TW201124396A - Fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine derivatives and methods of use thereof - Google Patents

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Publication number

TW201124396A

TW201124396A TW099133784A TW99133784A TW201124396A TW 201124396 A TW201124396 A TW 201124396A TW 099133784 A TW099133784 A TW 099133784A TW 99133784 A TW99133784 A TW 99133784A TW 201124396 A TW201124396 A TW 201124396A

Authority

TW

Taiwan

Prior art keywords

formula

compound

cancer

salt

methyl

Prior art date

2009-10-06

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• 238000000034 method Methods 0.000 title claims abstract description 80
• -1 Fluoro-substituted 3,5-dicyano-4-(1H-indazol-5-yl)-2,6-dimethyl-1,4-dihydropyridine Chemical class 0.000 title claims abstract description 64
• 229940085304 dihydropyridine derivative selective calcium channel blockers with mainly vascular effects Drugs 0.000 title abstract 2
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• 238000004519 manufacturing process Methods 0.000 claims abstract description 5
• 150000001875 compounds Chemical class 0.000 claims description 149
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• OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 36
• 150000003839 salts Chemical class 0.000 claims description 28
• 239000001257 hydrogen Substances 0.000 claims description 25
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• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 16
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• 239000012453 solvate Substances 0.000 claims description 12
• 239000002585 base Substances 0.000 claims description 9
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• 229910052731 fluorine Inorganic materials 0.000 claims description 7
• 239000011737 fluorine Chemical group 0.000 claims description 7
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
• UJOBWOGCFQCDNV-UHFFFAOYSA-N 9H-carbazole Chemical compound C1=CC=C2C3=CC=CC=C3NC2=C1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 claims description 6
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 6
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
• YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 claims description 5
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