JPH08333226A - Foamy composition for oral cavity - Google Patents

Abstract

PURPOSE: To obtain a nonaerosol type foamy composition for the oral cavity, filled in a nongas atmospheric-pressure container, foamable in use, applicable to brushing, excellent in dispersibility in the oral cavity and containing no polishing agent blended therein. CONSTITUTION: This foamy composition for the oral cavity contains >=0.2wt.% anionic surfactant (e.g. sodium laurylsulfate), 0.1-5wt.% nonionic surfactant (e.g. an alkyl fatty acid diethanolamide) or amphoteric surfactant (e.g. an alkylbetaine) and a viscous agent (e.g. a polyhydric alcohol) and/or a binder (e.g. hydroxyethyl cellulose) and further, as necessary, a perfume, a sweetener, a coloring matter, a preservative, a pharmacodynamically effective agent, ethanol, etc., blended therewith. At this time, the viscosity at 25 deg.C is kept at <=7P, preferably 0.05-1P and the composition for the oral cavity is filled in a nonaerosol type nongas atmospheric-pressure container for applying a pressure to the contents, mixing the contents with air and jetting the contents into a foamy shape by jetting thereof to afford the objective material.

Description

Detailed Description of the Invention

[0001]

INDUSTRIAL APPLICABILITY The present invention is designed so that a liquid oral composition having a viscosity at 25 ° C. of 7 poise or less is filled in a non-aerosol type non-gas atmospheric pressure container, and is sprayed and applied in a foam state when used. It relates to a foamy oral composition.

[0002]

2. Description of the Related Art Oral compositions such as dentifrices effectively exert the effects of medicinal ingredients for cleansing the inside of the mouth and, when they are mixed with medicinal ingredients. Therefore, it is important that the oral composition is easily spread to every corner of the oral cavity, and therefore a formulation having high dispersibility is desired.

Oral compositions are usually prepared in the form of liquids, pastes, etc. Among them, liquid dentifrices are known as highly dispersible preparations. However, the liquid dentifrice has a problem in usability because it is brushed while the liquid is contained in the mouth or after being discharged, and since it contains almost no foaming component or has low foaming property, it has a lubricating effect during brushing. There is not, and the usability is not good.

On the other hand, a toothpaste disperses the preparation in the oral cavity by mixing with saliva by brushing, so that the dispersibility is poorer than that of the liquid dosage form, and foaming becomes stronger over time, making it difficult to brush for a long time. There is a problem.

From these points, some techniques have been proposed in which a liquid dentifrice is blended with a foaming agent and foamed at the time of use to brush in a foamy form. For example, a method of encapsulating a formulation system containing a surfactant, water, a viscous agent, etc. in a pressure resistant container together with carbon dioxide gas, air, etc. to form a mousse-like foam (JP-A-63-233908) or There is known a method (Japanese Patent Laid-Open No. 3-77814) in which an inert gas and a mouthwash are pressurized and filled in a pressure-proof light-shielding container, and mousse-like bubbles are ejected during use.

[0006] However, these proposals enclose the liquid dentifrice in the pressure resistant container as described above, and have a problem in terms of safety in use and disposal in terms of environment.

The toothpaste and the dentifrice obtained by aerosolizing the toothpaste are mainly suitable for physical cleaning with an abrasive, and therefore may not be suitable for patients with root surface exposure or periodontal disease.

The present invention has been made in view of the above circumstances, and it is filled in a non-gas type atmospheric pressure container and can be foamed to be used for brushing at the time of use. It is intended to provide a composition for oral cavity.

[0009]

Means and Actions for Solving the Problems The inventors of the present invention have conducted extensive studies to achieve the above object, and as a result, have found that an anionic surfactant and a nonionic surfactant are contained in a liquid oral composition containing no abrasive. Used when it is filled in a non-aerosol type non-gas atmospheric pressure container by blending an agent or an amphoteric surfactant with a thickening agent and / or a binding agent and setting the viscosity to 7 poise or less at 25 ° C. It has been found that it is suitable for application by spraying and brushing in a good foamy state at times, and has excellent oral dispersibility.

That is, even if a conventional non-foaming liquid dentifrice or a dentifrice of the type which is filled under pressure with gas in the above conventional pressure resistant container is simply filled in a non-aerosol type non-gas atmospheric pressure container, It does not foam well at the time of its use, and therefore, the present inventor did not include an abrasive, and when used by filling the non-gas atmospheric pressure container, as a result of examining an oral composition that foams well, As described above, the anionic surfactant and the nonionic surfactant or the amphoteric surfactant and the thickening agent and / or the binder are blended, and particularly, the anionic surfactant is used as the surfactant in 0% of the entire composition. 2% (weight%, the same applies below) and a thickening agent and / or a binding agent so that the binding agent is 25% or less of the entire composition and the binding agent is 2% or less. Moreover, the viscosity at 25 ° C should be 7 poises or less. , In particular by 0.05 to 1 poise, it is when a good foam filled using the above non-gas atmospheric vessel, easy to use placed on a toothbrush,
By providing an excellent feeling of use due to the lubricating action of the foam, it is easy to brush for a long time because an appropriate amount of foam lasts, and moreover, it is easily dispersed in every corner of the mouth, and by incorporating a medicinal component into the composition. It has been found that the medicinal component can be spread to every corner of the oral cavity in a short time.

Accordingly, the present invention provides that the anionic surfactant is 0.2% or more of the total composition, the nonionic or amphoteric surfactant is 0.1 to 5%, and the thickener and / or Contains a binder and has a viscosity of 7 at 25 ° C without an abrasive.
Poise or less liquid oral composition, filled in a non-aerosol type non-gas atmospheric pressure container that mixes the content with air by applying a pressing force to the content and ejects it in a foam form from its ejection port A foamy composition for oral cavity is provided.

The present invention will be described in more detail below. The foamy oral composition of the present invention basically comprises a surfactant and a thickener and / or a binder in water, and if necessary, a flavor and a sweetener. A liquid oral composition is prepared by mixing agents, dyes, preservatives, medicinal ingredients, ethanol, etc., and filled in a non-gas atmospheric pressure container. It can be foamed and used by brushing. However, no abrasive was added. Further, in this case, by selecting the blending amount of the above components, the viscosity at 25 ° C. is 7 poise or less,
It is preferably 0.05 to 1 poise.

The surfactants used in the present invention include, as anionic surfactants, alkyl sulfates, alkyl ether sulfates, alkylbenzene sulfonates, N-acyl amino acid salts, N-acyl methyl taurine salts, alkyls. Ether acetate, sorbitan fatty acid ester as nonionic surfactant, glycerin fatty acid ester, sucrose fatty acid ester, polyoxyethylene fatty acid ester, polyoxyethylene / polyoxypropylene polymer, fatty acid diethanolamide, etc., alkyl as amphoteric surfactant Betaine, imidazolidinium betaine, lecithin and the like, cationic surfactants such as alkylammonium salts and alkylbenzylammonium salts, and further amino acid surfactants and the like can be mentioned. The combination of surfactant and a non-ionic surfactant or amphoteric surfactant is essential in view of foaming.

The content of the anionic surfactant is 0.2% or more of the total composition, preferably 0.2 to 3%, particularly preferably 0.2 to 2%, and the nonionic surfactant. The agent is 0.1-5%, especially 1-4%. The total amount of surfactants including anionic surfactants is 0.2 to 10
%, Particularly preferably 1 to 5%. If the compounding amount of the anionic surfactant is less than 0.2%, the foamability is poor.
Alkyl sulfate is preferable as the anionic surfactant, and 0.1% or more of alkyl fatty acid diethanolamide which is a nonionic surfactant, alkyl betaine which is an amphoteric surfactant, and imidazolinium betaine are added. This significantly improves the shape retention of the foam. The compounding amount of these activators is preferably 0.1 to 5% as described above. If it exceeds 5%, mucous membrane irritation becomes strong, and in the case of an amphoteric surfactant, separation and precipitation may occur.

Examples of the thickener include polyhydric alcohols such as glycerin, propylene glycol, polyethylene glycol and butylene glycol. The compounding amount thereof is preferably 0 to 25%, and particularly preferably 0 to 15% of the whole composition. If it is more than 25%, warmth, bitterness, stickiness, etc. may occur and the usability may deteriorate.

As the binder, hydroxyethyl cellulose, polyvinyl alcohol, sodium carboxymethyl cellulose, xanthan gum, carrageenan, gelatin, polyvinyl pyrrolidone, methyl cellulose, polyacrylate, alginate, carboxyvinyl polymer, locust bean gum, guar gum, Examples include gum arabic and the like. The compounding amount is 0 of the whole composition.
It is preferable to be ˜2%, especially 0-1%. If it is more than 2%, the viscosity increases and the extrusion from the container becomes poor, so that a cohesive foam does not form. In addition, it tends to be sticky during use and the feeling of use deteriorates.

The amounts of the thickening agent and the binding agent are not 0% at the same time. If neither the thickening agent nor the binding agent is added, the foam formed will be immediately broken. I will end up. Here, when only the thickening agent is added, the lower limit of the compounding amount is 3%, and when only the binder is added, the lower limit of the compounding amount is 0.1%. If both are used together, the lower limit of viscosity is 1
%, The lower limit of the binder is 0.05%.

Further, as a medicinal component, fluoride (sodium fluoride, sodium monofluorophosphate, stannous fluoride, etc.), enzyme agent (dextranase, mutanase, etc.), anti-inflammatory agent (dipotassium glycyrrhizinate) , Sodium azulensulphonate, allantoin, glycyrrhetinic acid, tranexamic acid), fungicides (triclosan, cetylpyridinium chloride, chlorhexidine salts, benzethonium chloride, benzalkonium chloride, biozole, thymol, etc.), deodorant components (copper chlorophin sodium, Copper gluconate etc.) and vitamin E etc. can be mentioned.
The blending amount can be an effective amount.

As the fragrance and other ingredients, known ingredients used in oral compositions can be used.

The present invention is to prepare a liquid form using the above components. In this case, the viscosity of the liquid oral composition at 25 ° C. is 7 poise or less, particularly 0.05 to 1 poise. is necessary. If the viscosity is higher than 7 poise, the foam formation is not performed well, and if the viscosity is too low, the shape retention of the foam is deteriorated.

In the present invention, the above liquid oral composition is a non-aerosol type non-gas normal agent in which the contents are mixed with air by applying a pressing force to the contents and ejected in a foam form from the ejection port. It is filled in a pressure vessel and foamed at the time of use.

Here, as such a container, a known squeeze type or dispenser type container can be used. For example, Japanese Utility Model Publication No. 7-6108 and Japanese Utility Model Publication No. 7-825.
1, those described in Japanese Utility Model Publication No. 4-102666 can be used, and specifically, various commercially available products can be used.

[0023]

EXAMPLES The present invention will be specifically described below by showing experimental examples and examples, but the present invention is not limited to the following examples. In the following examples,% means% by weight.

[Experimental Example 1] Effect of formulation viscosity on foam formation An oral composition having the formulation shown in Table 1 was prepared, and the viscosity at 25 ° C was measured with a B type viscosity type. Next, each composition for oral cavity was used as a non-gas atmospheric pressure container.
The container described in Japanese Patent No. 2666 (Jpn. Pat. Appln. KOKAI Publication No. 6-47577) was used to fill the container, and the composition for oral cavity was jetted in the form of foam. The state of foam formation was evaluated according to the criteria shown below. The results are shown in Table 1. Evaluation criteria for foam formation ◯: Foam is easily formed △: Slightly hard to extrude and hard to form a solid foam ×: Hard to extrude, not a solid foam

[0025]

[Table 1]

From the above results, when the viscosity of the formulated oral composition is 8 poises or more, it becomes difficult to form bubbles as the viscosity increases, and the oral composition having a viscosity characteristic of more than 10 poise is collected. It will be appreciated that it will be impossible to form bubbles.

[Experimental Example 2] Effect of Activator on Foam Formation Next, an oral composition having the formulation shown in Table 2 was prepared and placed in the same container as in Experimental Example 1, and the activator foamed. Was investigated. Sodium lauryl sulphate (anionic surfactant) and polyoxyethylene hydrogenated castor oil (nonionic surfactant) were used in combination as an activator and examined according to the evaluation criteria shown in Experimental Example 1.

[0028]

[Table 2]

From the above experimental results, with 0.1% of sodium lauryl sulfate (anionic surfactant), even if the foamability is increased by adding another active agent, the binder is increased to improve the shape retention. Although foam formation is not improved even if it is increased, good foam formation was achieved by adding 0.2% or more of an anionic surfactant.

[Experimental Example 3] An oral composition having the formulation shown in Table 3 was prepared and sprayed from the same container as in Experimental Example 1 onto a toothbrush, and the time until bubbles disappeared was measured. The result is shown in Figure 1.
Shown in

[0031]

[Table 3]

Myristic acid diethanolamide was added to 0.2
%, The foam shape-retaining property is improved, and the foam shape-retaining property is remarkably improved by simultaneously adding a thickening agent (glycerin or the like).

Examples will be shown below. Each of the oral compositions of the following examples was filled in the same container as in Experimental Example 1.

[Example 1] Sodium lauryl sulfate 0.5% Polyoxyethylene hydrogenated castor oil 2.0 Myristic acid diethanolamide 0.5 Hydroxyethyl cellulose 0.1 Glycerin 10.0 Ethyl alcohol 5.0 Sodium fluoride 0. 2 Purified water Residual ─────────────────────────────────── Total 100.0%

Example 2 Sodium lauryl sulfate 0.5% Lauroyl sarcosine sodium 0.5 Polyoxyethylene sorbitan monolaurate 2.0 Carrageenan 0.2 Polyethylene glycol 5.0 Ethyl alcohol 10.0 Mutanase 0.1 Triclosan 0.1 Purified water Residual ─────────────────────────────────── Total 100.0%

[Example 3] Sodium lauryl sulfate 0.5% Polyoxyethylene hydrogenated castor oil 2.0 Myristic acid diethanolamide 0.5 Hydroxyethyl cellulose 0.2 Polyvinylpyrrolidone 0.3 Glycerin 10.0 Sodium fluoride 0.0. 2 Tranexamic acid 0.05 Purified water Residue ─────────────────────────────────── Total 100.0%

[Example 4] Sodium lauryl sulfate 0.4% N-lauroylmethyl taurine sodium 0.1 Polyoxyethylene hydrogenated castor oil 2.0 Myristic acid diethanolamide 1.0 Xanthan gum 0.05 Sodium alginate 0.03 Glycerin 7.0 1,3-butylene glycol 3.0 Sodium fluoride 0.05 Purified water Residue ────────────────────────────── ────── Total 100.0%

Example 5 Sodium lauryl sulfate 0.4% N-lauroylmethyl taurine sodium 0.1 Polyoxyethylene hydrogenated castor oil 1.5 Polyoxyethylin cetyl ether 0.5 Myristic acid diethanolamide 0.7 Hydroxy Ethyl cellulose 0.2 Glycerin 7.0 Propylene glycol 3.0 Sodium fluoride 0.05 Purified water Residual ───────────────────────────── ──────── Total 100.0%

Example 6 Sodium lauryl sulfate 0.5% Polyoxyethylene hydrogenated castor oil 1.5 Myristic acid diethanolamide 1.0 Glycerin 5.0 Propylene glycol 2.0 1,3-Butylene glycol 3.0 Fluorine Sodium chloride 0.05 Purified water Residual ──────────────────────────────────── Total 100.0%

[Example 7] Sodium lauryl sulfate 0.2% Polyoxyethylene hydrogenated castor oil 2.0 Myristic acid diethanolamide 1.0 Hydroxyethyl cellulose 0.2 Glycerin 10.0 Sodium fluoride 0.2 Triclosan 0.1 Purified water Residual ──────────────────────────────────── Total 100.0%

[Example 8] Sodium lauryl sulfate 1.5% Myristic acid diethanolamide 0.5 Hydroxyethyl cellulose 0.4 Glycerin 10.0 Ethyl alcohol 10.0 Sodium fluoride 0.2 Tranexamic acid 0.05 Purified water residue ──────────────────────────────────── Total 100.0%

[Example 9] Sodium lauryl sulfate 0.5% Lauryl dimethylamino amino acid betaine 1.0 Polyoxyethylene hydrogenated castor oil 2.0 Hydroxyethyl cellulose 0.6 Polyethylene glycol 5.0 Ethyl alcohol 5.0 Dextranase 0.1 Allantoin 0.2 Purified water Residue ─────────────────────────────────── Total 100.0%

[Example 10] Sodium lauryl sulfate 1.0% Lauryl dimethylamino amino acid betaine 0.5 Polyoxyethylene hydrogenated castor oil 2.0 Carboxymethyl cellulose sodium 0.2 Glycerin 10.0 Dextranase 0.1 Cetyl chloride Pyridinium 0.05 Purified water Residue ─────────────────────────────────── Total 100.0%

[Example 11] Sodium lauryl sulfate 1.5% Myristic acid diethanolamide 0.5 Polyoxyethylene sorbitan monolaurate 1.5 Hydroxyethyl cellulose 0.2 Polyethylene glycol 5.0 Ethyl alcohol 15.0 Sodium fluoride 0.2 Triclosan 0.1 Purified water Residue ──────────────────────────────────── Total 100.0 %

[Example 12] Sodium lauryl sulfate 1.5% Polyoxyethylene hydrogenated castor oil 3.0 Myristic acid diethanolamide 0.5 Polyoxyethylene sorbitan monolaurate 2.0 Glycerin 10.0 Ethyl alcohol 10.0 Sodium monofluorophosphate 0.7 Triclosan 0.1 Tranexamic acid 0.05 Purified water Residue ───────────────────────────── ─────── Total 100.0%

[Example 13] Sodium lauryl sulfate 1.5% Polyoxyethylene hydrogenated castor oil 2.0 Polyvinyl alcohol 0.2 Glycerin 10.0 Ethyl alcohol 10.0 Sodium fluoride 0.2 Chlorhexidine gluconate 0.01 Purified water Residual ──────────────────────────────────── Total 100.0%

[Example 14] Sodium lauryl sulfate 1.0% Lauroyl sarcosine sodium 0.2 Polyoxyethylene hydrogenated castor oil 2.0 Myristic acid diethanolamide 0.3 Polyvinyl alcohol 0.2 Glycerin 10.0 Ethyl alcohol 5. 0 Sodium monofluorophosphate 0.7 Sodium azulensulphonate 0.02 Purified water Residue ─────────────────────────────── ────── Total 100.0%

Example 15 Sodium lauryl sulfate 0.5% Lauroyl sarcosine sodium 0.2 Lauryl dimethylaminoacetic acid betaine 0.5 Polyoxyethylene hydrogenated castor oil 2.0 Myristic acid diethanolamide 0.3 Hydroxyethyl cellulose 0.2 Glycerin 10.0 Ethyl alcohol 5.0 Sodium fluoride 0.2 Dipotassium glycyrrhizinate 0.05 Purified water Residue ────────────────────────── ────────── Total 100.0%

[0049]

EFFECT OF THE INVENTION Since the foamy oral composition of the present invention uses a non-gas atmospheric pressure container, there is no problem in safety and environment at the time of use and disposal, and it is easy to disperse in the oral cavity. , Good foam formation and an appropriate amount of foam lasting, so it is easy to brush for a long time, and the medicinal ingredient can be easily spread to every corner of the oral cavity. The oral and chemical effects make it possible to efficiently prevent oral diseases, and the lubricating effect of bubbles during brushing provides a good feeling in use.

[Brief description of drawings]

FIG. 1 is a graph showing the relationship between the foam disappearance time and the amount of myristic acid diethanolamide added according to an experimental example of the present invention.

Claims (3)

[Claims] 1. An anionic surfactant is added to the composition as a whole.
2% by weight or more, 0.1 to 5% by weight of a nonionic surfactant or an amphoteric surfactant, and a viscous agent and / or a binder, and the viscosity at 25 ° C. without an abrasive is 7 Poise or less liquid oral composition, filled in a non-aerosol type non-gas atmospheric pressure container that mixes the content with air by applying a pressing force to the content and ejects it in a foam form from its ejection port A foamy oral composition comprising: 2. The foamy oral composition according to claim 1, wherein the anionic surfactant is sodium lauryl sulfate, the nonionic surfactant is alkyl fatty acid diethanolamide, and the amphoteric surfactant is alkyl betaine or imidazolinium betaine. . 3. The foamy oral composition according to claim 1, wherein the thickening agent is a polyhydric alcohol, and the binding agent is hydroxyethyl cellulose, xanthan gum, polyvinylpyrrolidone, polyvinyl alcohol, sodium carboxymethyl cellulose.