TW201718582A - 用於發炎、自體免疫及/或增生性疾病之治療之新穎化合物及其醫藥組合物 - Google Patents

用於發炎、自體免疫及/或增生性疾病之治療之新穎化合物及其醫藥組合物 Download PDF

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Publication number
TW201718582A
TW201718582A TW105133608A TW105133608A TW201718582A TW 201718582 A TW201718582 A TW 201718582A TW 105133608 A TW105133608 A TW 105133608A TW 105133608 A TW105133608 A TW 105133608A TW 201718582 A TW201718582 A TW 201718582A
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Taiwan
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compound
group
alkyl
independently selected
pharmaceutically acceptable
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TW105133608A
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English (en)
Chinese (zh)
Inventor
瑞吉納德 克里斯多夫 薩維爾 布萊斯
朱利安 喬治斯 皮亞爾-奧利維亞 道央
拉斐爾 珍 喬耶爾 傑納
艾內 瑪莉 強庫爾
菲迪克 吉爾柏 拉貝吉葉赫
金-麥可 樂法蘭斯
奧斯卡 瑪摩利堤
克里斯托 奇尼 馬瑞 米那
班奴瓦 安圖瓦內 舒密特
德 普拉斯 史蒂芬 艾蜜勒 凡
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葛萊伯格有限公司
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Application filed by 葛萊伯格有限公司 filed Critical 葛萊伯格有限公司
Publication of TW201718582A publication Critical patent/TW201718582A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW105133608A 2015-10-19 2016-10-18 用於發炎、自體免疫及/或增生性疾病之治療之新穎化合物及其醫藥組合物 TW201718582A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1518456.7A GB201518456D0 (en) 2015-10-19 2015-10-19 Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory, autoimmune and/or proliferative diseases

Publications (1)

Publication Number Publication Date
TW201718582A true TW201718582A (zh) 2017-06-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
TW105133608A TW201718582A (zh) 2015-10-19 2016-10-18 用於發炎、自體免疫及/或增生性疾病之治療之新穎化合物及其醫藥組合物

Country Status (18)

Country Link
US (1) US10508111B2 (enExample)
EP (1) EP3365341B1 (enExample)
JP (1) JP2018530617A (enExample)
KR (1) KR20180064528A (enExample)
CN (1) CN108137584A (enExample)
AR (1) AR106384A1 (enExample)
AU (1) AU2016343225A1 (enExample)
BR (1) BR112018007392A2 (enExample)
CA (1) CA3002255A1 (enExample)
CO (1) CO2018004765A2 (enExample)
GB (1) GB201518456D0 (enExample)
IL (1) IL258707A (enExample)
MX (1) MX2018004517A (enExample)
PH (1) PH12018500827A1 (enExample)
RU (1) RU2018117499A (enExample)
SG (1) SG11201803095UA (enExample)
TW (1) TW201718582A (enExample)
WO (1) WO2017067848A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
GB201702603D0 (en) * 2017-02-17 2017-04-05 Galápagos Nv Novel compositions and pharmaceutical compositions thereof for the treatment of inflammatory disorders
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
TWI721483B (zh) 2018-07-13 2021-03-11 美商基利科學股份有限公司 吡咯并[1,2-b]嗒𠯤衍生物
GB201904373D0 (en) * 2019-03-29 2019-05-15 Galapagos Nv Novel compounds and pharamaceutical compositions thereof for the treatment of inflammatory disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY28506A1 (es) * 2003-09-12 2005-04-29 Basf Ag 6-halógeno-(1,2,4)triazolo(1,5-a)pirimidinas para combatir plagas animales.
GB2432834A (en) * 2004-01-12 2007-06-06 Cytopia Res Pty Ltd Selective Kinase Inhibitors
CA2825028A1 (en) * 2011-02-09 2012-08-16 F. Hoffman-La Roche Ag Heterocyclic compounds as pi3 kinase inhibitors
RU2016110852A (ru) * 2013-09-27 2017-10-30 Нимбус Айрис, Инк. Ингибиторы irak и их применения
UY35935A (es) * 2014-01-03 2015-06-30 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Compuestos de nicotinamida sustituida con heteroarilo como inhibidores de quinasa y moduladores de irak-4

Also Published As

Publication number Publication date
GB201518456D0 (en) 2015-12-02
US20180305351A1 (en) 2018-10-25
PH12018500827A1 (en) 2018-10-29
CO2018004765A2 (es) 2018-07-19
WO2017067848A1 (en) 2017-04-27
KR20180064528A (ko) 2018-06-14
IL258707A (en) 2018-06-28
JP2018530617A (ja) 2018-10-18
CN108137584A (zh) 2018-06-08
US10508111B2 (en) 2019-12-17
BR112018007392A2 (pt) 2018-10-16
RU2018117499A3 (enExample) 2020-01-24
AR106384A1 (es) 2018-01-10
EP3365341B1 (en) 2020-05-13
AU2016343225A1 (en) 2018-05-10
CA3002255A1 (en) 2017-04-27
RU2018117499A (ru) 2019-11-21
SG11201803095UA (en) 2018-05-30
MX2018004517A (es) 2018-06-27
EP3365341A1 (en) 2018-08-29

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