JP5774986B2 - Vesicle composition and cosmetics containing the same - Google Patents

Description

  The present invention relates to a vesicle composition having a specific cationic surfactant, sterols, and water as constituents and excellent in stability over time, and a cosmetic containing the composition, and in particular, the composition. The present invention relates to a hair cosmetic composition that, when applied to hair, quickly adjusts to the hair, has excellent penetration into the hair, and provides a moist feeling.

Conventionally, sterols such as cholesterol and phytosterol have been studied for incorporation into hair cosmetics as effective components for hair. In particular, cholesterol is originally present in hair as a component related to the moisture retention function of hair, but its content is said to decrease around the age of 10 (see Non-Patent Document 1), and it is moist and dry. It is one of the important ingredients for keeping beautiful hair.
However, sterol derivatives such as cholesterol are generally known as poorly soluble substances that are hardly soluble in water and oil (see Patent Document 1), and are particularly stable in lotion-based preparations using water as a medium. It is very difficult to blend in. For this reason, various studies have been conducted on techniques for stably blending these poorly soluble sterol derivatives into cosmetics in aqueous media.
For example, by mixing a quaternary alkyl ammonium salt type cationic surfactant with an amphiphile, a sterol derivative, and water at a specific blending ratio, a bilayer membrane vesicle of lamellar liquid crystal containing an aqueous phase, That is, it is known that vesicles are formed (see Patent Document 2).
As another study, by adding a cationic polymer (see Patent Document 3) and silicone (see Patent Document 4) to a quaternary alkyl ammonium salt type cationic surfactant, a sterol derivative, and a ceramide, It is also known that vesicles are formed.
Furthermore, there is an example in which sterols such as cholesterol are blended using dicocoylethylhydroxyethylmonium methosulfate having an ester structure in a hydrophobic group as a cationic surfactant different from those in Patent Documents 2 to 4 above ( (See Patent Document 5).

Journal of Cosmetic Science Society (Vol.13 No.3 1989, p.134-p.139) JP 2006-176410 A JP 2001-97811 A JP 2006-199634 A JP 2006-199635 A JP 2006-182743 A

  However, all of the techniques of Patent Documents 2 to 4 use a quaternary alkyl ammonium salt type cationic surfactant, and if a quaternary alkyl ammonium salt type cationic surfactant is used, sterols In some cases, vesicles were not sufficiently formed, or the vesicles were broken and precipitated over time, and crystallized and precipitated. Furthermore, even when such vesicles are blended into hair cosmetics and applied to hair, there is a problem that it feels familiar with the hair and penetrates into the hair; it is difficult to obtain a sense of penetration and it is difficult to obtain a moist feeling.

  Further, according to Patent Document 5, a poorly soluble component such as cholesterol may not be stably blended in a vesicle, so that cholesterol and the like are precipitated over time, and it is difficult to bring about an effective effect on hair. It was.

  Accordingly, an object of the present invention is to provide a vesicle composition that can stably blend sterols such as cholesterol, which is an effective ingredient for hair, into an aqueous medium, and that is excellent in stability over time, and a cosmetic comprising the same. . In particular, it is a cosmetic for hair formulated with the composition, and when applied to hair, it is adapted to hair quickly, has excellent penetration into hair, and has a moisturizing effect. It is an object to provide cosmetics.

  As a result of intensive studies to solve the above problems, the present inventors have obtained a vesicle composition having excellent temporal stability by combining a cationic surfactant having a specific chemical structure, sterols, and water. The composition can be stably blended in water-based cosmetics, and when blended in hair cosmetics and applied to hair, the cosmetics quickly adapt to the hair surface without staying on the hair surface. It has been found that a cosmetic for hair that is excellent in penetrability, can feel the permeation of active ingredients, and has a moist feeling imparting effect, and has completed the present invention.

That is, the present invention includes the following components (A) to (C),
(A) The following general formula (1)
(In the formula, R ¹ CO— and R ² CO— are the same or different and are a saturated or unsaturated aliphatic acyl group having 8 to 22 carbon atoms, R ³ is —CH ₃ or —CH ₂ OH, Or -C ₂ H ₄ OH, m, n are the same or different, 2 or 3, X represents a halogen, methosulphate, ethosulphate or methophosphate) (B) Sterol Class (C) The present invention provides a vesicle composition characterized by containing water.

  Moreover, this invention provides the vesicle composition characterized by the molar ratio (A) / (B) of a component (A) and a component (B) being in the range of 100/1-1/4. Is.

  The present invention also provides a vesicle composition wherein component (B) is cholesterol and / or phytosterol.

  Moreover, this invention provides the cosmetics characterized by mix | blending this vesicle composition. A preferred embodiment of the cosmetic of the present invention is a hair cosmetic.

  In addition, the present invention is characterized in that a monovalent lower alcohol is further added as a component (D) to the vesicle composition or the cosmetic.

  The vesicle composition of the present invention has excellent temporal stability and can be stably blended into cosmetics. In particular, hair cosmetics formulated with the composition, when applied to the hair, quickly adjust to the hair, have excellent penetration into the hair, can feel the penetration, and provide a moist feeling. Are better.

It is the photograph which observed the vesicle composition of this invention product 1 with the transmission electron microscope. It is the photograph which observed the presence of the Maltese cross image used as the parameter | index of the formation of the vesicle in the vesicle composition of this invention product 1 under the polarization | polarized-light Nicols. It is the photograph of the hair cross section which evaluated the permeability to the inside of hair. Fig. 3-1: Photo of hair cross section immersed in sample 5 of the present invention. Fig. 3-2: Photo of hair cross section immersed in sample of comparative product 2 (no fluorescent marker added). FIG. 3-3: Photograph of hair cross section immersed in sample of comparative product 3. Fig. 3-4: Photograph of hair cross section immersed in sample of comparative product 4. It is a graph which shows the result of having evaluated the combined water ratio in the hair of the sample of this invention product 5. FIG. It is the result of evaluating the temporal stability of a vesicle composition containing dipalmitoylethylhydroxyethylmonium methosulfate (DEQ). It is the result of having evaluated the temporal stability of the vesicle composition containing distearyl dimethyl ammonium chloride (DSAC). It is a differential scanning calorimetry (DSC) measurement result of the vesicle composition containing dipalmitoylethylhydroxyethylmonium methosulphate (DEQ).

The present invention will be described in detail.
The present invention relates to a vesicle composition containing predetermined components (A) to (C).
In the present specification, the “vesicle composition” means a closed spherical endoplasmic reticulum in water, in which a Martellose cross image is observed with a polarizing microscope, and another observation method is transmission. This means that multilamellar vesicles having a multi-layer structure are observed with a scanning electron microscope.

The component (A) cationic surfactant used in the present invention has the following general formula (1):
(In the formula, R ¹ CO— and R ² CO— are the same or different and are a saturated or unsaturated aliphatic acyl group having 8 to 22 carbon atoms, R ³ is —CH ₃ or —CH ₂ OH, Or -C ₂ H ₄ OH, m, n are the same or different, 2 or 3, and X represents halogen, methosulphate, ethosulphate or methophosphate). The activator is the main component of the bimolecular film that forms vesicles in the present invention. Has an ester bond in the hydrophobic chain (also referred to as ester quart), and is generally superior in hair conditioning effects as compared to long-chain alkyl type surfactants having the same carbon number. Excellent degradability.
In the present invention, by using the component (A), microscopic membrane fluidity (hereinafter referred to as “deformability of the vesicle membrane”) is excellent in stability over time and evaluates the deformability of the bilayer membrane in the vesicle structure. A vesicle composition that is also excellent in abbreviations), and when the component (B) described later is encapsulated in the vesicle formed by the component (A), the active hair component such as the component (B) It can be kept stable until use. And when applied to the hair, it efficiently penetrates into the hair, and the active ingredients such as the component (B) are stably delivered into the hair, thereby giving a moist feeling. .
Specific examples of component (A) include dicocoylethylhydroxyethylmonium methosulfate, distearoylethylhydroxyethylmonium methosulfate, dipalmitoylethylhydroxyethylmonium methosulfate, and the like. Commercially available products such as DEHYQUAT L80, DEHYQUAT F75, DEHYQUAT AU56 / G, DEHYQUART C4046 (all manufactured by Cognis) can also be used. Of these, especially dicocoylethylhydroxyethylmonium methosulphate has the stability over time of the resulting vesicle composition and the permeability (penetration feeling) when a cosmetic for hair containing the vesicle composition is applied to the hair. It is preferable from the point.

The blending amount of the component (A) of the present invention in the vesicle composition is not particularly limited, but is preferably 0.001 to 10% by mass (hereinafter simply referred to as “%”), more preferably 0.01 to 5%. preferable.
If the blending amount is within this range, a vesicle composition excellent in stability over time and deformability of the vesicle film can be obtained.When blended in cosmetics, it is very stable until use, for example, When applied to the hair, an active hair component such as component (B) penetrates efficiently into the hair, and a moist feeling is obtained.

  The sterols of component (B) used in the present invention contribute to the formation and stabilization of vesicles, and also to impart a moist feeling to hair when the obtained vesicle composition is blended in hair cosmetics. Formulated as a contributor.

  For example, when a sterol is added to a vesicle system containing distearyldimethylammonium chloride (manufactured by Lion Akzo) having a long-chain alkyl group that does not contain an ester group as a conventionally used cationic surfactant, The system may cause aggregation. However, when sterols are added to a vesicle system containing a cationic surfactant represented by the above formula (1) containing a long alkyl chain containing an ester group, unexpectedly, the vesicle system is remarkably stabilized. Has been found by the present inventors.

  The component (B) sterols may be any substance having a sterol skeleton or a derivative thereof. For example, cholesterol, phytosterol (β-sitosterol, campesterol, stigmasterol, brassicasterol, etc.), lanosterol, polyoxyethylene Cholesteryl ether, macadamian nut oil fatty acid cholesteryl, macadamian nut oil fatty acid phytosteryl, palm oil fatty acid cholesteryl, phytosteryl oleate, N-lauroyl-L-glutamate di (cholesteryl behenyl octyldodecyl), N-lauroyl-L-glutamic acid Di (octyldodecyl phytosteryl behenyl), N-lauroyl-L-glutamate di (phytosteryl octyldodecyl), phytosteryl oleate 1 or 2 or more of these can be used, and among them, it has a sterol skeleton represented by the following general formula (2), and R is an aliphatic group (for example, linear or branched) Sterols which are a chain alkyl group and a linear or branched alkenyl group) are preferable, and cholesterol and phytosterol are particularly preferable.

  Commercially available products include Nissui Marine Cholesterol (manufactured by Nippon Suisan), Marine Cholesterol (manufactured by Kyowa Technos), Phytosterol (manufactured by Eisai Food Chemical), Rice Sterol (manufactured by Tsukino Rice Fine Chemicals), EMALEX CS-10 ( Nippon Emulsion Co., Ltd.), El Dew PS-203, El Deu PS-304, El Deu PS-306 (above, manufactured by Ajinomoto Co., Inc.) and the like can be used.

  Although the compounding quantity of the component (B) of this invention is not specifically limited, 0.001 to 5% is preferable in a vesicle composition, and 0.01 to 3% is more preferable. When used in this range, the vesicle composition is well formed, has excellent stability over time, and the component (B) effectively penetrates into the hair, so that a sufficiently moist feeling can be felt.

  Moreover, as for the compounding ratio of the component (A) and the component (B) of the present invention, the molar ratio (A) / (B) of the component (A) to the component (B) is preferably 100/1 to 1/4, More preferably, it is in the range of 9/1 to 3/7. When the molar ratio of (A) / (B) is within this range, the vesicle composition is excellent in microscopic membrane fluidity (deformability of vesicle membrane) and excellent in aging stability, The effective component (B) can efficiently penetrate into the hair, and the effect of the component (B) can be exhibited better.

  The component (C) water used in the present invention is used as a dispersion medium for vesicles, and is an essential component as a medium for vesicle compositions and cosmetics containing them. The blending amount is appropriately determined depending on the amount of other components, that is, the components (A) and (B), or the components (A) and (B), the component (D) described later, and components to be blended arbitrarily. Generally, it can be used in the range of 5 to 99%, more preferably 20 to 90%, and still more preferably 60 to 90%.

  In addition to the above components (A) to (C), the vesicle composition of the present invention contains a higher fatty acid that is liquid at 25 ° C. for the purpose of further improving the temporal stability of the component (B) against crystal precipitation. can do. Any higher fatty acid that is liquid at 25 ° C. may be used, and examples thereof include saturated branched fatty acids such as isomyristic acid, isopalmitic acid and isostearic acid, and unsaturated fatty acids such as oleic acid and linoleic acid. . Vegetable oils containing unsaturated fatty acids include avocado oil, almond oil, refined jojoba oil, grape seed oil, sesame oil, wheat germ oil, rice bran oil, soybean oil, corn germ oil, rapeseed oil, macadamia nut oil, meadow home oil, Peanut oil, rosehip oil, or the like may be used. As content of the liquid higher fatty acid in 25 degreeC, 0.5-1.5 times amount is mentioned by a mass ratio with respect to a component (B) as a preferable thing.

The method for producing the vesicle composition of the present invention is not particularly limited. For example, components (A) and (B) heated to 100 ° C. or higher are dispersed in component (C) heated to 90 ° C. or higher. Then, it is obtained by gradually cooling to room temperature while continuing stirring. Moreover, you may add the component which can be mix | blended arbitrarily as mentioned later in anticipation of the usability, the further effect on hair, etc. according to the property etc. suitably at the time of vesicle preparation.
The average particle size of the obtained vesicle composition is about 100 nm to 10 μm. Preferably, the average particle size is set to 50 to 500 nm using an apparatus such as an extruder, which will be described later, so that the vesicle disintegrates even with time. In other words, a product excellent in stability with little change (increase) in the average particle size can be obtained.

  The vesicle composition of the present invention prepared by the above method can be blended in various cosmetics such as hair cosmetics. In particular, a hair cosmetic blended with the vesicle composition of the present invention is preferable because it has excellent penetrability of the active ingredient into the hair.

The present invention also relates to a cosmetic containing the vesicle composition of the present invention. A lower monohydric alcohol can be blended as the component (D) in the cosmetic blended with the vesicle composition of the present invention.
The lower monohydric alcohol of component (D) is generally considered to be an important component in hair cosmetics in order to provide a quick drying time and a refreshing feeling during application, and contributes to good familiarity with hair. In a vesicle composition blending system, blending a lower monohydric alcohol is known to make it difficult to ensure stability over time.
However, in the present invention, by preparing a vesicle composition using the above component (A), even when the lower monohydric alcohol of component (D) is blended, a product having good temporal stability is obtained, When hair cosmetics formulated with this vesicle composition are applied to hair, they are well-familiar, have excellent penetration into the hair, can feel the penetration of active ingredients, and have a high moisturizing effect. Is obtained.
The lower monohydric alcohol of component (D) can be used without particular limitation as long as it is generally used in cosmetics, and examples thereof include ethyl alcohol, propyl alcohol, isopropyl alcohol, etc. In the present invention, ethyl alcohol Is preferred.

  The blending amount of the component (D) of the present invention is not particularly limited, and is appropriately determined according to properties desired as the target quality of the cosmetic to be prepared, for example, familiarity, penetration into hair, and the like. In general, the total amount is preferably 0.1 to 30%, more preferably 1 to 30%, further preferably 1 to 25%, and still more preferably 5 to 20%.

Although it does not specifically limit as a manufacturing method of the cosmetics of this invention, For example, as above-mentioned, after disperse | distributing component (A) and (B) to a component (C), it is made to cool to room temperature and is a vesicle composition. Can be produced by a method comprising preparing the component (B) and blending the component (D), an optional component described later, and the like with the vesicle composition. Arbitrary ingredients to be blended are blended with the expectation of a feeling of use and further effects on hair.
By blending the vesicle composition of the present invention into a cosmetic for hair, compared to a hair cosmetic formulated with an active ingredient such as component (B) without forming a vesicle, it has excellent temporal stability, In addition, it is possible to obtain a good product having excellent moisturizing effect and excellent permeation into the hair at the time of use and a sense of penetration.
In particular, in a cosmetic containing component (D), component (D) is originally a component that tends to make it difficult to ensure stability over time, but the vesicle composition of the present invention is used. By blending, it has good temporal stability, and, for example, in the form of hair cosmetics, it quickly adapts to the hair, has excellent penetration and penetration into the hair, and gives a moist feeling It can be excellent.

The blending amount of the vesicle composition in the cosmetic of the present invention is not particularly limited, and is preferably 0.5% or more and more preferably 10% or more in the total amount of the cosmetic. In addition, the vesicle composition of the present invention can be used as it is as a 100% cosmetic.
In addition, although there is no restriction | limiting in particular about the dosage form of the cosmetics of this invention, From a viewpoint of maintaining a vesicle stably, it is preferable to prepare as cosmetics of the dosage form whose external phase is a water system. The external phase may contain various agents (for example, ethyl alcohol, polyhydric alcohol, salts, surfactants, etc.) that can be dissolved and / or dispersed in water in addition to water.

  In addition to the components (A) to (C) and the component (D), the vesicle composition of the present invention and the cosmetic composition containing the same may be used as long as the effects of the present invention are not impaired. Surfactant, alcohol, metal soap, gelling agent, powder, water-soluble polymer, film forming agent, resin, moisturizer, antibacterial agent, fragrance, deodorant, salt, pH adjuster, refreshing agent, ultraviolet ray Absorbents, plant extracts, amino acids, saccharides, vitamins and other beauty ingredients for hair care can be blended.

  Oils include liquid, pasty and solid hydrocarbons, waxes, esters, and fatty acids at room temperature (even if the fatty acid is liquid at 25 ° C. and non-liquid higher fatty acid at 25 ° C. And oily components such as fats and oils can be used. Specifically, for example, hydrocarbons, fats and oils, waxes, hardened oils, ester oils, fatty acids, silicone oils, fluorine-based oils, lanolin derivatives and the like can be used, and more specifically, For example, waxes such as ozokerite, ceresin, paraffin, paraffin wax, microcrystalline wax, cetyl myristate, cetyl palmitate, petrolatum, liquid paraffin, pristane, polyisobutylene, squalane, squalene, liquid paraffin hydrocarbons, Waxes such as beeswax, carnauba wax, candelilla wax, whale wax, solid oils such as cetyl alcohol, stearyl alcohol, cetostearyl alcohol, behenyl alcohol, shea fat, beef tallow, beef leg fat, beef bone fat, cured beef tallow, cured oil, Turtle oil, pork fat, horse fat, mink oil, liver oil, Animal oil such as yellow oil, palm oil, olive oil, rice germ oil, rice bran oil, castor oil, macadamia nut oil, olive oil, almond oil, avocado oil, camellia oil, rosehip oil, safflower oil, sunflower oil, etc. Liquid oils such as vegetable oils and jojoba oil, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl oleate, cetyl caprate, hexyl laurate, decyl oleate, oleyl oleate, isostearyl laurate, isomyristate Stearyl, isocetyl myristate, octyldodecyl myristate, 2-ethylhexyl palmitate, isocetyl palmitate, isocetyl palmitate, 2-ethylhexyl stearate, isocetyl stearate, isodecyl oleate, oleic acid Cutyldecyl, 2-ethylhexanoate, cetyl 2-ethylhexanoate, hexyl isostearate, octyldodecyl neopentanoate, isostearyl octoate, 2-ethylhexyl isoperargonate, hexyldecyl dimethyloctanoate, octyldodecyl dimethyloctanoate, isopalmitate 2 -Ethylhexyl, isocetyl isostearate, isostearyl isostearate, isononyl isononanoate, ethylene glycol dioctanoate, propylene glycol dicaprate, neopentyl glycol dioctanoate, glyceryl tricaprate, glyceryl tri-2-ethylhexanoate, glyceryl triisostearate, tri-2-ethylhexane Trimethylolpropane acid, trimethylol triisostearate Ester oil such as rupropane, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, oleic acid, linoleic acid, arachidonic acid, docosahexaenoic acid (DHA), 12-hydroxystearic acid, isostearic acid, 2- Fatty acids such as ethylhexanoic acid, silicone oils such as dimethylpolysiloxane and methylphenylpolysiloxane, fluorine oils such as perfluorodecane, lanolin, liquid lanolin, reduced lanolin, lanolin alcohol, hard lanolin, lanolin acetate, lanolin fatty acid isopropyl Lanolin derivatives and the like.

The surfactant may be any of anionic, cationic, amphoteric, and nonionic, and examples of the anionic surfactant include fatty acid soaps such as sodium stearate and triethanolamine palmitate, alkyl ether carboxylic acids and the like. Salt, carboxylate such as condensation of amino acid and fatty acid, alkyl sulfonate, alkene sulfonate, sulfonate of fatty acid ester, sulfonate of fatty acid amide, sulfonate of alkyl sulfonate and its formalin condensate, Alkyl sulfate ester, secondary higher alcohol sulfate ester, alkyl and allyl ether sulfate ester, fatty acid ester sulfate ester salt, fatty acid alkylolamide sulfate ester salt, funnel sulfate sulfate salt, alkyl phosphate , Ether phosphate, al Le allyl ether phosphates, amide phosphates, etc. N- acylamino acid-based active agents.
As cationic surfactants, other than component (A), amine salts such as alkylamine salts, polyamines and aminoalcohol fatty acid derivatives, alkyl quaternary ammonium salts, aromatic quaternary ammonium salts, pyridinium salts, imidazolium salts, etc. Is mentioned.
Examples of amphoteric surfactants include betaines, aminocarboxylates, imidazoline derivatives, and the like.
Nonionic surfactants include sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, polyethylene glycol fatty acid ester, sucrose fatty acid ester, polyoxyethylene alkyl ether, polyoxypropylene alkyl ether, poly Oxyethylene alkyl phenyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene propylene glycol fatty acid ester, polyoxyethylene castor oil, polyoxyethylene Hydrogenated castor oil, polyoxyethylene phytostanol ether, polyoxyethylene N-phytosterol ether, polyoxyethylene cholestanol ether, polyoxyethylene cholesteryl ether, polyoxyalkylene-modified organopolysiloxane, polyoxyalkylene-alkyl co-modified organopolysiloxane, lauric acid diethanolamide, coconut oil fatty acid diethanolamide, coconut oil fatty acid Examples include monoethanolamide, polyoxyethylene coconut oil fatty acid monoethanolamide, lauric acid monoisopropanolamide, coconut oil fatty acid monoisopropanolamide, sugar ether, and sugar amide.

  The alcohol may be anything other than component (D), such as glycerin, diglycerin, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, 1,2 -Polyhydric alcohols such as pentanediol and polyethylene glycol.

  As the metal soap, 12-hydroxy aluminum stearate, zinc stearate, aluminum stearate, calcium stearate, magnesium stearate, zinc myristate, magnesium myristate, zinc cetyl phosphate, calcium cetyl phosphate, zinc sodium cetyl phosphate, zinc laurate And zinc undecylenate.

  Gelling agents include amino acid derivatives such as N-lauroyl-L-glutamic acid, α, γ-di-n-butylamine, dextrins such as dextrin palmitate, dextrin stearate, dextrin 2-ethylhexanoate palmitate, etc. Fatty acid esters, sucrose fatty acid esters such as sucrose palmitate ester, sucrose stearate ester, benzylidene derivatives of sorbitol such as monobenzylidene sorbitol, dibenzylidene sorbitol, dimethylbenzyl dodecyl ammonium montmorillonite clay, dimethyl dioctadecyl ammonium montmorillonite clay, etc. Examples include organically modified clay minerals.

  If the powder is used in ordinary cosmetics, its shape (spherical, needle-like, plate-like, etc.), particle size (smoke-like, fine particles, pigment grade, etc.), particle structure (porous) Any inorganic powder can be used, for example, magnesium oxide, barium sulfate, calcium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, talc, synthetic mica. , Mica, kaolin, sericite, muscovite, synthetic mica, phlogopite, saucite, biotite, lithia mica, silicic acid, anhydrous silicic acid, aluminum silicate, magnesium silicate, aluminum magnesium silicate, calcium silicate, Barium silicate, strontium silicate, metal tungstate, hydroxyapatite, vermiculite, hydrite, montmorillonite, z Light, ceramic powder, dicalcium phosphate, alumina, aluminum hydroxide, boron nitride, boron nitride, etc .; organic powders include polyamide powder, polyester powder, polyethylene powder, polypropylene powder, polystyrene powder, polyurethane, benzoguanamine powder, polymethyl Benzoguanamine powder, tetrafluoroethylene powder, polymethyl methacrylate powder, cellulose, silk powder, nylon powder, 12 nylon, 6 nylon, styrene / acrylic acid copolymer, divinylbenzene / styrene copolymer, vinyl resin, urea resin, phenol Resin, fluororesin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, microcrystalline fiber powder, Lauro Luridine, etc .; as colored pigments, inorganic red pigments such as iron oxide, iron hydroxide and iron titanate, inorganic brown pigments such as γ-iron oxide, yellow inorganic oxides such as yellow iron oxide and loess, black iron oxide, Inorganic black pigments such as carbon black, inorganic purple pigments such as manganese violet and cobalt violet, inorganic green pigments such as chromium hydroxide, chromium oxide, cobalt oxide and cobalt titanate, inorganic blue pigments such as bitumen and ultramarine, tar Dye raked, natural dye raked, composite powder made by combining these powders, etc .; pearl pigments include titanium oxide-coated mica, titanium oxide-coated mica, bismuth oxychloride, titanium oxide Coated bismuth oxychloride, titanium oxide coated talc, fish scale foil, titanium oxide coated colored mica, etc .; -Powder, stainless steel powder, etc. As tar pigments, Red No. 3, Red No. 104, Red No. 106, Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 227 , Red 228, Red 230, Red 401, Red 505, Yellow 4, Yellow 5, Yellow 202, Yellow 203, Yellow 204, Yellow 401, Blue 1, Blue 2, Blue No. 201, Blue No. 404, Green No. 3, Green No. 201, Green No. 204, Green No. 205, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 206, Orange No. 207, etc .; A powder selected from acids, laccaic acid, calsamine, bradylin, crocin, etc., and these powders are compounded or surface treated with oils, silicones, or fluorine compounds It may be carried out powder.

  Examples of water-soluble polymers include gum-based polymers such as gum arabic, tragacanth, galactan, carob gum, guar gum, caraya gum, carrageenan, pectin, agar, quince seed, algae colloid, tant gum, locust bean gum, galactomannan, xanthan gum, dextran , Microbial polymers such as succinoglucan and pullulan, starch polymers such as starch, carboxymethyl starch and methylhydroxypropyl starch, methylcellulose, ethylcellulose, methylhydroxypropylcellulose, carboxymethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, nitro Cellulose, sodium cellulose sulfate, sodium carboxymethyl cellulose, crystalline cellulose, cellulose powder Cellulose polymers, sodium alginate, alginic acid polymers such as propylene glycol alginate, vinyl polymers such as polyvinyl methyl ether, carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, polyoxyethylene polymers, polyoxyethylene poly Examples include oxypropylene copolymer-based polymers, acrylic polymers such as sodium polyacrylate, polyethyl acrylate, and polyacrylamide, and inorganic water-soluble polymers such as polyethyleneimine, cationic polymers, bentonite, laponite, and hectorite. Also included are film forming agents such as polyvinyl alcohol and polyvinyl pyrrolidone.

  Examples of the moisturizing agent include chondroitin sulfate, hyaluronic acid, mucin, dermatan sulfate, mucopolysaccharides such as heparin and keratan sulfate, proteins such as soybean protein and wheat protein, or derivatives thereof, collagen, elastin, keratin and the like. It is done.

  Antibacterial agents include benzoic acid, sodium benzoate, salicylic acid, coalic acid, sorbic acid, potassium sorbate, paraoxybenzoic acid ester, parachlorometacresol, hexachlorophene, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide, photosensitive Element, bis (2-pyridylthio-1-oxide) zinc, phenoxyethanol, isopropylmethylphenol and the like.

  Examples of the UV absorber include 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, and 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid sodium as benzophenone series. 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone-5-sulfonic acid sodium salt, 2,4-dihydroxybenzophenone, 2,2 ′, 4 , 4′-tetrahydroxybenzophenone, etc., and examples of the PABA system include paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, 2-dimethylhexyl paradimethylaminobenzoate, paradihydro Examples include cipropyl benzoate and the like. Cinnamic acid type includes p-methoxycinnamic acid-2-ethylhexyl, 4-methoxycinnamic acid-2-ethoxyethyl and the like. Salicylic acid type includes salicylic acid- Examples thereof include 2-ethylhexyl, phenyl salicylate, homomenthyl salicylate, and the like, and other examples include 2- (2-hydroxy-5-methylphenyl) benzotriazole, 4-tert-butyl-4′-methoxydibenzoylmethane, oxybenzone, and the like. .

  As a pH adjuster, lactic acid, citric acid, glycolic acid, succinic acid, tartaric acid, malic acid, phosphoric acid and their salts, potassium carbonate, sodium hydrogen carbonate, ammonium hydrogen carbonate, etc., as a refreshing agent, L-menthol, For example, camphor.

Plant extracts include birch, clams, salvia, hops, rosemary, roses, oranges, asparagus, assembly, red goose, honeysuckle, perilla, capsicum, salamander, nettle, tea, carrot, savanna, Ibukitorano, grape, Examples include plants such as seaweed, soybean, elderberry, and herbal extracts.

  Examples of amino acids include glycine, proline, isoleucine, histidine, alanine, arginine, lysine, serine, cysteine, acetylcysteine, and the like.

  Examples of the saccharide include glucose, fructose, galactose, mannitol, sorbitol and the like.

  Vitamins such as vitamin A and derivatives thereof, vitamin B and derivatives thereof, vitamin C and derivatives thereof, vitamin E and derivatives thereof, linolenic acid and derivatives thereof, and vitamins such as phytonadione, menaquinone, menadione, menadiol Ks; vitamin Ps such as eriocitrin and hesperidin; and biotin, carcinine, ferulic acid and the like.

  Cosmetics such as hair cosmetics formulated with the vesicle composition of the present invention can be prepared in liquid form, emulsion form, cream form, gel form and the like without any particular limitation on the dosage form. For example, hair lotion, hair milk It can be made into cosmetics for hair such as out bath hair products such as hair creams, hair treatments, split hair coats, and in bath hair products such as rinses, hair packs, shampoos and the like. Moreover, it can also be implemented as an aerosol hair spray or hair foam by blending a propellant. It is particularly effective in a dosage form such as a hair lotion containing a component (D) such as ethyl alcohol. That is, normally, in the dosage form in which the component (B) is blended in the emulsion composition, it becomes difficult to blend stably when the blending amount of the component (D) increases, but the vesicle composition of the present invention was used. In the dosage form, while maintaining stability over time, it is excellent in familiarity with hair, and the goodness of having the configuration of the present application is fully exhibited.

  For example, as described above, the cosmetic containing component (D) is prepared by dispersing components (A) and (B) in component (C) and then cooling to room temperature to prepare a vesicle composition. And a method comprising adding component (D) to the composition. Similarly to the preparation of the vesicle composition, the above-mentioned optional components can be appropriately added according to the properties and the like in anticipation of a feeling of use and further effects on the hair.

  EXAMPLES Next, an Example is given and this invention is demonstrated still in detail. In addition, these do not limit this invention at all.

Example 1 (Product 1 of the present invention and Comparative product 1): Vesicle composition A vesicle composition (Product 1 of the present invention) using the component (A) of the present invention according to the formulation shown in the following table and the following production method, and the components A vesicle composition (Comparative Product 1) using a general 2-long-chain quaternary alkylammonium salt type cationic surfactant instead of (A) is prepared, and the vesicle is produced by the following method. The stability over time was further evaluated by the change in vesicles (average particle diameter). The quaternary alkylammonium salt type cationic surfactant used in Comparative Product 1 is distearyldimethylammonium chloride (“Arcard 2HP-75” manufactured by Lion Akzo).

<Confirmation of vesicle generation>
Observation with a polarizing microscope (DP-70 manufactured by Olympus) under crossed Nicols was performed to confirm the presence of vesicles (the presence of a Maltese cross image serving as an indicator that vesicles were formed). In addition, regarding the obtained vesicle composition (1% phosphotungstic acid aqueous solution was added in an equal amount to a 10-fold diluted dispersion of purified water and negative staining), a transmission electron microscope (HITACHI H-7650, pressurized voltage: 80 kV) was used. And observed. The generation of vesicles can be confirmed with the formation of multilamellar vesicles having a multilayer structure as an index.
In the product 1 of the present invention, a large number of Maltese cross images, which are indicators of the formation of vesicles, are observed by observation with a polarizing microscope, and multilamellar vesicles having a multilayer structure are observed by observation with a transmission electron microscope. Observed.
A photograph of the product 1 of the present invention observed with a transmission electron microscope is shown in FIG. 1, and a photograph observed with a polarizing microscope is shown in FIG.

(Production method)
A: Components 1 to 3 are heated and dissolved at 100 ° C.
B: Component 4 is heated to 90 ° C.
C: A is added to B and mixed and stirred with a homomixer.
D: C was cooled to room temperature to obtain a vesicle composition.

<Evaluation of stability over time>
As the evaluation of stability over time, changes in the average particle diameter and state of vesicles were measured (observed) over time by the following method, and further determined using the following criteria. The results are shown in the above table.
(Evaluation method)
The vesicle composition of Invention product 1 and Comparative product 1 was heated to 60 ° C., and the inside of an extruder (Avanti Polar Lipids) equipped with a PC membrane (pore size: 200 nm manufactured by WHATMAN) was each 10 ° C. under 60 ° C. conditions. Pass through to prepare sample.
The average particle size of the prepared sample was measured using a dynamic light scattering method (Beckman Coulter N5) immediately after preparation for 3 days and 1 month in a 30 ° C. incubator.
Furthermore, the degree of change (increase) in the average particle size of the sample after one month relative to the average particle size of the sample immediately after preparation and the change in the state of the vesicle were determined using the following four-stage criteria.
<4 step criteria>
(Judgment): (Change in average particle diameter and state after one month with respect to immediately after preparation)
◎ (very good): no change is observed, or 2 times or less of the average particle size immediately after preparation ○ (good): 2 times to 5 times or less △ (somewhat poor): 5 times to 20 times or less × (Bad): More than 20 times or indeterminate state due to vesicle collapse

As is clear from the observation results of the transmission electron microscope and the polarizing microscope (FIGS. 1 and 2) and the results in the above table, the vesicle composition of the product 1 of the present invention using the component (A) is a good vesicle composition. It was formed and was excellent in stability over time.
On the other hand, the vesicle composition of Comparative Product 1 using a 2-long-chain quaternary alkylammonium salt type cationic surfactant in place of the component (A), although vesicles were formed, compared with the vesicles immediately after preparation. The average particle diameter of the vesicles after one month was greatly increased, or the vesicles were disintegrated (the particle size distribution was broadened), which was inferior in terms of stability over time.

Example 2 (Products 2 to 4 of the present invention): Vesicle composition A solution of dicocoylethylhydroxyethylmonium methosulfate (80%) propylene glycol used as component (A) in the preparation of the product 1 of the present invention was converted to dipalmitoyl. A vesicle composition was prepared in the same manner except that the ethylhydroxyethylmonium methosulfate (90%) isopropanol solution was used (hereinafter referred to as "Product 2 of the present invention"). Further, a vesicle composition was prepared in the same manner except that the molar ratio 7/3 of (A) / (B) of the product 1 of the present invention was changed to 1/4 (hereinafter referred to as “the product 3 of the present invention”). ”). Furthermore, isostearic acid was added to the product 3 of the present invention to prepare a vesicle composition (hereinafter referred to as “product 4 of the present invention”). In the same manner as in Example 1, changes in the state of vesicles were evaluated. The formulation and results are shown in Table 2 below.

(Manufacturing method of the present invention products 2 to 4)
A: Components 1 to 4 are heated and dissolved at 100 ° C.
B: Component 5 is heated to 90 ° C.
C: A is added to B and mixed and stirred with a homomixer.
D: C was cooled to room temperature to obtain a vesicle composition.

<Evaluation of penetration into hair (observation of hair cross section)>
Example 3 (Product 5 of the present invention and Comparative products 2 to 4)
Next, a fluorescent marker; pyrene-containing vesicle composition (sample) was prepared by the formulation shown in the following table and the following production method, and the penetration into the hair was evaluated by the following method.

(Production method)
A: Components 1 to 5 are dissolved by heating at 100 ° C.
B: Component 6 is heated to 90 ° C.
C: A is added to B and mixed and stirred with a homomixer.
D: C was cooled to room temperature to prepare a sample.

(Evaluation method)
(1) A hair bundle (hair) is immersed in a sample such as the pyrene-containing vesicle composition prepared by the above table and the above manufacturing method for 12 hours. (2) The hair is taken out from (1), embedded in resin, and crossed by a microtome. Surface section preparation (3) The section of the hair cross section of (2) was observed with a fluorescence microscope (observation conditions of the fluorescence microscope: excitation filter: 330-385 nm, fluorescence filter: 420 nm, exposure time: 0.20 S). With respect to the obtained vesicle composition, the penetrability of pyrene, which is a fluorescent marker, into the hair was evaluated to evaluate the permeability of the vesicle composition (cholesterol) into the hair.

The result (photograph) observed with the fluorescence microscope of (3) is shown in FIG.
3, FIG. 3-1, FIG. 3-2, FIG. 3-3, and FIG. 3-4 show the product 5 of the present invention, the comparative product 2 (fluorescent marker; no pyrene added), and the comparative product 3 respectively. It is sectional drawing of the hair immersed in the sample of the comparative product 4. FIG.
In the photograph of FIG. 3, the portion that is shining blue (the portion that appears white in the black-and-white drawing) indicates that pyrene, which is a fluorescent marker, is present.
From the photograph of FIG. 3, FIG. 3-2 immersed in the comparative product 2 containing no pyrene hardly shows anything (the shape of the hair cross section is not known), and the comparative product is simply added to the hydrocarbon oil. Fig. 3-3 immersed in 3 only looks blue (approximally white in black and white drawings) so that the state of the hair cross-section can be clearly understood, and instead of component (A), it is a quaternary alkylammonium salt type cationic compound having two long chains 3-4 immersed in comparative product 4 using a surfactant is slightly different from the one immersed in comparative product 3, although the bluish whiteness (whiteness in black and white drawings) is stronger and the state of the hair cross section can be understood. You can see that there is no.
On the other hand, FIG. 3-1, immersed in the vesicle composition of the product 5 of the present invention, is clearly pale in color as a whole hair cross section (white in the black-and-white drawing) compared to the one immersed in the above comparative test example. It is shining well.
That is, it can be seen that the vesicle composition of the product 5 of the present invention prepared using the component (A) has very high permeability into the hair.
This is because the component (A) has a microscopic polarity due to the ester bond in the lipophilic group, and thus the membrane fluidity of the vesicle membrane (deformability of the vesicle membrane) is excellent, It is thought that it penetrated easily and therefore high permeability was exhibited.

(Experimental conditions and results regarding water retention capacity)
Further, the product 5 of the present invention prepared above was permeated into the hair, and the binding water ratio in the hair was quantified. The result is shown in FIG. This effect relates to the effect of imparting a moist feeling to the hair of a hair cosmetic (hair lotion). For the measurement, a near-infrared spectrophotometer “Spectrum 400” (manufactured by Perkin Elmer) was used, and a hair bundle (about 5 g) made of the same human hair was used as a test sample. Specifically, it is as follows.
The product 5 of the present invention was applied to a hair bundle and dried well to obtain a hair sample. As a comparative control product, purified water was applied to a hair bundle (about 5 g) of the same human hair, and a well-dried reference hair sample was obtained. Near-infrared spectroscopic measurement was performed in the range of 5350 cm ^{−1 to} 4950 cm ⁻¹ , and the peak area of the obtained spectrum was applied to the following formula 1 to determine the bound water ratio in the hair.
Formula 1
Bonded water ratio (%) = {peak area 1 / (peak area 1 + peak area 2)} × 100
Peak area 1 (5150 cm ^{−1 to} 4950 cm ⁻¹ ): Strong bound water (means that moisture transpiration hardly occurs from hair)
Peak area 2 (5350 cm ^{−1 to} 5150 cm ⁻¹ ): Weak bound water (means that water is likely to evaporate from the hair)

  From the results shown in FIG. 4, it is understood that the binding water ratio in the hair of the hair sample applied with the product 5 of the present invention is significantly increased compared to the reference hair sample applied with purified water. it can. This indicates that the moisture retention ability of the hair has been improved by applying the product 5 of the present invention, that is, it can be understood that this effect is due to the moist feeling imparted to the hair.

Example 4
(Stability evaluation of vesicle composition over time)
Vesicle sample 1 obtained by dispersing 1 part by mass of dipalmitoylethylhydroxyethylmonium methosulphate (DEQ) in 99 parts by mass of water (ie, DEQ / CL = 10/0 (molar ratio)), DEQ, and cholesterol ( CL) and a vesicle sample 2 obtained by dispersing 1 part by mass in 99 parts by mass of water (that is, DEQ / CL = 7/3 (molar ratio)), A vesicle sample 3 obtained by dispersing 1 part by mass of distearyldimethylammonium chloride (DSAC) in 99 parts by mass of water (that is, DSAC / CL = 10/0 (molar ratio)), DSAC, and CL were added in moles. Vesicle sample 4 (ie, DSAC / CL = 7/3 (molar ratio) obtained by premixing at a ratio of 7/3 and dispersing 1 part by weight in 99 parts by weight of water. )) Was prepared, respectively. The reagents used for preparing each sample are the same as the reagents used in Example 1, respectively.

In preparing each sample, each component was dissolved in tetrahydrofuran (THF), then the solvent (THF) was removed with a rotary evaporator, heated to 80 ° C., purified water was poured, and a probe-type ultrasonic irradiator “VCX130PB” (Manufactured by SONIC & MATERIALS) was prepared by ultrasonic irradiation for 30 minutes. The solid content concentration of each obtained sample was unified to 1% by mass. The obtained vesicle dispersion was treated with an extruder a plurality of times to make the average particle size uniform, and the change in the average particle size over time was observed.
In addition, each sample was observed with a polarizing microscope, and at the initial stage, a Martelose cross image was confirmed, that is, it was confirmed that a vesicle was formed.

The results are shown in FIGS. 5 and 6, respectively.
From the results shown in FIG. 5, in the vesicle composition containing dipalmitoylethylhydroxyethylmonium methosulphate (DEQ) which is an example of the component (A) according to the present invention, the sample 2 to which cholesterol was added added cholesterol. It can be understood that the diameter of the vesicle particles does not vary and the stability over time is excellent as compared with the sample 1 that is not.
On the other hand, from the results shown in FIG. 6, in the vesicle composition containing distearyldimethylammonium chloride (DSAC) having a long-chain alkyl group not containing an ester bond, the time-dependent stability of Sample 4 is significantly reduced by the addition of cholesterol. I can understand.

The vesicle sample 1 prepared above (ie, DEQ / CL = 10/0 (molar ratio)) and the vesicle sample 2 (ie, DEQ / CL = 7/3 (molar ratio)) are differentially scanned. Since the calorific value was measured, the result is shown in FIG. In addition, "DSC7020" (SII company) was used for the measurement, the measurement was performed in the range of 30 ° C to 110 ° C with aluminum oxide powder as the reference substance and the temperature raising condition of 1 ° C / min.
From the DSC curve shown in FIG. 7, the endothermic peak (the part surrounded by a circle in the figure) accompanying the gel-liquid crystal transition of DEQ observed in the vesicle sample 1 from 35 ° C. to 45 ° C. disappears in the vesicle sample 2. This indicates that DEQ and CL are compatible at the molecular level, and a thermally stable gel-liquid crystal intermediate is formed.

Example 5 (Invention Products 6 to 10 and Comparative Products 5 to 7): Hair Cosmetic (Hair Lotion)
Prepare hair cosmetics by the following formulation and the following manufacturing method shown in the following table, and (i) stability over time, (b) familiarity with hair, (c) penetration into hair, and (d) moist feeling. The application was evaluated by the following method. The results are also shown in the following table.

(Production method)
A: Components 1 to 5 are dissolved by heating at 100 ° C.
B: Component 8 is heated to 90 ° C.
C: A is added to B and mixed and stirred with a homomixer.
D: Cool C to room temperature.
E: 6 and 7 were added to D to obtain a cosmetic for hair (hair lotion).

(Evaluation method)
(I) Stability over time Stability over time was determined (evaluated) by the same method as in Example 1 above.

(Evaluation method)
(B) Familiarity with hair (c) Penetration feeling inside hair (d) Moisturizing test A ten-special panel test was conducted to (b) Familiarity with hair, (c) Penetration feeling inside hair (D) The moist feeling was evaluated by absolute evaluation according to the following five-stage evaluation criteria, the average value was calculated from the scores of all the panels for each sample, and further determined according to the following four-step evaluation criteria.
<5-level evaluation criteria>
(Score): (Evaluation)
5 points: feels very good / very strong 4 points: feels good / strong 3 points: normal / feels slightly 2 points: slightly bad / not very felt 1 point: bad / not felt <4-step criteria>
(Judgment): (Average score)
◎: More than 4.5 points ○: More than 3.5 points and less than 4.5 points △: More than 1.5 points and less than 3.5 points ×: 1.5 points or less

As is apparent from the results shown in the above table, all of the hair cosmetics of the present invention products 6 to 10 are superior in stability over time compared to the hair cosmetic products of comparative products 5 to 7, and quickly become familiar when applied to hair. It was possible to realize a permeation feeling that the cosmetic penetrated into the hair and was excellent in imparting a moist feeling. In particular, the products 9 and 10 of the present invention, which are blended with the component (D) that tends to make it difficult to ensure stability over time, are familiar with hair, have a penetrating feeling inside the hair, and have a moist feeling. In addition to excellent feeling of use, such as imparting, it exhibits sufficient stability over time, and in particular, the product 9 of the present invention containing ethyl alcohol as the component (D) quickly and smoothly blends into the hair when applied and is extremely penetrating. It was excellent in feeling.
On the other hand, comparative products 5 and 7 using a general 2-long-chain quaternary alkyl ammonium salt type cationic surfactant include comparative product 6 containing stearyl alcohol instead of component ( B ). The stability over time was poor and the penetration into the hair was poor.
Moreover, the comparative product 4 using a higher alcohol instead of the component (B) is inferior in imparting a moist feeling with poor temporal stability and a sense of penetration into the hair even when the component (A) is used. there were.

Example 6: Vesicle composition (component) (%)
1. Dipalmitoylhydroxyethylmonium methosulfate 90% isopropanol solution * 4 3
2. Phytosterol * 5 0.36
3. 1,2-pentanediol 5
4). Purified water remaining amount * 4: DEHYQUAT AU56 / G (Molecular weight: 751 manufactured by Cognis)
* 5: Phytosterol (Eisai's average molecular weight: 409.4)

(Production method)
A: Components 1 to 3 are heated and dissolved at 100 ° C.
B: Component 4 is heated to 90 ° C.
C: A is added to B and emulsified with a homomixer.
D: C was cooled to room temperature to obtain a vesicle composition.

The vesicle composition of Example 6 was evaluated in the same manner as in Example 1. As a result, good vesicles were formed and a Maltese cross image was observed. In addition, the change in average particle diameter with time was small, and the stability was excellent.
In the vesicle composition of Example 6, the molar ratio (A) / (B) of component (A) to component (B) was 4 (A) / (B).

Example 7: Hair cosmetic (hair milk)
(Ingredient) (%)
1. Dicocoylethylhydroxyethylmonium methosulfate 80% propylene glycol solution * 1 3
2. Cholesterol * 3 0.75
3. Olive oil 0.75
4). Propylene glycol 5
5. Purified water remaining

(Production method)
A: Components 1, 2, and 3 are heated and dissolved at 100 ° C.
B: Component 5 is heated to 90 ° C.
C: A is added to B and mixed and stirred with a homomixer.
D: C is cooled to room temperature to obtain a vesicle composition.
E: Add component 4 to D and cool to room temperature.
F: E was put in a container to obtain a cosmetic for hair (hair milk).

About the cosmetics for hair (hair milk) of Example 7, when evaluated by the same method as Example 1 and Example 3, a Maltese cross image was observed and it turned out that the favorable vesicle is formed. Moreover, it was excellent in all of the stability over time, the familiarity with hair, the penetrating feeling and the moist feeling.
In addition, in the cosmetic for hair (hair milk) of Example 7, molar ratio (A) / (B) of a component (A) and a component (B) was 1.8.

Example 8: Hair cosmetic (hair lotion)
(Ingredient) (%)
1. Dicocoylethylhydroxyethylmonium methosulfate 80% propylene glycol solution * 1 3
2. Cholesterol * 3 0.36
3. Purified water 30
4). Dimethylpolysiloxane (100CS) 0.5
5. Isostearic acid 0.54
6). Propylene glycol 5
7). Ethyl alcohol 5
8). Purified water remaining 9. Fragrance 0.1

(Production method)
A: Components 1, 2, and 5 are heated and dissolved at 100 ° C.
B: Component 3 is heated to 90 ° C.
C: A is added to B and mixed and stirred with a homomixer.
D: C is cooled to room temperature to obtain a vesicle composition.
E: Components 4 and 6 are added to D and mixed uniformly.
F: Components 7 to 9 are added to E and mixed uniformly.
G: F was filled in a container to obtain a hair cosmetic (hair lotion).

About the cosmetics for hair (hair lotion) of Example 8, when evaluated by the same method as Example 1 and Example 3, a favorable Maltese cloth image was observed and it was confirmed that a favorable vesicle was formed. all right. Moreover, it was excellent in all of the stability over time, the familiarity with hair, the penetrating feeling and the moist feeling.
In the hair cosmetic composition of Example 8, the molar ratio (A) / (B) of the component (A) to the component (B) was 3.8.

Example 9: Hair cosmetic (hair essence)
(Ingredient) (%)
1. Inventive product 1 vesicle composition 90
2. Purified water 4.6
3. Glycerin 5
4). Sorbitol 0.1
5. Glycine 0.1
6). Seaweed extract 0.1
7). Fragrance 0.1

(Production method)
A: Components 1 and 2 are mixed uniformly at room temperature.
B: Components 3 to 6 and 7 are added to A and mixed uniformly.
C: B was filled in a container to obtain a hair cosmetic (hair essence).

  The hair cosmetic of Example 9 (hair essence) was evaluated in the same manner as in Example 3. As a result, it was excellent in all of the stability over time, the familiarity with the hair, the penetration feeling, and the moist feeling. there were.

Example 10: Hair cosmetic (hair mist)
(Ingredient) (%)
1. Vesicle composition of Example 6 1
2. Hydrolyzed collagen solution 0.3
3. Purified water remaining

(Production method)
A: Components 1 to 3 are mixed uniformly at room temperature.
B: A cosmetic material for hair was obtained by filling A into a mist container.

  The hair cosmetic composition of Example 10 (hair mist) was evaluated in the same manner as in Example 3. The hair cosmetic composition was excellent in all of the stability over time, the familiarity with the hair, the penetrating feeling, and the moist feeling. It was.

Example 11: Moisturizing cosmetic for body (ingredient) (%)
1. Vesicle composition of product 4 of the present invention 0.5
2. L-theanine 0.1
3. Sodium hyaluronate (1% aqueous solution) 5.0
4). Purified water remaining

(Production method)
A: Components 1 to 4 are uniformly mixed at room temperature.
B: A container was filled with A to obtain a moisturizing cosmetic for body.

  The body moisturizing cosmetic of Example 11 was evaluated in the same manner as in Example 3. As a result, it was excellent in all of the stability over time, the familiarity with the skin, the penetrating feeling and the moist feeling.

Claims (4)

The following components (A) to (C),
(A) a cationic surfactant selected from the group consisting of dicocoylethylhydroxyethylmonium methosulfate and dipalmitoylethylhydroxyethylmonium methosulfate (B) cholesterol and / or phytosterol (C) containing water. A vesicle composition characterized in that the molar ratio (A) / (B) of component (A) to component (B) is in the range of 100/1 to 1/4 . A cosmetic comprising the vesicle composition according to claim 1 . The cosmetic according to claim 2 , wherein the cosmetic is for hair. Furthermore, monovalent | monohydric lower alcohol is mix | blended as a component (D), The cosmetics of Claim 2 or 3 characterized by the above-mentioned.