CO2018004765A2 - Derivados de 6-[5-amino-6-(2-etoxietoxi)-imidazo[4,5-b]piridin-3-il]nicotinonitrilo y su uso como inhibidores de cinasas asociadas al receptor de interleucina-1 (irak) - Google Patents
Derivados de 6-[5-amino-6-(2-etoxietoxi)-imidazo[4,5-b]piridin-3-il]nicotinonitrilo y su uso como inhibidores de cinasas asociadas al receptor de interleucina-1 (irak)Info
- Publication number
- CO2018004765A2 CO2018004765A2 CONC2018/0004765A CO2018004765A CO2018004765A2 CO 2018004765 A2 CO2018004765 A2 CO 2018004765A2 CO 2018004765 A CO2018004765 A CO 2018004765A CO 2018004765 A2 CO2018004765 A2 CO 2018004765A2
- Authority
- CO
- Colombia
- Prior art keywords
- ethoxyethoxy
- imidazo
- pyridin
- amino
- nicotinonitrile
- Prior art date
Links
- WUQITSNWWRHLEP-UHFFFAOYSA-N 6-[5-amino-6-(2-ethoxyethoxy)imidazo[4,5-b]pyridin-3-yl]pyridine-3-carbonitrile Chemical class NC1=C(C=C2C(=N1)N(C=N2)C1=NC=C(C#N)C=C1)OCCOCC WUQITSNWWRHLEP-UHFFFAOYSA-N 0.000 title abstract 2
- 102000019223 Interleukin-1 receptor Human genes 0.000 title 1
- 108050006617 Interleukin-1 receptor Proteins 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1518456.7A GB201518456D0 (en) | 2015-10-19 | 2015-10-19 | Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory, autoimmune and/or proliferative diseases |
| PCT/EP2016/074662 WO2017067848A1 (en) | 2015-10-19 | 2016-10-14 | 6-[5-amino-6-(2-ethoxyethoxy)-imidazo[4,5-b]pyridin-3-yl]-nicotinonitrile derivatives and their use as irak inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2018004765A2 true CO2018004765A2 (es) | 2018-07-19 |
Family
ID=55131239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2018/0004765A CO2018004765A2 (es) | 2015-10-19 | 2018-05-03 | Derivados de 6-[5-amino-6-(2-etoxietoxi)-imidazo[4,5-b]piridin-3-il]nicotinonitrilo y su uso como inhibidores de cinasas asociadas al receptor de interleucina-1 (irak) |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US10508111B2 (enExample) |
| EP (1) | EP3365341B1 (enExample) |
| JP (1) | JP2018530617A (enExample) |
| KR (1) | KR20180064528A (enExample) |
| CN (1) | CN108137584A (enExample) |
| AR (1) | AR106384A1 (enExample) |
| AU (1) | AU2016343225A1 (enExample) |
| BR (1) | BR112018007392A2 (enExample) |
| CA (1) | CA3002255A1 (enExample) |
| CO (1) | CO2018004765A2 (enExample) |
| GB (1) | GB201518456D0 (enExample) |
| IL (1) | IL258707A (enExample) |
| MX (1) | MX2018004517A (enExample) |
| PH (1) | PH12018500827A1 (enExample) |
| RU (1) | RU2018117499A (enExample) |
| SG (1) | SG11201803095UA (enExample) |
| TW (1) | TW201718582A (enExample) |
| WO (1) | WO2017067848A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202340194A (zh) | 2017-02-16 | 2023-10-16 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| GB201702603D0 (en) * | 2017-02-17 | 2017-04-05 | Galápagos Nv | Novel compositions and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
| WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
| TWI721483B (zh) | 2018-07-13 | 2021-03-11 | 美商基利科學股份有限公司 | 吡咯并[1,2-b]嗒𠯤衍生物 |
| GB201904373D0 (en) * | 2019-03-29 | 2019-05-15 | Galapagos Nv | Novel compounds and pharamaceutical compositions thereof for the treatment of inflammatory disorders |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY28506A1 (es) * | 2003-09-12 | 2005-04-29 | Basf Ag | 6-halógeno-(1,2,4)triazolo(1,5-a)pirimidinas para combatir plagas animales. |
| ES2389203T3 (es) * | 2004-01-12 | 2012-10-24 | Ym Biosciences Australia Pty Ltd | Inhibidores de quinasa selectivos |
| US8653089B2 (en) * | 2011-02-09 | 2014-02-18 | F. Hoffmann-La Roche Ag | Heterocyclic compounds and methods of use |
| EP3049086A4 (en) * | 2013-09-27 | 2017-02-22 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| TW201609693A (zh) | 2014-01-03 | 2016-03-16 | 必治妥美雅史谷比公司 | 雜芳基取代之菸鹼醯胺化合物 |
-
2015
- 2015-10-19 GB GBGB1518456.7A patent/GB201518456D0/en not_active Ceased
-
2016
- 2016-10-14 EP EP16794525.2A patent/EP3365341B1/en active Active
- 2016-10-14 RU RU2018117499A patent/RU2018117499A/ru not_active Application Discontinuation
- 2016-10-14 CN CN201680060910.6A patent/CN108137584A/zh active Pending
- 2016-10-14 KR KR1020187013738A patent/KR20180064528A/ko not_active Withdrawn
- 2016-10-14 JP JP2018538935A patent/JP2018530617A/ja not_active Ceased
- 2016-10-14 WO PCT/EP2016/074662 patent/WO2017067848A1/en not_active Ceased
- 2016-10-14 MX MX2018004517A patent/MX2018004517A/es unknown
- 2016-10-14 BR BR112018007392A patent/BR112018007392A2/pt not_active Application Discontinuation
- 2016-10-14 US US15/769,260 patent/US10508111B2/en not_active Expired - Fee Related
- 2016-10-14 AU AU2016343225A patent/AU2016343225A1/en not_active Abandoned
- 2016-10-14 SG SG11201803095UA patent/SG11201803095UA/en unknown
- 2016-10-14 CA CA3002255A patent/CA3002255A1/en not_active Abandoned
- 2016-10-17 AR ARP160103166A patent/AR106384A1/es unknown
- 2016-10-18 TW TW105133608A patent/TW201718582A/zh unknown
-
2018
- 2018-04-15 IL IL258707A patent/IL258707A/en unknown
- 2018-04-17 PH PH12018500827A patent/PH12018500827A1/en unknown
- 2018-05-03 CO CONC2018/0004765A patent/CO2018004765A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016343225A1 (en) | 2018-05-10 |
| BR112018007392A2 (pt) | 2018-10-16 |
| CN108137584A (zh) | 2018-06-08 |
| AR106384A1 (es) | 2018-01-10 |
| RU2018117499A3 (enExample) | 2020-01-24 |
| RU2018117499A (ru) | 2019-11-21 |
| US10508111B2 (en) | 2019-12-17 |
| MX2018004517A (es) | 2018-06-27 |
| JP2018530617A (ja) | 2018-10-18 |
| EP3365341B1 (en) | 2020-05-13 |
| CA3002255A1 (en) | 2017-04-27 |
| SG11201803095UA (en) | 2018-05-30 |
| WO2017067848A1 (en) | 2017-04-27 |
| KR20180064528A (ko) | 2018-06-14 |
| PH12018500827A1 (en) | 2018-10-29 |
| US20180305351A1 (en) | 2018-10-25 |
| TW201718582A (zh) | 2017-06-01 |
| EP3365341A1 (en) | 2018-08-29 |
| GB201518456D0 (en) | 2015-12-02 |
| IL258707A (en) | 2018-06-28 |
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