TW201319063A - 以四氫噻唑衍生物或其鹽為有效成分之醫藥品 - Google Patents

以四氫噻唑衍生物或其鹽為有效成分之醫藥品 Download PDF

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Publication number
TW201319063A
TW201319063A TW101136757A TW101136757A TW201319063A TW 201319063 A TW201319063 A TW 201319063A TW 101136757 A TW101136757 A TW 101136757A TW 101136757 A TW101136757 A TW 101136757A TW 201319063 A TW201319063 A TW 201319063A
Authority
TW
Taiwan
Prior art keywords
methylene
phenyl
tetrahydrothiazole
dione
methyl
Prior art date
Application number
TW101136757A
Other languages
English (en)
Chinese (zh)
Inventor
Atsuhiro Abe
Ryuta Yamazaki
Toshio Sasai
Takashi Yaegashi
Masato Nagaoka
Akimitsu Takagi
Takeshi Matsuzaki
Masayuki Mae
Takuya Sugimoto
Tsuneyuki Kobayashi
Hiroyuki Nishiyama
Yuichi Sawaguchi
Yukiko Nishiyama
Original Assignee
Yakult Honsha Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yakult Honsha Kk filed Critical Yakult Honsha Kk
Publication of TW201319063A publication Critical patent/TW201319063A/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TW101136757A 2011-10-04 2012-10-04 以四氫噻唑衍生物或其鹽為有效成分之醫藥品 TW201319063A (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2011220338 2011-10-04

Publications (1)

Publication Number Publication Date
TW201319063A true TW201319063A (zh) 2013-05-16

Family

ID=48043825

Family Applications (1)

Application Number Title Priority Date Filing Date
TW101136757A TW201319063A (zh) 2011-10-04 2012-10-04 以四氫噻唑衍生物或其鹽為有效成分之醫藥品

Country Status (3)

Country Link
JP (1) JP6057907B2 (ja)
TW (1) TW201319063A (ja)
WO (1) WO2013051672A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106170480A (zh) * 2014-05-09 2016-11-30 上海科胜药物研发有限公司 新的沃替西汀中间体及其合成方法
CN107188901A (zh) * 2017-05-27 2017-09-22 无锡捷化医药科技有限公司 一种(3‑(3‑(二甲氨基)丙氧基)苯基)硼酸的制备方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6023630B2 (ja) * 2013-04-03 2016-11-09 株式会社ヤクルト本社 チアゾロン誘導体
US9828348B2 (en) 2013-11-08 2017-11-28 Purdue Pharma L.P. Benzimidazole derivatives and use thereof
GB201321740D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
WO2018213731A1 (en) 2017-05-18 2018-11-22 Modernatx, Inc. Polynucleotides encoding tethered interleukin-12 (il12) polypeptides and uses thereof
CN113717100B (zh) * 2021-10-11 2023-03-17 郑州工业应用技术学院 一种培氟沙星醛缩4-芳基氨基硫脲类衍生物的制备方法
CN114213424B (zh) * 2021-12-30 2023-05-26 杭州高光制药有限公司 一种呋喃[3，2-b]并吡啶衍生物的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1786812T1 (sl) * 2004-09-03 2011-12-30 Merck Serono Sa Piridin metilen azolidinoni in njihova uporaba kot inhibitorji fosfoinozitida
JP5357763B2 (ja) * 2006-11-06 2013-12-04 トレロ ファーマシューティカルズ， インコーポレイテッド イミダゾ［１，２−ｂ］ピリダジン誘導体およびピラゾロ［１，５−ａ］ピリダジン誘導体およびプロテインキナーゼインヒビターとしてのこれらの使用
TWI461423B (zh) * 2008-07-02 2014-11-21 Astrazeneca Ab 用於治療Pim激酶相關病狀及疾病之噻唑啶二酮化合物
JP5472642B2 (ja) * 2008-09-26 2014-04-16 日本電気株式会社 信号処理方法、信号処理装置、および信号処理プログラム
MX2011012369A (es) * 2009-05-20 2012-03-16 Cylene Pharmaceuticals Inc Pirazolopirimidinas y heterociclos relacionados como inhibidores de cinasa.
BR112012005550A2 (pt) * 2009-09-11 2015-09-08 Cylene Pharmaceuticals Inc lactamas heterociclo-substituídas farmaceuticamente úteis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106170480A (zh) * 2014-05-09 2016-11-30 上海科胜药物研发有限公司 新的沃替西汀中间体及其合成方法
CN107188901A (zh) * 2017-05-27 2017-09-22 无锡捷化医药科技有限公司 一种(3‑(3‑(二甲氨基)丙氧基)苯基)硼酸的制备方法

Also Published As

Publication number Publication date
WO2013051672A1 (ja) 2013-04-11
JP6057907B2 (ja) 2017-01-11
JPWO2013051672A1 (ja) 2015-03-30

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