TW201235035A - Dehydration and concentration method of traditional Chinese medicine decoction - Google Patents

Dehydration and concentration method of traditional Chinese medicine decoction Download PDF

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Publication number
TW201235035A
TW201235035A TW100105090A TW100105090A TW201235035A TW 201235035 A TW201235035 A TW 201235035A TW 100105090 A TW100105090 A TW 100105090A TW 100105090 A TW100105090 A TW 100105090A TW 201235035 A TW201235035 A TW 201235035A
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Taiwan
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decoction
chinese herbal
water molecules
dehydration
environment
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TW100105090A
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Chinese (zh)
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TWI440455B (en
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jian-zhi Yu
Hui-Yi Lin
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Univ China Medical
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Abstract

A dehydration and concentration method of a traditional Chinese medicine decoction includes the following steps: (a) placing the Chinese medicine decoction in a low temperature environment sufficient to cause the water molecules condensed into ice, (b) gradually condensing the water molecules of the decoction into ice crystals so that the effective traditional Chinese medicine components of the decoction is separated from the water molecules that forms the ice crystals and (c) removing ice crystals condensed in step (b) to obtain the traditional Chinese medicine fluidextracts of low water content. The traditional Chinese medicine fluidextracts of low water content can be made rapidly by using the aforementioned method of separating Chinese medicine components and water molecules, and it does not have the thermal metamorphism effect. In addition, only simple equipments are required and the energy consumption is low.

Description

201235035 六、發明說明: 【發明所屬之技術領域】 本發明是有關於-種脫水濃縮方法 草藥湯劑脫水濃縮的方法。 種將中 【先前技術】 陸續被發現與魏,傳統巾草 ^㈣治療成效201235035 VI. DESCRIPTION OF THE INVENTION: TECHNICAL FIELD OF THE INVENTION The present invention relates to a method for dehydrating and concentrating herbal decoctions. Kind of will [previous technique] successively discovered and Wei, traditional towel grass ^ (four) treatment effectiveness

視,世界各國也料投人巾草;際藥廠的重 發出對特定疾病有獨特療效…中:的研究,以期開 製成之科學中藥的保存,避 兄义刀過多而發霉或產生變質現 將中草藥湯劑進行脫水乾燥處理,以方便後續加工 1成乾燥粉末狀或丸劑與碗劑。 目前科學中藥的脫水乾燥方式,不外乎高溫加妖乾燥, 或是真空低溫冷凍乾燥兩種& ^ 喱慝理方式,但上述兩種方式所需 之設備成本相當高’加熱乾燥方式很可能會造成中草藥中之 有效成分被破壞,致使製成之科學中藥的藥效變差,而冷康 乾無方式則通常需要抽真空,且在極低溫環境中進行(約肩 C ),所以會相當耗能,因此,對制前採用之中草藥湯劑 脫水乾燥方式確實有改良之必要。 【發明内容】 iUli ’ 之目的’即在提供一種低成本之中草藥湯 劑的脫水濃縮方法。 於疋本發明中草藥湯劑的脫水濃縮方法,包含以下步 Ka)將中草藥湯劑置於―足以致使水分子凝結成冰之低溫 201235035 環境中;(b)使中草藥湯劑中之水分子逐漸凝結成固態冰晶, 致使中草藥成分與形成冰晶之水分子分離;及(c)將步驟(b) 產生的冰晶濾、除,製成低含水量之中草藥流浸膏。 本發明之功效:透過將中草藥湯劑置於低溫環境進行結 冰,使水分子逐漸形成冰晶而與中藥成分分離的設計,可將 中草藥场劑中之大部分水分脫除,而製成含水量低之中草藥 流浸膏,其加工成本低,且不會有熱變質的情形。 【實施方式】 有關本發明之前述及其他技術内容、特點與功效,在以 下配合參考圖式之二個較佳實施例的詳細說明中,將可清楚 的呈現<» 在本發明被详細描述之前,要注意的是,在以下的說明 内容中,類似的元件是以相同的編號來表示。 如圖1〜3所示,本發明中草藥湯劑的脫水濃縮方法的第 一較佳實施例,適用於將中草藥湯劑8〇〇的大部份水分脫 除,而將中草藥湯劑800加工成低含水量之中草藥流浸膏 600,所述中草藥湯劑8〇〇是指中草藥經浸泡或其它方式製 成之水液狀湯劑,例如小柴胡湯萃取液、桂枝加芍藥湯、六 味地黃丸...等均可使用’因所述之"藥湯劑種類眾多,不 再逐一列舉。 該脫水漠縮方法包含以下步驟: 步驟(一)低溫冷凍。將欲進行脫水處理之中草藥湯劑8〇〇 置於一藥劑容H 3中,並將該藥劑容器3置放於―足以使水 分子凝結成冰之低溫環境中,使中草藥湯劑8〇〇中的水分子 201235035 開始結冰。在本實施例中,該藥劑容器3為玻璃瓶,所述低 溫環境是指〇〜-1(rc環境,本實施例是採用,但實施時, 不以此無限。 步驟(二)攪拌產生冰晶80卜在中草藥湯劑8〇〇出現結冰 見象後以攪拌器4逐漸撲動結冰中之中草藥湯劑, 促使中草藥湯齊1 800中的水分子逐漸凝結成冰晶8(H,由於 水刀子結冰形成冰晶8〇丨時,會將中草藥湯劑8〇〇中之中草 藥成分排除在冰晶801外,所以可藉此使中草藥湯劑8〇〇中 之水分子在結成冰晶801過程中,逐漸與中草藥成分分離, 並透過持續攪拌方式,避免冰晶801進一步結合成大冰塊, 降低被包覆在冰晶801中的中草藥成分量,直至原本之中草 藥湯劑800變成由冰晶8〇1與膏狀濃稠物構成之冰沙狀混合 物其中’冰晶801粒控範圍介於3〜l〇mm,至於整個冷;東 攪拌的時間,可依中草藥湯劑800體積與脫水濃縮比率決定。 步驟(三)濾除冰晶801〇將上述冰沙狀混合物置於一過濾 容器5中,並配合2〇〜5〇 mesh之篩網51進行過濾,該篩網 51之孔隙遠小於冰晶8〇1粒徑,但足以使所述膏狀濃稠物通 過。 在本實施例中,進行冰晶801之過濾時,是將該冰沙狀 混合物置於篩網51上,接著,對該過濾容器5内部進行真 空抽氣,致使該過濾容器5位於該篩網51下方的内部空間 50產生一負壓吸力,藉此負壓吸力將篩網51頂側之冰沙狀 混合物中的膏狀濃稠物往下吸引通過該篩網5丨,進而將膏狀 濃稠物與冰晶801分離,而獲得脫水後之中草藥流浸膏600, 201235035 便完成中草藥湯劑800之第一次脫水濃縮處理。此時,可依 據所得之中草藥流浸膏600之含水量狀況,考慮是否再重複 進行一次上述步驟(一)〜(三),藉以脫除更多水分。 由於過濾冰晶801的方式為習知技術,且方式眾多,不 再詳述,且實施時,濾除冰晶8〇1的方式也不以此為限。 如圖4所示,在前述步驟(二)過程中,本實施例針對四 種中草藥湯劑800分別進行實驗,該等中草藥湯劑8〇〇分別 為小柴胡湯、桂枝加苟藥湯、六味地黃丸與麥門冬湯該等 中草藥濟劑800冷凍攪拌產生之冰沙狀混合物中的中草藥成 分濃縮比例約60〜80%,會隨著冷凍攪拌產生冰晶8〇1的時 間長短而變化,當冷;束㈣時間越長,冰晶謝形成量越多, ,相對使得冰沙狀混合物中的中草藥成分漠縮比例相對提 南〇 此外,如圖5所示,步驟(二)授拌產生之冰晶謝的粒 :圣大小,也會影像響後續過渡後之中草藥流浸膏_的中草 藥成分比例’當冰晶801越大時’會有較多之令草藥成分被 冰晶801封住而無法釋出,會诰 霄成過,慮所得之中草藥流浸膏 600之中草藥成分過低。經實驗發現,當冰晶謝粒徑大於 10 mm以上,就會有將近7〇0 迎0 /〇以上的中卓藥成分伴隨冰晶 8〇1 -起被濾除’當圖5中之濾除率達1〇〇%時,表示所有_ :樂成:皆:皮冰封在冰晶801中而無法釋出,所以全部被遽 除。而¥冰晶801粒控介协q in . ΛΛ “於3〜10mm時’遽除後所得中草藥 含之中草藥成分可達原中草藥湯劑8〇〇之 〜也就是說’僅約2G〜3G%的中草藥成分被封在冰晶 201235035 801中而被濾除。 如表1所示,在攪拌時間120〜180分鐘,冰晶801粒徑 "於3 10 mm時,小柴胡湯 '桂枝加芍藥湯、六味地黃丸與 麥門冬湯分別製成之中草藥流浸膏議的中草藥成分回收比 例都可達約70%以上。 __ _ 中草藥成分 回收比例(%) 6 9〜74 % __ t 上述方法所製成之中草藥流浸膏6〇〇的含水量會相當 低,大約可低至25〜30。/。的含水率,因此,當要進一步將該 _草藥流浸膏6GG完全乾燥處理成乾粉狀時,可直接將該令 草藥流浸膏6GG攤置於室溫環境中,制自然:風乾的方式進 行乾燥,若要採用加熱乾燥時,因含水量已很低,所以僅需 採用較低溫(約45〜6Gt)之加熱溫度,^可大幅縮短加熱乾 燥時間,進而大幅降低中草藥成分產生熱變質的機率。 若是要進-步將製成之中草藥流浸膏_製成丸劑或錠 劑寺纟於3水量低’所以在加人賦形劑混合攪拌時,中草 樂流浸膏_中的水分子也會進_步揮發而再次脫水而達 到接近乾粉狀之型態,相當方便。 透過上述在中草藥湯劑8〇〇結冰過程中持續授掉的方 式,可逐漸使中草藥成分與結成冰晶之水分子分離,可在將 冰晶謝遽除後,製造出低含水量的中草藥流浸膏_,方 便進-步乾燥製成中草藥粉劑’或與賦形劑混合製成丸劑或 鍵劑’且所得中草藥流浸膏刚之中草藥成分回收比例可達 約70%以上。 另外,因為整個脫水濃縮過程是在低溫(〇〜_i(rc)環境中 201235035 广所以可確保"藥成分不會發生 :式也可採用常溫自然風乾或低溫加熱乾燥,因脫水濃缩 ^使用之設備相當簡單,且僅提供代〜_阶左右之低 :料’㈣此脫水濃縮方法的縣與能耗,都會明顯低於 傳統加熱乾燥方法與真空低溫冷凌乾燥方法。 广圖6、7、8所示,本發明中草藥湯劑的脫水方法的第 二較佳實施例與第-實施例之差異在於:本實施例未在結冰 過程進行攪拌。 在本實施例中,該脫水濃縮方法包含以下步驟: 步驟㈠隔熱處理。將容裳有中草藥湯劑8〇〇之藥劑容 器3設置於-由熱絕緣材料製成之熱絕緣環境9qi中僅使 部分藥劑容器3外露於該熱絕緣環境外。 在本實施例中,該熱絕緣環境9〇1是由一隔熱容器9〇2 所構成’且β亥隔熱谷态9〇2具有—側向開口,該藥劑容器3 是容裝在該隔熱容器9G2中,使其頂側、底側與大部分外周 側都被該隔熱容器902所包覆遮蔽,僅使藥劑容器3部份外 周側外露於該隔熱容器902開口處,也就是,將該藥劑容器 3之絕大部份部位都進行熱絕緣處理,僅部分外周側外露於 該熱絕緣環境901夕卜。為方便說明,是以該藥劑容器3右半 側局部部位外露為例進行說明。 步驟(二)局部低溫冷;東。接著,對該藥劑容器3外露 於熱絕緣環境901外之右侧部位提供一低溫環境9〇〇,本實 施例是對該㈣容器3右側部位提供—低溫氣流9Q3,此低 溫氣流903溫度為0°C,由於該藥劑容器3其它部份都已進 201235035 行熱絕緣處理,無法與外界環境進行熱交換,所以中草藥湯 劑800僅會自其鄰近該藥劑容器3之低溫狀右側部位開始降 溫’而逐漸凝結成冰’且形成之冰塊8〇2會逐漸往左擴大。 基於水分子結冰時會將雜物排除在冰晶8〇 1外的特性,水分 子會逐漸在該藥劑容器3右半側集中凝結成冰塊802,而使 絕大部份之中草藥成分集中在冰塊8〇2左側之藥劑容器3 内’而形成低含水量之中草藥流浸膏6〇〇。 低溫冷凍所需時間,可依據中草藥湯劑800體積、藥劑 容1§ 3外露之外周面面積,以及施加之低溫氣流溫度調整。 步驟(三)遽除冰塊802與冰晶801。當藥劑容器3中之冰 塊802累積到一預定量後’將該藥劑容器3取出該隔熱容器 902外,並將該藥劑容器3中之冰塊8〇2、冰晶8〇1與中草 藥流次膏狀600構成之混合物7〇〇倒入一過濾容器(圖未示) 中’依據上述第—實施例之過濾步驟,將冰塊802與冰晶801 慮除後’便可收集得到低含水量之中草藥流浸膏6〇〇。 表所示’小柴胡湯、桂枝加芍藥湯、六味地黃丸與 麥門冬场等中草藥湯劑800經過冷凍脫水後,所製成之中草 藥*又膏600的中草藥成分回收比例皆可達7〇%以上,脫水 率可達75%以上’所以中草藥流浸膏6〇〇的含水量相當低。 且只驗免現’冷凌達—預定時間以後,就不會再繼續結冰, 而會於該藥劑容器3中得到冰塊8()2、冰晶8〇1與膏狀的濃 稍膏體’此漢稠膏體京尤是濾'除冰& 802肖冰晶801後所製成 之中草藥流浸膏6〇〇。 201235035 表2 tb H Λ: X —^ .. 小柴胡湯 桂枝加爷鏟瀑 六味地黃丸 麥門冬湯 T早锻风分回收 比例(%) 83-86% 73 〜78% 75-80% 73-78% 結冰脫水率 75-85% 75 〜85% 75-85% 75-8 5% 整個中草藥流浸膏600製作過程中,只有相當少量的中 草藥成分會被包覆在該冰塊802中,且製造設備與方法都相 §簡單,同樣無尚溫熱變質的疑慮,有助於中草藥湯劑 的脫水加工處理。 表T、上所述,利用中草藥湯劑8〇〇在〇〜_1〇<>c的低溫環境 中結冰過程,進行攪拌以防止冰晶801形成大冰塊的方式, 或者疋僅對藥劑谷器3之局部外露於熱絕緣環境9〇 1外之區 域提供低溫環境900,而使藥劑容器3内之中草藥湯劑8〇〇 内的水分子自鄰近該藥劑容器3低溫側面開始結冰的設計, 可使中草藥湯劑800内的水分凝結成冰晶8〇1與冰塊, 而達到脫水現象,且經本發明脫水方法處理後所製成之中草 藥流浸膏600的中藥成分回收比例可達約7〇%以上而含水 率可低至15〜30%,可方便後續之乾燥與加工處理,整個脫 水步驟與所需設備都相當簡單,所需低溫冷凍溫度可由—般 冰箱或冰櫃提供,不需使用到傳統_4〇t冷凍乾燥設備,所以 可有效降低中草藥湯劑800的脫水乾燥的加工成本,且不會 有熱變質的情形,有助於科學中藥之發展,因此確實可達^ 本發明之目的。 惟以上所述者,僅為本發明之較佳實施例而已,當不能 以此限定本發明實施之範圍,即大凡依本發明申請專利範圍 10 201235035 内容所作之簡單的等效變化與修飾,皆仍屬本發 月專利涵盍之範圍内。 【圖式簡單說明】 圖1是本發明中草藥湯劑的脫水濃縮方法 施例的步驟流程圖; 帛. 又佳貫 圖2是該第一較佳實施例攪拌產生冰晶的示意圖; 圖3是該第—較佳實施例濾除冰晶時的示意圖; 圖4是該第—較佳實施例進行冷;東攪拌時之攪拌時間與 某湯劑之中草藥成分濃縮比例的曲線圖; 圖圖5該第一較佳實施例之冰晶粒徑與冰濾除率之曲線 圖6是本發明中草藥湯劑的脫水濃縮方法之第二較 施例的步驟流程圖; 貫 及 圖7是該第二較佳實施例進行局部低溫冷凍的 示意圖; 、、旦 圖8疋類似圖7之視圖,說明一藥劑容器内之中草藥 劑的水分子結冰後的情況圖。 11 201235035As a matter of course, countries all over the world are also expected to invest in people's grass; the re-issue of the drug factory has a unique effect on specific diseases... In the study of the scientific Chinese medicine, it is expected to open the scientific Chinese medicine, avoiding too much mold and causing deterioration. The Chinese herbal decoction is dehydrated and dried to facilitate subsequent processing of 1% dry powder or pellets and bowls. At present, the dehydration and drying method of scientific Chinese medicine is nothing more than high temperature plus demon drying, or vacuum low temperature freeze drying two kinds of & ^ gel processing methods, but the equipment cost required for the above two methods is quite high 'heating drying method is likely It will cause the active ingredients in Chinese herbal medicine to be destroyed, resulting in the deterioration of the efficacy of the scientific Chinese medicines produced. However, the cold-drying method usually requires vacuuming and is carried out in a very low temperature environment (about shoulder C), so it will be quite Energy consumption, therefore, the use of herbal decoction dehydration and drying methods before the system is indeed necessary to improve. SUMMARY OF THE INVENTION The purpose of iUli' is to provide a dehydration and concentration method for a low-cost herbal broth. The method for dehydrating and concentrating the Chinese herbal medicine decoction of the present invention comprises the following steps: Ka) placing the Chinese herbal decoction in a low temperature 201235035 environment sufficient to cause water molecules to condense into ice; (b) gradually condensing water molecules in the Chinese herbal medicine decoction Forming solid ice crystals, causing the Chinese herbal medicine component to be separated from the water molecules forming the ice crystal; and (c) filtering and removing the ice crystals produced in the step (b) to prepare a low-moisture herbal extract. The effect of the invention: by setting the Chinese herbal medicine decoction in a low temperature environment for icing, so that the water molecules gradually form ice crystals and separating from the traditional Chinese medicine components, the majority of the water in the Chinese herbal medicine field agent can be removed to prepare the water content. Low-medium herbal extracts have low processing costs and no thermal deterioration. [Embodiment] The foregoing and other technical contents, features, and advantages of the present invention will be apparent from the following detailed description of the preferred embodiments of the accompanying drawings. Before the description, it is to be noted that in the following description, similar elements are denoted by the same reference numerals. As shown in FIG. 1 to 3, the first preferred embodiment of the method for dehydrating and concentrating the Chinese herbal medicine decoction of the present invention is suitable for removing most of the water of the Chinese herbal medicine decoction 8 ,, and processing the Chinese herbal remedy 800 into Low-moisture herbal herbal extract 600, the Chinese herbal decoction 8〇〇 refers to a water-liquid decoction prepared by soaking or other methods of Chinese herbal medicine, such as Xiaochaihu decoction, Guizhi plus peony soup, Liuweidi Huang Wan...etc. can use the 'supplied" medicinal decoctions, which are not listed one by one. The dehydration method comprises the following steps: Step (1) cryogenic freezing. The herbal decoction 8 欲 which is to be dehydrated is placed in a pharmaceutical container H 3 , and the drug container 3 is placed in a low temperature environment sufficient for the water molecules to condense into ice, so that the Chinese herbal medicine decoction 8 〇〇 The water molecule 201235035 began to freeze. In the present embodiment, the drug container 3 is a glass bottle, and the low temperature environment refers to 〇~-1 (rc environment, which is used in this embodiment, but is not limited in this implementation. Step (2) stirring to produce ice crystals 80 Bu in the Chinese herbal medicine decoction 8 〇〇 appeared icy after seeing with a blender 4 gradually fluttering icing in the Chinese herbal decoction, prompting the Chinese herbal medicine Tang Qi 1 800 water molecules gradually condensed into ice crystals 8 (H, due to water When the knife is frozen and forms ice crystals, it will exclude the Chinese herbal ingredients of the Chinese herbal medicine decoction 8 〇〇 outside the ice crystal 801, so that the water molecules in the 8 中 Chinese herbal medicine decoction can be formed into ice crystal 801. Gradually separate from the Chinese herbal medicine ingredients, and through continuous stirring, avoid the ice crystal 801 further combined into large ice cubes, reduce the amount of Chinese herbal medicine ingredients coated in the ice crystal 801, until the original Chinese herbal medicine soup 800 becomes the ice crystal 8〇1 and the paste A smooth-shaped mixture composed of thick materials, wherein the 'ice crystal 801 particle control range is between 3 and l〇mm, as for the whole cold; the east stirring time can be determined according to the 800 volume of the Chinese herbal medicine decoction and the dehydration concentration ratio. ) In addition to the ice crystal 801, the above-mentioned smooth-sand mixture is placed in a filter container 5, and filtered with a mesh of 51 〇 5 〇 mesh, the pores of the sieve 51 are much smaller than the ice crystal size of 〇1, but sufficient The paste-like thick material is passed through. In the present embodiment, when the ice crystal 801 is filtered, the ice-sand mixture is placed on the screen 51, and then the inside of the filter container 5 is evacuated. The inner space 50 of the filter container 5 located below the screen 51 generates a vacuum suction force, whereby the vacuum-like suction attracts the paste-like thick substance in the smooth-sand mixture on the top side of the screen 51 downward through the sieve The net is 5丨, and then the paste-like thick substance is separated from the ice crystal 801, and the dehydrated herbal extract is obtained 600, 201235035, and the first dehydration and concentration treatment of the Chinese herbal decoction 800 is completed. For the water content of the extract 350, consider whether to repeat the above steps (1) to (3), so as to remove more water. Since the way of filtering the ice crystal 801 is a conventional technique, and the manner is numerous, the details are not detailed. Said, and when implemented, filter The method of removing the ice crystals 8〇1 is not limited thereto. As shown in Fig. 4, in the foregoing step (2), the present embodiment tests the four kinds of Chinese herbal medicine decoctions 800 respectively, and the Chinese herbal medicine decoctions 8〇 The concentration ratio of Chinese herbal medicines in the smooth-sand mixture produced by the Chinese herbal medicines 800, such as Xiaochaihutang, Guizhijiaoyutang, Liuweidihuangwan and Maimendongtang, is about 60~80%. As the temperature of the ice crystals is increased by the freezing and stirring, when the temperature is cold, the longer the beam (four) is, the more the amount of ice crystals is formed, and the relative proportion of the herbal ingredients in the smooth-sand mixture is relatively different. As shown in Fig. 5, the step (2) gives the ice crystals that are produced by the mixing: the size of the saint, and the image of the Chinese herbal medicine in the subsequent transition after the transition of the herbal medicine extract _ the larger the ice crystal 801 A lot of herbal ingredients are blocked by ice crystal 801 and cannot be released, and they will be formed. The herbal ingredients of the herbal extract 600 are too low. It has been found through experiments that when the ice crystal size is more than 10 mm, there will be nearly 7〇0 00 /〇 above the Zhongzhuo drug component with the ice crystal 8〇1 - from being filtered out'. The filtering rate in Figure 5 When it reaches 1%, it means all _: Lecheng: All: The skin ice is sealed in the ice crystal 801 and cannot be released, so it is all removed. And ¥ ice crystal 801 capsule control association q in. ΛΛ "at 3 ~ 10mm" after the removal of Chinese herbal medicine containing Chinese herbal ingredients up to the original Chinese herbal decoction 8 〜 ~ that is, only about 2G ~ 3G% The Chinese herbal medicine ingredients were sealed in ice crystal 201235035 801 and filtered out. As shown in Table 1, during the stirring time of 120~180 minutes, the ice crystal 801 particle size " at 3 10 mm, Xiaochaihu Tang 'Guizhi plus peony soup, The recovery ratio of Chinese herbal medicine ingredients of Liuwei Dihuang Pills and Maimendong Decoction, which are made into Chinese herbal extracts, can reach more than 70%. __ _ Chinese herbal medicines recovery ratio (%) 6 9~74 % __ t The water content of the 6-in-one herbal extract can be quite low, which can be as low as 25~30%. Therefore, when the _ Herbal Extract 6GG is completely dried, it is dried into a dry powder. In the case of the form, the herbal extract can be directly placed in a room temperature environment, and the natural: air drying method is used for drying. If the heat is dried, the water content is already low, so only a lower temperature is required. (about 45~6Gt) heating temperature, ^ can greatly shorten heating and drying , in turn, greatly reduce the chance of heat metamorphism of Chinese herbal ingredients. If it is to be further processed into a herbal extract, make a pill or a lozenge in a low water content of 3, so when mixing with excipients, The water molecules in Zhongcao Le Stream Extract _ will also be dehydrated and dehydrated again to reach a dry powder form, which is quite convenient. Through the above, the Chinese herbal medicine decoction is continuously granted during the icing process. In a way, the Chinese herbal medicine component can be gradually separated from the water molecules formed into ice crystals, and the Chinese herbal medicine extract having a low water content can be produced after the ice crystals are removed, so that the Chinese herbal medicine powder can be continuously dried to form a Chinese herbal medicine powder or shaped. The mixture of the ingredients is made into a pill or a key agent, and the recovered amount of the herbal extract of the Chinese herbal medicine is up to about 70%. In addition, because the whole dehydration and concentration process is in the low temperature (〇~_i(rc) environment 201235035 wide It can ensure that the ingredients of the medicine will not occur: the formula can also be dried at normal temperature or dried at low temperature. The equipment used for dehydration and concentration is quite simple, and only provides the low level of ~~ order: material '(4) The county and energy consumption of the concentration method are significantly lower than the conventional heating drying method and the vacuum low temperature cold drying method. As shown in the general drawings 6, 7, and 8, the second preferred embodiment of the dehydrating method of the Chinese herbal medicine decoction of the present invention The difference in the first embodiment is that the present embodiment does not perform the stirring process in the icing process. In the present embodiment, the dehydration concentration method comprises the following steps: Step (1) Insulation treatment. The Rongshang has a Chinese herbal decoction 8 〇〇 The medicament container 3 is disposed in a heat insulating environment 9qi made of a heat insulating material, and only a part of the drug container 3 is exposed outside the heat insulating environment. In the embodiment, the heat insulating environment 9〇1 is insulated by a heat insulating environment. The container 9〇2 is configured to have a lateral opening, and the drug container 3 is housed in the heat insulating container 9G2 such that the top side, the bottom side and most of the outer circumference side Both of them are covered by the heat-insulating container 902, and only the outer peripheral side of the drug container 3 is exposed to the opening of the heat-insulating container 902, that is, most of the portion of the drug container 3 is thermally insulated. Only part of the outer peripheral side is exposed to the heat 901 Xi Bu environment. For convenience of explanation, the local portion of the right half of the drug container 3 is exposed as an example for description. Step (2) Local low temperature cold; East. Next, the low temperature environment 9 is provided on the right side of the container 3 exposed outside the thermal insulation environment 901. In this embodiment, the low temperature airflow 9Q3 is provided to the right side of the (4) container 3, and the temperature of the low temperature airflow 903 is 0. °C, since the other parts of the drug container 3 have been thermally insulated in 201235035 and cannot exchange heat with the external environment, the Chinese herbal decoction 800 will only start to cool down from the low temperature side of the vicinity of the drug container 3. And gradually condensed into ice' and the formed ice block 8〇2 will gradually expand to the left. Based on the characteristics that the water molecules will be excluded from the ice crystals when they freeze, the water molecules will gradually condense into ice cubes 802 on the right half of the drug container 3, so that most of the herbal ingredients are concentrated in The ice cube 8 〇 2 on the left side of the drug container 3 'to form a low water content herbal extract 3.5 〇〇. The time required for cryopreservation can be adjusted according to 800 volumes of Chinese herbal decoction, the outer surface area of the medicament 1 § 3 exposed, and the temperature of the applied low temperature air stream. Step (3) removes ice 802 and ice crystal 801. When the ice cube 802 in the medicament container 3 is accumulated to a predetermined amount, the medicament container 3 is taken out of the insulated container 902, and the ice cube 8〇2, the ice crystal 8〇1 and the Chinese herbal medicine flow in the medicament container 3 are The mixture of the second paste 600 is poured into a filter container (not shown). In the filtration step according to the above-mentioned first embodiment, after the ice cube 802 and the ice crystal 801 are removed, the low water content can be collected. Herbal extract is 6 流. The table shows that the Chinese herbal medicines such as Xiaochaihutang, Guizhijiaoyutang, Liuwei Dihuangwan and Maimen Winter Farm are lyophilized and dehydrated. More than 7〇%, the dehydration rate can reach more than 75%', so the water content of Chinese herbal extracts 6〇〇 is quite low. And only the inspection of the cold lingda - after the scheduled time, will not continue to freeze, but in the drug container 3 will get ice 8 () 2, ice crystal 8 〇 1 and paste-like concentrated paste 'This Han thick paste body is especially filtered 'de-ice & 802 Xiao Bingjing 801 made of herbal extracts 6 〇〇. 201235035 Table 2 tb H Λ: X —^ .. Xiaochaihu Tang Guizhi Jiaye Shovel Waterfall Liuwei Dihuang Wan Maimendongtang T Early Forging Wind Recovery Ratio (%) 83-86% 73 ~78% 75-80% 73 -78% icing dehydration rate 75-85% 75 〜85% 75-85% 75-8 5% During the preparation of the whole Chinese herbal extract 600, only a relatively small amount of Chinese herbal ingredients will be coated in the ice 802 And the manufacturing equipment and methods are relatively simple, and there is no doubt about the warming and deterioration of the Chinese herbal medicine decoction. Table T, above, using the Chinese herbal medicine decoction 8 〇〇 in the low temperature environment of 〇~_1〇<>c, stirring, to prevent the ice crystal 801 from forming large ice, or 疋 only for the pharmacy The portion of the barn 3 is exposed to a region outside the thermal insulation environment 9 〇 1 to provide a low temperature environment 900, and the water molecules in the herbal remedy 8 药剂 in the drug container 3 are frozen from the low temperature side of the drug container 3 The design can make the moisture in the Chinese herbal decoction 800 condense into ice crystals 8〇1 and ice cubes, and achieve the dehydration phenomenon, and the recovery ratio of the traditional Chinese medicine component prepared by the dehydration method of the invention can reach about More than 7〇% and the water content can be as low as 15~30%, which can facilitate the subsequent drying and processing. The whole dewatering step and the required equipment are quite simple. The required low temperature freezing temperature can be provided by the general refrigerator or freezer. It can be used in the traditional _4〇t freeze-drying equipment, so it can effectively reduce the processing cost of dehydration and drying of Chinese herbal decoction 800, and there is no thermal deterioration, which is conducive to the development of scientific Chinese medicine. The purpose of the invention. The above is only the preferred embodiment of the present invention, and the scope of the present invention is not limited thereto, that is, the simple equivalent changes and modifications made by the content of the patent application 10 201235035 of the present invention are It is still within the scope of this patent. BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a flow chart showing the steps of a method for dehydrating and concentrating a Chinese herbal medicine decoction according to the present invention; FIG. 2 is a schematic view showing the stirring of the ice crystal by the first preferred embodiment; FIG. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 4 is a schematic view showing the filtration of ice crystals in the preferred embodiment; Fig. 4 is a graph showing the stirring time of the first preferred embodiment and the concentration ratio of the herbal ingredients in a certain decoction; FIG. 6 is a flow chart showing the steps of the second embodiment of the dehydration and concentration method of the Chinese herbal medicine decoction according to the preferred embodiment; FIG. 7 is the second preferred embodiment. For example, a schematic diagram of local cryo-freezing is performed; and Figure 8 is a view similar to Figure 7, illustrating a situation in which water molecules of a herbal medicine in a pharmaceutical container are frozen. 11 201235035

【主要元件符號說明】 3 ....... …藥劑容器 800… …·中草藥湯劑 4 ....... •…攪拌器 801… 冰ΒΘ 5 ....... •…過濾容器 802… •…冰塊 50…… …内部空間 900… •…低溫環境 51…… …·篩網 901… •…熱絕緣環境 600… •…中草藥流浸膏 902… •…隔熱容器 700… —混合物 903… 低 >孤氣'"IL[Explanation of main component symbols] 3 ....... ...pharmaceutical container 800... ...·Chinese herbal decoction 4 ....... •...Agitator 801... Hail 5 ....... •... Filter container 802... • Ice cube 50... Internal space 900... • Low temperature environment 51... Screen mesh 901... • Thermal insulation environment 600... •... Herbal extract 902... • Insulation container 700 ... —Mixture 903... Low > Orphaned '"IL

1212

Claims (1)

201235035 七、申請專利範圍: 1. 一種卡草藥湯劑的脫水濃縮方法,包含以下步驟: (a) 將t草藥湯劑置於一足以致使水分子凝結成冰之 低溫環境中; (b) 使中草藥湯劑中之水分子逐漸凝結成固態冰晶, 致使中草藥成分與形成冰晶之水分子分離;及 (c) 將步驟(b)產生的冰晶濾除,製成低含水量之中草 藥流浸膏。 2.依據申請專利範圍第丨項所述之中草藥湯劑的脫水濃縮 方法’其中,步驟(a)該低溫環境之溫度範圍介於〇~_1〇 〇C。 3.依據申言青專利範圍帛!或2項所述之中草藥湯劑的脫水濃 縮方法,其中,步驟(b)是逐漸攪拌結冰中的中草藥湯劑, 使水分子逐漸凝結成固態冰晶。 依據申請專利範圍第15戈2項所述之中草藥湯劑的脫水濃 縮方法,其中,步驟⑷是將中草藥湯劑容裝於一藥劑容 器内’並將該藥劑容器置放於一熱絕緣環境中僅使該藥 劑容器之局部側面外露於該熱絕緣環境外,並對該藥劑容 器外露於該熱絕緣環境外之部 位^仏该低溫%境,步驟(b) 疋使中草藥湯劑鄰近該藥劑.哭从雨 衆⑷谷裔外露於低溫環境之側面 部位處的水分子開始凝結成 ^ ^ ^ 战水晶’使中草藥湯劑中之中筚 成分逐漸與冰晶分離。 Μ甲之f樂 5.依據申請專利範圍第4項 ^ .甘士 所返之中草藥湯劑的脫水''麓输 方法’其中,步驟⑴是以 Θ脫水濃縮 熱絕緣材料製成 13 201235035 器包覆於該藥劑容器頂側、底側與大部分外周側,而構成 該熱絕緣環境,僅使該藥劑容器局部外周側外露該熱絕緣 環境外。201235035 VII. Patent application scope: 1. A method for dehydrating and concentrating card herbal decoction, comprising the following steps: (a) placing t herb decoction in a low temperature environment sufficient to cause water molecules to condense into ice; (b) The water molecules in the Chinese herbal medicine decoction gradually condense into solid ice crystals, causing the Chinese herbal medicine components to be separated from the water molecules forming the ice crystals; and (c) filtering the ice crystals produced in the step (b) to form a low-moisture herbal extract. 2. The method for dehydrating and concentrating a herbal remedy according to the scope of the patent application </RTI> wherein the temperature of the low temperature environment in the step (a) is in the range of 〇~_1〇 〇C. 3. According to Shen Yanqing's patent scope! Or the dehydration concentration method of the above-mentioned herbal herb decoction, wherein the step (b) is gradually stirring the Chinese herbal decoction in the icing to gradually condense the water molecules into solid ice crystals. According to the dehydration and concentration method of the Chinese herbal medicine decoction according to the patent application, wherein the step (4) is to dispose the Chinese herbal decoction in a drug container and place the drug container in a heat insulating environment. The partial side of the medicament container is exposed to the outside of the thermal insulation environment, and the portion of the medicament container exposed to the outside of the thermal insulation environment is exposed to the low temperature environment, and step (b) is performed to bring the Chinese herbal medicine decoction adjacent to the medicament. Crying from the rain (4) The water molecules exposed to the side of the low temperature environment began to condense into ^ ^ ^ Battle Crystal' to make the Chinese cockroach ingredients in the Chinese herbal medicine decoction gradually separated from the ice crystals. Μ甲的乐乐5. According to the scope of patent application, item 4 ^. Dehydration of 'Chinese herbal decoction' from Gansu's method of 'dehydration', wherein step (1) is made of hydrazine dehydrated concentrated thermal insulation material 13 201235035 package The heat insulating environment is formed on the top side, the bottom side, and the most outer side of the drug container, and only the outer peripheral side of the drug container is exposed to the outside of the heat insulating environment. 1414
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103191019A (en) * 2013-04-16 2013-07-10 中国科学院理化技术研究所 Method for preparing hydrophobic drug nanoparticles by ice template method

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103191019A (en) * 2013-04-16 2013-07-10 中国科学院理化技术研究所 Method for preparing hydrophobic drug nanoparticles by ice template method
CN103191019B (en) * 2013-04-16 2014-10-22 中国科学院理化技术研究所 Method for preparing hydrophobic drug nanoparticles by ice template method

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