TW201309215A - Soy milk having additive of Vitamin C, Vitamin C salt and Vitamin C or Vitamin C stereoisomers - Google Patents

Soy milk having additive of Vitamin C, Vitamin C salt and Vitamin C or Vitamin C stereoisomers Download PDF

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TW201309215A
TW201309215A TW100129310A TW100129310A TW201309215A TW 201309215 A TW201309215 A TW 201309215A TW 100129310 A TW100129310 A TW 100129310A TW 100129310 A TW100129310 A TW 100129310A TW 201309215 A TW201309215 A TW 201309215A
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vitamin
iron
soy milk
ascorbic acid
ascorbate
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TWI437963B (en
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Tzu-Ming Pan
Cheng-Lun Wu
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Sunway Biotech Co Ltd
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Abstract

The present invention relates to a soy milk having additive of Vitamin C, Vitamin C salt and Vitamin C or Vitamin C stereoisomers. The soy milk having the additive of Vitamin C is made by adding an ascorbic acid into a drink fabricated by using at least one bean as raw materials, and the soy milk having Vitamin C is helpful to increase the absorption rate of iron in small intestine, wherein the dose of the ascorbic acid is ranged in 25 to 50 mg/100mL. The soy milk having the additive of Vitamin C salt is made by adding an ascorbic acid salt into a drink fabricated by using at least one bean as raw materials, and the dose of the ascorbic acid ion provided by the ascorbic acid salt is ranged in 25 to 50 mg/100mL. Besides, The soy milk having the additive of Vitamin C stereoisomers is made by adding an ascorbic acid stereoisomers into a drink fabricated by using at least one bean as raw materials, and the dose of the ascorbic acid ion provided by the ascorbic acid stereoisomers is ranged in 25 to 50 mg/100mL.

Description

添加維生素C、維生素C鹽類或維生素C立體異構物之豆奶Soymilk added with vitamin C, vitamin C salts or vitamin C stereoisomers

本發明係關於一種豆奶,尤指一種添加維生素C、維生素C鹽類或維生素C立體異構物之豆奶,具有增加小腸對鐵的吸收率之功效。The invention relates to a soy milk, in particular to a soy milk supplemented with a vitamin C, a vitamin C salt or a vitamin C stereoisomer, which has the effect of increasing the absorption rate of iron in the small intestine.

根據聯合國糧農組織與世界衛生組織(FAO/WHO)之報告,缺鐵為現代人不可忽視的營養缺乏問題之一,鐵缺乏之問題除了盛行於經濟落後的開發中國家外,在經濟富裕之歐美先進國家也沒有完全解決。缺鐵為一漸進而連續的變化過程,初期為體內儲存之鐵耗盡,使得血液中運送之鐵短缺,而逐漸地不敷造血組織之需要,最後導致血紅素之合成不足,而造成貧血症狀,因此,貧血是缺鐵末期的症狀。According to the report of the Food and Agriculture Organization of the United Nations and the World Health Organization (FAO/WHO), iron deficiency is one of the nutritional deficiencies that modern people cannot ignore. The problem of iron deficiency is not only in the economically backward developing countries, but also in the economically rich Europe and the United States. Advanced countries have not completely resolved. Iron deficiency is a gradual and continuous process of change. At the beginning, the iron stored in the body is depleted, which causes the shortage of iron in the blood, and gradually eliminates the need for hematopoietic tissue, and finally leads to insufficient synthesis of hemoglobin, which causes anemia. Therefore, anemia is a symptom of iron deficiency.

美國自1943年開始強制實行麵粉營養強化措施,添加的營養素包括維生素B1、B2、菸鹼素與鐵,然而根據美國健康調查NHANES III(1988-1994),美國缺鐵盛行率以生育年齡女性有9-11%最高,其次是1-2歲幼兒9%,50歲以上女性也有5-7%之多,男性缺鐵率則低於2%。瑞典之調查指出其青少年之缺鐵盛行率超過15%,女性甚至高達40%,有明顯的性別差異,以女性較男性為嚴重。Since 1943, the United States has imposed mandatory flour fortification measures. The added nutrients include vitamins B1, B2, nicotinicin and iron. However, according to the US Health Survey NHANES III (1988-1994), the prevalence of iron deficiency in the United States is based on women of childbearing age. 9-11% is the highest, followed by 9% for 1-2 years old, 5-7% for women over 50, and less than 2% for men. The Swedish survey pointed out that the prevalence of iron deficiency among young people is over 15%, and women are even as high as 40%. There are obvious gender differences, with women being more serious than men.

根據人體與動物實驗證實,缺鐵會影響人體兩項免疫功能:中性白血球吞噬細菌能力降低以及T淋巴細胞對細胞增生劑或抗原的反應降低。此外,缺鐵還會增加鉛中毒的危險,其原因在於缺鐵時小腸負責鐵吸收的蛋白質DMT1表現增加,但是它缺乏專一性,故對其他二價金屬元素,例如鉛、鉻等重金屬的吸收率也伴隨增高。According to human and animal experiments, iron deficiency affects two immune functions: a decrease in the ability of neutrophils to phagocytose bacteria and a decrease in the response of T lymphocytes to cell proliferation agents or antigens. In addition, iron deficiency increases the risk of lead poisoning. The reason is that the protein DMT1, which is responsible for iron absorption in the small intestine, is increased in iron deficiency, but it lacks specificity, so it absorbs other divalent metal elements such as heavy metals such as lead and chromium. The rate is also accompanied by an increase.

另外,研究亦指出,影響鐵吸收的主要因素包括鐵的化學形式以及鐵的可用率(bioavailability),其中,鐵的化學形式可區分為「血鐵質」(heme iron)與「非血鐵質」(non-heme iron)兩種。「血鐵質」主要來自肉類,其吸收不受其他飲食成分的影響,吸收率平均25%;「非鐵血質」來自各種植物性食品,如鐵蛋白(ferritin)以及鐵補充劑等,其吸收率平均約7.5%。飲食成分會影響「非血鐵質」的吸收率,因此,鐵可用率係代表食物或飲食中可被人體正常消化、吸收並供生理利用的鐵,這是綜合數個生理過程的結果,該些生理過程可分為三個步驟:(1)消化;(2)小腸細胞攝入鐵(iron uptake)與血液運輸;以及(3)形成功能性蛋白質以執行生理功能。此外,許多研究與實驗發現,促進吸收鐵吸收率的成分包括維生素C以及禽、畜、魚貝等動物之肌肉蛋白質,維生素C含量在25-100 mg之間與鐵吸收率有正比關係,當維生素C之添加劑量超過100 mg則無進一步的效益。禽、畜、魚貝等動物之肌肉蛋白質,其消化分解之小分子產物可以與鐵形成可溶性錯合物以增加鐵的溶解度而促進吸收。In addition, the study also pointed out that the main factors affecting iron absorption include the chemical form of iron and the availability of iron (bioavailability). Among them, the chemical form of iron can be divided into "heme iron" and "non-blood iron". (non-heme iron) two kinds. "Blood iron" is mainly derived from meat. Its absorption is not affected by other dietary ingredients. The absorption rate is 25% on average. "Non-Jewish blood quality" comes from various plant foods, such as ferritin and iron supplements. The average rate is about 7.5%. Dietary ingredients can affect the absorption rate of "non-blood iron". Therefore, iron availability is the result of iron that is normally digested, absorbed, and used by the body in food or diet. This is the result of a combination of several physiological processes. These physiological processes can be divided into three steps: (1) digestion; (2) iron uptake and blood transport by small intestine cells; and (3) formation of functional proteins to perform physiological functions. In addition, many studies and experiments have found that the ingredients that promote the absorption of iron include vitamin C and the muscle protein of animals such as poultry, livestock, and fish. The vitamin C content is between 25-100 mg and has a proportional relationship with the iron absorption rate. There is no further benefit if the amount of vitamin C additive exceeds 100 mg. The muscle protein of animals such as poultry, livestock, and fish, which is digested and decomposed by small molecules, can form a soluble complex with iron to increase the solubility of iron and promote absorption.

在人類的日常生活中,豆奶為常見的飲品之一,亦被稱為豆漿。豆奶係一種以黃豆(或黑豆)為原料而製成之飲品,其簡易之製作方法如下:(1)將黃豆放在水中浸泡約3至8個小時,黃豆泡發後呈橢球狀;(2)將黃豆磨碎或用粉碎機打碎,並用紗布將豆渣分離,以得到生豆奶;以及(3)將水加入生豆奶之中,並煮沸生豆奶持續5至10分鐘。由於生豆奶具有會引發過敏的黃豆皂鹼,引此,由黃豆渣所獲得之生豆奶必須加以煮沸,以破壞會引發過敏的黃豆皂鹼,如此,食用豆奶才不會引發過敏。Soymilk is one of the most common drinks in human life, also known as soy milk. Soymilk is a kind of beverage made from soybean (or black bean). The simple method is as follows: (1) Soak the soybean in water for about 3 to 8 hours, and the soybean is ellipsoid after foaming; 2) The soybeans are ground or broken with a pulverizer, and the bean dregs are separated by gauze to obtain raw soy milk; and (3) water is added to the raw soy milk, and the raw soy milk is boiled for 5 to 10 minutes. Since raw soy milk has soy saponin which causes allergies, the raw soy milk obtained from the soybean dregs must be boiled to destroy the soy saponin which causes allergies, so that eating soy milk does not cause allergies.

豆奶極富營養和保健價值,富含蛋白質和鈣、磷、鐵、鋅等幾十種礦物質以及維他命A、維他命B等多種維生素;此外,豆奶的蛋白質含量比牛奶還要高,係價廉物美的蛋白質來源;並且,豆奶之中更含有大豆皂甙、異黃酮、卵磷脂等有防癌健腦意義的特殊保健因子;再者,豆奶亦不含乳糖,故對於具有乳糖不耐症之人不會產生副作用。有鑒於豆奶所富有之高度營養價值,學者認為,適當的飲用豆奶能夠防止衰老、糖尿病、高血壓、冠心病、癌症、腦中風、支氣管炎、老年癡呆、便祕、肥胖等疾病,而達到強身健體之功效。Soymilk is rich in nutrients and health benefits. It is rich in protein and dozens of minerals such as calcium, phosphorus, iron and zinc, as well as vitamins such as vitamin A and vitamin B. In addition, the protein content of soy milk is higher than that of milk. The protein source of Wumei; and, soy milk contains soy saponins, isoflavones, lecithin and other special health care factors that have anti-cancer and brain-inducing significance; in addition, soy milk does not contain lactose, so for people with lactose intolerance No side effects. In view of the high nutritional value of soy milk, scholars believe that proper consumption of soy milk can prevent aging, diabetes, high blood pressure, coronary heart disease, cancer, stroke, bronchitis, senile dementia, constipation, obesity and other diseases, and achieve physical fitness. The effect of the body.

然而,豆奶雖具有豐富的營養成分,但也含有大量的草酸與植酸,這兩種物質容易與鐵離子螯合,形成不溶性的草酸亞鐵與植酸鐵沉澱,大幅降低人體對鐵的吸收,故,長期飲用豆奶者,有可能會因鐵質吸收被抑制而造成缺鐵性貧血。However, although soy milk is rich in nutrients, it also contains a large amount of oxalic acid and phytic acid. These two substances are easily chelated with iron ions to form insoluble ferrous oxalate and iron phytate precipitate, which greatly reduces the body's absorption of iron. Therefore, long-term consumption of soy milk may cause iron deficiency anemia due to inhibition of iron absorption.

因此,有鑒於飲用豆奶具有強身健體之輔助功效以及鐵為人體所不可或缺之營養,本案之發明人係極力加以研究,冀望研發出不會對人體鐵吸收率造成影響之豆奶飲品,經過多次的實驗驗證,最終,本案之發明人提出一種添加維生素C、維生素C鹽類或維生素C立體異構物之豆奶。Therefore, in view of the fact that drinking soy milk has the auxiliary effect of strengthening the body and the nutrients that iron is indispensable for the human body, the inventors of this case tried to study and hope to develop soy milk drinks that would not affect the body's iron absorption rate. Many experiments have verified that, finally, the inventor of the present invention proposed a soy milk supplemented with vitamin C, vitamin C salt or vitamin C stereoisomer.

本發明之主要目的,在於提供一種添加維生素C之豆奶,使得人們飲用該添加維生素C之豆奶後,會因為抗壞血酸所解離出的抗壞血酸離子之作用,而避免發生體內鐵可用率被抑制之現象,進一步地,更可增加小腸對鐵的吸收率。The main object of the present invention is to provide a soy milk supplemented with vitamin C, so that after drinking the added soy milk of the vitamin C, the ascorbic acid ions which are separated by the ascorbic acid can be prevented, and the iron availability rate in the body is prevented from being inhibited. Further, the absorption rate of iron in the small intestine can be increased.

因此,為了達成本發明之主要目的,本案之發明人係提出一種添加維生素C之豆奶,係藉由添加抗壞血酸(ascorbic acid)於以至少一豆類為製造原料的飲品內而製成,可增加小腸對鐵的吸收率,其中,抗壞血酸之添加劑量為25~50 mg/100mL。Therefore, in order to achieve the main object of the present invention, the inventors of the present invention have proposed a soy milk supplemented with vitamin C, which is prepared by adding ascorbic acid to a beverage made of at least one legume, which can increase the small intestine. The absorption rate of iron, wherein the amount of ascorbic acid additive is 25 to 50 mg/100 mL.

本發明之另一目的,在於提供一種添加維生素C鹽類之豆奶,使得人們飲用該添加維生素C鹽類之豆奶後,會因為抗壞血酸鹽所解離出的抗壞血酸離子之作用,而避免發生體內鐵可用率被抑制之現象,進一步地,更可增加小腸對鐵的吸收率。Another object of the present invention is to provide a soy milk which is added with vitamin C salt, so that after drinking the added soy C salt soy milk, the iron in the body can be avoided due to the action of ascorbate ions which are dissociated by ascorbate. The rate is suppressed, and further, the absorption rate of iron in the small intestine can be increased.

為了達成本發明之另一目的,本案之發明人係提出一種添加維生素C鹽類之豆奶,係藉由添加一抗壞血酸鹽(ascorbate)於以至少一豆類為製造原料的一飲品內而製成,可增加小腸對鐵的吸收率,其中,該抗壞血酸鹽所貢獻之抗壞血酸離子之劑量為25~50 mg/100mL。In order to achieve another object of the present invention, the inventors of the present invention have proposed a soy milk supplemented with vitamin C salt by adding an ascorbate to a beverage made of at least one legume. It can increase the absorption rate of iron in the small intestine, wherein the ascorbate ion dose of the ascorbate is 25-50 mg/100 mL.

本發明之再一目的,在於提供一種添加維生素C立體異構物之豆奶,使得人們飲用該添加維生素C立體異構物之豆奶後,會因為抗壞血酸之立體異構物所解離出的抗壞血酸離子之作用,而避免發生體內鐵可用率被抑制之現象,進一步地,更可增加小腸對鐵的吸收率。A further object of the present invention is to provide a soy milk supplemented with a stereoisomer of vitamin C, such that the ascorbic acid ion which is dissociated by the stereoisomer of ascorbic acid after drinking the soy milk added with the stereoisomer of vitamin C The effect is to avoid the phenomenon that the iron availability rate in the body is suppressed, and further, the absorption rate of iron in the small intestine can be increased.

為了達成本發明之再一目的,本案之發明人係提出一種添加維生素C立體異構物之豆奶,係藉由添加一抗壞血酸(ascorbate)之立體異構物(stereoisomer)於以至少一豆類為製造原料的一飲品內而製成,可增加小腸對鐵的吸收率,其中,該抗壞血酸之立體異構物所貢獻之抗壞血酸離子之劑量為25~50 mg/100mL。In order to achieve a further object of the present invention, the inventors of the present invention have proposed a soy milk supplemented with a stereoisomer of vitamin C by adding a stereoisomer of ascorbate to at least one legume. The raw material is made in a drink, which can increase the absorption rate of iron in the small intestine, wherein the dose of the ascorbic acid ion contributed by the stereoisomer of the ascorbic acid is 25-50 mg/100 mL.

為了能夠更清楚地描述本發明所提出之一種添加維生素C、維生素C鹽類或維生素C立體異構物之豆奶,以下將配合圖示,並透過實驗,以詳盡說明本發明之實施例。In order to more clearly describe a soy milk supplemented with vitamin C, vitamin C salt or vitamin C stereoisomer proposed by the present invention, the embodiments of the present invention will be described in detail below with reference to the drawings.

豆奶為人們日常生活之中所常見的飲品之一,因此,可想而知,人們必定經常飲用豆奶。然而,研究發現,豆奶雖具有豐富的營養成分但也含有大量的草酸與植酸,其中,草酸與植酸這兩種物質係容易與鐵離子螯合,而形成不溶性的草酸亞鐵與植酸鐵沉澱,導致人體對鐵的吸收率之下降,因此,長期飲用豆奶之人係極有可能會因為鐵吸收率被抑制之故,而造成缺鐵性貧血。Soymilk is one of the most common drinks in people's daily lives. Therefore, it is conceivable that people must drink soy milk regularly. However, the study found that although soy milk is rich in nutrients, it also contains a large amount of oxalic acid and phytic acid. Among them, oxalic acid and phytic acid are easily chelated with iron ions to form insoluble ferrous oxalate and phytic acid. Iron precipitation causes the body's absorption rate of iron to drop. Therefore, people who drink soy milk for a long time are likely to cause iron deficiency anemia because the iron absorption rate is suppressed.

此外,研究亦指出,人體適量地攝取維生素C會促進小腸對鐵的吸收率,其原因為維生素C能降低抑制物質(例如:草酸與植酸)與鐵的結合力,使得鐵離子在小腸中更容易釋放成水溶性的形式,並被人體所吸收(請見參考文獻1:Hallberg L,Brune M,Rossander-Hulthn L(1987). Is there a physiological role of vitamin C in iron absorption?Ann N Y Acad Sci.,498:324-32,以及參考文獻2:Hunt JR,Mullen LM,Lykken GI,Gallagher SK,Nielsen FH(1990). Ascorbic acid: effect on ongoing iron absorption and status in iron-depleted young women. Am J Clin Nutr. Apr;51(4):649-55)。於此,必須特別說明的是,維生素C除了最常見的酸式抗壞血酸以及經中和後產生的抗壞血酸鹽,例如,抗壞血酸鈉、抗壞血酸鈣、抗壞血酸鉀、以及抗壞血鎂等;維生素C存在有人工合成的維生素C之立體異構物,即,異抗壞血酸。In addition, the study also pointed out that the proper intake of vitamin C in the human body will promote the absorption of iron in the small intestine. The reason is that vitamin C can reduce the binding of inhibitory substances (such as oxalic acid and phytic acid) to iron, making iron ions in the small intestine. It is more easily released into a water-soluble form and is absorbed by the body (see Reference 1: Hallberg L, Brune M, Rossander-Hulth) n L (1987). Is there a physiological role of vitamin C in iron absorption? Ann NY Acad Sci., 498:324-32, and reference 2: Hunt JR, Mullen LM, Lykken GI, Gallagher SK, Nielsen FH ( 1990). Ascorbic acid: effect on ongoing iron absorption and status in iron-depleted young women. Am J Clin Nutr. Apr; 51(4): 649-55). Here, it must be specifically stated that vitamin C has the most common acid ascorbic acid and ascorbate produced after neutralization, for example, sodium ascorbate, calcium ascorbate, potassium ascorbate, and ascorbate; A synthetic stereoisomer of vitamin C, i.e., erythorbic acid.

承上述,為了使得經常飲用豆奶的人們可以免除罹患缺鐵性貧血之疑慮,且可繼續其飲用豆奶之習慣,本發明係藉由將一抗壞血酸(ascorbic acid)添加於以至少一豆類為製造原料的一飲品內,而製成一種添加維生素C之豆奶,其中,該添加維生素C之豆奶可增加小腸對鐵的吸收率,且該抗壞血酸之添加劑量為25~50 mg/100mL。此外,必須特別說明的是,由於抗壞血酸(即,維生素C)可取製於天然食物亦可透過化學合成之方式製成,故,對於添加於該以豆類為製造原料之飲品之抗壞血酸而言,並不限定為天然取得之抗壞血酸或化學合成之抗壞血酸;另外,由於黃豆與黑豆皆可用以製成豆奶,故該豆類之原料可不限定為黃豆或黑豆。In view of the above, in order to make people who regularly drink soy milk can avoid the fear of suffering from iron deficiency anemia, and can continue their habit of drinking soy milk, the present invention is to add at least one bean as raw material by adding ascorbic acid. In a drink, a soy milk supplemented with vitamin C is prepared, wherein the soy milk added with vitamin C can increase the absorption rate of iron in the small intestine, and the amount of the ascorbic acid additive is 25-50 mg/100 mL. In addition, it must be particularly noted that since ascorbic acid (ie, vitamin C) can be prepared from natural foods by chemical synthesis, it is added to the ascorbic acid added to the beverage in which the beans are used as raw materials for production. It is not limited to naturally occurring ascorbic acid or chemically synthesized ascorbic acid; in addition, since both soybeans and black beans can be used to make soy milk, the raw materials of the beans are not limited to soybeans or black beans.

另外,由於維生素C具有多種型式,因此,根據維生素C之不同型式,於本發明之中,亦藉由將一抗壞血酸鹽(ascorbate)添加於以至少一豆類為製造原料的一飲品內,而製成一種添加維生素C鹽類之豆奶。其中,同樣地,該添加維生素C鹽類之豆奶可增加小腸對鐵的吸收率,且該抗壞血酸鹽所貢獻之抗壞血酸離子之劑量為25~50 mg/100mL。對於該添加維生素C鹽類之豆奶而言,抗壞血酸鹽可為抗壞血酸鈣(Calcium Ascorbate)、抗壞血酸鈉(Sodium Ascorbate)、抗壞血酸鋅(Zinc Ascorbate)、與抗壞血酸鉀(Potassium Ascorbate);當然,如同前述本發明之添加維生素C之豆奶,對於該添加維生素C鹽類之豆奶而言,並不限定其抗壞血酸鹽必須為天然取得之抗壞血酸鹽或者化學合成之抗壞血酸鹽。In addition, since vitamin C has various types, according to different types of vitamin C, in the present invention, by adding ascorbate to a beverage made of at least one legume, It is a kind of soy milk with vitamin C salt added. Among them, the soy milk added with vitamin C salt can increase the absorption rate of iron in the small intestine, and the dose of ascorbate ion contributed by the ascorbate is 25-50 mg/100 mL. For the soy milk added with vitamin C salt, the ascorbate may be Calcium Ascorbate, Sodium Ascorbate, Zinc Ascorbate, and Potassium Ascorbate; of course, as described above In the soybean milk to which the vitamin C is added, the ascorbate to be added to the vitamin C salt is not limited to the ascorbate or the chemically synthesized ascorbate which is naturally obtained.

再者,根據維生素C之不同型式,於本發明之中,又藉由將一抗壞血酸(ascorbate)之立體異構物(stereoisomer)添加於以至少一豆類為製造原料的一飲品內,而製成一種一種添加維生素C立體異構物之豆奶之豆奶,其中,該添加維生素C立體異構物之豆奶亦可增加小腸對鐵的吸收率,且該抗壞血酸之立體異構物所貢獻之抗壞血酸離子之劑量為25~50 mg/100mL。並且,添加於該豆類飲品內的該抗壞血酸立體異構物可為下列任一種:異抗壞血酸(Erythorbic Acid)、異抗壞血酸鈣(Calcium Erythorbate)、異抗壞血酸鈉(Sodium Erythorbate)、異抗壞血酸鋅(zinc Erythorbate)、與異抗壞血酸鉀(Potassium Erythorbate)。Further, according to different types of vitamin C, in the present invention, by adding a stereoisomer of ascorbate (stereoisomer) to a beverage made of at least one legume, Soymilk of soy milk supplemented with a stereoisomer of vitamin C, wherein the soybean milk added with the stereoisomer of vitamin C can also increase the absorption rate of iron in the small intestine, and the ascorbic acid ion contributed by the stereoisomer of ascorbic acid The dose is 25~50 mg/100mL. Further, the ascorbic acid stereoisomer added to the legume may be any of the following: Erythorbic Acid, Calcium Erythorbate, Sodium Erythorbate, zinc Erythorbate ), with Potassium Erythorbate.

如此,經由上述,本發明所提出之添加維生素C、維生素C鹽類或維生素C立體異構物之豆奶,係已清楚地被描述及揭露。接著,為了證明人體飲用該添加維生素C、維生素C鹽類或維生素C立體異構物之豆奶之後,的確可提升體內鐵的可用率,以下將透過多組實驗加以證明此一事實。其中,實驗所採用的分析方法為「體外消化透析法(in vitro digestion and dialysis)」,此方法為測定經模擬人體胃液、腸液消化過的食物所釋放之鐵離子,以可釋放鐵作為人體可吸收鐵的指標。Thus, through the above, the soy milk added with the vitamin C, vitamin C salt or vitamin C stereoisomer proposed by the present invention has been clearly described and disclosed. Then, in order to prove that the human body drinking the soy milk supplemented with vitamin C, vitamin C salt or vitamin C stereoisomers, it can indeed increase the availability of iron in the body. The following will prove this fact through multiple experiments. Among them, the analysis method used in the experiment is "in vitro digestion and dialysis", which is to measure iron ions released from foods that have been digested by human gastric juice and intestinal juice, and to release iron as human body. An indicator of iron absorption.

首先,實驗係採用硫酸亞鐵七水合物作為標準品,並將硫酸亞鐵七水合物之水溶液進行體外消化透析處理,並測定經消化後硫酸亞鐵水溶液的可透析鐵。結果顯示,鐵離子濃度為100 ppm的硫酸亞鐵水溶液經胃液和腸液作用後,僅剩下50.39%的鐵離子可被釋放,這表示,人體腸胃會自然地抑制49.61%的鐵,使得人體攝取的鐵無法全部被釋放與吸收。First, the experiment used ferrous sulfate heptahydrate as a standard, and an aqueous solution of ferrous sulfate heptahydrate was subjected to in vitro digestion and dialysis treatment, and dialysis iron of dihydrated ferrous sulfate aqueous solution was measured. The results showed that only 50.39% of the iron ions could be released after the aqueous solution of iron sulphate with a concentration of 100 ppm of iron sulphate was released by gastric juice and intestinal juice, which means that the human stomach naturally inhibits 49.61% of iron, making the body ingest. The iron cannot be completely released and absorbed.

另外,根據美國農業部(United States Department of Agriculture,USDA)的資料庫,可以得知豆奶的總鐵含量約為每一百公克0.4 mg(即4 ppm),但是體外消化透析測試的結果完全無法偵測到可釋放鐵,這代表人們飲用豆奶之後,除了腸胃道的自然抑制之外,豆奶中的成份也會抑制鐵離子釋放,使得豆奶所含的鐵無法完全釋放給人體吸收。In addition, according to the United States Department of Agriculture (USDA) database, it can be known that the total iron content of soy milk is about 0.4 mg per 100 grams (4 ppm), but the results of the in vitro digestion and dialysis test are completely impossible. The detection of releasable iron means that after drinking soy milk, in addition to the natural inhibition of the gastrointestinal tract, the ingredients in the soy milk also inhibit the release of iron ions, so that the iron contained in the soy milk can not be completely released to the body.

為了改善此一抑制現象,本發明進行了第一個實驗,即,將抗壞血酸與抗壞血酸鈉分別加入豆奶之中,並測定豆奶經體外消化透析處理後的可釋放鐵。請參閱下列表(一),係豆奶經體外消化透析處理後的可釋放鐵之統計表。In order to improve this inhibition phenomenon, the present invention conducted a first experiment in which ascorbic acid and sodium ascorbate were separately added to soybean milk, and the releaseable iron of the soybean milk after in vitro digestion and dialysis treatment was measured. Please refer to the following list (1) for the statistics of the releasable iron after soymilk digestion in vitro.

表(一)豆奶經體外消化透析處理後的可釋放鐵之統計表Table (1) Statistical Table of Releasable Iron after Soymilk Is Digested by In Vitro Digestion

*相對釋放率=(鐵釋放率)/(硫酸亞鐵水溶液之鐵釋放率)* Relative release rate = (iron release rate) / (iron release rate of aqueous ferrous sulfate solution)

如上述表(一)所示,添加抗壞血酸和抗壞血酸鈉於豆奶內,可明顯降低豆奶對鐵釋放的抑制力,使鐵離子能釋放到消化液中;若添加更高劑量的抗壞血酸,則可讓原本會被腸胃液抑制而無法釋放的鐵也釋放出來,因此,經由實驗證明,抗壞血酸和抗壞血酸鈉能促進豆奶中鐵的釋放。As shown in Table (1) above, the addition of ascorbic acid and sodium ascorbate in soy milk can significantly reduce the inhibition of iron release by soy milk, so that iron ions can be released into the digestive juice; if a higher dose of ascorbic acid is added, it can be Iron, which was originally inhibited by the gastrointestinal fluid and could not be released, was also released. Therefore, it has been experimentally proven that ascorbic acid and sodium ascorbate can promote the release of iron from soybean milk.

為了更進一步地證明添加抗壞血酸、抗壞血酸鹽、或抗壞血酸立體異構物於豆奶內,係的確可增強豆奶的鐵釋放率,於本發明之中,又進行了第二個實驗,即,將硫酸亞鐵七水合物、甘胺酸亞鐵、焦磷酸鐵、以及葡萄糖酸鐵分別加入豆奶之中,並測定豆奶經體外消化透析處理後的可釋放鐵。接著,將上述四種鐵依不同的鐵濃度梯度添加至豆奶中,測定其經體外消化透析後的自然釋放率,並以可釋放鐵濃度恰開始隨添加量增加而上升的點為基準,將該添加量視為對相對應鐵劑在豆奶中開始明顯被大量抑制的濃度(即,抑制起始濃度),其實驗之結果整理如下表(二)。In order to further prove that the addition of ascorbic acid, ascorbate or ascorbate stereoisomer in soy milk, the system can indeed enhance the iron release rate of soybean milk. In the present invention, a second experiment is carried out, that is, sulfuric acid Iron heptahydrate, ferrous glycinate, iron pyrophosphate, and iron gluconate were separately added to the soy milk, and the releaseable iron of the soy milk after in vitro digestion and dialysis treatment was measured. Next, the above four irons are added to the soy milk according to different iron concentration gradients, and the natural release rate after in vitro digestion and dialysis is measured, and based on the point at which the releaseable iron concentration just starts to increase with the increase of the added amount, The addition amount was regarded as a concentration at which the corresponding iron agent began to be significantly inhibited in the soybean milk (i.e., the initial concentration was suppressed), and the results of the experiment were summarized in the following Table (2).

表(二)添加不同鐵劑之豆奶的可釋放鐵濃度之統計表Table (2) Statistical Table of Releasable Iron Concentration of Soymilk with Different Irons

*數值標示粗體者表示為抑制起始濃度*The value indicates the boldness is expressed as the inhibition of the initial concentration.

請參閱第一圖,係鐵劑添加量與豆奶可釋放鐵濃度之關係曲線圖,其中,如上述表(二)與第一圖所示,吾人可以得知硫酸亞鐵、甘胺酸亞鐵、焦磷酸鐵、以及葡萄糖酸鐵之抑制起始濃度分別為20ppm、20ppm、50ppm、以及30ppm。接著,以20ppm硫酸亞鐵、20ppm甘胺酸亞鐵、50ppm焦磷酸鐵、以及30ppm葡萄糖酸鐵為基礎,分別將抗壞血酸(維生素C)以及抗壞血酸鹽添加於添加有20ppm硫酸亞鐵的豆奶之中,並測試硫酸亞鐵豆奶之鐵釋放率,實驗結果係整理於下列表(三)、表(四)、表(五)、表(六)、以及表(七);並且,於表(三)、表(四)、表(五)、表(六)、以及表(七)之中,抗壞血酸係簡稱為VC、抗壞血酸鈉係簡稱為NaVC、抗壞血酸鉀係簡稱為KVC、抗壞血酸鈣係簡稱為CaVC。Please refer to the first figure, which is a graph showing the relationship between the amount of iron added and the concentration of iron released from soybean milk. As shown in Table (2) above and the first figure, we can know ferrous sulfate and ferrous ferrous sulfate. The inhibitory initial concentrations of iron pyrophosphate and iron gluconate were 20 ppm, 20 ppm, 50 ppm, and 30 ppm, respectively. Next, ascorbic acid (vitamin C) and ascorbate were added to soy milk supplemented with 20 ppm of ferrous sulfate, respectively, based on 20 ppm of ferrous sulfate, 20 ppm of ferrous glycinate, 50 ppm of iron pyrophosphate, and 30 ppm of iron gluconate. And testing the iron release rate of ferrous sulfate soy milk, the experimental results are summarized in the following list (three), table (four), table (f), table (six), and table (seven); and, in the table (three , Table (4), Table (5), Table (6), and Table (7), ascorbic acid is abbreviated as VC, sodium ascorbate is abbreviated as NaVC, potassium ascorbate is abbreviated as KVC, and calcium ascorbate is abbreviated as CaVC.

表(三)添加20ppm硫酸亞鐵與抗壞血酸之豆奶的可釋放鐵濃度之統計表Table (3) Statistical Table of Releasable Iron Concentration of Soymilk Adding 20ppm Ferrous Sulfate and Ascorbic Acid

表(四)添加20ppm硫酸亞鐵與抗壞血酸鈉之豆奶的可釋放鐵濃度之統計表Table (4) Statistical Table of Releasable Iron Concentration of Soymilk Adding 20ppm Ferrous Sulfate and Sodium Ascorbate

*其中由抗壞血酸鈉所解離之抗壞血酸離子含量為87.5%*The ascorbic acid ion content dissociated by sodium ascorbate is 87.5%

表(五)添加20ppm硫酸亞鐵與抗壞血酸鉀之豆奶的可釋放鐵濃度之統計表Table (5) Statistical Table of Releasable Iron Concentration of Soymilk Adding 20ppm Ferrous Sulfate and Potassium Ascorbate

*其中由抗壞血酸鉀所解離之抗壞血酸離子含量為82.2%*The amount of ascorbate ion dissociated by potassium ascorbate is 82.2%

表(六)添加20ppm硫酸亞鐵與抗壞血酸鈣之豆奶的可釋放鐵濃度之統計表Table (vi) Statistical Table of Releasable Iron Concentration of Soymilk Adding 20ppm Ferrous Sulfate and Calcium Ascorbate

*其中由抗壞血酸鈣所解離之抗壞血酸離子含量為89.8%* The ascorbic acid ion content dissociated by calcium ascorbate is 89.8%

表(七) 抗壞血酸離子對添加20ppm硫酸亞鐵之豆奶的可釋放鐵濃度之統計表Table (VII) Statistical Table of Ascorbable Acid Ion for Repellent Iron Concentration of Soymilk Adding 20ppm Ferrous Sulfate

請另外參閱第二圖,係抗壞血酸與抗壞血酸鹽對於添加硫酸亞鐵之豆奶的可釋放鐵濃度之關係曲線圖,同時,請另外再參閱第三圖,係硫酸亞鐵豆奶添加不同抗壞血酸鹽類但具有相同抗壞血酸離子濃度時的平均可釋放鐵濃度之曲線圖。如上述表(三)、表(四)、表(五)、表(六)、以及表(七)、第二圖、以及第三圖所示,可以得知,對於添加硫酸亞鐵之豆奶而言,基本上,其可釋放鐵濃度係隨著抗壞血酸或抗壞血酸鹽之添加量而增加,並且,當抗壞血酸或抗壞血酸鹽之添加量達到一定的量時,添加硫酸亞鐵之豆奶的可釋放鐵濃度便不會再有顯著的上升。Please also refer to the second figure, which is a graph showing the relationship between the concentration of ascorbic acid and ascorbate on the releasable iron concentration of soy milk added with ferrous sulfate. Please also refer to the third figure for the addition of different ascorbate to ferrous sulfate soy milk. A graph of the average releasable iron concentration with the same ascorbate ion concentration. As shown in Table (3), Table (4), Table (5), Table (6), and Table (7), Figure 2, and Figure 3 above, it can be known that soy milk added with ferrous sulfate In general, the releaseable iron concentration is increased with the addition amount of ascorbic acid or ascorbate, and when the amount of ascorbic acid or ascorbate added reaches a certain amount, the releasable iron of the ferrous sulfate-added soy milk is added. There will be no significant increase in concentration.

繼續地,分別將抗壞血酸以及抗壞血酸鹽添加於添加有20ppm甘胺酸亞鐵的豆奶之中,並測試甘胺酸亞鐵豆奶之鐵釋放率,實驗結果係整理於下列表(八)、表(九)、表(十)、表(十一)、以及表(十二)。Continuingly, ascorbic acid and ascorbate were separately added to soy milk supplemented with 20 ppm of ferrous ferrous sulphate, and the iron release rate of ferrous melamine soy milk was tested. The experimental results were summarized in the following table (8), table ( IX), Table (10), Table (11), and Table (12).

表(八)添加20ppm甘胺酸亞鐵與抗壞血酸之豆奶的可釋放鐵濃度之統計表Table (8) Statistical Table of Releasable Iron Concentration of Soymilk Adding 20ppm Ferrous Glycolate and Ascorbic Acid

表(九)添加20ppm甘胺酸亞鐵與抗壞血酸鈉之豆奶的可釋放鐵濃度之統計表Table (9) Statistical Table of Releasable Iron Concentration of Soymilk Adding 20ppm Ferrous Glycolate and Sodium Ascorbate

*其中由抗壞血酸鈉所解離之抗壞血酸離子含量為87.5%*The ascorbic acid ion content dissociated by sodium ascorbate is 87.5%

表(十)添加20ppm甘胺酸亞鐵與抗壞血酸鉀之豆奶的可釋放鐵濃度之統計表Table (10) Statistical Table of Releasable Iron Concentration of Soymilk Adding 20ppm Ferrous Glycolate and Potassium Ascorbate

*其中由抗壞血酸鉀所解離之抗壞血酸離子含量為82.2%*The amount of ascorbate ion dissociated by potassium ascorbate is 82.2%

表(十一)添加20ppm甘胺酸亞鐵與抗壞血酸鈣之豆奶的可釋放鐵濃度之統計表Table (11) Statistical Table of Releasable Iron Concentration of Soymilk Adding 20ppm Ferrous Glycolate and Calcium Ascorbate

*其中由抗壞血酸鈣所解離之抗壞血酸離子含量為89.8%* The ascorbic acid ion content dissociated by calcium ascorbate is 89.8%

表(十二) 抗壞血酸離子對添加20ppm甘胺酸亞鐵之豆奶的可釋放鐵濃度之統計表Table (12) Statistical table of the releaseable iron concentration of ascorbate ion on soybean milk supplemented with 20 ppm of ferrous ferrous citrate

請另外參閱第四圖,係抗壞血酸與抗壞血酸鹽對於添加甘胺酸亞鐵之豆奶的可釋放鐵濃度之關係曲線圖,同時,請另外再參閱第五圖,係甘胺酸亞鐵豆奶添加不同抗壞血酸鹽類但具有相同抗壞血酸離子濃度時的平均可釋放鐵濃度之曲線圖。如上述表(八)、表(九)、表(十)、表(十一)、以及表(十二)、第四圖、以及第五圖所示,可以得知,對於添加甘胺酸亞鐵之豆奶而言,基本上,其可釋放鐵濃度係隨著抗壞血酸或抗壞血酸鹽之添加量而增加,並且,當抗壞血酸或抗壞血酸鹽之添加量達到一定的量時,添加甘胺酸亞鐵之豆奶的可釋放鐵濃度便不會再有顯著的上升。Please also refer to the fourth figure, which is a graph showing the relationship between the concentration of ascorbic acid and ascorbate on the releasable iron concentration of soy milk added with ferrous ferrous citrate. Please also refer to the fifth figure, which is different from the ferrous succinate milk. A graph of the average releasable iron concentration for ascorbate but with the same ascorbate ion concentration. As shown in Table (8), Table (9), Table (10), Table (11), and Table (12), 4th, and 5th, it can be known that for the addition of glycine In the case of ferrous soy milk, basically, the releaseable iron concentration increases with the addition amount of ascorbic acid or ascorbate, and when the amount of ascorbic acid or ascorbate added reaches a certain amount, ferrous glycinate is added. The concentration of releasable iron in soy milk will no longer increase significantly.

繼續地,分別將抗壞血酸以及抗壞血酸鹽添加於添加有50ppm焦磷酸鐵的豆奶之中,並測試焦磷酸鐵豆奶之鐵釋放率,實驗結果係整理於下列表(十三)、表(十四)、表(十五)、表(十六)、以及表(十七)。Continued, ascorbic acid and ascorbate were added to the soy milk supplemented with 50ppm iron pyrophosphate, and the iron release rate of iron pyrophosphate soy milk was tested. The experimental results are summarized in the following list (13) and Table (14). , Table (15), Table (16), and Table (17).

表(十三)添加50ppm焦磷酸鐵與抗壞血酸之豆奶的可釋放鐵濃度之統計表Table (13) Statistical Table of Releasable Iron Concentration of Soymilk Adding 50ppm Iron Pyrophosphate and Ascorbic Acid

表(十四)添加50ppm焦磷酸鐵與抗壞血酸鈉之豆奶的可釋放鐵濃度之統計表Table (14) Statistical Table of Releasable Iron Concentration of Soymilk Adding 50ppm Iron Pyrophosphate and Sodium Ascorbate

*其中由抗壞血酸鈉所解離之抗壞血酸離子含量為87.5%*The ascorbic acid ion content dissociated by sodium ascorbate is 87.5%

表(十五)添加50ppm焦磷酸鐵與抗壞血酸鉀之豆奶的可釋放鐵濃度之統計表Table (15) Statistical Table of Releasable Iron Concentration of Soymilk Adding 50ppm Iron Pyrophosphate and Potassium Ascorbate

*其中由抗壞血酸鉀所解離之抗壞血酸離子含量為82.2%*The amount of ascorbate ion dissociated by potassium ascorbate is 82.2%

表(十六)添加50ppm焦磷酸鐵與抗壞血酸鈣之豆奶的可釋放鐵濃度之統計表Table (16) Statistical Table of Releasable Iron Concentration of Soymilk Adding 50ppm Iron Pyrophosphate and Calcium Ascorbate

*其中由抗壞血酸鈣所解離之抗壞血酸離子含量為89.8%* The ascorbic acid ion content dissociated by calcium ascorbate is 89.8%

表(十七) 抗壞血酸離子對添加50ppm焦磷酸鐵之豆奶的可釋放鐵濃度之統計表Table (17) Statistical table of the releaseable iron concentration of ascorbate ion on soybean milk supplemented with 50ppm iron pyrophosphate

請另外參閱第六圖,係抗壞血酸與抗壞血酸鹽對於添加焦磷酸鐵之豆奶的可釋放鐵濃度之關係曲線圖,同時,請另外再參閱第七圖,係焦磷酸鐵豆奶添加不同抗壞血酸鹽類但具有相同抗壞血酸離子濃度時的平均可釋放鐵濃度之曲線圖。如上述表(十三)、表(十四)、表(十五)、表(十六)、以及表(十七)、第六圖、以及第七圖所示,可以得知,對於添加焦磷酸鐵之豆奶而言,基本上,其可釋放鐵濃度係隨著抗壞血酸或抗壞血酸鹽之添加量而增加,並且,當抗壞血酸或抗壞血酸鹽之添加量達到一定的量時,添加焦磷酸鐵之豆奶的可釋放鐵濃度便不會再有顯著的上升。Please also refer to the sixth figure, which is a graph showing the relationship between the concentration of ascorbic acid and ascorbate on the releasable iron concentration of soy milk added with iron pyrophosphate. Please also refer to the seventh figure, which is the addition of different ascorbate to the iron pyrophosphate soy milk. A graph of the average releasable iron concentration with the same ascorbate ion concentration. As shown in the above table (13), Table (14), Table (15), Table (16), and Table (17), 6th, and 7th, it can be known that for adding In the case of soy milk of iron pyrophosphate, basically, the releaseable iron concentration increases with the addition amount of ascorbic acid or ascorbate, and when the amount of ascorbic acid or ascorbate added reaches a certain amount, iron pyrophosphate is added. The releasable iron concentration of soy milk will no longer increase significantly.

繼續地,分別將抗壞血酸以及抗壞血酸鹽添加於添加有30ppm葡萄糖酸鐵的豆奶之中,並測試葡萄糖酸鐵鐵豆奶之鐵釋放率,實驗結果係整理於下列表(十八)、表(十九)、表(二十)、表(二十一)、以及表(二十二)。Continued, ascorbic acid and ascorbate were added to the soy milk supplemented with 30ppm iron gluconate, respectively, and the iron release rate of ferric acid iron soy milk was tested. The experimental results are summarized in the following list (18), Table (19 ), Table (20), Table (21), and Table (22).

表(十八)添加30ppm葡萄糖酸鐵與抗壞血酸之豆奶的可釋放鐵濃度之統計表Table (18) Statistical Table of Releasable Iron Concentration of Soymilk Adding 30ppm Iron Glucolate and Ascorbic Acid

表(十九)添加30ppm葡萄糖酸鐵與抗壞血酸鈉之豆奶的可釋放鐵濃度之統計表Table (19) Statistical Table of Releasable Iron Concentration of Soymilk Adding 30ppm Iron Glucolate and Sodium Ascorbate

*其中由抗壞血酸鈉所解離之抗壞血酸離子含量為87.5%*The ascorbic acid ion content dissociated by sodium ascorbate is 87.5%

表(二十)添加30ppm葡萄糖酸鐵與抗壞血酸鉀之豆奶的可釋放鐵濃度之統計表Table (20) Statistical Table of Releasable Iron Concentration of Soymilk Adding 30ppm Iron Glucolate and Potassium Ascorbate

*其中由抗壞血酸鉀所解離之抗壞血酸離子含量為82.2%*The amount of ascorbate ion dissociated by potassium ascorbate is 82.2%

表(二十一)添加30ppm葡萄糖酸鐵與抗壞血酸鈣之豆奶的可釋放鐵濃度之統計表Table (21) Statistical Table of Releasable Iron Concentration of Soymilk Adding 30ppm Iron Glucolate and Calcium Ascorbate

*其中由抗壞血酸鈣所解離之抗壞血酸離子含量為89.8%* The ascorbic acid ion content dissociated by calcium ascorbate is 89.8%

表(二十二) 抗壞血酸離子對添加30ppm葡萄糖酸鐵之豆奶的可釋放鐵濃度之統計表Table (22) Statistical Table of Releasable Iron Concentration of Ascorbic Acid Ion to Soymilk Adding 30ppm Iron Gluconate

表(二十三) 抗壞血酸離子對添加鐵之豆奶的鐵釋放率之統計表Table (23) Statistical Table of Iron Release Rate of Ascorbic Acid Ions to Added Soymilk

請另外參閱第八圖,係抗壞血酸與抗壞血酸鹽對於添加葡萄糖酸鐵之豆奶的可釋放鐵濃度之關係曲線圖,同時,請另外再參閱第九圖,係葡萄糖酸鐵豆奶添加不同抗壞血酸鹽類但具有相同抗壞血酸離子濃度時的平均可釋放鐵濃度之曲線圖。如上述表(十八)、表(十九)、表(二十)、表(二十一)、表(二十二)、表(二十三)、第八圖、以及第九圖所示,可以得知,對於添加葡萄糖酸鐵之豆奶而言,基本上,其可釋放鐵濃度係隨著抗壞血酸或抗壞血酸鹽之添加量而增加,並且,當抗壞血酸或抗壞血酸鹽之添加量達到一定的量時,添加葡萄糖酸鐵之豆奶的可釋放鐵濃度便不會再有顯著的上升。Please also refer to the eighth figure, which is a graph showing the relationship between the concentration of ascorbic acid and ascorbate on the releaseable iron concentration of soy milk added with iron gluconate. At the same time, please refer to the ninth figure, adding different ascorbate to the sour milk gluconate. A graph of the average releasable iron concentration with the same ascorbate ion concentration. As shown in Table (18), Table (19), Table (20), Table (21), Table (22), Table (23), 8th and 9th It can be seen that, for soy milk supplemented with iron gluconate, basically, the releaseable iron concentration increases with the addition amount of ascorbic acid or ascorbate, and when the addition amount of ascorbic acid or ascorbate reaches a certain level At the time of the addition, the releasable iron concentration of the soy milk added with iron gluconate would not increase significantly.

如此,經由上述各種實驗結果,可以得知添加各種鐵劑的豆奶之可釋放鐵濃度,並且,抗壞血酸和抗壞血酸鹽類對各種鐵劑在其抑制起始濃度促進鐵釋放最有效率的添加量及鐵釋放促進率係列於下表(二十四)。Thus, through the various experimental results described above, the releaseable iron concentration of the soy milk to which various iron agents are added can be known, and the ascorbic acid and ascorbate are the most effective addition amounts of the various iron agents to promote the release of iron at the initial concentration thereof. The iron release promotion rate series is shown in the following table (24).

表(二十四) 維生素C離子促進各種鐵劑在豆奶中的鐵釋放率之最有效率劑量與鐵釋放促進率Table (24) Vitamin C ion promotes the most effective dose of iron release rate of iron in soy milk and iron release promotion rate

*其中鐵釋放促進率=(添加抗壞血酸後之可釋放鐵)/(未添加抗壞血酸之可釋放鐵)* Among them, the rate of iron release promotion = (the release of iron after the addition of ascorbic acid) / (the release of iron without the addition of ascorbic acid)

如此,經由上述所列出的實驗資料,吾人可以輕易瞭解維生素C與維生素C鹽類在人體內的確可造成的鐵的釋放率的增加。因此,若以葡萄糖酸鐵作為標準,則維生素C添加於豆奶內較佳的添加量為25~50 mg/100mL。Thus, through the above-listed experimental data, we can easily understand that the vitamin C and vitamin C salts can indeed cause an increase in the release rate of iron in the human body. Therefore, if iron gluconate is used as a standard, the preferred addition amount of vitamin C to soybean milk is 25 to 50 mg/100 mL.

另外,眾所周知,抗壞血酸(維生素C)具有一立體異構物(stereoisomer),名為異抗壞血酸,在物理與化學性質與其相近,但生理功能較低。雖然異抗壞血酸無法被人體的酵素利用,但因其化學性質與抗壞血酸相近,因此,於本發明之中,亦透過實驗結果,而認定抗壞血酸之立體異構物亦具有促進豆奶中鐵離子釋放的功效。實驗過程如下:將異抗壞血酸鈉添加至含有葡萄糖酸鐵26.09 mg/100 mL(鐵添加濃度30 ppm)的豆奶之中,並測定豆奶的可釋放鐵,並且實驗結果整理如下表(二十四)所示。In addition, it is known that ascorbic acid (vitamin C) has a stereoisomer, called isoascorbic acid, which is similar in physical and chemical properties but has a low physiological function. Although erythorbic acid cannot be utilized by human enzymes, its chemical properties are similar to those of ascorbic acid. Therefore, in the present invention, it is also confirmed by experimental results that the stereoisomer of ascorbic acid also promotes the release of iron ions in soybean milk. . The experimental procedure was as follows: sodium erythorbate was added to soybean milk containing 26.09 mg/100 mL of iron gluconate (iron addition concentration of 30 ppm), and the releaseable iron of soybean milk was determined, and the experimental results were summarized as follows (24) Shown.

表(二十四)添加30ppm葡萄糖酸鐵與異抗壞血酸鈉之豆奶的可釋放鐵濃度之統計表Table (24) Statistical Table of Releasable Iron Concentration of Soymilk Adding 30ppm Iron Glucolate and Sodium Ascorbate

請另外參閱第十圖,係異抗壞血酸鈉對於添加葡萄糖酸鐵之豆奶的可釋放鐵濃度之關係曲線圖。如上述表(二十四)以及第十圖所示,可以得知,當豆奶中異抗壞血酸離子添加量與抗壞血酸離子相同時,促進鐵釋放的效果也幾乎一樣。由於異抗壞血酸與抗壞血酸互為光學異構物,當異抗壞血酸或其鹽類(異抗壞血酸鈉、異抗壞血酸鉀、異抗壞血酸鈣、以及異抗壞血酸鋅)溶於水時會解離出帶負電的異抗壞血酸離子,其物理與化學性質與抗壞血酸離子差異不大,故同樣具有促進豆奶中鐵離子釋放的效果。Please also refer to the tenth figure, which is a graph showing the relationship between the releaseable iron concentration of sodium erythorbate and soy milk added with iron gluconate. As shown in the above Tables (24) and 10th, it can be seen that when the amount of erythorbic acid ions added to the soy milk is the same as that of the ascorbic acid ions, the effect of promoting iron release is almost the same. Since erythorbic acid and ascorbic acid are optical isomers, when erythorbic acid or its salts (sodium erythorbate, potassium erythorbate, calcium erythorbate, and zinc erythorbate) are dissolved in water, they will dissociate the negatively-isolated ascorbate ion. Its physical and chemical properties are not much different from ascorbic acid ions, so it also has the effect of promoting the release of iron ions in soy milk.

此外,必須另外說明的是,由於市售之豆奶種類繁多,例如:玄米豆奶、牛奶豆奶、燕麥豆奶、咖啡豆奶、紅茶豆奶、蜜豆奶等,因此,對於本發明之添加維生素C、維生素C鹽類或維生素C立體異構物之豆奶而言,亦可藉由添加玄米、牛奶、咖啡、紅茶、燕麥、雞蛋等物質,使得人們於飲用本發明之添加維生素C、維生素C鹽類或維生素C立體異構物之豆奶之時,除了可增加小腸對鐵的吸收率之外,亦可獲得除了豆奶以外的不同口感,一舉兩得。In addition, it must be additionally stated that, due to the wide variety of commercially available soy milk, for example, black rice soy milk, milk soy milk, oat soy milk, coffee bean milk, black tea soy milk, honey soy milk, etc., therefore, vitamin C and vitamin C salts are added to the present invention. For the soy milk of the stereoisomer of vitamin C or vitamin C, it is also possible to add vitamin C, vitamin C salt or vitamin C to the present invention by adding substances such as black rice, milk, coffee, black tea, oatmeal, eggs and the like. When the soy milk of the stereoisomers can increase the absorption rate of iron in the small intestine, it can also obtain different tastes other than soy milk, and kill two birds with one stone.

另外,本發明所提出的添加維生素C、維生素C鹽類或維生素C立體異構物之豆奶,並不限於以直接將維生素C維生素C鹽類或維生素C立體異構物添加入豆奶之方式達成;實際上,亦可提供調配好之具有維生素C、維生素C鹽類或維生素C立體異構物之一粉末配方予豆奶製造商,再由製造商進行調配,這樣不失為一個製造添加維生素C、維生素C鹽類或維生素C立體異構物之豆奶的方式;其中,該粉末配方之內容物組成係列於下列表(二十五)。In addition, the soy milk added with vitamin C, vitamin C salt or vitamin C stereoisomer proposed by the present invention is not limited to the direct addition of vitamin C vitamin C salt or vitamin C stereoisomer to soybean milk. In fact, it is also possible to provide a powder formula with vitamin C, vitamin C salt or vitamin C stereoisomers to the soy milk manufacturer, and then the manufacturer to mix it, so that it is a manufacturing vitamin C, vitamin The method of soy milk of C salt or vitamin C stereoisomer; wherein the contents of the powder formula are listed in the following list (25).

表(二十五) 添加於豆奶之中的具有維生素C、維生素C鹽類或維生素C立體異構物的粉末配方Table (25) Powder formula with vitamin C, vitamin C salt or vitamin C stereoisomer added to soy milk

如上述表(二十五)所表列,該粉末配方係由多種內容物組合而成,包括:維生素C鈉鹽(NaVC)、乳酸菌、酵母菌、與麥芽糊精,其中,該乳酸菌係採用NTU 101乳酸菌粉,該酵母菌則為超高B群酵母粉。於此,必須特別說明的是,由於粉末配方在進行超高溫滅菌(UHT)時會耗損大約25%維生素C鈉鹽的量,因此,於進行進行超高溫滅菌(UHT)之前,因此,必須事先預添加25%維生素C鈉鹽的量於粉末配方,以作補償。As indicated in the above table (25), the powder formulation is composed of a plurality of contents, including: vitamin C sodium salt (NaVC), lactic acid bacteria, yeast, and maltodextrin, wherein the lactic acid bacteria system NTU 101 lactic acid bacteria powder is used, and the yeast is ultra-high group B yeast powder. Here, it must be particularly noted that since the powder formulation consumes about 25% of the amount of vitamin C sodium salt during ultra-high temperature sterilization (UHT), it is necessary to perform ultra-high temperature sterilization (UHT) beforehand. The amount of 25% vitamin C sodium salt was pre-added to the powder formulation to compensate.

如此,藉由多組實驗數據之佐證,本發明所提出之添加維生素C、維生素C鹽類或維生素C立體異構物之豆奶,係的確可提升人體內鐵的可用率,此外,經由上述,可以得知本發明係具有下列之優點:Thus, the soy milk supplemented with the vitamin C, the vitamin C salt or the vitamin C stereoisomer proposed by the present invention can enhance the availability of iron in the human body by the evidence of a plurality of experimental data. It will be appreciated that the present invention has the following advantages:

1.由於本發明之所提出之添加維生素C、維生素C鹽類或維生素C立體異構物之豆奶可提升人體內鐵的可用率,因此,其可用以替代人們經常飲用的傳統豆奶,使得經常飲用豆奶的人們可以免除罹患缺鐵性貧血之疑慮,且可繼續其飲用豆奶之習慣。1. Since the soy milk added with vitamin C, vitamin C salt or vitamin C stereoisomer proposed by the present invention can increase the availability of iron in the human body, it can be used to replace the traditional soy milk that people often drink, so that often People who drink soy milk can avoid the doubts about iron deficiency anemia and continue their habit of drinking soy milk.

2.本發明之所提出之添加維生素C、維生素C鹽類或維生素C立體異構物之豆奶,可添加玄米、牛奶、咖啡、紅茶、燕麥、雞蛋等物質,使得人們於飲用本發明之豆奶時,除了可增加小腸對鐵的吸收率之外,亦可獲得除了豆奶以外的不同口感,一舉兩得。2. The soy milk added with vitamin C, vitamin C salt or vitamin C stereoisomer proposed in the present invention may add black rice, milk, coffee, black tea, oatmeal, egg and the like, so that people drink the soy milk of the present invention. In addition to increasing the absorption rate of iron in the small intestine, it can also obtain different tastes besides soy milk, killing two birds with one stone.

3.本發明之所提出之添加維生素C、維生素C鹽類或維生素C立體異構物之豆奶,可不限於以直接將維生素C維生素C鹽類或維生素C立體異構物添加入豆奶之方式達成,亦可提供調配好之具有維生素C、維生素C鹽類或維生素C立體異構物之一粉末配方予豆奶製造商,再由製造商調配而得。3. The soy milk added with the vitamin C, the vitamin C salt or the vitamin C stereoisomer proposed by the present invention is not limited to the method of directly adding the vitamin C vitamin C salt or the vitamin C stereoisomer to the soy milk. It can also be supplied with a powder formula of vitamin C, vitamin C salt or vitamin C stereoisomer to the soy milk manufacturer, which is then prepared by the manufacturer.

上述之詳細說明係針對本發明可行實施例之具體說明,惟該實施例並非用以限制本發明之專利範圍,凡未脫離本發明技藝精神所為之等效實施或變更,均應包含於本案之專利範圍中。The detailed description of the present invention is intended to be illustrative of the preferred embodiments of the present invention, and is not intended to limit the scope of the invention. In the scope of patents.

第一圖 係鐵劑添加量與豆奶可釋放鐵濃度之關係曲線圖;The first figure is a graph showing the relationship between the amount of iron added and the concentration of iron that can be released from soybean milk;

第二圖 係抗壞血酸與抗壞血酸鹽對於添加硫酸亞鐵之豆奶的可釋放鐵濃度之關係曲線圖;The second graph is a graph showing the relationship between ascorbic acid and ascorbate for the releaseable iron concentration of soy milk added with ferrous sulfate;

第三圖 係硫酸亞鐵豆奶添加不同抗壞血酸鹽類但具有相同抗壞血酸離子濃度時的平均可釋放鐵濃度之曲線圖;The third figure is a graph of the average releasable iron concentration when ferrous sulfate soy milk is added with different ascorbate but with the same ascorbate ion concentration;

第四圖 係抗壞血酸與抗壞血酸鹽對於添加甘胺酸亞鐵之豆奶的可釋放鐵濃度之關係曲線圖;The fourth graph is a graph showing the relationship between ascorbic acid and ascorbate for the releaseable iron concentration of soy milk added with ferrous ferrous sulfate;

第五圖 係甘胺酸亞鐵豆奶添加不同抗壞血酸鹽類但具有相同抗壞血酸離子濃度時的平均可釋放鐵濃度之曲線圖;Figure 5 is a graph of the average releasable iron concentration when glyceryl glycinate soy milk is added with different ascorbate but with the same ascorbate ion concentration;

第六圖 係抗壞血酸與抗壞血酸鹽對於添加焦磷酸鐵之豆奶的可釋放鐵濃度之關係曲線圖;Figure 6 is a graph showing the relationship between ascorbic acid and ascorbate for the releaseable iron concentration of soy milk added with iron pyrophosphate;

第七圖 係焦磷酸鐵豆奶添加不同抗壞血酸鹽類但具有相同抗壞血酸離子濃度時的平均可釋放鐵濃度之曲線圖;Figure 7 is a graph of the average releasable iron concentration when iron pyrophosphate soy milk is added with different ascorbate but with the same ascorbate ion concentration;

第八圖 係抗壞血酸與抗壞血酸鹽對於添加葡萄糖酸鐵之豆奶的可釋放鐵濃度之關係曲線圖;Figure 8 is a graph showing the relationship between ascorbic acid and ascorbate for the releaseable iron concentration of soy milk added with iron gluconate;

第九圖 係葡萄糖酸鐵豆奶添加不同抗壞血酸鹽類但具有相同抗壞血酸離子濃度時的平均可釋放鐵濃度之曲線圖;以及Figure 9 is a graph of the average releasable iron concentration when iron gluconate soy milk is added with different ascorbate but with the same ascorbate ion concentration;

第十圖 係異抗壞血酸鈉對於添加葡萄糖酸鐵之豆奶的可釋放鐵濃度之關係曲線圖。Figure 10 is a graph showing the relationship between the concentration of repellent iron of soy ascorbate added to soy milk added with iron gluconate.

Claims (18)

一種添加維生素C之豆奶,係藉由添加一抗壞血酸(ascorbic acid)於以至少一豆類為製造原料的一飲品內而製成,可增加小腸對鐵的吸收率,其中,該抗壞血酸之添加劑量為25~50 mg/100mL。The soy milk added with vitamin C is prepared by adding ascorbic acid to a beverage made of at least one legume, which can increase the absorption rate of iron in the small intestine, wherein the amount of the ascorbic acid additive is 25~50 mg/100mL. 如申請專利範圍第1項所述之添加維生素C之豆奶,其中,該抗壞血酸係取製於天然食物。The soy milk added with vitamin C as described in claim 1, wherein the ascorbic acid is taken from a natural food. 如申請專利範圍第1項所述之添加維生素C之豆奶,其中,該抗壞血酸係取製於化學合成。The soy milk added with vitamin C as described in claim 1, wherein the ascorbic acid is chemically synthesized. 如申請專利範圍第1項所述之添加維生素C之豆奶,其中,該豆類可為下列任一種:黃豆與黑豆。The soy milk added with vitamin C as described in claim 1, wherein the beans may be any of the following: soybeans and black beans. 如申請專利範圍第1項所述之添加維生素C之豆奶,可進一步地添加下列任一種添加物:玄米、牛奶、咖啡、紅茶、燕麥、雞蛋。As the soy milk added with vitamin C as described in the first aspect of the patent application, any of the following additives may be further added: black rice, milk, coffee, black tea, oatmeal, and egg. 一種添加維生素C鹽類之豆奶,係藉由添加一抗壞血酸鹽(ascorbate)於以至少一豆類為製造原料的一飲品內而製成,可增加小腸對鐵的吸收率,其中,該抗壞血酸鹽所貢獻之抗壞血酸離子之劑量為25~50 mg/100mL。A soy milk supplemented with vitamin C salt is prepared by adding ascorbate to a beverage made of at least one legume, which can increase the absorption rate of iron in the small intestine, wherein the ascorbate The dose of ascorbic acid ion contributed is 25-50 mg/100 mL. 如申請專利範圍第6項所述之添加維生素C鹽類之豆奶,其中,該抗壞血酸鹽係取製於天然食物。The soy milk added with vitamin C salt according to claim 6, wherein the ascorbate is taken from a natural food. 如申請專利範圍第6項所述之添加維生素C鹽類之豆奶,其中,該抗壞血酸鹽係取製於化學合成。The soy milk added with vitamin C salt according to claim 6, wherein the ascorbate is chemically synthesized. 如申請專利範圍第6項所述之添加維生素C鹽類之豆奶,其中,該抗壞血酸鹽可為下列任一種:抗壞血酸鈣(Calcium Ascorbate)、抗壞血酸鈉(Sodium Ascorbate)、抗壞血酸鋅(Zinc Ascorbate)、與抗壞血酸鉀(Potassium Ascorbate)。The soy milk added with vitamin C salt according to claim 6, wherein the ascorbate may be any of the following: Calcium Ascorbate, Sodium Ascorbate, Zinc Ascorbate, With Potassium Ascorbate. 如申請專利範圍第6項所述之添加維生素C鹽類之豆奶,其中,該豆類可為下列任一種:黃豆與黑豆。The soybean milk added with vitamin C salt according to claim 6 of the patent application, wherein the bean may be any one of the following: soybean and black bean. 如申請專利範圍第6項所述之添加維生素C鹽類之豆奶,可進一步地添加下列任一種添加物:玄米、牛奶、咖啡、紅茶、燕麥、雞蛋。As the soy milk added with vitamin C salt as described in claim 6 of the patent application, any of the following additives may be further added: black rice, milk, coffee, black tea, oatmeal, and egg. 一種添加維生素C立體異構物之豆奶,係藉由添加一抗壞血酸(ascorbate)之立體異構物(stereo isomers)於以至少一豆類為製造原料的一飲品內而製成,可增加小腸對鐵的吸收率,其中,該抗壞血酸之立體異構物所貢獻之抗壞血酸離子之劑量為25~50 mg/100mL。A soy milk supplemented with a stereoisomer of vitamin C is prepared by adding a stereoisomer of ascorbate to a beverage made of at least one legume, which can increase the small intestine to iron. The absorption rate of the ascorbic acid ion contributed by the stereoisomer of ascorbic acid is 25-50 mg/100 mL. 如申請專利範圍第12項所述之添加維生素C立體異構物之豆奶,其中,該抗壞血酸之立體異構物係取製於天然食物。The soy milk supplemented with the vitamin C stereoisomer as described in claim 12, wherein the stereoisomer of the ascorbic acid is taken from a natural food. 如申請專利範圍第12項所述之添加維生素C立體異構物之豆奶,其中,該抗壞血酸之立體異構物係取製於化學合成。The soybean milk added with the vitamin C stereoisomer as described in claim 12, wherein the stereoisomer of the ascorbic acid is taken from a chemical synthesis. 如申請專利範圍第12項所述之添加維生素C立體異構物之豆奶,其中,該抗壞血酸之立體異構物可為下列任一種:異抗壞血酸(Erythorbic Acid)、異抗壞血酸鈣(Calcium Erythorbate)、異抗壞血酸鈉(Sodium Erythorbate)、異抗壞血酸鋅(zinc Erythorbate)、與異抗壞血酸鉀(Potassium Erythorbate)。The soy milk supplemented with the vitamin C stereoisomer according to claim 12, wherein the stereoisomer of the ascorbic acid may be any one of the following: Erythorbic Acid, Calcium Erythorbate, Sodium Erythorbate, zinc Erythorbate, and Potassium Erythorbate. 如申請專利範圍第12項所述之添加維生素C立體異構物之豆奶,其中,該豆類可為下列任一種:黃豆與黑豆。The soybean milk added with the vitamin C stereoisomer as described in claim 12, wherein the bean may be any one of the following: soybean and black bean. 如申請專利範圍第12項所述之添加維生素C立體異構物之豆奶,可進一步地添加下列任一種添加物:玄米、牛奶、咖啡、紅茶、燕麥、雞蛋。As the soybean milk to which the vitamin C stereoisomer is added as described in claim 12, any of the following additives may be further added: black rice, milk, coffee, black tea, oatmeal, and egg. 一種添加維生素C之豆奶,係藉由添加一抗壞血酸(ascorbic acid)於以至少一豆類為製造原料的一飲品內而製成,可增加小腸對鐵的吸收率,其中,該抗壞血酸之添加劑量為10025~30050 mg/100mL。The soy milk added with vitamin C is prepared by adding ascorbic acid to a beverage made of at least one legume, which can increase the absorption rate of iron in the small intestine, wherein the amount of the ascorbic acid additive is 10025~30050 mg/100mL.
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