TW201340971A - Ｄｎａ損傷劑 - Google Patents

Ｄｎａ損傷劑 Download PDF

Info

Publication number
TW201340971A
TW201340971A TW102108245A TW102108245A TW201340971A TW 201340971 A TW201340971 A TW 201340971A TW 102108245 A TW102108245 A TW 102108245A TW 102108245 A TW102108245 A TW 102108245A TW 201340971 A TW201340971 A TW 201340971A
Authority
TW
Taiwan
Prior art keywords
cancer
dna
deoxy
fluorouracil
thio
Prior art date
Application number
TW102108245A
Other languages
English (en)
Chinese (zh)
Inventor
Makoto Nomura
Hiromi Kazuno
Original Assignee
Taiho Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd filed Critical Taiho Pharmaceutical Co Ltd
Publication of TW201340971A publication Critical patent/TW201340971A/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW102108245A 2012-03-09 2013-03-08 Ｄｎａ損傷劑 TW201340971A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2012053517 2012-03-09

Publications (1)

Publication Number Publication Date
TW201340971A true TW201340971A (zh) 2013-10-16

Family

ID=49116867

Family Applications (1)

Application Number Title Priority Date Filing Date
TW102108245A TW201340971A (zh) 2012-03-09 2013-03-08 Ｄｎａ損傷劑

Country Status (2)

Country Link
TW (1) TW201340971A (fr)
WO (1) WO2013133399A1 (fr)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2253732T3 (es) * 1989-09-15 2006-06-01 Southern Research Institute 2'-deoxi-4'-tioribonucleosidos como agentes antivirales y anticancerosos.
IE74701B1 (en) * 1989-10-04 1997-07-30 Univ Birmingham Further antiviral pyrimidine nucleosides
GB9218810D0 (en) * 1992-09-04 1992-10-21 Univ Birmingham Antiviral pyrimidine nucleosides
WO2003026675A1 (fr) * 2001-09-28 2003-04-03 Idenix (Cayman) Limited Procedes et compositions pour traiter des flavivirus et des pestivirus au moyen d'un nucleoside modifie en position 4'

Also Published As

Publication number Publication date
WO2013133399A1 (fr) 2013-09-12

Similar Documents

Publication Publication Date Title
RU2488591C2 (ru) Аналоги азацитидина и их применение
CN102459300A (zh) 用于治疗用途的新的7-脱氮嘌呤核苷
US11248016B2 (en) Glycolipids and pharmaceutical compositions thereof for use in therapy
CN107721959A (zh) 杨梅素衍生物及制备方法，及其在治疗结肠炎、防治结肠炎癌转化和治疗结直肠癌中的应用
JP2022525156A (ja) 修飾されたマイクロｒｎａ及びがんの処置におけるその使用
JP6142098B1 (ja) ５−アザシチジン又は其の２’−デオキシ体の５’位ジベンジル燐酸エステル
CN105263501A (zh) 具有抗转移活性的糖-类似物含磷杂环
WO2019160127A1 (fr) Utilisation d'un inhibiteur de dnmt
CN112513000A (zh) 新型联苯衍生物化合物及其用途
TW201340971A (zh) Ｄｎａ損傷劑
EP2636677B1 (fr) Dérivé de carboxamide de pyrrolopyrimidinone inhibant les cdk ou sel pharmaceutiquement acceptable de celui-ci, et composition pharmaceutique contenant ce dérivé comme principe actif et destinée à prévenir ou à traiter un carcinome hépatocellulaire
CN109846873B (zh) 一种抗肿瘤药物组合物
US10751358B2 (en) Multitargeted nucleoside derivatives
US20220281910A1 (en) Dinucleotide compounds for treating cancers and medical uses thereof
WO2017080313A1 (fr) Dérivé de tétrahydropalmatine, son procédé de préparation et utilisation
CN109528664B (zh) 含乌苯美司-抗肿瘤药物协同前药衍生物的冻干粉剂及其制备方法
US11173174B2 (en) DNMT inhibitor as solid tumor therapeutic drug
CN109646429B (zh) 一种含乌苯美司的前药衍生物的固体剂型及其制备方法
CN108186630B (zh) 靛红类似物在制备抗肿瘤药物中的应用
RU2471486C2 (ru) Противоопухолевое средство для непрерывного внутривенного введения, содержащее цитидиновое производное
US20220347197A1 (en) Use of dnmt inhibitor
WO2020090698A1 (fr) Composition pharmaceutique
TW202140018A (zh) 含有尿嘧啶衍生物化合物之抗腫瘤效果增強劑
US8586561B2 (en) Anti-tumor agent comprising cytidine derivative and carboplatin
EP2174930A1 (fr) Agent anti-tumoral comprenant de la sulfostine et un composé apparenté à la sulfostine comme principe actif