KR20120039619A - Vesicle composition and cosmetic comprising same - Google Patents

Abstract

An object of this invention is to provide the vesicle composition which was excellent in stability with time, and the cosmetics which mix | blended it.
In order to solve the said subject, a vesicle composition and the cosmetics which mix | blended it are following components (A)-(C); It is characterized by containing (A) cationic surfactant represented by a specific formula, (B) sterols, and (C) water.

Description

Vesicle composition and cosmetic composition same

TECHNICAL FIELD The present invention relates to a vesicle composition having excellent stability over time, comprising a specific cationic surfactant, sterols, and water as a component, and a cosmetic composition containing the same, in particular, as a cosmetic for hair blended with the composition, In the case of the present invention, the present invention relates to a cosmetic for hair, which adheres quickly to hair, has excellent permeability into the hair, and is excellent in imparting a moist feeling.

Background Art Conventionally, sterols such as cholesterol and phytosterol are effective ingredients for hair, and a compounding review has been made on hair cosmetics. In particular, cholesterol is originally present in hair as a component of hair's water retention and retention function, but its content is known to decrease around 10 years of age (see Non-Patent Literature 1). It is one of the important ingredients for maintaining beautiful hair.

However, sterol derivatives such as cholesterol are generally known as poorly soluble substances which are difficult to be dissolved in both water and oil (see Patent Document 1). In particular, it is very stable to mix them in a lotion-based formulation using water as a medium. It is difficult. For this reason, various studies of the technique which mix | blend these poorly water-soluble sterol derivatives with cosmetics of an aqueous medium stably are performed.

For example, by mixing a quaternary alkylammonium salt type cationic surfactant, both lipophilic substances, sterol derivatives and water in a specific mixing ratio, a two-molecular film vesicle of a lamellar liquid crystal containing an aqueous phase, namely It is known that a vesicle is formed (refer patent document 2).

Moreover, as a further examination, a vesicle is formed by mix | blending a cationic polymer (refer patent document 3) and silicone (refer patent document 4) to a quaternary alkylammonium salt type cationic surfactant, a sterol derivative, and a ceramide. Known.

Moreover, there exists an example which mixed sterols, such as cholesterol, using dicoylethylhydroxyethylmonium metosulfate which has an ester structure in a hydrophobic group as a cationic surfactant different from the said patent documents 2-4 (refer patent document 5). ).

[Non-Patent Document 1] Journal of Cosmetic Products and Technology (Vol. 13 No. 3 1989 p. 134-p. 139)

[Patent Document 1] Japanese Patent Laid-Open No. 2006-176410

[Patent Document 2] Japanese Patent Application Laid-Open No. 2001-97811

[Patent Document 3] Japanese Patent Laid-Open No. 2006-199634

[Patent Document 4] Japanese Patent Publication No. 2006-199635

[Patent Document 5] Japanese Patent Publication No. 2006-182743

However, all the techniques of patent documents 2-4 used the quaternary alkylammonium salt type | mold cationic surfactant, and when the quaternary alkylammonium salt type | mold cationic surfactant was used, when the vesicles of sterols are not fully performed In some cases, the stability of the vesicles may be insufficient, such as destruction of the vesicles, precipitation, crystallization, and precipitation. In addition, even if such a vesicle is blended into the cosmetic for hair and applied to the hair, the feeling of being in close contact with the hair and penetrating into the hair; There existed a problem that a penetration feeling was hard to be obtained and a moist feeling was also hard to obtain.

Moreover, according to patent document 5, flame retardant components, such as cholesterol, cannot be mix | blended stably in a vesicle, and for this reason, there existed a problem that cholesterol or the like precipitated over time, and it is difficult to bring about an effective effect on hair. .

Therefore, an object of this invention is to provide the vesicle composition which can stably mix | blend sterols, such as cholesterol which is an effective component for hair, with an aqueous medium, and is excellent in stability with time, and the cosmetics which mix | blended it. In particular, when applied to hair as a cosmetic for hair blended with the composition, the object of the present invention is to provide a cosmetic for hair that is in close contact with the hair quickly, excellent in permeability into the hair, and excellent in imparting a moist feeling.

MEANS TO SOLVE THE PROBLEM As a result of earnestly researching in order to solve the said subject, by combining a cationic surfactant which has a specific chemical structure, sterols, and water, the vesicle composition excellent in time-lapse stability is obtained, and the composition is water-based. It can be stably blended into the cosmetics of the cosmetics. In addition, when it is blended into the cosmetics for hair and applied to the hair, the cosmetics adhere quickly without remaining on the surface of the hair forever, and have excellent penetration into the hair. This penetrating feeling can be realized and the hair cosmetics excellent in the moist feeling provision effect were obtained, and the present invention was completed.

That is, this invention is the following component (A)-(C),

(A) Formula 1

(In the formula, R ¹ CO-, R ² CO- is, the same or different and are O with a carbon number of 8 to 22 saturated or unsaturated aliphatic group, R ³ is -CH _3, or -CH ₂ OH, or -C ₂ H ₄ OH, m, n are the same or different, and 2 or 3, X represents halogen, methosulfate, ethosulfate or metophosphate)

(B) sterols

(C) water

It is to provide a vesicle composition comprising a.

Moreover, this invention provides the vesicle composition characterized by the molar ratio (A) / (B) of a component (A) and a component (B) being in the range of 100/1-1/4.

The present invention also provides a vesicle composition characterized in that component (B) is cholesterol and / or phytosterol.

Moreover, this invention provides the cosmetics characterized by mix | blending the said vesicle composition. The preferable aspect of the cosmetics of this invention is hair cosmetics.

Furthermore, this invention mix | blends monovalent lower alcohol as a component (D) further with the said vesicle composition or the said cosmetics, It is characterized by the above-mentioned.

The vesicle composition of this invention is excellent in stability with time, and can be mix | blended stably with cosmetics. In particular, the hair cosmetics blended with the above composition, when applied to the hair, adheres quickly to the hair, has excellent permeability into the inside of the hair, realizes a feeling of penetrating, and is excellent in imparting a moist feeling.

1 is a photograph of the vesicle composition of the present invention 1 observed with a transmission electron microscope.
FIG. 2 is a photograph of observation of a presence of a Maltese Cross on the vesicle composition of the Invention 1 under an orthogonal nicotine, indicating that the vesicle is formed.
3 is a photograph of a cross section of hair which evaluates the penetration into the hair.
3-1: Photograph of the cross section of hair immersed in the sample of the invention 5; 3-2: Photograph of the cross section of the hair immersed in the sample of Comparative Product 2 (fluorescent marker not added). Fig. 3-3: Photograph of the cross section of hair immersed in the sample of Comparative Product 3. 3-4: Photograph of the cross section of the hair immersed in the sample of Comparative Product 4.
It is a graph which shows the result of evaluating the coupling | bonding water ratio in the hair of the sample of this invention 5.
5 is a result of evaluating the stability over time of the vesicle composition containing dipalmitoylethylhydroxyethylmonium methosulfate (DEQ).
6 is a result of evaluating the stability over time of the vesicle composition containing distearyl dimethylammonium chloride (DSAC).
7 is a differential scanning calorimetry (DSC) measurement result of a vesicle composition containing dipalmitoylethylhydroxyethylmonium metosulfate (DEQ).

This invention is demonstrated in detail.

This invention relates to the vesicle composition containing predetermined component (A)-(C).

In addition, in this specification, a "vesicle composition" means a spherical closed vesicle in water, and the maltide cross phase is observed by polarizing microscope observation, and as another observation method, it is a transmission electron microscope observation of a multilayer structure. It means that a multilamella vesicle is observed.

The cationic surfactant of component (A) used for this invention is following General formula (1).

[Formula 1]

(In the formula, R ¹ CO-, R ² CO- is, the same or different and are O with a carbon number of 8 to 22 saturated or unsaturated aliphatic group, R ³ is -CH _3, or -CH ₂ OH, or -C ₂ H ₄ OH, m, n are the same or different, and 2 or 3, X represents halogen, methosulfate, ethosulfate or metophosphate). It is a main component of the two-molecule film forming a vesicle. It has an ester bond in a hydrophobic chain (also called an ester quart), and generally, compared with the long-chain alkyl type cationic surfactant of the same carbon number, it is excellent in the hair conditioning effect and also excellent in biodegradability.

In the present invention, by using the component (A), the stability over time is excellent, and the microscopic film fluidity (hereinafter, abbreviated as "vehicle deformability") that evaluates the deformability of the bimolecular film in the vesicle structure is also excellent. Since the vesicle composition can be prepared, when the component (B) described later is contained in the vesicle formed by the component (A), there are no cases where hair active ingredients such as the component (B) are precipitated over time. It can be held and maintained stably. And when it apply | coated to hair, it penetrates efficiently to the inside of hair, the hair effective component, such as a component (B), is delivered to the inside of hair stably, and the thing with high effect which gives a moist feeling is obtained.

Specific examples of the component (A) include dicoylethylhydroxyethylmonium methosulfate, distearoylethylhydroxyethylmonium methosulfate, dipalmitoylethylhydroxyethylmonium methosulfate, and the like. Alternatively, two or more kinds thereof may be used in combination, and commercial products such as DEHYQUART L80, DEHYQUART F75, DEHYQUART AU56 / G, and DEHYQUART C4046 (all manufactured by Cognis) may be used. Among them, dicoylethylhydroxyethylmonium metosulfate is particularly preferable from the viewpoint of the stability of the vesicle composition obtained over time and the permeability (permeability) when the hair cosmetic composition containing the vesicle composition is applied to the hair. .

Although the compounding quantity in the vesicle composition of the component (A) of this invention is not specifically limited, 0.001-10 mass% (it abbreviates to only "%" hereafter) is preferable, and its 0.01-5% is more preferable.

If the blending amount is within this range, a vesicle composition excellent in aging stability and deformability of the vesicle film is obtained. Thus, when it is blended into a cosmetic, it is very stable until use, for example, when applied to hair, Hair active ingredients, such as B), penetrate efficiently inside the hair, and the thing excellent in the moist feeling is obtained.

Sterols of the component (B) used in the present invention contribute to the formation and stabilization of the vesicle, and also contribute to impart the moist feeling to the hair when the obtained vesicle composition is blended into the cosmetic for hair. do.

For example, when sterols are added to a vesicle system containing a distearyl dimethylammonium chloride (Lion-Arc Irradiation Co., Ltd.) having a long-chain alkyl group containing no ester group as a conventionally used cationic surfactant, The vesicle system may cause aggregation or the like. However, when sterols are added to the vesicle system including the cationic surfactant represented by the above formula (1) containing a long chain alkyl chain containing an ester group, unexpectedly stabilizing the vesicle system is unexpected. Discovered by the inventor.

The sterols of component (B) may be any substance or derivative thereof having a sterol skeleton, for example, cholesterol, phytosterol (β-sitosterol, camphorsterol, stigmasterol, brassicasterol, etc.), lanosterol, Polyoxyethylene cholesteryl ether, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, palm oil fatty acid cholesteryl, oleic acid phytosteryl, N-lauroyl-L-glutamic acid di (cholesteryl? Behenyl-octyldodecyl), N-lauroyl-L-glutamic acid di (octyldodecyl phytosteryl? Behenyl), N-lauroyl-L-glutamic acid di (phytosteryl-octyldodecyl) , Phytosteryl oleate, and the like, and one or two or more of these may be used. Among these, the sterol skeleton represented by the following general formula (2), and R is an aliphatic group (for example, linear or Branched alkyl groups, Is a sterol straight chain or branched chain alkenyl group) is preferred and, in particular, preferred are cholesterol, phytosterol.

As a commercial item, Nissui Marine Cholesterol (made by Nippon Suisan Co., Ltd.), Marine Cholesterol (manufactured by Kyowa Technos Co., Ltd.), Phytosterol (manufactured by Ezai Food Chemical Co., Ltd.), Rice sterol (manufactured by Tsuno Rice Fine Chemicals, Inc.), EMALEX CS-10 (Made by Nihon Emulsion Co., Ltd.), Eldura PS-203, Eldura PS-304, Eldura PS-306 (above, manufactured by Ajinomoto Co., Ltd.) and the like can be used.

Although the compounding quantity of the component (B) of this invention is not specifically limited, 0.001-5% is preferable in a vesicle composition, and 0.01-3% is more preferable. When used in this range, since the vesicle composition is formed satisfactorily, the stability over time is excellent, and the component (B) effectively penetrates into the hair, a sufficient moist feeling can be felt.

Moreover, as for the compounding ratio of component (A) and component (B) of this invention, the molar ratio (A) / (B) of component (A) with respect to component (B) has preferable 100/1-1/4, 9 It is more preferable to exist in the range of 1-3. When the molar ratio of (A) / (B) is within this range, the microfluidic membrane fluidity (deformation of the vesicle membrane) is excellent, resulting in a vesicle composition with excellent stability over time, and effectively the component (B) effective for hair It can penetrate into hair inside and can exhibit the effect of component (B) better.

The water of component (C) used in the present invention is used as a dispersion medium of the vesicle, and is an essential component as the vesicle composition and the medium of the cosmetic compound containing the same. Although the compounding quantity is suitably determined according to the quantity of another component, ie, a component (A), (B), or a component (A), (B), the component (D) mentioned later, and the component mix | blended arbitrarily, it is about 5- It can be used in the range of 99%, more preferably 20 to 90%, and still more preferably 60 to 90%.

In addition to the above-mentioned components (A)-(C), the vesicle composition of this invention can mix | blend a liquid higher fatty acid at 25 degreeC in order to further improve stability with time to crystallization of a component (B). . Any liquid higher fatty acid may be used at 25 ° C. Examples thereof include saturated branched fatty acids such as isomilistic acid, isopalmitic acid and isostearic acid, and unsaturated fatty acids such as oleic acid and linoleic acid. Further, vegetable oils containing unsaturated fatty acids include avocado oil, almond oil, refined jojoba oil, grape seed oil, sesame oil, wheat germ oil, rice bran oil, soybean oil, corn germ oil, rapeseed oil, macadamia nut oil, meadowfoam oil and peanut oil. Or rose hip oil. As content of the liquid higher fatty acid in 25 degreeC, 0.5-1.5 times as a mass ratio with respect to a component (B) is mentioned as a preferable thing.

Although it does not specifically limit as a manufacturing method of the vesicle composition of this invention, For example, the component (A) and (B) heated at 100 degreeC or more are disperse | distributed to the component (C) heated at 90 degreeC or more, It is obtained by gradually cooling to room temperature while continuing stirring after that. In addition, you may add the component which can be mix | blended arbitrarily as mentioned later in anticipation of the usability, the further effect to a hair | hair, etc. suitably according to the property, etc. at the time of vesicle preparation.

Although the average particle diameter of the obtained vesicle composition is about 100 nm-10 micrometers, Preferably, when a mean particle diameter is 50-500 nm using apparatuses, such as an extruder mentioned later, a vesicle may collapse even over time. There is no change and the change (increase) of the average particle diameter is excellent.

The vesicle composition of this invention prepared by the said method etc. can mix | blend this with various cosmetics, such as hair cosmetics. In particular, the hair cosmetics to which the vesicle composition of the present invention is blended are preferred because of their excellent penetration into the hair.

This invention relates also to the cosmetics which mix | blended the vesicle composition of this invention. The lower monohydric alcohol can be mix | blended with the cosmetics which mix | blended the vesicle composition of this invention as a component (D).

Although the lower monohydric alcohol of component (D) is a component which is important in showing the drying speed and refreshing feeling at the time of application | coating generally in hair cosmetics, and contributes to the favorable adhesiveness to hair, In order to mix | blend a lower monohydric alcohol, it is known as making it difficult to ensure stability with time.

However, in this invention, even if it mix | blends the lower monohydric alcohol of component (D) by using the said component (A), the thing with favorable stability over time is obtained, and this vesicle composition is mix | blended. When a cosmetic for hair is applied to hair, it adheres quickly, is excellent in the permeability into the inside of hair, the permeability of an active ingredient can be realized, and the favorable thing with the high effect which gives a moist feeling is obtained.

The lower monohydric alcohol of component (D) can be used without particular limitation as long as it is used in cosmetics in general, and ethyl alcohol, propyl alcohol, isopropyl alcohol, and the like can be cited. In the present invention, ethyl alcohol is preferable.

Although the compounding quantity of the component (D) of this invention is not specifically limited, Although it determines suitably according to the characteristic requested | required as target quality of the cosmetics to prepare, for example, adhesiveness, permeability into hair inside, etc., it is about 0.1 in the cosmetics whole quantity. -30% is preferable, 1-30% is more preferable, 1-25% is more preferable, 5-20% is still more preferable.

Although it does not specifically limit as a manufacturing method of the cosmetics of this invention, For example, after disperse | distributing component (A) and (B) to component (C) as mentioned above, it cools to room temperature and prepares a vesicle composition It can manufacture by the method containing mix | blending a component (D), arbitrary components mentioned later, etc. with the thing and this vesicle composition. Arbitrary components mix | blended are mix | blended in anticipation of the usability, the further effect on hair, etc.

By blending the vesicle composition of the present invention into a cosmetic for hair, the active ingredient such as component (B) is superior to the hair cosmetic formulated without formulating a vesicle, and is excellent in stability over time, and furthermore, inside the hair at the time of use. The favorable thing with the high effect of giving a moist feeling excellent in the permeability of a furnace and the perception of permeation feeling is obtained.

Especially in the cosmetics which mix | blended the component (D), although a component (D) is a component which tends to make it difficult to ensure stability over time, a good time-lapse stability is mix | blended by mix | blending the vesicle composition of this invention. In addition, in the aspect of the cosmetic for hair, for example, it can be made to be in close contact with the hair quickly, excellent in permeability into the inside of the hair, excellent in permeability, and excellent in imparting a moist feeling.

The compounding quantity of the cyclicle composition with respect to the cosmetics of this invention is not specifically limited, 0.5% or more are preferable and 10% or more of a cosmetic whole quantity is more preferable. It is also possible to use the vesicle composition of the present invention as it is as a 100% cosmetic.

There is no restriction | limiting in particular about the formulation of the cosmetics of this invention, From a viewpoint of maintaining a vesicle stably, it is preferable to prepare as a cosmetic of the formulation of which the external wound is aqueous system. The external wound may contain various agents (eg, ethyl alcohol, polyhydric alcohols, salts, surfactants, etc.) that can be dissolved and / or dispersed in water, in addition to water.

In addition to the components (A) to (C) and the component (D), the vesicle composition of the present invention and the cosmetic composition containing the same, an oil agent, a surfactant, and an alcohol other than these in a range that does not impair the effects of the present invention. Hair, such as metal soaps, gelling agents, powders, water-soluble polymers, film-forming agents, resins, humectants, antibacterial agents, fragrances, deodorants, salts, pH adjusters, fresheners, ultraviolet absorbers, plant extracts, amino acids, sugars, vitamins, etc. Care beauty component etc. can be mix | blended.

Examples of the oil agent include liquid, paste and solid hydrocarbons, waxes, esters, and fatty acids at room temperature (the higher fatty acids may be liquid at 25 ° C or may be non-liquid higher fatty acids at 25 ° C). Oily components, such as these, can be used. Specifically, for example, hydrocarbons, fats and oils, waxes, hydrogenated oils, ester oils, fatty acids, silicone oils, fluorine-based emulsions, lanolin derivatives, and the like can be used. More specifically, for example, ozoke Hydrocarbons such as light, ceresin, paraffin, paraffin wax, microcrystalline wax, waxes such as myristic acid cetyl and cetyl palmitate, petroleum jelly, liquid paraffin, pristane, polyisobutylene, squalane, squalene and liquid paraffin Waxes such as waxes, beeswax, carnauba wax, candelilla wax and spermatozoon, solid oils such as cetyl alcohol, stearyl alcohol, cetostearyl alcohol, behenyl alcohol and shea butter, tallow, Animal oils such as right angled paper, right bone, hardened beef, hardened oil, turtle oil, pork fat, marzipan, mink oil, liver oil, egg yolk oil, palm oil , Olive oil, rice germ oil, rice bran oil, castor , Plant oils such as macadamia nut oil, olive oil, almond oil, avocado oil, camellia oil, rosehip oil, safflower oil, sunflower oil, liquid wax such as jojoba oil, isopropyl myristic acid, butyl myristic acid, iso palmitate Propyl, ethyl oleate, cetyl caprate, hexyl laurate, decyl oleate, oleic oleate, isostearyl laurate, isostearyl myristate, isosetyl myriate, octylate octylate, arm 2-ethylhexyl methane, isocetyl palmitate, 2-ethylhexyl stearate, isocetyl stearate, isodecyl oleate, octyl oleate oleate, 2-ethylhexanoate cetyl, 2-ethylhexanoate cetostearyl, Hexyl isostearate, octyldodecyl neopentanoate, isostearyl octanoate, 2-ethylhexyl isofellargonate, hexyl dimethyl octanate, octyl dodecyl dimethyl octanate, 2-ethylhexyl isopalmitate, isostear Isocetyl acid Isostearyl stearate, isononyl isononate, ethylene glycol dioctanoate, propylene glycol dicapric acid, neopentyl glycol dioctanoate, glyceryl tricaprate, glyceryl tri2-ethylhexanoate, triisostearic acid Ester oils such as glyceryl, tri2-ethylhexanoic acid trimethylolpropane, triisostearic acid trimethylolpropane, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, oleic acid, linoleic acid And fatty acids such as arachidonic acid, docosahexaenoic acid (DHA), 12-hydroxystearic acid, isostearic acid and 2-ethylhexanoic acid, silicone oils such as dimethylpolysiloxane and methylphenylpolysiloxane, and perfluorodecane Lanolin derivatives such as fluorine oil, lanolin, liquid lanolin, reduced lanolin, lanolin alcohol, hard lanolin, lanolin acetate, lanolin fatty acid isopropyl, and the like.

As surfactant, any of anionic, cationic, amphoteric, and nonionic may be sufficient, and as anionic surfactant, fatty acid soaps, such as sodium stearate and triethanolamine, alkyl ether carboxylic acid, its salt, and amino acid Carboxylates such as condensation of fatty acids with alkylsulfonates, alkenesulfonates, sulfonates of fatty acid esters, sulfonates of fatty acid amides, sulfonates of alkylsulfonates and their formalin condensates, alkylsulphate ester salts, secondary grades Sulfuric acid ester salts, alkyl and allyl ether sulfate salts, sulfate ester salts of fatty acid esters, sulfate ester salts of fatty acid alkylolamides, sulfate ester salts such as lot oils, alkyl phosphates, ether phosphates, alkyl allyl ether phosphates, and amide phosphates And N-acylamino acid activators.

Examples of the cationic surfactants include amine salts such as alkylamine salts, polyamines and aminoalcohol fatty acid derivatives, alkyl quaternary ammonium salts, aromatic quaternary ammonium salts, pyridinium salts, and imidazolium salts other than component (A). .

Betaine, aminocarboxylate, imidazoline derivative, etc. are mentioned as an amphoteric surfactant.

As the nonionic surfactant, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerol fatty acid ester, propylene glycol fatty acid ester, polyethylene glycol fatty acid ester, sucrose fatty acid ester, polyoxyethylene alkyl ether, polyoxypropylene alkyl ether, polyoxyethylene alkyl Phenyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene propylene glycol fatty acid ester, polyoxyethylene castor oil, polyoxyethylene hardened castor Free, polyoxyethylene phytostanol ether, polyoxyethylene phytosterol ether, polyoxyethylene choletanol ether, polyoxyethylene cholesteryl ether, polyoxyalkylene modified organo Polysiloxane, polyoxyalkylene-alkyl co-modified organopolysiloxane, lauric diethanolamide, palm oil fatty acid diethanolamide, palm oil fatty acid monoethanolamide, polyoxyethylene palm oil fatty acid monoethanolamide, lauric acid monoisopropanolamide, palm oil fatty acid Monoisopropanolamide, sugar ether, sugaramide and the like.

As alcohol, what is necessary is just what is other than a component (D), and glycerin, diglycerol, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1, 3- butylene glycol, 1, 2- pentane Polyhydric alcohols such as diol and polyethylene glycol.

Examples of the metal soap include 12-hydroxyaluminum stearate, zinc stearate, aluminum stearate, calcium stearate, magnesium stearate, zinc myristate, myristic acid magnesium, cetyl phosphate, calcium cetyl phosphate and zinc sodium cetyl phosphate. And zinc laurate and zinc undecylenate.

Examples of the gelling agent include amino acid derivatives such as N-lauroyl-L-glutamic acid and α, γ-di-n-butylamine, dextrin palmitic acid esters, dextrin stearic acid esters, dextrin 2-ethylhexanoic acid palmitic acid esters, and the like. Sucrose fatty acid esters such as non-texturic fatty acid esters, sucrose palmitic acid esters, sucrose stearic acid esters, benzylidene derivatives of sorbitol such as monobenzylidene sorbitol, dibenzylidene sorbitol, dimethylbenzyldodecylammonium montmorillonite clay, dimethyl diocta Organic modified clay minerals, such as decylammonium montmorillonite clay, etc. are mentioned.

As a powder, if it is used for normal cosmetics, irrespective of the shape (spherical shape, needle shape, plate shape, etc.), particle diameter (fog shape, fine particle, pigment grade etc.), particle structure (porous, nonporous etc.), Any may be used. For example, as the inorganic powder, magnesium oxide, barium sulfate, calcium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, talc, synthetic mica, mica, kaolin, sericite, mica, synthetic mica, gold Mica, red mica, biotite, lithia mica, silicic acid, silicic anhydride, aluminum silicate, magnesium silicate, magnesium aluminum silicate, calcium silicate, barium silicate, strontium silicate, metal tungstate salt, hydroxyapatite, vermiculite, hydrite, montmorillonite, zeolite Ceramic powder, dicalcium phosphate, alumina, aluminum hydroxide, boron nitride and the like; Examples of the organic powder include polyamide powder, polyester powder, polyethylene powder, polypropylene powder, polystyrene powder, polyurethane, benzoguanamine powder, polymethylbenzoguanamine powder, tetrafluoroethylene powder, polymethylmethacrylate powder, Cellulose, silk powder, nylon powder, 12 nylon, 6 nylon, styrene acrylic copolymer, divinyl benzene styrene copolymer, vinyl resin, urea resin, phenol resin, fluorine resin, silicon resin, acrylic resin, melamine resin, epoxy Resins, polycarbonate resins, microcrystalline fiber powder, laurolysine and the like; Examples of the colored pigments include inorganic red pigments such as iron oxide, iron hydroxide and iron titanate, inorganic brown pigments such as γ-iron oxide, inorganic yellow pigments such as iron sulfate and ocher, inorganic black pigments such as iron oxide and carbon black, manganese violet, Inorganic purple pigments such as cobalt violet, Inorganic green pigments such as chromium hydroxide, chromium oxide, cobalt oxide, cobalt titanate, Inorganic blue pigments such as blue blue and ultramarine, Tar-based pigments, Lake naturalized One, and a composite powder obtained by complexing these powders; Examples of the pearl pigment include titanium oxide coated mica, titanium oxide coated mica, bismuth oxychloride, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, young foil, titanium oxide coated colored mica, and the like; Examples of the metal powder pigments include aluminum powder, copper powder, stainless steel powder, and the like; As tar dye, red 3, red 104, red 106, red 201, red 202, red 204, red 205, red 220, red 226, red 227, red 228, red 230 Arc, red 401, red 505, yellow 4, yellow 5, yellow 202, yellow 203, yellow 204, yellow 401, blue 1, blue 2, blue 201, blue 404, Green 3, green 201, green 204, green 205, orange 201, orange 203, orange 204, orange 206, orange 207, and the like; The natural pigment may be a powder selected from carmic acid, laccaic acid, cartamine, braziline, crosine, or the like, and may be a powder obtained by complexing these powders or surface treatment with an emulsion, silicone, or fluorine compound.

Water-soluble polymers include gum arabic, tragacanth, galactan, carob gum, guar gum, karaya gum, carrageenan, pectin, agar, queen's seed, algae colloid, transgum gum and locust bean gum. , Plant-based polymers such as galactomannan, microorganism-based polymers such as xanthan gum, dextran, succinoglucan, and pullulan, starch-based polymers such as starch, carboxymethyl starch, methylhydroxypropyl starch, methyl cellulose and ethyl cellulose Methyl hydroxypropyl cellulose, carboxymethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, nitrocellulose, sodium cellulose sulfate, sodium carboxymethyl cellulose, crystalline cellulose, cellulose polymer of cellulose powder, sodium alginate, propylene glycol ester, etc. Alginic acid polymer, polyvinyl methyl ether, carboxyvinyl poly Vinyl polymers such as mercury, alkyl-modified carboxyvinyl polymers, polyoxyethylene polymers, polyoxyethylene polyoxypropylene copolymer-based polymers, acrylic polymers such as sodium polyacrylate, polyethylacrylate and polyacrylamide, polyethyleneimine and cations Inorganic water-soluble polymers such as polymer, bentonite, laponite, hectorite and the like. In addition, these include film forming agents such as polyvinyl alcohol and polyvinylpyrrolidone.

Examples of the moisturizing agent include mucopolysaccharides such as chondroitin sulfate, hyaluronic acid, mucin, dermatan sulfate, heparin, keratan sulfate, proteins such as soy protein, wheat protein, derivatives thereof, collagen, elastin, keratin, and the like. Can be mentioned.

Examples of the antimicrobial agents include benzoic acid, sodium benzoate, salicylic acid, phenol, sorbic acid, potassium sorbate, paraoxybenzoic acid ester, parachloromethcresol, hexachlorophene, benzalkonium chloride, chlorhexidine, trichlorocarbanilide, photosensitizers, bis (2-pyridylthio-1-oxide) zinc, phenoxyethanol, isopropylmethylphenol, etc. are mentioned.

As a ultraviolet absorber, For example, as a benzophenone system, 2-hydroxy-4- methoxy benzophenone, 2-hydroxy-4- methoxy benzophenone-5-sulfonic acid, and 2-hydroxy-4- methine Oxybenzophenone-5-sodium sulfonate, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone-5- Sodium sulfonate, 2,4-dihydroxybenzophenone, 2,2 ', 4,4'-tetrahydroxybenzophenone, and the like. Examples of the PABA system include paraaminobenzoic acid, ethyl paraaminobenzoic acid, and paraamino. Glyceryl benzoyl, paradimethylamino benzoic acid amyl, paradimethylamino benzoic acid-2-ethylhexyl, paradihydroxypropyl benzoic acid ethyl, and the like. Examples of cinnamic acid include p-methoxy cinnamic acid-2-ethylhexyl and 4-methic. And ethoxy cinnamic acid-2-ethoxyethyl and the like. Examples of the salicylic acid system include salicylic acid-2-ethylhexyl, phenyl salicylate, and salicylic acid homomentyl. There may be mentioned 2- (2-hydroxy-5-methylphenyl) benzotriazole, 4-tert- butyl-4'-methoxy benzoyl methane CD, oxybenzone.

Examples of the pH regulator include lactic acid, citric acid, glycolic acid, succinic acid, tartaric acid, malic acid, phosphoric acid, salts thereof, potassium carbonate, sodium bicarbonate, ammonium bicarbonate, and the like. have.

As plant extracts, birch, hamamelis, sage, hop, rosemary, rose, orange, asparagus, bitter grass, golden, honeysuckle, perilla, red pepper, sancho, nettle, tea, ginseng, soap grass, beech tail, grape And extracts of plants and herbal medicines such as seaweed, soybeans and saplings.

Examples of the amino acids include glycine, proline, isoleucine, histidine, alanine, arginine, lysine, serine, cysteine, acetylcysteine, and the like.

Examples of the sugars include glucose, fructose, galactose, mannitol and sorbitol.

As vitamins, Vitamin F, such as vitamin A and its derivatives, vitamin B and its derivatives, vitamin C and its derivatives, vitamin E and its derivatives, linolenic acid and its derivatives; Vitamin K, such as phytonadione, menaquinone, menadione, and menadiol; Vitamin Ps such as erythrocirine and hesperidin; Others include biotin, cartinine, ferulic acid and the like.

Cosmetics, such as the hair cosmetics which mix | blended the vesicle composition of this invention, can be prepared without a restriction | limiting in particular in liquid form, an emulsion form, cream form, gel form, etc., For example, hair lotion, hair milk, hair cream And hair cosmetics such as out bath hair products such as hair treatments and cracked hair coatings, and in bath hair products such as rinses, hair packs, and shampoos. Moreover, it can also implement as an aerosol hairspray or a hair foam by mix | blending a propellant. It is especially effective in formulations, such as a hair lotion which mix | blended the component (D), such as ethyl alcohol. That is, in the case of the formulation which mix | blended component (B) with an emulsion composition normally, when the compounding quantity of component (D) increases, it becomes difficult to mix stably, but in the case of the formulation which used the vesicle composition of this invention, While ensuring stability over time, it becomes excellent in the adhesiveness to hair, and the favorable thing which sets it as the structure of this application is fully exhibited.

The cosmetics which mix | blended the component (D) are disperse | distributed components (A) and (B) to component (C) as mentioned above, for example, cooling to room temperature, and preparing the vesicle composition, the It is obtained by the method including adding component (D) to a composition. In addition, similar to the preparation of the vesicle composition, the above-mentioned optional components can be appropriately added according to their properties and the like, in anticipation of a feeling of use and additional effects on hair, and the like.

[ Example ]

Next, an Example is given and this invention is demonstrated in detail. In addition, these do not limit this invention at all.

Example 1 (Invention 1 and Comparative Product 1): Vacicle Composition

According to the prescription shown in the following table | surface and the following manufacturing method, the vesicle composition (Invention 1) using the component (A) of this invention, and a general long-chain quaternary alkylammonium salt type cationic surfactant instead of component (A) The vesicle composition (Comparative article 1) using the above was prepared, and it was confirmed that a vesicle was produced by the following method, and the stability over time was further evaluated by the change of the vesicle (average particle size). In addition, the quaternary alkylammonium salt type | mold cationic surfactant used by the comparative product 1 is distearyl dimethyl ammonium chloride ("Acad 2HP-75" lion-arc irradiation manufacture).

<Confirmation of vesicle generation>

A polarizing microscope (Olympus DP-70) was observed under orthogonal nicotine to confirm the presence of the vesicle (the presence of a maltide cross on which the vesicle was formed). In addition, a transparent electron microscope (HITACHI H-7650 pressurized voltage: 80 kPa) was used for the obtained vesicle composition (negative staining by adding an equal amount of aqueous 1% phosphorous tungstic acid solution to a 10-fold dilution dispersion of purified water). Observed. The production of vesicles can be confirmed using the formation of a multilamella vesicle having a multilayer structure as an index.

In the present invention 1, a large number of Maltese cross images, which are indicative of the formation of vesicles, were observed by observation of a polarizing microscope, and a multilamella vesicle having a multilayer structure was observed by observation of a transmission electron microscope. .

About the invention 1, the photograph observed with the transmission electron microscope in FIG. 1, and the photograph observed with the polarizing microscope are shown in FIG.

(Manufacturing method)

A: The components 1-3 are melt | dissolved by heating at 100 degreeC.

B: Component 4 is heated to 90 ° C.

C: A is added to B and mixed and stirred with a homomixer.

D: C was cooled to room temperature to obtain a vesicle composition.

<Evaluation of Stability Over Time>

As an evaluation of the stability over time, changes in the average particle diameter and state of the vesicles were measured (observed) over time by the following method, and further determined using the following criteria. The results are shown together in the table above.

(Assessment Methods)

The vesicle composition of this invention 1 and the comparative product 1 was heated at 60 degreeC, and the inside of the extruder (made by Avanti Polar Lipids) equipped with the PC membrane (pore size: 200 nm WHATMAN company) was carried out under 60 degreeC conditions, respectively. The sample is prepared by passing it ten times.

The average particle diameter of the prepared sample was measured using the dynamic light scattering method (Beckman Coulter N5) about the thing left standing for 3 days and 1 month in the 30 degreeC incubator immediately after preparation.

In addition, the degree of change (increase) in the average particle diameter of the sample and the state change of the vesicle after one month with respect to the average particle diameter of the sample immediately after preparation were determined using the following four-step criteria.

<Four Steps Criteria>

(Judgement): (Change in average particle size and state after 1 month immediately after preparation)

◎ (very good): No change or 2 times or less of average particle diameter immediately after preparation

○ (good): greater than 2 times and less than 5 times

△ (slightly poor): greater than 5 times and less than 20 times

× (poor): greater than 20 times or incapable of quantification due to collapse of the vesicle

As is clear from the observation results of the transmission electron microscope and the polarizing microscope (FIGS. 1 and 2) and the results of the above table, the vesicle composition of the present invention 1 using the component (A) forms a good vesicle composition and has stability over time. It was also excellent in.

On the other hand, the vesicle composition of Comparative Product 1, which uses a long-chain quaternary alkylammonium salt type cationic surfactant instead of component (A), has a vesicle but is a vesicle after one month compared to the vesicle immediately after preparation. The average particle diameter of was greatly increased or the vesicle collapsed (broadcasting of the particle size distribution), resulting in poor stability over time.

Example 2 (Invention 2 to 4): Vacicle Composition

Dicocoylethylhydroxyethylmonium methosulfate (80%) propylene glycol solution used as component (A) in the preparation of the present invention 1 was dipalmitoylethylhydroxyethylmonium methosulfate (90%) isopropanol solution. A vesicle composition was prepared in the same manner except for changing (hereinafter, referred to as "the invention 2"). Moreover, the vesicle composition was similarly prepared except having changed the molar ratio 7/3 of (A) / (B) of this invention 1 to 1/4 (Hereinafter, this is called "this invention 3"). Furthermore, isostearic acid was added to this invention 3, and the vesicle composition was similarly prepared (hereinafter, this is called "this invention 4"). In the same manner as in Example 1, the state change of the vesicle was evaluated. The formulations and results are shown in Table 2 below.

(Manufacturing method of the present inventions 2-4)

A: The components 1-4 are melt | dissolved by heating at 100 degreeC.

B: Component 5 is heated to 90 ° C.

C: A is added to B and mixed and stirred with a homomixer.

D: C was cooled to room temperature to obtain a vesicle composition.

<Evaluation of penetration into the hair (observation of hair cross section)>

Example 3 (Invention 5 and Comparative Products 3 to 4)

Next, by the prescription shown in the following table | surface and the following manufacturing method, a fluorescent marker; A pyrene containing vesicle composition (sample) was prepared and the permeability into hair inside was evaluated by the following method.

(Manufacturing method)

A: The components 1-5 are melt | dissolved by heating at 100 degreeC.

B: Component 6 is heated to 90 ° C.

C: A is added to B and mixed and stirred with a homomixer.

D: C was cooled to room temperature to prepare a sample.

(Assessment Methods)

(1) The hair | bristle bundle (hair) is immersed for 12 hours in samples, such as a pyrene containing vesicle composition prepared by the said table | surface and the said manufacturing method.

(2) Remove the hair from (1) and embed the resin, and make a section of the hair cross section with a microtome.

(3) Observation of the cross section of the hair cross section of (2) with a fluorescence microscope (observation conditions of the fluorescence microscope: excitation filter: 330-385 nm, fluorescent filter: 420 nm, exposure time: 0.20 S). About the obtained vesicle composition, the permeability to the inside of hair of pyrene which is a fluorescent marker was considered, and the permeability to the inside of hair of a vesicle composition (cholesterol) was evaluated.

The result (photograph) of the observation with the fluorescence microscope of said (3) is shown in FIG.

3-1, FIG. 3-2, FIG. 3-3, and FIG. 3-4 of the photograph of FIG. It is sectional drawing of the hair immersed in the sample of article 4.

In the photograph of FIG. 3, the part which is bluish (part which looks white in a black-and-white drawing) shows that pyrene which is a fluorescent marker exists.

From the photograph of FIG. 3, FIG. 3-2 which immersed in the comparative product 2 which does not mix | blend pyrene shows almost nothing (the shape of a hair cross section is unknown), and immersed in the comparative product 3 which only added pyrene to hydrocarbon oil. Fig. 3-3 is a comparative product using a long-chain quaternary alkylammonium salt type cationic surfactant instead of component (A), only faintly blue (white in black and white drawing) to show the state of hair cross section. 3-4 immersed in 4 is slightly bluish (흼 in black and white drawing) than the immersion in Comparative 3, and it is understood that the state of the cross section of the hair is not so different.

On the other hand, in FIG. 3-1 immersed in the vesicle composition of the invention 5, the entire hair cross section is clearly bluish (white in the black and white drawings), and shines well to the center of the hair, compared to the immersion in the comparative test example. have.

That is, it turns out that the vesicle composition of this invention 5 prepared using the component (A) has very high permeability to hair inside.

Since the component (A) has a microscopic polarity due to the ester bonds contained in the lipophilic group, the vesicle film has excellent membrane fluidity (deformation of the vesicle film), and thus easily penetrates into the hair. For this reason, it is thought that high permeability was exhibited.

(Experimental conditions and results regarding component retention and retention)

In addition, the invention 5 prepared above was infiltrated into the hair to quantify the proportion of bound water in the hair. The result is shown in FIG. This effect relates to the effect of providing a moist feeling to the hair of the hair cosmetic (hair lotion). In addition, the near-infrared spectrophotometer "Spectrum400" (made by Perkin Elmer) was used for the measurement, and the hair | bristle bundle (about 5 g) which becomes the same hair was used as a test sample. Specifically, it is as follows.

This invention 5 was apply | coated to the hair | bristle bundle, it dried well, and the hair sample was obtained. As a comparative control, purified water was applied to the hair bundle (about 5 g) of the same human hair, and the well-dried reference hair sample was obtained. A near-infrared spectroscopic measurement, 5350 cm ^-1 ~ carried out in a range of 4950 cm ^-1, by applying a peak area of the obtained spectrum, the following equation 1 was determined the binding ratio of the hair.

[Formula 1]

Peak area 1 (5150 cm ^-1 to 4950 cm ^-1 ): Strong binding water (meaning that water is unlikely to evaporate from the hair)

Peak area 2 (5350 cm ^-1 to 5150 cm ^-1 ): Weak binding water (meaning that water is easily evaporated from the hair)

From the result shown in FIG. 4, compared with the reference hair sample which apply | coated purified water, it can be understood that the hair sample which apply | coated this invention 5 increased the ratio of the number of bonds in the hair significantly. This shows that the water retention and the maintenance ability of the hair were improved by the application of the invention 5, that is, it can be understood that the imparting of the moist feeling to the hair is due to this effect.

Example 4

(Evaluation over time of vesicle composition)

Becicle Sample 1 (i.e., DEQ / CL = 10/0 (molar ratio)), DEQ and Cholesterol (CL) obtained by dispersing 1 part by mass of dipalmitoylethylhydroxyethylmethanemethosulfate (DEQ) in 99 parts by mass of water Was premixed at a molar ratio of 7/3, and 1 part by mass thereof was dispersed in 99 parts by mass of water to obtain vesicle sample 2 (that is, DEQ / CL = 7/3 (molar ratio)) and distearyldimethylammonium chloride (DSAC) A vesicle sample 3 (that is, DSAC / CL = 10/0 (molar ratio)) obtained by dispersing 1 part by mass of 99 parts by mass of water, and preliminarily mixed DSAC and CL in a molar ratio of 7/3, and A vesicle sample 4 (ie, DSAC / CL = 7/3 (molar ratio)) obtained by dispersing 1 part by mass in 99 parts by mass of water was prepared. The reagents used for preparation of each sample are the same as the reagents used in Example 1, respectively.

In preparation of each sample, after dissolving each component in tetrahydrofuran (THF), the solvent (THF) is removed with the rotary evaporator, it heated at 80 degreeC, poured purified water, and probe type ultrasonic irradiation machine "VCX130PB" (SONIC & MATERIALS) 30 minutes of ultrasonic irradiation was used to prepare. Solid content concentration of each obtained sample was unified at 1 mass%. The obtained vesicle dispersion was treated with an extruder a plurality of times, and the average particle diameter was made uniform, and then the change in the average particle diameter over time was observed.

In addition, each sample was observed with the polarizing microscope, and in the initial stage, the maltide cross phase was confirmed, ie, the vesicle was formed.

The results are shown in FIGS. 5 and 6, respectively.

From the result shown in FIG. 5, in the vesicle composition containing dipalmitoylethylhydroxyethylmonium metosulfate (DEQ) which is an example of the component (A) of this invention, the sample 2 which added cholesterol did not add cholesterol. Compared with the sample 1 which did not, the diameter of a vesicle particle does not fluctuate and it is understood that it is excellent with time stability.

On the other hand, from the result shown in FIG. 6, in the vesicle composition containing the distearyl dimethylammonium chloride (DSAC) which has a long-chain alkyl group which does not contain an ester bond, the time-lapse stability of the sample 4 is remarkable by addition of cholesterol. I can understand that it was degraded.

In addition, differential scanning about the vesicle sample 1 (ie, DEQ / CL = 10/0 (molar ratio)) prepared above, and the vesicle sample 2 (ie, DEQ / CL = 7/3 (molar ratio)) Since the calorie value was measured, the result is shown in FIG. In addition, "DSC7020" (SII) was used for the measurement, and aluminum oxide powder and temperature rising conditions were made into 1 degree-C / min for the reference substance, and it measured in 30 to 110 degreeC.

From the DSC curve shown in FIG. 7, the endothermic peak (part enclosed by a circle in the drawing) accompanying the gel-liquid crystal transition of DEQ observed in the vesicle sample 1 at 35 ° C. to 45 ° C. was observed in vesicle sample 2. It is shown that DEQ and CL are compatible with each other at the molecular level, thereby forming a thermally stable gel-liquid crystal intermediate.

Example 5 (Invention 6-10 and Comparative Products 5-7): Hair cosmetics (hair lotion)

The cosmetics for hair are prepared according to the following formulation and the following preparation method shown in the following table, (A) stability over time, (B) adhesion to hair, (C) penetration into the hair), (D) moist feeling The provision was evaluated by the following method. The results are also shown in the following table.

(Manufacturing method)

A: The components 1-5 are melt | dissolved by heating at 100 degreeC.

B: Component 8 is heated to 90 ° C.

C: A is added to B and mixed and stirred with a homomixer.

D: C is cooled to room temperature.

E: 6 and 7 were added to D and the hair cosmetic (hair lotion) was obtained.

(Assessment Methods)

(A) Stability over time

Time-lapse stability was determined (evaluated) by the method similar to the said Example 1.

(Assessment Methods)

(B) adhesion to hair

(C) the feeling of penetration into the hair

(D) imparting a moist feeling

The test was carried out by 10 professional panelists, and (B) the adhesion to the hair, (C) the penetration into the hair, and (D) the imparting the moist feeling were each evaluated by the following five-level evaluation criteria. The average value was computed from the rating of the panel power supply for every sample, and it further determined by the following four steps criteria.

<Step 5 Evaluation Criteria>

(Rating): (evaluation)

5 points | pieces: Very good / I feel very strong

4 points | pieces: It feels good / strong.

3 points | pieces: Usually / It feels a little

2 points | pieces: A little bad

1 point: not bad / feeling

<Four Steps Criteria>

(Judgement): (Average score of rating)

(Double-circle): It exceeds 4.5 points

(Circle): More than 3.5 points and less than 4.5 points

(Triangle | delta): More than 1.5 points and less than 3.5 points

×: 1.5 points or less

As is clear from the results shown in the above table, all of the hair cosmetics of the inventions 6 to 10 have superior stability over time compared to the hair cosmetics of the comparative products 5 to 7, and when applied to the hair, they adhere to the hair quickly and the cosmetics adhere to the inside of the hair. I could feel the penetration penetrating into, and it was excellent in giving a moist feeling. Moreover, the invention 9, 10 which mix | blended the component (D) which tends to make it difficult to ensure stability with time, among others, has the adhesiveness with respect to hair, the permeation into the hair inside, the provision of a moist feeling, etc. Not only was it excellent, it showed sufficient stability over time, and especially this invention 9 which mix | blended ethyl alcohol as a component (D) adhered quickly to hair, and was excellent in permeability very much.

On the other hand, the comparative products 5 and 7 which use the general 2-long quaternary alkylammonium salt type | mold cationic surfactant also include the comparative product 6 which mix | blended stearyl alcohol instead of the component ( B ), and are all bad with time stability, and hair It was also less penetrating inside.

Moreover, the comparative product 4 which used the higher alcohol instead of the component (B) was bad with time stability and the penetration permeability into the hair inside even if the component (A) was used, and the provision of a moist feeling was inferior.

Example 6: Blessicle Composition

(ingredient) (%)

Dipalmitoylhydroxyethylmonium metosulfate

90% isopropanol solution * 4 3

2. Phytosterol * 5 0.36

3. 1,2-pentanediol 5

4. Residual Purified Water

* 4: DEHYQUART AU56 / G (molecular weight manufactured by Cognis): 751

* 5: phytosterol (average molecular weight manufactured by Eisaisa: 409.4)

(Manufacturing method)

A: The components 1-3 are melt | dissolved by heating at 100 degreeC.

B: Component 4 is heated to 90 ° C.

C: A is added to B and emulsified by a homomixer.

D: C was cooled to room temperature to obtain a vesicle composition.

When the vesicle composition of Example 6 was evaluated by the same method as Example 1, a favorable vesicle was formed and the maltide cross phase was observed. Moreover, there was little change of the average particle diameter with time, and it was excellent in stability.

In the vesicle composition of Example 6, the molar ratio (A) / (B) of component (A) and component (B) was 4.

Example 7: Hair Cosmetics (Hair Milk)

(ingredient) (%)

1. Dicoylethylhydroxyethylmonium methosulfate

80% propylene glycol solution * 1 3

2. Cholesterol * 3 0.75

3. Olive Oil 0.75

4. Propylene Glycol 5

5. Refining water level

(Manufacturing method)

A: The components 1,2 and 3 are melt | dissolved by heating at 100 degreeC.

B: Component 5 is heated to 90 ° C.

C: A is added to B and mixed and stirred with a homomixer.

D: C is cooled to room temperature to obtain a vesicle composition.

E: Component 4 is added to D and cooled to room temperature.

F: E was put in the container and hair cosmetic (hair milk) was obtained.

The hair cosmetic (hair milk) of Example 7 was evaluated in the same manner as in Example 1 and Example 3, and it was found that a maltide cross phase was observed and a good vesicle was formed. Moreover, it was excellent in all the provision of stability with time, adhesiveness to hair, a permeability, and a moist feeling.

In addition, in the cosmetics for hair (hair milk) of Example 7, molar ratio (A) / (B) of component (A) and component (B) was 1.8.

Example 8: Hair Cosmetic (Hair Lotion)

(ingredient) (%)

1. Dicoylethylhydroxyethylmonium methosulfate

80% propylene glycol solution * 1 3

2. Cholesterol * 3 0.36

3. Purified Water 30

4. Dimethylpolysiloxane (100 CS) 0.5

5. Isostearic Acid 0.54

6. Propylene Glycol 5

7. Ethyl Alcohol 5

8. Refining water level

9. Spices 0.1

(Manufacturing method)

A: The components 1,2 and 5 were melt | dissolved by heating at 100 degreeC.

B: Component 3 is heated to 90 ° C.

C: A is added to B and mixed and stirred with a homomixer.

D: C is cooled to room temperature to obtain a vesicle composition.

E: The components 4 and 6 are added to D, and it mixes uniformly.

F: The components 7-9 are added to E, and it mixes uniformly.

G: F was filled in the container and the hair cosmetic (hair lotion) was obtained.

When the hair cosmetics (hair lotion) of Example 8 were evaluated by the same method as Example 1, Example 3, the good maltize cross phase was observed and it turned out that the favorable vesicle is formed. Moreover, it was excellent in all the provision of stability with time, adhesiveness to hair, a permeability, and a moist feeling.

In addition, in the hair cosmetic of Example 8, molar ratio (A) / (B) of component (A) and component (B) was 3.8.

Example 9: Hair Cosmetic (Hair Essence)

(ingredient) (%)

1. The vesicle composition 90 of the present invention 1

2. Purified Water 4.6

3. Glycerin 5

4. Sorbitol 0.1

5. Glycine 0.1

6. Seaweed Emulsion 0.1

7. Spices 0.1

(Manufacturing method)

A: The components 1 and 2 are mixed uniformly at room temperature.

B: Components A and 6, and 7 are added and mixed uniformly.

C: B was filled in the container and hair cosmetic (hair essence) was obtained.

The hair cosmetics (hair essences) of Example 9 were evaluated in the same manner as in Example 3, and were excellent in providing stability over time, adhesion to hair, penetration, and moist feeling.

Example 10 Hair Cosmetics (Hair Mist)

(ingredient) (%)

1. The vesicle composition 1 of Example 6

2. Hydrolyzed Collagen Solution 0.3

3. Refining water level

(Manufacturing method)

A: The components 1-3 are mixed uniformly at room temperature.

B: A was filled in the mist container and the cosmetics for hair were obtained.

The hair cosmetics (hair mist) of Example 10 were evaluated in the same manner as in Example 3, and were excellent in providing stability over time, adhesiveness to hair, penetration, and moist feeling.

Example 11 Moisturizing Cosmetic for Body

(ingredient) (%)

1.Vacicle Composition 0.5 of Invention 4

2.L-Theanine 0.1

3. Sodium hyaluronate (1% aqueous solution) 5.0

4. Residual Purified Water

(Manufacturing method)

A: The components 1-4 are mixed uniformly at room temperature.

B: A was filled in the container and the moisturizing cosmetic for body was obtained.

The body moisturizing cosmetic of Example 11 was evaluated by the same method as Example 3, and it was excellent in all the provision of stability with time, adhesiveness to skin, a permeability, and a moist feeling.

Claims (6)

Next component (A)-(C),
(A) Formula 1
[Chemical Formula]

(In the formula, R ¹ CO-, R ² CO-, ah the same or different, aliphatic having a carbon number of 8 to 22 saturated or unsaturated group; R ³ is -CH _3, or -CH ₂ OH, or -C ₂ H ₄ OH; m, n are the same or different, and 2 or 3; X represents halogen, methosulfate, ethosulfate or metophosphate
(B) sterols
(C) water
A vesicle composition comprising a. The method of claim 1,
Molar ratio (A) / (B) of component (A) and component (B) exists in the range of 100/1-1/4. The vesicle composition characterized by the above-mentioned. The method according to claim 1 or 2,
A vesicle composition, characterized in that component (B) is cholesterol and / or phytosterol. The cosmetic composition characterized by mix | blending the vesicle composition in any one of Claims 1-3. The method of claim 4, wherein
Cosmetics characterized in that it is for hair. The method according to claim 4 or 5,
Furthermore, cosmetics characterized by mix | blending monohydric lower alcohol as a component (D).

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