200843791 九、發明說明： 【發明所屬之技術領域】 . 本發明係相關於一種醫藥組合物，尤立4 於治療鼻洋倒流之中草藥醫藥組合物。 目關於-種用 【先前技術】 當病患有感覺到喉嚨的部位有黏液 鼻則主後逆流，都稱為鼻洋倒流。因此㈣i是黏液由 的：大因素，就是鼻腔及喉部腺體所分泌：：：，症狀 流常見的原因主要為過敏體質，感冒 接角之^，倒 成的打嘖嚏亦可萨、止占畠、益y ^丨接觸冷空氣造 夏是丌」此造成鼻昂倒流的症狀。g 或躺臥時均合菸♦，出私八 7吊倒流在站立 了 ]曰毛生，由於分泌過多的 因此常導ξ々富當十， 扣/夜吊會嗆到氣管， 吊¥致鼻基或呼吸不順暢的現象， 有相當大的影響。 / 〇生活品質 一般鼻洋倒流可利用藥物或手術治 制鼻洋倒流的症狀，然而使 “方式處理，以控 如腹$「上 使用糸物常伴隨副作用產生，例 如腹馮、嘔吐、面部潮紅等， .μ ^ …、忒70全治癒而不斷復發。 另外，手術治療雖然傷口小且换Α ^、 知局4麻醉方式進行，然豆 主要仍為侵入性治療方式， 、八 物Μ乂七 目刖治療鼻涕倒流之藥 物與方法’仍有不足之處，有待進一步改進。 【發明内容】 有鑑於既有治療鼻洋倒流之藥物與方法的不足，本發 明主要係提供一種利 ^ 如 τ早条所5周製之醫藥組合物，藉由 之目的。 π扠琛之卒取物，以達治療鼻涕倒流 4 200843791 為達綱明之主要目的，本發明係以一種治療鼻洋 倒流之醫藥組合物，其係包括治療有 _ 展有效里之黃槿枝條皮層 水烈湯汁的濃縮物。 較佳的是，治療有效量為至少二 _ 0 ? 夕一兩之！槿枝條皮層水 烈涂汁；更佳的是，進而包含醫 或載劑。 -…接文之賦型劑及/ :交佳的是，醫藥上可接受之賦型劑及，或載劑為澱粉 或醣類。 ::的是，水煎湯汁之處理方法為，利黃槿枝條皮 :……中並以清水蓋過黃槿枝條皮層高度，再將 =煮沸後改以文火持續煮彿十至十五分鐘以致得該水煎 湯汁。 主媒t t疋’頁槿枝條皮層為乾燥黃槿枝條皮層或生鮮 :主枝條皮層；更較佳的是’治療有效量為三至五兩之乾 燥百槿枝條皮層所致得水前 — 于心&，野汁，更較佳的是，治療有 、、十兩之生鮮更槿枝條皮層所致得之水前、湯 汁。 声放=2:水煎湯汁之處理方法為，㈣黃槿枝條皮 :Jen广中並以清水蓋過黃槿枝條皮層高度，再將 清水煮沸後改以文少3主溪j H , 寺項”、、沸十至十五分鐘以致得該水煎 %汁。 物it :另相關於一種治療鼻涕倒流之中草藥醫藥組合 物，其係包括治療有 有效里之頁槿枝條皮層水煎湯汁。 孝父4土的是，、Ά ^ . 〜療有效ΐ為至少三兩之黃槿枝條皮層所 5 200843791 致得之水煎湯汁。 較佳的是，黃槿枝條皮層為乾燥黃槿枝條皮層或生鮮 黃槿枝條皮層；更較佳的是，治療有效量為三至五兩之乾 =槿枝條皮層所致得之水煎湯汁；更較佳的&，治療有 十至—十兩之生鮮黃槿枝條皮層所致得之水前湯 >t ° … 較佳的是’水煎湯汁之處理方法為，㈣黃槿枝條皮 二置於一容器中並以清水蓋過黃槿枝條皮層高度，再將 '、、'弗後改以文火㈣煮〉弗十至十五分鐘以致得該水煎 商汁。 藉由本發明所提供之醫藥組合物及使用方法，可使經 =發明所治療之患者有效減緩進而治癒鼻洋倒流之症狀， 並改善其生活品質，且沒有明顯副作用。 【實施方式】 為能詳細瞭解本發明的技術特徵及實用功效 照說明書的内塞爽杏 細說明如后末只她，兹進一步以下列較佳實施例，詳 別名==㈣用黃槿之枝條作為中草藥之來源。黃禮， 、…果葉祕’ $台灣海邊防風防潮的重要樹種，其葉子 :心形，加熱後可發出特殊的香味，早期鄉下的主婦常用 ，、完整乾淨的葉子當作包裏棵糕之用。 在本發明中所使用之名詞『水煎湯汁』意 主體，利用沸水將主體中之活性成 月 本發明中該主體可為中草㈣，在本發明中較佳=黃= 6 200843791 植株，該黃槿植株較佳係為黃槿枝條皮層，包含乾燥之龙 槿枝條皮層或生鮮之黃槿枝條皮層；另外， > 1 那水係指已達 沸點的熱水，其中在本發明中係以沸水煮沸十至十五八 鐘，以獲取主體内之活性成分。 五刀200843791 IX. INSTRUCTIONS: [Technical field to which the invention pertains] The present invention relates to a pharmaceutical composition, and is particularly useful for treating herbal medicine compositions for nasal reflux.目目--Use [Prior Art] When the patient feels that there is a mucus in the throat, then the main body is backflow, which is called nasal backflow. Therefore, (4) i is mucus: the big factor is the secretion of the nasal cavity and throat gland:::, the common cause of symptom flow is mainly allergic constitution, the cold joints ^, the inverted snoring can also be Sa, stop Occupy, benefit y ^ 丨 contact with cold air to make summer is a sputum. This causes symptoms of nasal reflux. g or when lying down, the smoke is ♦, and the private 8 hangs up and stands in the standing] 曰 生 生 , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , The phenomenon that the base or breathing is not smooth has a considerable influence. / 〇 Quality of life General nasal reflux can use drugs or surgery to treat the symptoms of nasal reflux, but make "the way to control, such as the belly" Etc., .μ ^ ..., 忒70 all cured and constantly relapsed. In addition, although the surgical treatment is small and the sputum is changed, the uterus is still an invasive treatment method, and the eight substances are still seven There are still some shortcomings in the treatment of drugs and methods for treating nasal reflux, which need to be further improved. [Invention] In view of the deficiencies of the drugs and methods for treating nasal reflux, the present invention mainly provides a benefit such as a five-week pharmaceutical composition for the purpose of π 琛 琛 , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , The system comprises a concentrate for treating a scutellaria sinensis spleen spleen juice. Preferably, the therapeutically effective amount is at least two _ 0 夕 夕 夕 夕 槿 槿 槿 槿 槿 槿 槿 槿More preferably, it contains a medical or carrier. -... The excipient of the article and /: The best is the pharmaceutically acceptable excipient and or the carrier is starch or sugar. :: The treatment of the decoction broth is: Lizhi lychee strip: ... and cover the height of the cortex of the sassafras with water, then = boil and then change to simmer for 10 to 15 Minutes to get the water decoction. The main medium tt疋' page lychee cortex is dry yellow lychee cortex or fresh: main branch cortex; more preferably 'the therapeutic effective amount is three to five dry dried lychee The skin caused by the cortex - in the heart &, wild juice, more preferably, the treatment has, the fresh and lychee cortex caused by the fresh water, the soup. Sound = 2: water decoction The treatment method of the soup is: (4) Astragalus bark: Jen Guangzhong and cover the height of the cortex of the yellow sassafras with clear water, then boil the water and change it to Wenshao 3 main stream j H, temple item, and boiling to ten Fifteen minutes to get the water to fry the juice. It is also related to a herbal medicine composition for treating nasal discharge, which comprises treating the lychee skin decoction soup with effective stalks. The four fathers of the filial father are, Ά ^ . ～ 疗 疗 〜 〜 〜 至少 至少 至少 至少 至少 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 2008 Preferably, the scutellaria bark layer is a dried sassafras skin layer or a fresh yellow lychee skin layer; more preferably, the therapeutically effective amount is three to five two dry = lychee skin layer resulting from decoction soup More preferably &, the treatment of the water to the soup before the fresh yellow lychee skin layer of ten to -12 two ... preferably ° 'water decoction juice treatment method, (four) jaundice The branches are placed in a container and covered with water to cover the height of the cortex of the sassafras, and then the ',, 'Focus is changed to simmer (four) and boiled for ten to fifteen minutes to obtain the decoction juice. By the pharmaceutical composition and the method of use provided by the invention, the patient treated by the invention can be effectively alleviated to cure the symptoms of nasal reflux and improve the quality of life without obvious side effects. [Embodiment] In order to be able to understand in detail the technical features and practical effects of the present invention, the description of the Nespresso apricot is as follows. Further, in the following preferred embodiment, the detailed name == (4) using the branches of Astragalus as a Chinese herbal medicine. source. Huang Li, , ... Fruit Leaf Secret ' $ Taiwan's important tree species for wind and moisture protection, its leaves: heart-shaped, can give a special fragrance after heating, commonly used in the early rural housewives, complete and clean leaves as a cake in the bag use. The term "shuijian broth" as used in the present invention is intended to be a main body, and the activity in the main body is made into a moon by boiling water. The main body of the present invention may be a middle grass (four), and in the present invention, preferably = yellow = 6 200843791 plant, Preferably, the Astragalus membranaceus plant is a yellow lychee skin layer comprising a dried dragon lychee skin layer or a fresh yellow lychee skin layer; and, > 1 the water system refers to a hot water having a boiling point, wherein in the present invention Boil in boiling water for ten to fifteen to obtain the active ingredient in the body. Five-knife
本發明主要利用截取黃槿之枝條，以清水洗淨黃禮枝 條並取下皮層|，視需要將其曬乾或濕式使用，濕式係指 直接使用生鮮之黃禮枝條皮層。將經清潔或曬乾處理的黃 禮枝條皮層以水煮方式處理，水煮方式可利用既有已知S 器皿容器或方法處理；在本發明之較佳具體實施例中，主 要利用黃槿枝條皮層放置於一容器中並以清水蓋過黃槿枝 條皮層高度，再將清水煮沸後改以文火（小火）持續煮沸 十至十五分鐘以致得該水煎湯汁，並取其湯汁服用；另外， 由於黃槿枝條皮層質輕而易浮於水面，熬煮時可視需要加 入清潔之石板或石塊，將黃槿枝條皮層壓制使其完全沉浸 於水面下。 本發明人實際將經熬煮的黃槿枝條皮層水煎湯汁給具 鼻涕倒流症狀之病患服用，其結果如下： 試驗人數··男女共六十人，取具有鼻涕倒流症狀者。 藥材處理方法：以三至五兩之乾燥黃槿枝條皮層進行 水烈’水煎方式為將黃槿枝條皮層放置於一容器中並以清 水蓋過黃槿枝條皮層高度，再將清水煮沸後改以文火持續 煮沸十至十五分鐘以致得該水煎湯汁，而後取該湯汁服 用0 服用方式：每日服用，一次或分數次將該湯汁服用完 7 200843791 畢’症狀輕微者連續服用兩 J a，鼻昂倒流症狀已有生 上病史者，連續服用五天。 有五年以 結果：經試驗後，受試者 「 T人自衣不不古畠、、故 倒流之現象進而根治，且無不良後果。 再有T昂 由本發明之結果可以發 #水…… Ί，利用本發明之黃槿枝條皮 層水烈芴汁，可以有效治療魯 昂倒流病患之症狀，同時本 ^月可進一步將該水煎湯汁加以 、 甘 /縮及/或乾燥，或配合 其他賦型劑及/或载劑，如 W叔或醣類專，以製成黃槿技 ir、皮層之水烈湯汁濃縮物， ..ra 而此進一步應用於濃縮中藥或 :他型悲之醫藥組合物，相關之濃縮及/或乾燥方法，係 技術領域中具有通常知識者可以中請前u前技術 輪易元成者，此不再贅述。 乂上所述僅疋本發明的較佳實施例，並非對本發明 作任何形式上的限制，任何 7所屬技術領域中具有通常知識 者’若在不脫離本發明所提技術特徵的範圍内，利用本發 明所揭示技術内容所作出局部更動或修•的等效實施例， 並且未脫離本發明的技術特徵内容，均仍屬於本發明技術 特徵的範圍内。 【圖式簡單說明】 益 【主要元件符號說明】 8The invention mainly utilizes the interception of the branches of the scutellaria, washes the yellow stalks with water and removes the cortex|, and uses them as needed, or the wet type refers to directly using the fresh yellow stalks skin layer. The cleaned or dried dried yellow stalk skin layer is treated by boiling, and the boiled method can be treated by using a known S vessel container or method; in a preferred embodiment of the invention, the scutellaria branches are mainly utilized The cortex is placed in a container and covered with water to cover the height of the cortex of the sassafras, and then the water is boiled and then boiled for 10 to 15 minutes with a simmer (small fire) to obtain the decoction and take the soup. In addition, since the cortex of the sassafras is light and easy to float on the surface of the water, it is necessary to add clean slate or stone when cooking, and press the cortex of the sassafras to completely immerse it under the water surface. The present inventors actually took the boiled scutellaria bark skin decoction soup to patients with symptoms of nasal reflux, and the results were as follows: The number of trials · 60 males and females, who had symptoms of nasal reflux. Medicinal material treatment method: using three to five two dry yellow lychee skin layer for watery water decoction method, the yellow sassafras skin layer is placed in a container and covered with water to cover the height of the sassafras cortex, and then the water is boiled and then changed. Continue to boil for 10 to 15 minutes with a simmer to obtain the decoction, and then take the soup for 0. Take the form: Take it daily, once or several times. Take the soup 7 200843791 Two J a, the symptoms of nasal reflux have been a history of illness, taking five consecutive days. There are five years to the results: after the test, the subject "T people are not old-fashioned, so the phenomenon of backflow and further cure, and no adverse consequences. There are T Ang from the results of the invention can be issued #水... Ί, the use of the yellow lychee skin cortex juice of the present invention can effectively treat the symptoms of the Rouen backflow patient, and at the same time, the water decocting juice can be further added, sweetened/shrinked and/or dried, or matched. Other excipients and / or carriers, such as W or sugar, for the preparation of scutellaria ir, cortex water broth concentrate, ..ra and further applied to concentrated Chinese medicine or: his type of sadness The pharmaceutical composition, the related concentration and/or drying method, those having ordinary knowledge in the technical field can be referred to in the prior art, and will not be described again. The preferred embodiments are not intended to limit the scope of the invention, and any one of ordinary skill in the art will be able to make a partial change using the technical contents disclosed in the present invention without departing from the technical features of the present invention. Or equivalent Embodiments, and without departing from the technical features of the present invention, provided they fall within the scope of the technical features of the present invention. [FIG formula [Yi] BRIEF DESCRIPTION OF REFERENCE NUMERALS 8 major components