TW201348215A - 雜環化合物 - Google Patents

Info

Publication number

TW201348215A

TW201348215A TW102108642A TW102108642A TW201348215A TW 201348215 A TW201348215 A TW 201348215A TW 102108642 A TW102108642 A TW 102108642A TW 102108642 A TW102108642 A TW 102108642A TW 201348215 A TW201348215 A TW 201348215A

Authority

TW

Taiwan

Prior art keywords

group

lower alkyl

depression

disorder

disease

Prior art date

2012-03-12

Links

• Espacenet
• Global Dossier
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• 150000002391 heterocyclic compounds Chemical class 0.000 title claims abstract description 42
• 125000000217 alkyl group Chemical group 0.000 claims abstract description 192
• 150000003839 salts Chemical class 0.000 claims abstract description 38
• 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 32
• 125000003118 aryl group Chemical group 0.000 claims abstract description 20
• 125000001424 substituent group Chemical group 0.000 claims abstract description 18
• 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 14
• 239000001257 hydrogen Substances 0.000 claims abstract description 14
• 125000006239 protecting group Chemical group 0.000 claims abstract description 11
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 8
• 150000002431 hydrogen Chemical group 0.000 claims abstract description 6
• -1 (3) benzothienyl Chemical group 0.000 claims description 335
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 140
• 150000001875 compounds Chemical class 0.000 claims description 116
• 125000003545 alkoxy group Chemical group 0.000 claims description 57
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 47
• 239000000725 suspension Substances 0.000 claims description 38
• 239000003814 drug Substances 0.000 claims description 33
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 32
• 208000002193 Pain Diseases 0.000 claims description 29
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 28
• QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims description 28
• UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 27
• VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 26
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• 230000000069 prophylactic effect Effects 0.000 claims description 15
• SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 claims description 14
• YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 14
• SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 claims description 14
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• 125000000335 thiazolyl group Chemical group 0.000 claims description 14
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• QEYQSYAGLRIYBE-UHFFFAOYSA-N 2,3,4,5-tetrahydro-1h-1,2-benzodiazepine Chemical compound C1CCNNC2=CC=CC=C21 QEYQSYAGLRIYBE-UHFFFAOYSA-N 0.000 claims description 9
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