TW201018479A

TW201018479A - Amylin derivatives

Amylin derivatives Download PDF

Info

Publication number: TW201018479A
Authority: TW; Taiwan
Prior art keywords: pramlintide; glu; carboxy; butanyl; hisl7
Prior art date: 2008-10-21

Application number

TW098135520A

Other languages

English (en)

Chinese (zh)

Inventor

Lauge Schaeffer

Thomas Kruse

Jesper Lau

Henning Thoegersen

Original Assignee

Novo Nordisk As

Priority date

2008-10-21

Filing date

2009-10-21

Publication date

2010-05-16

2009-10-21 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2010-05-16 Publication of TW201018479A publication Critical patent/TW201018479A/zh

Links

108010041872 Islet Amyloid Polypeptide Proteins 0.000 title abstract description 6
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239000008194 pharmaceutical composition Substances 0.000 claims abstract description 35
238000000034 method Methods 0.000 claims abstract description 15
229960003611 pramlintide Drugs 0.000 claims description 203
108090000765 processed proteins & peptides Proteins 0.000 claims description 88
125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 80
150000001413 amino acids Chemical class 0.000 claims description 60
101100323865 Xenopus laevis arg1 gene Proteins 0.000 claims description 55
102000009027 Albumins Human genes 0.000 claims description 54
108010088751 Albumins Proteins 0.000 claims description 54
125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims description 37
-1 17-carboxyheptadecanylamino Chemical group 0.000 claims description 26
239000003814 drug Substances 0.000 claims description 25
108010029667 pramlintide Proteins 0.000 claims description 25
101150111020 GLUL gene Proteins 0.000 claims description 24
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 21
125000001424 substituent group Chemical group 0.000 claims description 19
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125000000539 amino acid group Chemical group 0.000 claims description 15
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125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 13
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MPZWMIIOPAPAKE-BQBZGAKWSA-N Glu-Arg Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@H](C(O)=O)CCCNC(N)=N MPZWMIIOPAPAKE-BQBZGAKWSA-N 0.000 claims description 6
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125000000729 N-terminal amino-acid group Chemical group 0.000 claims description 6
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