JP4996845B2 - Foam-type fluorine coating agent - Google Patents
Foam-type fluorine coating agent Download PDFInfo
- Publication number
- JP4996845B2 JP4996845B2 JP2005329515A JP2005329515A JP4996845B2 JP 4996845 B2 JP4996845 B2 JP 4996845B2 JP 2005329515 A JP2005329515 A JP 2005329515A JP 2005329515 A JP2005329515 A JP 2005329515A JP 4996845 B2 JP4996845 B2 JP 4996845B2
- Authority
- JP
- Japan
- Prior art keywords
- mass
- sodium
- coating agent
- foam
- fluorine coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title claims description 37
- 229910052731 fluorine Inorganic materials 0.000 title claims description 37
- 239000011737 fluorine Substances 0.000 title claims description 37
- 239000011248 coating agent Substances 0.000 title claims description 31
- -1 hydroxybenzoic acid ester Chemical class 0.000 claims description 42
- 239000000203 mixture Substances 0.000 claims description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 17
- 125000000217 alkyl group Chemical group 0.000 claims description 17
- 239000011734 sodium Substances 0.000 claims description 17
- 229910052708 sodium Inorganic materials 0.000 claims description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 14
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 11
- 235000019441 ethanol Nutrition 0.000 claims description 11
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 8
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 7
- 239000002202 Polyethylene glycol Substances 0.000 claims description 7
- 229910052799 carbon Inorganic materials 0.000 claims description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims description 7
- 238000009826 distribution Methods 0.000 claims description 7
- 239000012528 membrane Substances 0.000 claims description 7
- 229920001223 polyethylene glycol Polymers 0.000 claims description 7
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- 229940085991 phosphate ion Drugs 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- 235000013772 propylene glycol Nutrition 0.000 claims description 3
- 239000006260 foam Substances 0.000 description 31
- 238000011156 evaluation Methods 0.000 description 26
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 16
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 16
- 239000003945 anionic surfactant Substances 0.000 description 14
- 150000003839 salts Chemical class 0.000 description 14
- 229940091249 fluoride supplement Drugs 0.000 description 12
- 235000014113 dietary fatty acids Nutrition 0.000 description 10
- 239000000194 fatty acid Substances 0.000 description 10
- 229930195729 fatty acid Natural products 0.000 description 10
- 239000000796 flavoring agent Substances 0.000 description 10
- 238000001556 precipitation Methods 0.000 description 10
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 9
- 235000019634 flavors Nutrition 0.000 description 9
- 238000002360 preparation method Methods 0.000 description 9
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 9
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 235000013024 sodium fluoride Nutrition 0.000 description 8
- 239000011775 sodium fluoride Substances 0.000 description 8
- 239000004094 surface-active agent Substances 0.000 description 8
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 7
- 239000003205 fragrance Substances 0.000 description 7
- 238000002156 mixing Methods 0.000 description 7
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N N-methylaminoacetic acid Natural products C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 6
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- 210000004379 membrane Anatomy 0.000 description 6
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 6
- 150000005846 sugar alcohols Polymers 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 229920001214 Polysorbate 60 Polymers 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 238000007796 conventional method Methods 0.000 description 5
- 210000003298 dental enamel Anatomy 0.000 description 5
- 235000003599 food sweetener Nutrition 0.000 description 5
- 239000003765 sweetening agent Substances 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 4
- 108010077895 Sarcosine Proteins 0.000 description 4
- 150000001298 alcohols Chemical class 0.000 description 4
- 229940024606 amino acid Drugs 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 238000013329 compounding Methods 0.000 description 4
- 229910000397 disodium phosphate Inorganic materials 0.000 description 4
- 235000019800 disodium phosphate Nutrition 0.000 description 4
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 4
- 230000007794 irritation Effects 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- 229940085605 saccharin sodium Drugs 0.000 description 4
- 229940043230 sarcosine Drugs 0.000 description 4
- 239000002562 thickening agent Substances 0.000 description 4
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 4
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 3
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 3
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 description 3
- 239000004386 Erythritol Substances 0.000 description 3
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 3
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 3
- 125000002252 acyl group Chemical group 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 3
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 3
- 235000019414 erythritol Nutrition 0.000 description 3
- 229940009714 erythritol Drugs 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 3
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 210000002200 mouth mucosa Anatomy 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 239000002244 precipitate Substances 0.000 description 3
- 239000003380 propellant Substances 0.000 description 3
- 229910001415 sodium ion Inorganic materials 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 229940074410 trehalose Drugs 0.000 description 3
- 239000000811 xylitol Substances 0.000 description 3
- 235000010447 xylitol Nutrition 0.000 description 3
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 3
- 229960002675 xylitol Drugs 0.000 description 3
- 229940058015 1,3-butylene glycol Drugs 0.000 description 2
- DXDTUQXKMVJYAM-UHFFFAOYSA-N 2-aminoacetic acid;potassium Chemical compound [K].NCC(O)=O DXDTUQXKMVJYAM-UHFFFAOYSA-N 0.000 description 2
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 2
- 239000005770 Eugenol Substances 0.000 description 2
- ZYEMGPIYFIJGTP-UHFFFAOYSA-N O-methyleugenol Chemical compound COC1=CC=C(CC=C)C=C1OC ZYEMGPIYFIJGTP-UHFFFAOYSA-N 0.000 description 2
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000005844 Thymol Substances 0.000 description 2
- 239000000443 aerosol Substances 0.000 description 2
- 150000008051 alkyl sulfates Chemical class 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- XJHCXCQVJFPJIK-UHFFFAOYSA-M caesium fluoride Chemical compound [F-].[Cs+] XJHCXCQVJFPJIK-UHFFFAOYSA-M 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- MWKFXSUHUHTGQN-UHFFFAOYSA-N decan-1-ol Chemical compound CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 2
- 229960002217 eugenol Drugs 0.000 description 2
- 238000005187 foaming Methods 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- PQXKHYXIUOZZFA-UHFFFAOYSA-M lithium fluoride Chemical compound [Li+].[F-] PQXKHYXIUOZZFA-UHFFFAOYSA-M 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 2
- 235000019799 monosodium phosphate Nutrition 0.000 description 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 2
- 229920001451 polypropylene glycol Polymers 0.000 description 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
- ONQDVAFWWYYXHM-UHFFFAOYSA-M potassium lauryl sulfate Chemical compound [K+].CCCCCCCCCCCCOS([O-])(=O)=O ONQDVAFWWYYXHM-UHFFFAOYSA-M 0.000 description 2
- 229940116985 potassium lauryl sulfate Drugs 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 2
- 239000001488 sodium phosphate Substances 0.000 description 2
- XZTJQQLJJCXOLP-UHFFFAOYSA-M sodium;decyl sulfate Chemical compound [Na+].CCCCCCCCCCOS([O-])(=O)=O XZTJQQLJJCXOLP-UHFFFAOYSA-M 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 150000008163 sugars Chemical class 0.000 description 2
- 229960000790 thymol Drugs 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 2
- 235000019798 tripotassium phosphate Nutrition 0.000 description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 2
- 235000019801 trisodium phosphate Nutrition 0.000 description 2
- BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- KRLBLPBPZSSIGH-CSKARUKUSA-N (6e)-3,7-dimethylnona-1,6-dien-3-ol Chemical compound CC\C(C)=C\CCC(C)(O)C=C KRLBLPBPZSSIGH-CSKARUKUSA-N 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- WUOACPNHFRMFPN-SECBINFHSA-N (S)-(-)-alpha-terpineol Chemical compound CC1=CC[C@@H](C(C)(C)O)CC1 WUOACPNHFRMFPN-SECBINFHSA-N 0.000 description 1
- PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 description 1
- JCPGMXJLFWGRMZ-UHFFFAOYSA-N 1-(2-hydroxyphenyl)-3-phenylpropan-1-one Chemical compound OC1=CC=CC=C1C(=O)CCC1=CC=CC=C1 JCPGMXJLFWGRMZ-UHFFFAOYSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- GFOBSZSXQKGNMN-UHFFFAOYSA-N 2-[dodecanoyl(methyl)amino]ethanesulfonic acid;sodium Chemical compound [Na].CCCCCCCCCCCC(=O)N(C)CCS(O)(=O)=O GFOBSZSXQKGNMN-UHFFFAOYSA-N 0.000 description 1
- NGOZDSMNMIRDFP-UHFFFAOYSA-N 2-[methyl(tetradecanoyl)amino]acetic acid Chemical compound CCCCCCCCCCCCCC(=O)N(C)CC(O)=O NGOZDSMNMIRDFP-UHFFFAOYSA-N 0.000 description 1
- ROJFMKKNPSHGIE-UHFFFAOYSA-N 2-aminoacetic acid;hydrofluoride Chemical compound F.NCC(O)=O ROJFMKKNPSHGIE-UHFFFAOYSA-N 0.000 description 1
- DHBPAQUDNKLCEJ-UHFFFAOYSA-N 2-hydroxybenzoic acid;phenol Chemical class OC1=CC=CC=C1.OC(=O)C1=CC=CC=C1O DHBPAQUDNKLCEJ-UHFFFAOYSA-N 0.000 description 1
- NBDYSLCMCUDINP-UHFFFAOYSA-N 3-[dodecanoyl(methyl)amino]propanoic acid;sodium Chemical compound [Na].CCCCCCCCCCCC(=O)N(C)CCC(O)=O NBDYSLCMCUDINP-UHFFFAOYSA-N 0.000 description 1
- PISXGJRFTFUJJV-UHFFFAOYSA-N 3-[hexadecanoyl(methyl)amino]propanoic acid Chemical compound CCCCCCCCCCCCCCCC(=O)N(C)CCC(O)=O PISXGJRFTFUJJV-UHFFFAOYSA-N 0.000 description 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 1
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 description 1
- DDFHBQSCUXNBSA-UHFFFAOYSA-N 5-(5-carboxythiophen-2-yl)thiophene-2-carboxylic acid Chemical compound S1C(C(=O)O)=CC=C1C1=CC=C(C(O)=O)S1 DDFHBQSCUXNBSA-UHFFFAOYSA-N 0.000 description 1
- LIFHMKCDDVTICL-UHFFFAOYSA-N 6-(chloromethyl)phenanthridine Chemical compound C1=CC=C2C(CCl)=NC3=CC=CC=C3C2=C1 LIFHMKCDDVTICL-UHFFFAOYSA-N 0.000 description 1
- JRLTTZUODKEYDH-UHFFFAOYSA-N 8-methylquinoline Chemical group C1=CN=C2C(C)=CC=CC2=C1 JRLTTZUODKEYDH-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 239000005973 Carvone Substances 0.000 description 1
- 229910021594 Copper(II) fluoride Inorganic materials 0.000 description 1
- 241000270722 Crocodylidae Species 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- GLWQRIMWMLJRIB-UHFFFAOYSA-N F.F.CCO Chemical compound F.F.CCO GLWQRIMWMLJRIB-UHFFFAOYSA-N 0.000 description 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- BJIOGJUNALELMI-ONEGZZNKSA-N Isoeugenol Natural products COC1=CC(\C=C\C)=CC=C1O BJIOGJUNALELMI-ONEGZZNKSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- 235000019501 Lemon oil Nutrition 0.000 description 1
- BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 description 1
- 235000019502 Orange oil Nutrition 0.000 description 1
- ILJYHJZWVIUCAH-UHFFFAOYSA-L P(=O)(OCC(O)CO)(OCC(O)CO)[O-].[Na+].[Na+].C(C(O)CO)OP(=O)(OCC(O)CO)[O-] Chemical compound P(=O)(OCC(O)CO)(OCC(O)CO)[O-].[Na+].[Na+].C(C(O)CO)OP(=O)(OCC(O)CO)[O-] ILJYHJZWVIUCAH-UHFFFAOYSA-L 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 description 1
- 229920001615 Tragacanth Polymers 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- FIOCZIMYKPQHOG-UHFFFAOYSA-J [F-].[Zr+4].[F].[F-].[F-].[F-] Chemical compound [F-].[Zr+4].[F].[F-].[F-].[F-] FIOCZIMYKPQHOG-UHFFFAOYSA-J 0.000 description 1
- AAQKCDIUEIKKTL-UHFFFAOYSA-N [Na].C(CCCCCCC)(=O)N(CCS(=O)(=O)O)C Chemical compound [Na].C(CCCCCCC)(=O)N(CCS(=O)(=O)O)C AAQKCDIUEIKKTL-UHFFFAOYSA-N 0.000 description 1
- RIPOBVVRXXYYBE-UHFFFAOYSA-N [Na].C(CCCCCCCCC)(=O)N(CCS(=O)(=O)O)C Chemical compound [Na].C(CCCCCCCCC)(=O)N(CCS(=O)(=O)O)C RIPOBVVRXXYYBE-UHFFFAOYSA-N 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010358 acesulfame potassium Nutrition 0.000 description 1
- 229960004998 acesulfame potassium Drugs 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- 229940022663 acetate Drugs 0.000 description 1
- KXKVLQRXCPHEJC-UHFFFAOYSA-N acetic acid trimethyl ester Natural products COC(C)=O KXKVLQRXCPHEJC-UHFFFAOYSA-N 0.000 description 1
- 231100000570 acute poisoning Toxicity 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- OVKDFILSBMEKLT-UHFFFAOYSA-N alpha-Terpineol Natural products CC(=C)C1(O)CCC(C)=CC1 OVKDFILSBMEKLT-UHFFFAOYSA-N 0.000 description 1
- 229940088601 alpha-terpineol Drugs 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
- LFVGISIMTYGQHF-UHFFFAOYSA-N ammonium dihydrogen phosphate Chemical compound [NH4+].OP(O)([O-])=O LFVGISIMTYGQHF-UHFFFAOYSA-N 0.000 description 1
- 229910000387 ammonium dihydrogen phosphate Inorganic materials 0.000 description 1
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 description 1
- 229940063953 ammonium lauryl sulfate Drugs 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 description 1
- 229910001634 calcium fluoride Inorganic materials 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 description 1
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 description 1
- 235000007746 carvacrol Nutrition 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229930007050 cineol Natural products 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- 239000010630 cinnamon oil Substances 0.000 description 1
- BJIOGJUNALELMI-ARJAWSKDSA-N cis-isoeugenol Chemical compound COC1=CC(\C=C/C)=CC=C1O BJIOGJUNALELMI-ARJAWSKDSA-N 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- GWFAVIIMQDUCRA-UHFFFAOYSA-L copper(ii) fluoride Chemical compound [F-].[F-].[Cu+2] GWFAVIIMQDUCRA-UHFFFAOYSA-L 0.000 description 1
- 125000003074 decanoyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 description 1
- QGSCPWWHMSCFOV-RRABGKBLSA-N dectaflur Chemical compound [F-].CCCCCCCC\C=C\CCCCCCCC[NH3+] QGSCPWWHMSCFOV-RRABGKBLSA-N 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 238000005115 demineralization Methods 0.000 description 1
- 230000002328 demineralizing effect Effects 0.000 description 1
- 208000002925 dental caries Diseases 0.000 description 1
- LNNWVNGFPYWNQE-GMIGKAJZSA-N desomorphine Chemical compound C1C2=CC=C(O)C3=C2[C@]24CCN(C)[C@H]1[C@@H]2CCC[C@@H]4O3 LNNWVNGFPYWNQE-GMIGKAJZSA-N 0.000 description 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- 229910000388 diammonium phosphate Inorganic materials 0.000 description 1
- 235000019838 diammonium phosphate Nutrition 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- RNPXCFINMKSQPQ-UHFFFAOYSA-N dicetyl hydrogen phosphate Chemical compound CCCCCCCCCCCCCCCCOP(O)(=O)OCCCCCCCCCCCCCCCC RNPXCFINMKSQPQ-UHFFFAOYSA-N 0.000 description 1
- 229940093541 dicetylphosphate Drugs 0.000 description 1
- PXLWOFBAEVGBOA-UHFFFAOYSA-N dihydrochalcone Natural products OC1C(O)C(O)C(CO)OC1C1=C(O)C=CC(C(=O)CC(O)C=2C=CC(O)=CC=2)=C1O PXLWOFBAEVGBOA-UHFFFAOYSA-N 0.000 description 1
- FXNRKXSSLJKNGH-UHFFFAOYSA-L dipotassium;fluoro-dioxido-oxo-$l^{5}-phosphane Chemical compound [K+].[K+].[O-]P([O-])(F)=O FXNRKXSSLJKNGH-UHFFFAOYSA-L 0.000 description 1
- HLJCWGPUCQTHFY-UHFFFAOYSA-H disodium;hexafluorotitanium(2-) Chemical compound [F-].[F-].[Na+].[Na+].F[Ti](F)(F)F HLJCWGPUCQTHFY-UHFFFAOYSA-H 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- RWSWOANLVTWMDE-UHFFFAOYSA-N dodecylazanium;fluoride Chemical compound F.CCCCCCCCCCCCN RWSWOANLVTWMDE-UHFFFAOYSA-N 0.000 description 1
- 239000010642 eucalyptus oil Substances 0.000 description 1
- 229940044949 eucalyptus oil Drugs 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- XPBBUZJBQWWFFJ-UHFFFAOYSA-N fluorosilane Chemical compound [SiH3]F XPBBUZJBQWWFFJ-UHFFFAOYSA-N 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229960002989 glutamic acid Drugs 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- OVYSUCIJMISHSX-UHFFFAOYSA-N hexan-1-amine;hydrofluoride Chemical compound F.CCCCCCN OVYSUCIJMISHSX-UHFFFAOYSA-N 0.000 description 1
- 229960002050 hydrofluoric acid Drugs 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 description 1
- 239000000832 lactitol Substances 0.000 description 1
- 235000010448 lactitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
- 229960003451 lactitol Drugs 0.000 description 1
- 239000010501 lemon oil Substances 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 239000008258 liquid foam Substances 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 239000004137 magnesium phosphate Substances 0.000 description 1
- 229960002261 magnesium phosphate Drugs 0.000 description 1
- 229910000157 magnesium phosphate Inorganic materials 0.000 description 1
- 235000010994 magnesium phosphates Nutrition 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 239000001683 mentha spicata herb oil Substances 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 150000004702 methyl esters Chemical class 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 229940116837 methyleugenol Drugs 0.000 description 1
- PRHTXAOWJQTLBO-UHFFFAOYSA-N methyleugenol Natural products COC1=CC=C(C(C)=C)C=C1OC PRHTXAOWJQTLBO-UHFFFAOYSA-N 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 235000019837 monoammonium phosphate Nutrition 0.000 description 1
- 150000007823 ocimene derivatives Chemical class 0.000 description 1
- 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229910001392 phosphorus oxide Inorganic materials 0.000 description 1
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical class [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920001748 polybutylene Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- JTXIPOLAHSBNJM-UHFFFAOYSA-M potassium;decyl sulfate Chemical compound [K+].CCCCCCCCCCOS([O-])(=O)=O JTXIPOLAHSBNJM-UHFFFAOYSA-M 0.000 description 1
- SQTLECAKIMBJGK-UHFFFAOYSA-I potassium;titanium(4+);pentafluoride Chemical compound [F-].[F-].[F-].[F-].[F-].[K+].[Ti+4] SQTLECAKIMBJGK-UHFFFAOYSA-I 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- JTDPJYXDDYUJBS-UHFFFAOYSA-N quinoline-2-carbohydrazide Chemical compound C1=CC=CC2=NC(C(=O)NN)=CC=C21 JTDPJYXDDYUJBS-UHFFFAOYSA-N 0.000 description 1
- 239000010668 rosemary oil Substances 0.000 description 1
- 229940058206 rosemary oil Drugs 0.000 description 1
- 239000010670 sage oil Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000003902 salicylic acid esters Chemical class 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 229940080236 sodium cetyl sulfate Drugs 0.000 description 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 1
- 229950005425 sodium myristyl sulfate Drugs 0.000 description 1
- 229940067741 sodium octyl sulfate Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 description 1
- WFRKJMRGXGWHBM-UHFFFAOYSA-M sodium;octyl sulfate Chemical compound [Na+].CCCCCCCCOS([O-])(=O)=O WFRKJMRGXGWHBM-UHFFFAOYSA-M 0.000 description 1
- UPUIQOIQVMNQAP-UHFFFAOYSA-M sodium;tetradecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCOS([O-])(=O)=O UPUIQOIQVMNQAP-UHFFFAOYSA-M 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 208000003265 stomatitis Diseases 0.000 description 1
- 229940117986 sulfobetaine Drugs 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical compound [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- XJPBRODHZKDRCB-UHFFFAOYSA-N trans-alpha-ocimene Natural products CC(=C)CCC=C(C)C=C XJPBRODHZKDRCB-UHFFFAOYSA-N 0.000 description 1
- BJIOGJUNALELMI-UHFFFAOYSA-N trans-isoeugenol Natural products COC1=CC(C=CC)=CC=C1O BJIOGJUNALELMI-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- KENFVQBKAYNBKN-UHFFFAOYSA-N trihexadecyl phosphate Chemical compound CCCCCCCCCCCCCCCCOP(=O)(OCCCCCCCCCCCCCCCC)OCCCCCCCCCCCCCCCC KENFVQBKAYNBKN-UHFFFAOYSA-N 0.000 description 1
- FDGZUBKNYGBWHI-UHFFFAOYSA-N trioctadecyl phosphate Chemical compound CCCCCCCCCCCCCCCCCCOP(=O)(OCCCCCCCCCCCCCCCCCC)OCCCCCCCCCCCCCCCCCC FDGZUBKNYGBWHI-UHFFFAOYSA-N 0.000 description 1
- OBKARMSLSGWHQK-UHFFFAOYSA-K tripotassium;2-hydroxypropane-1,2,3-tricarboxylate;dihydrate Chemical compound O.O.[K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O OBKARMSLSGWHQK-UHFFFAOYSA-K 0.000 description 1
- KPZYAGQLBFUTMA-UHFFFAOYSA-K tripotassium;phosphate;trihydrate Chemical compound O.O.O.[K+].[K+].[K+].[O-]P([O-])([O-])=O KPZYAGQLBFUTMA-UHFFFAOYSA-K 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
本発明は、空気と混合して多孔質膜を通過させることにより泡沫状として吐出する泡沫状フッ素塗布剤に関する。 The present invention relates to a foamy fluorine coating agent which is discharged as a foam by mixing with air and passing through a porous membrane.
歯のエナメル質表面にフッ化物を塗布するとエナメル質表面層のフッ素濃度が増加し、う蝕の発生を予防することができる。従来からフッ素塗布剤として、液体状またはゲル状の塗布剤が用いられている。しかし、液体状のものは綿球に染み込ませて歯面に塗布する方法がとられるため、処置に時間がかかり、効率性に問題がある。またゲル状のものは、ゲルを乗せたトレーを噛ませるトレー法を用いるため、簡便である反面、粘性が高いため行き渡り難い。さらにフッ素の急性中毒の危険性を考慮し、その使用量はできるだけ少なくなるようにしなければならない。 When fluoride is applied to the enamel surface of the tooth, the fluorine concentration in the enamel surface layer increases, and the occurrence of caries can be prevented. Conventionally, liquid or gel coating agents have been used as fluorine coating agents. However, since the liquid form is soaked in a cotton ball and applied to the tooth surface, the treatment takes time and there is a problem in efficiency. Moreover, since the gel-like thing uses the tray method which bites the tray on which the gel is placed, it is simple, but it is difficult to spread because of its high viscosity. Furthermore, considering the risk of acute poisoning of fluorine, the amount used must be minimized.
このような点を解決するため、最近、液体状フッ素塗布剤に噴射剤を配合してエアゾール容器に充填し、泡沫化する方法が提案された(特許文献1及び2参照)。泡沫化することにより、泡と歯の接触する面積を損なうことなく使用量を大きく減量することができる。しかし噴射剤として通常可燃性ガスが使用されており、口腔内での安全性に問題があるだけでなく、容器を容易に廃棄できないか、または再利用できない等といった環境の点からも好ましくない。一方、噴射剤を使用せずに泡沫化するには、組成物を空気と混合して多孔質膜を通過させることにより泡沫状として吐出する構造のフォーマー容器を用いる方法がある。該容器に充填した組成物は、「口腔用」分野において多数の特許が開示されており、また一般的な洗浄剤として開示されている技術がある(特許文献3〜6)。さらにエアゾール容器を用いず、フォーマー容器を用いた、フッ化物イオンを供給するフッ化物、リン酸イオン、アニオン界面活性剤、非イオン界面活性剤を含有する口腔用の泡沫状フッ素塗布剤が開示されている(特許文献7参照)。
しかし、単純にこれらの泡沫製剤にフッ素塗布剤で通常使用されているような高濃度フッ素を添加した場合、長時間低温の環境に放置、貯蔵しておくと、液体組成物が沈殿を生成したり白濁を生じたりし、フォーマー容器から泡沫状に吐出されなかったり、あるいは吐出されたとしても泡質が低下したり、フッ素塗布剤が公衆衛生の場においても歯科医療の場においても広く一般の人々に対して必要とされるものであるにもかかわらず製品化するのにコストがかかりすぎたりする等、実際使用できるような品質の泡沫状フッ素塗布剤を供給することができていない。特に長期間に、低温での環境下で貯蔵される場合に、沈殿等の析出物があると、泡沫状に吐出することが出来なくなるため、低温域でも安定な泡沫製剤が求められていた。 However, if high-concentration fluorine, which is usually used in fluorine coatings, is simply added to these foam preparations, the liquid composition will precipitate if left in a low-temperature environment for a long time. Or foaming from the foam container, or even if it is discharged, the foam quality deteriorates, and the fluorine coating agent is widely used in both public health and dentistry settings. Although it is necessary for people, it is too costly to produce a product, and it has not been possible to supply a foamy fluorine coating agent of a quality that can be actually used. In particular, when stored in an environment at a low temperature for a long period of time, if there is a precipitate such as a precipitate, it cannot be discharged in the form of a foam. Therefore, a stable foam preparation has been demanded even in a low temperature range.
本発明の目的は、上記事情に鑑みなされたもので、空気と混合して多孔質膜を通過させることにより泡沫状として吐出するフォーマー容器に充填した組成物において、低コストで、安定な泡保持力を有し、使用感に優れ、人体や環境に安全であり、なおかつ、高濃度のフッ化物イオンを含みながら、長時間低温の環境に放置、貯蔵しておいても白濁や沈殿を生じないで性状が安定である泡沫状フッ素塗布剤を提供することである。 The object of the present invention has been made in view of the above circumstances, and in a composition filled in a foam container that is mixed with air and passed through a porous membrane and discharged as a foam, it is possible to stably hold the foam at a low cost. Powerful, excellent in feeling of use, safe for human body and environment, and does not cause cloudiness or precipitation even when stored and stored in a low temperature environment for a long time while containing a high concentration of fluoride ions And providing a foamy fluorine coating agent having stable properties.
本発明者らは、上記目的を達成するために鋭意検討を重ねた結果、
フッ化物イオンを供給するフッ化物、
リン酸イオン、
アニオン界面活性剤を、各々、特定量含み
さらに水酸基を有する化合物を3種以上含有することによって、
白濁や沈殿を生じない性状安定性の良い泡沫状フッ素塗布剤が得られることを見出し、本発明を完成するに至った。
As a result of intensive studies to achieve the above object, the present inventors
Fluoride to supply fluoride ions,
Phosphate ion,
By containing three or more compounds each containing a specific amount of anionic surfactant and further having a hydroxyl group,
The present inventors have found that a foamy fluorine coating agent having good property stability that does not cause white turbidity or precipitation can be obtained, and the present invention has been completed.
すなわち、本発明は、
フッ化物イオンを0.5〜2質量%供給するフッ化物、
リン酸イオン0.01〜10質量%、
アニオン界面活性剤0.2〜5.0質量%含み
さらに水酸基を有する化合物を3種以上含む液体組成物を、
多孔質膜を有するフォーマー容器に充填してなり、この容器から吐出させる時、泡沫状となることを特徴とする泡沫状フッ素塗布剤を提供するものである。
That is, the present invention
Fluoride supplying 0.5-2% by mass of fluoride ions,
0.01-10% by mass of phosphate ions,
A liquid composition comprising 0.2 to 5.0% by mass of an anionic surfactant and further containing three or more compounds having a hydroxyl group,
The present invention provides a foam fluorine coating agent which is filled in a former container having a porous film and becomes foamed when discharged from the container.
本発明によれば、高濃度のフッ化物イオンを含有しながら吐出する泡が安定な泡保持力を有し、使用感に優れ、人体や環境に安全であり、かつ長時間低温の環境に放置、貯蔵しておいても白濁や沈殿を生じない性状の安定した泡沫状フッ素塗布剤を提供できる。 According to the present invention, the foam to be discharged while containing a high concentration of fluoride ions has a stable foam holding power, is excellent in feeling of use, is safe for the human body and the environment, and is left in a low temperature environment for a long time. Thus, it is possible to provide a stable foamy fluorine coating agent having a property that does not cause cloudiness or precipitation even when stored.
本発明の泡沫状フッ素塗布剤に用いるフッ化物は、フッ化物イオンを0.5〜2質量%供給する量を含有する。フッ化物イオンが0.5質量%より少なければ、エナメル質のフッ素の取込効果が小さく、2質量%より多ければフッ化物塗布剤としては不安定である。用いるフッ化物としては、特に限定されるものではないが、例えば、フッ化ナトリウム、フッ化カリウム、フッ化アンモニウム、フッ化カルシウム、フッ化銅、フッ化亜鉛、フッ化リチウム、フッ化セシウム、フッ化ジルコニウム、フッ化スズ、フッ化水素酸、モノフルオルリン酸ナトリウム、モノフルオルリン酸カリウム、フッ化チタンナトリウム、フッ化チタンカリウム、N’−オクタデシルトリメチレンジアミン−N,N,N’−トリス(2−エタノール)−ジヒドロフロライドや9−オクタデセニルアミン−ヒドロフロライド、ヘキシルアミンハイドロフルオライド、ラウリルアミンハイドロフルオライド、グリシンハイドロフルオライド、アラニンハイドロフルオライド、ヘキサフルオロケイ酸ナトリウム、フルオロシラン、フッ化ジアンミン銀などが挙げられ、これらは単独で、または2種以上を組み合わせて使用できる。これらのうち、好ましくはフッ化ナトリウム、フッ化水素酸のいずれか一方又は両方が選ばれる。 The fluoride used in the foamy fluorine coating agent of the present invention contains an amount for supplying 0.5 to 2% by mass of fluoride ions. If the fluoride ion is less than 0.5% by mass, the enamel fluorine uptake effect is small, and if it is more than 2% by mass, it is unstable as a fluoride coating agent. The fluoride to be used is not particularly limited. For example, sodium fluoride, potassium fluoride, ammonium fluoride, calcium fluoride, copper fluoride, zinc fluoride, lithium fluoride, cesium fluoride, fluorine Zirconium fluoride, tin fluoride, hydrofluoric acid, sodium monofluorophosphate, potassium monofluorophosphate, sodium titanium fluoride, potassium titanium fluoride, N′-octadecyltrimethylenediamine-N, N, N ′ -Tris (2-ethanol) -dihydrofluoride, 9-octadecenylamine-hydrofluoride, hexylamine hydrofluoride, laurylamine hydrofluoride, glycine hydrofluoride, alanine hydrofluoride, sodium hexafluorosilicate , Fluorosilane, fluorine Such as diammine silver and the like, which may be used alone or in combination of two or more. Of these, preferably one or both of sodium fluoride and hydrofluoric acid are selected.
また、本発明の泡沫状フッ素塗布剤はリン酸イオン0.01〜10質量%、さらに好ましくは、0.05〜5質量%を含有する。リン酸イオンが0.01質量%より少ないと、エナメル質の脱灰が著しくなり、10質量%を超えるとエナメル質の溶解を抑制する効果がそれ程増加しなくなり不経済であり、使用感が著しく劣る。これらのリン酸イオンを供給するリン酸化物としては、特に限定されるものではないが、例えば、リン酸、リン酸水素二ナトリウム、リン酸二水素ナトリウム、リン酸三ナトリウム、リン酸水素二カリウム、リン酸二水素カリウム、リン酸三カリウム、リン酸一水素アンモニウム、リン酸三カルシウム、リン酸ジグリセリル二ナトリウム、リン酸ジセチル、リン酸ジセチルアルミニウム、リン酸水素カルシウム、リン酸水素二アンモニウム、リン酸セチル、リン酸トレオイル、リン酸トリステアリル、リン酸トリパルミチル、リン酸二水素アンモニウム、リン酸マグネシウムなどが挙げられ、これらは単独で、または2種以上を組み合わせて使用できる。これらのうち、好ましくは、リン酸、リン酸水素二ナトリウム、リン酸二水素ナトリウム、リン酸三ナトリウム、リン酸水素二カリウム、リン酸二水素カリウム、リン酸三カリウムが選ばれる。 Moreover, the foamy fluorine coating agent of this invention contains 0.01-10 mass% of phosphate ions, More preferably, it contains 0.05-5 mass%. If the phosphate ion is less than 0.01% by mass, enamel demineralization is remarkable, and if it exceeds 10% by mass, the effect of inhibiting the dissolution of enamel is not increased so much, which is uneconomical and the feeling of use is remarkable. Inferior. Phosphorus oxides supplying these phosphate ions are not particularly limited. For example, phosphoric acid, disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, dipotassium hydrogen phosphate , Potassium dihydrogen phosphate, tripotassium phosphate, ammonium monohydrogen phosphate, tricalcium phosphate, disodium diglyceryl phosphate, dicetyl phosphate, dicetyl aluminum phosphate, calcium hydrogen phosphate, diammonium hydrogen phosphate Cetyl phosphate, treoyl phosphate, tristearyl phosphate, tripalmityl phosphate, ammonium dihydrogen phosphate, magnesium phosphate, and the like. These may be used alone or in combination of two or more. Of these, phosphoric acid, disodium hydrogen phosphate, sodium dihydrogen phosphate, trisodium phosphate, dipotassium hydrogen phosphate, potassium dihydrogen phosphate, and tripotassium phosphate are preferably selected.
本発明の泡沫状フッ素塗布剤に用いるアニオン界面活性剤は、特に限定されるものではないが、例えば、天然または合成の高級脂肪酸塩や、アルキル硫酸系、カルボン酸系、アミノ酸系、スルホコハク酸系、リン酸系界面活性剤などが挙げられる。好ましくはアルキル硫酸系、またアミノ酸系、スルホコハク酸系界面活性剤が選ばれる。その配合量は0.2〜5.0質量%であり、好ましくは0.3〜3質量%であり、さらに好ましくは0.3〜1質量%である。配合量が0.2質量%に満たないと良質な泡が得られず、また5質量%を超えると口腔内組織への刺激が強く香味を損なう。 The anionic surfactant used in the foamy fluorine coating agent of the present invention is not particularly limited, and examples thereof include natural or synthetic higher fatty acid salts, alkyl sulfates, carboxylic acids, amino acids, and sulfosuccinic acids. And phosphoric acid surfactants. Alkyl sulfate-based, amino acid-based, and sulfosuccinic acid-based surfactants are preferably selected. The blending amount is 0.2 to 5.0% by mass, preferably 0.3 to 3% by mass, and more preferably 0.3 to 1% by mass. If the blending amount is less than 0.2% by mass, good quality foam cannot be obtained, and if it exceeds 5% by mass, the oral tissue is strongly stimulated and the flavor is impaired.
このうち、アルキル硫酸系界面活性剤としては、炭素数8〜18のアルキル基を有する硫酸およびその塩で、その塩がナトリウム、カリウム等のアルカリ金属塩またはトリエタノールアミンの塩のものが選ばれる。
具体的には、ラウリル硫酸ナトリウム、ラウリル硫酸カリウム、ラウリル硫酸トリエタノールアミン、ラウリル硫酸アンモニウム、オクチル硫酸ナトリウム、デシル硫酸ナトリウム、ミリスチル硫酸ナトリウム、セチル硫酸ナトリウムなどが挙げられる。
その中でも、デシル硫酸ナトリウム、デシル硫酸カリウム、ラウリル硫酸ナトリウム、ラウリル硫酸カリウムが特に好ましい。これらのアルキル硫酸塩化合物の場合アルキル鎖長に分布を持つものを用いてもよい。
Among them, as the alkylsulfuric surfactant, sulfuric acid having an alkyl group having 8 to 18 carbon atoms and a salt thereof, the salt of which is an alkali metal salt such as sodium or potassium or a salt of triethanolamine is selected. .
Specific examples include sodium lauryl sulfate, potassium lauryl sulfate, triethanolamine lauryl sulfate, ammonium lauryl sulfate, sodium octyl sulfate, sodium decyl sulfate, sodium myristyl sulfate, and sodium cetyl sulfate.
Among these, sodium decyl sulfate, potassium decyl sulfate, sodium lauryl sulfate, and potassium lauryl sulfate are particularly preferable. In the case of these alkyl sulfate compounds, those having a distribution in the alkyl chain length may be used.
アミノ酸系界面活性剤としては、炭素数8〜18の飽和または不飽和のアシル基を有するアミノ酸およびその塩で、塩がナトリウム、カリウム等のアルカリ金属塩またはトリエタノールアミン塩であるものが選ばれる。
具体的には、ヤシ油脂肪酸グリシンカリウムなどのN−アシルグリシンおよびその塩、オクタノイルサルコシンナトリウム、デカノイルサルコシンナトリウム、ラウロイルサルコシンナトリウム、ミリストイルサルコシントリエタノールアミンなどのアシルサルコシンおよびその塩、
N−オクタノイル−N−メチル−β−アラニンナトリウム、N−デカノイル−N−メチル−β−アラニンナトリウム、N−ラウロイル−N−メチル−β−アラニンナトリウム、N−パルミトイル−N−メチル−β−アラニンナトリウムなどのN−アシル−N−メチル−β−アラニンおよびその塩;N−オクタノイル−N−メチルタウリンナトリウム、N−デカノイル−N−メチルタウリンナトリウム、N−ラウロイル−N−メチルタウリンナトリウム、N−パルミトイル−N−メチルタウリンなどのN−アシル−N−メチルタウリンおよびその塩;N−オクタノイル−L−グルタミン酸ナトリウム、N−デカノイル−L−グルタミン酸ナトリウム、N−ラウロイル−L−グルタミン酸ナトリウム、N−ミリストイル−L−グルタミン酸ナトリウム、N−ココイル−L−グルタミン酸カリウム、N−ラウロイル−L−グルタミン酸トリエタノールなどのN−アシル−L−グルタミン酸およびその塩などが挙げられ、
N−アシルグリシンおよびその塩、N−アシルサルコシンおよびその塩、およびN−アシル−N−メチル−β−アラニンおよびその塩が好ましく、中でも、ヤシ油脂肪酸グリシンカリウムなどのN−アシルグリシンおよびその塩が特に好ましい。またアルキル鎖長に分布を持つものを用いてもよい。これらアニオン界面活性剤は、単独でまたは2種以上を組み合せて配合することができる。
As the amino acid surfactant, an amino acid having a saturated or unsaturated acyl group having 8 to 18 carbon atoms and a salt thereof, wherein the salt is an alkali metal salt such as sodium or potassium, or a triethanolamine salt is selected. .
Specifically, N-acyl glycine and its salts such as coconut oil fatty acid glycine potassium, acyl sarcosine and its salts such as octanoyl sarcosine sodium, decanoyl sarcosine sodium, lauroyl sarcosine sodium, myristoyl sarcosine triethanolamine,
N-octanoyl-N-methyl-β-alanine sodium, N-decanoyl-N-methyl-β-alanine sodium, N-lauroyl-N-methyl-β-alanine sodium, N-palmitoyl-N-methyl-β-alanine N-acyl-N-methyl-β-alanine and its salts such as sodium; N-octanoyl-N-methyltaurine sodium, N-decanoyl-N-methyltaurine sodium, N-lauroyl-N-methyltaurine sodium, N- N-acyl-N-methyltaurine and its salts such as palmitoyl-N-methyltaurine; N-octanoyl-L-glutamate sodium, N-decanoyl-L-glutamate sodium, N-lauroyl-L-glutamate sodium, N-myristoyl -Sodium L-glutamate N-acyl-L-glutamic acid such as potassium N-cocoyl-L-glutamate, triethanol N-lauroyl-L-glutamate, and salts thereof, and the like.
N-acylglycine and its salt, N-acyl sarcosine and its salt, and N-acyl-N-methyl-β-alanine and its salt are preferred, among them N-acylglycine and its salt such as coconut oil fatty acid glycine potassium Is particularly preferred. Moreover, you may use what has distribution in an alkyl chain length. These anionic surfactants can be blended alone or in combination of two or more.
更には、上記記載のアニオン界面活性剤のうちアルキル基、アシル基の炭素数が8以上11以下の鎖長を有するアニオン界面活性剤が、液体組成物中に含まれるアニオン界面活性剤の全量のうちの10〜35%であることが好ましく、15〜25%であることが更に好ましい。さらにアニオン界面活性剤のアルキル基、アシル基の炭素数が10であることが更に好ましい。この場合、炭素数が特定の長さのアニオン界面活性剤を用いてもよいし、このような比率になるような炭素数の分布を持つアニオン界面活性剤を用いても良い。 Furthermore, among the anionic surfactants described above, an anionic surfactant having a chain length of 8 to 11 carbon atoms in the alkyl group and acyl group is the total amount of the anionic surfactant contained in the liquid composition. Of these, 10 to 35% is preferable, and 15 to 25% is more preferable. Furthermore, it is more preferable that the alkyl group and acyl group of the anionic surfactant have 10 carbon atoms. In this case, an anionic surfactant having a specific carbon number may be used, or an anionic surfactant having such a carbon number distribution as to have such a ratio may be used.
本発明の泡沫状フッ素塗布剤に用いる水酸基を持つ化合物は、特に限定されるものではないが、アルコール類、多価アルコール類、糖及び糖アルコール類、ポリオキシエチレン基を有する化合物、フェノール類が選ばれる。
用いる水酸基を持つ化合物としては、アルコール類、多価アルコール類、糖及び糖アルコール類、ポリオキシエチレン基を有する化合物類、フェノール類から選ばれ、例えば、エチルアルコール、イソプロピルアルコール等のアルコール類;グリセリン、エチレングリコール、プロピレングリコール、1、3-ブチレングリコール、ポリエチレングリコール、ポリプロピレングリコール、ポリブチレングリコール、ポリグリセリン等の多価アルコール類;ソルビトール、キシリトール、パラチノース、パラチニット、エリスリトール、トレハロース、ラクチトール糖及び糖アルコール類;ポリオキシエチレン硬化ひまし油、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンポリオキシプロピレン共重合体等のポリオキシエチレン基を有する化合物類;チモール、カルバクロール、3-メチル-4-イソプロピルフェノール、レゾルシノール、オイゲノール、イソオイゲノール、サリチル酸、サリチル酸エステル、ヒドロキシ安息香酸エステルのフェノール類が選ばれる。
これらのうち、好ましくは、エチルアルコール、グリセリン、プロピレングリコール、1、3-ブチレングリコール、ポリエチレングリコール、ポリプロピレングリコール、ソルビトール、キシリトール、パラチノース、パラチニット、エリスリトール、トレハロース、ポリオキシエチレンポリオキシプロピレン共重合体、ポリオキシエチレンソルビタン脂肪酸エステル、ヒドロキシ安息香酸エステルが選ばれ、更に好ましくは、エチルアルコール、グリセリン、プロピレングリコール、ポリエチレングリコール、ソルビトール、キシリトール、パラチノース、パラチニット、エリスリトール、トレハロース、ポリオキシエチレンポリオキシプロピレン共重合体、ポリオキシエチレンソルビタン脂肪酸エステル、ヒドロキシ安息香酸エステルが選ばれる。
これらは3種以上、好ましくは4種以上を組み合せて配合される。これら水酸基を含む化合物が2種以下の場合は、使用に耐えうる粘度、溶解性、使用感を有する液体組成物を調製することができない。
The compound having a hydroxyl group used in the foamy fluorine coating agent of the present invention is not particularly limited, but alcohols, polyhydric alcohols, sugars and sugar alcohols, compounds having a polyoxyethylene group, and phenols may be used. To be elected.
The compound having a hydroxyl group to be used is selected from alcohols, polyhydric alcohols, sugars and sugar alcohols, compounds having a polyoxyethylene group, and phenols, for example, alcohols such as ethyl alcohol and isopropyl alcohol; glycerin , Ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, polybutylene glycol, polyglycerin and other polyhydric alcohols; sorbitol, xylitol, palatinose, palatinit, erythritol, trehalose, lactitol sugar and sugar alcohol Polyoxyethylene such as polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene polyoxypropylene copolymer, etc. Compounds having a len group; thymol, carvacrol, 3-methyl-4-isopropylphenol, resorcinol, eugenol, isoeugenol, salicylic acid, salicylic acid ester, hydroxybenzoic acid phenols are selected.
Of these, ethyl alcohol, glycerin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, sorbitol, xylitol, palatinose, palatinit, erythritol, trehalose, polyoxyethylene polyoxypropylene copolymer, Polyoxyethylene sorbitan fatty acid ester and hydroxybenzoic acid ester are selected, and more preferably ethyl alcohol, glycerin, propylene glycol, polyethylene glycol, sorbitol, xylitol, palatinose, palatinit, erythritol, trehalose, polyoxyethylene polyoxypropylene copolymer Coalesced polyoxyethylene sorbitan fatty acid ester, hydroxybenzoic acid ester To be elected.
These are blended in combination of three or more, preferably four or more. When the number of these hydroxyl group-containing compounds is 2 or less, it is impossible to prepare a liquid composition having a viscosity, solubility and usability that can withstand use.
その配合量の合計は3〜17質量%であり、さらに好ましくは5〜15質量%である。配合量が3質量%に満たない場合でも、17質量%を超える場合でも、使用に耐えうる粘度、溶解性、使用感を有する液体組成物を調製することができない。 The total amount is 3 to 17% by mass, more preferably 5 to 15% by mass. Even when the blending amount is less than 3% by mass or exceeds 17% by mass, it is impossible to prepare a liquid composition having a viscosity, solubility and use feeling that can withstand use.
本発明の泡沫状フッ素塗布剤には、前記成分の他に、通常口腔用組成物に用いられる成分、例えば前記以外の界面活性剤、湿潤剤、一価アルコール、増粘剤、香料、甘味剤、pH調整剤、防腐剤、色素等を、本発明の効果を損なわない範囲で適宜配合することができる。しかし、本発明の泡沫状フッ素塗布剤は、多孔質膜を有するフォーマー容器に充填して用いるため、多孔質膜の目詰まりを引き起こすような研磨剤等水不溶性粉体は配合しない。 In addition to the above-mentioned components, the foamy fluorine coating agent of the present invention usually contains components used in oral compositions, for example, surfactants other than those described above, wetting agents, monohydric alcohols, thickeners, fragrances, sweeteners. , PH adjusters, preservatives, pigments and the like can be appropriately blended within a range not impairing the effects of the present invention. However, since the foamed fluorine coating agent of the present invention is used by filling a former container having a porous film, water-insoluble powders such as abrasives that cause clogging of the porous film are not blended.
前記以外の界面活性剤としては、カルボキシベタイン系、アミドベタイン系、スルホベタイン系などの両性界面活性剤;ポリオキシエチレン脂肪酸エステル系などの非イオン界面活性剤;第四級アンモニウム塩系、アミン塩系のカチオン界面活性剤などが挙げられ、これらは単独または2種以上を組み合わせて必要に応じて配合することができる。
口腔刺激を低く抑えるためには、界面活性剤の配合量は少ないことが好ましい。その場合、アニオン界面活性剤の配合量が0.2〜1質量%とすることができるが、非イオン界面活性剤を含まないようにすると、更に泡もちが良い製剤にすることができる。
Other surfactants include amphoteric surfactants such as carboxybetaine, amidebetaine, and sulfobetaine; nonionic surfactants such as polyoxyethylene fatty acid ester; quaternary ammonium salts, amine salts Examples thereof include cationic surfactants of the type, and these can be blended as needed alone or in combination of two or more.
In order to suppress oral irritation low, it is preferable that the amount of the surfactant is small. In this case, the anionic surfactant can be added in an amount of 0.2 to 1% by mass. However, if the nonionic surfactant is not included, a formulation with better foam can be obtained.
増粘剤としては、例えば、カラゲナン、カルボキシメチルセルロース等のセルロース誘導体、アルギン酸ナトリウム等のアルカリ金属アルギネート、キサンタンガム、トラガカントガム、アラビアガム等のガム類、ポリビニルアルコール、ポリアクリル酸ナトリウムなどの合成粘結剤、シリカゲル、アルミニウムシリカゲル、ビーガム等の無機粘結剤などが挙げられ、これらは、組成物の25℃における粘度が100cps以下となるよう、単独または2種以上を組み合わせて配合することができる。100cpsを超えると、組成物が多孔質膜を通過し難くなり、泡が吐出されない場合がある。これら増粘剤の配合量は、通常、組成物全量に対して0.01〜5質量%である。 Examples of thickeners include, for example, cellulose derivatives such as carrageenan and carboxymethylcellulose, alkali metal alginates such as sodium alginate, gums such as xanthan gum, tragacanth gum and gum arabic, synthetic binders such as polyvinyl alcohol and sodium polyacrylate, Examples thereof include inorganic binders such as silica gel, aluminum silica gel, and bee gum, and these can be blended alone or in combination of two or more thereof so that the viscosity of the composition at 25 ° C. is 100 cps or less. When it exceeds 100 cps, it becomes difficult for the composition to pass through the porous membrane, and bubbles may not be discharged. The compounding quantity of these thickeners is 0.01-5 mass% normally with respect to the composition whole quantity.
香味剤としては、例えば、メントール、カルボン、アネトール、オイゲノール、サリチル酸メチル、リモネン、オシメン、n−デシルアルコール、シトロネール、α−テルピネオール、メチルアセタート、シトロネニルアセタート、メチルオイゲノール、シネオール、リナロール、エチルリナロール、ワニリン、チモール、スペアミント油、ペパーミント油、レモン油、オレンジ油、セージ油、ローズマリー油、珪皮油、シソ油、冬緑油、丁子油、ユーカリ油などが挙げられ、これらは単独または2種以上を組み合わせて配合することができる。その配合量は、通常、組成物全量に対して0.05〜3質量%、好ましくは0.05〜1質量%である。 As a flavoring agent, for example, menthol, carvone, anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronell, α-terpineol, methyl acetate, citronenyl acetate, methyl eugenol, cineol, linalool, Examples include ethyl linalool, crocodile, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, perilla oil, winter green oil, clove oil, and eucalyptus oil. Or it can mix | blend in combination of 2 or more types. The compounding quantity is 0.05-3 mass% normally with respect to the composition whole quantity, Preferably it is 0.05-1 mass%.
さらに、甘味剤としては、例えば、サッカリンナトリウム、アセスルファームカリウム、ステビオサイド、ネオヘスペリジルジヒドロカルコン、グリチルリチン、ペリラルチン、タウマチン、アスパラチルフェニルアラニルメチルエステル、ρ−メトキシシンナミックアルデヒドなどが挙げられ、これらは単独または2種以上を組み合わせて配合することができる。その配合量は、通常、組成物全体に対して0.01〜1質量%、好ましくは0.05〜0.5質量%である。 Furthermore, examples of the sweetening agent include saccharin sodium, acesulfame potassium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perilartin, thaumatin, asparatylphenylalanyl methyl ester, ρ-methoxycinnamic aldehyde, and the like. Can be blended alone or in combination of two or more. The compounding quantity is 0.01-1 mass% normally with respect to the whole composition, Preferably it is 0.05-0.5 mass%.
本発明のフッ素塗布剤は、これらの成分を混合し、通常の方法に従って製造することができ、得られた組成物は多孔質膜を有するフォーマー容器に充填される。本発明のフッ素塗布剤を充填するフォーマー容器は、容器に加圧して組成物を空気と混合し、多孔質膜を通過させることにより、泡沫状として吐出するものであれば何れでもよい。例えば加圧する方法が、軟質容器の胴部を手指で押圧するタイプのスクイーズフォーマーや、ポンプ機構を備えたキャップの頭部を手指で押圧するタイプのポンプフォーマーなどが挙げられる。 The fluorine coating agent of the present invention can be produced by mixing these components and according to an ordinary method, and the obtained composition is filled in a former container having a porous film. The former container filled with the fluorine coating agent of the present invention may be any one as long as it is discharged as a foam by pressurizing the container, mixing the composition with air, and passing the porous film. For example, the method of pressurization includes a squeeze foamer that presses the body of the soft container with fingers, and a pump former that presses the head of a cap equipped with a pump mechanism with fingers.
さらに、本発明の泡沫状フッ素塗布剤は、通常のフッ化物ゲル等で使用される歯科用フッ素トレー等を用いた、トレー法に用いることができる。例えば「本泡沫状フッ素塗布剤を前述のようにフォーマー容器から泡沫状として、歯科用フッ素トレーに適量吐出させる。そしてそのトレーを塗布させる人の口腔内に挿入し、トレーと歯牙とを重ねあわせ、1分から5分程度、軽く噛ます。」という使用方法が考えられる。 Furthermore, the foamy fluorine coating agent of the present invention can be used in a tray method using a dental fluorine tray or the like used in a normal fluoride gel or the like. For example, “This foamy fluorine coating agent is foamed from the former container as described above and is discharged into a dental fluorine tray. Then, the tray is inserted into the oral cavity of the person to be coated, and the tray and teeth are overlapped. It is conceivable to use it lightly for about 1 to 5 minutes.
長時間低温の環境に放置、貯蔵しておいても白濁や沈殿を生じない性状安定性の良い泡沫状フッ素塗布剤を得るために液体組成物中のナトリウムイオンの量を2質量%以下にすることが更に好ましい。内容物全体のナトリウムイオンは、組成物を調製する際、種々のpH調整剤や界面活性剤、粘稠剤等の原料から供給される。通常、このような組成物においてナトリウムを無配合することは困難である。本発明は、泡沫状の組成物を構成する際に、使用する原料を選択することにより、全体として配合されるナトリウムイオンの量を2質量%以下にする。 The amount of sodium ions in the liquid composition is 2% by mass or less in order to obtain a foamy fluorine coating agent having good property stability that does not cause white turbidity or precipitation even when stored and stored in a low temperature environment for a long time. More preferably. Sodium ions in the entire contents are supplied from raw materials such as various pH adjusters, surfactants and thickeners when preparing the composition. Usually, it is difficult to add no sodium in such a composition. This invention makes the quantity of the sodium ion mix | blended as a whole or less by selecting the raw material to be used when comprising a foam-like composition.
つぎに、試験例および実施例を挙げて本発明をさらに詳しく説明するが、本発明はこれらに限定されるものではない。実施例中の配合量はいずれも質量%を意味する。 Next, the present invention will be described in more detail with reference to test examples and examples, but the present invention is not limited thereto. All the compounding quantities in an Example mean the mass%.
試験例1:水酸基を有する化合物による低温安定性、性状、泡もち評価
下記成分と表1に示す実施例1〜9及び比較例1〜4の各成分から液体組成物を常法により調製し、下記の評価基準を用いて、低温安定性については調製後5℃で1ヶ月放置後のものについて、性状については調製後直ぐに評価をおこなった。泡もちについては、調製後直ぐと、常温に1ヶ月放置した後とに、組成物をフォーマー容器に充填し泡末状にして、100mlのグラスに吐出し、吐出後直ぐから5分後の嵩高さの減少量を評価した。結果を表1下段に示す。
成分 配合量(質量%)
フッ化ナトリウム 2.0
リン酸 0.02
リン酸水素ナトリウム 0.2
水酸基を有する化合物 表1
ラウリル硫酸ナトリウム 表1
甘味剤 0.2
香料 0.1
残部 精製水
合計 100.0
調製された泡沫状フッ素塗布剤を、性状、泡もち及び低温安定性を評価した。
低温安定性 ○: 沈殿が認められなかった
×: 沈殿が認められた
性状 ○: 製剤調製後、透明均一な液体
×: 製剤調製後、不透明または不均一な液体
泡もち ○: 嵩の減少率が80%以上100%
△: 嵩の減少率が60%以上80%未満
×: 嵩の減少率が60%未満
総合評価 ○: 低温安定性、性状、泡もちの全ての評価が○であったもの
△: 低温安定性、性状の評価が○で、泡もちの評価に△のあるもの
×: 各評価において1つでも×があったもの
総合評価で△以上である、低温安定性、性状に合格し泡もちが△以上の評価のものを合格とした。
Test Example 1: Low-temperature stability, properties, and foaminess evaluation by a compound having a hydroxyl group A liquid composition was prepared from the following components and the components of Examples 1 to 9 and Comparative Examples 1 to 4 shown in Table 1 by a conventional method. Using the following evaluation criteria, the low-temperature stability was evaluated after 5 months at 5 ° C. and left for 1 month, and the properties were evaluated immediately after the preparation. As for the foam, immediately after preparation, after leaving it to stand at room temperature for 1 month, the composition is filled into a foam container, foamed into a foam, discharged into a 100 ml glass, and bulky 5 minutes after discharge. The amount of decrease was evaluated. The results are shown in the lower part of Table 1.
Ingredient Amount (% by mass)
Sodium fluoride 2.0
Phosphoric acid 0.02
Sodium hydrogen phosphate 0.2
Compounds having a hydroxyl group Table 1
Sodium lauryl sulfate Table 1
Sweetener 0.2
Fragrance 0.1
Balance of purified water 100.0
The prepared foamy fluorine coating agent was evaluated for properties, foaminess and low-temperature stability.
Low temperature stability ○: No precipitation was observed
×: Precipitation observed ○: Transparent and uniform liquid after preparation
×: Opaque or non-uniform liquid foam after preparation preparation ○: Bulk reduction rate is 80% or more and 100%
Δ: Bulk reduction rate of 60% or more and less than 80%
X: Comprehensive evaluation with less than 60% reduction in bulk ○: Low-temperature stability, properties, and foam evaluation were all evaluated as ○
Δ: Evaluation of low-temperature stability and properties is ○, and evaluation of bubble stickiness is Δ
X: There was at least one x in each evaluation. A low evaluation in which the overall evaluation was Δ or higher, the low-temperature stability and the properties were passed, and the foam was evaluated as Δ or higher.
表1の結果より、実施例1〜9はすべて、低温において白濁・沈殿を生じることなく性状が安定していることがわかった。加えて性状、調製後及び常温1ヶ月後の評価における泡もちにおいても要求品質を満足していることが認められた。それに対して、比較例1〜4はすべて低温において白濁や沈殿が生じることが認められた。 From the results in Table 1, it was found that all of Examples 1 to 9 were stable in properties without causing cloudiness or precipitation at low temperatures. In addition, it was confirmed that the required quality was satisfied even in the case of the foam quality in the evaluation after the properties, preparation and one month at room temperature. On the other hand, in Comparative Examples 1 to 4, it was recognized that white turbidity and precipitation occurred at low temperatures.
試験例2:アニオン界面活性剤のアルキル基炭素数による低温安定性、性状、泡もち評価
下記成分と表2に示す実施例10〜14及び比較例5〜8の各成分から液体組成物を常法により調製し、試験例1と同様の評価を用いて評価を行なった。結果を表2下段に示す。
成分 配合量(質量%)
フッ化ナトリウム 2.0
リン酸 0.02
リン酸水素ナトリウム 0.2
エタノール 0.5
グリセリン 5.0
ポリエチレングリコール 1.0
パラオキシ安息香酸メチル 0.1
パラオキシ安息香酸ブチル 0.1
アルキル硫酸ナトリウム(アルキル基の炭素数の構成は表2) 0.5
甘味剤 0.2
香料 0.1
精製水 残部
合計 100.0
Test Example 2: Low-temperature stability, properties, and bubble proof evaluation based on the number of carbon atoms of the alkyl group of the anionic surfactant Prepared by the method and evaluated using the same evaluation as in Test Example 1. The results are shown in the lower part of Table 2.
Ingredient Amount (% by mass)
Sodium fluoride 2.0
Phosphoric acid 0.02
Sodium hydrogen phosphate 0.2
Ethanol 0.5
Glycerin 5.0
Polyethylene glycol 1.0
Methyl paraoxybenzoate 0.1
Butyl paraoxybenzoate 0.1
Sodium alkyl sulfate (the composition of the carbon number of the alkyl group is Table 2) 0.5
Sweetener 0.2
Fragrance 0.1
Purified water balance 100.0
表2の結果より、実施例10〜14はすべて、1ヶ月の低温放置後、白濁・沈殿を生じることなく性状が安定していることがわかる。それに対して、比較例5〜8は、低温において白濁や沈殿が生じるか、または泡もちにおいて著しい劣ることが認められた。 From the results of Table 2, it can be seen that all of Examples 10 to 14 have stable properties without being clouded or precipitated after being left at a low temperature for 1 month. On the other hand, in Comparative Examples 5 to 8, it was recognized that white turbidity and precipitation occurred at low temperatures, or that the foam was significantly inferior.
試験例3:アニオン界面活性剤の配合量による低温安定性、性状、泡もち、口腔内刺激、香味評価
下記成分と表3に示す実施例15〜20及び比較例9〜10の各成分から液体組成物を常法により調製し、低温安定性、性状、泡もちについては試験例1と同様の評価を用いて評価を行い、泡のきめ、口腔内刺激、香味立ち評価及び総合評価については下記の評価基準を用いて評価を行なった。結果を表3下段に示す。
成分 配合量(質量%)
フッ化ナトリウム 2.0
リン酸 0.02
リン酸水素ナトリウム 0.2
エタノール 0.5
グリセリン 5.0
ポリエチレングリコール 1.0
アルキル硫酸ナトリウム(実施例12) 表3
ポリオキシエチレンポリオキシプロピレン共重合体 表3
ポリオキシエチレンソルビタン脂肪酸エステル 表3
パラオキシ安息香酸メチル 0.1
パラオキシ安息香酸ブチル 0.1
甘味剤 0.2
香料 0.1
精製水 残部
合計 100.0
泡のきめ ○: 均一で細かい
△: 大きな泡がやや混じる
×: 大きな泡が非常に多い
口腔内刺激 ○: 口腔粘膜に異常がない
△: 口腔粘膜に変性が認められる
×: 口腔粘膜の剥離が認められる
香味立ち ○: 香味立ちが良好
△: 香味立ちがやや悪い
×: 香味立ちが非常に悪く、実使用に耐えない
総合評価 ○: 評価項目の全が○であったもの
△: 低温安定性、性状の評価が○で、泡もち、泡のきめ、口腔内刺
激及び香味立ちの評価に少なくとも1つ△のあるもの
×: 各評価において1つでも×があったもの
総合評価で△以上である、低温安定性、性状に合格し泡もち、泡のきめ、口腔内刺激及び香味立ちが△以上の評価のものを合格とした。
Test Example 3: Low temperature stability, properties, foaminess, oral irritation, flavor evaluation by blending amount of anionic surfactant Liquid from each component of Examples 15 to 20 and Comparative Examples 9 to 10 shown in Table 3 below The composition is prepared by a conventional method, and the low temperature stability, properties, and foam are evaluated using the same evaluation as in Test Example 1, and foam texture, oral stimulation, flavor evaluation and comprehensive evaluation are described below. Evaluation was performed using the following evaluation criteria. The results are shown in the lower part of Table 3.
Ingredient Amount (% by mass)
Sodium fluoride 2.0
Phosphoric acid 0.02
Sodium hydrogen phosphate 0.2
Ethanol 0.5
Glycerin 5.0
Polyethylene glycol 1.0
Sodium alkyl sulfate (Example 12) Table 3
Polyoxyethylene polyoxypropylene copolymers Table 3
Polyoxyethylene sorbitan fatty acid ester Table 3
Methyl paraoxybenzoate 0.1
Butyl paraoxybenzoate 0.1
Sweetener 0.2
Fragrance 0.1
Purified water balance 100.0
Bubble texture ○: Uniform and fine
Δ: Large bubbles slightly mixed
×: Oral irritation with a lot of large bubbles ○: No abnormality in oral mucosa
Δ: Degeneration is observed in oral mucosa
×: Flavor standing where peeling of oral mucosa is recognized ○: Flavor standing is good
Δ: Slightly bad flavor
×: Overall evaluation with very poor flavor and enduring actual use ○: All evaluation items were ○
Δ: Evaluation of low-temperature stability and properties is ○, foamy, foam texture, intraoral puncture
There is at least one △ in evaluation of intense and flavor standing
X: There was at least one x in each evaluation. Overall evaluation was △ or higher, low-temperature stability, properties passed, foamy, foam texture, oral irritation and flavor standing evaluated △ or higher. Passed.
表3の結果より、実施例15〜20はすべて、低温安定性、性状、泡もち、泡のきめ、口腔内刺激、香味立ちの評価において製品としての致命的な問題は認められなかった。それに対して、比較例9〜10においては、いくつかの評価項目において致命的な問題が認められた。 From the results of Table 3, in all of Examples 15 to 20, no fatal problems as products were recognized in the evaluation of low-temperature stability, properties, foaminess, foam texture, oral stimulation, and flavoring. On the other hand, in Comparative Examples 9 to 10, fatal problems were recognized in some evaluation items.
実施例22 下記の各成分から常法に従ってフッ素塗布剤を調製し、多孔質膜を有するポンプ式フォーマー容器に充填した。
成分 配合量(質量%)
フッ化ナトリウム 2.0
アルキル硫酸ナトリウム 0.4
(全アルキル硫酸ナトリウムにおけるC10アルキル硫酸ナトリウムの割合が17.5%
)
リン酸水素ナトリウム 0.2
リン酸 0.05
プロピレングリコール 1.5
濃グリセリン 5.0
ポリエチレングリコール 0.8
パラヒドロキシ安息香酸メチル 0.2
サッカリンナトリウム 0.1
香料 0.1
精製水 残部
合計 100.0
Example 22 A fluorine coating agent was prepared from the following components according to a conventional method, and filled into a pump-type former container having a porous membrane.
Ingredient Amount (% by mass)
Sodium fluoride 2.0
Sodium alkyl sulfate 0.4
(The proportion of C10 sodium alkyl sulfate in the total sodium alkyl sulfate is 17.5%
)
Sodium hydrogen phosphate 0.2
Phosphoric acid 0.05
Propylene glycol 1.5
Concentrated glycerin 5.0
Polyethylene glycol 0.8
Methyl parahydroxybenzoate 0.2
Saccharin sodium 0.1
Fragrance 0.1
Purified water balance 100.0
参考例23 下記の各成分から常法に従ってフッ素塗布剤を調製し、多孔質膜を有するポンプ式フォーマー容器に充填した。
成分 配合量(質量%)
フッ化ナトリウム 2.0
フッ化水素酸 0.3
ラウリル硫酸ナトリウム 1.0
(アルキル基に分布を持っているラウリル硫酸ナトリウムで、アルキル基のそれぞれの炭
素数ごとの割合が、全ラウリル硫酸ナトリウム配合量に対して、C8が3%、C10が1
7.5%、C12が70%、C14が12%)
スルホコハク酸ポリオキシエチレン(2モル)ラウリル二ナトリウム 1.0
ポリオキシエチレンポリオキシプロピレン共重合体 5.5
ヤシ油脂肪酸ジエタノールアミド 0.5
リン酸三カリウム三水和物 3.0
クエン酸三カリウム二水和物 1.0
香料 1.0
エタノール 2.5
ソルビット 10.0
サッカリンナトリウム 0.6
水 残部
合計 100.0
Reference Example 23 A fluorine coating agent was prepared from the following components according to a conventional method, and filled in a pump-type former container having a porous membrane.
Ingredient Amount (% by mass)
Sodium fluoride 2.0
Hydrofluoric acid 0.3
Sodium lauryl sulfate 1.0
(Sodium lauryl sulfate having a distribution in the alkyl group, the ratio of each carbon number of the alkyl group is 3% for C8 and 1 for C10 with respect to the total amount of sodium lauryl sulfate.
7.5%, C12 is 70%, C14 is 12%)
Polyoxyethylene sulfosuccinate (2 mol) disodium lauryl 1.0
Polyoxyethylene polyoxypropylene copolymer 5.5
Palm oil fatty acid diethanolamide 0.5
Tripotassium phosphate trihydrate 3.0
Tripotassium citrate dihydrate 1.0
Fragrance 1.0
Ethanol 2.5
Sorbit 10.0
Saccharin sodium 0.6
Water balance 100.0
参考例24 下記の各成分から常法に従ってフッ素塗布剤を調製し、多孔質膜を有するポンプ式フォーマー容器に充填した。
成分 配合量(質量%)
フッ化ナトリウム 2.0
リン酸 0.03
リン酸水素二カリウム 0.18
ラウリル硫酸ナトリウム 2.0
(アルキル基に分布を持っているラウリル硫酸ナトリウムで、アルキル基のそれぞれの炭
素数ごとの割合が、全ラウリル硫酸ナトリウム配合量に対して、C10が17.5%、C
12が70%、C14が12.5%)
ポリオキシエチレンポリオキシプロピレン共重合体 5.0
ポリオキシエチレンソルビタン脂肪酸エステル 1.0
グリセリン 5.0
サッカリンナトリウム 0.2
香料 1.0
水 残部
合計 100.0
Reference Example 24 A fluorine coating agent was prepared from the following components according to a conventional method, and filled in a pump-type former container having a porous membrane.
Ingredient Amount (% by mass)
Sodium fluoride 2.0
Phosphoric acid 0.03
Dipotassium hydrogen phosphate 0.18
Sodium lauryl sulfate 2.0
(Sodium lauryl sulfate having a distribution in the alkyl group, and the proportion of each carbon number of the alkyl group is 17.5% C10 with respect to the total amount of sodium lauryl sulfate, C
12 is 70%, C14 is 12.5%)
Polyoxyethylene polyoxypropylene copolymer 5.0
Polyoxyethylene sorbitan fatty acid ester 1.0
Glycerin 5.0
Saccharin sodium 0.2
Fragrance 1.0
Water balance 100.0
上記記載の実施例22は5℃に1ヶ月放置後も白濁や沈殿を生じることなく、性状が安定しており、調製後も常温放置1ヶ月後も良好な泡もちであり、泡のきめ、口腔内刺激、香味立ちなどがよく、良好な使用感であった。 Example 22 described above is stable in properties without causing cloudiness or precipitation even after being left at 5 ° C. for 1 month, and has a good foam after preparation and at room temperature for 1 month. The mouth irritation and flavoring were good and the feeling was good.
Claims (3)
(A)フッ化物イオンを0.5〜2質量%供給するフッ化物(A) Fluoride supplying 0.5-2% by mass of fluoride ion
(B)リン酸イオン0.01〜10質量%(B) Phosphate ion 0.01 to 10% by mass
(C)構成するアルキル基の炭素数分布において、炭素数8および10のアルキル基の合計の存在比が構成する全体のアルキル基に対して9〜28質量%であることを特徴とするアルキル硫酸ナトリウム0.2〜5.0質量%(C) In the carbon number distribution of the constituting alkyl groups, the total abundance ratio of the alkyl groups having 8 and 10 carbon atoms is 9 to 28% by mass with respect to the total constituting alkyl groups. Sodium 0.2-5.0% by mass
(D)エチルアルコール、グリセリン、プロピレングリコール、ポリエチレングリコール、ソルビトール、ヒドロキシ安息香酸エステルからなる水酸基を有する化合物群から選ばれる3種以上(D) 3 or more types selected from the group of compounds having a hydroxyl group consisting of ethyl alcohol, glycerin, propylene glycol, polyethylene glycol, sorbitol, and hydroxybenzoic acid ester
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005329515A JP4996845B2 (en) | 2005-11-14 | 2005-11-14 | Foam-type fluorine coating agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005329515A JP4996845B2 (en) | 2005-11-14 | 2005-11-14 | Foam-type fluorine coating agent |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007137773A JP2007137773A (en) | 2007-06-07 |
JP4996845B2 true JP4996845B2 (en) | 2012-08-08 |
Family
ID=38201089
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005329515A Active JP4996845B2 (en) | 2005-11-14 | 2005-11-14 | Foam-type fluorine coating agent |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP4996845B2 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8802060B2 (en) | 2007-10-01 | 2014-08-12 | Colgate-Palmolive Company | Foamable fluoride oral care composition |
TWI687232B (en) * | 2014-12-26 | 2020-03-11 | 日商花王股份有限公司 | Liquid oral composition in bubble spray container |
TWI740832B (en) * | 2015-12-14 | 2021-10-01 | 日商花王股份有限公司 | Liquid oral composition in bubble spray container |
JP2020097557A (en) * | 2018-12-19 | 2020-06-25 | サンスター株式会社 | Oral composition |
CN110859765A (en) * | 2019-12-17 | 2020-03-06 | 北京天一恒康医疗器械有限公司 | Fluorinated foam for preventing dental caries |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3618205B2 (en) * | 1997-10-09 | 2005-02-09 | サンスター株式会社 | Foam-type fluorine coating agent |
-
2005
- 2005-11-14 JP JP2005329515A patent/JP4996845B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2007137773A (en) | 2007-06-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR20070090146A (en) | Two-component dental whitening compositions | |
AU2017240683B2 (en) | Oral care compositions containing potassium nitrate and peroxide | |
JP4996845B2 (en) | Foam-type fluorine coating agent | |
JP2016102076A (en) | Oral composition | |
JP5233399B2 (en) | Oral spray composition and oral preparation | |
JPH10251131A (en) | Composition for oral cavity | |
AU2017240033A1 (en) | Oral care compositions containing a gel network phase and potassium nitrate | |
AU2017240032B2 (en) | Oral care compositions containing gel networks and potassium nitrate | |
JP3618205B2 (en) | Foam-type fluorine coating agent | |
JP2012140333A (en) | Liquid composition for oral cavity | |
JPH08333226A (en) | Foamy composition for oral cavity | |
JPH10114636A (en) | Non-aerosol type foam oral cavity composition | |
JP5845603B2 (en) | Liquid or liquid oral composition and tongue coating adhesion inhibitor | |
JP7347916B2 (en) | dentifrice composition | |
JPH0672833A (en) | Production of dentifrice | |
JP2797716B2 (en) | Liquid dentifrice composition | |
JP2002193775A (en) | Set for tooth bleaching | |
JPH10139643A (en) | Oral cavity composition | |
WO2018062492A1 (en) | Aerosol for interdental cleaning | |
JP5393313B2 (en) | Oral composition | |
JP7000823B2 (en) | Toothpaste composition | |
JP6394360B2 (en) | Self-foaming dentifrice | |
JPH0745392B2 (en) | Toothpaste composition | |
WO2022054959A1 (en) | Composition for oral cavity | |
JP2019199467A (en) | Denture base composition and denture base fitting method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20081112 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120110 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120312 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20120508 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120514 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20150518 Year of fee payment: 3 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 Ref document number: 4996845 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |