TW201032734A - Nutritional composition for infants - Google Patents
Nutritional composition for infants Download PDFInfo
- Publication number
- TW201032734A TW201032734A TW098146464A TW98146464A TW201032734A TW 201032734 A TW201032734 A TW 201032734A TW 098146464 A TW098146464 A TW 098146464A TW 98146464 A TW98146464 A TW 98146464A TW 201032734 A TW201032734 A TW 201032734A
- Authority
- TW
- Taiwan
- Prior art keywords
- ala
- nutritional composition
- acid
- content
- obesity
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 66
- 235000016709 nutrition Nutrition 0.000 title claims abstract description 32
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims abstract description 165
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims abstract description 77
- 229960004488 linolenic acid Drugs 0.000 claims abstract description 76
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims abstract description 42
- 235000020778 linoleic acid Nutrition 0.000 claims abstract description 42
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims abstract description 42
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 22
- 229930195729 fatty acid Natural products 0.000 claims abstract description 22
- 239000000194 fatty acid Substances 0.000 claims abstract description 22
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 22
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 21
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 21
- 150000002632 lipids Chemical class 0.000 claims abstract description 14
- 150000001720 carbohydrates Chemical class 0.000 claims abstract description 9
- 235000019197 fats Nutrition 0.000 claims description 25
- 208000008589 Obesity Diseases 0.000 claims description 16
- 235000020824 obesity Nutrition 0.000 claims description 16
- 238000004519 manufacturing process Methods 0.000 claims description 6
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims description 5
- 206010033307 Overweight Diseases 0.000 claims description 4
- 206010036790 Productive cough Diseases 0.000 claims description 4
- 210000003802 sputum Anatomy 0.000 claims description 4
- 208000024794 sputum Diseases 0.000 claims description 4
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 1
- 239000005642 Oleic acid Substances 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 description 23
- 102000007544 Whey Proteins Human genes 0.000 description 20
- 108010046377 Whey Proteins Proteins 0.000 description 20
- 235000005911 diet Nutrition 0.000 description 20
- 230000037213 diet Effects 0.000 description 19
- 235000018102 proteins Nutrition 0.000 description 18
- 239000005862 Whey Substances 0.000 description 16
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 16
- 210000004027 cell Anatomy 0.000 description 14
- 229940088594 vitamin Drugs 0.000 description 14
- 229930003231 vitamin Natural products 0.000 description 14
- 235000013343 vitamin Nutrition 0.000 description 14
- 239000011782 vitamin Substances 0.000 description 14
- 241001465754 Metazoa Species 0.000 description 12
- 235000009508 confectionery Nutrition 0.000 description 10
- 210000001789 adipocyte Anatomy 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 241000700198 Cavia Species 0.000 description 8
- 102000004877 Insulin Human genes 0.000 description 8
- 108090001061 Insulin Proteins 0.000 description 8
- 229940125396 insulin Drugs 0.000 description 8
- 235000014633 carbohydrates Nutrition 0.000 description 7
- 229910052500 inorganic mineral Inorganic materials 0.000 description 7
- 210000004185 liver Anatomy 0.000 description 7
- 239000011707 mineral Substances 0.000 description 7
- 235000010755 mineral Nutrition 0.000 description 7
- 241000024188 Andala Species 0.000 description 6
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 6
- 230000004663 cell proliferation Effects 0.000 description 6
- 238000011161 development Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 5
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 5
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 description 5
- 210000001596 intra-abdominal fat Anatomy 0.000 description 5
- 230000006651 lactation Effects 0.000 description 5
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 5
- 150000003722 vitamin derivatives Chemical class 0.000 description 5
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- 102000016267 Leptin Human genes 0.000 description 4
- 108010092277 Leptin Proteins 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 239000005018 casein Substances 0.000 description 4
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 4
- 235000021240 caseins Nutrition 0.000 description 4
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 4
- 201000010063 epididymitis Diseases 0.000 description 4
- NRYBAZVQPHGZNS-ZSOCWYAHSA-N leptin Chemical compound O=C([C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CC(C)C)CCSC)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(O)=O NRYBAZVQPHGZNS-ZSOCWYAHSA-N 0.000 description 4
- 229940039781 leptin Drugs 0.000 description 4
- 235000015097 nutrients Nutrition 0.000 description 4
- 206010033675 panniculitis Diseases 0.000 description 4
- 230000035755 proliferation Effects 0.000 description 4
- 210000004003 subcutaneous fat Anatomy 0.000 description 4
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 4
- 235000021119 whey protein Nutrition 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 3
- 238000009825 accumulation Methods 0.000 description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 3
- 210000001185 bone marrow Anatomy 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000003995 emulsifying agent Substances 0.000 description 3
- 210000000918 epididymis Anatomy 0.000 description 3
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 3
- 239000011777 magnesium Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 210000002966 serum Anatomy 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 3
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 2
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- 229930003471 Vitamin B2 Natural products 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 235000021342 arachidonic acid Nutrition 0.000 description 2
- 229940114079 arachidonic acid Drugs 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 239000000828 canola oil Substances 0.000 description 2
- 235000019519 canola oil Nutrition 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 235000013351 cheese Nutrition 0.000 description 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 2
- 229960001231 choline Drugs 0.000 description 2
- 239000010949 copper Substances 0.000 description 2
- 235000020776 essential amino acid Nutrition 0.000 description 2
- 239000003797 essential amino acid Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 229960000304 folic acid Drugs 0.000 description 2
- 235000019152 folic acid Nutrition 0.000 description 2
- 239000011724 folic acid Substances 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 2
- 235000020256 human milk Nutrition 0.000 description 2
- 210000004251 human milk Anatomy 0.000 description 2
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 2
- 229960000367 inositol Drugs 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 229940055726 pantothenic acid Drugs 0.000 description 2
- 235000019161 pantothenic acid Nutrition 0.000 description 2
- 239000011713 pantothenic acid Substances 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- 229960002477 riboflavin Drugs 0.000 description 2
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000008347 soybean phospholipid Substances 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 229960003080 taurine Drugs 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 235000019164 vitamin B2 Nutrition 0.000 description 2
- 239000011716 vitamin B2 Substances 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- 239000011701 zinc Substances 0.000 description 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 1
- HMNVFLLOGIZHSI-UHFFFAOYSA-N 4-(2,3-dihydroxypropoxy)-2-[2-(2,3-dihydroxypropoxy)-2-oxoethyl]-2-hydroxy-4-oxobutanoic acid Chemical compound OCC(O)COC(=O)CC(O)(C(O)=O)CC(=O)OCC(O)CO HMNVFLLOGIZHSI-UHFFFAOYSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 235000017060 Arachis glabrata Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- 235000010777 Arachis hypogaea Nutrition 0.000 description 1
- 235000018262 Arachis monticola Nutrition 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 239000004381 Choline salt Substances 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 230000004543 DNA replication Effects 0.000 description 1
- 230000006820 DNA synthesis Effects 0.000 description 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 1
- 206010015719 Exsanguination Diseases 0.000 description 1
- 208000002705 Glucose Intolerance Diseases 0.000 description 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 description 1
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 208000015580 Increased body weight Diseases 0.000 description 1
- 206010022489 Insulin Resistance Diseases 0.000 description 1
- PIWKPBJCKXDKJR-UHFFFAOYSA-N Isoflurane Chemical compound FC(F)OC(Cl)C(F)(F)F PIWKPBJCKXDKJR-UHFFFAOYSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- 102000010445 Lactoferrin Human genes 0.000 description 1
- 108010063045 Lactoferrin Proteins 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- 229920002774 Maltodextrin Polymers 0.000 description 1
- 208000001145 Metabolic Syndrome Diseases 0.000 description 1
- 241001139947 Mida Species 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 238000010793 Steam injection (oil industry) Methods 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 229930003316 Vitamin D Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 229960005069 calcium Drugs 0.000 description 1
- 230000005800 cardiovascular problem Effects 0.000 description 1
- 229960004203 carnitine Drugs 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229910052805 deuterium Inorganic materials 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000021004 dietary regimen Nutrition 0.000 description 1
- 229940090949 docosahexaenoic acid Drugs 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 235000004626 essential fatty acids Nutrition 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000013350 formula milk Nutrition 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 210000002490 intestinal epithelial cell Anatomy 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 229960002725 isoflurane Drugs 0.000 description 1
- CSSYQJWUGATIHM-IKGCZBKSSA-N l-phenylalanyl-l-lysyl-l-cysteinyl-l-arginyl-l-arginyl-l-tryptophyl-l-glutaminyl-l-tryptophyl-l-arginyl-l-methionyl-l-lysyl-l-lysyl-l-leucylglycyl-l-alanyl-l-prolyl-l-seryl-l-isoleucyl-l-threonyl-l-cysteinyl-l-valyl-l-arginyl-l-arginyl-l-alanyl-l-phenylal Chemical compound C([C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)C1=CC=CC=C1 CSSYQJWUGATIHM-IKGCZBKSSA-N 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 235000021242 lactoferrin Nutrition 0.000 description 1
- 229940078795 lactoferrin Drugs 0.000 description 1
- 235000020978 long-chain polyunsaturated fatty acids Nutrition 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 235000021416 maternal diet Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 239000002777 nucleoside Substances 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 235000020232 peanut Nutrition 0.000 description 1
- 230000009984 peri-natal effect Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 210000000229 preadipocyte Anatomy 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000000574 retroperitoneal space Anatomy 0.000 description 1
- 238000001223 reverse osmosis Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 235000021055 solid food Nutrition 0.000 description 1
- 235000015096 spirit Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 210000005167 vascular cell Anatomy 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- DTOSIQBPPRVQHS-UHFFFAOYSA-N α-Linolenic acid Chemical compound CCC=CCC=CCC=CCCCCCCCC(O)=O DTOSIQBPPRVQHS-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pediatric Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Obesity (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
201032734 六、發明說明: 【發明所屬之技術領域】 本發明係關於一種營養組合物,更具體言之係關於一種 嬰兒用之營養組合物’其有助於降低日後罹患肥胖症之風 險。 【先前技術】 向所有嬰兒推薦母乳。然而在一些情況下,由於若干醫 ❹學原因,母乳餵養係不充足或不成功或不聽勸告或母親根 本未選擇母乳餵養或未選擇母乳餵養之時間超過數週。針 對該等情況’已研發嬰兒配方。 在美國及全球範圍内,成年人、兒童及青少年中肥胖症 及超重的普遍性已於過去30年内快速增長且仍在不斷上 升。目岫,兒里期超重及肥胖在全球範圍内影響18〇〇萬名 5歲以下兒童。近30%美國兒童及青少年及1〇至3〇%之歐洲 兒童超重或肥胖。 # 曰益認爲出生頭6個月係人類脂肪質量發展之最重要產 後期之’因此係日後漸進形成過度肥胖之關鍵時期。此 外,人類流行病學數據及動物研究證實,於出生時或嬰兒 期間所增加的體重與曰後罹患諸如代謝综合症、2型糖尿 病及心血管問題之疾病的風險相關。 版他⑽等人研究母親膳食中亞油酸(LA)對α•亞麻酸 (ALA)之比率對其喷乳幼畜期間之血清瘦素漢度之影響, 並發現與彼等其母親食用同時含LA及ALA(LA/ALA比為 9.0)之腾食的幼畜相比,對母㈣以富含ala(la/ala比 145394.doc 201032734 為0.42)之膳食時,接受哺乳之幼畜之企清瘦素濃度較低。 母親食用富含LA(LA/ALA比為216)之膳食的第三組幼畜之 平均血清痩素濃度係介於其他兩組濃度之間,但彼此無明 顯差異。因先前大量研究已顯示,在圍產期之循環瘦素濃 度對正常發育及健康具重要作用·,所以作者選擇研究幼畜 的血清痩素濃度。基於該等發現,繼而預測母親膳食中 LA與ALA間的平衡而非LA或ALA本身之量對脂肪組織生 長具重要作用(Korotkova,等人,「Leptin levels in rat offspring are modified by the ratio of linoleic to a-linolenic acid in the maternal diet」,Journal of Lipid Research, 43 卷,2002, 1743-1749頁)。 於W02008/054192中,主張嬰兒的總脂肪組織質量並非 確定日後患病風險的良好預測值,反而應注意嬰兒早期所 累積的内臟脂肪質量。已證明内臟脂肪細胞量主要係於嬰 兒期内確定,且W02008/054192之發明者確信,在此期間 控制内臟脂肪生成為有用之作法。W02008/054192中所建 議的方案係降低餵養嬰兒之LA量,以使LA/ALA比介於2 與6之間,同時保證LA量低於總脂肪酸之14_5重量%。 然而,由於LA及ALA均係必需脂肪酸,亦即無法由人體 合成之脂肪酸,因此就人類嬰兒的營養方面,此方法可能 受到實際應用之限制。 因此,顯然需要一種旨在兒童期減少脂肪質量累積,進 而降低日後罹患肥胖症之風險及罹患與該肥胖症相關的疾 病之風險的替代營養方法。 145394.doc 201032734 【發明内容】 本發明者已出人意料地發現,於嬰兒期餵食相對富含α_ 亞麻酸之組合物會減少日後總脂肪質量的累積。 因此,本發明提供一種營養組合物,其包含一種蛋白質 源、種月曰質源及一種碳水化合物源,其中以佔總脂肪酸 含量之百分比表示,該脂質源分別包含至少丨6重量%亞油 酸及至少2重量% α·亞麻酸,且其含量使亞油酸:α_亞麻 ❹ 酸之比例介於1至10之間。 本發明亦提供一種以亞油酸及α-亞麻酸於製造一種用於 投與初生6個月内的嬰兒的營養組合物,以降低日後發展 成肥胖症風險上之用途,其中該組合物以佔該組合物中總 脂肪酸含量之百分比表示,分別包含至少16重量%亞油酸 及至少2重量% α_亞麻酸,且其含量使亞油酸:α_亞麻酸 之比介於1至10之間。 本發明進一步提供一種降低嬰兒日後罹患肥胖症之風險 粵之方法,其包括對出生6個月内的嬰兒飯養-種營養組合 物,*亥營養組合物包含一種蛋白質源、一種脂質源及一種 碳水化合物源,其中以佔總脂肪酸含量之百分比表示該 月曰質源分別包含至少丨6重量%亞油酸及至少2重量% α_亞麻 酸且其含量以使亞油酸:α-亞麻酸之比例介於1至1〇之 間。 在不欲受理論之侷限下,依據其實驗觀察,本發明者確 仏’嬰兒期健養富含〜亞麻酸之膳食可依某種方式減少脂 W生成且減少脂肪細胞之尺寸增大中任一項或兩項,且此 145394.doc 201032734 等效益可持續至日後,進而降低日後罹患肥胖症之風險。 此外,已知肥胖症與增加諸如可能發展為2型糖尿病之胰 島素抵抗及葡萄糖失耐的病況之風險相關。 【實施方式】 於本說明書中,以下表述具有如下定義: 「ALA」意指α-亞麻酸(ci8:3n-3); 「嬰兒」意指未滿12個月之兒童,且「嬰兒期」應相應 地理解;就本發明之目的而言,術語「嬰兒」包含幼嬰動 物,如幼寵物、幼犬、幼馬或幼貓。 「LA」意指亞油酸(ci8:2n-6); 就嬰兒而言’「日後」意指嬰兒期之後生命中的任何時 間點。此時間點之一實例可為脂肪細胞反彈時之年齡,其 一般於人類嬰兒的5至6歲期間發生。 除非另外說明外,否則所有百分比及比例皆為重量比。 根據本發明之營養組合物包含至少16重量%LA及至少2 重量% ALA。LA含量較佳介於總脂肪酸之18至3〇%之間, 更佳係介於18至25%之間。ALA含量較佳係介於總脂肪酸 之2至12%之間,更佳係介於6至11%之間。la:ala比例較 佳係介於2至6之間。 本發明之營養組合物較佳具有小於i 85 g/1〇〇 “a丨之蛋 白質含量。只要滿足對於必需胺基酸含量之最低需求且確 保令人滿意的生長,則認爲蛋白質源之具體組成對本發明 並不重要。因此,可使用基於諸如乳清、酪蛋白及其混合 物的牛奶蛋白質之蛋白質源’以及基於大豆的蛋白質源。 145394.doc 201032734 然而,以乳清與酷·蛋白蛋白質之混合物為較佳。路蛋白: 乳清比可介於70:30至30:70之間,但較佳係30:70。 蛋白質源中之蛋白質可係完整或經部分水解,或可使用 完整蛋白質與水解蛋白質之混合物。若需滿足對必需胺基 酸含量之最低需求,則該蛋白質源可另補充游離胺基酸。 此等需求已於例如EC Directive 2006/141/EC中公佈。 如上所述,較佳蛋白質源係酪蛋白與乳清蛋白之混合 φ 物。該乳清蛋白可係乳清蛋白分離物、酸乳清、甜乳清或 其中已移除酪蛋白-糖巨肽之甜乳清(經改質的甜乳清)。然 而,乳清蛋白較佳係經改質的甜乳清。甜乳清係製作乾酪 之易得的副產品且常用於製造基於牛奶的營養組合物。然 而,甜乳清包含一種稱為酪蛋白-糖巨肽(CGMP)之組份, 該組分不幸地富含蘇胺酸且缺乏色胺酸。自甜乳清中去除 CGMP得到一種蘇胺酸含量更接近人乳之蛋白質。EP 880902中闡述一種自甜乳清中去除CGMP之製程。 ❹ 若經改質的甜乳清在70%乳清與30%酪蛋白混合物中作 為乳清蛋白質時,則該蛋白質源可補充之游離組胺酸量為 總蛋白質含量的0.1至0.3%。 本發明之營養組合物含有碳水化合物源。該碳水化合物 源較佳係乳糖,但亦可添加諸如蔗糖、麥芽糊精、及澱粉 的其他碳水化合物。該營養組合物中碳水化合物含量較佳 係介於9與14g/100kcal之間。 本發明之營養組合物含有脂質源。除LA及ALA外,該脂 質源可包括適用於餵養嬰兒之營養組合物之任何脂質或脂 145394.doc 201032734 肪。較佳脂肪源包括椰子油、低芥酸菜籽油(菜軒、、由 (canola oil))、大豆卵磷脂、棕櫚油精、及葵花油。脂質原 亦可包括少量預形成的長鏈多不飽和脂肪酸花生四稀酸 (C20:4n-6)及二十二碳六稀酸(C22:6n-3)。魚油係適宜的_ 十二碳六烯酸源’或單細胞微生物油係適宜的花生四稀酸 及—十一喊六稀酸之來源。總而言之,脂質含量可人、 4.4與6 g/100 kcal之間。脂質源中花生四烯酸:二一 丁一- 六稀酸之比例較佳係介於2 : 1與1 : 1之間。 該營養組合物亦可含有營養上有意義量之日常膳食所必 需的所有維生素及礦物質。某些維生素及礦物質已建立最 低需求。視情況存在於該營養組合物中之礦物質、維生素 及其他營養素的實例包括維生素A、維生素Βι、維生素 B2、維生素&、維生素Bu、維生素E、維生素κ、維生素 C、維生素〇、葉酸、肌醇、菸酸、生物素、泛酸、膽 鹼、鈣、磷、碘、鐵、鎂、銅、鋅、錳、氯化物、鉀、 鈉、硒、鉻、鉬、牛磺酸、及L_肉鹼。礦物質通常以鹽形 式加入。 若有必要’該營養組合物可含有如大豆卵磷脂、單_及 雙-檸檬酸甘油酯等之乳化劑與安定劑。尤其當該組合物 呈液體形式提供時。 該營養組合物可視情況含有具有有利效果的其他物質, 如’依餵養嬰兒之營養組合物中常用量之益生菌、纖維、 乳鐵蛋白、核苷酸、核苷等。 該營養組合物可依任何適宜方式製得。例如,使蛋白質 145394.doc 201032734 源、碳水化合物源及脂質源依適當比例混合在一起,製得 營養組合物。若使用乳化劑,可在此階段混入該混合物 中。此時可加入維生素與礦物質’但通常較遲加入,以避 免熱降解。可先將任何親脂性維生素、乳化劑等溶於脂肪 源中,然後混合。隨後可將水(較佳為經逆滲透之水)混合 於其中,形成液體混合物。 隨後可熱處理該液體混合物’從而減少細菌量。例如, •可將該液體混合物迅速加熱至約8〇°C與約not之間的溫 度,保持約5秒至約5分鐘。可藉由蒸汽注入或熱交換器 (例如板式熱交換器)進行。 隨後可將該液體混合物冷卻至約6〇〇c與約85t>c之間;例 如藉由閃蒸冷卻。隨後可例如以兩階段均質化該液體混合 物;第一階段約7 MPa至約40 MPa及第二階段約2 Mpa至 約14 MPa。隨後可將該經均質化的混合物進一步冷卻,並 可加入任何熱敏感性組份(如維生素與礦物質)。宜在此時 參調整該均質化混合物之pH與固形物含量至標準量。 若需要製得粉末狀組合物,將經均質化的混合物移至適 宜的乾燥裝置(如喷霧乾燥器或冷凍乾燥器)且轉變為粉 末。該粉末應具有少於約5重量%之含水量。 若需製得液體組合物’將經均質化的混合物填充至適宜 的容器(較佳無菌)中。然而,亦可在容器中殺菌該液體組 合物。適宜進行此填充性質之裝置可於市面上購得。該液 體組合物可呈固形物含量約i 0至約i 4重量。/〇之現成可德養 之組合物形式,或可呈濃縮物形式;通常其固形物含量為 145394.doc 201032734 約20至約26重量%。 現將參照以下實例進一步說明本發明。 實例1 以下出示根據本發明營養組合物之組成實例: 營養素 每 100 kcal 每公升 能量(kcal) 100 630 蛋白質(g) (脫脂奶粉, 經改質的甜乳清) 游離組胺酸(mg) 酪蛋白:乳清之比例 1.5 2.5 40:60 9.45 15.8 40:60 脂肪(g) 亞油酸ig) α·亞麻酸(g) DHA(mg) ARA(mg) 亞油酸:α-亞麻酸 5.3 1.0 0.5 11.5 11.5 2 33.4 6.6 3.3 72.5 72.5 2 乳糖(g) 11.6 73.1 礦物質及電解質 Na(mg) 25 158 K(mg) 89 561 Cl(mg) 64 403 Ca(mg) 64 403 P(mg) 32 202 Ca/P 2.0 2.0 Mg(mg) 6.9 43.5 Μη(μβ) 8.0 50.4 維生素及微量元素 維生素A(IU) 350 2205 維生素D(IU) 60 378 維生素E(IU) 1.2 7.6 維生素Κ1(μ8) 8.0 50.4 維生素C(mg) 10 63 維生素Bl(mg) 0.07 0.44 維生素B2(mg) 0.15 0.95 终酸(mg) 1.0 6.3 維生素B6(mg) 0.075 0.47 葉酸㈣ 12 75.6 泛酸(mg) 0.45 2.83 維生素Β12(μ8) 0.3 1.89 生物素(pg) 2.2 13.9 -10- 145394.doc 201032734 膽鹼(mg) 10 63 肌醇(mg) 5.0 31.5 牛磺酸(mg) 7.0 44.1 肉驗(mg) 1.6 10.1 Fe(mg) 1.2 7.56 ι_ 15 94.5 Cu(mg) 0.07 0.44 δβ(μβ) 2.0 12.6 Zn(mg) 0.75 4.72 核苷酸 CMP(mg) 2.3 14.5 UMP(mg) 1.5 9.5 AMP(mg) 0.7 4.4 GMP(mg) 0.3 1.9 可將根據本發明營養組合物作為唯一營養源餵養出生4 至6個月之嬰兒,隨後在引入固體食物期間作爲混合膳食 的一部分,直到約12月大時完全斷奶為止。 實例2 此實例研究將含不同量LA及ALA之膳食餵養新生幼天竺 鼠對斷奶後幼畜之總脂肪質量發展之影響。天竺鼠嬰兒被 認為係研究用於預測人類嬰兒脂肪質量發展之良好動物模 型,因爲如同新生人類嬰兒,新生幼天竺鼠天生具有顯著 φ 量的體脂肪量,而新生幼鼠則太痩。 研究設計: 將新生雄性天竺鼠分為三組,每組20隻動物。對每組餵 養哺乳/斷乳膳食21天,其中44%能量由脂肪提供。不同膳 食均呈等熱量,且僅ALA含量不同。高含量ALA膳食含有 以總脂肪酸計之10% ALA,中等含量ALA膳食含有以總脂 肪酸計之2·4°/α ALA及低含量膳食含有以總脂肪酸計之 0.85% ALA。膳食之間之LA含量保持相對恒定,以使 LA:ALA之比例分別為約2、10及30。表1進一步詳細出示 145394.doc • 11 - 201032734 三種飲食之脂肪酸組成。 表1 :哺乳/斷乳膳食之脂肪酸組成: 佔總脂肪酸之% 10% ALA 2.4% ALA 0.8% ALA C12:0 7.1 8.2 7.9 C14:0 3.4 3.9 3.7 C16:0 22.7 22.0 21.8 C16:l 0.2 0.1 0.1 C18:0 3.0 3.2 3.0 C18:l 33.5 33.0 33.3 C18:2n-6(LA) 20.2 26.2 28.5 C18:3n-3(ALA) 9.9 2.4 0.8 C20:0 0.0 0.0 0.0 C20:l 0.0 0.0 0.0 C20:4n-6 0.0 0.0 0.0 C20:5n-3 0.0 0.0 0.0 C22:0 0.0 0.0 0.0 C22:5n-3 0.0 0.0 0.0 C22:6n-3 0.0 0.0 0.0 LA/ALA 2.0 10.7 33.6 哺乳/斷乳期(第21天)結束時,對所有組餵以含有2〇/〇 ALA及26%LA之具有中度高脂肪含量(35%能量來自脂肪) 的膳食至第136天。於第21、51、79、107、128及136天記 錄體重及脂肪質量,並於第21及130天記錄腹膜後的脂肪 組織細胞結構、血漿脂肪酸組成、及胰島素。 ◎ 結果: 如期望,哺乳/斷乳期結束(第21天)時,1〇% Ala組之血 漿磷脂(表2)及甘油三酸酯(表3)部份中的ALA濃度均比其 他組高。 表2.第21天之血漿磷脂中脂肪酸(gg/ml)組成。平均值士平 均標準誤差 145394.doc •12· 201032734 高含量ALA 中等含量ALA 低含量ALA C10:0 0.1 ±0.02 0.1 ±0.03 0.1 ±0.07 C12:0 0.2 ± 0.03 0.2 ± 0.02 0.3 ±0.13 C14:0 0.8 ± 0.23 1.0±0.10 1.1 ±0.17 C16:0 35.9 ±9.1 49.3 士 8.9 40.2 ±3.6 C17:0 1.2 ±0.38 1.9 ±0.41 1.2 ±0.10 C18:0 70.1 ±23.6 98.6 ±28.1 68.6 ±4.2 C18:l n-9順式+反式 23.4 ±7.6 30.8 ± 7.3 23.2 ±1.9 C18:l n-7順式+反式 3.1 ±0.8 6.2 ± 1.4 5.2 ±0.9 Cl 8:2 n-6(LA) 67.5 ± 22.2 99.0 ± 26.3 77.0 ±7.5 C18:3n-6(GLA) 0.1 ±0.06 0.1 士 0.09 0.2 ±0.13 C18:3n-3(ALA) 2.9 ±1.8 0.9 ± 0.2 0.6 ± 0.2 C20:0 1.2 ±0.5 1.5 ±0.2 0.9 ± 0.03 C20:ln-9 0.5 ± 0.2 0.7 士 0.08 0.6 ±0.1 C20:2n-6 0.8 ±0.1 1.2 ±0.1 1.3 ±0.2 C20:3n-6 0.9 ± 0.2 1.1 ± 0.25 1.0 ±0.07 C20:4n-6(AA) 11.4 ±3.6 14.8 ±3.0 11.7±1.1 C20:3n-3 0.3 ± 0.08 0.2 ± 0.06 0.1 ± 0.03 C22:0 1.9 ±0.9 2.1 ± 0.4 1.1 ±0.2 C22:ln-9 h 0.4 ±0.2 h0.4±0.1 1.5± 1.0 C20:5n-3(EPA) 0.2 ±0.1 0.1 士 0.03 0.1 ±0.03 C22:2n-6 1.1 ±0.5 1.5 ±0.2 0.8 ±0.1 C22:4n-6 1.2 ±0.5 1.8 ±0.3 1·2 ± 0.2 C24:0 2.6 ± 1.2 卜3.4士0_6 1.9 ±0.4 C24:ln-9 2.4 ±0.8 2.8 土 0·3 2.0 ±0.5 C22:5n-3(DPA) 2_1 ±0.8 1.7 士 0.3 0.9 ±0.1 C22:6n-3(DHA) 1.1 ±0.4 [1.3 ±0.3 0.7 ±0.1 ❹ 表3:第21天之血衆甘油三酸醋中FA(pg/ml)組成。平均值 ±平均標準誤差 高含量ALA 中等含量ALA 低含量ALA C10-.0 0.2 ±0.1 0.1 ± 0.04 0.2 ± 0.01 C12:0 0.9±0_2 1.0±0.1 0.8 ± 0.3 Cl 4:0 4.0 ± 1.1 4.6 ±0.7 4.0 ± 2.4 C16:0 49.1 ± 10.7 52.8 ±5.7 42.2 ±18 C17:0 0.9 ± 0.2 1.1 ±0.2 0.7 ± 0.09 C18:0 15.7 ±3.3 14.4 士 2.3 10.5 ±3.5 C18:l n-9順式 85.0 ± 17.8 85.4 ±6.0 63.2 ±18 C18:l n-7順式 2.6 ± 0.5 2.8 ± 0.3 2.0 ± 0.6 Cl 8:2 n-6(LA) 72.8± 13.7 85.4 ±6.0 71.1 ±27.9 145394.doc -13· 201032734 C18:3n-6(GLA) 0.2 ±0.2 0.6 ± 0.05 0.5 ±〇.l C18:3n-3(ALA) ll.l±2.5a 5.1 ±0.7B 2.7 ± 0.2 b C20:0 0.5 ± 0.2 0.7 ±0.1 0.2 ±0.1 C20:ln-9 1.2±0·1 1.3 ±0.1 LΠ ±0.5 C20:2n-6 1.4 ±0.2 1.5 ±0.2 1.6 ±0.8 C20:3n-6 6.8 ±0.1 0.7 ± 0.09 0.6 ±〇.〇9 C20:4n-6(AA) 3.7 ± 0.4 3.5 ± 0.3 3.7 ±0.3 C20:3n-3 0.4 ±0.1 0.2 ± 0.05 0.1 ±0.09 C22:0 0.4 ± 0.04 0.4 ±0.05 0.3 ± 0.02 C22:ln-9 0.3 ± 0.08 0.2 ± 0.02 0.2 ± 0.03 C20:5n-3(EPA) 0.3 ± 0.04 0.1 ±0.04 0.1 ± 0.08 C22:2n-6 ~~—~~ 0.3 ± 0.04 0.3 ± 0.06 0.2 ± 0.08 C22:4n-6 6.9 ±0.1 0.9 ±0.1 0.9 ± 0.2 C24:0 0.7 ±0.1 0.8 ±0.1 0.6 ±0.1 C22:5n-3(DPA) 0.8 ±0.1 0.6 ±0.1 0.4 ±0.01 C22:6n-3(DHA)~~ 0.3 ±0.1 0.3 ± 0.06 0.2 ± 0.05 不同字母表示在ρ<0·05下具有統計顯著性;ND,不可 檢測 如圖1所示’實驗期間三組之間的平均體重並無顯著不 同。然而’圖2顯示,第21天至第78天期間,高含量ALA 組所增加體重少於其他組。 哺乳/斷乳期(21天)結束時,由NMR測定各組間之總脂肪 質量並無差異。然而’高含量ALA組之腹膜後脂肪組織之 脂肪細胞直徑平均值小於其他組(表4)。 表4 :脂肪細胞直徑。平均值±平均標準誤差 ,组 細胞直徑(μιη) 高含量 ALA 27.5 ± 0.8 中等含量ALA 31.1 ±1.5 低含量 ALA 31.9 ±1.7 高含量ALA組的直徑較大(3〇至50 μιη)之脂肪細胞數量 較少(表5)。 145394.doc •14- 201032734 表5 ··第21天時,每克腹膜後脂肪組織中每段直徑範圍内 之總細胞數量(χ1〇6)。平均值±平均標準誤差 細胞直徑 10% ALA 2.4% ALA 0.8% ALA 15-19 1.27 ±0.2 1.19 ±0.2 0.91 ±0_2 19-29 3·82± 0_6 3·70±0·5 3.68 ±0.8 30-39 2.18 ±0·4 3_54±0·2 4.43 ± 0.8 40-49 0.37 ±0·1 1.47 ±0.2 1.85 ±0.7 50-60 0.07 ± 0.02 0.34 ± 0.04 0.49 ±0.3 ❹ 有趣的是’觀察到勝食中大脂肪細胞(>40 μιη)數量盘 ALA百分比之間存在劑量-效應關係。自圖3可知,攝入 ALA越多,大脂肪細胞的數量越少。 出乎意料地,如圖4及5中所示,在第79天(p<〇 〇1)、第 107天(ρ<〇·〇1)及第128天(ρ=〇·〇8)時,低含量ALA組比高含 量ALA組具有更高之脂肪質量值(以克及百分比表示)。 於第21天時,各組間血漿胰島素濃度並無差異。然而, 如圖6所示,實驗結束時,低含量ALA組之血漿胰島素濃 φ 度約為其他兩組的1.5倍。圖7顯示,在胰腺胰島素含量方 面觀察到相似結果。當與高含量ALA組比較時(p=0 08), 低含量ALA組之胰腺胰島素含量約增加14倍。 此實例明確證明,於嬰兒期餵以富含ALA之膳食對脂肪 組織之漸進發展或印記扮演重要角色,此方式可降低日"後 對過度發展的感$,)·生。具體而•,其#果顯示哺乳/斷乳 期攝取具有高LA:ALA比例之低含量ALA會導致日後肥胖 及罹患咼胰島素▲症之趨勢增強。 實例3 145394.doc 201032734 此實例利用D20方法研究將含有不同量LA及ALA之膳食 餵養新生幼天竺鼠時,對脂肪組織細胞(AT-細胞)之增殖率 及脂肪重新合成(DNL)的影響。研究實例2之高含量ALA組 及低含量ALA組。每組10隻幼畜接受5天D20,然後在第21 天時處死。其他10隻幼畜接受5天D20,然後在第136天時 處死。於第一曰清晨經腹腔投與氘化水(經減菌的0.9% NaCl、99% D20,依35 mg/g體重)。然後,其餘5天内使幼 畜隨意飲用氘化水(富含8%氘)。隨後於異氟烷麻醉下藉由 放血法處死。將來自主動脈之血液收集於肝素化小瓶中 (最少200 μΙ〇。收集腹膜後、附睾及皮下脂肪組織及肝臟 以及來自後肢之骨髓,並於分析前保存在-80°C下。 先前已詳細論述分析步驟(Neese RA、Siler SQ、Cesar D、Antelo F、Lee D、Misell L、Patel K、Tehrani S、 Shah P、Hellerstein MK,「Advances in the stable isotope mass spectrometric measurement of DNA synthesis and cell proliferation」Analy Biochem 2001; 298: 189-195) ° 簡而 言之,自脂肪組織(約50 mg)提取AT細胞之基因組DNA及 甘油三酸酯(TG)。藉由聯結氣相層析之質譜儀(GC/MS, Hewlett-Packard,Palo Alto,CA)來確定DNA中的氘富集量 及來自TG之棕櫚酸酯。 以D20併入量計算DNA複製(細胞增殖)及DNL之用法係 基於前體-產物關係(Hellerstein MK,Neese R.「Mass isotopomer data analysis: a technique for measuring biosynthesis and turnover of polymers j Am J Physiol 1992; 145394.doc -16· 201032734 263: E988-E1001)。於此方法中,藉由定量有標記之DNA 股之比例來計算標記期間所發生之細胞分裂次數。以脂肪 DNA中之EM1(同位素過量富集)除以(標準化)骨髓DNA中 之EM1,計算脂肪組織細胞之增殖速率分率(FSR細胞,以 新細胞%/5天計)。使用骨髓富集量估算每一隻動物可達到 之最大DNA富集量。 利用質量同位素分佈分析(MIDA),由來自水併入TG-棕 φ 櫚酸酯之標記氘計算TG中之DNL或「棕櫚酸酯合成速率分 率」(FSR棕櫚酸酯,以新棕櫚酸酯%/5天計)。基於所測定 的體内水份富集量,計算棕櫊酸酯中可達到之最大氘富集 量(計算方法詳述於Hellerstein MK及Neese RA之「Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations」 Am J Physiol 1999; 276: E1146-E1170 中)。 結果 〇 脂肪組織及肝臟重量概述於表6中。 表6 :第21及第136天之脂肪組織(AT)及肝臟重量(以g計)。 組 肝臟 附睾AT* 腹膜後AT 第21天 高含量ALA 8.57 ±0.54 0.15 ±0.02 0.56 ±0.14 低含量ALA 7.09 ± 0.40 0.09 ±0.01 0.38 ± 0.06 第136天 高含量ALA 29.73 ±2.15 8.09 ± 1.55 3 9.36 ± 1.21 低含量ALA 30.10± 1.11 10.94 ± 0.58 b 10.98 ±0.54 不同字母表示在P<〇.05下具有統計顯著性。 145394.doc 17 201032734 *第136天時,高/低含量Ala組之間P=〇.020 表7中概述早期膳食處理對脂肪堆積物中細胞合成速率 分率(FSR或增殖速率分率)之影響^ AT-細胞包括諸如全部 脂肪組織的脂肪細胞及基質血管細胞(前-脂肪細胞、腸上 皮細胞、巨噬細胞等)之所有類型細胞。 表7:第21及第136天之FSR(以新細胞%/5天計) 組 皮下AT* 附睾AT 腹膜後AT 第21天 高含量ALA 8.9 ±8.7 13.5 ±2.0 5.3 ± 2.3 低含量ALA 18.7 ± 13.7 15.0 ±4.1 3.3 ± 0.7 第136天 高含量ALA 8.6 ± 1.7* 7.7 ± 1.3 4.0 ± 0.6 低含量ALA 15.2 ± 1.3b 7.8 ±2.6 7.9 ±2.3 不同字母表示在P<0.05下具有統計顯著性 * :第136天時,高/低含量ALA組之間P=0.021 此等結果顯示’與高含量ALA組比較,低含量ALA組 中’第136天時(Ρ=〇·〇21)皮下脂肪組織之細胞增殖速率較 高(雙倍)及腹膜後細胞增殖較快(但不明顯),但附睾脂肪 組織之細胞增殖未變化。因皮下脂肪組織係成年天竺鼠全 身之主要脂肪堆積物,故於此脂肪組織中細胞增殖加快可 解釋攝取低含量ALA後所觀察到的脂肪質量組合物增加 (於實例2中獲得的結果)的原因。在機轉上,該等結果顯示 低含量ALA組中之體脂肪質量增加與成年後期天竺鼠中脂 肪組織細胞增殖速率(過度增生)提高有關。 攝取低含量ALA不會改變脂肪堆積物中之脂肪重新合成 145394.doc • 18 - 201032734 (DNL·),但於第21日,發現低含量ALA組之肝臟DNL·高於 高含量ALA 組(P<0.001)(表 8)。 表8:第21及第U6日之DNL(以新棕櫚酸酯%/5天計) 組 肝臟 皮下AT 附睾AT 腹膜後AT 第21曰 高含量ALA 8.8±2.6a 9.3 ±6.6 14.9 ±2.8 13.8 ±5.4 低含量ALA 17.4 士 3.7b 2.2 ± 1.8 17.1 ±2.5 12.9 ±2.3 第136日 高含量ALA 5.7 ± 0.6 1.87 ±0.26 1.18 ±0.16 1.40 ±0.39 低含量ALA 5.6 ± 0.4 1.29 ±0.18 0.92 ±0.12 1.06 ±0.07 不同子母表不在P<0.001下之統計顯著性。 此實例3顯示,於哺乳/斷乳期攝取低含量ALA會提高出 生21天的天竺鼠之肝臟DNL之速率,及提高成年天竺鼠之 皮下脂肪組織之細胞增殖速率。 【圖式簡單說明】 圖1顯示餵以不同膳食的三組幼天竺鼠於出生頭136天内 φ 之體重變化; 圖2顯示三組幼畜在第21天與第79天期間所增加的體重 中位值; 圖3顯示與ALA攝取量成函數關係之巨大脂肪細胞的數 量圖; 圖4顯示第21天至第128天期間三組脂肪質量之變化(以 克計); 圖5顯示三組於第79天、第i〇7天及第128天之脂肪質量 變化(以佔總體重之百分比表示); 145394.doc •19- 201032734 圖6顯示三組於第136天之平均血漿胰島素濃度;及 圖7顯示三組於第136天之胰腺胰島素含量。 145394.doc 20·
Claims (1)
- 201032734 七、申請專利範圍: 1. 一種營養組合物,其包含一種蛋白質源、一種脂質源及 一種碳水化合物源,其中以佔總脂肪酸含量之百分比表 示,該脂質源分別包含至少i 6重量%亞油酸及至少2重量 % α-亞麻酸,且其含量可使亞油酸:心亞麻酸之比例介 於1至10之間。 2. 3. 如凊求項1之營養組合物,其中該亞油酸含量係總脂肪 酸之18至300/〇。 如明求項1或2之營養組合物,其中該亞油酸含量係總脂 肪酸之18至25%。 4.如叫求項1或2之營養組合物,其中該…亞麻酸含量係總 脂肪酸之2至12%,更佳係6至11%。 5·如請求項1或2之營養組合物,其中該α-亞麻酸含量係總 脂肪酸之6至11 %。 6. 如明求項1或2之營養組合物,其中亞油酸:α亞麻酸之 參 比例較佳係介於2與6之間。 7. 一種以亞油酸及α-亞麻酸於製造如請求項丨至6中任一項 之營養組合物上之用途,供投與出生6個月内之嬰兒, 從而降低日後罹患肥胖症風險。 8. —種以如請求項丨至6中任一項之組合物於製造用於嬰兒 之營養組合物從而降低日後罹患肥胖症或超重之風險上 之用途’該組合物係計畫投與出生頭幾個月的嬰兒。 9. 如吻求項7或8之用途,其中該嬰兒係幼嬰寵物如狗或 書苗0 145394.doc 201032734 10如凊求項7之用途,其中該降低日後罹患肥胖症之風險 之特徵在於與未接受該組合物之對照群體比較,脂肪質 量在統計上顯著下降。 11 ·如請求項7之用途,其中該降低曰後罹患肥胖症之風險 之特徵在於此等風險在人類嬰兒之肥胖反彈年齡(如5歲 後)時明顯降低。 145394.doc
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09150858 | 2009-01-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
TW201032734A true TW201032734A (en) | 2010-09-16 |
Family
ID=40636107
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW098146464A TW201032734A (en) | 2009-01-19 | 2009-12-31 | Nutritional composition for infants |
Country Status (15)
Country | Link |
---|---|
US (2) | US8586077B2 (zh) |
EP (1) | EP2387331B8 (zh) |
CN (1) | CN102271534B (zh) |
AU (1) | AU2009337747B2 (zh) |
BR (1) | BRPI0924051A2 (zh) |
CA (1) | CA2749254A1 (zh) |
CL (1) | CL2011001734A1 (zh) |
ES (1) | ES2663195T3 (zh) |
MX (2) | MX2011007222A (zh) |
MY (1) | MY159390A (zh) |
RU (1) | RU2540538C2 (zh) |
SG (1) | SG172774A1 (zh) |
TW (1) | TW201032734A (zh) |
WO (1) | WO2010081604A1 (zh) |
ZA (1) | ZA201106084B (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2749254A1 (en) | 2009-01-19 | 2010-07-22 | Catherine Mace | Nutritional composition for infants |
EP2514435A1 (en) * | 2011-04-19 | 2012-10-24 | Nestec S.A. | Infant formula for use in the prevention of cardiovascular diseases |
EP3366143A1 (en) | 2011-06-20 | 2018-08-29 | H.J. Heinz Company Brands LLC | Probiotic compositions and methods |
EP3079770B1 (en) * | 2013-12-12 | 2020-05-13 | Société des Produits Nestlé S.A. | Synthetic milk compositions for infants less than three months old and for infants and children more than three months for ensuring optimal growth and preventing obesity |
EP3079501B1 (en) * | 2013-12-12 | 2019-08-14 | Société des Produits Nestlé S.A. | Synthetic nutritional compositions especially adapted for male and female infants and young children |
RU2678418C1 (ru) * | 2013-12-12 | 2019-01-28 | Нестек С.А. | Искусственные молочные композиции для оптимального роста, развития и профилактики ожирения у младенцев и детей младшего возраста мужского и женского пола |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0880902A1 (fr) | 1997-05-27 | 1998-12-02 | Nestlé Produkte AG | Procédé de traitement d'une matiére première lactosérique |
US6495599B2 (en) * | 2000-04-13 | 2002-12-17 | Abbott Laboratories | Infant formulas containing long-chain polyunsaturated fatty acids and uses therof |
EP1634599A1 (en) * | 2004-08-20 | 2006-03-15 | N.V. Nutricia | Iimmune stimulatory infant nutrition |
WO2006052134A2 (en) * | 2004-11-12 | 2006-05-18 | N.V. Nutricia | Food composition comprising a protein- and a lipid fraction for rapidly attenuating inflammatory responses |
EP1811865B1 (en) * | 2004-11-26 | 2008-07-16 | N.V. Nutricia | Infant nutrition with protease inhibitor |
PT1898724E (pt) | 2005-07-01 | 2010-11-26 | Nutricia Nv | Nutrição infantil com proteínas hidrolisadas |
WO2008054192A1 (en) | 2006-11-02 | 2008-05-08 | N.V. Nutricia | Use of nutritional compositions for preventing disorders |
EP1962617A2 (en) * | 2005-12-23 | 2008-09-03 | N.V. Nutricia | Infant nutritional compositions for preventing obesity |
EP1932437A1 (en) * | 2006-12-15 | 2008-06-18 | Nestec S.A. | Infant formula |
CA2749254A1 (en) | 2009-01-19 | 2010-07-22 | Catherine Mace | Nutritional composition for infants |
-
2009
- 2009-12-16 CA CA2749254A patent/CA2749254A1/en not_active Abandoned
- 2009-12-16 ES ES09796696.4T patent/ES2663195T3/es active Active
- 2009-12-16 MX MX2011007222A patent/MX2011007222A/es active IP Right Grant
- 2009-12-16 WO PCT/EP2009/067297 patent/WO2010081604A1/en active Application Filing
- 2009-12-16 EP EP09796696.4A patent/EP2387331B8/en active Active
- 2009-12-16 BR BRPI0924051-9A patent/BRPI0924051A2/pt active Search and Examination
- 2009-12-16 MY MYPI2011002882A patent/MY159390A/en unknown
- 2009-12-16 CN CN200980154101.1A patent/CN102271534B/zh active Active
- 2009-12-16 MX MX2014010037A patent/MX357863B/es unknown
- 2009-12-16 SG SG2011045382A patent/SG172774A1/en unknown
- 2009-12-16 AU AU2009337747A patent/AU2009337747B2/en active Active
- 2009-12-16 RU RU2011134675/13A patent/RU2540538C2/ru active
- 2009-12-16 US US13/145,042 patent/US8586077B2/en active Active
- 2009-12-31 TW TW098146464A patent/TW201032734A/zh unknown
-
2011
- 2011-07-15 CL CL2011001734A patent/CL2011001734A1/es unknown
- 2011-08-18 ZA ZA2011/06084A patent/ZA201106084B/en unknown
-
2013
- 2013-03-06 US US13/787,170 patent/US8999926B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
MX2011007222A (es) | 2011-08-08 |
EP2387331B8 (en) | 2018-11-28 |
US20130177667A1 (en) | 2013-07-11 |
US8586077B2 (en) | 2013-11-19 |
AU2009337747A1 (en) | 2011-07-21 |
BRPI0924051A2 (pt) | 2015-07-21 |
RU2540538C2 (ru) | 2015-02-10 |
EP2387331A1 (en) | 2011-11-23 |
MY159390A (en) | 2016-12-30 |
MX357863B (es) | 2018-07-26 |
ZA201106084B (en) | 2016-07-27 |
US20120004163A1 (en) | 2012-01-05 |
CA2749254A1 (en) | 2010-07-22 |
EP2387331B1 (en) | 2018-02-07 |
AU2009337747B2 (en) | 2014-01-09 |
CN102271534B (zh) | 2014-07-09 |
US8999926B2 (en) | 2015-04-07 |
CL2011001734A1 (es) | 2012-02-10 |
WO2010081604A1 (en) | 2010-07-22 |
CN102271534A (zh) | 2011-12-07 |
RU2011134675A (ru) | 2013-02-27 |
SG172774A1 (en) | 2011-08-29 |
ES2663195T3 (es) | 2018-04-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2455857C2 (ru) | Питательная композиция | |
EP2413718B1 (en) | Use of arachidonic acid for the reduction of the risk of insulin resistance later in life | |
AU2009306497B2 (en) | Nutritional composition with anti-regurgitation properties | |
SE536599C2 (sv) | Näringssammansättning med lågt kalori- och lågt proteininnehåll | |
US8999926B2 (en) | Nutritional composition for infants | |
EP3073844B1 (en) | Age-tailored nutritional compositions with a varying protein content | |
JPH10262607A (ja) | 乳幼児用栄養組成物 | |
WO2016097221A1 (en) | Infant nutrition with hydrolysed protein and palmitic acid | |
JP4307475B2 (ja) | 乳幼児用栄養組成物 | |
Kasemsup | Premature Formula: Update |