TW201626982A - Cosmetic composition comprising stabilized effect material - Google Patents

Abstract

Disclosed is a cosmetic composition containing a stabilized active material. The cosmetic composition disclosed herein overcomes the problems of discoloration or odorization of an active material caused by a change in external conditions, such as pH or salt, in formulating an active material, and retains the titer of an active material. In addition, the cosmetic composition disclosed herein prevents breakage of a thickening system. Therefore, it is possible to provide a cosmetic composition having a stabilized formulation causing no coalescence of emulsion particles and phase separation.

Description

Cosmetic composition containing a stabilizing effect material

The present invention relates to a cosmetic composition comprising a chemically anisotropic powder and a stable active material.

Various methods for preparing particles of different shapes and particle sizes (nano particle size, micro particle size, etc.) have been reported. In particular, spherical particles containing a polymer have a particle size and shape which can be controlled according to the preparation method thereof, and thus have high applicability. For example, a Pickering emulsion using spherical particles to form stable coarse emulsion particles is provided.

The Pickering emulsion using solid spherical powder forms a W/O emulsion or an O/W emulsion depending on the wettability of the interface of the solid powder, that is, depending on the degree of lipophilicity and hydrophilicity. A contact angle therebetween is a factor that determines the orientation of the surface film. When the contact angle is less than 90°, a larger portion of the surface of the particle will have a liquid phase to form an O/W emulsion. At the same time, when the contact angle is greater than 90°, a larger portion of the surface of the particle will have an oil phase to form a W/O emulsion.

At the same time, various external conditions (pH, temperature, humidity, salt, or the like) should be controlled to maintain the potency of the various functional materials in the formulation. However, this change in external conditions may affect the interfacial film of the emulsion particles and the thickening system, thereby rendering the formulation unstable. Therefore, according to conventional emulsion preparations, certain problems such as discoloration, odor, or decrease in potency of the antioxidant active material may occur due to the surfactant/ionic polymer. Further, in some cases, the active material exhibits a high effect in the formulation, but provides a feeling of unpleasant use from discoloration or odor. In particular, when the salt-type active material is present in the formulation, the thickener system is destroyed, causing the emulsion particles to polymerize and phase separate, resulting in poor viscosity and stability of the formulation.

[Technical Problem] The technical problem to be solved by the present invention is to provide a cosmetic composition containing a stable preparation which overcomes the problem of discoloration or odor formation in the preparation of the active material, allows the retention of the active material, and prevents the thickening system. Breakage, thereby preventing polymerization and phase separation of the emulsion particles.

[Technical Solution] In a general aspect, there is provided a cosmetic composition comprising a stable active material, the cosmetic composition comprising a chemically asymmetric anisotropic powder and an active material, wherein the chemically asymmetric anisotropic powder Including a first hydrophilic polymer sphere and a second hydrophobic polymer sphere, the first and second polymer spheres are bonded to each other using a structure in which one polymer sphere is at least partially infiltrated into another polymer sphere, The first polymer sphere has a core-shell structure and the shell has a functional group.

According to a specific embodiment, the core of the second polymer sphere and the first polymer sphere may comprise a vinyl polymer, and the shell of the first polymer sphere may comprise a copolymer of a vinyl monomer having a functional group.

According to still another embodiment, the vinyl polymer may comprise polystyrene, or polymethylmethacrylate.

According to still another embodiment, the functional group can be a siloxane.

According to still another embodiment, the chemically asymmetric anisotropic particles may be non-hydrophilic.

According to still another embodiment, the chemically asymmetric anisotropic particles may have a particle size of from 100 to 1500 nm (nano).

According to still another embodiment, the chemically asymmetric anisotropic particles may be in an amount of from 0.1 to 15 (wt%) based on the total weight of the cosmetic composition.

According to still another embodiment, the active material may be a salt material.

According to yet another embodiment, the salt material (endogenous enhancers decrease, Endogenous Reducing Potentiator) of ERP ^TM, comprising trisodium fructose diphosphate (trisodium fructose diphosphate).

According to still another embodiment, the cosmetic composition can be a W/O or W/S (silicon) formulation.

According to still another embodiment, the cosmetic composition may comprise emulsion particles having a particle size of from 2 to 200 mm (micrometers).

According to still another specific embodiment, the cosmetic composition may comprise an alcohol.

According to still another embodiment, the cosmetic composition can be an emulsion composition, and the liquid phase portion of the emulsion composition can include a salt.

According to still another embodiment, the salt may be at least one selected from the group consisting of sodium chloride, potassium chloride, lithium chloride, calcium chloride. (calcium chloride), and magnesium chloride.

According to still another embodiment, the salt may be in an amount of from 0.01 to 5 (wt%) based on the total weight of the emulsion composition.

[Advantageous Effects] According to a specific embodiment of the present invention, there is provided a cosmetic composition having a stable preparation which overcomes a problem of discoloration or odorization of an active material due to a change in external conditions such as pH or salt in formulating an active material, It is permissible to maintain the potency of the active materials and to prevent breakage of the thickening system, thereby preventing polymerization and phase separation of the emulsion particles.

Exemplary embodiments are described in more detail below with reference to the drawings in which exemplary embodiments are shown. However, the invention may be embodied in many different forms and should not be construed as being limited to the exemplary embodiments disclosed. Rather, these embodiments are provided so that this disclosure will be more complete and complete. For the sake of clarity, the shapes, dimensions, regions, and the like of the illustrated elements may be particularly exaggerated in the drawings. Further, although the components constituting the components are shown for convenience, those skilled in the art should be able to easily understand the rest. In addition, it will be understood by those skilled in the art that various changes in form and detail may be made without departing from the scope of the invention as defined by the scope of the invention.

As used in this specification, unless otherwise indicated, "replacement" means that at least one hydrogen atom of a functional group described in this specification is replaced with the following: a halogen atom (F, Cl, Br or I), a hydroxyl group, a nitro group, a sub Imino group (=NH, =NR, where R is a C1-C10 alkyl group), amidino group, hydrazine or sulfhydryl group, carboxyl group, substitution or non-displacement C1 -C20 alkyl, substituted or non-substituted C3-C30 heteroaryl group, or substituted or non-substituted C2-C30 heterocycloalkyl.

As used herein, "(meth)acryl" means acrylic acid and/or methacryl.

As used in this specification, the particle size of the amphiphilic anisotropic particles is measured as the maximum length, which is the maximum length of the particles. As used in this specification, the particle size range of the amphiphilic anisotropic particles means that at least 95% of the amphiphilic anisotropic particles in the composition belong to the corresponding range.

As used herein, the average particle size of the emulsion particles refers to the average of the diameter of each particle. As used herein, the average particle size range of the emulsion particles means that at least 95% of the emulsion particles in the composition are in the corresponding ranges.

In one aspect, a cosmetic composition comprising a stable active material is provided, the cosmetic composition comprising a chemically asymmetric anisotropic particle and an active material, wherein the chemically asymmetric anisotropic particle comprises a first hydrophilicity a polymer sphere and a second hydrophobic polymer sphere, the first and second polymer spheres being bonded to each other using a structure in which a polymer sphere is at least partially infiltrated into another polymer sphere, the first polymer The sphere has a core-shell structure and the shell has a functional group.

As used herein, a sphere refers to a monomer formed from a polymer. For example, it may have a spherical or elliptical shape and have a micron- or nano-scale major axis length based on the maximum length of the monomer portion.

According to a specific embodiment, the core of the second polymer sphere and the first polymer sphere may comprise a vinyl polymer, and the shell of the first polymer sphere may comprise a copolymer of a vinyl polymer having a monomer having a functional group. Things.

According to another specific embodiment, the vinyl polymer may comprise a vinyl aromatic polymer, in particular polystyrene.

According to still another embodiment, the functional group can be a siloxane.

According to still another specific embodiment, at least one of the first polymer sphere and the second polymer sphere may comprise an ionic vinyl polymer.

According to still another embodiment, the ionic vinyl polymer can be a sodium 4-vinylbenzene sulfonate polymer.

According to still another embodiment, the functional group-containing monomer may be a siloxane-containing (meth)acrylate, in particular it may be 3-(trimethoxysilyl)propene. 3-(trimethoxysilyl) propyl acrylate, 3-(trimethoxysilyl)propyl methacrylate, vinyltriethoxysilane, Vinyltrimethoxysilane or a mixture thereof.

According to still another specific embodiment, the shell of the first polymer sphere may further comprise a hydrophilic functional group introduced thereto.

According to still another embodiment, the hydrophilic functional group may be a negatively or positively charged functional group or a polyethylene glycol (PEG) based functional group, and may be at least one selected from the group consisting of: carboxylic acid Group), sulfone group, phosphate group, amino group, alkoxy group, ester group, acetate group, polyethylene Alcohol group and hydroxyl group.

According to still another embodiment, the chemically asymmetric anisotropic particles may be non-hydrophilic. The chemically anisotropic powder having a geometric dumbbell-like shape can be formed into a stable water-in-oil type formulation by its strong emulsifying ability. The chemically anisotropic particles are formed by the strong physical bonding force between the particles to form coarse emulsion particles and a strong interfacial film. Thus, the active material can be loaded into a W/O or W/S formulation using the aforementioned characteristics to provide a stable formulation by dispersing the active material in the liquid phase to form a formulation. In addition, a stabilizing formulation can be provided for various external conditions to prevent discoloration of the active material and to achieve various usage sensations by controlling the oil, wax or water content of the formulation.

According to still another specific embodiment, the chemically asymmetric anisotropic particles may have an asymmetric snowman shape or an asymmetric inverted snowman shape.

According to still another embodiment, the chemically asymmetric anisotropic particles may have a particle size of from 100 to 1500 nm (nano). In one variant, the chemically asymmetric anisotropic particles may have a particle size of 100-500 nm (nano) or 200-300 nm (nano). In the present specification, the particle size refers to the maximum length of the amphiphilic particles. In particular, the chemically asymmetric anisotropic particles may have at least the following particle sizes: 100 nm (nano), at least 200 nm (nano), at least 300 nm (nano), at least 400 nm (nano), At least 500 nm (nano), at least 600 nm (nano), at least 700 nm (nano), at least 800 nm (nano), at least 900 nm (nano), at least 1000 nm (nano), at least 1100 Nm (nano), at least 1200 nm (nano), at least 1300 nm (nano), or at least 1400 nm (nano), with at most 1500 nm (nano), at most 1400 nm (nano), at most 1300 nm (nano), up to 1200 nm (nano), up to 1100 nm (nano), up to 1000 nm (nano), up to 900 nm (nano), up to 800 nm (nano), up to 700 nm (nano), up to 600 nm (nano), up to 500 nm (nano), up to 400 nm (nano), up to 300 nm (nano), or up to 200 nm (nano).

According to still another embodiment, the chemically asymmetric anisotropic particles may be present in an amount of from 0.1 to 15% by weight based on the total weight of the cosmetic composition. According to another specific embodiment, the chemically asymmetric anisotropic particles may be in an amount of from 0.5 to 5 (wt%) based on the total weight of the cosmetic composition. In particular, the chemically asymmetric anisotropic particles may be at least 0.1 wt%, at least 0.5 wt%, at least 1 wt%, at least 2 wt%, at least 4 wt%, at least 6 wt%, at least 8 wt% At least 10 wt%, or at least 12 wt%, and up to 15 wt%, up to 12 wt%, up to 10 wt%, up to 8 wt%, up to 6 wt%, up to 4 wt%, up to 2 wt%, up to 1 Wt%, or up to 0.5 wt%. The particle size of the emulsion particles can be controlled from several micrometers to tens or hundreds of micrometers by adjusting the content of the chemically asymmetric anisotropic particles.

The active material is one of the specific functions performed, such as whitening, anti-wrinkle or Elasticizing, and is under the supervision of the Food and Drug Safety Department, so that it can be used in an appropriate amount to provide the highest effect without causing skin trouble.

According to still another specific embodiment, the active material may be a salt material.

According to yet another embodiment, material may comprise salts trisodium fructose diphosphate (ERP ^TM). The cosmetic composition comprising chemically asymmetric anisotropic particles prevents discoloration of fructose trisodium phosphate (one of the salt active materials) and provides improved long-term stability.

According to still another embodiment, the chemically asymmetric anisotropic particles may be added together with a liquid phase portion to provide a cosmetic emulsion composition.

The cosmetic composition may be an emulsion composition, such as an oil-in-water (O/W) type formulation, comprising a chemically asymmetric anisotropic powder of 0.1-15:5-60:10-80 by weight, an oil phase fraction, With the liquid phase part. In one variant, the cosmetic composition may be an oil-in-water (O/W) type formulation comprising a chemically asymmetric anisotropic powder of 0.1-5:15-40:50-80 by weight, an oil phase fraction, With the liquid phase part. In another variant, the cosmetic composition may be a water-in-oil (W/O) type formulation comprising from 1 to 15:50 to 80:10 to 30 weight percent of chemically asymmetric anisotropic particles, an oil phase portion And the liquid phase part. The oil phase portion may comprise at least one selected from the group consisting of liquid oils and fats, solid oils and fats, waxes, hydrocarbon oils, high fatty acids, higher alcohols, synthetic ester oils, and silicone oils.

According to still another embodiment, the cosmetic composition may have a W/O or W/S (silicon) formulation.

According to still another embodiment, the water-in-oil emulsion composition may comprise emulsion particles having a particle size of from 2 to 200 mm (micrometers). In one variation, the water-in-oil emulsion composition may comprise coarse emulsion particles having a particle size of 10-100 mm (micrometers), 10-50 mm (micrometers), or 25 mm (micrometers). In particular, the water-in-oil emulsion composition may comprise emulsion particles having a particle size of at least 2 mm (micrometers), at least 5 mm (micrometers), at least 10 mm (micrometers), at least 15 mm (micrometers), at least 20 Mm (micron), at least 25 mm (micron), at least 30 mm (micron), at least 40 mm (micron), at least 50 mm (micron), at least 80 mm (micron), at least 100 mm (micron), at least 130 mm (micron), at least 150 mm (micrometer), or at least 180 mm (micrometer), and up to 200 mm (micrometer), up to 180 mm (micrometer), up to 150 mm (micrometer), up to 130 mm (micrometer), up to 100 Mm (micron), up to 80 mm (micron), up to 50 mm (micron), up to 40 mm (micron), up to 30 mm (micron), up to 25 mm (micron), up to 20 mm (micron), up to 15 mm (μm), up to 10 mm (micron), or up to 5 mm (micron).

Since the chemically asymmetric anisotropic particles have different orientations to the interface, they are capable of forming coarse emulsion particles and provide a formulation having a good feeling of use. It is not easy to form a stable coarse emulsion particle having a particle diameter of several tens of micrometers using a molecular-grade surfactant according to the related art, and the surfactant provides an interface film having a thickness of about several nanometers. However, in the case of the chemically asymmetric anisotropic particles disclosed in the present specification, the thickness of the interface film is increased to about several hundred nanometers, and the stable interface film can be formed by the strong bonding force between the particles, thereby significantly improving the emulsion. stability.

According to still another specific embodiment, the cosmetic composition can include ethanol. The chemically asymmetric anisotropic particles can be dispersed in ethanol and then added to the liquid phase portion to provide a cosmetic composition. C1-C4 low ethanol, polyol or a mixture thereof can be used as the ethanol. It can utilize a C1-C4 lower alcohol, a polyol or a mixture thereof to lower the freezing point of water, thus preventing the formation of coarse emulsion particles from causing a decrease in stability of freezing/thawing and improving stability.

The C1-C4 lower alcohol may be at least one selected from the group consisting of methanol, ethanol, and butanol, particularly ethanol.

The polyol may be a polyhydric alcohol, that is, the aliphatic compound has at least two hydroxyl groups (-OH). An aliphatic compound having a dihydroxy group is called a glycol or a diol. A typical example of an aliphatic compound having a trihydroxy group is glycerin, and an aliphatic compound having a tetrahydroxy group is pentaerythritol. In particular, the polyol may be at least one selected from the group consisting of butylene glycol, propylene glycol, dipropylene glycol, erythritol, xylitol, sorbitol ( Sorbitol), polyethylene glycol and isoprene glycol, but are not limited thereto.

According to still another specific embodiment, the cosmetic composition may be an emulsion composition, and the liquid phase portion of the water-in-oil emulsion composition may include a salt. When the salt is incorporated into the liquid phase portion, it allows the non-hydrophilic chemically asymmetric anisotropic particles to be placed between the water and the oil and stabilizes the interfacial film to provide a stable cosmetic composition.

According to still another embodiment, the salt may be at least one selected from the group consisting of sodium chloride, potassium chloride, lithium chloride, calcium chloride and magnesium chloride.

According to still another embodiment, the salt can be, for example, a content of from 0.01 to 5 wt% based on the total weight of the emulsion composition.

In another general aspect, a method for preparing a chemically asymmetric anisotropic particle is provided, the method comprising: (1) agitating a first monomer and a polymerization initiator to form a first polymer sphere (2) agitating a core forming a first polymer sphere with a first monomer, a polymerization initiator, and a functional group-containing compound to form a first polymer sphere having a coated core-shell structure; and (3) The first polymer sphere having a core-shell structure and a second monomer and a polymerization initiator are stirred to obtain an anisotropic powder forming the second polymer sphere.

In steps (1), (2) and (3), the agitation may be a rotary agitation. Since uniform mechanical mixing requires chemical modification to produce uniform particles, it is preferred to spin agitation. Spinning stirring can be carried out in a cylindrical reactor, but is not limited thereto.

In this specification, the internal design of the reactor can significantly affect the formation of particles. The size and position of the adjustment device of the barrel reactor, as well as the distance from the impeller, can significantly affect the uniformity of the particles to be formed. Preferably, the spacing between the inner vanes and the vanes of the impeller is minimal to create convection and uniformity of strength, the powdered reaction mixture will become below the length of the vanes, and the impeller will remain at a high rotational speed. The rotation speed can be 200 rpm or higher, and the ratio of the diameter to the reactor height can be 1-3:1-5. In particular, the reactor may have a diameter of 10-30 cm (cm) and a height of 10-50 cm (cm). The size change of the reactor can be proportional to the reaction capacity. Further, the cylindrical reactor can be made of ceramic, glass or the like. Stirring is preferably carried out at a temperature of from 50 to 90 °C.

Simple mixing in a cylindrical rotating reactor produces uniform particles, requires low energy consumption, and provides maximum reaction efficiency, and is therefore suitable for mass production. Conventional rolling methods involving the rotation of the reactor itself enable the entire component of the reactor to be tilted at a particular angle and rotated at high speeds, thus requiring high energy consumption and limiting reactor size. Due to reactor size limitations, the output is limited to traces of tens of milligrams to several grams. Therefore, the conventional scrolling method is not suitable for mass production.

According to a specific embodiment, the first monomer and the second monomer may be the same or different, and in particular, may be a vinyl monomer. Further, the first monomer added in the step (2) may be the same as the first monomer used in the step (1), and the initiator used in each step may be the same or different.

According to another specific embodiment, the vinyl monomer can be a vinyl aromatic monomer. The vinyl aromatic monomer may be a substituted or non-substituted styrene, such as at least one selected from the group consisting of styrene, alpha-methylstyrene, and ethyl styrene (Alpha-). Ethylstyrene), with para-methylstyrene.

According to still another specific embodiment, the polymerization initiator may be a radical polymerization initiator. In particular, the polymerization initiator may be at least one selected from the group consisting of peroxygen-based and azo-based initiators. Further, ammonium persulfate, sodium persulfate or potassium persulfate can be used. The peroxy radical polymerization initiator may be at least one selected from the group consisting of benzoyl peroxide, lauryl peroxide, and cumene hydroperoxide ( Cumene hydroperoxide), methylethyl ketone peroxide, t-butyl hydroperoxide, o-chlorobenzoyl peroxide, o-methylbenzhydryl peroxide (o) -methoxylbenzoyl peroxide), tert-Butyl peroxy-2-ethylhexanoate, and t-butylperoxy isobutyrate. The azo-based radical polymerization initiator may be at least one selected from the group consisting of 2,2'-azobisisobutyronitrile (2,2'-azobisisobutyronitrile) and 2,2'-azobis ( 2-methylisobutyronitrile (2,2'-azobis(2-methylisobutyronitrile)), and 2,2'-azobis(2,4-dimethylvaleronitrile) (2,2'-azobis ( 2,4-dimethylvaleronitrile)).

According to still another specific embodiment, in the step (1), the first monomer and the polymerization initiator may be mixed in a weight ratio of 100 to 250:1.

In a variant, in step (1), a stabilizer is a method of adding a first monomer and a polymerization initiator, the method being a first monomer, a polymerization initiator and a stabilizer may be 100-250:1. : 0.001 to 5 by weight ratio. The particle size and shape of the powder particles can be determined by controlling the particle size of the first polymer sphere in the step (1), and the particle diameter of the first polymer sphere can be obtained by the first monomer, the initiator and the stabilizer. Proportion to control. Further, the anisotropic powder uniformity can be increased by mixing the first monomer, the polymerization initiator, and the stabilizer within the aforementioned defined weight ratio range.

According to a specific embodiment, the stabilizer may be an ionic vinyl monomer, and in particular, sodium 4-vinylbenzene sulfonate may be used. The stabilizer prevents the expansion of the particles and generates a positive or negative charge on the surface of the particles, thereby preventing electrostatic polymerization (binding) of the particles.

When the chemically anisotropic powder has a particle diameter of 200-250 nm (nano), it may be from a ratio of 110-130:1:2-4, especially 115-125:1:2-4, and more special It is obtained by a first polymer sphere of a first monomer, an initiator and a stabilizer of a ratio of 120:1:3.

Further, when the chemically anisotropic particles have a particle diameter of 400 to 450 nm (nano), they may have a ratio of from 225 to 240:1:1 to 3, particularly from 230 to 235:1:1 to 3. More particularly, the first polymer sphere of the first monomer, initiator and stabilizer of the 235:1:2 ratio is obtained.

Further, when the chemically anisotropic particles have a particle size of 1100 to 1500 nm (nano), they may have a ratio of 110 to 130:1:0, particularly 115 to 125:1:0, and more particularly 120. : 1:0 ratio of the first monomer, the initiator and the first polymer sphere of the stabilizer are obtained.

Further, the chemically anisotropic powder having an asymmetric snowman shape can be obtained by reacting at a ratio of 100-140:1:8-12, particularly 110-130:1:9-11, and more particularly 120:1:10 The first polymer sphere prepared from the first monomer, the initiator and the stabilizer is obtained.

Furthermore, the chemically anisotropic particles having the shape of an asymmetric inverted snowman can be reacted by a ratio of 100-140:1:1-5, especially 110-130:1:2-4, and more particularly 120:1. : 3 ratios of the first monomer, the initiator and the first polymer sphere prepared from the stabilizer are obtained.

According to another specific embodiment, in the step (2), the functional group-containing monomer may be a silicone-containing compound. In particular, the functional group-containing monomer may be a siloxane-containing (meth) acrylate polymer, and may be at least one selected from the group consisting of 3-(trimethoxysilyl) propyl acrylate 3-(trimethoxysilyl) propyl acrylate, 3-(trimethoxysilyl)propyl methacrylate, vinyltriethoxysilane and vinyl Trimethyl silane (vinyltrimethoxysilane).

According to still another embodiment, in the step (2), the first monomer, the polymerization initiator and the functional group-containing monomer may be mixed in a weight ratio of 80 to 98: 0.2 to 0.8: 2 to 20. In a variant, the first monomer, the polymerization initiator and the functional group-containing monomer may be mixed in a weight ratio of from 160 to 200:1:6 to 40. It can control the degree of coating according to the reaction ratio, and then the degree of coating can determine the shape of the amphiphilic anisotropic powder. When the first monomer, the polymerization initiator and the functional group-containing compound are used within the above defined ratio range, the coating thickness may be increased by about 10 to 30%, particularly about 20%, based on the initial thickness. In this case, the powder can be smoothly formed without problems, such as the formation of powder particles caused by excessively thick coating, or the excessively thin coating, which causes multi-directional formation of the particles. Further, it can increase the uniformity of anisotropic particles within the aforementioned weight ratio range.

According to still a specific embodiment, in the step (3), the second monomer and the polymerization initiator may be mixed in a weight ratio of 200 to 250:1.

In a variant, in step (3), a stabilizer may take a method to add a second monomer and a polymerization initiator, the method being a second monomer, the polymerization initiator and the stabilizer may be 200-250:1 : 0.001-5 by weight ratio. Specific examples of the stabilizer are the same as described above. It can increase the uniformity of anisotropic particles within the aforementioned weight ratio range.

According to still another embodiment, in step (3), the second monomer may be a 40-300% content based on 100% by weight of the first polymer sphere having a core-shell structure. In particular, when the content of the second monomer is 40-100% based on the weight of the first polymer sphere, an asymmetric snowman-like powder can be obtained. Symmetrical granules are obtained when the content of the second monomer is from 100 to 150% or from 110 to 150% by weight based on the weight of the first polymer sphere. Further, when the content of the second monomer is 150-300% or 160-300% based on the weight of the first polymer sphere, an asymmetric inverted snowman-like powder can be obtained. It can increase the uniformity of anisotropic particles within the aforementioned weight ratio range.

According to still a specific embodiment, the method for preparing the amphiphilic anisotropic particles may further comprise the step (4), that is, after the step (3), the hydrophilic functional group is introduced into the anisotropic particles.

According to still another embodiment, in the step (4), a hydrophilic functional group is introduced using a silane coupling agent and a reaction modifier, but is not limited thereto.

According to still another embodiment, the silane coupling agent may be at least one selected from the group consisting of (3-aminopropyl) trimethoxysilane, N-[3- (N-[3-(trimethoxysilyl)propyl]ethylenediamine), N-[3-(trimethoxysilyl)propyl]ethylenediamine chloride (N-[3 -(trimethoxysilyl)propyl]ethylenediammonium chloride), (N-succinyl-3-aminopropyl)trimethoxysilane, 1-3-(trimethoxy) 1-[3-(trimethoxysilyl)propyl]urea), and 3-(trimethoxysilyl)propoxy-1,2-propanediol (3-[(trimethoxysilyl)propyloxy]- 1,2-propanediol). In particular, the silane coupling agent may be N-[(3-trimethoxysilyl)propyl]ethylenediamine.

According to still another embodiment, the silane coupling agent may be based on the weight of the anisotropic powder obtained from step (3) of 100%, incorporation of a content of 35-65%, such as a content of 40-60%. It can achieve proper hydrophilization within the aforementioned definitions.

According to still another embodiment, the reaction modifier can be ammonium hydroxide.

According to still another specific embodiment, the reaction modifier may be based on obtaining 100% by weight of the anisotropic powder from the step (3), incorporating a content of 85-115%, such as a content of 90-110%. It can achieve proper hydrophilization within the aforementioned definitions.

According to the related art, many attempts have been made to increase the surface activity characteristics of spherical powder particles of Pickering emulsion by adding active characteristics to the surface of the amphiphile. This has been exemplified by a non-central symmetric spherical particle (Janus spherical particle). However, this particle is geometrically limited and has problems from the viewpoint of uniform mass production, and thus cannot be practically applied. In contrast, the method of preparing the chemically anisotropic particles disclosed in the present specification does not use a crosslinking agent, so that polymerization is not caused, and high yield and uniformity are provided. In addition, the method disclosed in the present specification uses a simple agitation process and is more suitable for mass production than a rolling process. In particular, the method disclosed in the present specification has an advantage in that it allows generation of particles having a particle diameter of 300 nm (nano) or less on a large scale of several tens of grams and several tens of kilograms.

[Embodiment Mode] Exemplary embodiments will now be described in more detail with reference to the accompanying drawings, in which exemplary embodiments are shown. However, the invention may be embodied in many different forms and should not be construed as being limited to the exemplary embodiments disclosed herein.

[Preparation Example 1] Preparation of polystyrene (PS) first polymer sphere styrene (as a monomer), sodium p-styrene sulfonate (as a stabilizer), and azobisisobutyronitrile (AIBN, azobisisobutyronitrile) (as an initiator) is mixed in a liquid phase and allowed to react at 75 ° C for 8 hours. The reaction was carried out by stirring the reaction mixture at a speed of 200 rpm at a diameter of 11 cm (cm) and a height of 17 cm (cm) in a cylindrical reactor made of glass.

[Preparation Example 2] Preparation of coated first polymer sphere having a core-shell (CS) structure Polystyrene (PS) obtained from the foregoing The first polymer spherical particles were mixed styrene (as a monomer), 3 - (Trimethoxysilyl) propyl acrylate (TMSPA) with azobisisobutyronitrile (AIBN) (as initiator) and allowing the reaction mixture to react. The reaction is carried out by stirring the reaction mixture in a cylindrical reactor.

[Preparation Example 3] Preparation of anisotropic powder particles The aqueous dispersion of the polystyrene core-shell (PC-CS) dispersion obtained as described above was mixed with styrene (as a monomer), sodium p-styrenesulfonate (when As a stabilizer), with azobisisobutyronitrile (AIBN) (as an initiator), and the reaction mixture was heated to 75 ° C for reaction. The reaction is carried out by stirring the reaction mixture in a cylindrical reactor. In this way, an amphiphilic anisotropic powder is obtained.

[Preparation Example 4] Preparation of hydrophilic amphiphilic anisotropic powder particles In order to obtain an aqueous dispersion of an anisotropic powder of 600 g (g) as described above, 30 g (g) of N-[3-(trimethoxysilyl) was added. Propyl]ethylenediamine was used as a silane coupling agent, and 60 g (g) of ammonium hydroxide was used as a reaction modifier, and then mixed and reacted at 25 ° C for 24 hours to introduce a hydrophilic functional group. The reaction is carried out by stirring the reaction mixture in a cylindrical reactor. Thus, hydrophilic amphiphilic anisotropic particles were obtained.

[Comparative Example 1] ERP ^TM (endogenous reduction enhancer) was used to obtain an aqueous ERP solution as shown in Table 1 below. [Table 1]

[Comparative Example 2] The O/W preparation shown in Table 2 below was obtained by a conventional method. [Table 2]

[Comparative Example 3] The W/O preparations as shown in Table 3 below were obtained by a conventional method. [table 3]

[Example 1] The anisotropic powder (DB) obtained from Preparation Example 3 was used to obtain a W/S preparation containing ERP, as shown in Table 4 below. [Table 4]

[Test Example 1] - Evaluation of appearance change at high temperature with time The composition according to Example 1 and Comparative Examples 1-3 was stored at 60 ° C for 1 week to observe a change in appearance such as discoloration. Figure 1 shows a diagram illustrating the change in the appearance of the composition after storage of the composition at 60 ° C for one week, wherein (a) shows an aqueous ERP solution (Comparative Example 1); (b) shows an O/W formulation (Comparative Example 2) (c) shows a W/O formulation (Comparative Example 3); and (d) shows an S/W formulation containing anisotropic particles (Example 1).

As shown in FIG. 1, the composition according to the comparative example showed a change in appearance such as discoloration; the composition according to Example 1 showed no change in appearance, such as discoloration.

[Example 2-5] The anisotropic powder obtained from Preparation Example 3 was used to obtain a W/S preparation shown in Table 5 below. Example 2 is a composition containing 0 wt% NaCl, pH 5.7; Example 3 is a composition containing 6 wt% NaCl, pH 5.7; Example 4 is a composition containing 0 wt% NaCl, pH 1.5; and Example 5 is containing Composition of 0 wt% NaCl, pH 9.0. [table 5]

[Test Example 2] - Evaluation of Stability of Emulsion Particles The emulsion composition according to Examples 2 to 5 was observed at 25 ° C using an optical microscope to determine the state of the emulsion particles. The results are shown in Figure 2.

As shown in Figure 2, each cosmetic composition containing the stable active material according to Examples 2-5 maintained stable emulsion particles even at pH 1.5-9 of 0-6% salt (see Figure 1).

[Test Example 3] - Determination of ERP activity titer The composition according to Example 1 was kept at room temperature (25 ° C) and 40 ° C, and then ERP titer was measured according to the following method. The results are shown in Table 6 below.

[Method for measuring ERP titer] Approximately 0.5 g (g) of the sample was accurately weighed and dispersed in 20 mL (ml) of water. Water was then added to a total volume of 100 mL (ml) and the dispersion was filtered as needed to provide a sampling solution. In a separate vessel, a standard product of about 14 mg (mg) of fructose diphosphate trisodium octahydrate was weighed and dissolved in water to a total volume of 100 mL (ml). Then, 25 mL (ml) of the solution was taken out and water was added to a total volume of 100 mL (ml) to provide a standard solution. Thereafter, each 25 mL (microliter) sampling solution and the standard solution were subjected to ion chromatography under the following conditions to obtain the peak areas of fructose diphosphate: At and As (the amount of fructose diphosphate (mg) = standard generation Quantity (mg (mg)) × At/As x 0.25 × 0.738). However, unless otherwise stated, other conditions are to follow conventional liquid chromatography (using the xterra RP 18 column from Waters Co., USA). Then, the potency is calculated as a percentage based on the initial value of the amount of fructose diphosphate diphosphate obtained as described above. [Table 6]

As shown in Table 6, when the ERP activity titer was determined, the composition according to Example 1 did not cause a significant decrease in potency even after 8 weeks at a high temperature (40 ° C), indicating that the composition can maintain ERP even at high temperatures. Potency, so the ERP of the composition will be stable.

As can be seen from the foregoing, since the cosmetic composition containing the stable active material disclosed in the present specification includes chemically anisotropic powder particles, it is possible to overcome the problem of discoloration or odor of the active material caused by changes in external conditions such as pH or salt, and to maintain activity. The potency of the material. In addition, the cosmetic compositions disclosed herein prevent breakage of the thickening system. Thus, it is possible to provide a cosmetic composition having a stable formulation which does not cause polymerization and phase separation of the emulsion particles.

While the invention has been shown and described with reference to the embodiments of the present invention, it is understood that various changes in form and details may be made without departing from the scope of the invention as defined by the appended claims. Therefore, it is intended that the scope of the invention be construed as

1 is a diagram showing the appearance change of a cosmetic composition containing 0.5 wt% ERP according to an embodiment of the present invention after long-term storage (1 week at 60 ° C), wherein (a) shows an aqueous ERP Solution (Comparative Example 1); (b) shows O/W formulation (Comparative Example 2); (c) shows W/O formulation (Comparative Example 3); and (d) shows S/W formulation (Example 1), Contains dumbbell-shaped powder.

2 is a diagram showing changes in pH and salt emulsion particles depending on a W/S formulation containing an ERP according to an embodiment of the present invention, wherein (a) is shown in NaCl 0% , emulsion particles at pH 5.7; (b) emulsion particles showing NaCl at 6%, pH 5.7; (c) emulsion particles showing NaCl at 0%, pH 1.5; and (d) showing in NaCl Emulsion particles at 0%, pH 9.0.

Claims (15)

A cosmetic composition comprising a stable active material, the cosmetic composition comprising a chemically asymmetric anisotropic powder and an active material, wherein the chemically asymmetric anisotropic particle comprises a first hydrophilic polymer sphere and a first a second hydrophobic polymer sphere, the first hydrophilic polymer sphere and the second hydrophobic polymer sphere being bonded to each other using a structure, wherein one of the polymer spheres at least partially penetrates into the other polymer sphere The first hydrophilic polymer sphere has a core-shell structure, and the shell has a functional group. The cosmetic composition containing a stable active material according to claim 1, wherein the core of the second hydrophobic polymer sphere and the first hydrophilic polymer sphere comprises a vinyl polymer, and the first hydrophilic polymer The shell of the sphere comprises a copolymer having a vinyl monomer containing a functional group monomer. A cosmetic composition comprising a stable active material according to claim 2, wherein the vinyl polymer is polystyrene. A cosmetic composition containing a stable active material according to claim 1, wherein the functional group is a siloxane. A cosmetic composition containing a stable active material according to claim 1, wherein the chemically asymmetric anisotropic powder is non-hydrophilic. The cosmetic composition containing a stable active material according to claim 1, wherein the chemically asymmetric anisotropic particles have a particle diameter of 100 to 1500 nm (nano). The cosmetic composition containing a stable active material according to claim 1, wherein the chemically asymmetric anisotropic powder particles are in an amount of 0.1 to 15% by weight based on the total weight of the cosmetic composition. A cosmetic composition containing a stable active material according to claim 1, wherein the active material is a salt material. A cosmetic composition comprising a stable active material according to claim 8, wherein the salt material comprises trisodium fructose diphosphate. A cosmetic composition containing a stable active material as claimed in claim 1 which has a W/O or W/S (silicon) formulation. A cosmetic composition containing a stable active material as claimed in claim 1 which comprises emulsion particles having a particle diameter of from 2 to 200 mm (micrometer). A cosmetic composition containing a stable active material according to claim 1, which comprises an alcohol. A cosmetic composition containing a stable active material according to claim 1, which is an emulsion composition, wherein a liquid phase portion of the emulsion composition contains a salt. A cosmetic composition comprising a stable active material according to claim 13, wherein the salt is at least one selected from the group consisting of sodium chloride, potassium chloride, lithium chloride, calcium chloride and magnesium chloride. A cosmetic composition comprising a stable active material according to claim 13, wherein the salt is in an amount of from 0.01 to 5% by weight based on the total weight of the emulsion composition.