TW201443064A - 經雜芳基取代之六氫哌喃並［３，４－ｄ］［１，３］噻□－２－胺化合物 - Google Patents
經雜芳基取代之六氫哌喃並［３，４－ｄ］［１，３］噻□－２－胺化合物 Download PDFInfo
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- TW201443064A TW201443064A TW103104416A TW103104416A TW201443064A TW 201443064 A TW201443064 A TW 201443064A TW 103104416 A TW103104416 A TW 103104416A TW 103104416 A TW103104416 A TW 103104416A TW 201443064 A TW201443064 A TW 201443064A
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- Taiwan
- Prior art keywords
- difluorophenyl
- compound
- tautomer
- hexahydropyrano
- methyl
- Prior art date
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- QRXWUHYBXASSFN-UHFFFAOYSA-N 1,2,4,4a,5,6-hexahydropyrano[3,4-d][1,3]thiazin-2-amine Chemical class O1CCC2CSC(N)NC2=C1 QRXWUHYBXASSFN-UHFFFAOYSA-N 0.000 title 1
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- JBMKAUGHUNFTOL-UHFFFAOYSA-N Aldoclor Chemical class C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NC=NS2(=O)=O JBMKAUGHUNFTOL-UHFFFAOYSA-N 0.000 claims description 138
- 239000003451 thiazide diuretic agent Substances 0.000 claims description 138
- -1 cyano, methyl Chemical group 0.000 claims description 85
- CNPURSDMOWDNOQ-UHFFFAOYSA-N 4-methoxy-7h-pyrrolo[2,3-d]pyrimidin-2-amine Chemical compound COC1=NC(N)=NC2=C1C=CN2 CNPURSDMOWDNOQ-UHFFFAOYSA-N 0.000 claims description 70
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 48
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- 125000000217 alkyl group Chemical group 0.000 claims description 16
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- 125000003545 alkoxy group Chemical group 0.000 claims description 6
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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| CN107235978B (zh) * | 2017-08-01 | 2019-05-21 | 上海泓博智源医药股份有限公司 | 一种abt-199中间体的制备方法 |
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-
2014
- 2014-02-03 WO PCT/IB2014/058760 patent/WO2014125394A1/en not_active Ceased
- 2014-02-03 CA CA2897678A patent/CA2897678A1/en not_active Abandoned
- 2014-02-03 EP EP14704927.4A patent/EP2956458B1/en not_active Not-in-force
- 2014-02-03 JP JP2015556596A patent/JP2016507551A/ja active Pending
- 2014-02-11 TW TW103104416A patent/TW201443064A/zh unknown
- 2014-02-12 UY UY0001035320A patent/UY35320A/es not_active Application Discontinuation
- 2014-02-12 US US14/178,470 patent/US8865706B2/en not_active Expired - Fee Related
- 2014-02-12 AR ARP140100441A patent/AR094762A1/es unknown
- 2014-08-21 US US14/464,935 patent/US9045499B2/en not_active Expired - Fee Related
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2015
- 2015-04-23 US US14/694,288 patent/US9192612B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US9192612B2 (en) | 2015-11-24 |
| US8865706B2 (en) | 2014-10-21 |
| EP2956458A1 (en) | 2015-12-23 |
| US20140364426A1 (en) | 2014-12-11 |
| CA2897678A1 (en) | 2014-08-21 |
| JP2016507551A (ja) | 2016-03-10 |
| US20140228356A1 (en) | 2014-08-14 |
| EP2956458B1 (en) | 2017-08-09 |
| UY35320A (es) | 2014-09-30 |
| US9045499B2 (en) | 2015-06-02 |
| US20150224110A1 (en) | 2015-08-13 |
| AR094762A1 (es) | 2015-08-26 |
| WO2014125394A1 (en) | 2014-08-21 |
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