TW201029675A - Liquid cosmetic - Google Patents

Abstract

Disclosed is a white turbid liquid cosmetic which has excellent long-term stability, can contain a (semi)solid oily component stably to exhibit a moist feeling upon application to the skin, and can be produced conveniently. Specifically disclosed is a liquid cosmetic comprising (1) 0.01 to 5% by mass of a POE-POP copolymer dialkyl ether, (2) 0.01 to 1.0% by mass of a hydrophilic surfactant selected from POE(30) phytosterol, POE octyl dodecyl ether, POE-POP decyl tetradecyl ether and POE hydrogenated castor oil, (3) 0.001 to 0.5% by mass of a lipophilic surfactant selected from sorbitan sesquioleate, sorbitan sesquiisostearate, sorbitan sesquistearate, sorbitan trioleate, polyoxyethylene (C12-15)alkyl ether phosphate (2E.O.) and polyglyceryl-2 diisostearate, and (4) 0.01 to 2% by mass of an oily component, wherein isostearic acid makes up 20% by mass or more of the oily component.

Description

201029675 VI. Description of the Invention: [Technical Field] The present invention relates to a liquid cosmetic, and more particularly to a liquid cosmetic such as a white turbid, refreshing lotion. [Prior Art] In recent years, the appearance of a white turbid cosmetic with fine particles of oil gives the skin an excellent touch, and it can achieve a wide range of touch and skin improvement effects in accordance with the user's preference. Consumers love it, not only for skin care products, but also for body care products. For example, in the patent document, a translucent-transparent chemical chain water-like cosmetic can be obtained by using isostearic acid and a hydrophilic surfactant. However, this light-weight material has a tendency that when the oil content is increased, the active dose is also increased due to the stickiness, so that good usability cannot be obtained. Further, Patent Document 2 discloses a white turbid cosmetic which is a combination of a hydrophilic nonionic active agent and a lipophilic nonionic active agent, and which is formulated with an isostearic acid as an essential component. However, the white turbid cosmetic has the following disadvantages: It is necessary to adjust the emulsification temperature to a low temperature during mass production, so that it is difficult to prepare a semi-solid oil or a solid oil. Further, Patent Document 3 discloses an oil-in-water type ultrafine emulsion composition using a polyoxyethylene polyoxypropylene copolymer dialkyl ether. However, the ultrafine emulsion composition has the disadvantage that it is difficult to blend solid oil and semi-solid = oil. Thus, in the prior art, if the solid or semi-solid oil component is adjusted to improve the usability such as wettability, the stability of the system may be impaired, or the problem of the manufacturing step may be caused. It is difficult to formulate solid oil or semi-solid oil. [PATENT DOCUMENT] [Patent Document 1] Japanese Patent Laid-Open No. Hei. No. 2001-270667 (Patent Document 2) Japanese Patent Laid-Open Publication No. 2005-255667 (Patent Document 3) Japanese Patent Laid-Open No. 2007-15972 SUMMARY OF THE INVENTION [Problem to be Solved by the Invention] The present invention has been made in order to cope with the prior art as described above, and an object thereof is to provide an excellent long-term stability, which can be stably formulated by a solid form. The oily component imparts a touch and emollient effect to moisturization, and can be easily manufactured into a white turbid liquid cosmetic. [Technical means for solving the problem] The present invention is a liquid cosmetic comprising the following components (1) to (4). (1) Polyoxyethylene. Polyoxypropylene copolymer Dialkyl ether 001~5质量% (2) Selected from polyoxyethylene (3〇) phytol, polyoxyethylene octyl ^__ And the hydrophilic interface activity in the polyoxyethylene hardened E sesame oil. 〇1~1.〇% by mass (3) selected from sorbitan sesquitone (4), sorbitan sesquitained vinegar, sorbitan sesquisulfate I mountain (four) rape three oil (four), the poly- 酉曰 亲 lipophilic active agent 〇〇〇 1 ~ 〇 5 mass% 144584.doc 201029675 (4) all oil contains 2% by mass or more of isostearic acid The fraction is 0.01 to 2% by mass. By the present invention, a part or all of the diol is partially or completely substituted with a polyoxyethylene polyoxypropylene copolymer dialkyl ether in the case where a glycol is previously used for dissolving the oil, whereby the surfactant is turbid The point is improved. Thereby, the high temperature of the manufacturing step can be achieved, so that the solid oil or the semi-solid oil can be adjusted. , φ, polyoxyethylene. The polyoxypropylene copolymer dialkyl ether functions as a coagent, thereby eliminating the need for higher shear forces and simplifying the manufacturing steps. [Effects of the Invention] According to the present invention, it is possible to produce a white turbidity which is excellent in long-term stability and which can be used to stably apply a solid/semi-solid oil component to impart moisture and emollient effects, and which can be easily manufactured. Liquid cosmetic. [Embodiment] Hereinafter, preferred embodiments of the present invention will be described. • 0) Polyoxyethylene/polyoxypropylene copolymer dialkyl ether as the polyoxyethylene. Polyoxypropylene copolymer dialkyl ether used in the present invention can be exemplified by polyoxypropylene/polyoxyethylene copolymerization. Dimethyl ether, polyoxypropylene polyoxyethylene copolymer dinuclear test, particularly good is a random type. Further, 'polyoxypropylene. Polyoxyethylene random copolymer dialkyl ether can be produced by a public method. For example, it can be obtained by subjecting a compound having a fluorine group to addition polymerization of ethylene oxide and propylene oxide, and then adding the addition poly-α product and the alkyl dentate in the presence of a basic catalyst. Ether reaction. The average addition mole number of oxypropylene is 1~Μ, the average addition of oxyethylene chain is 144584.doc 201029675 The molar number is 9~100, the average addition molar number of oxyethylene is relative to oxyethylene and oxypropylene. The ratio of the average of the lean average addition moles [POE (polyoxyethylene) / (POE + POP (polyoxypropylene))] is preferably 0.5 to 0.9. Here, ΡΟΕ means polyoxyethylene, and POP means polyoxypropylene. The blending amount of the polyoxyethylene/polyoxypropylene copolymer dialkyl ether is 0.01 to 5% by mass, preferably 0.3 to 3% by mass based on the total amount of the liquid cosmetic. When the polyoxyethylene/polyoxypropylene copolymer dialkyl ether is too small or too large, particles are increased and the stability tends to be deteriorated. (2) Hydrophilic surfactant The hydrophilic surfactant used in the present invention is selected from the group consisting of polyoxyethylene (30) phytosterol, polyoxyethylene octyl lauryl ether and polyoxyethylene hardened castor oil. The middle. When a hydrophilic surfactant other than the above components is used, the oil component cannot be stably formulated, and separation occurs at a high temperature. Among the components (2), polyoxyethylene (30) phytosterol is particularly preferred. As a commercial item of the polyoxyethylene (30) phytosterol, NIKKOL BPS-30 (manufactured by Nikko Chemicals Co., Ltd., trade name) can be mentioned. As a commercial item of the polyoxyethylene octyl lauryl ether, Emalex OD-30 (manufactured by Nihon Emulsion Co., Ltd., trade name) and SEODOL E-2020 (trade name, manufactured by Nihon Emulsion Co., Ltd.) can be mentioned. As a commercial item of the polyoxyethylene hardened castor oil, NIKKOL HCO-60 (manufactured by Nikko Chemicals Co., Ltd., trade name) is mentioned. The compounding amount of the component (2) in the liquid cosmetic of the present invention is 0.01 to 1.0% by mass, preferably 0.04 to 0.1% by mass. When it is less than 0.01% by mass, a stable white turbid cosmetic material cannot be obtained and separation occurs. If it exceeds 1.0% by mass, it will produce 144584.doc 201029675. (3) lipophilic surfactant The lipophilic surfactant used in the present invention is selected from the group consisting of sorbitan sesquioleic acid vinegar, sorbitan sesquiisostearate, sorbitan sesquistearate Ester, sorbitan trioleate, polyoxyethylene alkyl (carbon number 12 to 15) ether phosphorus 'ester (2 Ε. 〇 ·) and polyglycerol 2 diisostearate. When a lipophilic surfactant other than the above components is used, a stable white turbid cosmetic cannot be obtained. ❹ As a commercial product of sorbet sesame oleic acid vinegar, NOFABLE SO-852S (manufactured by NOF Corporation, trade name); sorbitol hepatic sesquiisosulphate, ESTEMOL 182V (Nisshin OilliO shares) (manufactured by the company, trade name); as sorbitan sesquistearate, NIKKOL SS-l5 (manufactured by Nikko Chemicals Co., Ltd., trade name); and sorbitol trioleate, exemplified by VIII 61^ s〇853S (manufactured by Nippon Oil Co., Ltd., trade name), as a polyoxyethylene alkyl (C12~C15) ether saponin (2Ε.〇·) 'DDP-2 (manufactured by Nikko Chemicals Co., Ltd., In the case of polyglycerol-2 diisostearate, w〇GEL_i 8DV (manufactured by Matsumoto Trading Co., Ltd., trade name) is mentioned. The compounding amount of the lipophilic surfactant in the liquid cosmetic of the present invention is 0.001 to 0.5% by mass in total, preferably 〇3 to 〇3% by mass. When the pressure is less than 0.0 01, it is not possible to stably mix the oil. Even if it exceeds 〇 5 mass%, stable white turbidity cannot be obtained: the rough material. (4) Oil In the present invention, isostearic acid is used as an essential component. Adjustment of isostearic acid 144584.doc 201029675 The dosage is divided into 20% by mass or more based on the total oil, and only isostearic acid can be used as the oil component. The blending amount of isostearic acid is preferably from 30 to 50% by mass based on the total of the oil. Separation occurs when the amount of isostearic acid is less than (9) the mass of the oil. Further, the other oil component used in the liquid cosmetic of the present invention is not particularly limited as long as it can be blended into a cosmetic, and may be a synthetic or a solid or a solid. For example, avocado oil, camellia oil, sea turtle oil, macadamia nut oil, corn oil, oyster sauce, eucalyptus oil, rapeseed oil, egg butter, sesame oil, almond oil, wheat germ oil, camellia oil, and sesame oil, Linseed oil, safflower oil, cottonseed oil, sage oil, soybean oil, peanut oil, tea oil, hazelnut oil, rice bran oil, Chinese tung oil, simmered tung oil, jojoba oil, germ oil triisocaprylate, Triisopalmitate, octyl palmitate, isopropyl isostearate, isostearyl isostearate, isohexadecyl isostearate, hexyl isostearate, iso Tetradecyl stearate, isohexadecyl octanoate, cetyl isooctanoate, isostearyl octanoate, isophthalic acid isodecanoic acid, octyl dodecyl dimethyl octanoate Ester, oleyl myristate, isostearyl succinate, isohexadecyl stearate, octyl stearate, isostearyl palmitate, isohexadecyl palmitate Ester, octyl palmitate, isostearyl octanoate, isohexadecyl myristate, octyl 10 Dialkyl ester, decyl myristate, isopropyl palmitate, isopropyl myristate, trimethylolpropane triisostearate, neopentyl glycol dicaprate, dioctyl sebacate , 12-stearyl oxyalkyl stearate, octyl dodecyl stearyl, dioctyl adipate, malic acid 144584.doc -8 - 201029675 Diisostearyl ester, octyl methoxycinnamate, octyl lauryl lactate, isostearyl lactate, octyl p-dimethylaminobenzoate, liquid paraffin, squalane, Isoalkane, α-olefin condensate, polybutene, volatility, Wei 7 oxygen, volatile dimethyl polyoxide, methyl phenyl polyoxo, oleyl alcohol, 2-octyl twelve Liquid fats such as alkanol; cocoa butter, coconut oil, . horse fat, hardened coconut oil, palm oil, tallow, sheep fat, hardened tallow, palm kernel oil, lard, beef bone fat, wood wax nuclear oil, hardened oil , beef fat, wood wax, hardened sesame oil, beeswax, candelabra wax, cotton wax, carnauba wax, laurel seedlings, Chinese sarcophagus, sorghum, brown coal, butterfly Fat, kapok, acetic acid lanolin, liquid lanolin, licorice, lanolin fatty acid isopropyl ester, lauric acid vinegar, reduced lanolin, lotus enamel, hard lanolin, shellac bad, cholesterol, plant Solid oils and waxes such as sterol, microcrystalline bismuth, mountain (tetra), stearyl alcohol, cetyl alcohol, camellic acid, stearic acid, meat and vegetable acid. These may be used alone or in combination of two or more. Among the oil components, as the liquid oil component, oils such as U-fired, dilute soot S-polymer, liquid stone soil, hydrogenated polyisobutylene, hetero-xenon-burning, isostearyl fermentation, etc. are preferred; Oil public, better 疋 疋 士 、, 崔 崔 澳洲 澳洲 澳洲 澳洲 澳洲 澳洲 澳洲 澳洲 澳洲 澳洲 澳洲 澳洲 澳洲 澳洲 ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; - In the present invention, by using the above-mentioned other oil component in combination with isostearic acid, it is possible to use a liquid cosmetic which is excellent in stability and which is excellent in touch. In the liquid cosmetic of the present month, in order to improve the wettability and the like, it is preferred to use the oil component of the component (4) in an amount of from 1 to 80% by mass based on the total oil. /. More preferably, it is a solid oil of 1 〇 to 8 〇 mass% and / 144584.doc 201029675 or a semi-solid oil. ▲; In the liquid cosmetic of the present invention, the ratio (mass ratio) of the above (7) component and (3) component to the component (4) (i.e., all oil components) is preferably () (4) ~ 1〇· 1~i : 1〇, more preferably (7)+(7):(4)= Bu 1:5. Within this range, stable liquidification (4) can be achieved. Further, the oily component of the liquid cosmetic of the present invention may be formulated into an oil-soluble drug and/or a fragrance to enhance the effect as a cosmetic by infiltrating the drug into the skin, or to impart an aromatic psychological effect to the use of the fragrance. Examples of the oil >capacitive agent include: retinol, retinyl acetate, retinyl palmitate, riboflavin butyrate, pyridoxine dicaprylate, pyridoxine dipalmitate , pyridoxine dilaurate, ascorbyl dipalmitate, ergot calciferol, cholecalciferol, tocopherol, tocopheryl acetate, methyl 'naphthoquinone, benzyl nicotinic acid, three gas symmetry Diphenylurea, trichlorohydroxydiphenyl ether, stearyl glycyrrhizinate, γ-oryzanol, dibutylhydroxytoluene, and the like. The liquid cosmetic of the present invention contains 1 to 2% by mass, preferably 0.1 to 1% by mass, of the oil containing isostearic acid. When the content is less than 0.01% by mass, the white turbidity is low (the L value is high)' if it exceeds 1 mass. /〇, it is difficult to obtain a stable white turbid lotion. Also, the oil contains 20 mass. /. The above isostearic acid. It is also possible to set all the oils to isostearic acid. When the isostearic acid is less than 20% by mass, it becomes unstable. In the liquid cosmetic of the present invention, in addition to the above-mentioned components, the components generally used in cosmetics, such as propylene glycol and dipropylene, can be suitably blended in such a range as not to impair the effects of the present invention. Yeast, 込3-butanediol, 1,4· 144584.doc •10- 201029675 Butanediol, diethylene glycol, triethylene glycol, diols such as polyethylene glycol having a molecular weight above 3%; glycerin Polyglycerols with molecular weights of diglycerin, hydrazine, and hydrazine; sorbitol, mannitol, wheat glutinous rice, sugar alcohols such as maltose, xylitol, erythritol; fructose, glucose , galactose, sucrose, sugar, maltose, lactose, trehalose and other sugars, talc, rfj ridge, mica, - prepared children & mother-in-law, cerium oxide, zeolite and other inorganic powder; (Nylon powder), polyethylene powder, polymethyl methacrylate methyl vinegar powder, poly berry powder, styrene and propylene glycol copolymer resin powder, cellulose powder and other organic powder; _ negative 彳卜# ^ Φ water titanium oxide, oxidation word and other inorganic white pigment; iron oxide (iron) calculation Nen 4 A, ) Inorganic red pigments; yellow iron oxide, loess and other inorganic yellow pigments; Λ ^ black iron oxide, carbon black and other black pigments; oxidized collateral, wind oxidized Ming ·, 〗 〖 Hk ik. * Ji Inorganic green pigments such as cobalt and cinnabar; inorganic blue pigments such as ultramarine and citrus; -g | #裔& Frequent leaves, titanium oxide coated mica, pigmented titanium dioxide coated mica, oxygenated silk Pearl pigments such as fish scales; metal powder pigments such as powder and copper powder; red 2〇1, red 2〇2, red 2〇4, red 205, red 220, red 226, red coffee , red 4〇5#, orange 203, dial color 2〇4, yellow 2〇5, yellow 4〇ι, and blue 404 organic pigment; red 3, red 1〇4, red Ι〇6, red 227, red 230, red 4〇1 'Red 505, 205, yellow 4, yellow 5, yellow 202, yellow 203, green 3 and blue Organic pigments such as No. 1 and the like '钡 or |g lake; chlorophyll, Buhuluo and other natural pigments; gum arabic, yellow Bismuth, galactan, guar gum, locust bean gum, karaya gum, gellan gum, carrageenan and other plant systems; three sacral gum, dextran, amber sulphate, pululolan and other microbial systems With the knife, collagen, casein 'albumin, gelatin and other animal lines 144584.doc 201029675 still molecular, starch-based polymer such as carboxymethyl starch, mercaptohydroxypropyl starch; thiol cellulose, ethyl cellulose, Cellulose polymers such as methyl hydroxypropyl cellulose, hydroxyethyl cellulose, sodium cellulose sulfate, hydroxypropyl cellulose, sodium carboxymethyl cellulose, crystalline cellulose; sodium alginate, propylene glycol alginate Alkyd-based polymer; I-ethyl alcohol, polyethylene acetate, polyethylene methyl ether, polyvinylpyrrolidone, vinyl pyrrolidone and vinyl acetate copolymer, carboxyvinyl polymer, etc. Polymer; sodium polyacrylate, polyethyl acrylate, polyalkanolamine, alkyl methacrylate and methacryl i monomethylaminoethyl copolymer, poly 2 propylene phthalamide 2 曱 曱Propane sulfonic acid Acrylic high-grade; magnesium ascorbyl phosphate, ascorbyl glucoside, vitamin B6 hydrochloride, panthenol ethyl ether and other vitamins; ultraviolet absorber, chelating agent, bactericide, anti-inflammatory agent, preservative 'plant extract, amine A reagent such as a base acid or a cooling agent; a lower alcohol such as ethanol or isopropanol; arbutin, a tranexamic acid, a guanamine or a salt thereof; a salicylic acid, an alkoxy salicylic acid or a salt thereof; A moisturizing agent such as a water-based agent such as 〇ethylascorbic acid or a salt thereof or a polyoxyethylene polyoxypropylene dimethyl ether random copolymer. The liquid cosmetic of the present invention can be produced by adding the above-mentioned surfactant to the aqueous phase which is stirred and dissolved while stirring the layer of the surfactant which is dissolved by heating and oil. The average particle diameter of the dispersed droplets of the oil component of the liquid cosmetic of the present invention is preferably from 50 to 300 nm. The liquid cosmetic of the present invention is preferably a cosmetic having a white turbidity of 丨~8〇. Here, the L value is a standard indicating the degree of turbidity, which is based on spectroscopic

Photometer (GRETAGMACBETH GE-700A: GRETAGMACBETH 144584.doc •12· 201029675 a system k), 5 ml of purified water is placed in the glass tank, and the light is transmitted through the moon. It is also 100' and the transparency when the light is completely blocked and the light is not transmitted is set to the value at the time of measurement. The liquid cosmetic of the present invention can be used as a sunscreen main ingredient, a sun oil main ingredient, and a cleaning main ingredient, in addition to a makeup water, a fragrance, and an emulsion for the purpose of skin care. Among them, a particularly good lotion is a cosmetic lotion. [Embodiment] Next, an embodiment of the present invention will be described. Prior to the description of the embodiments, the evaluation methods and their benchmarks performed in the present embodiment will be explained. (Stability) (1) Average particle diameter The average particle diameter of the emulsified droplets was measured using an ALV-5000/EPP Multiple Tau Digital Correlator (manufactured by Marumoto Co., Ltd.) for the prepared lotion. (2) Oscillation stability With regard to the stability after vibration or oscillation during transportation and use, a 100 mL glass container filled with half of the sample is placed on the oscillator of Jingrongtang Co., Ltd., and the ratio is 300 times per minute. The average particle diameter after shaking at a distance of 4 cm in 20 minutes was measured and evaluated. ◎: The average particle diameter is 150 nm or less. 〇: The average particle size exceeds 150 nm and is less than 300 nm. △: The average particle diameter exceeds 300 nm and is 1 〇〇〇 nm or less. X : The average particle size exceeds 1 〇〇〇 nm. 144584.doc -13- 201029675 (3) Long-term stability The test article was stored at 0 C and 50 ° C for 3 months, and the long-term stability was evaluated according to the following criteria. ◎: Separation, emulsification, change in average particle diameter, and the like were not confirmed at all. 〇: A slight emulsification, separation, or change in the average particle system was confirmed, and precipitation of isostearic acid or the like was not confirmed. △. A slight change in emulsification, separation, and average particle diameter was confirmed, and precipitation of isostearic acid or the like was confirmed. X. Separation, emulsification, change in average particle diameter, and precipitation of isostearic acid were confirmed. (Useability) The evaluation of the usability of the white turbid cosmetic of the present invention was carried out by two female functional inspectors, and was evaluated as a use test according to the following criteria. ◎: It was evaluated that the number of the functional inspectors of the white turbid cosmetic of the present invention was 16 or more. 〇: The functional inspectors who fully felt that the white turbid cosmetic of the present invention was 10 to 15 were evaluated. △: It was evaluated that the functional inspectors of the white turbid cosmetic of the present invention were 6 to 9 in total. X··Evaluation is that the number of the functional inspectors of the white turbid cosmetic of the present invention is 5 or less. Examples 1 to 18 and Comparative Examples 1 to 5 Using the formulations described in the following Tables 1 to 4, a liquid cosmetic was produced by the following method, and the properties were evaluated by the above method. The results are recorded together in I44584.doc -14- 201029675 in Tables 1 to 4. Further, (manufacturing method) describes the result of measuring the L value. The solvent containing the heat-dissolved interfacial active sputum, the oil component, and the polyoxypropylene copolymer dialkyl ether was uniformly mixed and stirred into the aqueous phase, thereby obtaining a white turbid lotion.

144584.doc 15- 201029675 [Table i]

144584.doc -16« 201029675 [Table 2]

Substance Name Example 7 Example 8 Example 9 Example 10 Example 11 Example 12 Residual amount of water Residual amount Remaining amount Remaining amount Remaining amount Residual amount Polyoxyethylene (17)·Polyoxypropylene (04) copolymer Dimethyl Ether 0.3 1 - - 3 0.3 Polyoxyethylene (14) • Polyoxypropylene (07) Copolymer Dimethyl ether - 0.1 5 - 1,3-1,3-butanediol 0.1 - 3 0.1 1 0.1 Squalane - one _ - - _ Olefin oligomer 0.2 1.5 0.25 0.3 0.3 0.25 Mineral oil - - - • _ . Triethyl 2-ethylhexanoate - • _ . • _ Hydrogenated polyisobutylene - _ - - • Vaseline 0.05 - - - 0.2 - Isostearyl alcohol 0.1 - - - - _ Isostearic acid 0.15 0.5 0.25 0.2 0.4 0.25 POE (30) phytosterol *1 0.09 1 0.12 0.09 1 _ POE (30) octyl lauryl ether - - - 0.12 Polyoxyethylene (60) hardened castor oil • - - - _ _ Sorbitol sesquiisostearate ※2 0.03 0.5 0.04 0.01 0.2 0.04 Sorbitol sesquioleate ※3 - • _ _ - Sorbitol Anhydride sesquistearate - . - • _ _ sorbitan trioleate - - - _ _ polyoxyethylene alkyl (C12-C15) ether phosphate (2E.O.) - - - • _ polyglycerol -2 two different hard Acid ester - - _ - citric acid 0.01 0.01 0.01 0.01 0.01 0.01 Sodium citrate 0.09 0.09 0.09 0.09 0.09 0.09 Disodium hydrogen phosphate - _ _ • Lactic acid - - _ - Sodium lactate - - - - Trisodium edetate 0.03 0.03 0.03 0.03 0.03 0.03 Evaluation Appearance L value 65 80 75 70 15 50 Stability particle size [nm] 100 90 90 100 100 120 Oscillation stability ◎ ◎ ◎ ◎ ◎ ◎ Long-term stability [〇°c] ◎ ◎ ◎ ◎ ◎ ◎ Long-term稳定 ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ 〇144584.doc -17- 201029675 [Table 3]

144584.doc -18- 201029675 [Table 4]

Substance name comparison example 1 Comparative example 2 Comparative example 3 Comparative example 4 Comparative example 5 Residual amount of water Residual amount Remaining amount Remaining amount Residual amount Polyoxyethylene (17)·Polyoxypropylene (04) copolymer Dimethyl ether - 0.3 0.3 - Polyoxyethylene (14)·Polyoxypropylene (07) Copolymer Dimethyl Ether - . _ 0.3 1,3-Butanediol 0.5 0.3 0.1 0.1 0.1 Squalane • • - - _ Olefin oligomer 0.5 - - 0.5 Mineral oil - - 0.25 - . Triethyl 2-ethylhexanoate - - 0.3 • Hydrogenated polyisobutylene - - - Vaseline - 0.3 • . _ Isostearyl alcohol - - - - Isostearic acid 0.2 0.25 0.2 0.05 POE ( 30) Phytosterol ※1 0.09 0.09 0.1 - 0.09 sorbitan sesquiisostearate ※2 0.03 0.03 - - 0.03 sorbitan sesquioleate ※3 - - - 0.1 - citric acid 0.01 0.01 0.01 0.01 0.01 Sodium citrate 0.09 0.09 0.09 0.09 0.09 Trisodium edetate 0.03 0.03 0.03 0.03 0.03 Evaluation Appearance L value <1 <1 <1 <1 <1 Stability particle size [nm] 600 1000 300 Coarse 300 Oscillation stability XXXXX Long-term stability [〇°C] Δ X Δ X △ Long-term stability [50°C] XXXXX Goodness of sexual adaptation XX Δ X Δ Refreshability Δ X Δ X Δ Non-sticky Δ X Δ X Δ Wettability 〇 Δ Δ X Δ * 1 : NIKKOL BPS-30 (manufactured by Nikko Chemicals) * 2 : ESTEMOL 182V (manufactured by Nisshin OilliO Co., Ltd.) *3 : NOFABLE SO-852S (manufactured by Nippon Oil Co., Ltd.) (Example 19) White turbid lotion -19- 144584.doc 201029675 (Formulation)% by mass Ethanol 5 Glycerin 1 1,3-butanediol 5 polyoxyethylene (17)·polyoxypropylene (04) copolymer dimethyl ether 0 polyoxyethylene (30) plant alcohol ether 0.09 sorbitan sesquiolee 0.03 dilute oligomer 0.3 isostearic acid 0.2 Sodium hexamelate 0.03 Trimethylglycine 1 Polyaspartate 0.1 α-probiotics 0.05 Thiosulfate 0.1 Green tea extract 0.1 Mint extract 0.1 White stalk root extract 0.1 EDTA (ethylene diamine Tetraacetic acid, sodium ethoxide 0.1 acetaminophen polymer 0.05 potassium hydroxide 0.02 phenoxyethanol amount of purified water remaining amount of flavor 144584.doc -20- 201029675 (Example 20) Whitening turbid lotion (formulation) mass% ethanol 10 dipropylene glycol 1

I Polyethylene glycol 1000 1 Polyoxyethylene decyl glucoside 1 Polyoxyethylene (17)·Polyoxypropylene (04) copolymer Dimethyl ether 0.4 Polyoxyethylene (30) Plant alcohol ethers 0.09 Sorbitan half Isostearate 0.03 Vaseline 0.15 Liquid Paraffin 0.15 Isostearic acid 0.2 N-Stearyl sulphate-L-glutamate 0.1 Citric acid 0.05 Sodium citrate 0.2 φ Dipotassium glycyrrhizinate 1.1 Hydrochloric acid HCl Tranexamic acid 2 Astragalus extract 0.1 Saxifrage extract 1.1 Castor extract 0.1 Trisodium edetate 0.05 p-Methoxy cinnamic acid 2-ethylhexyl ester 0.01 Dibutyl hydroxy toluene amount 144584.doc • 21 · 201029675 p-Hydroxybenzate amount of ocean deep water 3 purified water remaining amount of flavor (Example 21) Whitening turbid lotion (formulation) mass % ethanol 10 dipropylene glycol 1

Polyethylene glycol 1000 1 polyoxyethylene decyl glucoside 1 polyoxyethylene (14) · polyoxypropylene (07) copolymer diethyl ether 0.4 polyoxyethylene (30) octyl lauryl ether 0.09 sorbitol Semi-isostearate 0.03 Hydrogenated polyisobutylene 0.25 Isostearic acid 0.25 N-stearyl sulfhydryl-L-glutamate 0.1

Bismuth citrate 〇5 Sodium citrate 0.2 Dipotassium glycyrrhizinate 0.1 Hydroquinone hydrochloride 1.1 L-ascorbyl glucoside 2 Potassium hydroxide 0.4 Astragalus extract 0.1 Saxifrage extract 0.1 144584.doc -22 201029675 Castor Extract 0.1 Trisodium edetate 0.05 Pairs 2-Ethylhexyloxy cinnamate 0.01 Dibutyl hydroxytoluene <Liquid of paraben* Ocean deep water 3 Residual amount q% by mass 2 Purified water

Perfume (Example 2 2 ) White turbid lotion (formulation) Glycerol 1,3-butanediol 4 Aldehyditol 1 Polyoxyethylene methyl glucoside 1 Polyoxyethylene (14)·Polyoxypropylene (07) copolymerization Dimethyl ether polyoxyethylene (30) phytosterol ether 0.09 sorbitan sesquiolee 0.03 Camelliol 0.1 Tris-2-ethylhexanoate 0.2 Isostearic acid 0.2 Citric acid 0.02 Sodium citrate 0.08 Phenoxyethanol amount N-coconut oil fat decyl-L-arginine ethyl ester. DL-pyrrolidone carboxylic acid 0.1 144584.doc -23- 201029675 Purified water remaining amount (Example 23) White turbid lotion (formulation) )% by mass glycerol 2 1,3-butanediol 4 erythritol 1 polyoxyethylene methyl glucoside 1 polyoxyethylene (14) polyoxypropylene (07) copolymer diterpene ether 1 polyoxyethylene (30 ) plant alcohol ether 0.09 sorbitan sesquioleate 〇. 〇 3 plant citric acid macadamia fatty acid ester 〇 · 1 tris-2-ethylhexanoate glycerol 0.2 isostearic acid 0.2 citrate 〇. 〇 2 Sodium citrate 〇·〇8 phenoxyethanol amount Ν-coconut oil fat thiol-L-arginine ethyl ester. DL-pyrrolidone carboxylic acid purified water remaining amount 144584.doc 24·

Claims (1)

201029675 VII. Application for Patent Park: ι_ A liquid cosmetic containing the following components (1) to (4); (1) Polyoxyethylene. Polyoxypropylene copolymer Dialkyl ether 0 01~ 5 mass% (2) a hydrophilic surfactant selected from the group consisting of polyoxyethylene (30) phytosterol, polyoxyethylene octyl lauryl ether, and polyoxyethylene hardened castor oil 0.01 to 1.0% by mass (3) ) selected from the group consisting of sorbitan sesquioleate, sorbitan sesquiisostearate, sorbitan sesquistearate, sorbitan trioleate, polyoxyethylene alkyl (carbon number 12) ～15) oleic acid ester (2E.O.) and polyglycerol-2 diisostearate 0.001 to 0.5% by mass of the lipophilic active agent (4) All the oil contains 20% by mass or more of isostearic acid The oil is 0.01 to 2 mass. /〇. 2. The liquid cosmetic according to claim 1, wherein the component (4) contains 丨~(10)% by mass of a solid/semi-solid oil. 3. The liquid cosmetic according to claim 1, wherein the total amount of the components (2) and (3) and the ratio (mass ratio) of the component (4) are (2) + (3) : 10 : 1~1: 10. 4. The liquid cosmetic of claim 1, wherein the dispersed droplets of the oil have an average particle diameter of 50 to 300 nm. 5. The liquid cosmetic of claim 1, which is a white turbid cosmetic having an L value of 1 to 8 Å. 144584.doc 201029675 IV. Designated representative map: (1) The representative representative of the case is: (none) (2) The symbolic symbol of the representative figure is simple: 5. If there is a chemical formula in this case, please reveal the best indication of the characteristics of the invention. Chemical formula: (none) 144584.doc