TW201720422A - Liquid oral cavity composition contained in foam dispensing container for effectively promoting the adsorption of a cationic bactericide on the surface of the oral cavity - Google Patents

Abstract

The present invention relates to a liquid oral cavity composition that is applied as foam into the oral cavity in use so as to effectively promote the adsorption of a cationic bactericide on the surface of the oral cavity. That is, the present invention provides a liquid oral composition contained in a foam dispensing container, which comprises the components of: (A) 0.05 mass% to 1 mass% of sodium alkylsulfate, (B) 0.001 mass% to 0.1 mass% of cationic bactericide, and (C) water, wherein the ratio by mass of component (B) to component (A) [(B)/(A)] is 0.005 to 0.7, and the content of a nonionic surfactant is 1.2 mass% or less.

Description

Liquid oral composition for foaming out of a container

The present invention relates to a liquid oral composition for a bubble spray container.

Conventionally, there has been known an oral composition which is filled in a container capable of ejecting a content in a bubble form in a bubble form from a discharge port, and which exhibits desired performance. For example, Patent Literatures 1 to 2 disclose an oral composition containing a surfactant and a specific binder or a cationic polymer, which are all filled with a non-aerosol type gas-free atmospheric pressure container and capable of being filled. A composition which improves the shape retention or stability of the foam and which gives a good feeling of use and the like. Further, in Patent Document 3, by using two or more kinds of anionic surfactants together with a specific nonionic surfactant such as fatty acid dialkamine, foam retention is achieved in the form of a foamy oral composition. Stabilization.

Further, Patent Document 4 discloses a foamed oral composition containing an anionic surfactant, a nonionic surfactant or an amphoteric surfactant, and a thickener or a binder, which maintains good bubble persistence and the like. And increasing the dispersibility of the composition in the oral cavity.

(Patent Document 1) Japanese Patent Laid-Open No. Hei 9-295923

(Patent Document 2) Japanese Patent Laid-Open Publication No. 2001-172144

(Patent Document 3) Japanese Patent Laid-Open No. Hei 10-139643

(Patent Document 4) Japanese Patent Laid-Open No. Hei 8-333226

The present invention relates to a liquid oral composition containing a bubble spray container, which comprises The following components (A), (B), and (C): (A) a sodium alkyl sulfate of 0.05% by mass or more and 1% by mass or less, and (B) a cationic bactericide: 0.001% by mass or more and 0.1% by mass or less, and ( C) Water, and the mass ratio of the component (B) to the component (A) ((B)/(A)) is 0.005 or more and 0.7 or less, and the content of the nonionic surfactant is 1.2 mass% or less.

Further, the present invention relates to an oral surface adsorption promoter for a cationic bactericide which comprises a foam preparation as an active ingredient, and the blister preparation contains the following components (A), (B) and (C): (A) 0.05% by mass or more and 1% by mass or less of the sodium alkyl sulfate, (B) 0.001% by mass or more and 0.1% by mass or less of the cationic bactericide, and (C) water, and the mass ratio of the component (B) to the component (A) ((B)/(A))) is 0.005 or more and 0.7 or less, and the content of the nonionic surfactant is 1.2 mass% or less.

In order to effectively prevent or prevent gingivitis or periodontitis or bad breath in the oral cavity, it is effective to adsorb a cationic bactericide to the oral mucosa and suppress the formation of a biofilm caused by bacteria in the oral cavity.

However, in the composition described in any of the above documents, the type or content of an anionic surfactant, a nonionic surfactant, or the like is not sufficiently studied, and even if the compositions are applied in a bubble form, It is also difficult to ensure a high adsorption amount of the cationic bactericide in the oral cavity.

Accordingly, the present invention relates to a liquid oral composition capable of effectively promoting the adsorption of a cationic bactericide on the inner surface of the oral cavity by application to the oral cavity in a foam form during use.

Therefore, the inventors conducted various studies and found that a specific amount of sodium alkyl sulfate and a cationic bactericide as an anionic surfactant together with water were used. And a specific mass ratio, and limiting the content of the nonionic surfactant, a bubble ejecting container capable of effectively promoting the adsorption of the cationic bactericide on the inner surface of the oral cavity while being applied to the oral cavity in a bubble form is obtained. A liquid oral composition.

According to the present invention, it can be applied to the oral cavity in a foam form at the time of use, and the amount of adsorption of the cationic bactericidal agent on the inner surface of the oral cavity can be effectively increased. Moreover, in the present invention, an oral surface adsorption promoter which is a cationic bactericide which is an active ingredient in a foam preparation is also extremely useful.

Hereinafter, the present invention will be described in detail.

The liquid oral composition contained in the bubble ejecting container of the present invention contains 0.05% by mass or more and 1% by mass or less of sodium alkyl sulfate as the component (A). By containing the component (A) in an amount, it is possible to form a good bubble upon ejection from the container, and it is possible to effectively suppress the decrease in the amount of adsorption of the cationic bactericide on the inner surface of the oral cavity of the component (B) described later. .

The component (A) is, for example, a sodium alkyl sulfate having a saturated or unsaturated alkyl group having 8 to 18 carbon atoms, preferably an alkyl group having a saturated or unsaturated alkyl group having 10 to 16 carbon atoms. Sodium sulfate, preferably sodium alkyl sulfate having a saturated alkyl group having 10 to 16 carbon atoms, more preferably one or two selected from the group consisting of sodium lauryl sulfate and sodium myristyl sulfate, and further preferably It is sodium lauryl sulfate.

The content of the component (A) is 0.05% by mass or more, preferably 0.08% by mass or more, based on the liquid oral composition contained in the bubble ejecting container of the present invention, from the viewpoint of forming a good foam when the container is ejected. More preferably, it is 0.1% by mass or more. Further, from the viewpoint of effectively increasing the amount of adsorption of the cationic bactericide of the component (B) on the inner surface of the oral cavity, the content of the component (A) is 1 in the liquid oral composition of the blister container of the present invention. The mass% or less is preferably 0.7% by mass or less, more preferably 0.5% by mass or less. And, component (A) The content in the liquid oral composition contained in the bubble ejection container of the present invention is 0.05% by mass or more and 1% by mass or less, preferably 0.08% to 0.7% by mass, more preferably 0.1% to 0.5% by mass.

The liquid oral composition contained in the bubble ejecting container of the present invention contains the cationic bactericide in an amount of 0.001% by mass or more and 0.1% by mass or less as the component (B). According to the liquid oral composition of the bubble ejection container of the present invention, the component (B) can be efficiently adsorbed to the inner surface of the oral cavity, and the gingivitis or periodontitis or the bad breath can be prevented or Prevention brings a higher effect.

The component (B) is, for example, a quaternary ammonium compound. Specifically, it is preferably one or two selected from the group consisting of cetylpyridinium chloride and benzethonium chloride.

The content of the component (B) is 0.001% by mass or more, preferably 0.005% by mass or more, more preferably 0.005% by mass or more, from the viewpoint of ensuring the amount of adsorption on the inner surface of the oral cavity in the liquid oral composition of the foam ejecting container of the present invention. Preferably, it is 0.01% by mass or more. In addition, the content of the component (B) is 0.1% by mass or less, preferably 0.07% by mass or less, more preferably 0.07% by mass or less, from the viewpoint of maintaining a good feeling of use. It is 0.05% by mass or less. Further, the content of the component (B) is 0.001% by mass or more and 0.1% by mass or less, preferably 0.005 to 0.07% by mass, more preferably 0.01 to 0.05% by mass in the liquid oral composition contained in the bubble ejection container of the present invention. %.

The mass ratio ((B)/(A)) of the component (B) to the component (A) is 0.005 or more, preferably 0.01 or more, from the viewpoint of increasing the amount of adsorption of the component (B) on the inner surface of the oral cavity. Good is 0.02 or above. Further, in terms of forming a good bubble from the ejection of the container, improving the sustainability of the bubble, and improving the amount of adsorption of the component (B) on the inner surface of the oral cavity by the bubble, the component (B) and the component (A) The mass ratio ((B)/(A))) is 0.7 or less, preferably 0.5 or less, more preferably 0.4 or less, still more preferably 0.3 or less. Further, the mass ratio ((B)/(A)) of the component (B) to the component (A) is 0.005 to 0.7, preferably 0.01 to 0.5, more preferably 0.02 to 0.4, still more preferably 0.02 to 0.3.

The liquid oral composition contained in the bubble ejection container of the present invention contains water as the component (C). The water of the component (C) in the present invention means not only the purified water or ion-exchanged water or the like contained in the liquid oral composition contained in the bubble ejecting container, but also the moisture contained in the formulated components. All of the moisture contained in the liquid oral composition. By containing the water of the component (C), good shape retention property can be maintained, and each component can be well dispersed or dissolved to diffuse well in the oral cavity, and the component (B) can be favorably embedded to form a bubble.

The content of the component (C) is preferably 55% by mass in the liquid oral composition of the bubble ejection container of the present invention, from the viewpoint of allowing the components to be well dispersed or dissolved, and the feeling of good use. The above is more preferably 60% by mass or more, and still more preferably 65% by mass or more. Further, from the viewpoint of forming a good foam and maintaining the discharge property from the container, and improving the adsorption property of the component (B) on the inner surface of the oral cavity, the content of the component (C) is contained in the bubble ejection container of the present invention. The liquid oral composition is preferably 99% by mass or less, more preferably 98.5% by mass or less, still more preferably 98% by mass or less. Further, the content of the component (C) is preferably 55 mass% or more and 99 mass% or less, more preferably 60 to 98. mass%, more preferably 60 to 98. mass%, more preferably in the liquid oral composition of the bubble spray container of the present invention. 65 to 98% by mass.

The mass ratio ((A)/(C)) of the component (A) to the component (C) is preferably 0.05 × 10 ^-2 or more, more preferably 0.07, from the viewpoint of forming a good bubble from the ejection of the container. ×10 ^-2 or more, further preferably 0.08 × 10 ^-2 or more, and still more preferably 0.1 × 10 ^-2 or more. Further, the mass ratio ((A)/(C)) of the component (A) to the component (C) is preferably 1.5 × 10 from the viewpoint of dispersing or dissolving each component well and diffusing well in the oral cavity. ^{It is -2} or less, more preferably 1.2 × 10 ^-2 or less, further preferably 1 × 10 ^-2 or less, further preferably 0.8 × 10 ^-2 or less, and still more preferably 0.65 × 10 ^-2 or less. Further, the mass ratio ((A)/(C)) of the component (A) to the component (C) is preferably 0.05 × 10 ^-2 to 1.5 × 10 ^-2 , more preferably 0.07 × 10 ^-2 to 1.2 × 10 ^-2, and further preferably ^{0.08 × 10 -2 ~ 1 × 10} -2, and further more preferably ^{0.1 × 10 -2 ~ 0.8 × 10} -2, and further more preferably ^{0.1 × 10 -2 ~ 0.65 × 10} -2 .

The mass ratio ((B)/(C)) of the component (B) to the component (C) is preferably 0.05 × 10 ^-3 or more, more preferably 0.07, from the viewpoint of forming a good bubble from the ejection of the container. ×10 ^-3 or more, further preferably 0.08 × 10 ^-3 or more, and still more preferably 0.1 × 10 ^-3 or more. Further, the mass ratio ((B)/(C)) of the component (B) to the component (C) is preferably 1 × 10 from the viewpoint that the components are well dispersed or dissolved and diffused well in the oral cavity. ^{It is -3} or less, more preferably 0.8 × 10 ^-3 or less, further preferably 0.7 × 10 ^-3 or less, and still more preferably 0.6 × 10 ^-3 or less. Further, the mass ratio of the component (B) to the component (C) ((B)/(C)) is preferably 0.05 × 10 ^-3 to 1 × 10 ^-3 , more preferably 0.07 × 10 ^-3 to 0.8 × 10 ^-3, further preferably ^{0.08 × 10 -3 ~ 0.7 × 10} -3, and further more preferably ^{0.1 × 10 -3 ~ 0.6 × 10} -3.

In the liquid oral composition of the bubble jet container of the present invention, the content of the nonionic surfactant is 1.2% by mass or less. By restricting the content of the nonionic surfactant in this manner, it is possible to ensure the formation of a good bubble at the time of ejection from the container, and to effectively promote the adsorption of the component (B) on the inner surface of the oral cavity. Examples of the nonionic surfactant include polyoxyethylene hydrogenated castor oil, sucrose fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester such as glycerin monostearate or glycerol monooleate; Alkyl glucoside; polyoxyethylene alkyl ether such as polyoxyethylene monoalkyl (or alkenyl) ether, polyoxyethylene polyoxypropylene copolymer; polyoxyethylene phenyl ether such as polyoxyethylene nonylphenyl ether; amine oxide Surfactant; mono-(or di-)ethanolamine, coconut oil fatty acid diethanolamine, and other fatty acid alkanolamines; polyglyceryl-10 stearate, polyglycerol-10 laurate, polyglycerol- One or two or more kinds of polyglycerol fatty acid esters such as oleic acid ester; and polyglycols such as polyethylene polypropylene glycol. Among them, as the usable nonionic surfactant, one or two selected from the group consisting of polyoxyethylene hydrogenated castor oil, sucrose fatty acid ester, sorbitan fatty acid ester, and polyglycerin fatty acid ester are preferable. the above.

The content of the nonionic surfactant is 1.2% by mass in the liquid oral composition of the bubble ejection container of the present invention from the viewpoint of maintaining good ejection properties and improving the adsorption of the component (B) on the inner surface of the oral cavity. Hereinafter, it is preferably 1% by mass or less, more preferably 0.8% by mass. % or less, further preferably 0.5% by mass or less, more preferably 0.2% by mass or less, or the liquid oral composition contained in the bubble jet container of the present invention may not contain a nonionic surfactant.

The mass ratio of the nonionic surfactant to the component (B) (nonionic surfactant/(B)) is preferably 100 or less from the viewpoint of effectively suppressing the decrease in the amount of adsorption of the component (B) on the inner surface of the oral cavity. More preferably, it is 50 or less, further preferably 20 or less, and still more preferably 10 or less.

With respect to the liquid oral composition of the bubble ejecting container of the present invention, in the liquid oral composition of the bubble ejecting container of the present invention, the content of ethanol is preferably 2.7 by mass in terms of ensuring the retention of the foam. % or less is more preferably 2.5% by mass or less, further preferably 2.2% by mass or less, further preferably 2% by mass or less, and more preferably 0% by mass or more, and preferably 1% by mass or more. Further, the content of the ethanol is preferably 2.7 mass% or less, more preferably 0 to 2.7% by mass, still more preferably 0 to 2.5% by mass, and further preferably 0 to 2.5% by mass, and more preferably the liquid oral composition contained in the bubble ejecting container of the present invention. Preferably, it is 0 to 2.2% by mass, particularly preferably 0 to 2% by mass, and more preferably more than 0% by mass and 2.7% by mass or less, more preferably 1 to 2.5% by mass, still more preferably 1 to 2.2% by mass, Particularly preferred is 1 to 2% by mass.

Further, from the viewpoint of ensuring the solubility or dispersibility of each component and the foam quality which is excellent when ejected from the container, the total content of the ethanol and the nonionic surfactant is in the liquid oral cavity of the bubble ejecting container of the present invention. The composition is preferably 3% by mass or less, more preferably 2.7% by mass or less, still more preferably 2.5% by mass or less, still more preferably 2.2% by mass or less, and particularly preferably 2% by mass or less.

The liquid oral composition contained in the bubble ejecting container of the present invention is preferably in the liquid oral composition contained in the bubble ejecting container of the present invention from the viewpoint of ensuring good discharge property from the container. The content of the powder is 0.5% by mass or less, more preferably 0.4% by mass or less, further preferably 0.3% by mass or less, further preferably 0.2% by mass or less, and more preferably 0% by mass or the present invention. The liquid oral composition contained in the bubble ejection container preferably does not contain an abrasive powder. Moreover, the content of the abrasive powder is in the present invention. The liquid oral composition contained in the bubble ejecting container is preferably 0.5% by mass or less, more preferably 0 to 0.4% by mass, still more preferably 0 to 0.3% by mass, and still more preferably 0 to 0.2% by mass. %, or the liquid oral composition contained in the bubble ejecting container of the present invention preferably does not contain an abrasive powder.

Examples of the abrasive powder include light calcium carbonate, heavy calcium carbonate, zeolite, abrasive cerium oxide having an oil absorption of 50 to 150 mL/100 g, dicalcium phosphate, tricalcium phosphate, and insoluble metaphosphoric acid. One or more of sodium, aluminum hydroxide, magnesium phosphate, calcium pyrophosphate, and magnesium carbonate.

In addition, the amount of oil absorption is the amount of oil that can be carried by cerium oxide, and the measurement method is based on the amount of cooked linseed oil absorbed by a method based on JIS K5101-13-2 (2004). specific.

From the viewpoint of preventing the pressing from being unnecessarily high when the container is ejected, and effectively preventing the clogging of the pores of the porous member due to the adhesion of the composition due to the porous member of the bubble ejecting container, the excellent ejection property is ensured. In view of the above, the liquid oral composition of the bubble ejecting container of the present invention preferably limits the content of the sugar alcohol which is solid at 20 °C. Examples of the sugar alcohol which is solid at 20 ° C include sorbitol, xylitol, erythritol, mannitol, isomalt, and the like.

The content of the solid sugar alcohol at 20 ° C is preferably 1% by mass or less, more preferably 0.5% by mass or less, still more preferably 0.1% by mass, based on the liquid oral composition contained in the bubble spray container of the present invention. In the following, it is more preferably 0.05% by mass or less, or the liquid oral composition contained in the bubble ejecting container of the present invention preferably does not contain a sugar alcohol which is solid at 20 °C.

The liquid oral composition of the bubble spray container of the present invention is preferably water-soluble from the viewpoint of forming a good bubble at the time of ejection from the container, the viewpoint of ensuring the retention of the bubble, and the viewpoint of maintaining a good fragrance. The content of the polyvalent metal salt is limited. Examples of the water-soluble polyvalent metal salt include calcium oxide, calcium hydroxide, calcium chloride, and calcium sulfate. Calcium phosphate, calcium stearate, calcium pantothenate, etc.; aluminum lactate, chlorohydroxy aluminum, allantoin hydroxy aluminum, allantoin chlorohydroxy aluminum, allantoin dihydroxy aluminum, p-phenol sulfonate, chlorination Aluminum salts such as aluminum, alum (potassium sulfate aluminum dodecahydrate), sodium alum (sodium sulfate aluminum dodecahydrate) aluminum nitrate; zinc phenolsulfonate, zinc chloride, zinc gluconate, zinc acetate, zinc sulfate Such as zinc salt; magnesium gluconate, magnesium sulfate, magnesium chloride and other magnesium salts. Further, the water-soluble polyvalent metal salt means that a salt of a polyvalent metal ion is released in water, and specifically, a water-soluble polyvalent metal salt is preferably dissolved in 100 g of water at 20 ° C. It is 0.1 g or more, more preferably 0.5 g or more.

The amount of the metal atom of the water-soluble polyvalent metal salt is preferably 0.1 or less, more preferably 0.01 or less, still more preferably 0.005, based on the mass ratio of the component (A) (polyvalent metal/(A)). Hereinafter, it is more preferably 0.001 or less. In addition, the content of the water-soluble polyvalent metal salt is preferably 0.1% by mass or less, more preferably 0.005% by mass or less, based on the metal atom, in the liquid oral composition of the bubble jet container of the present invention. Further, it is preferably 0.001% by mass or less, or the liquid oral composition contained in the bubble ejecting container of the present invention preferably contains no water-soluble polyvalent metal salt.

The liquid oral composition of the bubble spray container of the present invention preferably limits the content of citric acid from the viewpoint of forming a good bubble from the ejection of the container and maintaining a good fragrance. The content of the citric acid is preferably 0.08% by mass or less, more preferably 0.05% by mass or less, based on the liquid oral composition contained in the bubble ejecting container of the present invention, or the liquid oral composition of the bubble ejecting container of the present invention. Preferably, the material is limited to contain citric acid in the case of sodium citrate.

The liquid oral composition contained in the bubble ejecting container of the present invention may contain, in addition to the above components, a sodium alkyl sulfate of the above component (A) and a nonionic surfactant, in addition to the above components. Surfactants, perfumes, preservatives, binders, pigments, pigments, etc.

As an interface other than the sodium alkyl sulfate and the nonionic surfactant of the above component (A) The active agent may, for example, be an amphoteric surfactant. Specific examples of the amphoteric surfactant include acetic acid betaine such as lauryl dimethylaminoacetate betaine; 2-alkyl-N-carboxymethyl- Imidazolinium betaine such as N-hydroxyethyl-N-imidazolium betaine; alkylsulfobetaine such as lauryl sulfobetaine or lauryl hydroxysultaine; coconut fatty amidamine propyl betaine Such as coconut oil fatty guanamine alkyl betaines; N-alkyl-1-hydroxyethyl imidazoline betaine sodium and other long-chain alkyl imidazolinium betaine.

Further, in terms of effectively increasing the amount of the cationic bactericide of the component (B) adsorbed on the inner surface of the oral cavity, and the taste, the content of the amphoteric surfactant is contained in the blister container of the present invention. The liquid oral composition is preferably less than 0.2% by mass, more preferably 0.15% by mass or less.

The fragrance may be an oil-soluble fragrance, and examples thereof include peppermint oil, spearmint oil, cinnamon oil, anise oil, eucalyptus oil, wintergreen oil, and cinnamon. Cassia oil, clove oil, thyme oil, sage oil, sage clary oil, nutmeg oil, fennel oil, lemon oil, orange oil, peppermint oil, cardamom Oil, raw hazelnut oil, basil oil, red orange oil, lime oil, lavender oil, rosemary oil, ginger oil, grapefruit oil, laurel oil, chamomile oil, ge Caraway oil, marjoram oil, bay oil, lemongrass oil, lemon balm oil, pimento berry oil, rose grass oil, mastic oil, pine needle Natural flavor ingredients such as pine needle oil, petitgrain oil, neroli oil, rose oil, jasmine oil, and flavoring ingredients obtained by processing the natural flavor components; menthol, long leaves Menthol, carvone, aniseed brain, cineole, methyl salicylate, cinnamon , eugenol, 3-1-menthyloxypropane-1,2-diol, thymol, citronellyl acetate, linalool, acetoacetate, geranyl alcohol, geranyl acetate, fragrant Molly, limonene, menthone, menthyl acetate, N-substituted-p-menthan-3-carboxamide, decene, octanal, citral, purlerone, carboxyl acetate, dihydrocarvyl acetate , anisaldehyde, benzaldehyde, camphor, lactone, ethyl acetate, ethyl butyrate, allyl cyclohexyl propionate, methyl ortho-benzoate, ethyl methyl phenyl glycidate, Vanillin, undecanoate, hexanal, butyl acetate, isoamyl acetate, hexenol, dimethyl sulfide, cyclocyclopentene, furfural, trimethylpyridinium , single ester ingredients such as ethyl lactate, methyl lactate, and ethyl thioacetate; strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, cream flavor, milk flavor, fruit blend flavor, tropical fruit flavor And so on to prepare the flavor component.

Examples of the preservative include isobutyl p-hydroxybenzoate, isopropyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, butyl p-hydroxybenzoate, propyl p-hydroxybenzoate, and p-hydroxybenzoate. Ester, benzoic acid, sodium benzoate, methyl salicylate, potassium sorbate, sodium dehydroacetate.

Examples of the binder include sodium alginate, sodium carboxymethylcellulose, carrageenan, sanmon gum, sodium polyacrylate, hydroxyethylcellulose, hydroxypropylcellulose, pectin, tragacanth, and arabic. Gum, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum, psyllium seed gum, polyvinyl alcohol, sodium chondroitin sulfate, methoxyethylene-cis-butyl The enedionic acid anhydride copolymer is preferably one or more selected from the group consisting of sodium carboxymethyl cellulose, carrageenan, triterpene, and hydroxyethyl cellulose. The content of the binder in the liquid oral composition of the bubble jet container of the present invention is preferably 0.5% by mass or less, more preferably 0.3% by mass, from the viewpoint of a moderate discharge pressure from the bubble ejecting container. the following.

The liquid oral composition of the present invention preferably has a pH of at least 3 at 25 ° C from the viewpoint of forming a good foam from the ejection of the container and preventing irritation, and further reduces odor or irritation. It is preferably 5 or more, more preferably 6 or more, still more preferably 7 or more, and is preferably 11.5 or less, more preferably 11 or less, still more preferably 10.8 or less.

Further, a pH adjusting agent may be used in that the pH of the liquid oral composition of the present invention is adjusted to the above range at 25 ° C. As the pH adjuster, It is selected from the group consisting of a carbonate or a bicarbonate; potassium hydroxide or sodium hydroxide; an organic acid such as citric acid, malic acid, lactic acid, tartaric acid or succinic acid; or one or more of these salts, here, In the case of using an organic acid, it is preferably used in combination with sodium acidate, and it is preferred to limit the content of the citric acid as described above. Or in the case of using citric acid, it is preferably used together with sodium citrate.

The liquid oral composition contained in the bubble discharge container of the present invention is filled in a bubble discharge container having a discharge port. When the liquid oral composition contained in the bubble ejecting container of the present invention is used, the liquid oral composition as a content is directly ejected into the oral cavity from the ejection port provided in the ejecting container, and the liquid is discharged through the ejection port. The oral composition is applied to the oral cavity in a foam form. Thereby, the liquid oral composition can be spread to various corners of the oral cavity while bringing a good foam quality, and the cationic disinfection of the component (B) can be effectively improved. The adsorption of the agent on the inner surface of the oral cavity.

The bubble discharge container which fills the liquid oral composition is preferably a non-aerosol type container as long as it is provided with a discharge port, and is preferably a non-aerosol type container from the viewpoint of easiness of control of discharge amount and control of foam quality. From the viewpoint of the foaming performance and the effectiveness of the compressed gas, an aerosol type container is preferred.

The non-aerosol type container is an atmospheric container which does not require a propellant such as a compressed gas, and examples of the container include a squeeze type container and a pump type container. These containers are preferably used in view of the fact that the content of the content is well formed into a bubble-like composition through the discharge port, and that the formed bubble has good retention or homogeneity, and the feeling of use is improved. The flow path of the contents from the container body to the discharge port is a container in which a sieve or a porous member provided with a plurality of small holes is interposed.

The squeeze container is formed by squeezing and deforming the main body portion of the deformable container body so that the air and the contents which are fed from the head space are mixed through the porous member as needed, thereby forming a bubble and The bubble is ejected from the ejection outlet. Specifically, an example For example, a container described in Japanese Laid-Open Patent Publication No. Hei. No. Hei. No. Hei. No. Hei. No. Hei.

In the pump type container, the pump head provided in the bubble ejector having the discharge port is configured to mix the air and the contents flowing in from the outside through the porous member as needed, thereby forming a bubble and causing the bubble to be sprayed. Export spouter. Usually, an air cylinder for allowing air to flow in from the outside and a liquid cylinder to be a flow path of the contents are provided, and a mixing chamber for mixing the air pumped by the pump head and the contents is provided. Specifically, for example, a container described in Japanese Laid-Open Patent Publication No. Hei. No. Hei. No. Hei.

The aerosol-type container is a container in which a compressed gas is filled as a propellant, and when a content is discharged from a discharge port, a bubble is formed while introducing a gas through a valve mechanism. As the compressed gas to be used, a gas containing 90% by mass or more of carbon dioxide is preferable.

The bubble ejecting container used in the present invention is preferably a non-aerosol container of a squeeze container or a pump container, from the viewpoint of usability, that is, a product which is easily ejected directly into the oral cavity from the ejection port, or The aerosol container is preferably a pump container from the viewpoint of foam performance, and is preferably a squeeze container, and more preferably a container, from the viewpoint of excellent foam properties and convenience or portability. A squeeze container of a screen of #90 to #305 is provided in the flow path of the contents up to the discharge port.

The present invention is also useful as an oral surface adsorption promoter which is a cationic bactericide having a foaming preparation as an active ingredient, and the blister preparation contains the above components (A), (B) and (C): (A) alkyl sulfate 0.05% by mass or more and 1% by mass or less of sodium, (B) 0.001% by mass or more and 0.1% by mass or less of the cationic bactericide, and (C) water, and the mass ratio of the component (B) to the component (A) ((B) And (A)) is 0.005 or more and 0.7 or less, and the content of the nonionic surfactant is 1.2% by mass or less.

The content, the mass ratio, and other components which may be contained in the above-mentioned components (A), (B) and (C) in the foam preparation are the same as those in the liquid ejecting container in the above-mentioned bubble ejecting container. The oral cavity surface adsorption promoter of the cationic bactericidal agent of the present invention can effectively increase the adsorption amount of the cationic bactericide on the inner surface of the oral cavity as described above by using the blister preparation as an active ingredient, and has high usefulness. Preparation.

Further, in the case of application to the oral cavity in the form of a foam, it is preferred to fill the oral cavity surface adsorption promoter in the bubble ejection container in the same manner as the liquid oral composition in the above-described bubble ejection container.

In the above-described embodiment of the present invention, the liquid oral composition contained in the following bubble ejecting container and the oral surface adsorbing agent of the cationic sterilizing agent are further disclosed.

[1] A liquid oral composition containing a component (A), (B), and (C): (A) sodium alkyl sulfate of 0.05% by mass or more and 1% by mass or less, (B) a cationic bactericide: 0.001% by mass or more and 0.1% by mass or less, and (C) water, and a mass ratio ((B)/(A)) of the component (B) to the component (A) is 0.005 or more and 0.7 or less. Further, the content of the nonionic surfactant is 1.2% by mass or less.

[2] The liquid oral composition according to the above [1], wherein the component (A) is preferably one or two selected from the group consisting of sodium lauryl sulfate and sodium myristyl sulfate. Good for sodium lauryl sulfate.

[3] The liquid oral composition according to the above [1] or [2], wherein the content of the component (A) is preferably 0.08% by mass or more, more preferably 0.1% by mass or more, and further preferably It is 0.7% by mass or less, more preferably 0.5% by mass or less.

[4] The liquid oral composition according to any one of the above [1] to [3] wherein the component (B) is one selected from the group consisting of cetylpyridinium chloride and benzethonium chloride. Or 2 kinds.

[5] The liquid oral composition of the bubble ejecting container according to any one of the above [1] to [4] The content of the component (B) is preferably 0.005% by mass or more, more preferably 0.01% by mass or more, and is preferably 0.07% by mass or less, and more preferably 0.05% by mass or less.

[6] The liquid oral composition of the bubble ejecting container according to any one of the above [1] to [5] wherein the mass ratio of the component (B) to the component (A) ((B)/(A)) It is preferably 0.01 or more, more preferably 0.02 or more, and is preferably 0.5 or less, more preferably 0.4 or less, still more preferably 0.3 or less.

[7] The liquid oral composition according to any one of the above [1] to [6] wherein the content of the component (C) is preferably 55 mass% or more, more preferably 60 mass% or more. Further, it is preferably 65 mass% or more, and is preferably 99 mass% or less, more preferably 98. mass% or less, still more preferably 98 mass% or less.

[8] The liquid oral composition according to any one of the above [1] to [7] wherein the content of the nonionic surfactant is preferably 1% by mass or less, more preferably 0.8% by mass. Hereinafter, it is more preferably 0.5% by mass or less, still more preferably 0.2% by mass or less, or no nonionic surfactant.

[9] The liquid oral composition of the bubble ejecting container according to any one of the above [1] to [8], wherein the mass ratio of the nonionic surfactant to the component (B) (nonionic surfactant / ( B)) is preferably 100 or less, more preferably 50 or less, further preferably 20 or less, and still more preferably 10 or less.

[10] The liquid oral composition according to any one of the above [1] to [9], wherein the content of the ethanol is preferably 2.7% by mass or less, more preferably 2.5% by mass or less, and further It is preferably 2.2% by mass or less, more preferably 2% by mass or less, and more preferably 0% by mass or more, preferably 1% by mass or more, or no ethanol.

[11] The liquid oral composition according to any one of the above [1] to [10] wherein the total content of the ethanol and the nonionic surfactant is more preferably 2.7% by mass or less, and further preferably. It is 2.5% by mass or less, more preferably 2.2% by mass or less, and particularly preferably 2% by mass or less.

[12] The liquid oral composition according to any one of the above [1] to [11], wherein the content of the abrasive powder is preferably 0.5% by mass or less, more preferably 0.4% by mass or less. Further, it is preferably 0.3% by mass or less, more preferably 0.2% by mass or less, and more preferably 0% by mass or no abrasive powder.

[13] The liquid oral composition according to any one of the above [1] to [12] wherein the content of the solid sugar alcohol at 20 ° C is preferably 1% by mass or less, more preferably It is 0.5% by mass or less, more preferably 0.1% by mass or less, still more preferably 0.05% by mass or less, or no sugar alcohol which is solid at 20 °C.

[14] The liquid oral composition of the bubble ejecting container according to any one of the above [1] to [13] wherein the ratio of the metal atom of the water-soluble polyvalent metal salt to the mass ratio of the component (A) ( The polyvalent metal/(A)) is preferably 0.1 or less, more preferably 0.01 or less, still more preferably 0.005 or less, still more preferably 0.001 or less.

[15] The liquid oral composition according to any one of the above [1] to [14] wherein the content of citric acid is preferably 0.08% by mass or less, more preferably 0.05% by mass or less, or The liquid oral composition of the bubble ejection container of the present invention is preferably limited to contain citric acid in the case of containing sodium citrate.

[16] The liquid oral composition according to any one of the above [1] to [15] wherein the content of the amphoteric surfactant is preferably less than 0.2% by mass, more preferably 0.15% by mass. the following.

[17] The liquid oral composition according to any one of the above [1] to [16] wherein the content of the binder is preferably 0.5% by mass or less, more preferably 0.3% by mass or less.

[18] The liquid oral composition of the bubble ejecting container according to any one of the above [1] to [17], wherein the pH at 25 ° C is preferably 3 or more, preferably 5 or more, more preferably It is 6 or more, more preferably 7 or more, and is preferably 11.5 or less, more preferably 11 or less, still more preferably 10.8 or less.

[19] The liquid oral composition of the bubble ejecting container according to any one of the above [1] to [18] The substance is filled in a bubble ejection container.

[20] The liquid oral composition according to any one of the above [1] to [19] wherein the bubble ejection container is a non-aerosol container squeeze container or pump container, or an aerosol container.

[21] The use of a liquid oral composition in a bubble ejecting container according to any one of the above [1] to [20], which is used in a bubbly form in an oral cavity.

[22] The use of a liquid oral composition according to any one of the above [1] to [20], which is used for adsorbing a cationic bactericide on the inner surface of the oral cavity.

[23] Use of a liquid oral composition in a bubble ejecting container according to any one of the above [1] to [20], which is used for producing an oral cavity surface adsorption promoter of a cationic bactericide.

[24] A liquid oral composition according to any one of the above [1] to [20], wherein the liquid oral composition is sprayed in a bubble form and is sprayed. Applied to the mouth.

[25] A method for promoting an oral cavity surface adsorption of a cationic bactericidal agent, which is obtained by bubbling and applying a liquid oral composition in a bubble ejection container according to any one of the above [1] to [20] In the mouth.

[26] An oral surface adsorption promoter for a cationic bactericide, which comprises a foam preparation as an active ingredient, the blister preparation comprising the following components (A), (B) and (C): (A) alkyl sulphate 0.05% by mass or more and 1% by mass or less of sodium, (B) 0.001% by mass or more and 0.1% by mass or less of the cationic bactericide, and (C) water, and the mass ratio of the component (B) to the component (A) ((B) And (A)) is 0.005 or more and 0.7 or less, and the content of the nonionic surfactant is 1.2% by mass or less.

[27] The oral surface adsorption promoter of the cationic bactericide according to the above [26], wherein the component (A) is preferably one or two selected from the group consisting of sodium lauryl sulfate and sodium myristyl sulfate. More preferably sodium lauryl sulfate.

[28] The oral surface adsorption promoter of the cationic bactericide according to [26] or [27], wherein the content of the component (A) is preferably 0.08% by mass or more, more preferably 0.1% by mass or more, and more preferably The content is preferably 0.7% by mass or less, more preferably 0.5% by mass or less.

[29] The oral surface adsorption promoter of the cationic bactericide according to any one of [26] to [28] wherein the component (B) is one selected from the group consisting of cetylpyridinium chloride and benzethonium chloride. Species or 2 species.

[30] The oral surface adsorption promoter of the cationic bactericide according to any one of the above [26], wherein the content of the component (B) is preferably 0.005% by mass or more, more preferably 0.01% by mass. The above is preferably 0.07% by mass or less, and more preferably 0.05% by mass or less.

[31] The oral surface adsorption promoter of the cationic bactericide according to any one of the above [26] to [30], wherein the mass ratio of the component (B) to the component (A) ((B)/(A) It is preferably 0.01 or more, more preferably 0.02 or more, and is preferably 0.5 or less, more preferably 0.4 or less, still more preferably 0.3 or less.

[32] The oral surface adsorption promoter of the cationic bactericide according to any one of the above [26], wherein the content of the component (C) is preferably 55 mass% or more, more preferably 60 mass%. The above is more preferably 65% by mass or more, and is preferably 99% by mass or less, more preferably 98.5% by mass or less, and still more preferably 98% by mass or less.

[33] The oral surface adsorption promoter of the cationic bactericide according to any one of [26] to [32] wherein the content of the nonionic surfactant is preferably 1% by mass or less, more preferably 0.8% by mass. % or less is further preferably 0.5% by mass or less, more preferably 0.2% by mass or less, or no nonionic surfactant.

[34] The oral surface adsorption promoter of the cationic bactericide according to any one of [26] to [33], wherein the mass ratio of the nonionic surfactant to the component (B) (nonionic surfactant/ (B)) is preferably 100 or less, more preferably 50 or less, further preferably 20 or less, and still more preferably 10 or less.

[35] The oral surface of the cationic bactericide according to any one of the above [26] to [34] The adsorption accelerator, wherein the content of the ethanol is preferably 2.7 mass% or less, more preferably 2.5% by mass or less, further preferably 2.2 mass% or less, further preferably 2 mass% or less, and more preferably more than 0 mass%. It is preferably 1% by mass or more or no ethanol.

[36] The oral surface adsorption promoter of the cationic bactericide according to any one of [26] to [35], wherein the total content of the ethanol and the nonionic surfactant is more preferably 2.7% by mass or less, and further It is preferably 2.5% by mass or less, more preferably 2.2% by mass or less, and particularly preferably 2% by mass or less.

[37] The oral surface adsorption promoter of the cationic bactericide according to any one of the above [26], wherein the content of the abrasive powder is preferably 0.5% by mass or less, more preferably 0.4% by mass. In the following, it is preferably 0.3% by mass or less, more preferably 0.2% by mass or less, and more preferably 0% by mass or no abrasive powder.

[38] The oral surface adsorption promoter of the cationic bactericide according to any one of the above [26], wherein the content of the solid sugar alcohol at 20 ° C is preferably 1% by mass or less. It is preferably 0.5% by mass or less, more preferably 0.1% by mass or less, still more preferably 0.05% by mass or less, or no sugar alcohol which is solid at 20 °C.

[39] The oral surface adsorption promoter of the cationic bactericide according to any one of the above [26] to [38], wherein the ratio of the metal atom of the water-soluble polyvalent metal salt to the mass ratio of the component (A) The polyvalent metal/(A) is preferably 0.1 or less, more preferably 0.01 or less, still more preferably 0.005 or less, still more preferably 0.001 or less.

[40] The oral surface adsorption promoter of the cationic bactericide according to any one of [26] to [39] wherein the amphoteric surfactant is preferably less than 0.2% by mass, more preferably 0.15 by mass. %the following.

[41] The oral surface adsorption promoter of the cationic bactericide according to any one of the above [26], wherein the content of the binder is preferably 0.5% by mass or less, more preferably 0.3% by mass or less.

[42] The oral surface of the cationic bactericide according to any one of the above [26] to [41] The adsorption accelerator preferably has a pH of 3 or more, preferably 5 or more, more preferably 6 or more, further preferably 7 or more, and more preferably 11.5 or less, more preferably 11 or less, at 25 ° C. More preferably, it is 10.8 or less.

[43] The oral surface adsorption promoter of the cationic bactericide according to any one of [26] to [42] above, which is filled in a bubble ejection container.

[44] The oral surface adsorption promoter of the cationic bactericide according to [43] above, wherein the bubble ejection container is a non-aerosol container squeeze container or a pump container, or an aerosol container.

[45] Use of the oral surface adsorption promoter of the cationic bactericide according to any one of [26] to [44], which is used for application to the oral cavity in a foam form.

[46] A method of using an oral cavity surface adsorption promoter of a cationic bactericide according to any one of the above [26] to [44], wherein the oral surface adsorption promoter is blister-like Spray and apply to the mouth.

[47] A method for promoting an oral surface adsorption of a cationic bactericide, which is obtained by bubbling and applying an oral surface adsorption promoter of a cationic bactericide according to any one of the above [26] to [44] In the mouth.

[Examples]

Hereinafter, the present invention will be specifically described based on examples. In addition, as long as it is not specifically shown in the table, the content of each component represents mass %.

[Examples 1 to 8 and Comparative Examples 1 to 8]

Liquid oral compositions were prepared according to the formulations shown in Tables 1-2.

Further, in Examples 1 to 8, the obtained liquid oral compositions were filled in a pump foaming container (large and canned); F5 pump was foamed; sieve: 2; sieve size: #255 /#255) The contents were ejected from the discharge port, and 1.0 g was taken as a blister sample. In Comparative Examples 1 to 8, 1.0 g of each liquid oral composition obtained was used in the form of a liquid sample without being filled in a container.

Then, using each of the obtained samples, a polyfluorene oxide sheet was used as a model of the oral cavity mucosa, and the amount of adsorption of the cationic bactericide on the polyfluorene oxide sheet was measured in accordance with the following method. Further, the amount of adsorption of the cationic bactericidal agent in Table 1 on the polyfluorene oxide sheet is the cationic sterilization of the example in which the adsorption amount of the cationic bactericide of the comparative example corresponding to each example is set to 100. The amount of adsorption of the agent is expressed as an index to show the advantage of the composition of the foamed composition relative to the liquid composition.

Further, HAP (hydroxyapatite) powder was used as a model of the tooth surface, and the amount of adsorption of the cationic bactericide on the HAP powder was measured by the following method. In addition, the amount of the cationic bactericide in Table 2 adsorbed on the HAP powder is a cationic bactericide of the example in which the amount of the cationic bactericide of the comparative example corresponding to each example is set to 100. The amount of adsorption is expressed as an index. The results are shown in Tables 1 and 2.

Determination of Adsorption Capacity of Cationic Fungicides on Polyfluorene Oxide Tablets

The cylindrical tube (cross-sectional area: 7.07×10 ^-4 m ² ) was placed on the surface of the polyfluorene oxide sheet with one of the open end faces adhered to the surface of the polyfluorene oxide sheet (500 mm × 500 mm, thickness 0.1 mm, manufactured by TIGERS POLYMER) )on. Then, 1.0 g of each sample was thrown into the cylindrical tube from the other end of the cylindrical tube so that the contact area between the sample and the polyfluorene oxide sheet became the same as the inner cross-sectional area of the cylindrical tube, and the application was carried out. On the surface of the polyfluorene oxide sheet inside the cylindrical tube surrounded by the circumferential surface of the cylindrical tube, the sample was placed in contact with the polyfluorene oxide sheet for 2 minutes.

Each of the obtained polyfluorene oxide sheets was immersed in ion-exchanged water in a 50 mL beaker for 30 seconds, and then taken out from the beaker, and 1.5 mL of an extract (mobile phase shown below) was applied for 30 seconds to recover a cationic bactericide. The amount of the cationic bactericide (μg/m ² ) was measured by high performance liquid chromatography (HPLC) under the following measurement conditions.

<HPLC measurement conditions>

Device: Hitachi High Performance Liquid Chromatography La chromElite

Detector: UV spectrophotometer (measuring wavelength: 260 nm)

Pipe column: CAPCELL PAK SCX UG80 (4.6×100mm, 5μm) (Shiseido (share))

Column temperature: 40 ° C

Mobile phase: methanol/water mixture (3:1) +0.05 mol/L sodium perchlorate-hydrate

Flow rate: 1.2mL/min

"Determination of the adsorption amount of cationic bactericide on HAP powder"

0.1 g of HAP powder (HAP200 (Taihei Chemical Industry), specific surface area: 9.97 m ^{2 /} g) was placed in a 50 mL tube, and then 1.0 g of each sample was further charged. Then, the contents of the respective tubes were stirred for 2 minutes using a centrifugal separator/vortex mixer (SHIBATA TTM-1), and then centrifuged at 25 ° C for 10 minutes at 3000 rpm. After the centrifugation, the supernatant was discarded, and then 1 mL of ion-exchanged water was poured into the tube and stirred for another 30 seconds, and the same centrifugal separation was performed again, and the supernatant was discarded, and the stirring and centrifugation were repeated twice. Processing.

Apply 1.5 mL of the extract (mobile phase shown below) to the contents of the tube after discarding the supernatant for 30 seconds to recover the cationic bactericide by high performance liquid chromatography (HPLC). The amount of the cationic bactericide (ng/m ² ) was measured in accordance with the same measurement conditions as above.

[Examples 9 to 13 and Comparative Examples 10 to 11]

The liquid oral composition was prepared according to the formulation shown in Table 3, and then the obtained liquid oral composition was filled in a pump foaming container in the same manner as in Example 1 to make the contents It was sprayed from the discharge port and taken in the form of a blister sample of 1.0 g.

Then, using each of the obtained samples, the amount of adsorption of the cationic bactericide on the polyfluorene oxide sheet and the amount of adsorption of the cationic bactericide on the HAP (hydroxyapatite) powder were measured in accordance with the above method.

The results are shown in Table 3.

"Evaluation of bubble performance"

Using the samples obtained in Examples 1, 4, and 13, the foam properties were evaluated in the following manner.

Five sheets of filter paper (manufactured by ADVANTEC, No. 1, 70 mm) were placed one on top of the other, and 1.0 g of each of the samples prepared by using a bubble discharge container was placed on five sheets of filter paper. The bubble of each sample was placed on the filter paper and allowed to stand for 10 seconds, after which the bubbles were wiped by Kimwipe (Soft Wiper S150 Box). The weight (g) of the sample contained in the filter paper after the wiping was wiped was measured and set as the discharge amount (g). With drainage rate (%) = The liquid discharge rate was calculated by the method of (liquid discharge amount (g)) / (1.0 (g)) × 100. The higher the drainage rate, the lower the durability of the foam.

The results are shown in Table 4. As shown in Table 4, it was confirmed that the larger the mass ratio ((B)/(A)) of the component (B) to the component (A), the higher the liquid discharge rate.

[Example 14 and Comparative Example 14]

The liquid oral composition was prepared according to the formulation shown in Table 5, and then the obtained liquid oral composition was filled in a pump foam container in the same manner as in Example 1, and the contents were ejected from the discharge port to form a bubble. The sample was taken in the form of 1.0 g.

Then, using each of the obtained samples, the amount of adsorption of the cationic bactericide on the polyfluorene oxide sheet was measured in accordance with the above method.

The results are shown in Table 5.

Taste Evaluation

The taste evaluation was carried out using the liquid oral compositions obtained in Examples 5 to 7. Specifically, the number of mL of each of the liquid oral compositions was contained in the oral cavity, and the taste evaluation of Examples 5 and 7 was carried out based on the taste evaluation (the presence or absence of taste and irritation) of Example 6. Furthermore, the evaluation was performed by one person.

The results are shown in Table 6. Example 5 is the same taste as Example 6, but Example 7 clearly perceived odor compared to Example 6, and also strongly felt the irritation.

Claims (9)

A liquid oral composition containing a component (A), (B), and (C): (A) sodium alkyl sulfate 0.05% by mass or more and 1% by mass or less, (B) cationicity The bactericidal agent is 0.001% by mass or more and 0.1% by mass or less, and (C) water, and the mass ratio ((B)/(A)) of the component (B) to the component (A) is 0.005 or more and 0.7 or less, and the nonionic The content of the surfactant is 1.2% by mass or less. The liquid oral composition according to claim 1, wherein the content of the ethanol is 2.7% by mass or less. A liquid oral composition according to claim 1 or 2, which has a pH of 3 or more at 25 ° C. The liquid oral composition according to claim 1 or 2, wherein the content of the solid sugar alcohol at 20 ° C is 1% by mass or less. The liquid oral composition according to claim 1 or 2, wherein the mass ratio of the metal atom of the water-soluble polyvalent metal salt to the component (A) (polyvalent metal/(A)) is 0.1. the following. The liquid oral composition according to claim 1 or 2, wherein the component (B) is one or two selected from the group consisting of cetylpyridinium chloride and benzethonium chloride. The liquid oral composition according to claim 1 or 2, wherein the content of the abrasive powder is 0.5% by mass or less. A liquid oral composition according to claim 1 or 2, wherein the bubble ejection container is a non-aerosol container of a squeeze container or a pump container, or an aerosol container. Oral internal surface adsorption promoter of cationic bactericide, which is in the form of a blister preparation The active ingredient contains the following components (A), (B), and (C): (A) sodium alkyl sulfate 0.05% by mass or more and 1% by mass or less, and (B) cationic bactericide 0.001% by mass. The above ratio is 0.1% by mass or less, and (C) water, and the mass ratio ((B)/(A)) of the component (B) to the component (A) is 0.005 or more and 0.7 or less, and the content of the nonionic surfactant is It is 1.2% by mass or less.