡噴出容器裝之液體口腔用組合物中,較佳為0.08質量%以下,更佳為0.05質量%以下,或者本發明之泡噴出容器裝之液體口腔用組合物較佳為限於含有檸檬酸鈉之情形時含有檸檬酸。 The liquid oral composition of the bubble spray container of the present invention preferably limits the content of citric acid from the viewpoint of forming a good bubble from the ejection of the container and maintaining a good fragrance. The content of the citric acid is preferably 0.08% by mass or less, more preferably 0.05% by mass or less, based on the liquid oral composition contained in the bubble ejecting container of the present invention, or the liquid oral composition of the bubble ejecting container of the present invention. Preferably, the material is limited to contain citric acid in the case of sodium citrate.
本發明之泡噴出容器裝之液體口腔用組合物可於不阻礙本發明之效果之範圍內,除上述成分以外還含有例如上述成分(A)之烷基硫酸鈉及非離子界面活性劑以外之界面活性劑、香料、防腐劑、黏結劑、顏料、色素等。 The liquid oral composition contained in the bubble ejecting container of the present invention may contain, in addition to the above components, a sodium alkyl sulfate of the above component (A) and a nonionic surfactant, in addition to the above components. Surfactants, perfumes, preservatives, binders, pigments, pigments, etc.
作為上述成分(A)之烷基硫酸鈉及非離子界面活性劑以外之界面 活性劑,可列舉兩性界面活性劑,作為該兩性界面活性劑,具體而言,可列舉:月桂基二甲基胺基乙酸甜菜鹼等乙酸甜菜鹼;2-烷基-N-羧基甲基-N-羥基乙基-N-咪唑鎓甜菜鹼等咪唑啉鎓甜菜鹼;月桂基磺基甜菜鹼或月桂基羥基磺基甜菜鹼等烷基磺基甜菜鹼;椰子油脂肪醯胺丙基甜菜鹼等椰子油脂肪醯胺烷基甜菜鹼;N-烷基-1-羥基乙基咪唑啉甜菜鹼鈉等長鏈烷基咪唑啉甜菜鹼鹽。 As an interface other than the sodium alkyl sulfate and the nonionic surfactant of the above component (A) The active agent may, for example, be an amphoteric surfactant. Specific examples of the amphoteric surfactant include acetic acid betaine such as lauryl dimethylaminoacetate betaine; 2-alkyl-N-carboxymethyl- Imidazolinium betaine such as N-hydroxyethyl-N-imidazolium betaine; alkylsulfobetaine such as lauryl sulfobetaine or lauryl hydroxysultaine; coconut fatty amidamine propyl betaine Such as coconut oil fatty guanamine alkyl betaines; N-alkyl-1-hydroxyethyl imidazoline betaine sodium and other long-chain alkyl imidazolinium betaine.
再者,就有效地提高成分(B)之陽離子性殺菌劑於口腔內表面之吸附量之觀點、及味道之觀點而言,該等兩性界面活性劑之含量於本發明之泡噴出容器裝之液體口腔用組合物中,較佳為未達0.2質量%,更佳為0.15質量%以下。 Further, in terms of effectively increasing the amount of the cationic bactericide of the component (B) adsorbed on the inner surface of the oral cavity, and the taste, the content of the amphoteric surfactant is contained in the blister container of the present invention. The liquid oral composition is preferably less than 0.2% by mass, more preferably 0.15% by mass or less.
作為香料,只要為呈油溶性之香料即可,例如可列舉:胡椒薄荷油(peppermint oil)、綠薄荷油、錫蘭肉桂油(cinnamon oil)、大茴香油、桉葉油、冬青油、肉桂油(cassia oil)、丁香油、麝香草油、鼠尾草油(sage oil)、香紫蘇油(sage clary oil)、肉豆蔻油、茴香油、檸檬油、甜橙油、薄荷油、小豆蔻油、原荽子油、羅勒油、紅橘油、萊姆油、熏衣草油、迷迭香油、薑油、葡萄柚油、月桂油(laurel oil)、黃金菊油(chamomile oil)、葛縷子油(caraway oil)、馬郁蘭油、香葉油(bay oil)、檸檬草油、檸檬薄荷油(lemon balm oil)、多香果油(pimento berry oil)、玫瑰草油、乳香油、松針油(pine needle oil)、卑檸油(petitgrain oil)、橙花油、玫瑰油、茉莉油等天然香料成分、及對該等天然香料成分進行加工處理而成之香料成分;薄荷腦、長葉薄荷醇、香芹酮、大茴香腦、桉樹腦(cineole)、水楊酸甲酯、桂皮醛、丁香酚、3-1-薄荷氧基丙烷-1,2-二醇、瑞香草酚(thymol)、乙酸香茅酯、沈香醇、乙酸沈香酯、香葉草醇、乙酸香葉酯、香茅醇、檸檬烯、薄荷酮、乙酸薄荷酯、N-取代-對薄荷烷-3-甲醯胺、蒎烯、辛醛、檸檬醛、蒲勒酮、乙酸香芹酯、乙酸二氫香芹酯、大茴香醛 (anisaldehyde)、苯甲醛、樟腦、內酯、乙酸乙酯、丁酸乙酯、環己基丙酸烯丙酯、鄰胺苯甲酸甲酯、甲基苯基縮水甘油酸乙酯、香蘭素、十一酸內酯、己醛、乙酸丁酯、乙酸異戊酯、己烯醇、二甲硫醚、甲基環戊烯醇酮(cyclotene)、糠醛、三甲基吡、乳酸乙酯、乳酸甲酯、硫代乙酸乙酯等單香料成分;草莓香料、蘋果香料、香蕉香料、鳳梨香料、葡萄香料、芒果香料、奶油香料、牛乳香料、水果混合香料、熱帶水果香料等調製香料成分。 The fragrance may be an oil-soluble fragrance, and examples thereof include peppermint oil, spearmint oil, cinnamon oil, anise oil, eucalyptus oil, wintergreen oil, and cinnamon. Cassia oil, clove oil, thyme oil, sage oil, sage clary oil, nutmeg oil, fennel oil, lemon oil, orange oil, peppermint oil, cardamom Oil, raw hazelnut oil, basil oil, red orange oil, lime oil, lavender oil, rosemary oil, ginger oil, grapefruit oil, laurel oil, chamomile oil, ge Caraway oil, marjoram oil, bay oil, lemongrass oil, lemon balm oil, pimento berry oil, rose grass oil, mastic oil, pine needle Natural flavor ingredients such as pine needle oil, petitgrain oil, neroli oil, rose oil, jasmine oil, and flavoring ingredients obtained by processing the natural flavor components; menthol, long leaves Menthol, carvone, aniseed brain, cineole, methyl salicylate, cinnamon , eugenol, 3-1-menthyloxypropane-1,2-diol, thymol, citronellyl acetate, linalool, acetoacetate, geranyl alcohol, geranyl acetate, fragrant Molly, limonene, menthone, menthyl acetate, N-substituted-p-menthan-3-carboxamide, decene, octanal, citral, purlerone, carboxyl acetate, dihydrocarvyl acetate , anisaldehyde, benzaldehyde, camphor, lactone, ethyl acetate, ethyl butyrate, allyl cyclohexyl propionate, methyl ortho-benzoate, ethyl methyl phenyl glycidate, Vanillin, undecanoate, hexanal, butyl acetate, isoamyl acetate, hexenol, dimethyl sulfide, cyclocyclopentene, furfural, trimethylpyridinium , single ester ingredients such as ethyl lactate, methyl lactate, and ethyl thioacetate; strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, cream flavor, milk flavor, fruit blend flavor, tropical fruit flavor And so on to prepare the flavor component.
作為防腐劑,例如可列舉:對羥基苯甲酸異丁酯、對羥基苯甲酸異丙酯、對羥基苯甲酸乙酯、對羥基苯甲酸丁酯、對羥基苯甲酸丙酯、對羥基苯甲酸甲酯、苯甲酸、苯甲酸鈉、水楊酸甲酯、山梨酸鉀、脫氫乙酸鈉。 Examples of the preservative include isobutyl p-hydroxybenzoate, isopropyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, butyl p-hydroxybenzoate, propyl p-hydroxybenzoate, and p-hydroxybenzoate. Ester, benzoic acid, sodium benzoate, methyl salicylate, potassium sorbate, sodium dehydroacetate.
作為黏結劑,可列舉:海藻酸鈉、羧甲基纖維素鈉、鹿角菜膠、三仙膠、聚丙烯酸鈉、羥乙基纖維素、羥丙基纖維素、果膠、黃耆膠、阿拉伯膠、瓜爾膠、刺梧桐樹膠、刺槐豆膠、結冷膠、羅望子膠、洋車前子籽膠(psyllium seed gum)、聚乙烯醇、硫酸軟骨素鈉、甲氧基乙烯-順丁烯二酸酐共聚物,較佳為選自羧甲基纖維素鈉、鹿角菜膠、三仙膠、羥乙基纖維素中之1種或2種以上。就自泡噴出容器之適度之噴出壓之觀點而言,該黏結劑之含量於本發明之泡噴出容器裝之液體口腔用組合物中,較佳為0.5質量%以下,更佳為0.3質量%以下。 Examples of the binder include sodium alginate, sodium carboxymethylcellulose, carrageenan, sanmon gum, sodium polyacrylate, hydroxyethylcellulose, hydroxypropylcellulose, pectin, tragacanth, and arabic. Gum, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, sodium chondroitin sulfate, methoxyethylene-cis-butyl The enedionic acid anhydride copolymer is preferably one or more selected from the group consisting of sodium carboxymethyl cellulose, carrageenan, triterpene, and hydroxyethyl cellulose. The content of the binder in the liquid oral composition of the bubble jet container of the present invention is preferably 0.5% by mass or less, more preferably 0.3% by mass, from the viewpoint of a moderate discharge pressure from the bubble ejecting container. the following.
就於自容器噴出時形成良好之泡且防止刺激之觀點而言,本發明之液體口腔用組合物於25℃下之pH值較佳為3以上,就進一步減少異味或刺激之觀點而言,較佳為5以上,更佳為6以上,進而較佳為7以上,且較佳為11.5以下,更佳為11以下,進而較佳為10.8以下。 The liquid oral composition of the present invention preferably has a pH of at least 3 at 25 ° C from the viewpoint of forming a good foam from the ejection of the container and preventing irritation, and further reduces odor or irritation. It is preferably 5 or more, more preferably 6 or more, still more preferably 7 or more, and is preferably 11.5 or less, more preferably 11 or less, still more preferably 10.8 or less.
再者,亦可於將本發明之液體口腔用組合物於25℃下之pH值調整為上述範圍之方面使用pH值調整劑。作為該pH值調整劑,可列舉 選自碳酸鹽或重碳酸鹽;氫氧化鉀或氫氧化鈉;檸檬酸、蘋果酸、乳酸、酒石酸、琥珀酸等有機酸或該等之鹽中之1種或2種以上,此處,於使用有機酸之情形時,較佳為與有機酸鈉一起併用,且較佳為如上述般對該檸檬酸之含量進行限制。或者於使用檸檬酸之情形時,較佳為與檸檬酸鈉一起併用。 Further, a pH adjusting agent may be used in that the pH of the liquid oral composition of the present invention is adjusted to the above range at 25 ° C. As the pH adjuster, It is selected from the group consisting of a carbonate or a bicarbonate; potassium hydroxide or sodium hydroxide; an organic acid such as citric acid, malic acid, lactic acid, tartaric acid or succinic acid; or one or more of these salts, here, In the case of using an organic acid, it is preferably used in combination with sodium acidate, and it is preferred to limit the content of the citric acid as described above. Or in the case of using citric acid, it is preferably used together with sodium citrate.
本發明之泡噴出容器裝之液體口腔用組合物係填充於具備噴出口之泡噴出容器而成。於使用本發明之泡噴出容器裝之液體口腔用組合物時,將作為內容物之上述液體口腔用組合物自泡噴出容器所具備之噴出口直接噴出至口腔內,而將經由噴出口之液體口腔用組合物以泡狀應用於口腔內。藉此,能夠藉由帶來良好之泡質而一面實際感受優異之使用感受,一面使上述液體口腔用組合物遍及至口腔內之各個角落,並且能夠有效地提高成分(B)之陽離子性殺菌劑於口腔內表面之吸附性。 The liquid oral composition contained in the bubble discharge container of the present invention is filled in a bubble discharge container having a discharge port. When the liquid oral composition contained in the bubble ejecting container of the present invention is used, the liquid oral composition as a content is directly ejected into the oral cavity from the ejection port provided in the ejecting container, and the liquid is discharged through the ejection port. The oral composition is applied to the oral cavity in a foam form. Thereby, the liquid oral composition can be spread to various corners of the oral cavity while bringing a good foam quality, and the cationic disinfection of the component (B) can be effectively improved. The adsorption of the agent on the inner surface of the oral cavity.
作為填充上述液體口腔用組合物之泡噴出容器,只要為具備噴出口者即可,就噴出量之控制之容易性及泡質控制之觀點而言,較佳為非氣溶膠型容器,就細小之泡性能及壓縮氣體之效力之觀點而言,較佳為氣溶膠型容器。 The bubble discharge container which fills the liquid oral composition is preferably a non-aerosol type container as long as it is provided with a discharge port, and is preferably a non-aerosol type container from the viewpoint of easiness of control of discharge amount and control of foam quality. From the viewpoint of the foaming performance and the effectiveness of the compressed gas, an aerosol type container is preferred.
所謂非氣溶膠型容器,係不需要壓縮氣體等噴射劑之常壓容器,作為該容器,例如可列舉擠壓式容器及泵式容器。就於內容物經由噴出口時良好地形成泡狀之組合物之觀點、及所形成之泡具有良好之保持性或均質性而將使用感受等提高等觀點而言,該等容器均較佳為於自容器本體直至噴出口為止之內容物之流路中介存篩網或設置有複數個小孔之多孔質構件而成之容器。 The non-aerosol type container is an atmospheric container which does not require a propellant such as a compressed gas, and examples of the container include a squeeze type container and a pump type container. These containers are preferably used in view of the fact that the content of the content is well formed into a bubble-like composition through the discharge port, and that the formed bubble has good retention or homogeneity, and the feeling of use is improved. The flow path of the contents from the container body to the discharge port is a container in which a sieve or a porous member provided with a plurality of small holes is interposed.
所謂擠壓式容器,係藉由使位於可變形之容器本體之主體部擠壓變形,使自頂部空間內壓送之空氣與內容物一面視需要經由多孔質構件一面進行混合而形成泡並使該泡自噴出口噴出者。具體而言,例 如可使用日本專利特開平7-215352號公報、日本實用新型實開昭58-174272號公報、及日本實用新型實開昭62-42787號公報中記載之容器等。 The squeeze container is formed by squeezing and deforming the main body portion of the deformable container body so that the air and the contents which are fed from the head space are mixed through the porous member as needed, thereby forming a bubble and The bubble is ejected from the ejection outlet. Specifically, an example For example, a container described in Japanese Laid-Open Patent Publication No. Hei. No. Hei. No. Hei. No. Hei. No. Hei.
所謂泵式容器,係藉由壓入具有噴出口之泡噴出器所具備之泵頭,使自外部流入之空氣與內容物一面視需要經由多孔質構件一面進行混合而形成泡並使該泡自噴出口噴出者。通常,具備用以使空氣自外部流入之空氣筒、及成為內容物之流路之液筒,並且具備用以使藉由泵頭之壓入所壓送之空氣與內容物混合之混合室。具體而言,例如可使用日本專利特開平7-315463號公報、日本專利特開平8-230961號公報、及日本實用新型實開平3-7963號公報中記載之容器等。 In the pump type container, the pump head provided in the bubble ejector having the discharge port is configured to mix the air and the contents flowing in from the outside through the porous member as needed, thereby forming a bubble and causing the bubble to be sprayed. Export spouter. Usually, an air cylinder for allowing air to flow in from the outside and a liquid cylinder to be a flow path of the contents are provided, and a mixing chamber for mixing the air pumped by the pump head and the contents is provided. Specifically, for example, a container described in Japanese Laid-Open Patent Publication No. Hei. No. Hei. No. Hei.
所謂氣溶膠型容器,係填充壓縮氣體作為噴射劑而成之容器,且於自噴出口噴出內容物時,一面經由閥機構引入氣體一面形成泡。作為所使用之壓縮氣體,較佳為含有二氧化碳90質量%以上之氣體。 The aerosol-type container is a container in which a compressed gas is filled as a propellant, and when a content is discharged from a discharge port, a bubble is formed while introducing a gas through a valve mechanism. As the compressed gas to be used, a gas containing 90% by mass or more of carbon dioxide is preferable.
作為本發明中使用之泡噴出容器,就使用性之觀點、即容易自噴出口向口腔內直接噴出內容物之觀點而言,較佳為擠壓式容器或泵式容器之非氣溶膠容器、或為氣溶膠容器,就泡性能之觀點而言,較佳為泵式容器,就泡性能及方便性或攜帶性亦優異之觀點而言,更佳為擠壓容器,進而較佳為於自容器本體直至噴出口為止之內容物之流路中具備#90~#305之篩網之擠壓容器。 The bubble ejecting container used in the present invention is preferably a non-aerosol container of a squeeze container or a pump container, from the viewpoint of usability, that is, a product which is easily ejected directly into the oral cavity from the ejection port, or The aerosol container is preferably a pump container from the viewpoint of foam performance, and is preferably a squeeze container, and more preferably a container, from the viewpoint of excellent foam properties and convenience or portability. A squeeze container of a screen of #90 to #305 is provided in the flow path of the contents up to the discharge port.
本發明作為以泡狀製劑作為有效成分之陽離子性殺菌劑之口腔內表面吸附促進劑亦有用,該泡狀製劑含有上述成分(A)、(B)及(C):(A)烷基硫酸鈉0.05質量%以上且1質量%以下、(B)陽離子性殺菌劑0.001質量%以上且0.1質量%以下、及(C)水,且成分(B)與成分(A)之質量比((B)/(A))為0.005以上且0.7以下,且非離子界面活性劑之含量為1.2質量%以下。 The present invention is also useful as an oral surface adsorption promoter which is a cationic bactericide having a foaming preparation as an active ingredient, and the blister preparation contains the above components (A), (B) and (C): (A) alkyl sulfate 0.05% by mass or more and 1% by mass or less of sodium, (B) 0.001% by mass or more and 0.1% by mass or less of the cationic bactericide, and (C) water, and the mass ratio of the component (B) to the component (A) ((B) And (A)) is 0.005 or more and 0.7 or less, and the content of the nonionic surfactant is 1.2% by mass or less.
關於該泡狀製劑中之上述成分(A)、(B)及(C)之含量、質量比、以及其他可含有之成分,與上述泡噴出容器裝之液體口腔用組合物相同。本發明之陽離子性殺菌劑之口腔內表面吸附促進劑係藉由以該泡狀製劑作為有效成分而能夠如上述般於口腔內表面有效地提高陽離子性殺菌劑之吸附量、且有用性較高之製劑。 The content, the mass ratio, and other components which may be contained in the above-mentioned components (A), (B) and (C) in the foam preparation are the same as those in the liquid ejecting container in the above-mentioned bubble ejecting container. The oral cavity surface adsorption promoter of the cationic bactericidal agent of the present invention can effectively increase the adsorption amount of the cationic bactericide on the inner surface of the oral cavity as described above by using the blister preparation as an active ingredient, and has high usefulness. Preparation.
並且,於使用時,為了以泡狀應用於口腔內,較佳為與上述泡噴出容器裝之液體口腔用組合物同樣地將該口腔內表面吸附促進劑填充於上述泡噴出容器而成。 Further, in the case of application to the oral cavity in the form of a foam, it is preferred to fill the oral cavity surface adsorption promoter in the bubble ejection container in the same manner as the liquid oral composition in the above-described bubble ejection container.
關於上述本發明之實施態樣,進一步揭示以下之泡噴出容器裝之液體口腔用組合物、及陽離子性殺菌劑之口腔內表面吸附促進劑。 In the above-described embodiment of the present invention, the liquid oral composition contained in the following bubble ejecting container and the oral surface adsorbing agent of the cationic sterilizing agent are further disclosed.
[1]一種泡噴出容器裝之液體口腔用組合物,其含有如下成分(A)、(B)及(C):(A)烷基硫酸鈉0.05質量%以上且1質量%以下、(B)陽離子性殺菌劑0.001質量%以上且0.1質量%以下、及(C)水,且成分(B)與成分(A)之質量比((B)/(A))為0.005以上且0.7以下,且非離子界面活性劑之含量為1.2質量%以下。 [1] A liquid oral composition containing a component (A), (B), and (C): (A) sodium alkyl sulfate of 0.05% by mass or more and 1% by mass or less, (B) a cationic bactericide: 0.001% by mass or more and 0.1% by mass or less, and (C) water, and a mass ratio ((B)/(A)) of the component (B) to the component (A) is 0.005 or more and 0.7 or less. Further, the content of the nonionic surfactant is 1.2% by mass or less.
[2]如上述[1]之泡噴出容器裝之液體口腔用組合物,其中成分(A)較佳為選自月桂基硫酸鈉、及肉豆蔻基硫酸鈉中之1種或2種,更佳為月桂基硫酸鈉。 [2] The liquid oral composition according to the above [1], wherein the component (A) is preferably one or two selected from the group consisting of sodium lauryl sulfate and sodium myristyl sulfate. Good for sodium lauryl sulfate.
[3]如上述[1]或[2]之泡噴出容器裝之液體口腔用組合物,其中成分(A)之含量較佳為0.08質量%以上,更佳為0.1質量%以上,且較佳為0.7質量%以下,更佳為0.5質量%以下。 [3] The liquid oral composition according to the above [1] or [2], wherein the content of the component (A) is preferably 0.08% by mass or more, more preferably 0.1% by mass or more, and further preferably It is 0.7% by mass or less, more preferably 0.5% by mass or less.
[4]如上述[1]~[3]中任一項之泡噴出容器裝之液體口腔用組合物,其中成分(B)為選自西吡氯銨、及苄索氯銨中之1種或2種。 [4] The liquid oral composition according to any one of the above [1] to [3] wherein the component (B) is one selected from the group consisting of cetylpyridinium chloride and benzethonium chloride. Or 2 kinds.
[5]如上述[1]~[4]中任一項之泡噴出容器裝之液體口腔用組合 物,其中成分(B)之含量較佳為0.005質量%以上,更佳為0.01質量%以上,且較佳為0.07質量%以下,更佳為0.05質量%以下。 [5] The liquid oral composition of the bubble ejecting container according to any one of the above [1] to [4] The content of the component (B) is preferably 0.005% by mass or more, more preferably 0.01% by mass or more, and is preferably 0.07% by mass or less, and more preferably 0.05% by mass or less.
[6]如上述[1]~[5]中任一項之泡噴出容器裝之液體口腔用組合物,其中成分(B)與成分(A)之質量比((B)/(A))較佳為0.01以上,更佳為0.02以上,且較佳為0.5以下,更佳為0.4以下,進而較佳為0.3以下。 [6] The liquid oral composition of the bubble ejecting container according to any one of the above [1] to [5] wherein the mass ratio of the component (B) to the component (A) ((B)/(A)) It is preferably 0.01 or more, more preferably 0.02 or more, and is preferably 0.5 or less, more preferably 0.4 or less, still more preferably 0.3 or less.
[7]如上述[1]~[6]中任一項之泡噴出容器裝之液體口腔用組合物,其中成分(C)之含量較佳為55質量%以上,更佳為60質量%以上,進而較佳為65質量%以上,且較佳為99質量%以下,更佳為98.5質量%以下,進而較佳為98質量%以下。 [7] The liquid oral composition according to any one of the above [1] to [6] wherein the content of the component (C) is preferably 55 mass% or more, more preferably 60 mass% or more. Further, it is preferably 65 mass% or more, and is preferably 99 mass% or less, more preferably 98. mass% or less, still more preferably 98 mass% or less.
[8]如上述[1]~[7]中任一項之泡噴出容器裝之液體口腔用組合物,其中非離子界面活性劑之含量較佳為1質量%以下,更佳為0.8質量%以下,進而較佳為0.5質量%以下,進而更佳為0.2質量%以下,或不含有非離子界面活性劑。 [8] The liquid oral composition according to any one of the above [1] to [7] wherein the content of the nonionic surfactant is preferably 1% by mass or less, more preferably 0.8% by mass. Hereinafter, it is more preferably 0.5% by mass or less, still more preferably 0.2% by mass or less, or no nonionic surfactant.
[9]如上述[1]~[8]中任一項之泡噴出容器裝之液體口腔用組合物,其中非離子界面活性劑與成分(B)之質量比(非離子界面活性劑/(B))較佳為100以下,更佳為50以下,進而較佳為20以下,進而更佳為10以下。 [9] The liquid oral composition of the bubble ejecting container according to any one of the above [1] to [8], wherein the mass ratio of the nonionic surfactant to the component (B) (nonionic surfactant / ( B)) is preferably 100 or less, more preferably 50 or less, further preferably 20 or less, and still more preferably 10 or less.
[10]如上述[1]~[9]中任一項之泡噴出容器裝之液體口腔用組合物,其中乙醇之含量較佳為2.7質量%以下,更佳為2.5質量%以下,進而較佳為2.2質量%以下,進而更佳為2質量%以下,且較佳為超過0質量%,較佳為1質量%以上,或不含有乙醇。 [10] The liquid oral composition according to any one of the above [1] to [9], wherein the content of the ethanol is preferably 2.7% by mass or less, more preferably 2.5% by mass or less, and further It is preferably 2.2% by mass or less, more preferably 2% by mass or less, and more preferably 0% by mass or more, preferably 1% by mass or more, or no ethanol.
[11]如上述[1]~[10]中任一項之泡噴出容器裝之液體口腔用組合物,其中乙醇與非離子界面活性劑之合計含量更佳為2.7質量%以下,進而較佳為2.5質量%以下,進而更佳為2.2質量%以下,特佳為2質量%以下。 [11] The liquid oral composition according to any one of the above [1] to [10] wherein the total content of the ethanol and the nonionic surfactant is more preferably 2.7% by mass or less, and further preferably. It is 2.5% by mass or less, more preferably 2.2% by mass or less, and particularly preferably 2% by mass or less.
[12]如上述[1]~[11]中任一項之泡噴出容器裝之液體口腔用組合物,其中研磨性粉體之含量較佳為0.5質量%以下,更佳為0.4質量%以下,進而較佳為0.3質量%以下,又,進而較佳為0.2質量%以下,且較佳為超過0質量%,或不含有研磨性粉體。 [12] The liquid oral composition according to any one of the above [1] to [11], wherein the content of the abrasive powder is preferably 0.5% by mass or less, more preferably 0.4% by mass or less. Further, it is preferably 0.3% by mass or less, more preferably 0.2% by mass or less, and more preferably 0% by mass or no abrasive powder.
[13]如上述[1]~[12]中任一項之泡噴出容器裝之液體口腔用組合物,其中於20℃下為固體之糖醇之含量較佳為1質量%以下,更佳為0.5質量%以下,進而較佳為0.1質量%以下,進而更佳為0.05質量%以下,或不含有於20℃下為固體之糖醇。 [13] The liquid oral composition according to any one of the above [1] to [12] wherein the content of the solid sugar alcohol at 20 ° C is preferably 1% by mass or less, more preferably It is 0.5% by mass or less, more preferably 0.1% by mass or less, still more preferably 0.05% by mass or less, or no sugar alcohol which is solid at 20 °C.
[14]如上述[1]~[13]中任一項之泡噴出容器裝之液體口腔用組合物,其中水溶性之多價金屬鹽之金屬原子換算量與成分(A)之質量比(多價金屬/(A))較佳為0.1以下,更佳為0.01以下,進而較佳為0.005以下,進而較佳為0.001以下。 [14] The liquid oral composition of the bubble ejecting container according to any one of the above [1] to [13] wherein the ratio of the metal atom of the water-soluble polyvalent metal salt to the mass ratio of the component (A) ( The polyvalent metal/(A)) is preferably 0.1 or less, more preferably 0.01 or less, still more preferably 0.005 or less, still more preferably 0.001 or less.
[15]如上述[1]~[14]中任一項之泡噴出容器裝之液體口腔用組合物,其中檸檬酸之含量較佳為0.08質量%以下,更佳為0.05質量%以下,或本發明之泡噴出容器裝之液體口腔用組合物較佳為限於含有檸檬酸鈉之情形時含有檸檬酸。 [15] The liquid oral composition according to any one of the above [1] to [14] wherein the content of citric acid is preferably 0.08% by mass or less, more preferably 0.05% by mass or less, or The liquid oral composition of the bubble ejection container of the present invention is preferably limited to contain citric acid in the case of containing sodium citrate.
[16]如上述[1]~[15]中任一項之泡噴出容器裝之液體口腔用組合物,其中兩性界面活性劑之含量較佳為未達0.2質量%,更佳為0.15質量%以下。 [16] The liquid oral composition according to any one of the above [1] to [15] wherein the content of the amphoteric surfactant is preferably less than 0.2% by mass, more preferably 0.15% by mass. the following.
[17]如上述[1]~[16]中任一項之泡噴出容器裝之液體口腔用組合物,其中黏結劑之含量較佳為0.5質量%以下,更佳為0.3質量%以下。 [17] The liquid oral composition according to any one of the above [1] to [16] wherein the content of the binder is preferably 0.5% by mass or less, more preferably 0.3% by mass or less.
[18]如上述[1]~[17]中任一項之泡噴出容器裝之液體口腔用組合物,其於25℃下之pH值較佳為3以上,較佳為5以上,更佳為6以上,進而較佳為7以上,且較佳為11.5以下,更佳為11以下,進而較佳為10.8以下。 [18] The liquid oral composition of the bubble ejecting container according to any one of the above [1] to [17], wherein the pH at 25 ° C is preferably 3 or more, preferably 5 or more, more preferably It is 6 or more, more preferably 7 or more, and is preferably 11.5 or less, more preferably 11 or less, still more preferably 10.8 or less.
[19]如上述[1]~[18]中任一項之泡噴出容器裝之液體口腔用組合 物,其填充於泡噴出容器中。 [19] The liquid oral composition of the bubble ejecting container according to any one of the above [1] to [18] The substance is filled in a bubble ejection container.
[20]如上述[1]~[19]中任一項之泡噴出容器裝之液體口腔用組合物,其中泡噴出容器為非氣溶膠容器之擠壓式容器或泵式容器、或氣溶膠容器。 [20] The liquid oral composition according to any one of the above [1] to [19] wherein the bubble ejection container is a non-aerosol container squeeze container or pump container, or an aerosol container.
[21]一種如上述[1]~[20]中任一項之泡噴出容器裝之液體口腔用組合物之用途,其用於以泡狀應用於口腔內。 [21] The use of a liquid oral composition in a bubble ejecting container according to any one of the above [1] to [20], which is used in a bubbly form in an oral cavity.
[22]一種如上述[1]~[20]中任一項之泡噴出容器裝之液體口腔用組合物之用途,其用以使陽離子性殺菌劑吸附於口腔內表面。 [22] The use of a liquid oral composition according to any one of the above [1] to [20], which is used for adsorbing a cationic bactericide on the inner surface of the oral cavity.
[23]一種如上述[1]~[20]中任一項之泡噴出容器裝之液體口腔用組合物之用途,其用以製造陽離子性殺菌劑之口腔內表面吸附促進劑。 [23] Use of a liquid oral composition in a bubble ejecting container according to any one of the above [1] to [20], which is used for producing an oral cavity surface adsorption promoter of a cationic bactericide.
[24]一種泡噴出容器裝之液體口腔用組合物之使用方法,其係將如上述[1]~[20]中任一項之泡噴出容器裝之液體口腔用組合物泡狀地噴出並應用於口腔內。 [24] A liquid oral composition according to any one of the above [1] to [20], wherein the liquid oral composition is sprayed in a bubble form and is sprayed. Applied to the mouth.
[25]一種陽離子性殺菌劑之口腔內表面吸附促進方法,其係將如上述[1]~[20]中任一項之泡噴出容器裝之液體口腔用組合物泡狀地噴出並應用於口腔內。 [25] A method for promoting an oral cavity surface adsorption of a cationic bactericidal agent, which is obtained by bubbling and applying a liquid oral composition in a bubble ejection container according to any one of the above [1] to [20] In the mouth.
[26]一種陽離子性殺菌劑之口腔內表面吸附促進劑,其以泡狀製劑作為有效成分,該泡狀製劑含有如下成分(A)、(B)及(C):(A)烷基硫酸鈉0.05質量%以上且1質量%以下、(B)陽離子性殺菌劑0.001質量%以上且0.1質量%以下、及(C)水,且成分(B)與成分(A)之質量比((B)/(A))為0.005以上且0.7以下,且非離子界面活性劑之含量為1.2質量%以下。 [26] An oral surface adsorption promoter for a cationic bactericide, which comprises a foam preparation as an active ingredient, the blister preparation comprising the following components (A), (B) and (C): (A) alkyl sulphate 0.05% by mass or more and 1% by mass or less of sodium, (B) 0.001% by mass or more and 0.1% by mass or less of the cationic bactericide, and (C) water, and the mass ratio of the component (B) to the component (A) ((B) And (A)) is 0.005 or more and 0.7 or less, and the content of the nonionic surfactant is 1.2% by mass or less.
[27]如上述[26]之陽離子性殺菌劑之口腔內表面吸附促進劑,其中成分(A)較佳為選自月桂基硫酸鈉、及肉豆蔻基硫酸鈉中之1種或2種,更佳為月桂基硫酸鈉。 [27] The oral surface adsorption promoter of the cationic bactericide according to the above [26], wherein the component (A) is preferably one or two selected from the group consisting of sodium lauryl sulfate and sodium myristyl sulfate. More preferably sodium lauryl sulfate.
[28]如上述[26]或[27]之陽離子性殺菌劑之口腔內表面吸附促進劑,其中成分(A)之含量較佳為0.08質量%以上,更佳為0.1質量%以上,且較佳為0.7質量%以下,更佳為0.5質量%以下。 [28] The oral surface adsorption promoter of the cationic bactericide according to [26] or [27], wherein the content of the component (A) is preferably 0.08% by mass or more, more preferably 0.1% by mass or more, and more preferably The content is preferably 0.7% by mass or less, more preferably 0.5% by mass or less.
[29]如上述[26]~[28]中任一項之陽離子性殺菌劑之口腔內表面吸附促進劑,其中成分(B)為選自西吡氯銨、及苄索氯銨中之1種或2種。 [29] The oral surface adsorption promoter of the cationic bactericide according to any one of [26] to [28] wherein the component (B) is one selected from the group consisting of cetylpyridinium chloride and benzethonium chloride. Species or 2 species.
[30]如上述[26]~[29]中任一項之陽離子性殺菌劑之口腔內表面吸附促進劑,其中成分(B)之含量較佳為0.005質量%以上,更佳為0.01質量%以上,且較佳為0.07質量%以下,更佳為0.05質量%以下。 [30] The oral surface adsorption promoter of the cationic bactericide according to any one of the above [26], wherein the content of the component (B) is preferably 0.005% by mass or more, more preferably 0.01% by mass. The above is preferably 0.07% by mass or less, and more preferably 0.05% by mass or less.
[31]如上述[26]~[30]中任一項之陽離子性殺菌劑之口腔內表面吸附促進劑,其中成分(B)與成分(A)之質量比((B)/(A))較佳為0.01以上,更佳為0.02以上,且較佳為0.5以下,更佳為0.4以下,進而較佳為0.3以下。 [31] The oral surface adsorption promoter of the cationic bactericide according to any one of the above [26] to [30], wherein the mass ratio of the component (B) to the component (A) ((B)/(A) It is preferably 0.01 or more, more preferably 0.02 or more, and is preferably 0.5 or less, more preferably 0.4 or less, still more preferably 0.3 or less.
[32]如上述[26]~[31]中任一項之陽離子性殺菌劑之口腔內表面吸附促進劑,其中成分(C)之含量較佳為55質量%以上,更佳為60質量%以上,進而較佳為65質量%以上,且較佳為99質量%以下,更佳為98.5質量%以下,進而較佳為98質量%以下。 [32] The oral surface adsorption promoter of the cationic bactericide according to any one of the above [26], wherein the content of the component (C) is preferably 55 mass% or more, more preferably 60 mass%. The above is more preferably 65% by mass or more, and is preferably 99% by mass or less, more preferably 98.5% by mass or less, and still more preferably 98% by mass or less.
[33]如上述[26]~[32]中任一項之陽離子性殺菌劑之口腔內表面吸附促進劑,其中非離子界面活性劑之含量較佳為1質量%以下,更佳為0.8質量%以下,進而較佳為0.5質量%以下,進而更佳為0.2質量%以下,或不含有非離子界面活性劑。 [33] The oral surface adsorption promoter of the cationic bactericide according to any one of [26] to [32] wherein the content of the nonionic surfactant is preferably 1% by mass or less, more preferably 0.8% by mass. % or less is further preferably 0.5% by mass or less, more preferably 0.2% by mass or less, or no nonionic surfactant.
[34]如上述[26]~[33]中任一項之陽離子性殺菌劑之口腔內表面吸附促進劑,其中非離子界面活性劑與成分(B)之質量比(非離子界面活性劑/(B))較佳為100以下,更佳為50以下,進而較佳為20以下,進而更佳為10以下。 [34] The oral surface adsorption promoter of the cationic bactericide according to any one of [26] to [33], wherein the mass ratio of the nonionic surfactant to the component (B) (nonionic surfactant/ (B)) is preferably 100 or less, more preferably 50 or less, further preferably 20 or less, and still more preferably 10 or less.
[35]如上述[26]~[34]中任一項之陽離子性殺菌劑之口腔內表面 吸附促進劑,其中乙醇之含量較佳為2.7質量%以下,更佳為2.5質量%以下,進而較佳為2.2質量%以下,進而更佳為2質量%以下,且較佳為超過0質量%,較佳為1質量%以上,或不含有乙醇。 [35] The oral surface of the cationic bactericide according to any one of the above [26] to [34] The adsorption accelerator, wherein the content of the ethanol is preferably 2.7 mass% or less, more preferably 2.5% by mass or less, further preferably 2.2 mass% or less, further preferably 2 mass% or less, and more preferably more than 0 mass%. It is preferably 1% by mass or more or no ethanol.
[36]如上述[26]~[35]中任一項之陽離子性殺菌劑之口腔內表面吸附促進劑,其中乙醇與非離子界面活性劑之合計含量更佳為2.7質量%以下,進而較佳為2.5質量%以下,進而更佳為2.2質量%以下,特佳為2質量%以下。 [36] The oral surface adsorption promoter of the cationic bactericide according to any one of [26] to [35], wherein the total content of the ethanol and the nonionic surfactant is more preferably 2.7% by mass or less, and further It is preferably 2.5% by mass or less, more preferably 2.2% by mass or less, and particularly preferably 2% by mass or less.
[37]如上述[26]~[36]中任一項之陽離子性殺菌劑之口腔內表面吸附促進劑,其中研磨性粉體之含量較佳為0.5質量%以下,更佳為0.4質量%以下,進而較佳為0.3質量%以下,又,進而較佳為0.2質量%以下,且較佳為超過0質量%,或不含有研磨性粉體。 [37] The oral surface adsorption promoter of the cationic bactericide according to any one of the above [26], wherein the content of the abrasive powder is preferably 0.5% by mass or less, more preferably 0.4% by mass. In the following, it is preferably 0.3% by mass or less, more preferably 0.2% by mass or less, and more preferably 0% by mass or no abrasive powder.
[38]如上述[26]~[37]中任一項之陽離子性殺菌劑之口腔內表面吸附促進劑,其中於20℃下為固體之糖醇之含量較佳為1質量%以下,更佳為0.5質量%以下,進而較佳為0.1質量%以下,進而更佳為0.05質量%以下,或不含有於20℃下為固體之糖醇。 [38] The oral surface adsorption promoter of the cationic bactericide according to any one of the above [26], wherein the content of the solid sugar alcohol at 20 ° C is preferably 1% by mass or less. It is preferably 0.5% by mass or less, more preferably 0.1% by mass or less, still more preferably 0.05% by mass or less, or no sugar alcohol which is solid at 20 °C.
[39]如上述[26]~[38]中任一項之陽離子性殺菌劑之口腔內表面吸附促進劑,其中水溶性之多價金屬鹽之金屬原子換算量與成分(A)之質量比(多價金屬/(A))較佳為0.1以下,更佳為0.01以下,進而較佳為0.005以下,進而較佳為0.001以下。 [39] The oral surface adsorption promoter of the cationic bactericide according to any one of the above [26] to [38], wherein the ratio of the metal atom of the water-soluble polyvalent metal salt to the mass ratio of the component (A) The polyvalent metal/(A) is preferably 0.1 or less, more preferably 0.01 or less, still more preferably 0.005 or less, still more preferably 0.001 or less.
[40]如上述[26]~[39]中任一項之陽離子性殺菌劑之口腔內表面吸附促進劑,其中兩性界面活性劑之含量較佳為未達0.2質量%,更佳為0.15質量%以下。 [40] The oral surface adsorption promoter of the cationic bactericide according to any one of [26] to [39] wherein the amphoteric surfactant is preferably less than 0.2% by mass, more preferably 0.15 by mass. %the following.
[41]如上述[26]~[40]中任一項之陽離子性殺菌劑之口腔內表面吸附促進劑,其中黏結劑之含量較佳為0.5質量%以下,更佳為0.3質量%以下。 [41] The oral surface adsorption promoter of the cationic bactericide according to any one of the above [26], wherein the content of the binder is preferably 0.5% by mass or less, more preferably 0.3% by mass or less.
[42]如上述[26]~[41]中任一項之陽離子性殺菌劑之口腔內表面 吸附促進劑,其於25℃下之pH值較佳為3以上,較佳為5以上,更佳為6以上,進而較佳為7以上,且較佳為11.5以下,更佳為11以下,進而較佳為10.8以下。 [42] The oral surface of the cationic bactericide according to any one of the above [26] to [41] The adsorption accelerator preferably has a pH of 3 or more, preferably 5 or more, more preferably 6 or more, further preferably 7 or more, and more preferably 11.5 or less, more preferably 11 or less, at 25 ° C. More preferably, it is 10.8 or less.
[43]如上述[26]~[42]中任一項之陽離子性殺菌劑之口腔內表面吸附促進劑,其填充於泡噴出容器中。 [43] The oral surface adsorption promoter of the cationic bactericide according to any one of [26] to [42] above, which is filled in a bubble ejection container.
[44]如上述[43]之陽離子性殺菌劑之口腔內表面吸附促進劑,其中泡噴出容器為非氣溶膠容器之擠壓式容器或泵式容器、或氣溶膠容器。 [44] The oral surface adsorption promoter of the cationic bactericide according to [43] above, wherein the bubble ejection container is a non-aerosol container squeeze container or a pump container, or an aerosol container.
[45]一種如上述[26]~[44]中任一項之陽離子性殺菌劑之口腔內表面吸附促進劑之用途,其用於以泡狀應用於口腔內。 [45] Use of the oral surface adsorption promoter of the cationic bactericide according to any one of [26] to [44], which is used for application to the oral cavity in a foam form.
[46]一種陽離子性殺菌劑之口腔內表面吸附促進劑之使用方法,其係將如上述[26]~[44]中任一項之陽離子性殺菌劑之口腔內表面吸附促進劑泡狀地噴出並應用於口腔內。 [46] A method of using an oral cavity surface adsorption promoter of a cationic bactericide according to any one of the above [26] to [44], wherein the oral surface adsorption promoter is blister-like Spray and apply to the mouth.
[47]一種陽離子性殺菌劑之口腔內表面吸附促進方法,其係將如上述[26]~[44]中任一項之陽離子性殺菌劑之口腔內表面吸附促進劑泡狀地噴出並應用於口腔內。 [47] A method for promoting an oral surface adsorption of a cationic bactericide, which is obtained by bubbling and applying an oral surface adsorption promoter of a cationic bactericide according to any one of the above [26] to [44] In the mouth.
[實施例] [Examples]
以下,基於實施例對本發明具體地進行說明。再者,只要於表中無特別表示,則各成分之含量表示質量%。 Hereinafter, the present invention will be specifically described based on examples. In addition, as long as it is not specifically shown in the table, the content of each component represents mass %.
[實施例1~8、比較例1~8] [Examples 1 to 8 and Comparative Examples 1 to 8]
按照表1~2所示之配方,製備液體口腔用組合物。 Liquid oral compositions were prepared according to the formulations shown in Tables 1-2.
再者,實施例1~8係將所獲得之各液體口腔用組合物填充於泵發泡容器(大和製罐(股);F5泵發泡;篩網:2片;篩網尺寸:#255/#255)而自噴出口噴出內容物,以泡狀試樣之形式採取1.0g。比較例1~8係將所獲得之各液體口腔用組合物1.0g不填充於容器中而以液狀試樣之形式直接使用。 Further, in Examples 1 to 8, the obtained liquid oral compositions were filled in a pump foaming container (large and canned); F5 pump was foamed; sieve: 2; sieve size: #255 /#255) The contents were ejected from the discharge port, and 1.0 g was taken as a blister sample. In Comparative Examples 1 to 8, 1.0 g of each liquid oral composition obtained was used in the form of a liquid sample without being filled in a container.
繼而,使用所獲得之各試樣,採用聚矽氧片作為口腔內黏膜之模型,並按照以下方法,對陽離子性殺菌劑於該聚矽氧片上之吸附量進行測定。再者,進而表1中之陽離子性殺菌劑於聚矽氧片上之吸附量係以將與各實施例對應之比較例之陽離子性殺菌劑之吸附量設為100時的實施例之陽離子性殺菌劑之吸附量為指數而表示以顯示出泡狀之組合物相對於液狀之組合物之優勢。 Then, using each of the obtained samples, a polyfluorene oxide sheet was used as a model of the oral cavity mucosa, and the amount of adsorption of the cationic bactericide on the polyfluorene oxide sheet was measured in accordance with the following method. Further, the amount of adsorption of the cationic bactericidal agent in Table 1 on the polyfluorene oxide sheet is the cationic sterilization of the example in which the adsorption amount of the cationic bactericide of the comparative example corresponding to each example is set to 100. The amount of adsorption of the agent is expressed as an index to show the advantage of the composition of the foamed composition relative to the liquid composition.
又,採用HAP(羥磷灰石)粉作為齒面之模型,按照以下方法,對陽離子性殺菌劑於該HAP粉上之吸附量進行測定。再者,表2中之陽離子性殺菌劑於HAP粉上之吸附量係以將與各實施例對應之比較例之陽離子性殺菌劑之吸附量設為100時的實施例之陽離子性殺菌劑之吸附量為指數而表示。將結果示於表1~2。 Further, HAP (hydroxyapatite) powder was used as a model of the tooth surface, and the amount of adsorption of the cationic bactericide on the HAP powder was measured by the following method. In addition, the amount of the cationic bactericide in Table 2 adsorbed on the HAP powder is a cationic bactericide of the example in which the amount of the cationic bactericide of the comparative example corresponding to each example is set to 100. The amount of adsorption is expressed as an index. The results are shown in Tables 1 and 2.
《陽離子性殺菌劑於聚矽氧片上之吸附量測定》 Determination of Adsorption Capacity of Cationic Fungicides on Polyfluorene Oxide Tablets
將圓柱管(橫截面積7.07×10-4m2)以其中一開口端面密接於聚矽氧片之表面之方式載置於聚矽氧片(500mm×500mm,厚度0.1mm,TIGERS POLYMER公司製造)上。繼而,以試樣與聚矽氧片之接觸面積變得與圓柱管之內側橫截面積相同之方式,將各試樣1.0g自圓柱管之另一端開口投入至圓柱管內,使其應用於被圓柱管之周面所包圍之圓柱管內側之聚矽氧片之表面上,於使試樣與聚矽氧片接觸之狀態下放置2分鐘。 The cylindrical tube (cross-sectional area: 7.07×10 -4 m 2 ) was placed on the surface of the polyfluorene oxide sheet with one of the open end faces adhered to the surface of the polyfluorene oxide sheet (500 mm × 500 mm, thickness 0.1 mm, manufactured by TIGERS POLYMER) )on. Then, 1.0 g of each sample was thrown into the cylindrical tube from the other end of the cylindrical tube so that the contact area between the sample and the polyfluorene oxide sheet became the same as the inner cross-sectional area of the cylindrical tube, and the application was carried out. On the surface of the polyfluorene oxide sheet inside the cylindrical tube surrounded by the circumferential surface of the cylindrical tube, the sample was placed in contact with the polyfluorene oxide sheet for 2 minutes.
將所獲得之各聚矽氧片浸漬於50mL燒杯內之離子交換水中30秒,其後,自燒杯取出,應用萃取液1.5mL(下述所示之流動相)30秒,回收陽離子性殺菌劑,藉由高效液相層析法(HPLC),按照下述測定條件進行陽離子性殺菌劑之定量(μg/m2)。 Each of the obtained polyfluorene oxide sheets was immersed in ion-exchanged water in a 50 mL beaker for 30 seconds, and then taken out from the beaker, and 1.5 mL of an extract (mobile phase shown below) was applied for 30 seconds to recover a cationic bactericide. The amount of the cationic bactericide (μg/m 2 ) was measured by high performance liquid chromatography (HPLC) under the following measurement conditions.
<HPLC測定條件> <HPLC measurement conditions>
裝置:日立高效液相層析圖La chromElite Device: Hitachi High Performance Liquid Chromatography La chromElite
檢測器:紫外吸光光度計(測定波長:260nm) Detector: UV spectrophotometer (measuring wavelength: 260 nm)
管柱:CAPCELL PAK SCX UG80(4.6×100mm,5μm)(資生堂(股)) Pipe column: CAPCELL PAK SCX UG80 (4.6×100mm, 5μm) (Shiseido (share))
管柱溫度:40℃ Column temperature: 40 ° C
流動相:甲醇/水之混液(3:1)+0.05mol/L過氯酸鈉-水合物 Mobile phase: methanol/water mixture (3:1) +0.05 mol/L sodium perchlorate-hydrate
流量:1.2mL/min Flow rate: 1.2mL/min
《陽離子性殺菌劑於HAP粉上之吸附量測定》 "Determination of the adsorption amount of cationic bactericide on HAP powder"
將HAP粉(HAP200(太平化學產業),比表面積9.97m2/g)0.1g投入至50mL之管體,其後,進而投入各試樣1.0g。繼而,使用離心分離機/旋渦混合器(SHIBATA TTM-1)將各管體之內容物攪拌2分鐘,其後,於25℃下以轉數3000rpm進行10分鐘離心分離。將離心分離後之上清液廢棄,其後,將離子交換水1mL投入至管體再次攪拌30秒鐘,再次進行同樣之離心分離並將上清液廢棄,重複進行2次該攪拌及離心分離之處理。 0.1 g of HAP powder (HAP200 (Taihei Chemical Industry), specific surface area: 9.97 m 2 / g) was placed in a 50 mL tube, and then 1.0 g of each sample was further charged. Then, the contents of the respective tubes were stirred for 2 minutes using a centrifugal separator/vortex mixer (SHIBATA TTM-1), and then centrifuged at 25 ° C for 10 minutes at 3000 rpm. After the centrifugation, the supernatant was discarded, and then 1 mL of ion-exchanged water was poured into the tube and stirred for another 30 seconds, and the same centrifugal separation was performed again, and the supernatant was discarded, and the stirring and centrifugation were repeated twice. Processing.
對將上清液廢棄之後之管體之內容物應用萃取液1.5mL(下述所示之流動相)30秒鐘,將陽離子性殺菌劑回收,藉由高效液相層析法(HPLC)並按照與上述同樣之測定條件進行陽離子性殺菌劑之定量(ng/m2)。 Apply 1.5 mL of the extract (mobile phase shown below) to the contents of the tube after discarding the supernatant for 30 seconds to recover the cationic bactericide by high performance liquid chromatography (HPLC). The amount of the cationic bactericide (ng/m 2 ) was measured in accordance with the same measurement conditions as above.
[實施例9~13、比較例10~11] [Examples 9 to 13 and Comparative Examples 10 to 11]
按照表3所示之配方製備液體口腔用組合物,其後,與實施例1同樣地將所獲得之各液體口腔用組合物填充於泵發泡容器中使內容物 自噴出口噴出,以泡狀試樣之形式採取1.0g。 The liquid oral composition was prepared according to the formulation shown in Table 3, and then the obtained liquid oral composition was filled in a pump foaming container in the same manner as in Example 1 to make the contents It was sprayed from the discharge port and taken in the form of a blister sample of 1.0 g.
繼而,使用所獲得之各試樣,按照上述方法對陽離子性殺菌劑於聚矽氧片上之吸附量、及陽離子性殺菌劑於HAP(羥磷灰石)粉上之吸附量進行測定。 Then, using each of the obtained samples, the amount of adsorption of the cationic bactericide on the polyfluorene oxide sheet and the amount of adsorption of the cationic bactericide on the HAP (hydroxyapatite) powder were measured in accordance with the above method.
將結果示於表3。 The results are shown in Table 3.
《泡性能之評價》 "Evaluation of bubble performance"
使用實施例1、4、13所獲得之試樣,按照以下方法對泡性能進行評價。 Using the samples obtained in Examples 1, 4, and 13, the foam properties were evaluated in the following manner.
將5片濾紙(ADVANTEC製造,No.1,70mm)重疊,使將各試樣利用泡噴出容器製作而成之泡1.0g載置於重疊5片之濾紙上。使各試樣之泡載置於濾紙之後靜置10秒鐘,其後,藉由Kimwipe(大王製紙(股),Soft Wiper S150 Box)對泡進行擦拭。對擦拭過泡之後之濾紙中所包含之試樣之重量(g)進行測定並設為排液量(g)。以排液率(%)= (排液量(g))/(1.0(g))×100之方式算出排液率。排液率越高,意指泡沫持久性越低。 Five sheets of filter paper (manufactured by ADVANTEC, No. 1, 70 mm) were placed one on top of the other, and 1.0 g of each of the samples prepared by using a bubble discharge container was placed on five sheets of filter paper. The bubble of each sample was placed on the filter paper and allowed to stand for 10 seconds, after which the bubbles were wiped by Kimwipe (Soft Wiper S150 Box). The weight (g) of the sample contained in the filter paper after the wiping was wiped was measured and set as the discharge amount (g). With drainage rate (%) = The liquid discharge rate was calculated by the method of (liquid discharge amount (g)) / (1.0 (g)) × 100. The higher the drainage rate, the lower the durability of the foam.
將結果示於表4。如表4所示,可確認:成分(B)與成分(A)之質量比((B)/(A))越大,排液率越高。 The results are shown in Table 4. As shown in Table 4, it was confirmed that the larger the mass ratio ((B)/(A)) of the component (B) to the component (A), the higher the liquid discharge rate.
[實施例14、比較例14] [Example 14 and Comparative Example 14]
按照表5所示之配方製備液體口腔用組合物,其後,與實施例1同樣地將所獲得之各液體口腔用組合物填充於泵發泡容器中使內容物自噴出口噴出,以泡狀試樣之形式採取1.0g。 The liquid oral composition was prepared according to the formulation shown in Table 5, and then the obtained liquid oral composition was filled in a pump foam container in the same manner as in Example 1, and the contents were ejected from the discharge port to form a bubble. The sample was taken in the form of 1.0 g.
繼而,使用所獲得之各試樣,按照上述方法對陽離子性殺菌劑於聚矽氧片上之吸附量進行測定。 Then, using each of the obtained samples, the amount of adsorption of the cationic bactericide on the polyfluorene oxide sheet was measured in accordance with the above method.
將結果示於表5。 The results are shown in Table 5.
《味道評價》 Taste Evaluation
使用實施例5~7所獲得之液體口腔用組合物進行味道評價。具體而言,將各液體口腔用組合物數mL含於口腔內,以實施例6之味道評價(味道與刺激之有無)為基準,進行實施例5及7之味道評價。再者,評價以1人進行。 The taste evaluation was carried out using the liquid oral compositions obtained in Examples 5 to 7. Specifically, the number of mL of each of the liquid oral compositions was contained in the oral cavity, and the taste evaluation of Examples 5 and 7 was carried out based on the taste evaluation (the presence or absence of taste and irritation) of Example 6. Furthermore, the evaluation was performed by one person.
將結果示於表6。實施例5為與實施例6同等之味道,但實施例7較實施例6明顯地感覺到異味,亦強烈地感覺到刺激。 The results are shown in Table 6. Example 5 is the same taste as Example 6, but Example 7 clearly perceived odor compared to Example 6, and also strongly felt the irritation.
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