TW201113045A - Vesicle composition and cosmetic comprising same - Google Patents

Abstract

Disclosed are a vesicle composition having excellent long-term stability and a cosmetic comprising the vesicle composition. Specifically disclosed are: a vesicle composition characterized by comprising the following components (A) to (C): (A) a cationic surfactant represented by a specific formula, (B) a sterol, and (C) water; and a cosmetic comprising the vesicle composition.

Description

201113045 VI. OBJECTS OF THE INVENTION: 1. Field of the Invention The present invention relates to a substrate composition and a cosmetic material added thereto, which are characterized by specific cationic surfactants, sterols and water, and which pass over time. In particular, it is excellent in stability, and is particularly suitable for a hair cosmetic composition which is added to the composition, and which is excellent in the affinity for hair, the permeability to the inside of the hair, and the hair cosmetic which is excellent in moisturizing feeling when applied to hair. . [Prior Art] In the past, it has been practiced to add a sterol such as cholesterol or plant solid alcohol as a component effective for hair to a hair cosmetic. In particular, cholesterol is present in the hair and is a component related to the moisture retention function of the hair, and its content is considered to be reduced by the boundary between the ages of 10 (see Non-Patent Document 1), and is used to keep moist. An important ingredient of beautiful hair that is not dry. However, it is known that a sterol derivative such as cholesterol is generally a poorly soluble substance which is hardly soluble in water or oil (see Patent Document 1), and in particular, it is very difficult to stably add to a lotion-based preparation using water as a solvent. . Therefore, many techniques are underway for the technique of stably adding such poorly soluble sterol derivatives to aqueous solvent cosmetics. For example, it is known to mix a 4-stage alkyl salt-type cationic surfactant, an amphiphilic substance, a sterol derivative, and water at a specific addition ratio, and a layered liquid crystal containing an aqueous phase therein. The bimolecular film small-3-201113045 cell body, that is, the substrate has been formed (refer to Patent Document 2). In addition, in other aspects, it is also known to add a cationic polymer (see Patent Document 3) or polyfluorene (see Patent Document 4) to a 4-stage courtyard salt-type cationic surfactant, sterol. Derivatives with ceramide to form a substrate. Further, in the case of the cationic surfactant different from the above Patent Documents 2 to 4, dicocoyl ethyl methacrylate, which has an ester structure in a hydrophobic group, is used, and cholesterol is added. An example of a sterol (refer to Patent Document 5). [Non-Patent Document 1] The Department of Cosmetics and Science of the People's Republic of China (vσ1·13 Νο·3 1 989, 1st, 34th, 1st, 39th) [Patent Document 1] JP-A-2006-176410 [Patent Document 2] [Patent Document 3] Japanese Laid-Open Patent Publication No. 2006-19235 (Patent Document 5) Japanese Laid-Open Patent Publication No. 2006-182743 Nakamatsu [Problems to be Solved by the Invention] However, in the techniques of Patent Documents 2 to 4, any of the four-stage ammonium salt type cationic surfactants is used, and the fourth-order alkyl ammonium salt type cationicity is used. In the case of the surfactant, there is a case where the basalization of the sterol is not sufficiently performed, or precipitation occurs over time due to collapse of the substrate, and crystallization is performed to cause insufficient stability such as precipitation. Even if such a substrate -4-201113045 is added to the hair cosmetic for hair, there is a problem that it is difficult to obtain affinity with the hair and penetrate into the inside of the hair: a problem of penetration, and it is difficult to obtain a moist feeling. Further, according to Patent Document 5, the poorly soluble component such as cholesterol may not be stably added to the substrate. Therefore, cholesterol or the like may be precipitated over time, and it is difficult to provide a useful effect for the hair. In view of the above, an object of the present invention is to provide a base composition which can stably add a sterol such as cholesterol, which is an active ingredient to hair, to an aqueous solvent, and which has excellent stability over time and a cosmetic material to be added thereto. In particular, it is a hair cosmetic which is excellent in the rapid affinity for hair, the permeability to the inside of the hair, and the effect of imparting a moist feeling to the hair when it is applied to the hair. As a subject. [Means for Solving the Problem] The inventors of the present invention have found that a cationic surfactant having a specific chemical structure can be combined with a sterol or water to obtain a problem over time. The base composition having excellent stability can be stably added to the water-based cosmetic, and it can be further found that 'the cosmetic for hair is obtained when it is added to the hair cosmetic and applied to the hair. It does not remain on the surface of the hair, and it is excellent in permeability, excellent in permeability to the inside of the hair, and a feeling that the active ingredient is gradually permeated. It is excellent in imparting a moisturizing effect, and the present invention is completed. That is, the present invention provides a substrate composition characterized by containing the following components (A) to (C) of -5 to 201113045: (A) a cationic surfactant represented by the following general formula (1). 1] ch3 r1co-o-(ch2)-n+~~(ch2^~o-cor2

X (1) (wherein Rico-, R2C Ο- identical or different, representing 8 to 22 saturated or unsaturated aliphatic fluorenyl groups, R3 represents -CH3, -CH2OH or -C2H4OH; m, η The same or different means 2 or 3; X means halogen, methyl sulfate, ethyl sulfate or methyl phosphate) (Β) sterol (C) water. Further, the present invention provides a substrate composition characterized in that the molar ratio (α)/(Β) of the component (Α) and the component (Β) is in the range of 100/1 to 1/4. In addition, the present invention There is also provided a base composition characterized in that the ingredient (Β) is cholesterol and/or phytosterol. Further, the present invention provides a cosmetic characterized by adding the base composition. A cosmetic suitable for the cosmetic of the present invention is a cosmetic for hair. Further, the present invention is characterized in that a monovalent lower alcohol is added as a component (D) to the base composition or the cosmetic. [Effect of the Invention] The base composition of the present invention is excellent in stability over time, and can be stably added to a cosmetic material at -6 to 201113045. In particular, when the hair cosmetic composition to which the composition is applied is applied to hair, it is excellent in affinity with the hair and excellent in permeability to the inside of the hair, and can actually feel a feeling of gradual penetration, and is excellent in the effect of imparting a moist feeling. [Embodiment] The present invention will be described in detail. The present invention relates to a substrate composition containing the predetermined components (A) to (C). In addition, in the present specification, "base composition" means a closed cell body which is spherical in water, and a Maltese cross-shaped image can be observed by a polarizing microscope, and in addition to other observation methods, The multilayered multilamellar substrate was observed by a transmission electron microscope. The cationic surfactant of the component (A) used in the present invention is a long-chain cationic surfactant represented by the following general formula (1), and is a bilayer film which forms a substrate in the present invention. Main component, [Chemical 2]

(wherein, RiO-, R2CO- are the same or different, and represent 8 to 22 saturated or unsaturated aliphatic fluorenyl groups; R3 represents -CH3, or -CH2OH, or -C2H4OH; m, η are the same or phase Iso, meaning 2 or 3: X represents halogen, methyl sulfate, ethyl sulfate or methyl phosphate). It has a 201113045 ester bond (also known as an esterquat) in the hydrophobic chain, and generally has an excellent hair conditioning effect compared to a long-chain alkyl type cationic surfactant of the same carbon number. Biodegradability is also excellent. In the present invention, by using the component (A), it is possible to prepare excellent stability over time and microscopic film fluidity (to evaluate the deformability of the bimolecular film in the base structure, hereinafter abbreviated as "base film" Since the deformability is also excellent in the base composition, when the component (B) is contained in the base formed of the component (A), the hair active component such as the component (B) precipitates over time. Phenomenon, etc. do not occur, and can be safely maintained until use. Thus, it is possible to efficiently infiltrate into the inside of the hair when applied to the hair, and to deliver the hair active ingredient such as the component (B) to the inside of the hair stably, and to impart an effect of moisturizing effect. Specific examples of the component (A) include dicocoyl ethyl hydroxyethyl methyl ammonium sulfate, distearyl ethyl hydroxyethyl methyl ammonium sulfate, and dipalmitol ethyl hydroxyethyl. For example, one of these may be used alone or in combination of two or more kinds, such as DEHYQUART L80, DEHYQUART F75, DEHYQUART AU56/G, and DEHYQUART C4046 (all of which are manufactured by Cognis). be usable. Among them, from the viewpoint of the stability of the obtained base composition over time, or the permeability (permeability) when the hair cosmetic composition to which the base composition is added is applied to the hair, especially the coconut oil Methyl ethyl hydroxyethyl methyl ammonium sulfate is suitable. The blending amount in the base composition of the component (A) of the present invention is not particularly limited, and is preferably 0.001 to 10% by mass (hereinafter simply referred to as "%"), and 0. 0 1 to 5% is Preferably. -8 - 201113045 只要In this range, a base composition excellent in stability over time or deformation of a base film can be obtained. Therefore, when it is added to a cosmetic, it is very high until use. For example, it is possible to obtain an article which is excellent in moisturizing feeling by efficiently infiltrating the hair-soluble component such as a component (Β) into the hair when it is applied. The addition of the sterol of the component (B) used in the present invention contributes to the formation of the substrate, and contributes to the wetting of the hair when the obtained base composition is added to the cosmetic for hair. sense. For example, a sterol is added to a base system containing a conventionally used cationic surfactant: distearyl dimethyl ammonium chloride (LION. AKZO, which is a long-chain alkyl group having no ester group). Then, the base system may be agglomerated or the like. However, when a sterol is added to a base system containing the above-described cationic surfactant represented by the above formula (1) (including a long-chain alkyl chain containing an ester group), the base system is remarkably stabilized as expected. This phenomenon was discovered by the inventors. The sterol of the component (B) may be, for example, cholesterol or phytosterol (/3-micosterol, campesterol, bean solid) as long as it is a substance having a sterol skeleton or a derivative thereof. Alcohol, rapeseed sterol, etc.), lanosterol, polyoxyethylene cholesterol ether, Australian walnut oil fatty acid cholesterol ester, Australian walnut oil fatty acid plant sterol vinegar, raspberry fatty acid cholesterol vinegar, oleic acid phytosterol ester, N - Laurel-L-glutamic acid bis(cholesteryl-behenyl.octyldodecyl), N-lauroyl-L-glutamic acid di(octyldodecyl)phytosterol. Hawthorn base), N-lauroyl-L-glutamic acid bis (phytosterol. octyldodecyl), oleic acid phytosterol, etc., which may be used in one type or -9-201113045 And wherein the sterol skeleton represented by the following general formula (2) and R are an aliphatic group (for example, a linear or branched alkyl group and a linear or branched alkenyl group) Sterols are preferred, especially cholesterol and phytosterols. [Chemical 3]

For the commercial product, Nissui Marine cholesterol (manufactured by Sakamoto Fisheries Co., Ltd.), Marine Cholesterol (manufactured by Kyowa Tecnos Co., Ltd.), phytosterol (manufactured by Eisai Food & Chemical Co., Ltd.), and Richterol (manufactured by Tsuno Rice Fine Chemicals Co., Ltd.) can be used. ), EMALEX CS-10 (manufactured by Nippon Latex Co., Ltd.), ELDEW PS-203, ELDEW PS-304, ELDEW PS-306 (above, Ajinomoto Co., Ltd.). The blending amount of the component (B) of the present invention is not particularly limited, and it is preferably 0.001 to 5% in the base composition, and preferably 0.01 to 3%. As long as it is used in this range, the base composition can be favorably formed, and the stability which is passed over time is excellent, and the component (B) is efficiently infiltrated into the inside of the hair, so that a sufficient moist feeling can be felt. Further, the addition ratio of the component (A) to the component (B) of the present invention is preferably such that the molar ratio (A)/(B) of the component (A) to the component (B) is 100/1 to 1/4. 'It is preferred in the range of 9/1 to 3/7. When the molar ratio of (A)/(B) is in the range of -10-201113045, the microscopic film fluidity (deformability of the base film) is excellent, and the base composition which is excellent in stability over time can be used. The component (B) which is effective for the hair is efficiently infiltrated into the inside of the hair, and the effect of the component (B) can be more effectively exerted. The water of the component (C) used in the present invention is used as a dispersion medium for the substrate, and is an essential component of the base composition and the solvent to which the cosmetic is added. The blending amount is appropriately determined depending on the other components, that is, the components (A), (B), or the components (A), (+B), and the components (D) described later or the components to be added arbitrarily. It is used in the range of 5 to 9 9 %, preferably 2 0 to 90 %, and more preferably 6 0 to 90%. In the base composition of the present invention, in addition to the above-mentioned components (A) to (C), it is possible to further enhance the stability over time for the crystallization of the component (B). °C is a liquid fatty acid. As long as it is a higher fatty acid having a liquidity of 2 5 t, any one of them may be used, and examples thereof include saturated branched fatty acids such as isomyristate, isopalmitic acid, and isostearic acid, or unsaturated acids such as oleic acid and linoleic acid. Fatty acids, etc. In addition, for vegetable oils containing unsaturated fatty acids, avocado oil, almond oil, refined jojoba oil, grape seed oil, sesame oil, wheat germ oil, rice bran oil, soybean oil, corn germ oil, canola can also be used. Oil, Australian walnut oil 'white mango flower oil, peanut oil, rose hip oil, etc. The content of the higher fatty acid which is liquid at 25 ° C is, for example, a mass ratio of 0.5 to 1.5 times the amount of the component (B). The method for producing the substrate composition of the present invention is not particularly limited, and for example, the components (A) and (B) heated to 100 ° C or higher may be dispersed in -11 - 201113045 to be heated to 90 ° C or higher. The ingredient (C) is then continuously stirred while slowly cooling to room temperature. Further, when the substrate is prepared, a component which can be arbitrarily added as described later can be appropriately added in accordance with the properties thereof, in order to enhance the feeling of use or to further improve the hair. The average particle diameter of the obtained base composition is greater than 100 nm to 10 μm, and it is preferable to obtain an average particle diameter of 50 to 500 nm by using a machine such as an extruder described later. The substrate does not collapse, the average particle diameter changes (increases), and the stability is excellent. The base composition of the present invention prepared by the above method or the like can be added to various cosmetic materials such as hair cosmetic materials. In particular, a cosmetic for hair to which the base composition of the present invention is added is suitable because it has excellent permeability to the inside of the hair. The present invention also relates to a cosmetic material to which the base composition of the present invention is added. In the cosmetic to which the base composition of the present invention is added, a lower monovalent alcohol may be added as the component (D). The lower monovalent alcohol of the component (D) is generally used as an important component in the hair cosmetic preparation for drying speed or cooling feeling during application, and contributes to an improvement in affinity to hair. It is known that in a system in which a base composition is added, it is difficult to ensure stability over time by adding a lower monovalent alcohol. However, in the present invention, by modulating the base composition using the above component (A), even if the lower monovalent alcohol of the component (D) is added, an article having good stability over time can be obtained, and the base composition is added. When the hair cosmetic is applied to the hair, it can be quickly affinityd, has excellent permeability to the hair inside -12-201113045, and actually feels the penetration of the active ingredient, and gives a good article with high moisturizing effect. The lower monovalent alcohol of the component (D) can be used without particular limitation as long as it is generally used as a cosmetic, and examples thereof include ethanol, propanol, isopropanol, etc., and in the present invention, ethanol is preferred. . The blending amount of the component (D) of the present invention is not particularly limited, and is appropriately determined depending on desired characteristics (target quality of the prepared cosmetic), such as affinity, permeability to the inside of the hair, and the like. And the total amount of the cosmetic material accounts for a large amount. 1 to 3 0% is preferred, 1 to 3 0% is preferred, 1 to 25% is better, and even 5 to 20% is better. The method for producing the cosmetic of the present invention is not particularly limited. For example, the component (A) and (B) may be dispersed in the component (C) and then cooled to room temperature to prepare a substrate. The composition is produced by adding a component (D) or an optional component described later to the base composition. Any component added is added for the purpose of expecting an improvement in the feeling of use or a further effect on the hair. By adding the base composition of the present invention to a hair cosmetic, it is possible to obtain a hair cosmetic having an active ingredient such as the component (B) without forming a base, and it is more excellent in stability over time and is used. In the case of the inside of the hair, the actual feeling of the permeability and the feeling of penetration is more excellent, and the effect of imparting a moist feeling is higher. In particular, among the cosmetic materials to which the component (D) is added, although the component (D) is originally a component having a tendency to ensure stability over time, it can be produced by adding the base composition of the present invention. For example, in the form of a cosmetic for hair, it is excellent in permeability and sensation of penetration into the inside of the hair, and is excellent in the effect of imparting sensation. In the cosmetic of the present invention, the amount of the base composition to be blended is not particularly limited, and is preferably 5% or more of the total amount of the cosmetic material, and more preferably 1% by weight or more. Alternatively, the base composition of the present invention may be used as it is directly used at 100%. Further, the dosage form of the cosmetic of the present invention is not particularly limited. From the viewpoint of maintaining the substrate in a stable manner, it is preferred to prepare a cosmetic material in which the external phase is a water type. The external phase may contain, in addition to water, various agents which are soluble and/or dispersible in water (e.g., ethanol, polyvalent alcohols, salts, delimiters, etc.). In addition to the upper parts (A) to (C) and the component (D), the base composition of the present invention and the cosmetic material to be added thereto may be added with an oil agent or an interface other than the effects of the present invention. Active agent, alcohol, metal soap gelling agent, powder, water-soluble polymer, film forming agent, resin, agent, antibacterial agent, perfume, deodorant, salt, pH adjuster, clear, ultraviolet absorber, A cosmetic ingredient for hair protection such as plant extracts, amino acids, sugars, and vitamins. In the case of an oil agent, a liquid, a paste and a solid hydrocarbon, an ester, a fatty acid (the above-mentioned high-grade fatty acid which is liquid at 25 ° C or a non-liquid higher fatty acid at 25 ° C) may be used. Oily properties such as oils and fats can be used. Specifically, for example, hydrocarbons, oils and fats, waxes, oils, ester oils, fatty acids, polyoxygenated oils, fluorine-based oils, wool, moisturizing, and the like can be used, and the agent is dissolved. The surface is described as a circle, and the condensed moisturizing agent is a hardened hair fat-14-201113045 derivative, etc., more specifically, 'for example, natural ozokerite, pure earthworm ( Ceresin), paraffin, paraffin wax, paraffin wax, waxes such as cetyl myristate, cetyl palmitate, petrolatum, mobile paraffin, isodecane, poly Hydrocarbons such as isobutylene, squalane, squalene, mobile sarcophagus, beeswax, palm wax, canary wax, cetyl wax, cetyl alcohol, stearyl alcohol, whale stearyl alcohol, behenyl alcohol Solid oil such as shea oil, butter, beef foot oil, beef bone oil, hardened butter, hardened oil, sea turtle oil, lard, horse oil, oyster sauce, liver oil, egg butter and other animal oil, coconut oil, olive oil Oil, rice germ oil, rice bran oil, castor oil, Australian walnut oil, olive oil, almonds Vegetable oil such as oil, avocado oil, camellia oil, rosehip oil, safflower oil, sunflower oil, liquid wax such as jojoba oil, isopropyl myristate, butyl myristate, isopropyl palmitate, Ethyl oleate, cetyl citrate, hexyl laurate, decyl oleate, oleic acid ester, isostearyl laurate, isostearyl myristate, isocetyl myristate , octyl dodecyl myristate, 2-ethylhexyl palmitate, heterochloromethane palmitate, isocetyl palmitate, 2-ethylhexyl stearate, stearic acid Vinegar 'isodecyl oleate, octyldodecyl oleate, cetyl 2-ethylhexanoate, cetearyl 2-ethylhexanoate, hexyl isostearate, octyl pivalate Eleventh ester, octanoic acid isostearyl vinegar, isophthalic acid 2-ethylhexyl ester, hexyl decyl dimethyl octanoate, octyl dodecyl monomethyl octanoate, 2-ethylhexyl isocyanate, Isocetyl isostearate, isostearyl isostearate, isodecyl isonenoate, ethylene glycol half-acid, propylene glycol dicaprate, dioctanoic acid neopentyl glycol vinegar, triterpenoid Acid glycerin, Ξ 2- Ethylhexanoic acid glycerol triisostearic acid glyceride, =2. ethylhexanoic acid trimethyl propylene glycol vinegar, triiso-hard -15- 201113045 ester oil such as trimethylolpropane fatty acid, lauric acid , myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, oleic acid 'linoleic acid, peanut oleic acid, docosahexaenoic acid (DHA) '12-hydroxystearic acid, different Fatty acids such as stearic acid and 2-ethylhexanoic acid, polyoxyphthalic acid such as dimethyl polyoxyalkylene or methylphenyl polyoxyalkylene, fluorine oil such as perfluorodecane, and lanolin 'liquid wool Fat, reduced lanolin, lanolin alcohol, hard lanolin 'acetate lanolin, lanolin fatty acid isopropyl ester and other lanolin derivatives. The surfactant may be any of anionic, cationic, amphoteric or nonionic. The anionic surfactant may, for example, be a fatty acid soap such as sodium stearate or palmitic acid triethanolamine. Alkyl ether carboxylic acid and its salt, carboxylic acid salt such as condensation of amino acid with fatty acid, alkane sulfonic acid, olefin sulfonate, sulfonate of fatty acid ester, sulfonate of fatty acid decylamine, alkyl sulfonate a sulfonate, an alkyl sulfate salt, a secondary higher alcohol sulfate salt, an alkyl and allyl ether sulfate salt, a fatty acid ester sulfate salt, a fatty acid alkanoamine sulfate Sulfate salts such as ester salts and Taikoo oil, alkyl phosphates, ether phosphates, alkyl allyl ether phosphates, guanamine phosphates, N-decylamino acid-based active agents, and the like. The cationic surfactant may, in addition to the component (A), an amine salt such as an alkylamine salt, a polyamine or an amino alcohol fatty acid derivative, an alkyl quaternary ammonium salt or an aromatic quaternary ammonium salt. Examples of the amphoteric surfactant include a betaine, an amino acid salt, an imidazoline derivative, and the like. Examples of the nonionic surfactant include sorbitan fat-16-201113045 acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, polyethylene glycol fatty acid ester, and sucrose fat. Acid ester, polyoxyethylene alkyl ether, polyoxypropylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, Polyoxyethylene glycol fatty acid ester, polyoxyethylene propylene glycol fatty acid ester, polyoxyethylene castor oil, polyoxyethylene hardened castor oil, polyoxyethylene plant solid alkanol ether, polyoxyethylene plant sterol ether, polyoxyethylene Cholesterol ether, polyoxyethylene cholesterol ether, polyoxyalkylene denatured organopolyoxane, polyoxyalkylene. Alkyl co-denatured organopolyoxane, lauric acid diethanolamine, coconut oil fatty acid diethanol hydrazine Amine, coconut oil fatty acid monoethanol decylamine, polyoxyethylene coconut oil fatty acid monoethanol decylamine, lauric acid monoisopropanol decylamine, coconut oil fatty acid monoisopropanol decylamine, sugar ether, glycosamine and the like. As the alcohol, as long as it is a component other than the component (D), there are glycerin, diglycerin, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol ' 1,3 - dibutyl A polyvalent alcohol such as an alcohol '1,2·pentanediol' polyethylene glycol or the like. As the metal soap, '1, 2-hydroxystearic acid, zinc stearate, aluminum stearate, calcium stearate, magnesium stearate, zinc myristate, magnesium myristate, whale base Zinc phosphate, cetyl calcium phosphate, sodium cetyl zinc phosphate, zinc laurate, zinc undecylenate, and the like. Examples of the gelling agent include amino acid derivatives such as N-lauroyl-L-glutamic acid and α-di-n-butylamine, dextrin palmitate, dextrin stearate, and paste. A sucrose fatty acid ester such as dextrin fatty acid ester such as 2-ethylhexanoic acid palmitate, sucrose palmitate or sucrose stearate, or monobenzylidene sorbitol

I I201113045, benzylidene derivative of sorbitol such as dibenzylidene sorbitol, dimethylbenzyldodecyl ammonium montmorillonite clay, dimethyldi(octadecyl)ammonium montmorillonite Organic modified clay minerals such as clay. As far as the powder is concerned, as long as it is an object used for a general cosmetic material, regardless of its shape (spherical shape, needle shape, plate shape, etc.) or particle diameter (smoke, mist, fine particles, pigment level, etc.), particle structure (porous Any of them can be used, for example, in the case of inorganic powders, magnesium oxide, barium sulfate, calcium sulfate 'magnesium sulfate, calcium carbonate, magnesium carbonate, talc, synthetic mica, mica, kaolin, strontium Mica, muscovite, synthetic mica, phlogopite, red mica, biotite, lithium mica, citric acid, anhydrous citric acid, aluminum citrate, magnesium citrate, aluminum magnesium citrate, calcium citrate, strontium citrate, citric acid Bismuth, tungstate metal salt, hydroxyapatite, vermiculite, gibbsite, montmorillonite, zeolite, ceramic powder, calcium phosphate, aluminum oxide, aluminum hydroxide, boron nitride, nitrogen boron compound, etc.; For organic powders, 'polyamide powder, polyester powder, polyethylene powder, polypropylene powder, polystyrene powder, polyurethane, benzoguanamine powder, polymethylbenzamide powder, Tetrafluoroethylene powder, polymethyl methacrylate methyl vinegar powder, cellulose, silk powder, nylon powder, resistant 12, nylon 6, styrene. Acrylic copolymer, divinylbenzene. This ethylene burning copolymer, ethylene resin, urea resin, enamel resin, fluororesin, enamel resin, acrylic resin, melamine resin, epoxy resin, Polycarbonate resin, microcrystalline fiber powder, lauric acid, etc.; in the case of color pigments, 'iron oxide, iron hydroxide, titanic acid, inorganic red pigment, r-iron oxide, inorganic brown pigment, yellow Inorganic yellow pigments such as iron oxide and loess, inorganic black pigments such as black iron oxide and carbon black, inorganic purple pigments such as manganese violet and guar, chromium hydroxide, chromium oxide, cobalt oxide, cobalt titanate, etc. -18- 201113045 Inorganic Inorganic blue pigment such as green pigment, dark blue or ultramarine; a material obtained by lake-forming a coal-based pigment, a material obtained by lake-forming a natural pigment, and a composite powder obtained by combining the powder; In the case of pigments, 'titanium oxide coated mica, titanium oxide coated mica, yttrium oxychloride, titanium oxide coated yttrium oxychloride, titanium oxide coated talc, fish scale foil, titanium oxide coated pigmented mica, etc.; In terms of powder pigments, aluminum powder, copper powder, stainless steel powder, etc.; in terms of coal char pigment, red No. 3, red No. 104, red 106, red 201, red 202, red 204, red 205, Red 2 2 0, red 2 2 6 , red 2 2 7 , red 2 2 8 , red 23 0 , red 401, red 5 05 , yellow 4 , yellow 5 , yellow 202 , Yellow 203, Yellow 204, Yellow 401, Blue 1, Blue 2, Blue 201, Blue 404, Green 3, Green 201, Green 204, Green 205, Orange 201 No., orange 203, orange 204, orange 206, orange 20 7, etc.: in terms of natural pigments, it may be a powder selected from the group consisting of cochinic acid, laccase, crocin, Brazilian hematoxylin, crocin, and the like. A powder, or a powder of a surface treated with an oil agent, a polyoxygen or a fluorine compound, in the form of a gum, a gum arabic, a galactan , locust bean gum, guar gum, carrageenan, carrageenan, pectin, agar, hazelnut, alginate (algae colloi) d), plant-based polymers such as trant gum, ugly gum, polygalactomannose, xanthan gum, polydextrose, glycosides, microcystis, etc. Starch-based polymer such as starch, carboxymethyl starch, methyl hydroxypropyl starch, methyl fiber-19- 201113045, ethyl cellulose, methyl hydroxypropyl cellulose, carboxymethyl cellulose, methylol Cellulose, hydroxypropylcellulose, nitrocellulose, sodium cellulose sulfate, sodium methacrylate, crystalline cellulose, cellulose powder, and other cellulosic polymers, sodium alginate, propylene glycol alginate, etc. Vinyl polymer, polyvinyl methyl ether, carboxyvinyl polymer, alkyl modified carboxyvinyl polymer, vinyl polymer, polyoxyethylene polymer, polyoxyethylene polyoxypropylene copolymer polymer, polyacrylic acid An inorganic polymer such as an acrylic polymer such as sodium, polyethyl acrylate or polyacrylamide, a polyethyleneimine, a cationic polymer, a bentonite, a laponite (LAPONITE) or a hectorite. Further, it includes a film forming agent such as polyvinyl alcohol or polyvinylpyrrolidone. Examples of the humectant include, for example, chondroitin sulfate, hyaluronic acid, mucin, dermatan sulfate, heparin, keratan sulfate, and the like, a protein such as soybean protein 'wheat protein, or the like, collagen, and elasticity. Protein, keratin, etc. Examples of the antibacterial agent include benzoic acid, sodium benzoate, salicylic acid, phenolic acid, sorbic acid, potassium sorbate, p-hydroxybenzoic acid ester, p-chloro-m-cresol, and hexachlorophenol. , chlorodimethylammonium chloride, chlorhexidine chloride, di-n-carbon aniline, photoreceptor, bis(2-pyridylthio-1-oxidized) zinc, phenoxyethanol, iso Examples of the propylene glycol and the like are as far as the ultraviolet absorber is used. For example, the diphenyl ketone may be exemplified by 2-hydroxy-4-methoxydiphenyl ketone or 2-hydroxy-4-methoxydiphenyl ketone. 5-sulfonic acid, sodium 2-hydroxy-4-methoxydiphenyl ketone-5-sulfonate, 2,2'-dihydroxy-4,4'--20- 201113045 dimethoxydiphenyl ketone , 2,2·-dihydroxy-4,4·-dimethoxydiphenyl ketone-5-sulfonate, 2,4-dihydroxydiphenyl ketone, 2,2,,4,4,- Tetrahydroxydiphenyl ketone, etc. ' ΡΑ The lanthanide may be exemplified by amino benzoic acid, p-amino benzoic acid ethyl ester, p-amino benzoic acid glyceride, p-dimethylamino benzoic acid amyl ester, p-dimethylamino benzoic acid-2-ethyl Examples include hexyl ester, p-dihydroxypropyl benzoic acid ethyl ester, and the like, and cinnamic acid is exemplified by Ρ-methoxycinnamic acid-2-ethylhexyl ester, 4-methoxycinnamic acid-2-ethoxyethyl ester, and the like. Examples of the salicylic acid include 2-ethylhexyl salicylate, phenyl salicylate, and monomenthyl salicylate. Other examples include 2-(2-hydroxy-5-methylphenyl). Benzotriazole, 4-tert-butyl-41-methoxydibenzopyridylmethane, oxybenzone, and the like. Examples of the pH adjuster include lactic acid, citric acid, glycolic acid, succinic acid, tartaric acid, malic acid, phosphoric acid, and the like, potassium carbonate, sodium hydrogencarbonate, ammonium hydrogencarbonate, etc., in the case of a cooling agent, List L-menthol, camphor, etc. As far as the plant extract is concerned, white birch, witch hazel, sage, hop, rosemary, rose, orange, asparagus, medicine, scutellaria, honeysuckle, perilla, pepper, mountain pepper, ramie, tea , carrots, saponins, sage, grapes, seaweed, soybeans, elders and other plants or crude extracts. Examples of the amino acid include glycine, lysine, isoleucine, histidine, alanine, arginine, lysine, serine, cysteine, and ethyl sulfonate. Cystamine and the like. Examples of the sugars include glucose, fructose, galactose, mannitol, and sorbitol. In terms of vitamins, vitamin A and its derivatives, vitamins 21 - 201113045, B and its derivatives, vitamin C and its derivatives, vitamins and their derivatives, linoleic acid and its derivatives are listed. Such as vitamin F; plant phytonadione, vitamin K2 (Menaquinone), vitamin K3 (Menadione), naphthalenediol and other vitamins κ; eriocitrin (eriocitrin), citrin and other vitamins p; Others include biotin, carnitine, and ferulic acid. The cosmetic material such as a cosmetic for hair to which the base composition of the present invention is added is not particularly limited in terms of the dosage form, and can be prepared into a liquid, an emulsion state, a creamy form, a gel form, etc., and can be made into, for example, a hair lotion. Non-bath hair products such as hair cream, hair cream, hair conditioner, and split hair paint, or hair cosmetics such as hair rinse, hair care film, shampoo and other hair products for bathing. Alternatively, it can be applied in the form of spray hair spray or styling mousse in combination with a propellant. It is particularly effective in a dosage form such as a hair lotion containing a component (D) such as ethanol. In other words, in the dosage form in which the component (B) is added to the emulsified composition, if the blending amount of the component (D) is increased, it is difficult to be stably added, and in the dosage form using the base composition of the present invention, It is possible to ensure the stability over time, and at the same time, it is excellent in affinity for hair, and the cosmetic material which adds the component (D) with the advantage of setting the composition of the present application is fully utilized, for example, by The component (A) and (B) are dispersed in the component (C) in the above manner, and then cooled to room temperature to prepare a base composition, and the component (D) is added to the composition. Further, the preparation of the base composition can be similarly carried out by appropriately adding the above-mentioned optional components in accordance with the properties thereof, in order to enhance the feeling of use or to further improve the hair. -22- 201113045 [Examples] Hereinafter, the present invention will be further described in detail by way of examples. In addition, these do not impose any limitation on the invention. Example 1 (Inventive product 1 and Comparative product 1): Base composition The base composition using the component (A) of the present invention was prepared by the formulation disclosed in the following Table and the following production method (Inventive Product 1) In place of the base composition (Comparative 1) of the component (A) using a general 2-chain alkyl 4-ammonium salt type cationic surfactant, it was confirmed by the following method that the substrate was formed, and further the substrate was formed. The change (average particle size) evaluates the stability over time. Further, the fourth-order alkylammonium salt type cationic surfactant used in the comparative product 1 is distequinone dimethylammonium chloride ("Arquad 2HP-75" LION. AKZO Co., Ltd.). <Confirmation of Substrate Formation> Polarized light microscope (DP-70, manufactured by Olympus Co., Ltd.) was observed under crossed-nickel ear ' 'for the presence of a substrate (indicator of formation of a base: presence of a Maltese cross-shaped image) confirm. In addition, a penetrating electron microscope (HITACHIH-7650 pressurization voltage was used for the obtained base composition (an aqueous solution of 1% phosphotungstic acid was added in an amount equal to 10 times diluted with purified water to perform negative dyeing): 80kV) for observation. The formation of the substrate can be confirmed by using a multilayer substrate having a multilayer structure as an index. By the observation of a polarizing microscope, a majority of the -23-201113045 Maltese cross-shaped image (indicator formed by the substrate) was observed in the present invention 1, and in addition, observation by a transmission electron microscope was observed. A multilayer substrate constructed. A photograph of the present invention 1 observed by a transmission electron microscope is shown in Fig. 1, and a photograph observed by a polarizing microscope is shown in Fig. 2.

(%)

Ingredients The present invention 1 Comparative product 1 1 Dicocoyl ethyl hydroxyethyl methyl ammonium sulfate methyl ester (80%) propylene glycol solution *1 1 _ 2 chlorinated dimethythyl dimethyl ammonium 75% isopropanol solution * 2 . 1 3 Cholesterol*3 0.194 0.212 4 Residual amount of refined water residue (A)/(B) Mohr ratio*4 7/3 7/3 Evaluation of stability over time Average particle size of substrate (just modulated When finished) (after 3 days) (after 1 month) 169.3nm 184.2nm 163.3nm 397. lnm 153.0nm -*5 <Decision> ◎ X *1 : Described DEHYQUART L80 (made by Cognis, with nutmeg) Molecular weight converted from base: 683) *2: The amount of blending of Arquad 2HP-75 (manufactured by LION. AKZO, average molecular weight: 5 85.5) »3 : Nissui Marine cholesterol (average molecular weight manufactured by Nippon Fisheries Co., Ltd.: 386 *4 : The molar ratio of the comparative product 1 is a substitute component (the molar ratio of the substance added by (4) *5: the average particle diameter of the substrate "-": the state which cannot be quantified due to the collapse of the base material - 24 - 201113045 (Manufacturing method) A • Heat components 1 to 3 to 1 0 0 t: dissolve them. B: Heat component 4 to 9 〇〇c. C · Add A to B 'and The mixture was stirred and stirred by a homomixer D. The C was cooled to room temperature to obtain a substrate composition. <Evaluation of stability over time> Evaluation of stability over time was determined by the following method (observation) The change in the average particle size and state of the substrate over time is further determined using the following criteria. The results are disclosed in the above table (evaluation method). The substrate composition of the present invention 1 and the comparative product 1 The sample was heated to 6 Torr, and passed through an extruder (manufactured by Avanti Polar Lipids Co., Ltd.) equipped with a PC film (pore diameter: 200 nm WHATMAN) 10 times at 60 ° C to prepare a sample. Using the dynamic light scattering method (Beckman Coulter N5), the average particle diameter of the prepared sample was set to stand at 3 ° C for 3 days and 1 month after the preparation was completed. The degree of change (increase) of the average particle diameter of the sample after one month from the completion of the preparation or the state of the substrate is determined using the following four-stage determination criteria. -25- 201113045 < 4 stages Judgment criteria> (decision): (change in average particle diameter after completion of one month and change in state immediately after completion of modulation) ◎ (very good): no change was observed, or 2 of the average particle diameter just after completion of preparation Less than 2 times (good): more than 2 times and less than 5 times △ (slightly bad): more than 5 times and less than 20 times x (bad): more than 20 times, or a state that cannot be quantified due to base collapse The results of observation by a transmission electron microscope and a polarizing microscope (Figs. 1, 2) and the results of the above table show that the base composition of the present invention 1 using the component (A) forms a good base composition, which passes over time. Stability is also excellent. On the other hand, the base composition of the comparative product 1 of the component (A) was replaced with a 2-long-chain 4-stage alkyl ammonium salt type cationic surfactant, and although the substrate was formed, it was compared with the substrate immediately after preparation. The average particle size of the substrate after 1 month is severely increased, or the basement collapses (widening of the particle size distribution), which is a poor article from the viewpoint of stability over time. Example 2 (Inventive Products 2 to 4): Base Composition In the preparation of the above-mentioned inventive product 1, except for the dicocoyl ethyl hydroxyethyl methyl ammonium sulfate used as the component (A) ( 80%) propylene glycol solution was changed to dipalmitol ethyl hydroxyethyl methyl ammonium sulfate (90%) isopropanol-26- 201113045 Other than the solution 'The base composition was prepared in the same manner (hereinafter referred to as "this" Invention 2"). In addition, the base composition was prepared in the same manner except that the molar ratio 7/3 of (A)/(B) of the present invention 1 was changed to 1/4 (hereinafter referred to as "the present invention 3" ). Further, isostearic acid is added to the product 3 of the present invention, and a base composition (hereinafter referred to as "the present invention 4") is prepared in the same manner. As in Example 1, the state change of the substrate was evaluated. The formulations and results are disclosed in Table 2 below. [Table 2] (%) Ingredient The present invention 2 Inventive product 3 Inventive product 4 1 Dicocoyl ethyl hydroxyethyl methyl ammonium sulfate (80%) propylene glycol solution *1 - 1 1 2 Dipalmitole Ethyl hydroxyethyl methyl ammonium sulfate (90%) isopropanol solution * 2 1 - - 3 Cholesterol * 3 0.194 1.8 1.8 4 Isostearic acid 1.8 5 Refining water residual amount Residual amount (A) / ( B) Moerby*4 7/3 1/4 1/4 Evaluation of stability over time <Judgement> ◎ 〇 ◎ (Manufacturing method of the present invention 2 to 4) A : Composition 1 to 4 Heat to 1 〇〇 ° c to dissolve. B: The component 5 was heated to 90 °C. C: A was added to B ' and stirred by a homomixer. D: The C was cooled to room temperature to obtain a substrate composition. -27- 201113045 <Evaluation of permeability to hair inside (observation of hair cut surface)> Example 3 (Inventive product 5 and Comparative products 2 to 4) Next, the formulation disclosed by the following table and the next In the production method, a base composition (sample) containing a fluorescent marker: pyrene was prepared, and the permeability to the inside of the hair was evaluated by the following method. [Table 3] Ingredients The present invention 5 Comparative product 2 Comparative product 3 V/iv Comparative product 4 Figure 3-1 Figure 3-2 Figure 3-3 Figure 3-4 1 Dicocoyl ethyl hydroxyethyl methyl ammonium sulfate Methyl ester (80%) propylene glycol solution *1 0.855 0.855 - - 2 monoalkyldimethylammonium chloride 75% isopropanol solution *2 - - - 0.7825 3 Cholesterol*3 0.0965 0.0965 0.0965 4 芘0.00303 0.00303 0.00303 5 Flow Paraffin 99.99697 6 Refining water residual amount Residual amount (α) / (β 谟 ear ratio ※ 4/1 4/1 _ 4/1 ※ ※ Comparing product 4 molar ratio 'separation component (eight) added Mohr ratio of the substance (manufacturing method) A: The components 1 to 5 are heated to i 〇 (rc to dissolve. B: The component 6 is heated to 90. (: C: A is added to B, mixed with a homomixer Stirring: D: The sample was prepared by cooling C to room temperature. -28- 201113045 (Evaluation method) (1) The hair bundle (hair) was immersed in the above-mentioned table and the above-mentioned manufacturing method to prepare a crucible containing Sample such as base composition 丨 2 hours (2) The hair was taken out from (1), resin-embedded, and a section of the transverse section of the hair was made by a microtome (3). 2) Sectioning of the transverse section of the hair (observation conditions of the fluorescent microscope: excitation filter: 3 3 0 to 3 8 5 nm fluorescent filter: 420 nm exposure time: 〇.2〇S). For the obtained substrate The composition is evaluated for the permeability of the base composition (cholesterol) into the hair by observing the permeability of the fluorescent marker to the inside of the hair. Observation of the fluorescent microscope of the above (3) (photograph) It is disclosed in the photograph of Fig. 3 and Fig. 3, Fig. 3-1, Fig. 3-2, Fig. 3-3, and Fig. 3-4 are respectively immersed in the product of the present invention 5 'Comparative product 2 (fluorescent label; A cross-sectional view of the hair of the sample of the comparative product 3, the comparative product 3, and the comparative product 4. In the photograph of Fig. 3, the portion emitting blue-white light (the portion observed as white in the black-and-white pattern) indicates fluorescence. The identified 芘 exists. By the photograph of Fig. 3, almost no object was observed in Fig. 3-2 immersed in the comparative product 2 to which ruthenium was not added (the shape of the hair cut surface could not be known), and immersion was performed only by adding lanthanum to the hydrocarbon. Figure 3 - 3 of the oil comparison product 3, which looks blue but only faintly distinguishes the hair cut surface The degree of the state (white in the black and white pattern) 'Complete to the comparative product 4 of the second-chain 4-stage alkyl ammonium salt type -29- 201113045 cationic surfactant instead of the component (A) 4 Compared with the immersion in the comparative product 3, the blue-white color (white in the black and white pattern) is slightly strong to distinguish the state of the hair cut surface, but it is understood that there is no significant difference. On the other hand, in Fig. 3-1 immersed in the base composition of the present invention 5, compared with the comparative test example, the entire cut surface of the hair was clearly blue-white (white in the black and white pattern) until the hair was The center of the area is clearly bright. That is, it is understood that the base composition of the present invention 5 prepared by using the component (A) has a very high permeability to the inside of the hair. This is considered to be because the ester bond of the component (A) in the lipophilic group generates microscopic polarity, and therefore the film fluidity (deformability of the base film) of the base film becomes excellent, and it easily penetrates into the hair. Give full play to high permeability. (Experimental conditions and results relating to moisture retention ability) Further, the present invention 5 prepared by the above method was allowed to permeate into the hair to quantify the ratio of the bound water in the hair. The results are disclosed in Figure 4. This effect is related to the effect of the hair cosmetic (hair conditioner) on imparting a moist feeling to the hair. In addition, a near-infrared spectrophotometer "Spectrum 400" (manufactured by Perkin Elmer Co., Ltd.) was used, and a hair bundle (about 5 g) composed of the same human hair was used as a test sample. Specifically, it is as follows. The product 5 of the present invention was applied to a hair bundle 'to be sufficiently dried to obtain a hair sample. As a comparative control, the purified water was applied to a hair bundle (about 5 g) of the same human hair, and it was sufficiently dried to obtain a control hair sample -30-201113045. The near-infrared spectroscopy is carried out in the range of 5 3 5 〇 c η Τ 1 to 4 9 5 0 c ιτΓ1, and the following formula 1 is applied, and the ratio of the combined water in the hair is determined from the peak area of the obtained spectrum. Formula 1 Binding water ratio (%) = {peak area 1 / (peak area 1 + peak area 2)} χ 1 peak area 1 (515001^1~495 0() 11^): Strongly bound water (meaning moisture It is difficult to evaporate from the hair. Peak area 2 (5 3 5 0 (^111"~5150(^1^1): weakly bound water (meaning that water is easily evaded by hair) From the results disclosed in Figure 4, it can be seen that The ratio of the bound water in the hair of the hair sample of the present invention 5 was significantly increased as compared with the hair sample for the control of the coated purified water. This phenomenon indicates that the moisture retention ability of the hair by the coating of the present invention 5 is It is also known that this effect is a cause of imparting a moist feeling to the hair. Example 4 (Evaluation of the stability of the base composition over time) The palmitoylethylhydroxyethylammonium sulfate sulfate was separately prepared ( DEQ) 1 part by mass of base sample 1 obtained by dispersing 99 parts by mass of water (ie, DEQ/CL=10/0 (mole ratio)), DEQ and cholesterol (CL) at a molar ratio of 7/3 Premixed, and 1 part by mass of the base sample 2 obtained by dispersing 99 parts by mass of water (ie, DEQ/CL = 7/3 (Morby-31 - 201113045 rate)) a base sample 3 obtained by dispersing 1 part by mass of distearyl dimethyl ammonium chloride (DSAC) in 99 parts by mass of water (that is, DSAC/CL: 10/0 (mole ratio)) and DSAC And CL was premixed at a molar ratio of 7/3, and 1 part by mass thereof was dispersed in 99 parts by mass of water to obtain a base sample 4 (i.e., DSAC/CL = 7/3 (mole ratio)). The reagents used for the preparation of the respective samples were the same as those of the reagents used in Example 1. In terms of preparation of each sample, the components were dissolved in tetrahydrofuran (THF), and the solvent was removed by a rotary evaporator. (THF), and the mixture was heated to 8 ° C, and the purified water was injected, and ultrasonic wave irradiation was performed for 30 minutes using a probe type ultrasonic irradiation machine "VCX130PB" (manufactured by SONIC & MATERIALS Co., Ltd.). The solid content concentration was uniformly 1% by mass. The obtained base dispersion was subjected to a plurality of treatments by an extruder to make the average particle diameter uniform, and then the change in the average particle diameter with time was observed. Sample, confirming the Maltese cross image at the beginning, that is, confirming the substrate The results are respectively disclosed in Fig. 5 and Fig. 6. From the results disclosed in Fig. 5, it is known that methyl palmitate ethyl hydroxyethyl methyl ammonium sulfate (1) is contained in one of the components (A) of the present invention. In the base composition of DEq), the sample 2 to which cholesterol was added was smaller than the sample 1 to which no cholesterol was added, and the diameter of the base particle did not change, and the stability over time was excellent. On the other hand, As a result of the disclosure, it was found that in the base composition containing distearyl dimethyl ammonium chloride (DSAC) having a long-chain hospital group having no vinegar bond, the stability of the sample 4 due to the addition of cholesterol was over time. -32- 201113045 Significantly reduced. In addition, the base sample 1 (i.e., DEQ/CL: 1 〇 / 〇 (mole ratio)) prepared in the above manner and the base sample 2 (i.e., DEQ/CL = 7/3 (mole ratio)) The differential scanning calorimetry was measured, and the results were revealed in Fig. 7 » In addition, the measurement system used "DSC 7 0 2 0" (manufactured by S 11 company), the control material was alumina powder, and the temperature rising condition was set to 1 ° C / mi η The measurement was carried out in the range of 30 ° C to 110 °. From the DSC curve disclosed in Fig. 7, in the base sample 1, an endothermic peak generated by the colloid-liquid crystal transfer of DEQ observed in the vicinity of 35 ° C to 45 ° C (circular in the figure) The portion enclosed by the mark disappeared in the base sample 2, showing that the DEQ and CL are compatible at the molecular level, forming a heat-stable colloid-liquid crystal intermediate. Example 5 (Invention 6~1 〇 and Comparative Products 5 to 7): Cosmetics for hair (hair care lotion) The hair cosmetic preparation was prepared by the following formulation disclosed in the following table and the following production method. Regarding (A) stability over time, (b) affinity for hair, (c) penetration into hair, and moist feeling, the evaluation was carried out by the following method. The results will not be revealed in the table below. -33- 201113045

Ingredients Cocoon ethyl hydroxyethyl methyl ammonium sulfate methyl cool (80%) propylene glycol solution *1 The present invention t products

Dialkyldimethylammonium chloride (75%) isopropyl alcohol solution *2__ Sterols β 0.0135 0.59 5.4 0.59 0.59 0.64 3 -—-0j54 4 Stearyl alcohol 5 Ethanol 20 20 Isopropanol

* The molar ratio of the comparative products 5 to 7 is the molar ratio of propylene glycol to the components added to the components (A) and (B) (manufacturing method) A: heating the components 1 to 5 to 1 〇〇〇 c It dissolves. B: The ingredient 8 was heated to 9 〇t. C: A was added to B, and the mixture was stirred with a homomixer. D: Allow C to cool to room temperature. E: Component 6 &gt; 7 was added to hydrazine to obtain a cosmetic for hair (hair conditioner). -34- 201113045 (Evaluation method) (A) Stability determined over time (Evaluation) The stability of the passage was determined by the same method as in the above Example 1 with time. (Evaluation method) (B) Affinity to hair (C) A feeling of moisturization (D) in the hair is given, and an absolute evaluation of the moisture is given to (B), and the average is given. The participation of the participants in the special symposium and the sensation of penetration into the hair were carried out by the participants in each of the following five stages of evaluation. The judgment criteria of the four stages are judged. <5-stage evaluation criteria> (score): (evaluation) 5 points: very good / very strong feeling 4 points: good/strong feeling 3 points: normal / slightly Feel 2 points: slightly bad / not able to feel 1 point: bad / not felt -35- 201113045 &lt; 4 stage judgment criteria &gt; (judgment): (average score of score) ◎: more than 4.5 minutes: More than 3.5 points and less than 4.5 minutes △: more than 1.5 points and less than 3.5 points X: 1.5 points or less As shown by the results shown in the above table, the hair cosmetics of the present invention 6 to 10 are either Compare the hair of 5~7 Compared cosmetic material, the stability over time are more excellent, when applied to the hair, you can quickly feel the actual affinity, cosmetic permeate to the permeate inside the hair feeling, moist feeling to impart more excellent. In addition, the present invention, which has a component (D) which is difficult to secure the stability tendency over time, is also added to the hair, the affinity with hair, the feeling of penetration into the hair, the feeling of moisturization, and the like. In addition, it is excellent in the feeling of use, and it is sufficient to exhibit the stability over time, and in particular, the present invention 9 in which ethanol is added as the component (D), and when it is applied, it is excellent in affinity with hair and excellent in penetration. . On the other hand, Comparative Products 5 and 7 in which a long-chain 4-stage alkylammonium salt type cationic surfactant is generally used, and a comparative product 6 in which stearyl alcohol is added instead of the component (B) are also included. One has poor stability over time and the penetration into the hair is not good. Further, in the comparative product 4 in which the higher alcohol is used instead of the component (B), even if the component (A) is used, the stability over time and the penetration into the hair are poor, and the moist feeling is poor. -36- 201113045 Example 6: Base composition (ingredient) (%) 1. Dimethyl hydroxyethyl methyl ammonium methyl sulfate 90% isopropanol solution * 4 3 2. Plant sterol * 5 0.36 3.1 , 2-pentanediol 5 4. Purified water residue *4: DEHYQUART AU56/G (manufactured by Cognis, molecular weight: 751) *5: Phytosterol (manufactured by Eisai Co., Ltd., average molecular weight: 409.4) (Manufacturing method) A : The ingredients 1 to 3 were heated to 1 〇〇 ° c to dissolve. B: The component 4 was heated to 90 °C. C: A was added to B ' and emulsified by a homomixer. D: The C was cooled to room temperature to obtain a substrate composition. The results of the evaluation of the substrate composition of Example 6 in the same manner as in Example 1 'formed a good substrate' observed a Maltese cross-shaped image. In addition, the change in the average particle diameter with time is small, and the stability is also excellent. In addition, in the base composition of Example 6, the molar ratio (A)/(B) of the component (A) and the component (B). Is 4. Example 7: Hair cosmetic (hair care) -37- 201113045 (ingredient) (%) 1. Dicocoyl ethyl hydroxyethyl methyl ammonium sulfate 80% propylene glycol solution *1 3 2. Cholesterol* 3 0.75 3. Olive oil 0.75 4. Propylene glycol 5 5. Refined water residue (manufacturing method) Λ : Heat components 1, 2 and 3 to 1 〇〇. (: Dissolve it. B: Heat component 5 to 90. (: C: Add A to B' and mix and stir with a homomixer. D: Allow C to cool to room temperature to obtain a base composition. Component 4 was added to D, and cooled to room temperature. F. E was added to a container to obtain a hair cosmetic (hair lotion). For the hair cosmetic (hair care) of Example 7, and Example 1, As a result of the evaluation by the same method as in Example 3, a Maltese cross-shaped image was observed, and it was found that a good substrate was formed. In addition, the ampoule, the affinity with hair, the sensation of penetration, and the wetting were observed over time. In addition, in the hair cosmetic (hair care lotion) of Example 7, the molar ratio of the component (A) to the component (B), (A) / (B) is i 8 Example 8: Hair cosmetic (hair conditioner) -38 - 201113045 (ingredient) (%) 1. Dicocoyl ethyl hydroxyethyl methyl ammonium sulfate 80% propylene glycol solution 3 2. Cholesterol*3 0.36 3. Refined water 3〇4. Dimethyl polyoxyalkylene (100CS) 0.5 5. Iso-stearate.54 6. Propylene glycol 5 7. Ethanol 5 8 . Amount 9. Fragrance 〇 &gt; 1 (Manufacturing method) A: The components 1, 2 and 5 were heated to dissolve at 100 ° C. B: The component 3 was heated to 90 ° C. C : A was added to B to Mixing with a homomixer D: Cooling C to room temperature to obtain a base composition E: Adding ingredients 4 and 6 to hydrazine and uniformly mixing F: Adding ingredients 7 to 9 to e, and uniformly mixing. : F was filled in a container to obtain a hair cosmetic (hair lotion). The results of evaluation of the hair cosmetic (hair conditioner) of Example 8 were carried out in the same manner as in Example 1 and Example 3. A good Maltese cross-shaped image was observed, and it was found that a good substrate was formed. In addition, it was excellent in all aspects of stability over time, affinity with hair, penetration, and imparting moist feeling. - 201113045 Further, in the hair cosmetic of Example 8, the molar ratio (A)/(B) of the component (A) to the component (B) was 3.8. Example 9: Cosmetics for hair (protection) Hair essence) (ingredient) (%) 1. Base composition 90 of the present invention 1. 2. Refined water 4.6 3. Glycerol 5 4. Sorbitol 0.1 5. Glycine 0 .1 6. Seaweed Essence 0.1 7. Perfume 0.1 (Manufacturing Method) A: The ingredients 1 and 2 are uniformly mixed at room temperature. B: Add the ingredients 3 to 6 and 7 to A ' and mix them evenly. C: Fill the B The container was obtained as a hair cosmetic (hair care essence). The results of the evaluation of the hair cosmetic (hair care essence) of Example 9 in the same manner as in Example 3, the stability over time It is excellent in all aspects of affinity for hair, penetration, and moisturizing feeling. Example 10: Cosmetics for hair (fogging) -40- 201113045 (ingredient) 1. Base composition of Example 6. Hydrolysis Collagen solution 3. Purified water (%) 1 Residual amount (manufacturing method) A: Components 1 to 3 were uniformly mixed at room temperature. B: A was filled into a spray container to obtain a cosmetic for hair. In the same manner as in Example 3, the results of the evaluation of Example 1 〇 &lt;hair (fogging) were excellent in terms of stability, affinity, penetration, and moisturization feeling over time. Example of applying makeup to hair η : Body moisturizing cosmetic (ingredient) 1 · Base composition of the present invention 4 2. L-theanine 3 · Sodium hyaluronate (1% aqueous solution) 4. Refined water (%) 0.5 〇.1 5.0 Residual amount (manufacturing method) Α : The components 1 to 4 are uniformly mixed at room temperature. Β : Fill the 塡 to the container to get a moisturizing cosmetic for the body. The results of the evaluation of the body-protected-41 - 201113045 wet cosmetic of Example n in the same manner as in Example 3, the stability over time, the affinity for the skin, the feeling of penetration, and the moisturizing feeling were all aspects. All are excellent. BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a photograph of a substrate composition of the present invention 1 observed by a transmission electron microscope. Fig. 2 is a photograph showing the presence of a Maltese cross-shaped image (indicator of formation of a substrate) under a positive polarized microscope for a base composition of the present invention 1 under a polarizing microscope. Figure 3 is a photograph of a cross-section of the hair that assesses the permeability to the interior of the hair. Fig. 3-1: Photograph of the cross-section of the hair immersed in the sample of the product 5 of the present invention. Figure 3-2: Photograph of the cross-section of the hair immersed in the sample of Comparative Product 2 (with no fluorescent label added). Fig. 3 - 3: Photograph of the cross-section of the hair immersed in the sample of Comparative Product 3. Fig. 3 - 4: A cross-sectional photograph of the hair immersed in the sample of Comparative Product 4. Fig. 4 is a graph showing the results of evaluation of the ratio of bound water in the hair of the sample of the product 5 of the present invention. Figure 5 is a graph showing the evaluation of the stability of the substrate composition containing dipalmitole ethyl hydroxyethyl methyl ammonium sulfate (Deq) over time. Fig. 6 is a result of evaluation of the stability of the substrate composition containing distearyl dimethyl ammonium chloride (d S A C ) over time. Figure 7 is a graph showing the results of differential scanning calorimetry (DSC) measurement of a substrate composition containing dipalmitole ethyl hydroxyethyl methyl ammonium sulfate (DEQ). -42-

Claims (1)

201113045 VII. Patent application scope: 1. A base composition characterized by containing the following components (A) to (c) (A) a cationic surfactant represented by the following general formula (1), [Chemical 4] ] R1CO— CH3 〇4CH2)—N+~-{cH2)^-〇-COR2 X (1) (where Rko-, R2CO- are the same or different, representing 8 to 22 saturated or unsaturated fats) R3 represents -CH3' or -CH2〇H, or _C2H4OH; m, n are the same or different, meaning 2 or 3; x means halogen, methyl sulfate, ethyl sulfate or phosphate Vinegar); (B) sterols; (C) water. 2. The base composition of claim 3, wherein the molar ratio (A)/(B) of the component (A) to the component (B) is in the range of 100/1 to 1/4. 3. The base composition of claim 2 or 2, wherein the component (B) is cholesterol and/or phytosterol. A cosmetic composition characterized by adding a base composition according to any one of claims 1-3. 5. A cosmetic according to item 4 of the patent application, which is for hair. 6. A cosmetic according to claim 4 or 5, wherein a monovalent lower alcohol is further added as the component (D). -43-