TW200816981A - Uses of 3,3'-dihydroxyisorenieratene and related carotenoids - Google Patents

Abstract

The present invention relates to antioxidants, mixtures, preparations, colorants, vesicles, carotenoid formulations, dermocosmetics, pharmaceuticals, foods and animal feeds, and other solids or liquids or mixtures thereof which comprise 3,3'-dihydroxyisorenieratene, isorenieratene-3,3'-diquinone,2,2',4,4'-tetra-tert-butylisorenieratene-3,3'-diquinone, 3,3'-dihydroxy-2,2',4,4'-tetra-tert-butylisorenieratene or related isorenieratene compounds or have been produced using these compounds or with a method which comprises the use of these compounds.

Description

200816981 IX. INSTRUCTIONS: [Technical field to which the invention pertains] The present invention relates to the inclusion of 3,3.-di-iso-synthesis, iso-sphingo, 3,3,- _ 醌, 2, 2, 4, 4 |-Tetra-t-butylisoxylene_3,3,_diindole, 3,3,-di-diyl 2,2',4,4'-tetra-tert-butylisoxyl or related Isoprene compounds or antioxidants, mixtures, preparations, colorants, vesicles, carotenoid formulations, dermatological skin care products, pharmaceuticals prepared by using such compounds or by methods comprising the use of such compounds Food and animal feed, and other solid or liquid or mixtures thereof. The preferred embodiments can be found in the scope of the patent application and the specification. [Prior Art] Antioxidants, mixtures, preparations, colorants, vesicles, carotenoid formulations, dermatological skin care products, pharmaceuticals, foods and animal feeds, and other solid or liquid or mixtures thereof are substances with complex compositions The mixture showed high variability. Therefore, it is needless to say that the above-mentioned subject matter of the present invention and the features mentioned below may be used not only for the specific combination described in various cases but also without departing from the scope of the present invention. In other combinations. In particular, the preferred embodiments can be combined with each other. Carotenoids and other natural substances have long been used as dyes and antioxidants' and have been used in dermatological skin care products, foods and animal feeds. In fact, many yellow to red carotenoids are present as natural substances in the starting materials of food and animal feed. Therefore, carotenoids can be used in coloring agents and carotenoid formulations for human consumption. Specification DE 198 02 134 Α 1 describes the class of carrots 122883.doc 200816981 The coloring agent of the pigment aggregates. The specification DE 198 38 636 A1 describes carotenoid formulations of a combination of carotenoid β-carotene, lycopene and lutein. It should be understood that a wide range of applications raises high demands on the corresponding class of Caroline, and the latter often fails to meet these requirements to the desired extent. In particular, properties such as availability, stability, solubility, and antioxidant effects of naturally occurring guacamera are often insufficient to be used on an industrial scale. The antioxidant carotenoid used to date is astaxanthin. It is widely used as a dye with antioxidant effects in food and animal feed. In addition, the results of the ® study are available, demonstrating the positive effects of astaxanthin (for example) on the immune system, kidneys, eyes, nerves, veins and on diabetes, cancer, hypertension and general inflammatory effects (Ghazi Hussein et al., Astaxanthin) , a Carotenoid with Potential in Human Health and Nutrition, J. Nat. Prod. 2006, 69, 443-339) 虾 Due to its antioxidant properties, astaxanthin derivatives are preventable and/or therapeutically useful for many A disease caused or promoted by an oxidative process in the body or on the body. To improve the solubility of astaxanthin in aqueous media, derivatives of astaxanthin are commonly used for this purpose. At this time, astaxanthin is derivatized with a protecting group which is easily cleaved. Corresponding uses and derivatives and protecting groups which are susceptible to cleavage are described in US 2005/0065096 A1 and by Gross J et al., Cardioprotection and myocardial salvage by a disodium disuccinate astaxanthin derivative (CardaxTM), Life Sciences 75, 2004, 21 5-224 in. According to the scientific publication, the synthetic carotenoid 3,3f-dihydroxy-2,2',4,4'-tetra-tert-butylisoxanthene (BHT-carotenoid) has good antioxidant activity. 122883.doc 200816981 Nature (Beutner, S. et al., Modified flavonoids as strong photoprotecting UV absorbers and antioxidants, Advances m Colour science and Technology, 2002, 5, 103-112) has not disclosed the compound, especially in dermatological skin care products, pharmaceuticals, Industrial use in food and animal feed and especially in relatively high concentrations. SUMMARY OF THE INVENTION One of the present inventions a is labeled to obtain carotenoids which can be used differently and widely used and are easy to use in industrial applications. First of all, the goal is to provide humans and animals with good tolerance to forks and because of their superior antioxidant properties and good health properties, they can be used not only in dermatological skin care products, foods and animal feeds, but also to protect them against emulsification effects, and also through Its carotenoids have a positive effect on the health of humans and animals in the prevention or treatment of dermatological skin care products, foods and feeds. Secondly, the aim is to provide a low concentration for use in order to obtain a good antioxidant effect, and thus to provide avoidance, especially in the dermatological skin care product or the f drug portion, in food or animal feed or in the mouth, preparation, micro Carotenoids in the formulation of lipid granules, I colorants or carotenoids which have the potential for improper color effects. The alternative aspect of the target is that, based on the color effect of the class, the color effect of the color is obtained, and in particular, the desired color effect is simultaneously obtained for humans and Good compatibility of animals is possible. The good radish, the body or the other type of Hu Shi: ', ~ open> into a pigmented stabilizing effect or a liposome phase or a lipid phase stabilizing effect of the poly-chain R m 乂月日贝 or 苴He r phase /, for the use of colorants, vesicles fly /, the same class of mussels in the moon. 122883.doc 200816981 3,3,-di-iso-isomethylene, iso-sulfene _m22,4,4,_ tetra-tert-butyliso-saponene_3,m 3,m2,2w tert-butyl Iso-saponene or related iso-squalene compounds, especially the di-hydroxy-isine materials, achieve their intended goals due to their excellent and superior anti-oxidation properties with other types of convulsions. The subject matter of the invention produced by the invention is described in the context of the present disclosure. Definition The isoprene compound or compound (1) is a compound of the formula (1)

Wherein R Η or a protecting group which is susceptible to cleavage or a physiologically compatible salt thereof, R to R may be the same or different independently of each other and are Ci to C3 alkyl. A protecting group that is susceptible to cleavage is, for example, linked via an ether compound or an ester compound and is more sturdy, resveratrol or sulphuric acid or an olefinic carboxylic acid such as oleic acid, palmitate, ascorbic acid. Ester, succinate, acetalyl salicylate, or an amino acid such as an amine acid. Other thin substrates that are susceptible to cleavage can be found in US 2005/0065096 A1. 3,3'-di-iso-isodecane is a compound of formula (Ia):

122883.doc 200816981 Iso-saponene-3,3'-diindole or compound (Π) is a compound of formula (II):

2,2|,4,4匕tetra-tert-butylisoxanthene-3,3'-difluorene or anthracene-based carotenoid or compound (III) is a compound of formula (III):

3,3'-Dihydroxy-2,2',4,4'-tetra-tert-butylisoxylene or anthraquinone-like carotenoid or compound (IV) is a compound of formula (IV):

In the following, it is understood that the compound (V) should mean - an isospinene compound according to the invention or a compound (I) or -isoxenene-3,3'-dioxime or a compound (II) or -2,2 \4,4'-tetra-t-butylisoxenene-3,3 human diterpene or compound (III) or -3,3匕dihydroxy-2,21 J〆1-tetra-t-butyl iso Spanning olefin or compound 122883.doc -10- 200816981 (ιν) 〇 carotenoid carotenoid is tetraterpene, 双 double bond carbon chain linkage, 3 two ionone ringes have 9 animal sources or have been chemically combined :: Produced with microbial sources, plant sources or 咅 containing t # tI -. Salty understanding, carotenoids also heart month 3 虱 Ye Yin 'su. For example, mention may be made. spirulina, carotenoid, r腩 to 4 spirulina, Buhu ^, 胭 、, lipid-lowering glutinin, capsanthin, chili, red pigment, tomato red素素,卜萝g酸^. Even 8_胡萝_aldehyde, Bu Arg-8,-Hucai:; 广素, lutein, cryptoxanthin, canine flavin, 堇 = 夸黄素 or spotted Yellow matter. The above compound (V) belongs to the class = class of the class. If the above compound (7) is, for example, present as a component other than the other types of carrots, the class of the carotenoids should only mean other types of carotenoids which are not contained in the above substances. Dermatological skin care product "dermatological skin care product" describes a skin cosmetic, hair cosmetic, dermatological or hygiene composition and/or formulation for topical application to the skin or hair, which is suitable for (1) prevention of human skin and/or Or damage to human hair, (ii) treatment of existing damage to human skin and/or human hair, human skin and/or human hair, (iv) improvement of skin feel (feeling properties). Clearly included for decorative cosmetics (dec (10) tive cosmetic ) Spices and compositions' such as eyeliner, mascara, eye shadow, moisturizing day cream, loose powder, concealer stick L, work, lip 1*, lip liner, make-up, nail polish or bright color Glue. Also included is a composition for skin care that achieves the purpose of pharmaceutical dermatology and also considers cosmetics. Use these skin I22883.doc • 11 - 200816981 medical skin care products to aid, prevent and treat skin disorders and It can produce biological effects in addition to cosmetic effects. The dermatological skin care product according to the present invention is particularly preferably used to protect the skin from sunlight, especially UV- A dermatological skin care product that is damaged by B radiation (280 to 320 nm) and IJV-A radiation (> 320 urn). It is extremely preferred to contain lipophilic vitamins A, D, E, K and its derivatives. A dermatological skin care product that is preferably a vitamin A or a beta-carotene. The dermatological skin care product contains suitable auxiliaries and additives selected in the field of specialty applications in a cosmetic compatible medium. The auxiliaries and additives are familiar to the subject. It is known to the skilled person and can be found, for example, in cosmetic handbooks such as Schrader, Grundlagen and Rezepturen der Kosmetika [Fundamentals and formulations of cosmetics], Huthig Verlag, Heidelberg, 1989, ISBN 3-7785-1491-1, or Umbach, Kosmetik: Entwicklung, Herstellung and Anwendung kosmetischer Mittel [Cosmetics: development, manufacture and use of cosmetic compositions], Second Extended Edition, 1995, Georg Thieme Verlag, ISBN 3 13 712602 9 〇 Suitable for protecting human skin or human hair against UV radiation A dermatological skin care product comprising one or more organic combinations with one or more of the substances listed below / or inorganic photoprotective agents and / or UV filters · emulsifiers, surfactants, preservatives, essential oils, thickeners, hair polymers, hair and skin conditioners, graft polymers, water soluble or water Dispersible polyoxyxides containing polymers, gelling agents, conditioning agents, colorants, tinctures, dyes, pigments, consistency regulators, humectants, fatliquors, collagens, protein hydrolysates, lipids and/or Antioxidants. 122883.doc •12- 200816981 For the purpose of achieving the present invention, "dermatological skin care active ingredient" is an active ingredient present in the skin lotion and tons of skin care products, which is used for (1) Prevent damage to human skin and/or human hair, ((1) treat existing damage to human skin and/or human hair, (iii) care for human skin and/or human hair and '(1V) improve skin feel (feeling properties) And (iv) decoratively beautifying or improving the appearance of human skin and/or human hair. The active ingredients are selected from (eg:) natural or synthetic polymers, pigments, humectants, oils, cockroaches, protein shell enzymes, Minerals, vitamins, sunscreens, fragrances, peroxides, preservatives and preservatives, and for the prevention, treatment and treatment of skin disorders, and the biological effects of curing the general conditions of preventing oysters, regenerating or improving the skin. A group of medicinal active ingredients. Baizhi's make-up and/or dermatological skin care active ingredients are, for example, colored live knives, skin and hair stains, colorants, tinctures, bleaches, keratin hardening Quality, antimicrobial active ingredient, optical filter active ingredient, repellent active ingredient, blood-filling substance, stratum corneum separating substance and keratin-enhancing substance, anti-dandruff active ingredient, anti-inflammatory drug, keratinized substance, anti-antibiotic Oxidation or active ingredient acting as a free radical scavenger, skin moisturizing or moisturizing substance, fatliquoring active ingredient, anti-erythema or anti-allergic active ingredient, branched chain fatty acid such as 18-methylicosuccinic acid, and mixtures thereof. Other dermatological skin care active ingredients that can be used are (for example, acetic acid salicylic acid, atropine, kansui blue, chlorpyrifos and its chlorocorticoside] 7 valeric acid derivative, family vitamin Especially vitamins

Bl, vitamin B12, vitamin D, vitamin A and its derivatives such as palmitic acid retinal vinegar, vitamin E or its derivatives such as fermented strontium acetate, vitamin 122883.doc 200816981 biotin c and its like ascorbyl sugar Derivatives, as well as nicotinamide, ubiquinol, myrrh SI, polymyol, unsaturated fatty acids, such as essential fatty acids (commonly known as vitamin F), especially gamma-linolenic acid, oleic acid, twenty Carbaenoic acid, docosahexaenoic acid and its derivatives, chloramphenicol, caffeine, prostaglandin, thymol, camphor, horn 1 ene, extracts of plant and animal origin or other products, For example, evening primrose oil, borage oil or turmeric seed oil, fish oil, cod liver oil, as well as nervous amines and nervous amines, incense extract, water lily extract, licorice extract, witch hazel, anti-dandruff activity Ingredients (eg disulfide)

Selenium, zinc pyrithione, ketone, ethanolamine (ο-), gammonol, ketone ketoethanolate, agglomerate and combinations thereof, complex active ingredients, such as active ingredients from gamma-mysterol and such as pan _, chlorination dance, acetic acid mother's salt _ salt ° also # Lidi chooses, for example, Purcellin cnlKEucerh® and Neocerit® from the group of dermatological skin care active ingredients. The active ingredient is also particularly advantageously selected from the group of NO synthetase inhibitors, in particular if the preparation according to the invention is intended for the treatment and prevention of symptoms of internal and/or external skin aging, and for the treatment and prevention of UV-ray radiation Harmful effects of skin and hair. Preferably, the shame synthetase inhibitor is succinyl arginine. Furthermore, the 'active ingredient is advantageously selected from the group consisting of catechins and catechins, bile vinegar, and water from plants or plant parts: a quantity of catechins or catechins of bile acids. Extract. Its typical ingredients (such as catechins, catechins, coffee tests, vitamins, minerals, amino acids, lipids) are also advantageous. Salty understanding, the group of compounds of catechin-weathered ketone or anthocyanin, and the derivative of "catechin" "122883.doc 200816981 (category, catechin, 5,7-flavonol, 2-( 3,4-II, & I — , a basic base) bite - 3,5,7-triol). Epicatechin ((2R, 3R)-3,3,,4, 5 7 廿; ^ , , , ' ketone pentaerythritol is an advantageous active ingredient for the purpose of the present invention. It is also advantageous to have a plant extract of a certain amount of catechin, especially a green tea extract, such as from 2 poles, especially from Tea type assica), Dali tea (Camellia spec.) Camellia sinenis, c taliensis and C. inawadiensis and such teas and (for example) camellia (cameiiia)

An extract of the leaves of the hybrid of jaP〇nica). Preferred active ingredients are also from the group (·)-catechin, (+)-catechin, (-)-catechin gallate, (+ gallic catechin gallic acid Ester, (+)-epicatechin, (_)_ epicatechin, (-)-epicatechin gallate, (-)-epigal catechin, epiphytic Polyphenols and catechins of catechin gallate. "Cosmetic compatible medium" is intended to be broadly understood and means a substance suitable for the manufacture of dermatological skin care products and mixtures thereof. The above compound (V) or the above compound (V) is present in the dermatological skin care product during the product, and it is understood that the cosmetic compatible medium should only mean a substance which does not contain the above compound (V). π is a substance that does not usually cause irritation or damage after contact with human or animal skin tissue or hair. It also generally does not have incompatibility with other substances. Moreover, these substances have lower sensitization and can be used for b Sexually approved by the Sfate registrati〇n authorities for use in cosmetic preparations. These substances are cooked. It is known to the person skilled in the art and can be found, for example, in cosmetic handbooks such as Schrader, Grundlagen and Rezepturen der Kosmetika [Fundamentals and formulations 122883.doc 200816981 〇f cosmetics], Huthig Verlag, Heidelberg, 1989, ISBN 3-7785 1491.1. The compound (v) usually does not cause irritation or damage after contact with human or animal skin tissue or hair lice, but compound (7) should not be included in the concept of cosmetic compatibility materials below. Flavonoids and their derivatives The substances (also commonly referred to as "flavonoids) are also advantageous dermatological skin care active ingredients for the purposes of the present invention. On the enamel, flavonoids are usually present in glycosylated form. They are characterized by the following basic structure (giving a substitution) Location)·· Z2

Wherein Z1 to Z9 are independently selected from group 11, 〇H, milk base, and beauty

The calcined base 'sylose or (d) oxy group can be branched or unbranched and 1 to 18 carbon atoms 〇z6 "άΓ么和士卷^ ZTt glycosylation, corresponding group and oligomerization A group of glycosidic groups. The early sugar can also be preferably used in some of the preparations of the invention to more than one or more substituents Z, such as hydrazine to 6 substituents Z, wherein, as listed in the same eight, Z may especially be 〇Η Group. /, Table 1 below 122883.doc -16 - 200816981 Table 1: Flavonoids

Furthermore, the dermatological skin care active ingredient (one or more compounds) can also be advantageously selected from the group of hydrophilic active ingredients, in particular selected from the group consisting of α_decanoic acid such as lactic acid or salicylic acid or a salt thereof, such as sodium lactate Calcium lactate, ritual TEA urea, allantoin, serine, sorbitol, glycerol, milk protein, ubiquinol, polyglucosamine. It is suitable for artificial skin which is not required to be naturally or artificially irradiated with UV rays. The skin active ingredients are, for example, dihydroxypropyl-, tetra-oxetane and walnut shell extracts. Suitable keratin hardening materials such as potassium aluminum sulphate, aluminum hydroxychloride, and aluminum sulphate are generally dermatological skin care active ingredients and are also used in the suppression of sweating agents. Peroxide Decomposers The peroxide decomposers that can be used are substances from a variety of substance classes. In their relationship, it is needless to say that for use in humans and animals, only substances which do not have a detrimental effect on health at the concentrations used are used. 122883.doc -17- 200816981 A substance having suitability as a peroxide decomposing agent may be a sulfur-containing substance in which sulfur is present in an oxidation state of less than +6, wherein phosphorus is present in an oxidation oxidant of less than +5 Compounds and aromatic amines. The compound containing sulfur and phosphorus may be organic or inorganic in nature, and a substance having an organic property is preferred. Whether certain compounds are suitable as peroxide decomposers can be determined in vitro, for example, from the fact that they are soluble in a polar or non-polar solvent at a molar concentration of 〇〇5 m/1 at room temperature. The peroxide or hydroperoxide concentration is reduced by at least 2%, preferably 50% and especially 9% by weight in minutes. Substances that include • Oxide decomposers are, for example, mercaptans, dialkyl, diaryl or arylalkyl sulfides, dialkyl disulfides, dialkyl sulfoxides, sulphites, Acids and their esters and decylamines, sulfenyl esters or decylamines, thioesters, thioguanamines, thioureas, thiocarbonyl compounds, thioacetals and thioketals, which are also in cyclic form. Pyridin-2-thiol-3-formic acid, 2-methoxypyrimidincarboxylic acid, 2-methoxy-picolinic acid, 2-didecylaminopyrimidinic acid '2-didecylamino-pyridine Jia Yuwen. Further examples are described in the descriptions WO 〇 2〇 7698 and WO 〇 3〇 593 I2. Free radical decomposing agent or radical scavenger: A radical decomposing agent or a radical scavenger is a substance which can interrupt a radical reaction chain by being capable of reacting with a radical and neutralizing it. These free radicals are, for example, hydroxyl groups, free radical photoproducts, and singlet oxygen. Substances which can be used as free radical scavengers or free radical scavengers are described, for example, in DE 19739349 or WO 2005/042828. Antioxidants 122883.doc -18 - 200816981 Antioxidants are substances that protect other substances against oxidation. Antioxidants which can be used are, for example, amino acids (for example glycine, histidine, tyrosine, tryptophan) and derivatives thereof, imidazoles (for example urinary acid) and derivatives thereof such as peptides such as D, L-carnosine, D-carnosine, L-muscle and its derivatives (such as nail muscle), carotenoids, carotene (such as α-carotene, β_carrot), lycopene and Derivatives, drifting acid and its derivatives, lipoic acid and its derivatives (such as dihydrolipoic acid), gold thioglucose, chlorpyrifos and other thiols (such as sulfur reduction oxides, noodles) Glutathione, _semi-deaminic acid, cysteine, cystamine and its sugar ester, Ν-acetate, methyl vinegar, vinegar, vinegar, amyl, butyl and lauryl ester, hexadecanoyl ester, Oil ester, linoleic vinegar, cholesteryl ester and glyceride) and its salts, thiodipropionate dilaurin, thiodipropionate distearyl ester, thiodipropionic acid and its derivatives (ester) , ethers, peptides, lipids, nucleotides, nucleosides and salts), and sulfonium imine compounds in very low tolerated doses (eg pm〇l to pmol/kg) (eg, Buthionine sulfoximine, homocysteine sulfonamide, butyl thiamine, acid sulfone, valsulfameimide, hexasulfinimide, heptase Imine), as well as (metal) chelating agents (eg...hydroxy fatty acids, palmitic acid, phytic acid, lactoferrin), alpha-carboxylic acids (eg citric acid, lactic acid, malic acid), humic acid, bile acids, Bile extract, bilirubin, biliverdin, ethylenediaminetetraacetic acid (EDTA), ethyl bis(oxyethylenediaminetetraacetic acid (EGTA) and its derivatives, unsaturated fatty acids and their derivatives (eg Γ-sublinoleic acid, linoleic acid, oleic acid), folic acid and its derivatives, furanosyl sorbitol and its derivatives, ubiquinone and panthenol and its derivatives, vitamin C and derivatives (eg , ascorbyl palmitate, phosphoric acid 122883.doc -19- 200816981 anti-jj magnesium, ascorbyl acetate), fertility derivatives (eg, vitamin E acetate), vitamin A and derivatives (vitamin A palm) Ester) and benzoin resin, benzoic acid, terpene, Ri|tinic acid) and its derivatives 'α-glycosyl rutin, ferulic acid, furan methylene sorbitol, carnosine 'butyl benzyl benzene, butyl thiophene scale, dihydro guaiac Acid (nordihydroguaiacic acid), nordihydroguaiaretic acid, trihydroxybutyroin, uric acid and its derivatives, mannose and its derivatives, zinc and its derivatives, guanidine and its derivatives (such as armor Thiamine), hydrazine and its derivatives (for example, cerium oxide, trans cerium oxide). The compound can be used as an antioxidant. If the above compound (v) other than the antioxidant is used, the antioxidant should only It means that the above compound (v) does not contain other antioxidants. Antimicrobial Active Ingredient The antimicrobial active ingredient is used to destroy or inhibit the growth of microorganisms and can thus be used as a preservative or as a deodorizing substance which reduces the formation or strength of body odor. The antimicrobial active ingredients and preservatives which can be used are, for example, conventional antimicrobial active ingredients and preservatives known to those skilled in the art, such as parabens, imidazolidinyl urea, formaldehyde, sorbic acid, benzene. Tannic acid, salicylic acid, etc. Deodorant substances of this type are (for example, zinc linoleate, triclosan, alkyl decyl decanoate, triethyl citrate, ehlorhexidine). The antimicrobial active ingredients are also: Table 2: Suitable antimicrobial active ingredients. ^ ^ ^ | Soil extraction knife The E number listed in the table above is the name used in Guideline 95/2/EEC. 122883.doc -20 - 200816981 E200 Sorbic acid E227 Calcium hydrogen sulphate E201 Sodium sorbate E228 Potassium hydrogen sulphate E202 Potassium sorbate E230 Biphenyl (diphenyl) E203 Sorbic acid mother E231 O-phenylphenol E210 Benzoic acid E232 O-phenyl phenyloxide E211 Sodium benzoate E233 Thiabendazole E212 Potassium benzoate E235 Natamycin E213 Calcium benzoate E236 Tannic acid E214 Ethyl p-hydroxybenzoate E237 Sodium formate E215 Ethyl p-hydroxybenzoate E salt 238 Calcium formate E216 n-propyl p-hydroxybenzoate E 239 1 hexamethylenetetramine E217 n-propyl p-hydroxybenzoate sodium salt E249 potassium nitrite E218 p-hydroxybenzoic acid methyl ester E250 succinate sodium E219 p-hydroxybenzoic acid A Ester sodium salt E251 Potassium dioxide E252 E220 E221 E280 acid sodium sulfite, sodium bisulfite E222 E281 E223 sodium dithionite, sodium propionate, calcium propionate E282 E283 E224 two sulfite, calcium sulfite, potassium propionate E226 dioxide E 290

Other antimicrobial active ingredients and preservatives are also suitable, which are especially suitable for incorporation into dermatological skin care products and pharmaceuticals according to the present invention. The substance is (for example) 2,4,41^tris-2'-yl diphenyl ether (irgasan), 1,6-bis(4-chlorophenyldidecyl)hexane (Shawei Long), 3,4,4'-trichlorocarbon anilide, quaternary ammonium compound, clove oil, peppermint oil, thyme oil, triethyl citrate, farnesol (3,7,ll- Trimethyl-2,6,10-dodecatrien-1-ol), and the active ingredient or combination of active ingredients described in the following patent publications: DE-37 40 186, DE_39 38 140, DE- 42 04 321 , DE-42 29 707, DE-43 09 372, DE-44 11 664, DE-195 41 967, DE-195 43 695, DE-195 43 696, DE-195 47 160, DE-196 02 108, DE-196 02 110, DE-196 02 111, DE-196 31 003, DE-196 31 004 and DE-196 34 019 and patents 1228 83. doc -21 - 200816981, DE-42 29 737, 〇Ε·42 37 081, DE-43 24 219, DE-44 29 467, DE_44 23 and D (four) W. It is also desirable to use sodium bicarbonate advantageously. Microbial polypeptides can likewise be used. The others are: Di-Di-cyanobutane (4)·2·Methylmethylglutaronitrile), butylaminocarbamic acid octapropane S曰2-Guang-2-nitropropane 5-chloro-2-methyl -4. Isothiazoline·3__, 2· chloroacetamide, benzyl chloride, 2 alcohol. Also suitable as phenyl benzoyl ether, in particular, a compound known by the name phenoxyethanol is suitable as an antimicrobial active ingredient, an essential oil, because of its bactericidal and fungicidal effect on many microorganisms. It is usually, for example, a mixture of natural and synthetic fragrances used in perfumes. Natural sources of substances suitable as fragrances are extracts from flowers such as lily, lavender, rose, jasmine, neroli, and ylang, extracts from stems and leaves of, for example, geranium, sassafras, bitter orange leaves Extracts from fruits such as geranium, sorghum, scent (c-y), and juniper 'from extracts of fruit peels such as citrus, lemon, and orange, from jams such as meat, white peony, celery, Extracts of cardamom, scabbard ginger, iris, and white stalk roots, extracts from wood such as pine, sandalwood, guaia, cedar: rosewood 'from, for example, artemisia, bark, and rat tail Grass, thyme herb and grass extract 'from extracts such as spruce, fir, pine, dwarf pine needles and branches, from such things as Gupeng gum, eucalyptus, benzoin, myrrh, frankincense, callus Resin resin and balsam extract. Also suitable for animal raw materials such as 麝I Miaoxiang and Beaver. Typical synthetic materials used as fragrances are vinegar type, shout type, road type 122883.doc -22- 200816981 type, class type, alcohol type and hydrocarbon type product. The ester type aromatic compound is, for example, benzyl acetate, phenoxyethyl isobutyrate, t-butyl sulphate acetate, benzoic acid acetate, dimethyl benzyl carbene acetate, phenyl acetate Ester, benzoic acid benzoate, benzyl formate, ethylmethyl phenylglycine, s-cyclohexyl propionic acid allyl ester, sulphate propionate and benzyl salicylate. The ether includes, for example, a benzyl ether, and the aldehyde includes, for example, an alkanal having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, rabbit ear oxalic acid #工基香茅、, 兰兰骏 and bourgeonal, ketones including (for example) ionone, (X-isoindenyl ionone and methyl cedar ketone, alcohol including anethole, citronellol, eugenol, Isoeugenol, vanillyl alcohol, linalool, phenylethanol and teri〇neol, the hydrocarbons mainly include hydrazine and balsam. However, it is preferred to use a mixture of different fragrances which together produce a desirable fragrance. Relatively low volatility essential oils are also suitable as essential oils or fragrances' such as sage oil, golden chrysanthemum; from, clove oil, bee flower oil, peppermint oil, cinnamon leaf oil, linden oil, juniper oil, shore orchid #根油, mastic oil, guppy gum oil, labolamim oil and lavender oil. Preferably, citrus oil, dihydrogeranol, indolinaldehyde, and new orchid are used alone or in a mixture. Aldehyde, citronellol, phenylethanol, hexyl cinnamaldehyde, vanilla Benzylacetone, rabbit ear aldehyde, linalool, Boisambrene 8For cut, ambroxan, 吲哚, hedione, sandelice, lemon oil, citrus oil, orange oil, allyl pentane Glycolate, Cycl〇Vertal, lavender oil, sage oil, 厥嗣, Botan geranium oil (geranium 〇il b〇urb〇n), salicylic acid = ester, Vertofix8Coeur, IS0-E_Super8 Run 〇仙一:义a成橡122883.doc -23- 200816981 :, ualdein γ, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide, nmillate, ir〇tyl and fl〇ramat 〇 spices It is a mixture of money-flavoring substances or flavoring substances (fragrance substances) which are especially intended to give a specific odor or taste of the food. 16 Therefore, the perfume may contain a substance which can also use 2 essential oils or fragrances. In addition to a large amount of perfume f, the fragrance may be Contains other substances such as solvents, carriers, preservatives and antioxidants. Perfume: consists of natural flavor materials, perfume materials of the same nature, artificial flavors 2, flavor extracts, reaction flavors and smoke flavors. shell Natural flavor materials, perfume materials of the same nature and artificial flavors, shellfish can be biochemically synthesized or fully synthesized, and exist in free form or as a glycosidic bond (bonded perfume substance). Suitable as a spice. The substances are almost all belonging to the following groups: alcohols, aldehydes and ketones, esters, lactones, succulents and heterocycles, such as furan derivatives, pyrazines, thiazoles or thiophenes, seven hemiquinones, thiols, sulfides, Sulfide, trisulfide, tetrasulfide φ and pentasulfide, trithiolane, thioester, alkenal, sulphurized glucose or isothiocyanate. As a perfume substance, it is possible to use, for example, α·ionia S, Ionone, γ-ionone, 2-ethylidene-1-pyrroline, (2Ε,4Ζ)-decenoic acid ethyl ester, double ( 2_Methylfuranyl)disulfide, 2-methyl-methylsulfonylfuran, (+)·cabinone, (+MS)-carnation, (+)-(R)·堇· 1-ene-8-thiol, citral, nectar, geranyl, citronellal, vanillin, diacetyl, maltol '2-methoxy-3-isobutylpyrazine, 4 -(4-hydroxyphenyl)_2-butanone, butyric acid, methyl ketone, ethyl acetate, acetoin, butyl acetonide, 2,3-dione, hydrazine-digested vinegar (γ· 122883.doc -24- 200816981 dexalactone), γ·lactone, 3_ethyl-5-methyl+2 + trithiopurine, 12-dithiolane-4 -caronic acid , 1,2-dithioindole-4-calonium phthalate, i,2-dithiacyclopentene, methyl thioacrylate, 3-(methylthio)thiopropionate methyl ester, 1 -penten-3-one, 1-nitro-2-phenylethene, 2-alkyl-3-methoxypyrazine, 2-isopropylpyrazine, 2-isobutylpyrazine, 2 _Second butyl azine, (E)·2·nonenal (E,z)-2,6-nonadienal, (E,E)-2,4-nonadienal, hexanyl-alcohol and (z)-3-hexene-alcohol, (Ε, Ζ)-2,6-nonadienal, (Ε)- and (Ζ)·2-nonenal, (Z)-l,5-octadiene-3-oxime, 2-isopropyl- 3-methoxyl is more than hydrazine, 2,5-dimethyl.比, 2-ethyl·3,6-dimercaptopyrazine, (£)-2-nonenal, (£)-2-nonenal, $$)-2,4-decadienal , 2_2,2-butyl-3-oxopyrazine, (ε,Ζ)-2,6-nonadienal, (Ε,Ε)-2,4-decadienal, 2-alkyl -3·methoxypyrazine, 3-ethyl-5-methyl-1,2,4-trisulphate, 1,2-dithioindole-4-carboxylic acid, l,2-dithiacyclopentane Bismuth, 2-ethenylthiazole, geosmin, hexanal, (ζ)_3_hexanoic acid, (ε)·2·hexenoic acid, caproic acid, β-thione, 1·pentanone, 3 -methyl butyl, 2-isobutylthiazole, dimethyl sulfide, 1-nitro-2-phenylethane, eugenol, thiopropanal, 3-methylbutyric acid (Ε, Ζ)- 2,6-nonadienal, (a) _(r) _ xiang bud, (-)-(R)-l-octyl-3-ol, (a)-(R) octyl -3-ol, benzene A jun, fennelaldehyde, 2-aminobenzoquinone, methyl ortho-benzoyl benzoate, 〗 〖, 3-dimethoxybenzene, coumarin, herbicide, limettin . Examples of oils, fats, and waxes that can be used in oils, fats, and waxes are: hydrocarbon oils such as paraffin oil, purcellin oil, total squalene, and microcrystalline solutions in such oils; Animal oil or vegetable oil 'such as sweet almond oil, avocado oil, sea bream 122883.doc -25- 200816981 oil, lanolin and its derivatives, castor oil, sesame oil, eucalyptus oil, jojoba oil, quartz neon Hogangan oil, hoPl〇stethuS oil, the distillation starting point at atmospheric pressure is about 25 〇 and the distillation end point is 41 (TC mineral oil, such as petroleum jelly, saturated or unsaturated Esters of fatty acids, such as alkyl myristate, such as isopropyl myristate, butyl myristate or cetyl myristate, cetyl stearate, ethyl palmitate or isopropyl palmitate , octanoic acid or citric acid triglyceride and ricinoleic acid cetyl ester, or ketone oil soluble in other oils, such as dimethyl polyoxyalkylene, methyl phenyl polyoxy siloxane and polyoxyl Glycol copolymers, fatty acids and fatty alcohols, fatty ketones, fat 'jun, fatty ethers and fatty carbonates For example, laurel and distearyl, or fatty acids such as stearic acid, hydroxystearic acid or dodecanoic acid, olefin epoxides having Cu-C 22 carbon atoms and having Cu-C 22 carbons a ring-opening product of an aliphatic alcohol of an atom and/or a polyol having /(a) carbon atoms and a C2-C1G hydroxyl group, and a mixture thereof. %% of the examples used are: Brazil's standard palm, Kandy Rica , bee soil, microcrystalline mash, mantle and Ca, Mg and A1 oleate, tetradecanoate, linoleate and stearate. Oils, fats and waxes are also advantageously selected from the group consisting of: Phospholipids and fatty acid triglycerides, ie, triglycerides of saturated and/or unsaturated, branched and/or unbranched alkanoic acids having a chain length of C8-C24, especially Cl2-Cl8 carbon atoms. The triglyceride may, for example, be advantageously selected from the group consisting of synthetic, semi-synthetic and natural oils such as olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, castor oil. , wheat germ oil, grape seed oil, oyster sauce, evening primrose oil, Australian walnut oil and the like 122883.doc -2 6 - 200816981. Other polar oil components may be selected from the chain length C3_C3 (^@ carbon atom saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acid and the chain length is a carbon atom saturation And/or a group of esters of unsaturated, branched and/or unbranched alcohols, and selected from aromatic carboxylic acids and having a chain length of C3_C3G carbon atoms saturated and/or unsaturated, branched and/or undivided a group of esters of alkaloids. The ester oils may advantageously be selected from the group consisting of isopropyl myristate, isopropyl sulphate, hard 曰 isopropyl ketone, isopropyl oleate Vinegar, n-butyl sulphate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isodecyl stearate, isodecyl isononanoate, 2-ethylhexanoic acid Ester, 2-ethylhexyl laurate, 2-hexyl decyl stearate, 2-octyldodecyl palmitate, oleic acid oleic acid, oleic acid, erucic acid , cetyl carbonate (cetiol CC) and cocoglyceride (c〇c〇glyceride) (my 331), butanol monocaprylate / dicaprate and dibutyl adipate, and these Synthesis, semi-synthesis and natural mixtures of esters, Such as jojoba oil. Additionally, the one or more oil or wax components may advantageously be selected from the group consisting of branched and unbranched φ^ and hydrocarbon waxes, polyolefins, oxime oils, dialkyl ethers or saturated or unsaturated 77 or unbranched A group of alcohols. Among the polyolefins, polydecene is preferred, and any mixture of the or wax components is also desirably used for the purpose of the present invention. Suitably, it may be advantageous to use a wax such as cetyl palmitate as the virgin component of the oil phase. One or more oil or soil components are also beneficial to k. Free group of the following components: · Ethyl stearate 2 - ethylhexyl ester, octyl undecyl alcohol, isodecyl isononanoate, isodecane 2, ethylhexyl cocoate, benzoic acid 0:12-indole 5 alkyl ester, caprylic acid / capric acid triglyceride, dioctyl ether. a mixture of benzoic acid Cl2_Ci5 alkyl ester and 2-ethylhexyl isostearate 122883.doc -27- 200816981, a mixture of c12-c15 alkyl benzoate and isophthalic acid, a mixture of <RTIgt; It is advantageous to use a mixture of C12.Cl5_, isostearic acid 2, and isodecanoic acid. It is especially preferred to use an oil having a polarity of 5 to 50 mN/m of fatty acid triglyceride, especially soybean oil and, or almond oil. Additionally, the - or a plurality of oil or wax components may advantageously be selected from the group of gibbutol (G and bet alcoh〇i). The gibbutol is named after the first description of its preparation of Mareel G (10) bet. It is based on the following reaction equation, ά Catalyst R—

R L

OH2-OH is formed by oxidizing an alcohol to obtain an aldehyde, by aldol condensation of an aldehyde, from the aldol removal water and the hydrogenation of acetonitrile. The gibbutol is liquid even at low temperatures and hardly licks the skin m, which can be advantageously used as a fatliquoring, fatliquoring and fatliquoring component in cosmetic compositions. The use of gibbutol in cosmetics is known per se. These are mainly characterized by the following structure: R-CH-CHpH R6 Here, R5 and R6 are usually unbranched alkyl groups. Advantageously - use gibote alcohol, wherein R5 = propyl, butyl, pentyl, hexyl, heptyl or octyl, and R = hexyl, heptyl, octyl, decyl, decyl, undecyl , eleven burning base, thirteen burning base or fourteen burning base. Particularly preferred gibbutol is 2-butyl octanol (commercially available, for example, lsofol® 12 (Condea)) and 2-hexyl decyl alcohol (commercially available, for example, 122883.doc. 200816981 lsof〇l®16 (Condea)). Mixtures of gibbutol, such as a mixture of 2-butyl octanol and 2-hexyl decyl alcohol (commercially available, for example, lsofol 014 (Condea)) may also be advantageously used. These oils or waxes may also be advantageously used. Any mixture of components. In addition, 'although it is preferred to use an additional oil or wax set other than anthrone oil, the oil or soil component may advantageously have a certain amount of cyclic or linear sulphuric acid/by or Oil composition. Low molecular weight polysulfide or oleanol oil is generally defined by the following formula: R7

8 I R—Ο—Si~〇—R9 _1 1Π High molecular weight polyoxyl or fluorenone oil is usually defined by the following formula: R7 R8 ---0—Si~〇—Si—

Wherein the ruthenium atom may be substituted here with the same or different alkyl and/or aryl groups as shown in the general group R7 to R10. However, the number of different groups is not necessarily limited to at most four. This can be assumed to be a value between 2 and 200 。. Cyclic polyfluorene oxide can also be advantageously used. Cyclic polyfluorene is usually defined by the following formula: R7 R8 Η-0-Si-o-si-

Wherein the ruthenium atom can be represented here by the group R7 to Ri 〇 in the general term 122883.doc • 29· 200816981 The value is considered to be the number of 矽 可能 可能 可能 可能 + + - , phenyl trioleate τ is also selected as decyl ketone oil 0 苴 矽 ' ' 例如 例如 例如 例如 例如 例如 例如 例如 例如 :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: :: Poly-stone oxy-fired (octamethylcyclo)oxygen), hexamethylcyclotris-di- 2:-methyloxane, poly(methylphenyloxane), cetyl-polyoxyl Alkane, Twenty-two, @&1, _, . 70-milyl-polyoxyalkylene oxide are also desirably used for the purpose of the present invention. Also advantageous are cyclomethicone and isodecanoic acid. a mixture of hexaester and 环 々, κ 聚 虱 及 and 2-ethylhexyl isostearate are mixed with them. However, there are also a few hundred of them. The side chain is derivatized, for example, by an oxime ketone having a composition similar to that of the above-mentioned compound by 5 ethoxylation and/or nuclearization, work & Oils include, for example, polyoxane-poly The base-polymerization copolymer is known, for example, as a (tetra)-based dimethyl agglomerate. The argon-oxygen (octamethylcyclotetrazepine) is particularly advantageously used as the oil. Advantageously, the moon fat and/or wax may be selected from the group consisting of plant butterflies, animal butterflies, mineral bad and petrochemicals. For example, Candidula, Brazilian brown _, Japanese soil, thatch, Guaruma wax, rice bud oil, 4 t lower teeth, waxy wax, berry wax, small crown coconut wax, montan wax, jojoba, fan, olive oil, beeswax, shellac Wax, whale wax, lanolin (wool bad) 'tail oil 胄, ground (e(10)in), 壤Z〇kerite (地(4)), stone sign and microcrystalline 壌 are beneficial. Favorable fats and/or soils are chemically modified waxes and synthetic alfalfa, such as Sync Lan a, HRC (three, succinate (IV)) and (10) rain ^ i i22883.doc -30- 200816981 CCCu-C36 fatty acids), And synthesis of brown coal ester soil, saso〇l wax, hydrogenated jojoba wax, beeswax such as dimethoxane copolyol and/or c3 (rC5 alkylated beeswax) Beeswax, ricinoleic acid ointment such as Tegosoft@CR, polyalkylene wax, polyethylene glycol wax, and chemically modified fats such as hydrogenated vegetable oils (eg hydrogenated castor oil and/or hydrogenated coconut fatty acid glycerol) Ester), such as triglyceride of hydrogenated soybean glyceride, trihydroxystearyl, fatty acid, fatty acid ester and ethylene glycol ester, such as stearic acid c2 (r Cw burnt ester, alkyl hydroxystearate stearate) Ester and/or montanic acid ethylene glycol S. In addition, certain organic germanium compounds having physical properties similar to those of the specified fat and/or wax component, such as stearoxytrimethylnonane, are also advantageous.

The fats and/or waxes may be used in the compositions individually or in a mixture. Any mixture of the components and the components may also be advantageously used for the purposes of the present invention. The oil phase is advantageously selected from the group consisting of 2-ethylhexyl isostearate, octyldodecanol, isodecyl isononanoate, butanediol dicaprylate / diterpene Acid ester, ethyl cocoate, benzoic acid hydrazine 12-decane 15 alkyl ester, caprylic acid/capric acid triglyceride, dioctyl decyl ether. a mixture of octyldodecanol, caprylic acid/capric acid triglyceride, dioctyl decyl ether, dioctyl phthalate, a mixture of cocoa glycerides or a mixture of alkyl benzoate and 2-ethylhexyl isostearate, Benzoic acid ^^2^. a mixture of an alkyl ester and a butyl group, an ethylene glycol and a dioctanoic acid _ / dioxin, and a mixture of benzene f WML, 2, ethylhexyl isostearate and isodecanoic acid advantageous. Among the smokes, paraffin oil, cycloalkylene hydrocarbon, keratin, horned ene, hydrogenated polyridindene and polydecene are advantageously used for the purpose of the present invention. 122883.doc -31- 200816981 Oil may also be selected from the group of phospholipids. Phospholipids are phosphates of deuterated glycerol. The most important of the phospholipid tests are, for example, egg fat, which is characterized by the following general structure: R- 0 H2C—0-

Ό—CH

〇JL -R12 〇i II H2C_〇一ρ—〇一CH^ 〇一-ΟΗό CH, L3 -N—CHq I 3 CH0 where R11 and R12 usually have 15 or 17 carbon atoms and up to 4 cis Unbranched aliphatic groups of double bonds.

According to the invention, Merkur Weissoel Pharma 40 from Merkur Vaseline, Shell Ondina® 917 from Shell & DEA Oil, Shell Ondina 0 927 ^ Shell Oil 4222, Shell ΟηάΙηα@933 ^ Pionier® 6301 S, Pionier 8 2071 (Hansen & Rosenthal It can be used as a paraffin oil which is advantageous according to the invention. Suitable cosmetically compatible oils and fat components are described in Karl-Heinz Schrader, Grundlagen and Rezepturen der Kosmetika [Fundamentals and formulations of cosmetics], Second Edition, Verlag Htithig, Heidelberg, pages 319-355, here Reference is made to all of its categories. Ethoxylated glycerol fatty acid esters which can be used for ethoxylated glycerol fatty acid esters are, for example, PEG·10 olive oil glyceride, PEG-11 avocado glyceride, PEG-11 cocoa butter glyceride, PEG·13 sunflower oil glyceride, PEG-15 glyceryl isostearate, PEG-9 coconut fatty acid glyceride, PEG-54 hydrogenated castor oil, PEG-7 hydrogenated castor oil, PEG-60 hydrogenated castor oil, Jojoba oil ethoxylate 122883.doc •32· 200816981 (PEG-26 jojoba fatty acid, PEG-26 jojobaol), glycerol-5 cocoate, PEG-9 coconut fatty acid glyceride, PEG -7-cocoglyceride,|>EG_45 brown nucleoli oil glyceride, PEG-35 castor oil, eucalyptus oil PEG-7 ester, ?〇-6 octanoic acid/capric glyceride, ? $〇-10 olive oil glyceride,? £(}_13 Sunflower oil glyceride, PEG-7 hydrogenated castor oil, hydrogenated palm kernel oil glycerin ? ? ugly 0-6 ester, ? 0-20 corn oil glycerin | purpose, ? 0-18 glycerol base oil Coate cocoate, PEG_4 hydrazine hydrogenated sesame oil, PEG-40 castor oil, peg-60 hydrogenated castor oil, PEG-60 corn oil glyceride, PEG-54 hydrogenated castor oil, PEG-45 palm kernel oil glyceride, Peg-35 castor oil, peG_8 decanoic acid glyceride, PEG-60 almond oil glyceride, peg-60 evening primrose glyceride, PEG-200 hydrogenated palmitic acid glyceride and PEG-9 bisisostearic acid glyceride. Base oil

The car jia ethoxylated oil is PEG-7 cocoglyceride, peG_9 cocoa glyceride, PEG-40 hydrogenated castor oil, ΡΕ<3·2〇〇 hydrogenated palmitate. Ethoxylated glycerol fatty acid esters are used in a variety of applications in the form of aqueous cleansing formulations. A glycerin fatty acid having a low degree of ethoxylation (3 to 12 ethylene oxide units) is generally used as a fatliquor for improving skin feel after drying. A glycerol fatty acid having a degree of ethoxylation of about 30 to 50 is used as a cosolvent for a nonpolar substance such as essential oil. A glycerin fatty acid having a high degree of ethoxylation is used as a thickener. A common feature of all of these substances is that after dilution with water, they give a specific sensation to the skin during application. Interface Activeness Suitable surfactants are all surface active and detergent actives. For example, it is possible to use: phosphates and salts, such as DEa, ip / tartan _ -10 酉 酉 酉曰 and one laurel scale - 4 vinegar vinegar 'burning performance Acid salts, such as sodium sulphate monoester sulfate, sodium Cu-m olefin sulfonate, lauryl sulfonate, sodium sulfonate and PEG-3 cocoamine magnesium sulfate, carboxylic acids and derivatives, such as guanidine Quinic acid, stearic acid, magnesium alkoxide and zinc undecylenate, ester carboxylic acid, such as stearic acid calcium lactate, lauryl ether-6 citric acid ester and PEG_4 lauryl amine An ester formed by esterifying a carboxylic acid with ethylene oxide, glycerin, sorbitan or other alcohol, an ether such as an ethoxylated alcohol, an ethoxylated wool, or an ethoxylated polyoxoxime, Propoxylated POE(R), and calcined benzoate such as lauryl glucoside, thioglycoside and cocoglycoside saponin suitable polysorbate are, for example: -polyethylene oxide ( 20) sorbitan monolaurate (Tweerl 2〇, CAS No. 9005-64-5) - Polyoxyethylene (4) sorbitan single laurel Ester (Tween 21, CAS No. 9005-64-5) - Poly(ethylene oxide) (4) sorbitan monostearate (Tweeil 61, CAS No. 9005-67-8) - Polyoxyethylene (20) Sorbitan tristearate (Tweerl 65, CAS No. 9005-71-4) - Polyoxyethylene (20) sorbitan monooleate (Tween 80, CAS No. 9005-65·6) - Poly Ethylene oxide (5) sorbitan monooleate (Tweeil 81, CAS No. 122883.doc -34 - 200816981 9005-65-5) - Polyoxyethylene (20) sorbitan trioleate (Tween 85) , CAS number 9005-70-3). Particularly advantageous are, inter alia, polyoxyethylene (20) sorbitan monopalmitate (Tween 40, CAS No. 9005-66-7) - polyoxyethylene oxime (20) sorbitan monostearate (丁界6^]160, CAS No. 9005-67-8) ° Conditioner® The regulators that can be used are (for example) listed in International Cosmetic

In Part 4 of the Ingredient Dictionary and Handbook (Vol. 4, Editor: R. C. Pepe, JA Wenninger, G. N. McEwen, The Cosmetic, Toiletry, and Fragrance Association, 9th edition, 2002), the keywords are Hair conditioner, moisturizer, skin conditioner, skin conditioner - emollient, skin conditioner - moisturizer, skin conditioner - hybrid, skin conditioner - occlusive agent and all compounds of skin care agent, and with '' Water® Solubility Modifiers and “Oil Soluble Modifiers” are listed in EP-A 934 956 (pages 11-13) for all compounds. Other materials which can be advantageously used as conditioning agents are, for example, compounds which are referred to as polytetra-ammonium according to INCI (especially polytetra-ammonium-1 to poly-quaternary ammonium-5-6). Substances which can be used include, for example, polymeric quaternary ammonium compounds, cationic cellulose derivatives, and polysaccharides. The compounds in the table below can also be used as conditioning agents. 122883.doc -35· 200816981 Table 3: Substances that can be advantageously used as regulators

INCI name CAS number polymer type example (trade name) Poly four money-2 CAS 63451-27-4 urea, with 1, Γ-oxy double (2-chloroethane) Ν, Ν '- double [3 -(Dimethylamino)propyl] polymer Mirapol® A-15 polytetra-ammonium-5 CAS 26006-22-4 acrylamide, methyl-sulfate β-methacryloxyethyl triethyl Ammonium polytetra-ammonium-6 CAS 26062-79-3 Barium chloride, bismuth-dimercaptopropenyl-2-propenyl ammonium Merquat® 100 polytetra-ammonium-7 CAS 26590-05-6 Barium chloride, Ν_ Dimercaptopurine-2-propenyl-2-propanyl ammonium, 2-propenylamine Merquat® S polytetracade-10 CAS 53568-66-4 > 55353-19-0, 54351-50-7 , 68610-92-4, 81859-24-7 Quaternary ammonium salt of ethyl cellulose Celquat® SC-230M, Polymer JR 400 polytetra-ammonium-11 CAS 53633-54-8 vinyl pyrrolidone / A Didecylaminoethyl acrylate copolymer / diethyl sulphate reaction product Gafquat® 755N poly quaternary according to-16 CAS 29297-55-0 vinyl pyrrolidone / methyl chlorinated vinyl imidazolium copolymer Luviquat 8 HM552 Poly Quaternary Key-17 CAS 90624-75-2 Mirapol® AD-1 Polyquarium -19 CAS 110736-85-1 Quaternary Ammonium Water-Soluble Polyethylene Suppository Polytetra-ammonium-20 CAS 110736-86-2 Tetra-ammonized Polyethylene Octadecyl Ether Dispersible in Water Polytetra-ammonium-21 Concentrate Oxane polydimethyldimethylammonium acetate copolymer Abil® B 9905 poly quaternary-22 CAS 53694-17-0 dimethyldiallyl chlorohydrin/acrylic copolymer Merquat® 280 poly quaternary钱-24 CAS 107897-23-5 Hydroxyethyl cellulose polymerized quaternary ammonium salt Quartisoft® LM-200 poly quaternary ammonium-28 CAS 131954-48-8 vinyl chloropyrrol brewing [/ chlorinated methacrylic acid Aminopropyltrimethylammonium copolymer Gafquat® HS-100 polytetraammonium-29 CAS 92091-36-6, 148880-30-2 has been reacted with propylene oxide and quaternized by epichlorohydrin Polygluconate Lexquat ® CH I22883.doc -36 - 200816981 Polytetra-ammonium-31 CAS 136505-02-7, 139767-67-7 by DMAPA acrylate/acrylic/acrylic acrylonitrogen copolymer and Polymerized quaternary ammonium salt prepared by the reaction of diethyl sulfate Hypan ® QT100 poly quaternary ammonium -32 CAS 35429-19-7 N,N,N-trimethyl-2-(2-carboxyl) -oxypropenyl)oxy Ammonium ethoxide, polymer quaternary ammonium salt with 2-propenylamine amide-37 CAS 26161-33-1 polytetra-ammonium-44 vinyl pyrrolidone and quaternary ammonium imidazoline copolymer quaternary ammonium salt Other materials which may be advantageously used as conditioning agents are, for example, cellulose derivatives and quaternized ammonium guar derivatives, especially guar hydroxypropyl ammonium chloride (for example, Jaguar Excel®, Jaguar C 1628) (Rhodia), CAS 65497-29-2, CAS 39421-75-5) Further, nonionic poly-N-vinylpyrrolidone/polyvinyl acetate copolymer (for example, Luviskof VA 64 (BASF Aktiengesellschaft)) An anionic acrylate copolymer (for example, Luviflex® Soft (BASF Aktiengesellschaft)) and/or an amphoteric amide/acrylic acid ester/methacrylate copolymer (for example, Amphomer 'National Starch) may advantageously be used according to the present invention. The invention is useful as a conditioning agent. Powder Feedstock Adding a powder feedstock can generally be advantageous. Various materials can be used as the powder raw material. It is especially preferred to use talc. Dyes Suitable dyes are all dyes or coloured substances which are liquid or soluble in solvents, for example in application media. For dermatological skin care products, pharmaceuticals, foods and animal feeds, it is preferred to use dyes suitable for use on humans and animals, that is, they generally do not exhibit health hazards or allergies. 122883.doc • 37- 200816981 is used and approved. Examples of such dyes are listed in the publication of the Dyes Commission of the German Research Society, ''Kosmetische Farbemittel" [Cosmetic colorants], published in Verlag Chemie, Weinheim, 1984. Compound (V) can be used as a dye. If the above compound (V) other than the dye is used, the dyes should only mean other dyes which do not contain the above compound (V). Pigments The substances which can be used as pigments are those which are almost insoluble in the application medium and which can be inorganic or organic. Inorganic-organic mixed pigments are also possible. The preferred ones are inorganic pigments. The advantages of inorganic pigments are their excellent light stability and resistance to weather and temperature. The inorganic pigment may have a natural source, for example, from chalk, vermiculite, hetero-iron-manganese clay, smectite, forged iron-rich loess or graphite. The pigment may be a white pigment such as titanium dioxide or zinc oxide, a black pigment such as iron oxide black, a colored pigment such as dark blue or iron oxide red, a luster pigment, a metallic effect pigment, a pearlescent pigment, and a fluorescent or phosphorescent pigment, of which preferably At least one of the pigments is a colored, non-white pigment. Metal oxides, hydroxides and oxide hydrates, mixed phase pigments, sulfur-containing strontium sulphates, metal sulfides, double metal cyanides, metal sulphates, complexes and acid salts, and metals themselves (bronze pigments) ) is suitable. In detail, titanium dioxide (CI 77891), black iron oxide (CI 77499), yellow iron oxide (CI 77492), red and brown iron oxide (CI 77491), manganese violet (CI 77742), dark blue (sulfonic acid decanoic acid Sodium Al, CI 77007, Pigment Blue 29), Chromium Oxide Hydrate (CI 77289), Iron Blue (Iron Ferricyanide, CI 77510), 122883.doc •38- 200816981 胭月曰红(胭脂虫) suitable. Particularly preferred are mica-based pearlescent pigments and colored pigments which are subjected to metal oxides or metal oxychlorides such as titanium dioxide or bismuth oxychloride and, where appropriate, such as iron oxides, iron ore, dark blue, rouge Other colors such as red impart a coating to the substance, and wherein the color can be determined by the change in layer thickness. Pigments of this type are sold, for example, under the trade names R〇na8, Colorona8, Dichroi^ and Timiron8 (Merck). Organic pigments are, for example, natural pigments such as sepia, garcinia, lunar charcoal, Cassel brown, blue, chlorophyll and other φ plant pigments. Synthetic organic pigments are, for example, azo pigments, anthraquinones, indigo, dioxazines, quinacridones, phthalocyanines, isoindolinones, anthraquinones and piperidiniums, metal complexes, basic blues And diketopyrrolopyrrole pigments. Pearlescent Agents Substances suitable for use as pearlizing agents are those which produce or impart a shine effect. By way of example, the pearlescent agents are alkylene glycol esters, especially ethylenyl distearate; fatty acid alkanolamines, especially coconut fatty acid di-p-ethanolamine; partial glycerides, especially stearin Acid monoglyceride; multi-component, optionally substituted by a carboxylic acid with a fatty alcohol having a GC: 22 carbon atoms, especially a long-chain ester of tartaric acid; fat, such as a fatty alcohol having a total of at least 24 carbon atoms , fatty ketones, fatty aldehydes, fatty ethers and fatty strontium carbonates 'especially lauryl ketone and distearyl ether; fatty acids such as stearic acid, hydroxystearic acid or behenic acid, having Cu_C 22 carbon atoms A ring-opening product of a vapor of each of the olefins with a Cu-C: 22 carbon atoms and/or a polyol having c2_cn carbon atoms and CVCb hydroxyl groups, and mixtures thereof. 122883.doc • 39 · 200816981 Thickeners Thickeners are substances that have a viscosity-increasing effect. For example, it can be used to increase the viscosity of the mixture. The thickeners which can be used are, for example, cross-linked polyacrylic acids and derivatives thereof, such as tri-gum, agar, alginic acid or hydroxyethyl cellulose, compared to their (four) substances, such as citric acid or ketone. Cellulose derivatives of methine cellulose, fatty alcohols, monoglycerin and fatty acids, polyvinyl alcohol and polyethylene are burned together. A nonionic thickener is preferably used. Repellent Active Ingredients Repellent active ingredients are compounds that are capable of repelling or expelling certain animals, particularly insects, from humans or animals, such as beneficial animals and livestock. For example, the following may be used for this purpose: 2_ethyl", 3·hexanediol, ν, ν•diethyl-m-toluidine, and the like. Suitable congestive substances for stimulating blood flow through the skin are, for example, essential oils such as dwarf pine extract, lavender extract, rosemary extract, juniper berries extract, horse chestnut extract, zenwood leaf extract, Hay flower extract, ethyl acetate, camphor, menthol, thin oil, rosemary extract, eucalyptus oil, and the like. Suitable for the separation of the stratum corneum and the horny proliferative substances are, for example, salicylic acid, calcium thioglycolate, thioglycolic acid and salts thereof, sulfur and the like. Suitable anti-head genus active ingredients are, for example, sulfur, sulfur polyethylene glycol sorbitan monooleate, sulfur polyethoxylated phytosan (four) fur ricinol p〇lyeth〇xylate) Zinc, bismuth, etc. Suitable anti-inflammatory drugs for neutralizing skin irritation are, for example, allantoin, myrrhicol, bisabolol, Rudbeckia extract, and ubiquinol. μ Pharmaceutically acceptable polymer 122883.doc 200816981 A suitable pharmaceutically acceptable polymer is, for example, a cationic polymer having the INCI name polytetraammonium, for example, vinylpyrrolidone/N- Copolymer of ethylene-based miso salt (Luviquat FC, Luviquat HM, Luviquat MS, Luviquat &commat, Care), N-vinylpyrrolidone/methyl methacrylate quaternized by bismuth sulphate Acryl Ethyl Copolymer (Luviquat PQ 11), N-Ethyl Caprolactam Amine/N-Vinyl Ratio, Slightly S-S/N-Ethyl Taste, Cobalt Salt Copolymer (Luviquat E Hold), cationic cellulose derivatives (polytetra-ammonium 4 and polytetra-ammonium-10), acrylamide-based copolymers (polytetra-ammonium-7) and polyglucosamine. Suitable cationic (quaternary ammonium) polymers are also Merquat (polymers based on dimethyldiisopropylammonium hydride) and Gafquat (by polyethylpyrrolidone and quaternary ammonium compounds) The quaternary polymer produced by the reaction), the polymer JR (hydroxyethyl cellulose having a cationic group) and the cationic polymer based on a plant, such as a guar polymer, such as the Jaguar® grade from Rhodia. Other materials which can be used as polymers are neutral polymers such as polyethylene exoarridone, N-vinylpyrrolidone and copolymers of vinyl acetate and/or vinyl propionate, polyoxyalkylene, Polyvinyl caprolactam and other copolymers with N_vinylpyrrolidone, polyethyleneimine and its salts, polyvinylamine and its salts, cellulose derivatives, polyaspartate and derivatives . Such polymers include (for example, ^uviflex® 0 Swing (partially saponified copolymer of polyvinyl acetate and polyethylene glycol, BASF Aktiengesellschaft). Suitable polymers are also nonionic, water soluble or water dispersible polymers. Or oligomers such as, for example, Luviskol® 0 Plus (BASF) polyethylene 122883.doc -41 - 200816981 hexyl decylamine, or polyvinylpyrrolidone and especially with vinyl esters such as vinyl acetate a copolymer such as Luviskol 8 〇 va 37 (BASF), for example, a polyamine based on itaconic acid and an aliphatic diamine, as described, for example, in de_a_43 33 238. Suitable polymers are also amphoteric polymers or Zwitterionic polymers, such as octyl acrylamide/methyl methacrylate/tert-butylaminoethyl methacrylate/hydroxypropyl methacrylate commercially available under the name Amph〇me, (National Starch) And a zwitterionic polymer as disclosed in, for example, German Patent Application D]g 39 29 • 973, DE 21 50 557, DE 28 17 369 and DE 37 08 451. Acrylaminopropyl III Methyl _ ammonium chloride / acrylic or nail The acrylic copolymer and the alkali metal and its ammonium salt are preferred amphoteric ionic polymers. Other suitable zwitterionic polymers are commercially available as the methacryl oxime ethyl beet/methacrylic acid under the name Amersette^AMERCHOL) Ester copolymers, and hydroxyethyl methacrylate, decyl methacrylate, N,N-diamidoethyl methacrylate and copolymers of acrylic acid • (Jordapon(D)) ° Suitable polymers are also Nonionic, siloxane-containing, water-soluble or water-dispersible polymers such as polyether siloxanes such as Teg〇pren® 〇 (Goldschmidt) or Besi & commat (Wacker). Solid or liquid or mixtures thereof The expression solid or liquid or mixtures thereof is to be understood in a very broad sense. In principle, 'salt understanding, which means that in addition to antioxidants, mixtures (M1) and (M2), preparations, colorants, vesicles, carotenoid formulations, dermatological skin care products, pharmaceuticals, food and animal feed Any solid or liquid or mixture thereof that naturally occurs or can be synthesized to produce 122883.doc -42- 200816981. The natural source of the compound and the compound (v) itself are not included. Of these, it is preferred to include all commercial products. The product is first and foremost a basic product and a precursor product that can be used to produce a commercial product, and the commercial product itself. According to one of the preferred embodiments, the salt is understood to be included. According to another preferred embodiment, the salt, paint and other dyes are included. In another embodiment, the solid or liquid or mixture thereof is a solvent, a monomer, an oligomer, and a polymer. Other embodiments may be fuels and mineral oils. Embodiments can also be used to construct chemicals and building Φ materials. The examples are also agricultural chemicals such as crop protection compositions or fertilizers. In another embodiment, it is a dispersion and in another exemplary embodiment is a colored paper. Preparation of Compound (V) Compound (V) belongs to the class of substances of aromatic carotenoids. Carotenoids are widely distributed in nature and have high variability. Carotenoids are produced by many photosynthetically active organisms and a few photosynthetically inert organisms. The biochemical production route of the Φ-carotene-based structure has been fully studied and is the same for the large-mouth P-knives (Armstr〇ng, G., 1999, 〇11·R. Barton & K. Nakanishi, Comprehensive Natural products chemistry, vol. 2, 321-352). In the natural environment, 3,3'-dihydroxyisoxanthene is present in microorganisms such as Streptomyces mediolani or BRvibacterium linens. In the extended Brevibacterium, it is present along with its biochemical precursors (isoxenene and 3-hydroxyisoxenone) and is responsible for causing the bacteria to be yellowish red (K〇hl et al., 1983, 122883.doc-43). - 200816981

Phytochemistry 22, 207-210). Expanding Brevibacterium is also on red smudged cheese, such as Limburger, Miinster, Briek, Tilsiter and

The bacterial stains on the Appenzeller, the components of the composite composition, and which can be separated therefrom. In order to make the colonies containing 3,3'-dihydroxyisoxanthene easier to find, it is possible to use the facts of the reaction. Ionization of the resulting lanthanide ring produces a dark color effect which causes the color to change from yellow-orange to pinkish purple (Rattray, FP, , Fox, PF 1999, Journal of Dairy Science, 82, 891-909) 〇 3, 3'- Dihydroxyisoxanthene can be produced in a variety of ways. Preferably, separation has been performed from microorganisms to date. DE 18 08 514 A1 discloses a process for producing 3,3f-diisoisoxylene. In this method, a 3,3f-dihydroxyisosporous organism (Streptomyces melanosus) is produced and added to animal feed as a dried and ground cell powder. Alternatively, an extract of the organism containing 3,3 dioxyisoxanthine may be used. WO 2005/007826 A2 describes a process for the conversion of cyclic carotenoids to aryl-based carotenoids by biotransformation with the aid of them. To this end, a codon-optimized carotene desaturase gene is expressed in a Gram-negative host cell. Using this method, it is possible to produce isodecylene which can function as a precursor for the production of 3,3'-dihydroxyisoxylene in bacterial metabolism. A scientific publication has described the gene for cytochrome P450 monooxygenase from Brevibaeterium aurantiacum, whose gene product performs a high degree of biotransformation of isosporene to 3,3'-dihydroxyisoxanthene ( Dufoss 6, L et al, The last Step in the biosynthesis of aryl carotenoids in the cheese ripening bacteria 122883.doc -44- 200816981

Brevibacterium linens ATCC 9175 (Brevibacterium aurantiacum sp. Nov.) a a cytochrome P450 Mo no oxygenase, Food Research International, 2005, 38, 967-973) Alternatively, 3,3f-dihydroxyisoxanthene can be synthesized. Possible synthetic routes are described in the specifications EP 06116819.1 and EP 06116816.7. By oxidation, 3,3'-dihydroxyisoxanthene can be converted to blue isofapyrene-3,3'-dioxene (II) (Nybraaten G·, Liaaen-Jensen S·, • Characterization of Phenolic Carotenoids, Acta Chemica Skandinavica, 1971, 25, 370-372). Therefore, it should be understood that the intermediate of the reaction, 3-hydroxyisoxanthene-3'-indole, may be present in 3,3'-dihydroxyisoxanthene or iso-saponene-3,3,-difluorene or a mixture thereof. . 2,2',4,4'·tetra-tert-butylisoxenene·3,3,_diindole (III) and 3,3'-dihydroxy-2,2,,4,4'-four The preparation of t-butylisocyanene (IV) is described by Markus Schmidt in the paper (University 〇f Dtisseldorf, 2001, page 35 et seq.). Antioxidants, mixtures (Ml) or (M2), formulations, colorants, vesicles, carotenoid formulations, dermatological skin care products, pharmaceuticals, food and animal feeds or solid or liquid or mixtures present in the present invention The compound (V) or a mixture thereof used in the preparation thereof, especially the 3,3,-dihydroxyisoxanthene used, may have been produced by the natural or modified metabolism of the organism 'either completely synthesized or partially synthesis. The metabolism of an organism can be engineered, for example, by special fermentation techniques such as biocatalysis or genetic engineering operations. 122883.doc -45- 200816981 Compound (v) is advantageously used in an enriched form and/or in pure form. Especially for the compound (1), this is especially true for the 3,3|-dihydroxyisoxanthene. It is understood that the enriched form herein means a concentration of a compound which is considered to be present in each case at a higher concentration than the individual compounds present therein, for example, in the natural source of Streptomyces meliloti or B. brevis. If a natural source of two or more compounds (V) is available, the concentration in each case relates to the natural source from which the compound (V) has been enriched. In the enriched form, the concentration is preferably 2χ, 3χ, 4χ, 5χ, 6χ, 7χ, 8χ, 9x \〇x 2〇x, 3〇χ, 4〇x, 5〇x, 6〇x, 70x, 80x, 9〇χ, 1〇〇χ or greater than l〇〇x. In pure form, the compound (V) is in the range of from 丄 to 丨 (9)% by weight, preferably from 1 Torr to 1% by weight, particularly preferably from 30 to 100% by weight, based on the total weight of the respective compounds. It is particularly preferably present in a purity of from 5 to 1% by weight and most preferably from 75 to 1 GG% by weight. It is especially preferred to use a purity of more than 75% by weight, preferably more than 9% by weight, particularly preferably more than 95% by weight based on the total weight of the individual crystals. /. Very particularly preferably more than % by weight of the crystals of the respective compounds (V). The compound (V) derived from a natural source or a mixture thereof may be present in a mixture with other carotenoids and phospholipids. For each of the compounds (V), the content of other types of carotenoids and phospholipids other than the compound (V) is preferably less than 95%, 90%, 80% based on the total weight of the specific compound. 70%, 60%, 50%, 40%, 30%, 2%, 1%, 5%, 1%, 0.5% or 〇·〇5% by weight. It is especially advantageously used with a low phospholipid content which can be roughly determined via the phosphorus content. In particular, for the compound 1228.3.doc-46-200816981 (V) used in the carotenoid formulation, the phosphorus content should be δ10' less than 2% by weight of the total carotenoid formulation. Advantageously, it is less than 1% by weight, preferably less than 5% by weight, particularly preferably less than 0.1% by weight, very particularly preferably less than 〇〇2% by weight 〇

In order to improve the solubility, color yield and/or resorbability of the compound (V), the compound (V) is preferably present in a micron-sized form, for example, as a dry powder. In the micronized form, the compound has a small particle size. Advantageously, the particle size is less than ίο μηι, preferably less than 5 μηι and particularly preferably less than 1 pm, and very particularly preferably less than 0·3 μπι. The half width of the particle size distribution is advantageously smaller than the particle size, preferably less than 60% of the particle size, particularly preferably less than 5% of the particle size and very particularly preferably less than 40% of the particle size. In another preferred embodiment, the compound (V) or the compound (ν) in micronized form is present in combination with a protective colloid, a coating, a mixture with a vitamin or a combination of such materials. The production of such dry powders is described, for example, in 〇〇 〇〇 65 193 Α 2, ΕΡ 〇 835 613 BUilW 〇 91 / 〇 6292 A1, wherein compound (7) can be similarly used for the other carotenoids described in the specification, Such as β'carotene or araxanthene. Preferably, the particle size is determined by laser-photon correlation spectroscopy of Chu.? Laser Light Scattering; Academic P^ss3 New Y0rk 1974. 3 Antioxidant The present invention contains at least an anti-oxidant of an exotic compound (1). According to the preferred embodiment, the antioxidant according to the present invention contains only the isosapphire compound (1). <<The preferred (4) 3,3,. diiso-synthesis sponge is used as the antioxidant according to the present invention. In the embodiment, the antioxidant 122. doc - 47 - 200816981 The antioxidant of the present invention may comprise one or more isospinene compounds (1). in

In another embodiment, in addition to the isospinene compound (1), one or more compounds (II) to (IV) may also be present in the antioxidant according to the present invention. According to another preferred embodiment, the antioxidant according to the present invention may additionally contain other substances in addition to the one or more isospinene compounds (1). For example, other antioxidant state peroxide decomposers, free radical decomposers or other carotenoids are advantageous. Among these, the antioxidants according to the present invention preferably comprise, for example, at least one isospinene compound (1) and isoxanthene-3'3 to 1 to 1 (η) or 2, 2', 4 , a mixture of 4'_tetra-tert-butylisoxenylene dioxime (), a mixture of scorpionfish (μ 1), or containing 3,-di-yl 2,2',4,4'- A mixture of tetra-t-butylisoxylene (IV) and at least one isospinene compound (I) or mixture (Mi) (Μ2). The antioxidant according to the present invention may be composed of one antioxidant component or two or more antioxidant components. The antioxidant component is the above-mentioned compound t (V), preferably dihydroxyisoxanthene, a mixture thereof and other substances such as other antioxidants, peroxide decomposers, radical decomposers, organic and inorganic solvents; By, fat or sputum. To prepare an antioxidant according to the present invention, the antioxidant component can be used in an enriched, pure, crystalline or micronized form. The antioxidant component can be present here in solid form = in a suitable solvent. Suitable solvents are, for example, organic or inorganic solvents or fatty acids, oils and waxes. Preferably, it is an organic or inorganic solvent, fat, oil and soil approved for dermatological skin care or medicinal use for human consumption or for animal consumption or for use in both of the above-mentioned &lt; jr W T . The antioxidants can be mixed in - or multiple steps. If at least one liquid anti-122883.doc -48 - 200816981 oxidizing agent component has been used, the antioxidant may be dried or retained as it is. The amount of the respective compound phase selected from the compound (V) relative to the other antioxidant component may vary depending on the amount of the antioxidant component and the intended use and desired properties of the aging agent. For example, it may be 0.01% by weight, 0.05% by weight, 1% by weight, 5 tongues 0/5 weight %, 10% by weight, 20% by weight, 30% by weight, 40, based on the total weight of the total weight % by weight, 〇 〇 〇 〇 / "% 60 、, 60% by weight, 70% by weight, 80% by weight, 90% by weight, 95%, Λ 里里 W% or 100% by weight. Other antioxidants The quantitative ratio of the components is also extremely variable and the other anti-oxidation

The composition of the chemical agent can be varied within the same range. The antioxidant according to the present invention can be used for preparing a mixture, a preparation, a coloring agent, a vesicle, a carotenoid-like formulation, a dermatological skin care product, a pharmaceutical, a food or animal feed, a gelatin capsule or other solid or liquid or In the method of the mixture. Mixtures (Ml) and (M2) The present invention is further provided, comprising at least _ different kinds of sea _ compounds (1) and • isosporene-3, 3, _ bis (11) or 2, 2, 4, 4 a mixture of tert-butylisoxenene-3,3'-dioxin (m) or a mixture of such substances, or 3,3'-dihydroxy-2,2,4,4,-tetra- a mixture of a third butyl isosynthesis (IV) and at least one isospinene compound (1) or a mixture (M1) (]^2). Preferably, the mixture (Ml) or (M2) contains 3,3,-dihydroxyisoxanthene as the isospinene compound (I). The mixture (M1) or (M2) according to the present invention may be composed of one mixture component or two or more mixture components. The components of the mixture are compound (V) 'preferably 3,3'-dihydroxyisoxanthene, a mixture thereof and others 122883.doc -49- 200816981 quality 'eg other antioxidants, peroxide decomposers, free Base decomposers, organic and inorganic solvents, oils, fats + Tianyue fat or wax. For the preparation of the mixture (M1)

Or (M2), the mixture component can be used in an enriched, pure, crystalline or micro-sized form. The components of the mixture may be present herein in solid form or in a suitable solvent. Suitable solvents are, for example, organic or inorganic solvents or fats, oils and waxes. Preferably, the organic or inorganic solvent, fat mixture component approved for dermatological skin care, medicinally approved for human consumption or for animal consumption or for such use may be in one step or in Mix in two or more steps. If at least one liquid mixture component has been used, the mixture (M1) or (M2) may be subsequently dried or retained as it is. The amount of each compound selected from the compound (V) relative to the other mixture components may vary depending on the amount of the mixture component and the intended use and desired properties of the mixture (M1) or (M2). It may, for example, be 〇〇1% by weight, 0.05% by weight, 1% by weight, 5% by weight, 1% by weight, 2% by weight, 30/°, 30% by weight, 40% by weight, based on the total weight. %, 50% by weight, 60% by weight, 7% by weight, 80% by weight, 90% by weight, 95% by weight of ❶/〇 or about 1% by weight. The quantitative ratios of other mixture components are also extremely variable and can vary within the same range for each of the other mixture components. The compound (V) and the mixture (M1) or (M2) are suitable for the preparation of a mixture in which the properties of the substance are to be actively combined and/or influenced. If, for example, in addition to high anti-oxidation effects, certain color effects are also taken into account, beryllium (for example) 3,3^ dihydroxyisoxanthene can also be combined with blue isoflavones _3,3 , a mixture of bismuth (II), or with red BHT-carotenoid (Iv) or 122883.doc -50 - 200816981 2,2',4,4,-tetra-tert-butylisoxenene- 3,3,_Secondary (m) or other isospinene compound (1) or other mixture of carotenoids or a mixture with a mixture of such substances. Due to the different coloration and high antioxidant effects, it is possible to prepare different mixtures (Ml) or (M2) with varying coloration and antioxidant effects. The mixture (Μ1) or (Μ2) can be used for many purposes and its composition must be suitable for a particular purpose. The composition via mixture (5)) or (M2) may have a positive effect not only on oxidation or coloration, but also, for example, also have a positive effect on the health properties, or may make the properties of the vesicles φ, for example Stability or coloration changes. The mixture (Μ1) or (Μ2) is suitable for the preparation of preparations, colorants, vesicles, carotenoid formulations, dermatological skin care products, pharmaceuticals, food or animal feeds, gelatin capsules or other solid or liquid or mixtures thereof. Formulations The formulations according to the invention may be in the form of an antioxidant, a mixture (Μ丨) or (M2), a colorant, a vesicle or a carotenoid formulation. In general, the formulation • contains typical ingredients of the formulation, although such ingredients will vary depending on the scope of application of the formulation. The preparations according to the invention may be in the form of a final mixture or a combination of the ingredients of the preparation which are mixed before use. Such combinations may comprise the ingredients of the preparation separated in each case or one or more ingredients of the preparation separated from the mixture of other ingredients. The ingredients of the formulation may be present in varying concentrations or in varying forms, e.g., in solid, liquid or gaseous form or as a powder, crystal or emulsion. Combinations are usually provided simultaneously with a description of how the formulation ingredients can be used advantageously and in what manner. These technical specifications also generally include information on which formulation ingredients can be used as a substitute or as a component of the formulation. 122883.doc • 51 - 200816981 a. Likewise, the technical description may include information about the formulation ingredients or how the combinations are used for different purposes. The medicinal ingredients may be added to the dermatological cans, individually or in combination with one or more of the formulation ingredients and a mixture of other substances such as a solvent, at the same time or at different times. (3), pharmaceuticals, food or animal feed, solids Or a liquid or a mixture thereof. Examples of such preparations are: nutrient concentrates or fragrances. It is understood that the 'I agent ingredient' means any compound or substance present in the preparation. Examples of such preparation ingredients are, for example, compounds (v), other types of carotenoids, other antioxidants, minerals, enzymes, vitamins, organic sputum, trace elements, vitamins, enzymes, amino acids, mineral substances. Or an adjuvant such as an emulsified H1 hydrazine, a stabilizer, a preservative, an anti-caking agent, a solvent or a flavor enhancer. The formulation ingredients may be present, for example, in the form of a liquid, dispersion, suspension or as a solid and in the same or different enrichment, neat, crystalline or micronized form. The choice of formulation ingredients is hereby subject to the selected field of use of the formulation. For dermatological skin care preparations or pharmaceutical preparations, the preparation ingredients may consist of all substances suitable for a skin medical skin care preparation or a pharmaceutical preparation. Formulations intended for use in food or animal feed may be comprised of a mixture of all substances or substances that are safe for human or animal nutrition and/or approved for human or animal nutrition. These materials may be of natural or synthetic origin. Examples of suitable representatives of such substance classes can be found in the respective current list of food additives in the European regulations, such as the currently valid EC Directive 95/2/EC. 122883.doc -52- 200816981 The ingredients of this cockroach preparation are added to the slash φ according to the selected field of use and the quantitative mixing ratio based on the root τ τ (4) m I, different properties and depending on the selected field of use. Applicable objects have been known to be familiar with this technology. The ingredients listed here are Xi Lu / ^ , P1r-rm , which are especially suitable for food and animal feed "but can also be used in dermatological skin care products, especially in compositions for oral, dental or denture care, or - And in medical products, the restrictions are that they are approved for such purposes.

In the case of K ^, in addition to normal food or animal feed and / or separated from normal food or animal feed, liquids, powders, bonds, capsules or suspensions may be applied to human or animal organisms regardless of food or animal feed. The form is administered to the special preparation. Suitable formulation ingredients are, for example, vitamins. What are the vitamins, vitamins, vitamins, vitamins, vitamins, vitamins, vitamins, vitamins, vitamins, vitamins, vitamins, vitamins, vitamins, vitamins, vitamins, vitamins, vitamins, vitamins, vitamins, vitamins And better. Yangkouzhi, a preparation for food and animal feed, may also contain one type or different phenotype enzymes. Examples which may be mentioned are: amylase, phytase, protease or invertase. Amino acids suitable as a component of the preparation are, for example, face acid, L-carnitine, L. glutamine, L_taurine, L_aspartic acid, L•glycine, and amidoxime DL propylamine, l-tryptophan, lysine, L-arginine, L-cysteine, L-leucine, DL-methionine, L-alanine, serine , L_threonine, L-citrulline, L-proline, L-histamine, L-isoleucine, L-ornithine or 1-proline. I22883.doc -53- 200816981 particularly preferred are essential amino acids such as isoleic acid, L-lysine, DL. methionine, DL phenylalanine, L-tryptophan and L, aminic acid And very particularly preferred is the amino acid of importance = L-isoamine, DL methionine or magnesium, calcium, phosphorus, iron or zinc or a physiologically compatible salt thereof. A suitable trace of 70 is: complex, iron, gas, moth, abundance, molybdenum, nickel, selenium, vanadium, zinc or tin or a physiologically compatible salt thereof. ,

Formic acid, propionic acid or milk The most suitable organic acids for use in food and animal feed are acids, lactic acid, acetic acid and citric acid, particularly preferably formic acid. Other possible preparations especially for food and animal feed

Enhancer. I understand that for the purpose of the present invention, ‘’D door 々曰 阳 。. A sensation enhancer means a naturally occurring or synthetically produced substance capable of improving or enhancing the flavor of food and animal feed. The flavor enhancer which can be used is also a fragrance which does not contain the compound (V). For example, mention may be made of: E 620 glutamic acid, E 621 monosodium oleate, E 622 monopotassium glutamate, E 623 diammonium phosphate, E 624 monoammonium glutamate, E 625 bran Magnesium amide, E 626 guanylic acid, E 627 oleic acid disodium, E 628 guanosine dipotassium, E 629 guanylate calcium, e 630 glucoside, E 631 glucosinolate disodium, e 632 meat Dipotassium glycinate, e 633 carnitonic acid di-, E 634 5-ribonucleotide mother, E 635 5-ribonucleotide disodium, e 640 glycine acid and E 6 50 zinc acetate. The E numbers listed below are the terms used in Guideline 95/2/EEC for food additives. 122883.doc -54- 200816981 Other antioxidants that can be used are (for example) ascorbic acid (vitamin c, E 300) 'L-ascorbate (E 301), L-ascorbate (E 302), ascorbyl palmitate ( E 304), butyl hydroxyanisole (] 532 〇), butyl hydroxy benzene (E 321), calcium - disodium _ EDTA (E 385), such as gallic acid propylene vinegar (E 310), no Octyl gallate (E 3 u), lauryl gallate (lauryl gallate) (E 3 12) gallate, isoascorbic acid (E 315), sodium erythorbate (E 316) ), lecithin (E 322), lactic acid (E 270), such as di-salt (E 45 0), tristearate (E 451), polyphosphate (E 452) polyphosphate 'sulphur dioxide ( E 220), sodium sulfite (E 221), sodium bisulfite (E 222), sodium disulfite (E 223), potassium sulfite (E 224), calcium sulfite (E 226), calcium hydrogen sulfite (E 227), heavy Potassium sulfite (E 228), selenium, such as alpha-tocopherol (E 307), gamma-tocopherol (E 308), δ-tocopherol (Ε 309) and all tocopherols of coenenol (vitamin ε, Ε 306), chlorination ΙΙ (Ε 512), citric acid (Ε 330), sodium citrate (Ε 331), carotenoids, vitamins Α and potassium citrate (Ε 332). Suitable vitamins are fat-soluble and water-soluble vitamins. The vitamins to be mentioned are (for example): vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cobalamin), vitamin C (ascorbic acid), vitamin H (biotin), folic acid and nicotine. Emulsifiers suitable for food and animal feed are, for example, the following: E 420 sorbitol, E 420ii sorbitol syrup, ε 421 mannitol, E 422 glycerin, E 431 polyoxyethylene (40) stearate , E 432 polyoxyethylene sorbitan monolaurate / polysorbate 20, E 433 polyoxyethylene sorbitan monooleate / polysorbate 80, E 434 polyoxyethylene 122883.doc - 55· 200816981 sorbitan monopalmitate/polysorbate 40, E 435 polyoxyethylene sorbitan monostearate/polysorbate 60, E 436 polyoxyethylene sorbitan tri-hard Fatty acid ester/polysorbate 65, E 440 pectin, E 440i pectin, E 440ii amidated pectin, E 442 phospholipid ammonium; E 444 sucrose acetate isobutyrate, e 445 derived from root resin Glyceride, E 450 diphosphate, disodium salt e 450i diphosphate, trisodium Ε 450 Π diphosphate, E 450 iii tetrasodium diphosphate, E 450 iv dipotassium dipotassium, E 450v tetrapotassium dibasinate, E 450vi Dicalcium diphosphate, E 45 0vii calcium dihydrogen diphosphate, E 451 triphosphate, E 451 i pentasodium triphosphate, E 451 ii triphosphate Pentapotassium, E 452 polyphosphate, E 452i sodium polyphosphate, E 452ii potassium polyphosphate, E 452iii sodium polyphosphate # bow, E 452iv polyphosphoric acid, E 460 cellulose, E 460i microcrystalline cellulose, E 460ii fiber Plain powder, E 461 methyl cellulose, E 463 hydroxypropyl cellulose, E 464 hydroxypropyl decyl cellulose, E 465 methyl ethyl cellulose, E 466 carboxymethyl cellulose, E 469 enzymatic hydrolysis Carboxymethylcellulose, sodium, potassium and calcium salts of E 470a fatty acids, magnesium salts of E 470b fatty acids, monoglycerides and diglycerides of E 471 fatty acids, monoglycerides of E 472a fatty acids and diglycerides Acetate, monoglyceride of E 472b fatty acid and lactic acid ester of diglyceride, monoglyceride of E 472c fatty acid, citric acid vinegar of diglyceride, glycerol glycerol of E 4 7 2 d fatty acid And diglyceride tartrate S, E 472e fatty acid monoglyceride and diglyceride monoethyl tartar tartrate and diterpene tartrate, E 472f fatty acid monoglyceride and diglyceride Mixed acetate and tartrate, sugar ester of E 473 fatty acid, E 474 glyceroglyceride, E 475 fat Acid polyglyceride, E 476 polyglycerol polyricinoleate, E 477 fatty acid propylene glycol 122883.doc -56- 200816981 ester, E 479 fatty acid monoglyceride and diglyceride thermal oxidation of the big oil , E 481 stearin-2-sodium lactate, E 482 stearin calcium lactate, E 483 stearate tartrate, E 491 sorbitan monostearate, E 492 sorbitan tristearate Ester, E 493 sorbitan monolaurate, E 494 sorbitan monooleate or E 495 sorbitan monopalmitate. For the purposes of the present invention, it is understood that stabilizers especially mean substances which maintain the consistency or composition of food and animal feed. The substance φ which can be used as a stabilizer is ascorbic acid (E 3 (10)), diethyldiphenylurea (E 927b), iron lactate II (E 5 85), iron gluconate (E 579), glyceride ( E 445), lecithin (E 322), metatartaric acid (E 353), pectin (E 440), sucrose-acetate _ isobutyrate (E 444) and tin chloride-Π (Ε 512). Preservatives are substances that extend their shelf life by protecting against dermatological skin care products, pharmaceuticals, foods and animal feeds from the harmful effects of microorganisms. Examples which may be mentioned are: E 200 sorbic acid, E 201 sodium sorbate, E φ 202 potassium sorbate, E 203 calcium sorbate, E 210 benzoic acid, E 211 sodium benzoate, E 212 potassium benzoate, E 213 Calcium benzoate, E 214 p-hydroxybenzoic acid ethyl ester / PHB ester, E 21 5 sodium p-hydroxybenzoate / PHB ethyl ester sodium salt, E 216 p-hydroxybenzoic acid propyl ester / PHB propyl ester, E 217 Sodium p-hydroxybenzoate/PHB propyl ester sodium salt, E 21 8 methylparaben/PHB methyl ester, E 219 methylparaben hydroxybenzoate/PHB methyl ester sodium salt, E 220 sulfur dioxide, E 221 Sodium sulfite, E 222 sodium hydrogen sulfite / sodium bisulfite, E 223 sodium metabisulfite / sodium disulfite, E 224 potassium sulfite / potassium sulfite, E 226 calcium sulfite, E 227 calcium hydrogen sulfite, E 228 hydrogen sulfite 122883 .doc -57- 200816981 Potassium / potassium bisulfite, E 230 biphenyl / diphenyl, e 231 o-phenylphenol, E 232 o-phenyl stearate, e 233 thiabendazole, e 234 nisin, E 235 natamycin, e 23 9 hexamethylenetetramine, e 242 dimethyl dicarbonate, e 249 potassium nitrite, E 250 sodium nitrite, E 251 sodium nitrate and E 252 potassium nitrate.

For the purposes of the present invention, an anti-caking agent is a naturally occurring or synthetically produced material which increases the flow of food or animal feed by preventing aggregation and adhesion of the particles. Anti-caking agents that can be used are, for example, E 53 magnesium oxide, E 5 3 5 sodium ferrocyanide, e-Ming, E 551 dioxide

536 potassium ferrocyanide, E 541 acid sodium phosphate, E 552 calcium citrate, E 553ai magnesium citrate, E

Magnesium sulphate (no asbestos), E 5 talc powder (no asbestos), E... sodium sulphate or E 556 stone yoghurt. In the embodiment, the preparation used in accordance with the present invention may comprise a polyviroic acid as a component of the preparation. Sound suppression, - 乂 this invention, salty understanding, aggregates... For, flow characteristics, water absorption capacity and storage properties of the product t^ refined sugar-based, &quot; body can be such as lactose or malt paste 々-,, coarse powder, wheat flour and soybean cedar grain or - plant products are mainly Baizhi - 夕A 禄 邻 邻 巧 銕 salt, sodium salt, potassium salt,,,, machine, and D_ D-pantothenate produced by pantothenic acid or its own yeast is dominant. The sub-production or the fine acid is in another embodiment 'based on a plurality of (4) components (5) (4), the use of one or the substance, that is, does not exhibit two = suitable carrier is "inert" carrier The substance of the interaction according to the components of the preparation of the invention, the carrier substance of course must be, for example, in food and 122883.doc • 58 · 200816981 organic: two: said to be safe. The agent substance is a low-molecular-weight inorganic or organic compound derived from a source, and a salt compound, which can be used as a carrier, a person who can act as a carrier, or an organic substance such as an organic substance in a 2 θ back knife. =, carbon sodium sulphate and sulfuric acid lock, tender or chopped stone or hurried, such as an emulsified Shi Xi, Shi Xi acid or Shi Xijiao. Suitable organic powder products. Relative high molecular sugar sugar and paste + Examples of organic carriers are: starch and cellulose

In particular, such as corn house flour, corn cob coarse powder, ground rice husk, semolina bran or cereal wheat flour, such as wheat, rye, barley and oat bran or dough and mixtures thereof. The weight fraction of the antioxidant, mixture (Ml) or (M2), colorant, vesicle or carotenoid formulation according to the invention according to the invention may vary over a wide range and Constrained by actual problems arising from selected application areas, such as for animal husbandry, livestock ownership or human nutrition. In an embodiment of the invention, the preparation suitable for the use according to the invention may comprise, for example, from 1 to 10% by weight, preferably from 1 to 2% by weight, particularly preferably from 20 to 30% by weight, especially Preferably, from 3 to 4% by weight of the anti-tanmation agent, mixture (Ml) or (M2), colorant, vesicle or carotenoid formulation. However, it is also possible to choose a higher weight percentage. The formulations according to the invention are prepared in the simplest case by mixing the individual components. The preparation can also be carried out by mixing a solution or dispersion of the ingredients of the preparation, and if appropriate, subsequently removing the solvent or dispersant. 122883.doc -59- 200816981 Mixtures of different ingredients can be present in any weight ratio. The simplest form of mixing is to bring together the ingredients of the formulation in a mixer. Such mixers are known to those skilled in the art, for example from Ruberg (vertical biaxial mixer (HM type (10-50 000 1)), ring_layer mixer granulator (RMG type), continuous construction Granulator dryer (HMTK type), vertical single-axis mixer (VM type (10-50 000 1)), container mixer (COM type (50-4000 1)). Other mixers are also available from (for example) Lddige, Dmis, Engelsmann. Mixers can be operated discontinuously or continuously. In a discontinuous I mixer, all of the ingredients of the formulation to be mixed are usually initially introduced at the desired ratio and then mixed for a sufficient time in the range of minutes to hours. The mixing time and the mixing stress are set so that the ingredients of the preparation are evenly distributed, that is, the individual preparation ingredients are evenly distributed in the preparation. In the case of continuous mixing, the ingredients of the preparation are continuously added, and if necessary, continuously added after premixing. In the device, the residence time and the mixed stress are selected such that the formulation components are present in the mixture in a uniform distribution. Compared with the case of discontinuous mixing, the mixing time in continuous conditions is often compared. And the stress is higher. The mixing is usually carried out at room temperature but can also be carried out at a higher or lower temperature depending on the substance used. The preparation may be present in liquid form, for example as a solution, dispersion, suspension, or as a solid. In a preferred embodiment, the formulation is in solid form. Depending on the requirements of the application, the formulation may be in the form of a powder having an average particle size in the range of 10 μπι to 5 000 μηη, preferably an average particle size in the range of 20 μπι to 1000 μηι. By average particle size it is meant herein that at least 75% of the particles have a particle size within the specified range. 122883.doc -60- 200816981 The resulting particle distribution of the powdered product is available from MaWern

Analysis in instruments from Instruments GmbH, Mastersizer S. The mixture may be mixed as a pure blend, i.e., the materials are mixed at a desired particle size and concentration ratio, and other formulation ingredients may be added as appropriate, wherein the material may also be protected by a coating if needed. In addition, it is possible to use the core-shell structure', i.e. one or more formulation ingredients, as the core, and one or more other formulation ingredients externally as the outer shell - or vice versa. If m' is required for these structures, other coatings are required. It is also conceivable to encapsulate the substances together in a common matrix of carrier materials or protective colloids. Examples thereof are known to those skilled in the art and are described, for example, in R.A. M.rten: Fat_Soluble vitamins, pergam〇n press, 1970, page 131 t0 145. The powder can be produced by crystallization, precipitation, drying, granulating or agglomerating methods known to those skilled in the art, or other methods for forming the solids described in the present text. Colorant The present invention further provides a coloring agent comprising the compound (V). The coloring agent according to the present invention may be composed only of a compound (V) such as 3,3'-dihydroxyisosapphire or dihydroxyisomethenyl-3-indole. It is also possible that it contains or consists of different compounds (V). Furthermore, it may comprise, or be prepared from, an antioxidant, a mixture (Μ 1) or (M2), a formulation, a vesicle or a carotenoid formulation according to the invention. In addition, it may contain other substances (colorant components) which are commonly used in colorants as is well known to those skilled in the art. The colorant component can be, for example, a dispersing agent or suspension 122883.doc-61-200816981 which contains other dyeing agents, rituals or fats, oils and waxes. Preferably and / or pigments, such as other carotenoids. For the preparation of the colorant, or in the colorant, the compound (V) is preferably particularly preferably in a pure form and very particularly preferably crystalline or micron. Or in the form of an aggregate of HslJ' or for the mixing of such substances to increase the stability of the colorant, preferably approved for human or internal or body and/or for dermatological skin care compatibility and

:::: Antioxidants, peroxide decomposers, free radicals or ceriums and oils can be used as coloring agents. The colorant can be used alone or in the presence of a protective colloid or comprise the specific protective colloid. Protective colloids are, for example, gelatin, fish gelatin, house powder, dextrin, vegetable protein, pectin, acacia, casein, casein tread or mixtures thereof. Other protective colloids are polyvinyl alcohol, polyethylene glycol bites: methyl cellulose, (iv) cellulose, propyl cellulose and salts. The nature of K wood can be positively affected by the addition of softeners. Softeners suitable for this purpose are, for example, sugars or sugar alcohols such as sugars, invert sugars, sorbitol, mannitol or glycerol. The amount of the protective colloid, the softening agent and the or the compound (v) or other colorant component, especially the other class of carotenoid, in the colorant is typically selected to obtain the final product, the final product comprising G.1 Between 1 and 10 ppm, preferably between 55 and 5G PPm, particularly preferably from 1 to 2. The above compound between PPm, 2G to 200 gram of protective colloid, 2 () to softener 122883.doc -62- 200816981 ^ as appropriate) a small amount of stabilizer. Quantitative data in each case relates to the coloration: the total quality of the sword, dermatological skin care product, pharmaceutical product, food and animal feed, or the total mass of the solid, liquid or mixture thereof. The colorant can be prepared by simple mixing. The colorant components may be added sequentially or simultaneously and mixed. May also be an antioxidant, a mixture (M1) or

(M2), the formulation, the liposome or the compound of the formula (V) in the form of a compound of the formula of the carotenoids, depending on the color effect desired in each case and the preparation of the coloring agent according to the present month Depending on the use. It also limits the type and amount of other colorant components. For example, for a coloring agent according to the present invention to be used for human or animal use, for example, for dermatological skin care products, pharmaceuticals, foods and animals (4), it is preferably suitable for such use and preferably Appropriate colorant ingredients for these applications are approved. The body has a high light fastness and is therefore particularly suitable for applications in which the highest possible light fastness for coloring is desired. The aggregate can be, for example, by mixing one or more of the compounds (v) with water, such as isopropanol, ethanol, acetone or tetrahydrofuran, as appropriate with other substances, preferably other carotenoids. The solution in a miscible organic solvent is prepared by mixing with water. When a suitable quantitative ratio of water to organic solvent is selected, ruthenium or j aggregates can be prepared. These aggregates are characterized by a high lightfastness, an aggregate exhibiting a "playing-card-like" stack of molecules, and a J-aggregate exhibiting a linear alignment similar to the head-to-tail linkage. In contrast to the bulk form, the ruthenium aggregate can be present in various forms from the uv/vis photocompound (v) depending on the solvent and temperature. In a preferred embodiment, the compound (v) is in the form of aggregates, preferably aggregated. The bulk form is present in the colorant. These aggregates are compared to the monomeric form.

122883.doc •63- 200816981 The light-colored moving absorption band in the spectrum is detected, and the j-aggregate is detected by dark motion. With reference to these differences in absorption, the aggregates can be distinguished and their quantitative ratios determined. Liposomes The present invention further provides aliquots comprising at least one compound, preferably 3,3,-diisoisoxylene. The vesicles may have been prepared using one or more of the compounds (V), mixtures (mi) or (M2) according to the invention and/or colorants, formulations or carotenoid formulations, and may be used in the preparation of anti-drugs. An oxidizing agent, a mixture (M1) or (M2), a coloring agent, a formulation, a carotenoid formulation, a dermatological side skin, a pharmaceutical, a food or animal feed, or a solid and a liquid or a mixture thereof. The type and amount of the compound (V) used and any other liposome components present are governed by the particular intended use of the vesicles. Needless to say, for the vesicles used in foods, different requirements apply than those used for the technical dispersion. If the vesicles are used in human or animal applications, such as for skin φ medical skin care products, pharmaceutical products or food and animal feed, they should only be used for human and/or animal consumption or approved for dermatological skin care products. Or other microlipid components of the pharmaceutical product. Substances and mixtures of substances suitable as other aliquots are, for example, rituals, dispersants, other carotenoids, other antioxidants, peroxygen decomposers, free radical decomposers, vitamins or polymers. The vesicles consist of hydrophobic spheres in a hydrophilic environment. The spheres may be homogeneous or consist of one or more hydrophobic layers that surround the hydrophilic core and may be separated from one another by a hydrophilic layer. Other vesicle components may be present in the aqueous layer or in the hydrophilic layer or in the hydrophobic or hydrophilic layer in the layer 122883.doc-64 - 200816981. Partially here is meant in part about the amount of viscous components and individual molecules. The vesicle component may also preferably or exclusively be located in one or more specific layers of the vesicles, meaning, for example, included only in its hydrophilic interior space or in one or more hydrophilic intermediate layers or It is possible to have one or more vesicles of the vesicle component of any combination of such materials. The aliquots according to the present invention can be prepared in a variety of ways known to those skilled in the art and using various methods known per se to those skilled in the art. The compound (v) may be present as a monomer, a dimer, a trimer, a tetramer in the vesicles or in the aggregates of 1! and :|. The ratio of individual monomers, dimers, trimers, tetramers, or H&amp;/or j aggregates depends on the temperature and composition of the particular compound and other parameters, such as the solvent or lipid phase, and is incorrectly Changed by this special factor. Thus, the ratio of monomeric, dimeric, dimeric, tetrameric or ruthenium and J aggregates to other monomers, dimers, trimers, tetramers or ruthenium and J aggregates may be specific to the compound Total weight, _ varies from 0 weight ❶ to 100 weight ❻/0. For example, the 3,3-dihydroxyisomethenone is present in the vesicles having a phospholipid layer, preferably in the phospholipid layer&apos; and preferably in the form of ruthenium aggregates. One option for preparing the vesicles is to combine one or more compounds (ν) in a mixture of one or more organic/aprotic solvents with a mixture of the lipids in one or more organic/aprotic solvents, and The mixture is then dried. The resulting film can be coated with a buffer solution, sonicated and then extruded/so that it is possible to produce vesicles of varying structure and size. The vesicles may here consist of one layer (single layer of vesicles) or two or two layers of 122883.doc-65-200816981 (multilayer vesicles). Carotenoid Formulations The present invention further provides a carotenoid-like formulation comprising one or more of compounds (v). In addition, carotenoid formulations contain typical components of the carotenoid formulation, which may vary depending on the field of application of the carotenoid formulation. The compound (v) or a mixture thereof may be present in the carotenoid formulation according to the antioxidant, the mixture (1^1) or (1^2) of the invention, the preparation according to the invention, the colorant or the vesicle form, Or used for its purposes

Preferably, the carotenoid formulation according to the present invention comprises 3,3|-dihydroxyisoxanthene, iso-saponene_3,3匕2醌 and 2,2,,4,4!_四_ The third butyl isocyanin-3,3'-diindole, especially preferably 3,3,-dihydroxyisoxanthene and 3,3-isosylisodecene_3_醌, especially Preferably, it is 3,3,-dihydroxyisoxanthene. Preferably, compound (v) is in the form of a rich formula (4), preferably in pure form, and very particularly preferably in crystalline form for the preparation of a carotenoid formulation according to the invention. The carotenoid formulation may comprise other carotenoid formulation ingredients that are preferably suitable for human or animal consumption. The component of the carotenoid formulation may, for example, comprise other antioxidants, other types of carotenoids, preferably natural carotene 1) such as beta·hu's tetracycline, lycopene or lutein, Indigo H-lutein, cryptoxanthin, α•capsin or β_capsin, capsaicin, lipophyllin, vitamins, compounds with coenzyme characteristics, such as “finch ketone or resveratrol Flavanoids 'amino acids, minerals, enzymes, components of garlic, garlic thiamine, glutathione and its purpose, such as GSH monomethyl 122883.doc -66- 200816981 vinegar, GSH dimethyl hydrazine, GSH monoacetic acid, GSH diacetic acid, or oil, fat or mash. Among the fats, fatty acids are advantageous, preferably unsaturated acids and especially preferably polyunsaturated fatty acids or mixtures thereof. Among them, physiologically approved oils are preferred. Compounds having coenzyme characteristics are, for example, choline chloride, carnitine, taurine, creatine, ubiquinone, s-methylmethionine or 8_Glandular methionine. The composition of garlic can be thiosulfate sulfonate, 8-allyl cysteine: sulfone, vinyl dithimate , garlic ene, garlic thiamine, such as phenylphosphine sulfide φ amine, furan thiamine, octathiol or thiomethamine. Polyunsaturated fatty acids constitute a group of fats and are (for example) linoleic acid, secondary Linoleic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid. Physiologically approved oils constitute a group of oils such as sesame oil, corn oil, cottonseed oil, soybean oil , peanut oil, medium-chain vegetable fatty acid and fish oil such as eucalyptus oil, round belly oil or oyster sauce. • Quantitative fraction of additional carotenoids in the carotenoid formulation is 0.01 to 40% by weight, preferably in the range of 〇1 to 3% by weight, particularly preferably in the range of 0.5 to 20 〇/〇. Other types of fragrant ingredients can be, for example, protective colloids, softening Agent, emulsifier or a mixture thereof. The ratio of protective colloid and softener to carotenoid is usually selected so that the formulation obtained as the final product contains 1 () to 5 ()% by weight in addition to the above-mentioned class of cucurbitin Protective colloid, ^ to 70% by weight of softener and a minor amount of a stabilizer such as another anti-agent. The weight percentage is in each case based on the dry mass of the carotenoid = 122883.doc -67 - 200816981. Compound (v) or The mixture may be present as a component in the carotenoid formulation according to the present invention in a large or low quantitative fraction. If it is present at a high quantitative fraction, it may, for example, be used as a cytoprotective food supplement. If it is present at a low quantitative fraction, it may, for example, protect other components of the formulation from oxidation reactions. The amount of individual components of the carotenoid formulation according to the present invention may be formulated as a nutrient-like compound. For the purpose of the substance, it varies widely. Generally, the quantitative fraction of each component is in the range of G.G5 to (10)% by weight based on the total weight of the humectin-like formulation. If β-carotene, crocetin or lutein is present in the carotenoid formulation, the quantitative fraction of the compound (V) should be significantly different from β-carotenoid, Fanyou in each case. The fraction of red pigment or lutein. Significantly different herein means at least 1 G%, preferably at least 鸠, especially preferably at least 30% and very particularly preferably at least peach, or less than the maximum or minimum quantitative fraction of μβϋ素素素 or lutein. At least 1 (%), preferably at least 鸠, particularly preferably at least 3 G% and very particularly preferably at least qing. Quantitative fraction. The carotenoid-like formulation may be present in liquid or solid form. Preferably, it is located in gelatin&apos; especially preferably in a soft gelatin capsule. The preparation of such gelatin or capsules is known to those skilled in the art or can be carried out according to methods known per se to the person skilled in the art. Dermatological Skin Care The present invention further provides a dermatological L laminar mouthwash comprising a compound according to the present invention as an antioxidant, a mixture (μι) or a (Μ2)1 chromogen, a vesicle or a carotenoid-like formulation. Medium or more f 122883.doc -68- 200816981 or have been used to prepare. The dermatological skin care product according to the invention may be of a variable type. Salty, it particularly means different types of skin cosmetics, skin compositions and hygienic compositions. Dermatological skin care products can be, for example, w/〇 or 〇/w skin and body creams, day creams and night creams, eye creams, photoprotective compositions, after-sun products, hand products, face creams, multiple lotions, lips Glee, microemulsion, liposome preparation, sub-microsphere preparation, anti-wrinkle cream, face oil, micro-fat glue, sports gel, moisturizing cream, bleaching cream, vitamin cream, skin lotion, care _ wash d After the bottle repairing, preshave, moisturizing lotion, tanning lotion, body cream, decolorizing composition, massage preparation, body powder, facial tonic, mask, deodorant, inhibiting A sweat, nose strip, anti-acne composition, repellent, shaving composition, depilatory composition, intimate care composition, foot care composition or baby care composition. Preferably the 'dermatological skin care formulation is in the form of an ointment, cream, hydrogel, paste or paste, and a liquid such as a solution, an emulsion, especially an oil-in-water φ emulsion, such as a suspension of lotion The form of the drug. Liposomes or microspheres can also be used if desired. However, it may also be in the form of a clean skin and/or hair: solid stick, aerosol, spray (pump spray or aerosol), foam, 'gel, gel spray, lotion, cream , mousse, soft lean, suspension or powder or oily system or surfactant formulation. Other forms of dermatological skin care preparations for cleansing the skin and hair may be, for example, bar soap, toilet soap, cheese soap, transparent soap, luxurious soap, deodorizing soap, facial cleanser, baby soap, skin care soap, Scrubbing soap, synthetic detergent, liquid soap, paste soap, soft soap, washing paste, liquid washing, shower and bath. 122883.doc • 69 - 200816981, such as detergent, shower, shower gel, foam bath, milk Frost Foam Valley / from Lo, Valley extracts, rinse preparations, in-situ products, shaving foam, shaving lotion or shaving cream. For the purposes of this description, dermatological skin care products also include constitutive products, hair dyes or hair care compositions in cosmetics, preparations and perfumes for oral care, dental care or denture care. Dermatological skin care products can be advantageously used to treat cosmetic or skin modifications such as skin aging, skin moisture loss, skin elasticity loss,

Skin folds, formation of wrinkles or formation of pigmented or senile plaques. In addition, it can be used to treat or prevent the appearance of the skin* when it changes, such as acne or oily skin, keratinous products, rose or photosensitivity, #inflammatory, erythema, allergic or autoimmune response and the like. Preferably, the antioxidant or mixture according to the present invention is used in dermatological skin care products to restore and/or resurrect the skin. However, the dermatological skin care product according to the present invention is also used for soothing sensitivity and prolonged and irritating skin for the prophylactic regulation of collagen, hyaluronate, impeachment, synthesis of protein, stimulation DNA synthesis regulates the transcription and translation of matrix-degrading enzymes, especially in the presence of defective or unrestricted skin conditions. The transcription and translation of matrix metalloproteinases (MMPs) in the scorpion scorpion increases cell renewal And skin regeneration, increasing the skin's own DNA, lipids and / or human I mussel protection and repair mechanisms. Therefore, it should be noted that, for example, the hydration state and/or elasticity of the skin is altered. In addition, dermatological skin care ±哥 ± &quot; 餍 餍 can be used to clean the skin or hair or both. Preferably, it is in the form of a liquid or solid, &lt;stere&quot;, and preferably comprises, in addition to the antioxidant or mixture according to the invention, an anionic, nonionic or 122883.doc-70-200816981 amphoteric surface. Active substances or mixtures thereof, @ required - or a variety of electrolytes and auxiliaries. The extravagant surface is included in the total amount of the airborne agent at 1 and 94% by weight of nw. The concentration between the present is in the cleansing preparation. Skin medical skin care products are not just prescriptions. The sound is too . ^ &amp; Skin preparation "King. Salty understanding" Skin preparation means an agent for the treatment of a skin condition for preventing skin disease (dermatosis). The skin preparation can be associated with an individual or several causal associations such as an abnormality of the skin or a condition of medical abnormality.

In the preparation according to the invention, individual active ingredients and auxiliary ingredients and combinations of adjuvants may be present. It is especially suitable for the use of 洚淼馐p for the treatment of v. The dermatological skin care product according to the present invention may comprise active ingredients and auxiliaries such as preservatives, bactericides, essential oils, substances for preventing foaming, such as dermatological skin care products conventionally used in such preparations, Dyestuffs, coloring pigments, thickeners, moisturizing substances and/or moisturizing substances, fats, oils, waxes, vital nourishing agents, surface active substances, emulsifiers, softening substances or other dermal medical skin care formulations Ingredients such as alcohols, polyols, polymers, bead stabilizers, electrolytes, organic solvents, cosolvents, organic acids or polyoxo derivatives. In addition to one or more compounds (V), the dermatological skin care product may further comprise an antioxidant, a mixture (Ml) or (M2), a formulation, a colorant, a vesicle or a carotenoid formulation according to the invention and any skin. The active ingredient of the medical skin care product and the auxiliaries present, other substances which have osmotic properties and thus allow rapid absorption into the skin. On the other hand, for the characteristics of having, pre-adjustment, 122883.doc -71 - 200816981: force: the speed of penetration is usually not important, and the force of accumulating the storage in the skin is advantageous. Active ingredients and auxiliaries of dermatological skin care products = In some cases, dermatological skin care products may also contain at least one other soil, and the other components of MT - active ingredients: anti-fungal agents, preservatives, antibiotics, continuation Amines, disinfectants, corticosteroids, leaf oils and tar saponins: astringents, antiperspirants, anti-acne, psoriasis, seborrhea and itching or stratum corneum separation.

To prepare a dermatological skin care product according to the present invention, dermatological skin care. The active ingredients and adjuvants may be mixed or diluted with suitable excipients. Form 2 is a solid or a more or less liquid substance which can be used as the active ingredient (iv), carrier or medium. Mixtures of other dermatological skin care active ingredients and adjuvants, where appropriate, are carried out in a manner known to those skilled in the art. In addition to the active ingredients and auxiliaries of dermatological skin care products, dermatological skin care products may also contain other compounds that have the effect of destroying free radicals and destroying the peroxides and anti-spot m anti-(four) effects to supplement or enhance Its role. In particular, the compounds may be selected from the group consisting of vitamins, plant extracts, alpha-carboxylic acids and carboxylic acids, neuroketamines, anti-inflammatory agents, anti-rigid agents or occupational substances, selected from the group consisting of Ethoxylated glycerol, ethoxylated oil, emulsifier, surfactant, preservative, essential oil, _, hair polymer, hair and skin conditioner, graft polymer , water-soluble or water-dispersible poly-stone polymer, sorbitan ester, photoprotectant, bleach, gelling agent, care agent, two-component, coloring agent, tincture, dye, pigment, consistency Conditioner, moisturizing II, 122883.doc '72- 200816981 fatliquor, collagen 'protein hydrolysate, lipid, antioxidant, antifoaming agent, antistatic agent, emollient and softener, glidant, wetting agent , emulsifiers and suspending agents, preservatives, anti-irritant substances, chelating agents, emulsion stabilizers, film formers, gelling agents, odor masking agents, resins, hydrocolloids, solvents, solubilizers, neutralizers, Penetration enhancer, pigment, quaternary ammonium compound, fatliquor and fat , Ointment, cream or oil-based substances, polyethylene oxide derivatives of silicon, stabilizing agents, sterilizing agents, propellants, drying agents, opacifiers, thickeners, waxes, softeners, white oils. In this regard, an embodiment is based on, for example, φ expressed in, for example, Fiedler, Η·Ρ·Lexikon der Hilfsstoffe fiir Pharmazie, Kosmetik and angrenzende Gebiete [Lexikon of auxiliaries for pharmacy,cosmetics and related fields], 4th edition, Aulendorf: Expertise in ECV-Edition-Kantor-Verlag, 1996. In addition, the active ingredient and adjuvant may be selected from the group consisting of natural or synthetic polymers, pigments, humectants, oils, waxes, enzymes, minerals, dyes, fragrances and derivatives thereof, and mixtures thereof . • According to the invention, the polysorbate is advantageously present in a concentration of from 0.1 to 5% by weight and especially from 15 to 2.5 % by weight, based on the total weight of the composition, individually or as two or more A mixture of polysorbates is used. In addition to the antioxidants according to the present invention, dermatological skin care products may also contain other antioxidants. The amount of the other antioxidant (one or more compounds) in the skin and the skin is preferably from 0.001 to 30 liters/°, more preferably from 5% to 2% by weight based on the total weight of the preparation. Especially for work to (7) weight. The right vitamin and/or its derivatives are other antioxidants, and are advantageously selected from the total weight of the dermatological skin care preparation, from 1 to 1 weight, 0/〇122883.doc • 73-200816981. Their respective concentrations. If the vitamin A or vitamin A derivative or other carotenoid or its derivative is an antioxidant, it is advantageously selected from the total weight of the skin care product, from 1 to 1% by weight of the skin. Their respective concentrations. In one embodiment, an antioxidant, a mixture (Ml) or (M2), a formulation, a colorant, a vesicle or a carotenoid formulation according to the invention or an antioxidant, a mixture prepared according to the process according to the invention ( Ml) or (M2), system 4, colorant, vesicle or carotenoid formulation is at least one weight of from 0. 01 to 10% by weight, preferably from 5 to 5 by weight. /. The fractions are present in the composition together with the pellets of the composition. Suitable materials are, for example, those which are solid at room temperature (25C) and which are in the form of granules. Suitable are, for example, vermiculite, silicate, aluminate, clay, mica, especially salts of inorganic metal salts, metal oxides such as titanium dioxide, minerals and polymer particles. The granules are present in the composition in a non-cold and preferably stable dispersed form and can be precipitated as a solid upon application to the surface of the application and evaporation of the solvent. The U-grain is a stone salt of Shi Xishi (Shi Xijiao, Dioxite Xi) and a metal salt machine, and the cut stone is particularly preferred. The metal salt is, for example, a metal or soil metal such as sodium or chaotic potassium, or an alkali metal or alkaline earth metal sulfate such as sodium or magnesium sulfate. Dermatological skin care products can comprise a lipid phase and an aqueous phase. The lipid phase may advantageously be selected from the group consisting of mineral oils, minerals, triglycerides of citric acid or triglyceride of octanoic acid, and "oil, fat, earth and other natural and synthetic fats" Fatty acid and alcohol having a low carbon number, for example, vinegar with isopropyl 122883.doc -74-200816981 oil, or vinegar or fatty acid ester of fatty alcohol with a low carbon number alkanolic acid; benzoic acid Alkyl esters, anthrone oils, such as dimethyl polyoxime, diethyl polyoxoxime, diphenyl polyoxyl and combinations thereof. Liquor, oil gel or aqueous dispersion or lipid dispersion The oil phase of the liquid may advantageously be selected from the group consisting of saturated and/or unsaturated, branched and/or unbranched m-acids having a chain length of from 3 to 30 carbon atoms, selected from aromatic acid-lowering acids. And a group of esters of saturated and/or unsaturated, branched and/or unbranched alcohols having a chain length of from 3 to 3 carbon atoms. Preferred are vinegar oils from the group of the following: fourteen Sour ointment isopropyl vinegar, palmitic acid isopropyl vinegar, stearic acid isopropyl vinegar, oleic acid isopropyl vinegar, stearic acid n-butyl vinegar, lauric acid hexane vinegar, oleic acid , isodecyl stearate, isophthalic acid isophthalic acid vinegar, palmitic acid 2-ethylhexyl vinegar, 2-ethylhexyl laurate, 2-hexyl phthalic acid stearate, standard acid 2- octyl ten Dibasic vinegar, oleic acid oil _, erucic acid vinegar, oleic acid mustard vinegar, fenic acid mustard vinegar, and synthetic, semi-synthetic and natural mixtures of such vinegars, such as jojoba oil. a group selected from the group consisting of branched and unbranched hydrocarbons and hydrocarbon waxes, fluorenone φ oils, dialkyl ethers, saturated or unsaturated, branched or unbranched alcohols, and fatty acid triglycerides That is, a monoglyceride having (1) wei, to the saturated and/or unsaturated, branched and/or unbranched alkane I of the chain length of 18 carbon families. The fatty acid triglyceride can be, for example, Advantageously selected from the group consisting of: synthetic, semi-synthetic and natural oils such as olive oil to sunday oil, large oil, peanut oil, rapeseed oil, almond oil, oil, coconut oil, palm kernel oil Any mixture of such oils and wax components is also intended to be advantageously used for the purposes of the present invention. If appropriate, it may also be advantageous to produce, for example, palm I vinegar soil 122883.doc - 75· 200816981 As the sole lipid component of the oil phase. The oil phase is advantageously selected from the group of grains in the following categories: 2-ethylhexyl isostearate, s-quinone, iso-tridecyl isononanoate , isoicosane, 2-ethylhexyl cocoate:: C12-Cl5u formic acid, citric acid/capric acid triglyceride, diterpene C12-c15 alkyl ester, isostearyl 醆2_ethyl Mixtures of esters and isophthalic acid isophthalic acid vinegar are particularly advantageous. Among the smokes, 'stone bad oils, angles U and horns are advantageously used for the purposes of the present invention. In addition, the oil phase may advantageously have The content of the cyclic or linear chain oil is or consists entirely of the oil, although it is preferred to use an additional amount of other oil phase components other than the or the oleic acid oil. Octamethylcyclotetracycline is advantageously used as the oil to be used in accordance with the present invention. However, other oleanin oils such as hexamethylcyclotrioxane, polydimethyl oxalate, and poly(methylphenyl oxynphthene) are also desirably used for the purpose of the present invention. Mixtures of broad-spectrum polyoxaxane and isodecyl isononanoate, and mixtures of cyclomethicone and isostearic acid 2·ethylhexan are particularly advantageous. The aqueous phase of the dermatological skin care product according to the invention advantageously comprises, in each case, an alcohol, a diol or a polyol having a low carbon number, if appropriate, or in combination, and an ether thereof, preferably ethanol. Isopropanol, propylene glycol, glycerin, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl, diethylene: alcohol monomethyl or monoethyl (tetra) similar The product, and especially the one or more may be advantageously selected from the group consisting of a group of dioxobic acid, a dream acid, a poly 122883.doc-76-200816981 sugar or a thickening agent thereof, such as a hyaluronic acid, a trisin, Hydroxypropyl methylcellulose is particularly advantageously selected from the group of polyacrylates, preferably polyacrylates from the so-called polyethylidene group, such as polycarbene 98 (), 981, 1382, 2984, 5984 level. / Tongue components and auxiliaries may also be described in the patent or patent application EP 00974775 B1 ^ DE 23 11 712 &gt; EP 02 78 878 &gt; DE 19 99 47 147 &gt; EP 0706822 B1 &amp; W0 98/16621 Encapsulated forms are present in the formulations according to the invention, which are expressly incorporated herein by reference. If necessary, more dermatological skin care active ingredients and auxiliaries can be blended together. However, it can also be processed separately and then combined.

The formulation base of the dermatological skin care product according to the present invention preferably comprises one or more cosmetically compatible vehicles, cosmetically compatible materials and possibly pharmaceutically acceptable active ingredients and adjuvants. It is known that the active ingredients and auxiliaries used in the fields of pharmacy, food technology and related fields are pharmaceutically acceptable 'especially listed in the relevant pharmacopoeia (for example, listed in DAB Ph. Eui\ BP NP) Their active ingredients and auxiliaries, and their properties do not exclude other active ingredients and auxiliaries for physiological applications. Dermatological skin care products are preferably used in individuals, preferably mammals, especially humans, beneficial animals or domestic animals. It is applied in a manner customary for a particular formulation. Here, dermatological skin care products are usually applied in a sufficiently effective amount and are preferably percutaneous (topical) applications. According to a preferred embodiment, the application of the dermatological skin care product according to the invention is carried out by regular application over a period of time. It is subject to the desired goal ^ 122883.doc -77- 200816981, that is, if the target is for the life of the skin sound user, it is better to extend the ": deposit" period can be continued ^ person 1 and then the performance of two up to 3 For the period of the month, it is particularly preferable to adjust the enthalpy. For post-mouth applications, the application for the purpose of the present invention is early: human application, but preferably at least 1 day, especially preferably for 3 days η Months, especially preferably for a period of 1 to 2 weeks. . : According to the anti-emulsifier or mixture (Ml) or (M2), preparation, granulation or carotenoid formulation of this month, it can help on the one hand. :

: hair: a skin or customary agent caused by a catalyzed or exogenous oxidative process: another aspect protects the oxidatively sensitive substance and is therefore stable here as an antioxidant 根据 根据 according to the invention having no other identical composition ^ ° The root of the substance, the chromophore, the vesicle or the carotenoid-like formulation: a concentration of the same concentration and the same stress, the formulation is used twice or to prevent or reduce due to, for example, photoinduced oxidation Damage-induced light sensitivity and/or oxidative sensitivity The ability of the dermatological skin care active ingredient or force d or other components of the dermatological skin care product to decay or inactivate. The dermatological skin care product according to the present invention usually comprises, based on the total weight of the dermatological skin care product, ❹ (四)% by weight, preferably. .01重量; %, especially preferably 0_05 to 5 weight 4%, very particularly preferably 〇1 to 2% by weight of the antioxidant, mixture (Ml) or (M2), formulation, colorant, lipoic acid according to the invention Granule or carotenoid formulation. If the field is based on the antioxidant, mixture (μ 1) or the method of the invention, the colorant, the vesicle or the carotenoid formulation is combined with other active ingredients and auxiliaries in an encapsulated form, for example It is used in gelatin in the form of fibrin 122883.doc -78-200816981 2 encapsulation with polypamine for submicrospheres, with cyclodextrin, or by lipid encapsulation. Further, the present invention relates to the above-mentioned anti-articles (M1) or (M2), preparations, colorants 郃, mixed 1 曰 或 or carotenoids or according to the method according to the invention. Oxidizer, mixture (5)) or

Use of (M2), formulation, colorant, vesicle or porphyrin-like formulation in :: Skincare::. Preferably, the antioxidant, the chromogen, the vesicle or the porphyrin-like formulation according to the invention or the antioxidant, mixture, colorant, vesicle or the preparation according to the method of the present P or The carotenoid formulation is used in combination with (1) cosmetics from the decorative cosmetics field (9) dermatological skin care active ingredients and (iv) suitable auxiliaries and additives. These materials are preferably used to protect the skin, hair and/or fingernails and toenails from damage and are used to treat existing damage to the skin, hair and/or hands, nails and toenails and to care for the skin, hair and/or Or the active ingredients or auxiliaries and additives of nails and toes. Preferably, the active ingredients are selected from the group consisting of natural or synthetic polymers, pigments, humectants, oils, butterflies, enzymes, minerals, vitamins, sunscreens, dyes, fragrances, antioxidants, preservatives, and / or medicinal active ingredients. The above-mentioned antioxidant, mixture (Ml) or (M2), sputum, colorant, vesicle or carotenoid formulation according to the invention or antioxidant, mixture (M1) or (in accordance with the method according to the invention) M2), preparation, coloring, micro-moon granules or carotenoid formulations are preferably used for skin anti-mite compositions for decorative cosmetics, skin care compositions, skin cleansing compositions, hair and care compositions, hair care a composition, a hair cleansing composition, a hair dye or a preparation of 122883.doc -79-200816981, depending on the field of application, preferably in the form of an ointment, a cream, an emulsion, a suspension, a lotion, as a cream, a paste, Gels, Foams or Sprays to Use 0 Suitable auxiliaries and additives for the preparation of hair cosmetic or dermocosmetic formulations are known to those skilled in the art and can be found in cosmetic handbooks, for example in Schrader, Grundlagen and Rezepturen der Kosmetika.

[Fundamentals and formulations of cosmetics], Hiithig Verlag, Heidelberg, 1989, ISBN 3-7785-1491-1, or in Umbach, Kosmetik: Entwicklung, Herstellung and Anwendung kosmetischer Mittel [Cosmetics: Development, production and use of cosmetic c〇 Mp〇siti〇ns], 2nd Extended Edition, 1995,

Georg Tlueme Verlag, ISBN 3 13 712602 9 in. Preferred as 'an antioxidant, a mixture (M1) or (M2), a colorant, a vesicle or a carotenoid-like formulation according to the invention or an antioxidant, a mixture prepared according to the process according to the invention (Ml) or (M2), a formulation, a colored d-lipid or carotenoid formulation, and at least one component selected from the group consisting of: a component different from the following for use in a dermatological skin care product: Ritualizers, surfactants, preservatives, essential oils, thickening 剡: hair polymer, hair and skin conditioner, graft polymer, water-soluble 5, can be smuggled, bio-polymerized polyoxyl polymer, medicine Acceptable polymer brightening agent, bleach, gelling agent, care agent, coloring agent, coating agent, tincture, dye, pigment, consistency adjuster, moisturizer, fatliquoring::, collagen Protein, protein hydrolysate, fat! , antioxidants, defoaming 'antistatic agents, emollients and softeners. 122883.doc *80· 200816981 According to the invention, the antioxidant according to the invention, the mixture (5)) or _, the formulation, the coloring agent, the vesicle or the carotenoid formulation or according to the method of the present month Antioxidants, mixtures (10)) or ((10)), tinted, vesicles or carotenoid formulations are also used in combination with photoprotecting agents in dermatological skin care products. Such dermatological skin care photoprotective compositions are used for cosmetic and/or dermatological photoprotection, as well as for the treatment and care of the skin and/or hair and as a constitutive product in decorative cosmetics. Such substances include, for example, sunscreen, sunscreen lotion, sunscreen lotion, sunscreen lotion, __ sesame oil, sunscreen gel, lip care and lip balm, concealer and concealer stick, moisturizing cream, moisturizing lotion, moisturizing Emulsions, creams, body creams and hand creams, hair: therapeutics and rinses, hair styling compositions, styling gels, hair sprays, deodorant roll_ons or wrinkle creams, heat treatments, sunscreens Formulation or after-sun preparation. Sunscreens are mainly a mixture of various oils and/or a variety of photoprotective agents and essential oils. The oil component is selected based on varying cosmetic properties. An oil that will be applied to the skin and conveys the sensation of the skin, such as mineral oil such as stone oil and fat I diglyceride such as peanut oil, sesame oil, avocado oil, medium-chain triglyceride, and modified sunscreen The spread of oil and the absorption of sunscreen into the skin, reducing the viscosity and allowing the oil film to mix through the air and water vapor (sweat) oil. Such oils include branched fatty acid esters (e.g., isopropyl palmitate) and anthrone oils (e.g., dimethylpolyoxyl). When an oil mainly composed of an unsaturated fatty acid is used, an antioxidant according to the present invention or other antioxidant such as tocopherol is added to prevent rancidity. Sunscreens as anhydrous formulations usually do not contain a preservative. Sunscreen lotions and sunscreens are prepared in the form of an oil-in-water (〇/w) emulsion and oil 122883.doc 81 200816981 in water (w/o) emulsion. The nature of the formulation varies significantly depending on the type of emulsion. The 0/W emulsion can be easily applied to the skin, and in most cases it absorbs quickly and can be washed almost completely with water. The w/0 emulsion is more difficult to rub, which to a large extent greasy skin and thus has a slightly higher viscosity&apos; but on the other hand better protects the skin from drying out. The w/0 emulsion is mainly water resistant. In the case of a 0/W emulsion, the choice of emulsion base, suitable photoprotective materials and, where appropriate, auxiliaries (e.g., polymers) determine the degree of water resistance. The matrix of liquid and cream 0/w emulsions is similar in composition to the other emulsions that mussels use in skin care. Sunscreen lotion should be enough to make the skin dry due to sun, water and wind. It does not have to be viscous because it feels particularly unpleasant when it is hot and after contact with sand. Photoprotective agents are typically constructed based on a carrier comprising at least one oil phase. However, compositions based solely on aqueous solutions are also possible. Therefore, oil, oil-in-water and water-in-oil emulsions, creams and creams, lip balm blocks or grease-free gels are suitable. Suitable emulsions are, in particular, 0/w macroemulsions, 0/W microemulsions or 0/w/〇 emulsions having surface-coated, titanium dioxide particles present in dispersed form, which may be obtained by DE-A- The phase change technology of 197 26 121 was obtained. Conventional cosmetic auxiliaries which can be suitably used as additives are, for example, (auxiliary) emulsified sodium, fat and bad, stabilizers, thickeners, active ingredients of biological origin, film formers, fragrances, dyes, pearlizing agents, antiseptic Agents, pigments, electrolytes (such as magnesium sulfate) and pH adjusters. Stabilizers which can be used are metal salts of fatty acids such as magnesium stearate, aluminum stearate and/or zinc stearate. Salty, biologically active ingredients mean, for example, plant extracts, protein water, and vitamin complexes. Conventional film formers are, for example, hydrocolloids: polyglucosamine, microcrystalline polyglucosamine or quaternized ammonium polyglycosides, d-pyrrolidone, vinyl pyrrolidone-vinyl acetate Copolymer, 1 acid polymer, quaternary cellulose derivative and the like. Suitable optical filter active ingredients are those which absorb radiation in the range of UV_B&amp;/or uv_A. It is understood that these substances mean that they can absorb ultraviolet rays and re-ignite in the form of longer-wave radiation, for example, releasing the absorbed organic matter of θ in the form of heat. The organic material can be oil soluble or water soluble. Suitable uv filters are, for example, 2,4,6-triaryltriazinyl' alkoxy groups, in which the aryl group may have at least one substituent selected from the group consisting of the following groups, in particular It is a methoxy group, a silk group, especially a methoxy group and an ethoxycarbonyl group. Other suitable are p-aminobenzoic acid hydrazine, cinnamate, diphenylmethyl, camphor derivatives, and pigments which terminate uv rays such as titanium dioxide, talc and zinc oxide. It is especially preferably a pigment based on titanium dioxide. # Oil-soluble UV-Β filter that can be used is, for example, the following: 3_benzylidene camphor and its derivatives, such as 3-(4-methylheptylidene) camphor; 'aminobenzoic acid derivatives Preferred is 2-(2-didecylamino)benzoic acid 2-ethyl=ester, 4-(dimethylamino)benzoic acid 2·octyl ester and amyl (dimethylamino)benzoic acid; An ester of cinnamic acid, preferably 4-methoxyhexyl methoxycinnamate, propyl methoxy cinnamate, isoamyl 4-methoxycinnamate, 4-methoxy mash Isoamyl ester, 2-cyano-3-phenyl cinnamate 2-ethylhexyl ester (octocrylene); 122883.doc -83 - 200816981 Ester of salicylic acid, preferably water yang Acid 2-ethylhexyl ester, salicylic acid 4-isopropyl V, salicylic acid salicylate; benzophenone derivative, preferably 2-carbyl-4- Methoxybenzophenone, 2-hydroxy-4-decyloxy-4'-methylbenzophenone, 2,2,-dihydroxy-4-decyloxy, a formazan; a diacid, preferably 4·methoxybenzylidene malonic acid 2-ethylhexyl ester; a diterpene derivative such as 2,4,6-triphenylamine (pair Carbonyl-2,-ethylhexyloxy-yl)_1,3,5-triazine (octyltriazinone) and dioctylbutyryltriazinone (Uvasorb^HEB): propane-1,3- Diketones such as "(4·t-butylphenyl)&gt;3_(4,-methoxyphenyl)propan-1,3·dione. Suitable water-soluble substances are: 2-phenylbenzone Imidazole _5-sulfonic acid and its alkali metal salt, alkaline earth metal salt, ammonium salt, alkyl ammonium salt, alkanolammonium salt and glucoside salt; sulfonic acid derivative of φ benzophenone, preferably 2- Hydroxy-4-methoxybenzophenone-5-sulfonic acid and its salts; 3. benzyl sulfonic acid derivatives of camphor, such as 4-(2-o-oxy-3-indolylmethyl) Benzoic acid and 2-methyl-5-(2-sideoxy-3)-reduced acid and its salt 0 are particularly preferably used in the form of cinnamic acid, preferably 4-methoxycinnamic acid 2 _Ethyl hexanoic acid, 4-methoxy cinnamic acid isoamyl, 2_ aryl phenyl cinnamic acid 2 · ethylhexyl ester (Octolide). In addition, benzophenone is used in ruthenium Street creatures, especially 〕- 经基冰甲122883.doc •84· 200816981 oxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'- two 4-methoxybenzophenone, and using propane such as 1-(4-t-butylphenyl)-3-(4'-methoxyphenyl)propane-1,3-dione -1,3-dione. Suitable as a typical UV-A filter: a derivative of benzamidine methane such as 1-(4f_t-butylphenyl)-3-(4'.methoxy) Phenyl)propane-1,3-dione, 4-t-butyl-4'-nonyloxybenzylidene methane or 1-phenylisopropylphenyl)propane-1,3-dione; An amine-based hydroxy-substituted derivative of benzophenone, such as n-hexylbenzoic acid N,N-diethylaminohydroxybenzyl ester. UV-A and UV-B filters can of course also be used in combination. Other suitable UV filter materials are specified in the table below. No. substance CAS number (=acid) 1 4-aminophenyl phthalic acid 150-13-0 2 3-(4'-trimethylammonium)benzylidene decane-2-one sulfhydryl sulfate 52793-97- 2 3 salicylic acid 3,3,5-trimethylcyclohexyl ester (humulizate) 118-56-9 4 2-hydroxy-4-decyloxydibenzophenone (oxybenzone) 131-57 -7 5 2-Phenylbenzimidazole-5-sulfonic acid and its potassium, sodium and triethanolamine salts 27503-81-7 6 3,3(-(1,4-phenylene secondary methyl) bis( 7,7-Dimethyl-2-oxobicyclo[2.2.1]heptane-1-methanesulfonic acid) and its salt 90457-82-2 7 4-bis(polyethoxy)aminophenylhydrazine Acid polyethoxyethyl ester 113010-52-9 8 2-Dimethylaminobenzoic acid 2-ethylhexyl ester 21245-02-3 9 2-ethylhexyl salicylate 118-60-5 10 4 2-methoxyamyl cinnamate 2-isoamyl ester 71617-10-2 11 4-methoxyhexyl 2-ethylhexyl acrylate 5466-77-3 12 2-hydroxy-4·decyloxybenzophenone- 5-sulfonic acid (sulfonone) and sodium salt 4065-45-6 13 3-(4'-sulfonylbenzylidene)nonan-2-one and salt 58030-58-6 14 3-benzylidene Ketrendan-2-one 16087-24-8 15 1-(#-isopropylphenyl)-3-phenylpropane 4,3-dione 63260-25-9 16 Salicylic acid 4-isopropyl Benzyl ester 94134-93-7 17 3-mid 4-yl acrylic acid and its ethyl ester 104-98-3 18 2-cyano-3,3·diphenyl acrylate ethyl ester 5232-99-5 122883.doc -85 - 200816981 19 2-Chaotic-3, 3-monopropionate ethylhexanate Q7-10-4 20 o-Aminobenzoic acid Wei or: 5· Formate 134-09-8 21-Aminobenzoic acid glyceride or: 4-Amino-p-formic acid glycerol vinegar 136-44-7 22 2,2*-di-pyridyl-4-decyloxydibenzophenone (two by abundance 131-53-3 23 2 base-4-oxo Methyl 4-methyl benzoquinone (mexenone) 1641-17-4 24 triethanolamine salicylate 2174-16-5 25 dimethoxy phenyl glyoxylate or: 3 , 4-dimethoxyphenylethyl-aldehyde_acid sodium 4732-70-1 26 3-(4'-nonanoyl subunit) oxime-2-_ and its salt 56039-58-8 27 4 -T-butyl-4·-methoxydibenzylhydrazine methane 70356-09-1 28 2,2f,4,4'-tetrahydroxybenzophenone 131-55-5 29 2,2*- Methyl bis[6-(2H-benzotriazolyl) winter (^❿tetramethylbutyl) phenol] 103597-45-1 30 2,2Η1,4-phenylene)bis-1Η-benzimidazole -4,6-didecanoic acid, Na salt 180898-37-7 .31 2,4-bis-[4-(2-ethylhexyloxy)-2-hydroxy]phenyl-6-(4-A Oxyphenyl) (1,3,5)- Triazine 187393-00-6 32 3-(4-methylbenzylidene) camphor 36861-47-9 33 4-bis(polyethoxy)-p-aminobenzoic acid polyethoxyethyl ester 113010-52- 9 34 2,4-dihydroxybenzophenone 131-56-6 35 2,2'-di-diyl-4,4'-dimethoxybenzophenone _5,5'-disodium Acid ester 3121-60-6 36 benzoic acid, 2-[4-(diethylamino)-2-hydroxybenzyl hydrazide 1, hexyl ester 302776-68-7 37 2-(2H-benzotris- 2-yl)-4-mercapto-6-[2-methyl-3-[l,3,3,3-tetradecyl-1-[(trimethyldecyl)oxy]dioxane Propyl propyl 155633-54-8 38 monomethylpropoxy) benzyl]_4,4·diphenyl-i,3-butan 363602-15-7 Table 4 · Suitable photoprotective agent In addition to the first photoprotective substances of the above two groups, it is also possible to use a second photoprotective agent which interrupts the photochemical reaction chain which is triggered when UV radiation penetrates into the skin. Typical examples thereof are superoxide dismutase, catalase, tocopherol (vitamin E) and ascorbic acid (vitamin c). The other group is an anti-irritant which has an anti-inflammatory effect on skin damaged by UV light. Such materials are, for example, bisabolol, phytol and phytotriol. Antioxidants, mixtures, colorants, vesicles or carotenoid formulations according to the invention or antioxidants, mixtures, colorants prepared according to the method of the invention 122883.doc •86-200816981, likewise according to the invention The combination of microlipid or carotenoids with inorganic pigments that terminate uv rays is used in dermatological skin care. The latter is a metal oxide that is insoluble or slightly soluble in water. Pigments and/or other metal compounds mainly include zinc oxides (ΖηΟ), titanium oxides (Ti〇2), iron oxides (for example, 2〇3), and antimony oxides (Zr〇) 2) an oxide of cerium (Si〇2), an oxide of manganese (such as MnO), an oxide of aluminum (ΑΙΑ3), an oxide of cerium (such as Ce2〇3), a mixed oxide of a corresponding metal, and the like a mixture of oxides. • Inorganic pigments can be present here in coated form, ie surface treated. The surface treatment can be provided, for example, by providing a thin hydrophobic layer to the pigment by a method known per se as described in DE_A_33 14 742. Further, the above dermatological skin care product preferably contains a so-called peroxide decomposing agent which is a compound capable of decomposing a peroxide, particularly preferably a lipid peroxide. Salty, meaning organic matter, such as pyridine-2-thiol-3-carboxylic acid, 2-methoxypyrimidincarboxylic acid, 2-methoxy-picolinic acid, 2·dimethylamino (tetra)alcoholic acid, 2-Dimethylamino-formic acid. The amount of the dermatological skin care active ingredient (- or a plurality of compounds) in the preparation according to the invention is preferably from 1 to 3% by weight, particularly preferably from 0.05 to 20% by weight, based on the total weight of the preparation. 'especially 1 to 1% by weight.指定 The designations and other active ingredients used in the formulations according to the invention are set forth in DE 1〇3 18 526 Alt, pages 12 to 17, which is hereby incorporated by reference in its entirety. In a preferred embodiment of the present invention, the dermatological skin care product, preferably the skin treatment composition 122886.doc-87-200816981 f and the hair treatment composition comprises the total weight of the skin medical skin care product, Wang Hao. 001 to 1 weight %, preferably G.〇1 to G.9% by weight, particularly preferably 〇.01 to 〇: 8% by weight or 〇.01 to 〇.7% by weight, very particularly preferably (UH to 0.6% by weight or 〇 .01 to G.5% by weight, optimal G.G1 to G.4 by weight Mo.tn to 〇·3 by weight + concentration of the antioxidant according to the present invention, mixture _) 2),

Rd coloring J vesicles or carotenoid formulations or antioxidants, mixtures (M) or (eg) according to the method of the present invention, preparations, coloring tablets 1J, micro-salt or carotenoids Formulation. In another embodiment, the dermatological skin care product comprises U 10% by weight, preferably 2 to 8% by weight, 3 to 7% by weight, and 4 to 6% by weight, based on the total weight of the dermatological skin care product. Antioxidant, mixture ((4)) or (10)) according to the invention, formulation, colorant, vesicle or lysine formulation or antioxidant, mixture (M1) or (M2) prepared according to the process according to the invention , formulation, colorant, vesicles or carotenoid formulations. In an equally preferred embodiment, the dermatological skin care product comprises 20% by weight of the leg, preferably &lt; to 19% by weight, 12 to 18% by weight, 13 to 17 weight, based on the total weight of the dermatological skin care product. /. ’! Antioxidant, mixture (M1) or (M 2 ), formulation, colorant, vesicle or carotenoid according to the invention or an antioxidant prepared according to the process according to the invention at a concentration of from 4 to 16% by weight In a preferred embodiment, a mixture, a colorant, a vesicle or a carotenoid-like formulation, the dermatological skin care product comprises from 2 to 30 weight percent based on the total weight of the dermatological skin care product. /. , preferably 21 to 29% by weight, 22 to 28% by weight, to "weight 〇 / 〇, 24 to 26% by weight of the concentration of the antioxidant according to the date of the month, the mixture (M1) or (ritual), preparation , colorant, vesicle or carotenoid 122883.doc • 88- 200816981 Formulation or antioxidant, mixture (M1) or (M2), formulation, colorant, micro, prepared according to the method of the present invention a lipid or carotenoid formulation. In addition, the following applies to the dermatological skin care product according to the invention: The formulation base of the dermatological skin care product according to the invention preferably comprises a dermatological skin care or a pharmaceutically acceptable active ingredient or Auxiliaries. Pharmaceutically acceptable additives which are known to be suitable for use in the pharmaceutical, food technology and related fields, especially those listed in the relevant pharmacopoeia (such as dab ph. k BP NF). , and its nature does not exclude other auxiliaries for physiological applications. Suitable dermatological skin care or pharmaceutical auxiliaries may be: glidants, humectants, emulsifiers and suspending agents, preservatives, antioxidants, anti-irritants, Integrative agent, emulsion stability Agent, film former, gel forming agent, odor masking agent, resin, hydrocolloid, solvent, cosolvent, neutralizer, penetration enhancer, pigment, quaternary ammonium compound, fatliquor and fatliquor, ointment , cream or oil base, polyoxyl derivative, stabilizer, sterilizing agent, propellant, drying agent, sunscreen, thickener, wax, softener, white oil. The examples are based on Such as shown in, for example, Fiedler, Η·P· Lexikon der Hilfsstoffe ftir Pharmazie, Kosmetik and angrenzende Gebiete [Lexikon of auxiliaries for pharmacy, cosmetics and related fields], 4th edition, Aulendorf: ECV-Editio-Kantor_Verlag5 1 996 Expertise. For the preparation of a dermatological skin care product according to the invention, the active ingredient may be mixed with or diluted with suitable auxiliaries (excipients). The excipient may be a vehicle, carrier or active ingredient Solid, semi-solid or liquid material of the medium. 122883.doc -89 - 200816981 f, if necessary, mixing other auxiliaries in a manner known to those skilled in the art. In addition, polymers and dispersion The liquid is suitable as a auxiliaries in pharmacy, preferably as a coating composition or a binder for a solid pharmaceutical form or in a solid pharmaceutical form of a coating composition or a binder, which can also be used in a cream. As a tablet coating and a tablet adhesive. According to another preferred embodiment, the dermatological skin care product according to the present invention is a cosmetic composition for treating and protecting skin and hair, and a nail care combination for decorative cosmetics. Or preparation. φ a suitable dermatological skin care products are, for example, facial tonics, masks, deodorants and other cosmetic lotions. Composition packs for decorative cosmetics T (for example) concealer sticks, stage makeup, mascara and eye shadow, lipstick, eyeliner, eyeliner, blush, loose powder and eyebrow pencil. In addition, the 0/W dispersion can be used for nasal cleaning for pore cleansing, anti-acne composition, repellent, shaving composition, post-cosm and pre-treatment composition, after-sun care composition, depilatory composition, Hair dyes, personal hygiene group Φ compounds, foot care composition compositions and baby care. In addition to the above-mentioned compounds according to the invention and suitable carriers, the skin cosmetic preparations may also contain other active ingredients and auxiliaries which are conventionally used in the skin cosmetics as described above. These materials preferably include emulsifiers, preservatives, essential oils such as phytotriol, bisabolol, cosmetically active ingredients of ubiquinol, photoprotective 'bleaching' stains, colorants, tinctures, collagen , protein hydrolysates, stabilizers, pH adjusters, dyes, salts, thickeners, gelling agents 'consistency adjusters, polyoxyxides, humectants, fatliquors and/or other conventional additives. 122883.doc -90· 200816981 The preferred oils and fat components of dermatological skin care products are the above mineral oils and synthetic oils such as sarcophagus, pasta oil and aliphatic hydrocarbons having more than 8 carbon atoms, animal and vegetable oils, such as To 曰Caiyou, Ouzi oil, Avocado oil, E. sesame oil, lanolin, or wax, fatty acid, fatty acid ester, such as C6_c3 rouge - glycerin dimethoate, wax ester, such as jojoba oil, Fatty alcohol, petrolatum, hydrogenated lanolin and acetylated lanolin, and mixtures thereof. In order to produce a combination of properties such as improved (four) sensation, coatings, water resistance and/or active ingredients and auxiliaries such as pigments, dermatological skin care may additionally comprise a polyoxonium-based conditioning substance. . Suitable polyoxymethylene compounds are, for example, polyalkyl siloxanes, polyaryl oxy- oxy-combustions, polyaryl carbazates, polysphincters or polyoxin. Dermatological skin care products are prepared by conventional methods known to those skilled in the art. Fortunately, skin cosmetic skin care products exist in the form of emulsions, especially in the form of water-in-oil (W/0) or oil-in-water (〇/w) emulsions. • However, other types of formulations may also be chosen, such as gels, oils, oil gels, multiple emulsions such as in the form of W/0/W or 〇/w/〇 emulsions, water-relieving ointments or ointment bases, etc. . Emulsifier-free formulations, such as aqueous dispersions, hydrogels or piekering emulsi〇n, are also advantageous embodiments. The emulsion is prepared by a known method. The emulsion usually contains conventional ingredients such as fatty alcohols, fatty acid esters and especially fatty acid triglycerides, fatty acids =, flat hair fats and derivatives thereof, natural or synthetic oils or emulsifiers in the presence of soil and water. Selection of specific additives for emulsion type and preparation of suitable emulsions 122883.doc -91- 200816981 described in, for example, Schrader5 Grundlagen and Rezepturen der

Kosmetika [Fundamentals and formulations of cosmetics], Htithig Buch Verlag, Heidelberg, 2nd edition, 1989, Part 3, or Umbaeh, Kosmetik: Entwicklung, Herstellung and

Anwendung kosmetischer Mittel [Cosmetics: Development, production and use of cosmetic compositions], 2nd ed., 1995, Georg Thieme Verlag, ISBN 3 13 712602 9, page 12 2 and later, which is expressly incorporated herein by reference. Preferred fats and oils which may be present in the fatty phase of the emulsion are: hydrocarbon oils such as paraffinic oil, pserelin oil, perhydrosqualene and solutions of microcrystalline wax in such oils, animal or vegetable oils, such as Sweet almond oil, avocado oil, sea bream oil, lanolin and its derivatives, castor oil, sesame oil, olive oil, jojoba oil, quartz neon rock oil, Atlantic salmon oil, distillation under atmospheric pressure A mineral oil having a starting point of about 250 ° C and a distillation end point of 410 ° C, such as petroleum jelly, an ester of a saturated or unsaturated fatty acid, such as a decyl myristate such as isopropyl myristate, tetradecanoic acid Butyl ester or cetyl myristate, cetyl stearate, ethyl palmitate or isopropyl palmitate, caprylic or capric triglyceride and cetyl ricinoleate. The fatty phase may also contain an oxime oil which is soluble in other oils such as dimethyl polyoxime, nonylphenyl polyoxane, polyoxyethylene glycol copolymer, fatty acid and fatty alcohol. In addition to the above-mentioned compounds according to the present invention, dermatological skin care products may also contain waxes such as carnauba wax, canary wax, beeswax, microcrystalline wax, soil and Ca, Mg and A1 oleate, myristic acid. Salt, linoleic acid oleate and hard 122883.doc -92- 200816981 Fatty acid salt. According to another preferred luxury # , ^ ^ UK ^ 'The dermatological skin care product according to the present invention is a photoprotective composition, a shower gel, a shampoo formulation or a bath preparation, and the photoprotective preparation is especially Good. In addition to the antioxidants, mixtures (Ml) or (M2) according to the invention, formulations, colored backings or carotenoid formulations or antioxidants, mixtures, colorants, prepared according to the invention Outside of the vesicles or carotenoids, the formulations generally comprise φ anionic surfactant as a basic surfactant and amphoteric and/or nonionic twin interface/tongue as an auxiliary surfactant . Other suitable active ingredients and/or adjuvants are selected from the group consisting of lipids, essential oils, dyes, organic acids, preservatives and antioxidants, and thickeners/gel formers/skin conditioners and humectants. Preferably, the formulations comprise from 2 to 5 % by weight, preferably from 5 to 40% by weight, particularly preferably from 8 to 30% by weight, based on the total weight of the formulation. φ All anionic, neutral, amphoteric or cationic surfactants customary in body cleansing compositions can be used in laundry, shower and bath formulations. Suitable anionic surfactants are, for example, alkyl sulfates, alkyl-sulfates, alkyl sulfonates, alkyl aryl sulfonates, alkyl succinates, alkyl sulfosuccinates , N-alkyl decyl sarcosinate, decyl oxoate, decyl isothio sulphate, alkyl phosphate, alkyl ether phosphate, alkyl ether ferrite, α-dilute sulfonic acid Salts, especially metal salts and soil test metal salts, such as sodium salts, sulphate salts, magnesium salts, mom salts and money salts, and triethanolamine 122883.doc -93- 200816981 salts. The alkyl ether sulfate, alkyl ether phosphate and alkyl ether carboxylate may have between 1 and 10 ethylene oxide or propylene oxide units in the molecule, more preferably from 1 to 3 ethylene oxide units. Such materials include, for example, sodium lauryl sulfate, ammonium lauryl sulfate, sodium lauryl ether sulfate, ammonium lauryl ether sulfate, sodium lauryl sarcosinate, sodium oleyl succinate, sodium lauryl sulfonate. Ammonium, sodium dodecylbenzene sulfonate, tridecyl benzoic acid triethanolamine. Suitable amphoteric surfactants are, for example, alkyl betaines, alkyl decyl φ propyl betaine, alkyl sulfobetaines, alkyl glycinates, alkyl decyl glycinates, Alkyl amphoacetate or alkyl amphoteric propionate, alkyl amphoteric diacetate or alkyl amphoteric dipropionate. For example, cocodyl propyl propyl betaine, lauryl beet test, cocoamidopropyl betaine or sodium cocoamphopropionate can be used. Suitable nonionic surfactants are, for example, aliphatic alcohols or alkylphenols having from 6 to 20 carbon atoms in a linear or branched alkyl chain and oxyfluorene and/or propylene oxide. The reaction product. The amount of alkylene oxide is from about 6 to 60 moles per mole of alcohol. In addition, alkylamine oxides, monoalkylalkanolamines or dialkyl melamines, fatty acid esters of polyethylene glycol, ethylated fatty acid guanamines, alkyl polyglycosides or sorbitan ethers Esters are suitable. In addition, the wash, shower and bath formulations may contain customary cationic surfactants such as quaternary ammonium compounds such as cetyltrimethylammonium chloride. In addition, the shower gel/shampoo formulation may contain such as sodium chloride, 卩£. -: 55, propylene glycol oleate, 00_12 〇 methyl gluten dioleate and other substances thickeners and preservatives, other active ingredients and auxiliaries and 122883.doc -94- 200816981 water 0 In addition, The antioxidant, mixture (Ml) or (M2), formulation, colorant, vesicle or carotenoid formulation according to the invention in a hair cosmetic preparation provides protection against premature aging of human hair, and Thus, for example, it is used as an active ingredient for cosmetic treatment of fragile, matt and inelastic hair. A dermatological skin care product for protecting hair according to the present invention is, for example, a shampoo composition, applied before or after rinsing the hair, before or after shampooing, before or after constant wave treatment, before or after coloring or decolorizing the hair. A dermatological skin care product, a dermatological skin care product for drying or finishing hair, a dermatological skin care product for coloring or discoloration, a styling and therapeutic lotion, a hair spray or a constant wave composition. Suitable auxiliaries and additives for the preparation of dermatological skin care products for the protection of hair are known to those skilled in the art and can be found in cosmetic handbooks, for example in Schrader, Grundlagen and Rezepturen der Kosmetika • [Fundamentals and formulations of cosmetics ], Huthig Verlag, Heidelberg, 1989, ISBN 3-7785-1491-1, or Umbach, Kosmetik: Entwicklung, Herstellung and Anwendung kosmetischer Mittel [Cosmetics: Development, production and use of cosmetic compositions], 2nd edition, 1995 , Georg Thieme Verlag, ISBN 3 13 712602 9 in. A dermatological skin care product for protecting hair comprises an active ingredient and an auxiliary agent in the type of dermatological skin care product which is conventionally used for the protection of hair and hair treatment. Used as active ingredients and auxiliaries, for example, preservatives, surfactants 122883.doc -95- 200816981, foam-preventing substances, thickeners, emulsifiers, fats, oils, organic solvents, fungicides An essential oil, a cosmetic preparation and a dermatological preparation, an electrolyte or a substance for preventing hair greasy, which is intended to be used for the hair, or the tea or the pigment or the hair. For the purposes of the present invention, it is understood that electrolytes mean water-soluble alkali metal salts, ammonium salts, alkaline earth metal (including magnesium) salts and zinc salts of inorganic anions and any mixtures of such salts, and it is necessary to ensure that the characteristics of the salts are Medical acceptability or cosmetic acceptability. The anion according to the present invention is preferably selected from the group consisting of chloride:, sulfate and hydrogen sulfate, Weigen, (tetra)hydrogen and linear and cyclic oligomeric discs, and carbonate and bicarbonate. . If the dermatological skin care product for protecting hair is in the form of a lotion, the bean system (for example) is rinsed before or after decolorization, before or after shampooing, between 2 shampooing steps, before or after constant wave treatment. And application, which is, for example, an aqueous solution or a water-alcohol solution containing, where appropriate, a concentration of from 1 to 10% by weight, preferably from 0.2 to 5 weight percent, based on the total weight of the formulation. 〕 The surface active substance in the dry area of Xiali/〇 is used to protect the hair in the form of a lotion. The skin medical skin care that is not washed out is especially used for finishing the hair and hair of the hair. The backing or styling and therapeutic lotion used in drying the hair, the $ ^ ^ κ passband is a water solution, an alcohol solution or a water-alcohol/liquid mixture and contains at least one sod, anionic, non- An ionic or a two-spotted complex, or a mixture thereof, a lignan, a saponin, an enteric sinusoid, an enteric 1 ~ Luo Luoji, Luo Yi alcohol, rosin phenol, lilac resin 122883.doc -96- 200816981 Hope, isoflavone Larch resin and furfuryl alcohol glycosides. The lanthanide of the polymer used is, for example, in the range of from 1 to 10% by weight, preferably from 1 to 3% by weight, based on the total weight of the formulation. The skin-care product comprising the antioxidant according to the present invention for protecting hair may be in the form of a nonionic or anionic type of emulsion. In addition to water, the nonionic, topical emulsions may also comprise, for example, a polyethoxylated or polypropoxylated oil or fatty alcohol, or a mixture of two organic components. If appropriate, the emulsions comprise a cationic surface active. / According to the invention, the dermatological skin care product for protecting hair may be in the form of a gel, in addition to an effective amount of at least one compound (7) or an effective amount of an antioxidant, a mixture (Μ1) or (Μ2), a formulation, a coloring agent, a micro In addition to the lipid granule or the carotenoid formulation, it preferably further comprises water, an organic bulking agent such as acacia, sinensis, sodium alginate, a cellulose derivative, preferably methylcellulose, μ. Methylcellulose, by B (IV) "for A ~ ? &amp; base cellulose, hydroxypropyl fiber ', hydroxypropyl methyl cellulose, or such as citric acid such as bentonite, or polyethylene glycol and poly... t..., the machine is slightly mixed with a 'example. The addition agent is exemplified by (for example - phthalate or distearate tongue (for example) 0.1 to 30% by weight. /, preferably 0 5 to i 5 The amount within the range of ϊ/ϊ is present in the gel. · In addition to the effective amount of the antioxidant according to the present invention, the skin composition of the shampoo composition is used to modulate anionic, non-ionic: "It is preferred to include at least one of the four amphoteric surfactants (when appropriate) according to the invention. Disintegration and as the usual use, the surface active substance can be! Weight% to 94%, the auxiliary agent in the table. The concentration in the hair essence is present in the wash 122883.doc -97- 200816981 according to the present invention The dermatological skin care product may also be an aqueous dermatitis constituting a cleansing composition or a low water or anhydrous cleansing composition concentrate intended for aqueous cleaning, which may comprise anionic, nonionic and/or amphoteric surfactants. For example, conventional soaps, such as sodium fatty acid salts, alkyl sulfates, sulphur-based sulphates, sulphuric acid sulphates, succinic acid salts, tartaric acid acetates, base-based sweets , sarcosinate, guanamine-based acid beet test, lysyl succinate (tetra) salt, ketone _ acid half §, ketone group acid, protein _ fatty acid condensate, burnt beet test and guanamine Betaine, fatty acid alkanolamine, polyglycol ether derivative. The skin care product according to the present invention for protecting hair is preferably in the form: styling foam, hair mousse, hair gel, Shampoo, hair spray, hair foam beads, final fluid, use Constant wave neutralizer, half hair agent and bleach or hot oil treatment agent. Depending on the application field, hair cosmetic agents can be (aerosol) spray, (aerosol) beads, gel, gel spray; Application in the form of a cream, lotion or wax. The hair spray here contains an aerosol spray without a propellant gas and (iv) a mist. The hair material contains an aerosol bubble with no propellant gas and a pumping material. Hair spray and wool foam beads Preferably, the water-soluble or water-dispersible component is mainly or exclusively included. If the compound used in the hair spray and hair powder according to the present invention is water-dispersible, it may have a particle size of usually 1 350 nm, preferably β25. The aqueous microdispersion of hydrazine (10) is used in the form of a solid content of such preparations, usually in the range of from about Μ to about 重量%. The microdispersions generally do not require an emulsifier or surfactant for their stabilization. . ^ 'Shrimp understanding' other ingredients means additives commonly used in cosmetics, such as 122883.doc •98· 200816981 Ingredients, antifoaming agents, interfacial active compounds', ie surfactants, emulsifiers, foaming beads And solubilizer. Interfacially active compounds used: ionic, cationic, amphoteric or neutral. Other conventional ingredients are also; for example, antiseptic essential oil, sunscreen, active ingredient, uv filter, care substance such as ubiquinol, collagen, vitamins, protein = hydrolysate, α• warp-based acid and β. warp acid, stable (four), pH adjustment agent, dye, viscosity modifier, gelling agent, salt, moisturizer, fatliquor, compounding agent and other conventional additives.曰

These materials further include all of the styling and conditioning polymers known in cosmetics. If desired to set very specific properties, they can be combined with the microcapsules according to the invention or the clear dispersions prepared according to the process of the invention. Use 0 ★ Suitable conventional hair cosmetic polymers are, for example, the above-mentioned cationic, anionic, non-ionic, nonionic and amphoteric polymers, which are used herein to set certain properties, and the sword can be p The M a person table W may additionally contain a sputum substance mainly composed of a polyoxyl compound. Suitable flat sputum gas... The scorpion compound is, for example, polyalkyl oxime, polyaryl oxyhydrogen, sulfonium fluoroalkyl alkane, polyether siloxane, polyoxyl Resin or dimethylpoly(M)' alkane copolyol (CTFA) and an amine functional polyoxyl compound such as an amine hydrazine oil (€: butyl octa). Propellants are propellants commonly used for hair sprays of propane/butane mixtures, (HFC-152 a), carbon dioxide, mist or aerosol foams. Pentane, dimethyl ether, l,l-difluoroethane nitrogen or compressed air is preferred. Emulsifiers which can be used are all emulsifiers customary in hair foams. Suitable emulsifiers can be nonionic, cationic or anionic or amphoteric. An example of a nonionic emulsifier 〇NCI nomenclature) is lauryl ether, such as lauryl ether _4; cetyl ether, such as cetyl ether-1, polyethylene glycol cetyl ether, cetyl stearin Alcohol ethers, such as cetearyl ether _25, polyethylene glycol fatty acid glycerides, hydroxylated lecithin, fatty acid decyl esters, alkyl 'polysaccharides. Examples of cationic emulsifiers are cetyl dimethyl _ 2 hydroxyethyl phosphonium sulfonate, chlorinated soil, triammonium, chlorinated triammonium, cocoa trimethyl 0 methyl sulfate , four grade ammonium. The anionic emulsifier may be selected, for example, from the group of the following: alkyl sulfate, alkyl ether sulfate, alkyl sulfonate, alkyl aryl sulfonate, alkyl succinate, alkyl Sulfosuccinate, mentholyl sarcosinate, decyl taurate, decyl isothiosulfate, alkyl phosphate, alkyl ether phosphate, alkyl ether carboxylate, alpha An olefin sulfonate, especially an alkali metal salt and an alkaline earth metal salt, such as a sodium salt, a potassium salt, a magnesium salt, a calcium salt and an ammonium salt, and a triethanol φ amine salt. The alkyl ether sulfate, alkyl ether phosphate and alkyl ether carboxylate may have from 1 to 10 ethylene oxide or propylene oxide units in the knives, preferably from i to 3 ethylene oxide units. Gelling agents which can be used are all gelling agents customarily used in cosmetics. Such materials include, for example, Carbomer (INCI) lightly crosslinked polyacrylic acid, such as propyl cellulose, hydroxyethyl cellulose, cellulose derivatives of cationically modified cellulose, such as Sanxian gum Polysaccharide, caprylic acid/capric acid triglyceride, sodium acrylate copolymer, polytetraammonium _32 (and) stone% oil (INCI) 'sodium acrylate copolymer (and) sarcophagus oil (and) ppG- ;l 122883.doc •100· 200816981 Triterpene polyether-6, propylene chloride guanidinopropyl triammonium hydride/propylene amide copolymer, stearyl polyoxyethylene ether-1 〇 allyl ether , acrylate copolymer, polytetra-ammonium-37 (and) paraffin oil (and) ρροη triterpene polyether-6, polytetraammonium 37 (and) propylene di-dithioate dicaprylate (and Wpgj triterpene polyether-6, polytetraamethylene-7, polytetraammonium 44. In shampoo formulations, all anionic, neutral, amphoteric or cationic used in shampoos can be used. Sexual surfactants. Suitable anionic surfactants are, for example, alkyl sulfates, alkyl ether sulfates, alkyl sulfonates, alkanes. Aryl sulfonate, alkyl succinate, alkyl sulfosuccinate, decyl decyl sarcosinate, decyl taurate, decyl isothio sulfate, alkyl phosphate, Alkyl ether phosphates, alkylates, olefin sulfonates, especially alkali metal and alkaline earth metal salts such as sodium, potassium, magnesium, calcium and ammonium salts and triethanolamine salts. The alkyl ether phosphate and the alkyl ether carboxylate may have between 1 and 10 ethylene oxide or propylene oxide units in the molecule, preferably from ! to 3 ethylene oxide units. Suitable for (for example) Sodium lauryl sulfate, ammonium lauryl sulfate, sodium lauryl ether sulfate, ammonium lauryl ether sulfate, sodium lauryl sarcosinate, sodium oleate, ammonium lauryl sulfosuccinate, dodecane Sodium benzene sulfonate, dodecyl benzene citrate triethanolamine. Suitable amphoteric surfactants are, for example, benzalkonine, decyl propyl propyl betaine, alkyl sulfobetaine, alkane Glycosylamine, alkylcarboxyglycinate, alkyl amphoacetate or alkyl amphopropionate, alkane Amphoteric diacetate or alkyl amphetyl dipropionate. 122883.doc -101 - 200816981 For example, cocodyl propyl sulfobetaine, lauryl betaine, cocoapropyl propyl beet can be used. a base or a cocoa amphoteric acid propionate. Suitable nonionic surfactants are, for example, aliphatic alcohols or alkylphenols having 6 to 20 carbon atoms in an alkyl chain which may be linear or branched. a reaction product of ethylene and/or propylene oxide. The amount of oxidizing is about 6 to 60 moles per mole of alcohol. Further, 'alkyl amine oxide, monoalkyl alkanoate or dialkyl alkanolamine, Fatty acid esters of polyethylene glycol, alkyl polyglycosides or sorbitan ether esters are suitable.

Additionally, the shampoo formulations can comprise conventional cationic surfactants, such as a fourth ammonium compound, such as cetyltrimethylammonium chloride. The # substance includes, for example, the above-described cationic polymer having the INCI name polytetra-ammonium, especially a copolymer of vinylpyrrolidone/N-vinylimidazolium salt (Luviquat FC, Luviquat &amp;commat, HM,

Luviquat MS, LuViquat Care), copolymer of N-vinylpyrrolidone/dimethylaminoethyl methacrylate quaternized with bismuth sulphate (Luviquat D PQ U), N_vinylene The copolymer of decylamine with vinylpyrrolidone/N-vinylimidazolium salt (Luviquat DH〇id), cationic cellulose ho (organic tetra-ammonium.4 and polytetra-ammonium-1G), propylene roast Amine amine copolymer (poly quaternary record _7). In addition, (4) protein f hydrolysate and polyoxonium-based regulators, such as polyalkyl siloxane, polyaryl siloxane, polyaryl alkyl siloxane, polyether siloxane or Polyoxygenated resin. Other suitable polyoxo compounds are dimethicone (CTFA) and amine functional polyoxygen compounds, such as the amine backbone (CTFA). Further, a cationic guar derivative such as guar chloride propyl propyl methacrylate 122883.doc 200816981 (INCI) can be used. According to another embodiment, the hair cosmetic preparation or the skin cosmetic preparation is used for the care or protection of the skin or hair and is in the form of an emulsion, a dispersion, a suspension, an aqueous surfactant preparation, a milk, a lotion, a cream, Balsam, ?, gel, granules, powder, stick preparation such as lipstick, bubble bed, air-cooled glue or spray. These formulations are highly suitable for topical formulations. Suitable emulsions are oil-in-water emulsions and water-in-oil emulsions or microemulsions. Often the dermatological skin care products used to protect hair are used for application to the skin # (局°) or hair. It is understood that topical dermatological skin care products are suitable for applying the active ingredients to the skin in such a manner as to be finely distributed and preferably absorbed by the skin. The hydrazine for this purpose is, for example, an aqueous solution and a water-alcohol solution, a spray, a foam, a foamed aerosol, an ointment, an aqueous gel, a 〇/W4W/0 type emulsion, a microemulsion or a cosmetic stick preparation. According to the dermatological skin care product according to the present invention for protecting hair, the dermatological skin care product comprises a carrier. Preferred carriers are water, gases, water-based liquids, oils, gels, emulsions or microemulsions, dispersions or mixtures thereof. The specified carrier exhibits good skin compatibility. Topical formulations with particular advantages are aqueous gels, emulsions or microemulsions. Emulsifiers which can be used are nonionic ionic surfactants, zwitterionic surfactants, amphoteric surfactants or anionic emulsifiers. The emulsifier may be present in the composition according to the present invention in an amount of from 0.1 to 10% by weight, preferably from 1 to 5% by weight. The non-generated ionic surfactant used may be, for example, a surfactant from at least one of the following group 122883.doc-103.200816981: 2 to 30 m〇i of ethylene oxide and/or to 5 mol. The addition of propylene oxide to a linear fatty alcohol having C 22 carbon atoms on a fatty acid having c12-C22 carbon atoms and an alkylphenol having 〇8-015 carbon atoms in the alkyl group a product of 1 to 30 mol of ethylene oxide added to glycerol, 12-(18 fatty acid monoesters and diesters; saturated and unsaturated fatty acids having C6_C22 carbon atoms and ethylene oxide addition products thereof Monoglycerides and diesters and sorbitan Φ sugar monoesters and diesters; alkyl monosaccharide and oligoglycosides having C8_C22 carbon atoms in the alkyl group and ethoxylated analogs thereof; 15 to 60 Addition products of mol of ethylene oxide on castor oil and/or hydrogenated castor oil; polyols and especially polyglycerides such as polyglycerol polyricinoleate, polyglycerol poly 12-hydroxystearate or polyglycerol Dimer. Also suitable for two or more of these substance classes a mixture of 2 to 15 mol of ethylene oxide on castor oil and/or hydrogenated castor oil; a partial ester based on the following: linear, branched, unsaturated or saturated ^22-Fatty acids, ricinoleic acid and 12-hydroxystearic acid and glycerol, polyglycerol, isovaerythritol, diisoamyltetraol, sugar alcohols (such as sorbitol alkyl sugar (such as methyl sugar bitter , butyl saccharides, lauryl saccharides and polysaccharides (such as cellulose); monoalkyl phosphates, dialkyl phosphates and trialkyl phosphates, and hepta-mono-PEG-burning, acid-breaking two pEG Burning vinegar and, or filling acid, three vinegar and its salt. In addition, the zwitterionic boundary, the alpaca interface / tongue agent can be used as an emulsifier. Zwitterionic 122883, doc 200816981 Sexual surfactant is used to refer to a term having at least one quaternary ammonium group and at least one citrate group or a sulfonate group in the molecule which is surface-activated. Particularly suitable zwitterionic surfactants are so-called sweet two tests. , such as N-N'N-A having 8 to _ carbon atoms in a burnt or acid group under each condition Ammonium glucosamine, such as ammonium cocoalkyl dimethylglycolate 'N-decylaminopropyl hydrazine, hydrazine dimethyl dimethylamine (10), exemplified by dicocoyl propyl dimethyl dimethyl Ammonium glycinate and 2-alkyl-based _3_m f-based _3_ thio-ethyl imiline (tetra)' and silk methylglycolic acid cocoa decylaminoethyl:

Base ethyl ester. Particularly preferred are fatty acid guanamine derivatives which are known by the CTFA name cocoa propyl propyl beet. Equally suitable emulsifiers are amphoteric surfactants. It is understood that the amphoteric surfactant means a surface active compound which contains at least one free amine group and at least one -C00H or -S03H group and is capable of forming an internal salt, in addition to a C8_C-8 alkyl group or a fluorenyl group in the molecule. . Examples of suitable amphoteric surfactants are N-alkylglycines, N-alkyl propionic acids, N-alkylaminobutyric acids having from about 8 to 18 carbon atoms in the alkyl group under each condition, N-alkyliminodipropionic acid, N-hydroxyethyl-N-alkylnonylpropylglycine, N-alkyl tartaric acid, N-alkyl creatinine, 2-alkane Aminopropionic acid and alkylamino acetic acid. Particularly preferred amphoteric surfactants are N-cocoalkylaminopropionate, cocoylaminoethylaminopropionate and c12_c18 mercaptocreatine. In addition to amphoteric emulsifiers, fourth-grade emulsifiers are also suitable, with those having the ester quaternary type 'preferred thiol-quaternary di-fatty acid triethanolamine ester salt being especially preferred. Further, the anionic emulsifier which can be used is an alkyl ether sulfate, a monoglyceride sulfate, a fatty acid sulfate, a sulfonic acid porphyrin 122883.doc-105-200816981 and/or a _acid. Suitable oil bodies are gebbitt alcohols mainly composed of 6 to 18, preferably 8 to 1 carbon atoms, linear CpC22 fatty acids and linear CM fatty alcohols, and branched chains C6_Cn carboxylic acid and linear fatty alcohol i _ 'straight chain C6-C22 fatty acid and branched chain alcohol, especially 2 · ethylhexanol ester, linear and / or branched chain fatty acid and polyol (such as propylene glycol, a poly a diol or a triglyceride) and/or a gypsum alcohol, a triglyceride mainly composed of c6_c fatty acid, a liquid monoglyceride/diglyceride mainly composed of a CrC!8 fatty acid, a mixture of triglycerides, c^C22 fatty alcohols and/or gibbutols with aromatic carboxylic acids, especially esters of benzoic acid, C2_Cu dicarboxylic acids and linear or branched alcohols having up to 22 carbon atoms or Polyol having 2 to 1 carbon atoms and 2 to 6 hydroxyl groups, vegetable oil, branched chain primary alcohol, substituted cyclohexane, linear G-C22 fatty alcohol carbonate, diabet carbonate, benzene a methyl ester and a linear and/or branched C6_C22 alcohol ester (eg FinsMv® TN), a dialkyl ether, an epoxidized fatty acid ester and a ring opening product of a polyol, One oil and / or aliphatic or cyclic hydrocarbons. The oil body that can be used is also a polyoxyxide compound, such as dimethyl polyoxan, methyl phenyl polyglycol, cyclic polyoxo and amine, fatty acid, alcohol, poly bond, epoxy A fluorine, a topographical and/or a sugar modified polyoxo compound which may be in liquid form or in resin form at room temperature. The oil body content of the composition according to the invention may range from 丨 to 90% by weight of the composition, preferably from 5 to 80% by weight and especially from 1 to 5% by weight. Another embodiment of a perfume dermatological skin care product is a perfume comprising at least one compound (V), a mixture (M1) or (M2), a formulation, a colorant, a vesicle 122883.doc-106-200816981 or a carotenoid The formulation has either been prepared using it. The hydrophobic agent is an alcohol solution of a suitable odorant or aroma, and the odorant or the aroma is mainly composed of essential oils of plant origin or synthetic origin, but may also be obtained by each animal and is, for example, an animal gland. Substance secretion. The fragrance system is used on the outside for human body and is often used to make a lot of solids and liquids scent. Perfume can be classified by the amount of essential oil in (especially) pure ethanol, which can be diluted with water (as appropriate) to 7% by weight. It is generally divided into a perfume having an essential oil of 10 to 25% by weight; an eau de parfum having an essential oil of 8 to 1% by weight; an eau de toilette having an essential oil of 5 to 8% by weight (eau de T〇ilette); eau de Cologne with 2 to 5% by weight of essential oils. The weight percentage is based on the total weight of the perfume. The odour effect of perfume usually consists of three elements; the top note, which contains a volatile odorant or essential oil with the main fresh characteristics; the middle tone, which contains a moderately volatile odorant or essential oil often having floral characteristics; It has a less volatile odorant or essential oil and determines the basic characteristics of the perfume (dominant odor). Perfume can be sub-divided according to the fragrance or the fragrance or tone: the aldehyde fragrance contains a fresh and fruity scent to the heart 2 aldehyde. The Green note is mainly composed of herbal _ fresh synthetic aldehydes, alcohols and esters. The floral notes are, for example, jasmine essential oils, rose oils, complex mixtures of synthetic aromatics such as acetate phenol and phenylethanol. Herbal spicy notes include, for example, lavender, A. sinensis extract and Example 2 cinnamon spice' and are commonly used in men's fragrances. The oriental notes are heavy and sweet and the animal notes are enhanced. 122883.doc 107 - 200816981

The perfume is usually dispensed to the tail.&apos; These perfumes increase the combination and strength of the volatile odorant and stabilize the perfume composition. With adjuvants, it is possible to connect the first, middle and tail notes more closely and to make the fragrance smoother. The preservative can be, for example, distinguished as an intrinsic perfume, a pseudo-scent, a true fragrance or a stimulant and consists of a natural substance, a synthetic analog or a synthetic substance. It exists in liquid form or in a viscous to crystalline form. Examples of substances or extracts that can act as a scenting agent are: coumarin, diethylene glycol methyl ether, amber, beaver, musk, civet, musk ketone, some macrocyclic _, scenting agent 404 or Extracts of rock rose, Su Hexiang, Tulu gums (t〇lubaisam), benzoin γ iris, oak moss, and eucalyptus. In perfumes, there are other substances such as emulsifiers or stabilizers, antioxidants or preservatives in addition to essential oils or odorants or aromas. The perfume according to the invention generally comprises, based on the total weight of the perfume, 〇3〇% by weight, preferably 0.01% to 15% by weight, particularly preferably 〇〇5 to 5 dandan, preferably from 01 to 2% by weight. The antioxidant of the present invention, -Ml) or (M2), a formulation, a colorant, a liposome formulation. 1 匐 匐 善 is applied to human skin, but it can also be used, for example, in modified or soft dermatological skin care products, for example, in soap-based medical skin care products = or mixtures thereof, or with such skin parts , dental and denture care according to the present invention &gt; ^ toner, micro-coupling, _, system, other intended use of the moon radix I) formulation; 122883.doc 200816981 mouth, dentistry and dentures The composition of the care comprising or having been prepared using the same. For the purposes of the present invention, compositions for oral, dental and denture care are meant, for example, in textbooks such as Umbach: Kosmetik: Entwicklung, Herstellung and Anwendimg kosmetischer Mitt el [Cosmetics: Development, production and use of cosmetic compositions , Chapter 7, pages 187-219, 2nd Extended Edition, 1995, Georg Thieme Verlag, ISBN 3 13 712602 9, (hereby explicitly referenced therein), suitable for oral, dental and dentures All compositions and forms of supply for hygiene. Such compositions and forms of supply are known to those skilled in the art and include, for example, dentifrice, dental creams, toothpastes, children's dental creams, dental gels, liquid dental creams, mouthwashes. Oral rinse, although this list should not be considered an exhaustive list. The preparation of such compositions is known to those skilled in the art and can be found in general textbooks (e.g., Umbach: Kosmetik: Entwicklung, Herstellung and Anwendimg kosmetischer Mittel [Cosmetics:

Development, production and use of cosmetic compositions], 2nd ed., 1995, Georg Thieme Verlag, ISBN 3 13 7126029). Thus, in addition to the antioxidant, mixture (Ml) or (M2), formulation, colorant, vesicle or carotenoid formulation according to the present invention, such compositions may also be included by those skilled in the art. Know the other ingredients. Such materials may be, for example, surfactants, cleansers, binders, humectants, consistency regulators, preservatives, dyes, perfumes, and sweeteners, although the list is not considered 122883.doc -109. 200816981 An exhaustive list. The active ingredients and auxiliaries specified may be active ingredients and auxiliaries for preventing dental caries and gingival inflammation. In this connection, fluoride is especially mentioned. In addition, the active ingredients and adjuvants can, for example, be effective against plaque and tartar formation, promote remineralization, reduce sensitivity to sensitive necks, or protect gums. Described here in the textbook Umbach: Kosmetik: Entwicklung, Herstellung^ Anwendung kosmetischer Mittel [Cosmetics: Development, production and use of cosmetic C〇mP〇sitions], 2nd edition, 1995, Ge〇rg %, ISBN 3 13 712602 9 Examples of the preparations on pages 205 to 207 are referenced. 0 Very invented,,, one, 丨8q sigh, work-group, first encounter $ contains a combination for ankle, dental and denture care 0.01 to 3 重量% by weight, preferably 0.01% by weight to 15% by weight, particularly preferably (10) to 5% by weight, very particularly preferably 01 to 2% by weight of the oxidizing agent according to the present invention, Mixture_ or (10)), formulation, colorant, micro-grain or carotenoid-like formulation. The use of compositions for oral, dental and denture care is generally known to those skilled in the art and to the users of such compositions. The composition is based on Shanghai:! Entrance! Or, for example, in a suitable container, the compositions are contacted with the target or used for care (e.g., dentures) and depending on the particular group;: are removed again after a certain contact time. For the use of compositions for oral, dental and denture care, today, t aids. ° w Other medical products such as toothbrushes 122883.doc -110- 200816981 The present invention further provides an anti- or (M2), formulation, coloring agent, micro-M, compound _ 筚 筚 筚 根据 心Or a carotenoid formulation in the preparation of (Ml) or _, preparation, coloring 1 differentiation, mixture tablets J i attacking the sun granules or carotenoids g may be due to its antioxidant protection (four) for coloration, m formulation used as Active ingredient. Antioxidant protection as an auxiliary or eight "...", for example, a pharmaceutically active finished product = other pharmaceutical ingredients that are formulated without additives, and which make the medicine for the preparation of a pharmaceutical product or in a pharmaceutical product, The chemically-formed form 'is particularly preferably in pure form and very particularly preferably in crystalline or micronized form or in the form of agglomerates, or in the form of a mixture of such substances. 0 Pharmaceuticals comprising at least one pharmaceutically effective concentration A pharmaceutically active ingredient and all compositions for preventing or treating a disease in a human or an animal. The composition may be, for example, in the form of an aerosol, a drop, an ointment, a gel, a lozenge, a dragee or a suppository, or It is present in other adjuncts, for example in a plaster. Furthermore, the antioxidant according to the invention can be used as an active knife in pharmaceuticals, especially in physiological processes or pathological processes which are affected by oxidation. Examples of such processes are macular degeneration, inflammation, cardiovascular disease, arteriosclerosis, stroke, heart attack, Alzheimer's and other neurodegenerative effects. The compound (v) or the antioxidant according to the invention can be used in a medicament similar to the carotenoid ether analogues of US 2005/0065096 A1. It also gives possible applications 122883.doc -111 - 200816981 Examples of the field, the application form which can be advantageously used or the protecting group which is easily cleaved 0 The compound (V) is preferably present in the form of a physiologically compatible form and/or in a form which is readily soluble in an aqueous medium. In the case of a physiologically compatible salt form and/or derivatized by a readily cleavable protecting group, the pharmaceutical product according to the invention generally comprises from 0.01 to 30% by weight, based on the total weight of the pharmaceutical product, preferably 〇抗1 to 15% by weight, particularly preferably 〇〇5 to 5% by weight, very particularly preferably n2% by weight of the antioxidant according to the invention

Know the oral substance (called (M2), preparation, s coloring agent, vesicle or carotenoid formulation. The use of the corresponding commercial drug is, for example, the type and concentration of the active ingredient present in the pharmaceutical product. And physiological availability constraints. In addition, it depends on the type of treatment and/or the type of disease to be treated prophylactically. The application form, the application site, and the concentration of the active ingredient are all familiar to those skilled in the art. Food and animal feeds, which comprise at least one chemical mixture (Ml) or (M2), a formulation, or have been used in accordance with the invention to further provide a food or animal feed (V) or an antioxidant according to the invention Preparation of a preparation, a coloring agent, a vesicle or a genus. The field compound (V) is preferably enriched, particularly preferably crystalline or microscopic, especially preferably in pure form and in the middle. The form is used for the understanding of food and animal feed, and the food means all substances and substances suitable for human consumption. The products are related to products such as baked products, dairy products, Animals such as meat and sausage Source products, vegetables and fruit products, desserts and sweets, snacks such as potato chips or salt and pepper, and chewing gum, jelly products or beverages such as soft drinks or alcoholic beverages. These foods can be supplied for consumption, such as acid condensation, Sausage or beverage, as a crude product for processing in a restaurant or home, as a finished product, such as a cold-rolled dish or instant soup, or as a mixture for further processing, such as a baking mixture for home use or bakery or (for example) as egg yolk powder. In addition, the term includes foods that have a special effect on the body. Examples thereof are health foods, functional foods, isotonic beverages, and food supplements in the form of juices, lozenges, and hair. a foaming agent, a dragee, a gel, a gel, a gelatin capsule such as a hard gelatin capsule or a soft gelatin capsule, a powder or dispersion, a suspension or a solid. The excluded food is a compound comprising a naturally occurring organism. A food product of (Ia) or a compound (π) or a mixture thereof, which may be erythematous cheese, egg, poultry or poultry skin. For the purposes of the present invention, foods are also used for prophylactic or therapeutic use. It is understood that preventive use of food means that certain health promoting ingredients or harmful ingredients that are rich in so-called health foods have been Foods removed or reduced therefrom. For the purposes of the present invention, it is understood that therapeutic foods are intended to reduce body weight and are also used, for example, in popular and competitive sports, especially in bodybuilding. Constructing a muscle food. Here, the use of the antioxidant according to the invention or a preparation comprising the same according to the invention in a therapeutic food is explicitly included. Furthermore, the 'therapeutic composition can improve the lean body mass of humans. Yi Shi 122883.doc -113- 200816981 In the examples, it is understood that therapeutic compositions mean compositions for the prevention and for the therapeutic treatment of nutritionally related, hereditary or obesity caused by metabolic disorders. In the therapeutic treatment of obesity, the formulations of the present invention may be formulated and usually formulated in a manner known to those skilled in the art, and may be used in the preparation of pharmaceutical dosage forms using conventional techniques. Such techniques are described, for example, in &apos;Remington&apos;s Pharmaceutical Science Handbook, Mack Publishing Co., New York, USA, 17th Edition 1985. The formula or food additive may be in the form of, for example, a liquid φ body or solid in the form of a powder, a premix, a lozenge, a capsule, a dragee, an aerosol, a solution, a dispersion or a suspension. It relates to animal feed for animal fattening, for standard feed or for promoting health or appearance, for example for coloring feathers. The animal feed to be excluded is an animal feed comprising the naturally occurring compound (Ia) or (ΪΙ) or a mixture thereof. Animal feeds comprising naturally occurring organisms that produce at least one of compounds (la) or (II) are also excluded. • For the purposes of the present invention, it is understood that an animal organism means an organism designated as an animal kingdom (animal) in a classification. Here, vertebrates (vertebrate doors) for terrestrial vertebrates (four-legged animals) and fish (fish) are preferred. Particularly preferred are avian (birds) and mammalian (mammal). However, invertebrates, especially Crustacea, such as shrimp and crab, or echinoderms, such as seaweed (Holothuroidea), are not excluded. Very particularly preferred are the following: true pigs (Suidae), cattle (B〇vlnae), horses (Marco, pheasant and related animals) (雉科122883.doc -114- 200816981 (Phasianidae)), ducks, geese and swans (Anatidae), parrots (PSittacif〇rmes), cockroaches (Fringillidae), squid (Fringillidae) Cyprinidae)) and the carp family (Salm〇nidae). Among the subjects, the best are so-called livestock and beneficial animals. For the purposes of the present invention, it is understood that livestock means not living freely. Animals that are familiar with humans and are mainly fed by humans at home. Particularly preferred livestock are Felis silvestds forma catus and dogs (lupus familiaris) 〇

For the purposes of the present invention, it is understood that beneficial animals mean that animals are fed by humans for economic purposes. In particular, the more beneficial animals are yak (B〇s taurus), chicken (Gallus gaUus d〇mesticus), domestic pig (Sus cultivar), and silk sheep (Pang sheep (〇vis amm〇n Xinchuan and domesticated type of grey goose (Anser anser). Compound (v) or antioxidant, mixture or () according to the invention, σ, colorant, lipohydrate Granules or carotenoid formulations may be used to protect food and animal feed against oxidation processes that adversely affect the quality and/or shelf life of such products. However, 'compound (V) may also be used to protect animal organisms against oxidative stress and thus Maintaining or improving its health when done. Compound (7) may be added to the food or animal feed in liquid form, for example as a dispersion or as a solid &amp;&quot;, for example in a dry or cold green state, according to the total weight of the material of the invention. Or animal feed usually comprises food or animal feed, 0. 01 to 30% by weight, preferably 0. 01% by weight to 15 weight 122883.doc -115- 200816981% 'especially the car father Jia · 05 to 5 weight %, Very particularly preferred 1·1 to 2% by weight An antioxidant, mixture (μι) or (μ2), formulation, colorant, vesicle or carotenoid formulation according to the invention. The use and/or use of food and/or animal feed is familiar to the skilled artisan. Known.

It may be used together with the antioxidant, mixture (Ml) or (Μ2), product, colorant, vesicle or carotenoid formulation according to the invention or according to the method of the invention, or may be used for preparation List of specified ingredients for dermatological skin care products, medical products, food and animal feed, solids or liquids or mixtures thereof. The ingredients can be used individually or in any combination with each other. [Embodiment] / I too · σ still <v X is very invented skin medical skin care products. Too &amp;# /, the middle of the instance is called COMP·(V). For those skilled in the art, it is not necessary to use ..., pm ... times, all compounds (V) under the term C 〇 MP. (V) can be preferably used individually or in any combination of beverages. In the designated preparation. The preferred humanized D (乂) in each case is 3,3,-dihydroxyisoxanthene. Example 1 Use: COMP. (V) AI in the emulsion-〇/W type for day care 1%: % Ingredient (INCI) A 1-7 Iron stearyl ether _6, 〇·7 stearyl stearyl ether-25 122883.doc -116- 200816981 2.0 Diethylaminohydroxybenzylidene hexyl Benzoate 2.0 PEG-14 dimethylpolyoxane 3.6 hexadecanol octaol 6.0 methoxycinnamic acid ethyl hexanoic acid 2.0 dibutyl adipate B 5.0 glycerol 0.2 EDTA disodium 1.0 ubiquinone Preservative 67.8 Demineralized water (Aqua dem.) C 4.0 Caprylic/capric triglyceride, sodium acrylate copolymer D 0.2 Ascorbate sodium acetate 1.0 Tocopherol 0.2 Myrrholol 1.0 Caprylic/capric acid triglyceride Ester, sodium ascorbate, fertility network alcohol 1.0 with about 5% COMP. (V) oily solution E sufficient sodium hydroxide AI 5%: % ingredients (INCI) A 1.7 gas?, stearyl scales-6 Octadecyl alcohol 0.7 cetearyl alcohol-25 2.0 diethylamino hydroxybenzyl hexyl benzoate 2.0 PEG-14 dioxane polyoxylene 122883.doc -117- 20081 6981 3·6 hexadecanol octadecyl 6·0 methoxycinnamic acid ethylhexyl ester 2 · Dibutyl phthalate β 5.0 Glycerol 〇 2 EDTA disodium 1-〇 ubiquinol sufficient preservative 63.8 Demineralized water

C 4.0 octanoic acid/capric acid triglyceride, sodium acrylate copolymer D 0.2 ascorbic acid based sodium ruthenium acetate tocopherol 〇 2 bisabolol L0 caprylic acid/capric acid triglyceride, sodium ascorbate, tocopherol, visual The net alcohol 5·〇 has an oily solution E of about 5% COMP. (V). A sufficient amount of sodium hydroxide is prepared. The phases A and B are separately heated to about 80 ° C from each other. Phase B was stirred and homogenized in phase A. The phase c is stirred and re-homogenized in the combined phases VIII and B. Cool to about 4 Torr with stirring. 〇, add phase D, adjust the pH to about 6.5 with phase E, homogenize and cool to room temperature with stirring. Note · Prepare the formulation without a protective gas. The bottling must be carried out in an oxygen-impermeable package, such as an aluminum tube. Example 2 · COMP. (V) Use in protective arsenic _〇/w type AI 1%: 122883.doc 118- 200816981 % Ingredients (INCI) A 1.7 Record stearyl ether-6, ten Octaol 0.7 cetylstearyl ether-25 2.0 diethylaminohydroxyl-hexyl hexyl benzoate 2.0 PEG-14. monomethyl epoxidation 3.6 hexadecanol octaol 6.0 methoxycinnamic acid Ethylhexyl ester 2.0 Dibutyl adipate _ B 5.0 φ Glycerin 0.2 EDTA Disodium 1.0 Panthenol sufficient preservative 68.6 Demineralized water C 4.0 Caprylic/capric acid triglyceride, sodium acrylate copolymer D 1.0 Ascorbic acid Sodium citrate • !·0 0.2 Tocopherol acetate medicinal alcohol 1.0 Oily solution with about 5% COMP. (V) E Sufficient sodium hydroxide AI 5%: % Ingredient (INCI) A 1.7 Green earth stearyl alcohol Scale-6, octadecyl alcohol 0.7 Recording stearyl alcohol __ 2 5 2.0 Diethylamino hydroxy-decyl hexyl benzoate 122883.doc -119- 200816981 2·〇PEG-14 dimethylpolyoxyl Alkane 3·6 hexadecanol octadecyl alcohol 6,0 methoxy cinnamic acid ethylhexyl ester 2 ·0 dibutyl adipate Β 5 · 〇 glycerol

0·2 EDTA disodium ubiquinone sufficient amount of preservative 64·6 demineralized water C 4 · octanoic acid / citric acid triglyceride, sodium acrylate copolymer D 1 · 〇 ascorbic acid based acid ι 〇 acetic acid tocopherol 〇_2 Myrrholol 5·〇 Oily solution E with about 5% COMP. (V) E Sufficient sodium hydroxide preparation: Phase A &amp; B was separately heated to about 8 Torr. Hey. Phase B was mixed in phase A and homogenized. The phases are combined and the phases are combined and homogenized. Cool with stirring to about 4 (rc. Add phase D, adjust pH to about 6.5 with phase E and homogenize. Cool to room temperature with stirring. Example 3: C〇MP.(v) on face Use of cleaning lotion 〇/w type AI 1%: ^ % Ingredient (INCI) A 10.0 ethylhexanoic acid recorded stearyl ester 10 · 0 octanoic acid / citric acid triglyceride 122883.doc -120 - 200816981 1.5 Cyclopentaoxane, cyclohexyloxane 2.0 PEG-40 hydrogenated castor oil B 3.5 octanoic acid/capric acid triglyceride S, sodium acrylate total I C Tocopherol acetate ° 2 Myrrholol sufficient antiseptic Agent &amp; Essential Oil D 3_〇聚四级铵-44

°*5 Methyl sulphate cocoa triterpenic 0. 5 whale woven stearyl squama _25 2 ·0 ubiquinol, propylene glycol 4 · propylene glycol EDTA dinars 1ί0 oily solution with about 5% COMP. (V) 60 ·7 demineralized water A1 5%: % A 10.0 10.0 1.5 2.0 B 3.5 C 0.2 Ingredients (INCI) Ethylhexanoate cetyl stearyl octanoic acid / citric acid triglyceride cyclopentane oxime, ring石夕氧烧PBG_4〇Hydrogenated castor oil octanoic acid/capric acid triglyceride, sodium acrylate copolymer tocopherol medicinal alcohol 122883.doc •121· 200816981 sufficient preservative sufficient essential oil D 3.0 polytetrabasic- 44 0.5 Cocoa trimethylammonium sulfate 0.5 Cetearyl alcohol-25 2.0 Panthenol, propylene glycol 4.0 Propylene glycol 0.1 EDTA Disodium 5.0 Oily solution with about 5% COMP. (V) 56.7 Demineralized water Preparation: Dissolved Phase A. Phase B is stirred in phase A and phase C is incorporated into combined phases A and B. Dissolve phase D, stir and homogenize in combined phases A, B and C. Stir for 15 min. Example 4: Use of COMP. (V) in daily body care spray AI 1%: % Ingredient (INCI) A 3.0 Ethyl hexyl cinnamate 2.0 Diethylamino hydroxybenzyl hexyl benzoyl Acidate 1.0 polytetraammonium-44 3.0 propylene glycol 2.0 ubiquinol, propylene glycol 1.0 cyclopentaoxane, cyclohexyloxane

10.0 Octyldodecanol 0.5 PVP 122883.doc -122- 200816981 1 0.0 Caprylic/capric acid triglyceride 3.0 Benzoic acid C12-15 alkyl ester 3.0 Glycerin 1.0 Tocopherol acetate 0.3 Myrrholol 1.0 has about 5% COMP. (V) Oily Solution 59.2 Ethanol AI 5%: % Ingredient (INCI) A 3.0 Ethyloxycinnamate Ethylhexyl Ester 2.0 Diethylaminohydroxybenzylidene hexyl benzoate 1.0 Polytetraammonium-44 3.0 Propylene glycol 2.0 ubiquinol, propylene glycol 1.0 cyclopentaoxane, cyclohexyloxane

10.0 Octyldodecanol 0.5 PVP 10.0 Caprylic/capric acid triglyceride 3.0 Benzoic acid C12-15 alkyl ester 3.0 Glycerin 1.0 Tocopherol acetate 0.3 Myrrholol 5.0 Oily solution with about 5% COMP. (V) 55.2 Ethanol 122883.doc -123 - 200816981

Preparation: Weigh the components of phase A and dissolve to obtain a clear solution. Example 5: COMP. (V) Use in skin care gel AI 1%: % Ingredients (INCI) A 3.6 PEG-40 hydrogenated castor oil 15.0 ethanol 0.1 Myrrholol 0.5 Tocopherol acetate sufficient essential oil B 3.0 Acid alcohol 0.6 Carbomer 1.0 Oily solution with about 5% COMP. (V) 75.4 Demineralized water C 0.8 Triethanolamine AI 5%: % Ingredient (INCI) A 3.6 PEG-40 hydrogenated castor oil 15.0 ethanol 0.1 myrrh alcohol 0.5 tocopherol acetate sufficient essential oil B 3.0 ubiquinol 0.6 carbomer 5.0 oily solution with about 5% COMP. (V) 122883.doc -124- 200816981 71·4 demineralized water C °·8 Triethanolamine preparation·Dissolve phase A to obtain a clear solution. Phase B is expanded and phase A is agitated with phase c and homogenized in homogenized phase B. Example 6 ·· COMP. (V) Use in shaving lotion AI 1〇/〇: % Ingredients (INCI) Α ΐ〇·〇 ethylhexanoic acid cetylstearyl ester 5.0 Tocopherol acetate 1.0 No Medicinal alcohol 0.1 essential oil 0.3 Acrylate / acrylic acid C10-3 0 alkyl ester crosslinked polymer Β 15.0 ethanol 1.0 ubiquinone 3.0 glycerol 1.0 with about 5% COMP. (V) oily solution 0.1 triethanolamine 63.5 demineralized water AI 5%: % Ingredient (INCI) A 10.0 ethylhexanoic acid cetyl stearyl ester 5.0 Tocopherol acetate 1.0 Myrrholol 0.1 essential oil 122883.doc -125- 200816981 0.3 Acrylate / C10-30 alkyl acrylate crosslink Polymer B 15.0 Ethanol 1.0 Panthenol 3.0 Glycerol 5.0 Oily solution with about 5% COMP. (V) 0.1 Triethanolamine 59.5 demineralized. Water preparation: component of mixed phase A. Phase B was dissolved, incorporated into phase A and homogenized. Example 7: Use of COMP. (V) in after-sun lotion AI 1%: % Ingredient (INCI) A 0.4 Acrylate/Acrylic C10-3 Oxyl ester cross-linked polymer 15.0 Ethylhexanoic acid Whale hard fat Base ester 0.2 Myrrholol 1.0 Tocopherol acetate sufficient amount of essential oil B 1.0 Pantosan 15.0 Ethanol 3.0 Glycerin 1.0 Has about 5% COMP. (V) oily solution 63.2 Demineralized water C 0.2 Triethanolamine AI 5%: 122883. Doc -126- 200816981 % Ingredients (INCI) A 0.4 Acrylate / Acrylic Acid C10-3 0 Alkyl Crosslinking Polymer 15.0 Ethylhexanoic Acid Recording Hard Laryl Ester 0.2 Myrrholol 1.0 Tocopherol Acetate A sufficient amount of essential oil B 1.0 Pantothenic acid 15.0 Ethanol 3.0 Glycerol 5.0 Oily solution with about 5% COMP. (V) 59.2 Demineralized water C 0.2 Triethanolamine Preparation: Component of mixed phase A. Phase B was stirred in phase A under homogenization. Neutralize with phase C and homogenize again. Example 8: Use of COMP. (V) in sunscreen lotion AI 1%: % Ingredient (INCI) A 4.5 Ethylhexyl methoxycinnamate 2.0 Diethylaminohydroxyl-decylhexyl benzoate 3.0 Octolide 2.5 Malic acid di-C12-13 alkyl ester 0.5 Tocopherol acetate 4.0 Polyglyceryl-3 methyl glucose distearate B 3.5 Isophthalic acid recorded stearyl ester 122883.doc -127- 200816981 1.0 VP/Eicocarbene Copolymer 5.0 Iso-hexadecane 2.5 Malic acid di-C12-13 alkyl ester 3.0 Titanium dioxide, tridecyloxyoctyldecane C 5.0 Glycerin 1.0 Cetearyl sulfate sodium 0.5 Sanxianjiao 59.7 Mineral water D 1.0 has an oily solution of about 5% COMP. (V) 1.0 phenoxyethanol, methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, butyl p-hydroxybenzoate, propyl p-hydroxybenzoate, Isobutyl p-hydroxybenzoate 0.3 Pascalol AI 5%: % Ingredient (INCI) A 4.5 Ethyl hexyl cinnamate 2.0 Diethylamino hydroxybenzyl hexyl benzoate 3.0 Occidental Lin 2.5 malic acid di-C12-13 alkyl ester 0.5 tocopherol acetate 4.0 polyglyceryl-3 methyl glucose distearate B 3.5 isophthalic acid Wax stearyl ester 1.0 VP / eicosene copolymer 5.0 isohexadecane 122883.doc -128- 200816981 2.5 Malic acid di-C12-13 alkyl ester 3.0 Titanium dioxide, trimethoxyoctyl decane C 5.0 Glycerin 1.0 Cetyl wax Sodium stearyl sulfate 0.5 Sanxianjiao 55.7 demineralized water D 5.0 Oily solution with about 5% COMP. (V) 1.0 phenoxyethanol, hydroxy hydroxybenzoate, ethyl p-hydroxybenzoate, Preparation of butyl p-hydroxybenzoate, propionate p-hydroxybenzoate, isobutyl p-hydroxybenzoate 0.3 Bisphenol. The components of phases VIII and 3 were separately heated to about 8 Torr. Phase B was stirred and homogenized in phase A. The phase c is heated to about 8 (Γ: and stirred under combined conditions in the combined phase human and B. Cooled to about 40 ° C with stirring, phase D is added and homogenized again. φ Example 9 Use of C〇MP.(V) in sunscreen lotion_〇/w type AI 1%: 〇/〇 component (INCI) A 2.0 cetearyl alcohol _6, stearyl alcohol 2·0 cetyl stearin Alcohol ether - 25 3 · 〇甘' from Ershan oxalic acid 2 2 〇 醇 醇 十八 octadecyl alcohol 2,0 ethyl hexanoate cetyl stearyl ester 5 · methoxy cinnamic acid ethylhexyl ester 122883.doc -129- 200816981

1.0 Ethylhexyl triazinone 1.0 VP/eicene copolymer 7.0 Isopropyl octanoate B 5.0 Zinc oxide, triethoxyoctyl decane C 0.2 Sanxian gum 0.5 Hydroxyethyl acrylate / propylene sulfonate II Sodium methyl taurate copolymer, squalane, polysorbate 60 0.2 EDTA disodium 5.0 Propylene glycol 0.5 Pantothenic acid 60.9 Demineralized water D 1.0 Oily solution with about 5% COMP. (V) 0.5 Phenoxyethanol , p-hydroxyphenyl decanoate, butyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, propyl p-hydroxybenzoate, isopropyl p-hydroxybenzoate 1.0 Tocopherol acetate 0.2 Myrrholol AI 5%: % Ingredients (INCI) A 2.0 Cetearyl alcohol-6, stearyl alcohol 2.0 Cetearyl alcohol-25 3.0 Glycerol tribehenate 2.0 Cetyl stearyl alcohol 2.0 Ethylhexanoic acid cetyl stearate Ester 122883.doc -130- 200816981 Ethyloxycinnamate Ethylhexyl Ethylhexyl Triterpene with VP/Eicocarbene Copolymer Tetrapropanoic Acid Oxide Oxidation, Diethoxyoctyl Chopping Sanxian Gum hydroxyethyl acrylate/propylene decyl dimethyl taurine steel copolymer, Squalane, polysorbate 60 EDTA disodium propylene glycol ubiquinone 56.9 demineralized water 5 · 〇 with about 5% COMP. (V) oily solution phenoxyethanol, methylparaben, p-base Preparation of butyl benzoate, ethyl p-hydroxybenzoate, p-hydroxybenzoic acid lactone, isopropyl p-hydroxybenzoate, and probiotics: heat phase A to about 80 ° C, stir in phase B and Homogenization for 3 min. Similarly, phase c was heated to 80 ° C and stirred in the combined phases A and B under homogenization. Cool to about 40 ° C, stir in phase D and homogenize again. Example 10: Use of COMP. (V) in sunscreen lotion-0/W type AI 1%:

B C

D 5.01.0 1.0 7.0 5.0 0.2 0.50.2 5.0 0.5 〇·: 1.00.2 122883.doc -131 - 200816981 % Ingredients (INCI) A 3.5 Whale stearyl scales, octadecyl alcohol 1 · 5 Su% hard fat Alcohol scales _ 2 5 7.5 methoxy cinnamic acid ethylhexyl ester 2.0 diethylamino hydroxy benzyl benzyl benzoyl benzoate 2.0 cyclodecane oxane, cyclohexanoxane 0.5 beeswax 3 · 0 hexadecanol Octadecanol

10.0 caprylic acid/capric acid triglyceride Β 5.0 Titanium dioxide, vermiculite, bismuth polyoxyalkylene, alumina C 3.0 glycerol 0.2 EDTA disodium 0.3 Sanxian gum 1 · thioglycoside 2.0 ubiquinol, propylene glycol 56.3 demineralization Water D 1.0 has an oily solution of about 5% C〇MP. (V) 1.0 Tocopherol acetate 0.2 Myrrhicol A sufficient amount of essential oils sufficient amount of preservative AI 5%: % Ingredients (INCI) A 3.5 Cetearyl alcohol ether _6, octadecyl alcohol 122883.doc -132- 200816981 1.5 Cetearyl alcohol-25 7.5 Ethyl hexyl methoxycinnamate 2.0 Diethylamino hydroxybenzyl hexyl benzoate 2.0 cyclopentane Oxane, cyclohexanoxane 0.5 beeswax 3.0 cetyl stearyl alcohol 1 〇 · 0 octanoic acid / citric acid triglyceride B 5.0 Titanium dioxide, vermiculite, polymethyl siloxane, alumina C 3.0 glycerol 0.2 EDTA Disodium 0.3 Sanxianjiao 1.0 Glycosylglycan 2.0 Panthenol, Propylene Glycol 52.3 Demineralized Water D 5. 〇 Oily solution with about 5% COMP. (V) 1.0 Vitamin ageing 〇, 2 Myrrhicol Full amount of essential oil Preparation of a sufficient amount of preservative: Phase A was heated to about 80 ° C, stirred in phase B and homogenized for 3 min. Similarly, phase C was heated to 80 ° C and mixed in the combined phases A and B under homogenization. Cool to about 40. 〇, stir in phase D and homogenize again. Example 11: Use of COMP. (V) in foot cream 122883.doc -133- 200816981 AI 1%: % Ingredient (INCI) A 2.0 Recorded stearyl ether-6, stearyl alcohol 2.0 Whale hard fat Alcohol ether-2 5 5.0 Ethylhexanoate cetylstearyl ester 4.0 Cetyl alcohol 4.0 Glyceryl stearate 5.0 Mineral oil • 02 0.5 Menthol camphor B 69.3 Demineralized water sufficient preservative C 1.0 Myrrholol 1.0 Tocopherol acetate D 1.0 Oily solution with about 5% COMP. (V) 5.0 AI 5%: Witch hazel extract% Ingredients (INCI) A 2.0 Cetearyl alcohol-6, stearyl alcohol 2.0 Whale Wax Stearyl Ether-25 5.0 Ethylhexanoate whale, stearyl ester 4.0 Whale sterol 4.0 Stearic acid glyceride 5.0 Mineral oil 122883.doc -134- 200816981 0.2 Menthol sputum · 5 Rod brain B 65.3 off Mineral water sufficient amount of preservative c 1.0 Myrrholol 1.0 Tocopherol acetate D 5.0 Oily solution with about 5% COMP. (V) 5. Preparation of witch hazel extract from North Korea: Groups of phases A and B separately from each other The heating is divided to about (10) work. Phase B was mixed in phase A under homogenization. Cool to about 4 Torr with stirring. 〇, add phases C and D and briefly homogenize. Cool to room temperature with stirring. Example 12: Use of COMP. (V) in a W/0 emulsion with bisabolol AI 1%: % Ingredient (INCI) A 6.0 PEG-7 hydrogenated castor oil 8·0 ethylhexanoic acid cetyl stearyl Ester 5.0 isopropyl myristate 1 5.0 Mineral oil 0.3 Magnesium stearate 0.3 Aluminum stearate 2·0 PEG-45/dodecan diol copolymer B 5.0 Glycerol 0.7 Magnesium sulfate 5 5 · 6 demineralized water 122883.doc -135 - 200816981 C 1.0 Oily solution with about 5% COMP. (V) 0.5 Tocopherol acetate 0.6 Myrrhicol AI 5%: % Ingredients (INCI) A 6.0 PEG-7 hydrogenated castor oil 8.0 Ethyl Acid cetyl stearyl ester 5.0 tetradecylic acid isopropyl ester 1 5.0 mineral oil 0.3 magnesium stearate 0.3 aluminum stearate 2.0 PEG-45/dodecan diol copolymer B 5.0 glycerol 0.7 magnesium sulfate 5 1 · 6 Demineralized water C 5.0 Oily solution having about 5% COMP. (V) 0.5 Tocopherol acetate preparation: Phases A and B were separately heated to about 85 ° C from each other. Phase B was stirred and homogenized in phase a. Cool to about 4 ° C with stirring, add phase c and homogenize briefly again. Cool to room temperature with stirring. List of Formulations for the Patented Keratin Binding Domain_Hair Care Example 13: Foam Conditioner AI with Styling Agent AI 1% % Ingredient (INCI) 122883.doc -136- 200816981 A 10.0 PVP/VA Copolymer 0,2 Hydroxyethyl methacrylate cetyl diammonium 0.2 cetearyl alcohol-25 0.5 dimethoxane copolyol sufficient essential oil 10.0 ethanol 1.0 oily solution with about 5% COMP. (V) 68.1 demineralized water I 10.0 Propylene / Dilute AI 5% % Ingredients (INCI) A 10.0 PVP/VA Copolymer 0,2 Hydroxyethyl methacrylate cetyl diammonium 0.2 Cetearyl alcohol-25 0.5 Dimethyl phthalate Copolyol φ sufficient essential oil 10.0 ethanol 5.0 oily solution with about 5% COMP. (V) 6 4.1 demineralized water 10.0 propane / butane preparation: the components of phase A are weighed together, stirred until all the substances are dissolved and Bottling. Example 14: Foam Modifier AI 1% 122883.doc -137 - 200816981 % Ingredient (INCI) A 1.0 Poly Quaternary - 4 0.5 Hydroxyethylethyl cetyl dimethylammonium 1.0 has about 5% COMP. (V) Oily solution sufficient amount of essential oils sufficient amount of preservatives 91.5 demineralized water 6.0 propane / butane AI 5% % ingredients (INCI) A 1.0 poly quaternary ammonium-4 0.5 hydroxyethyl methacrylate cetyl diammonium ammonium 5.0 About 5% COMP. (V) oily solution sufficient amount of essential oils sufficient preservatives 87.5 demineralized water 6.0 propylene / butyl burning preparation: the components of phase A are weighed together, stirred until all the substances are dissolved to obtain a clear solution And bottling. Example 15: Foam Modifier AI 1% % Ingredient (INCI) A 1.0 Polytetra-ammonium-11 0.5 Hydroxyethyl methacrylate cetyl dimethyl ammonium 122883.doc -138- 200816981 1.0 with approximately 5% COMP. (V Oily solution sufficient amount of essential oils sufficient amount of preservative 91.5 demineralized water 6.0 propane / butane A1 5% % Ingredients (INCI) A 10 polytetraammonium-11 0.5 hydroxyethyl methacrylate cetyl diammonium ammonium 5.0 Oily solution with about 5% COMP. (V) sufficient amount of essential oil sufficient amount of preservative 87.5 demineralized water 6.0 propylene / diced preparation: the components of phase A are weighed together, stirred until all substances dissolve to obtain clarification Solution and bottling. Example 16: Styling Foam AI 1% % Ingredient (INCI) A 0.5 Lauryl Ether-4 Full Flavor Essential Oil B 77.3 Demineralized Water 1 0 · 0 Poly Quaternary 4 An-2 8 1.0 with approximately 5% COMP. (V Oily solution 122883.doc -139- 200816981 0.5 Dimethoxane copolyol 0.2 Cetearyl alcohol-25 0.2 Panthenol 0.1 PEG-25 PABA 0.2 Hydroxyethyl cellulose C 10.0 HFC 152 A AI 5% % ingredients (INCI)

A 0.5 lauryl ether-4 sufficient essential oil B 73.3 demineralized water 10.0 polytetrabasic ammonium-28 5.0 oily solution with about 5% COMP. (V) 0.5 dioxon polyoxyalkylene copolyol 0.2 cetyl hard fat Alcohol ether-25 0.2 ubiquinol

0.1 PEG-25 PABA 0.2 hydroxyethyl cellulose

C 10.0 HFC 152 A Preparation: 'Components of Mixed Phase A. The components of phase B were added in sequence and dissolved. Bottled with phase C. Example 17: Styling Foam AI 1% % Ingredient (INCI) 122883.doc -140- 200816981 A 2,0 Cocoa Trimethylammonium Sulfate A sufficient amount of essential oil B 78.5 Demineralized water 6.7 Acrylate copolymer

0.6 AMP 1.0 oily solution with approximately 5% COMP. (V) 0.5 dioxonium copolyol copolyol 0.2 cetearyl alcohol-25 ^ 0.2 ubiquinol

0.1 PEG-25 PABA 0.2 hydroxyethyl cellulose

C 10.0 HFC 152 A AI 5% % Ingredients (INCI) A 2.0 Cocotrimethylammonium sulfate 0 A sufficient amount of essential oil B 74.5 Demineralized water

6.7 Acrylate Copolymer 0.6 AMP 5.0 Oily solution with about 5% COMP. (V) 0.5 Dimethoxane copolyol 0.2 Cetearyl alcohol-25 0.2 Panthenol 0.1 PEG-25 PABA 122883.doc -141 - 200816981

0.2 Hydroxyethyl Cellulose C 10.0 HFC 152 A Preparation: Component of Mixed Phase A. The components of phase B were added in sequence and dissolved. Bottled with phase C. Example 18: Styling foam AI 1% % Ingredient (INCI) A 2.0 Methyl sulphate cocoa triammonium sufficiency essential oil B 7.70 Poly quaternary ammonium -44 1.0 Oily solution with about 5% COMP. (V) sufficient antiseptic Agent 79.3 Demineralized water C 10.0 Propane / Butane AI 5% % Ingredients (INCI) A 2.0 Methyl sulphate cocoa triammonium sufficiency essential oil B 7.70 Poly quaternary ammonium -44 5.0 with about 5% COMP.(V) Oily solution sufficient amount of preservative 75.3 Demineralized water C 0.0 Propylene / Dilute Preparation: Mixture A component. The component of phase B was dissolved to obtain a clear solution of 122883.doc-142-200816981, followed by phase B in phase A. The pH was adjusted to 6-7 and bottled with phase C. Example 19: Styling Foam AI 1% % Ingredients (INCI) A 2.00 Cocoa Triammonium Sulfate Sufficient Essential Oil B 72.32 Demineralized Water

2.00 VP/acrylate/lauryl methacrylate copolymer 0.53 AMP 1.00 oily solution with about 5% COMP. (V) 0.20 cetearyl ether-25 0.50 ubiquinol 0.05 benzophenone-4 0.20 amine Keshimonone Chloride, Cetrimonium Chloride, Triterpene Polyether-12 15.00 Ethanol C 0.20 Hydroxyethyl Cellulose D 6.0 0 Propylene / Ding AI 5% % Ingredient (INCI) A 2.00 Methyl Cocoa triammonium sulfate, sufficient amount of essential oil B 68.32 demineralized water 122883.doc -143- 200816981

2.00 VP/acrylate/lauryl methacrylate copolymer 0.53 AMP 5.00 oily solution with about 5% COMP. (V) 0.20 cetearyl ether-25 0.50 ubiquinol 0.05 benzophenone-4 0.20 amine Base ketone oil, cetrimonium chloride, triterpene alcohol scaly-12 15.00 ethanol C 0.20 hydroxyethyl cellulose D 6.00 propane / butane preparation: component of mixed phase A. The components of phase 8 were added in sequence and dissolved to dissolve phase C in a mixture of A and B. The pH was then adjusted to 7 and phase D to start bottling. Example 20: Styling Foam AI 1% % Ingredient (INCI) A 2.00 West Qu-Chlorin Ammonium Essential Oil B 67.85 Demineralized Water 7.00 Polytetra-ammonium-46 1.00 Oily Solution with About 5% COMP. (V) 0.20 Whale Wax stearyl ether-25 0.50 tyrosol 〇. 〇 5 benzophenone-4 122883.doc -144- 200816981 0·20 amino fluorenone oil, cetrimonium chloride, triterpene polyether 42 Η. ΟΟEthanol C 0·20 Hydroxyethyl Cellulose D 6·〇〇 Propane/Butane AI 5% % Ingredient (INCI) Α 2·〇〇西曲气铵 Full amount of essential oil Β 63·85 Demineralized water 7· 〇〇 poly quaternary ammonium -46 5 · 〇〇 with about 5% COMP. (V) oily solution 0 · 20 cetyl stearyl ether - 25 0 · 5 ubiquinol 〇 · 〇 5 benzophenone -4 〇*2 guanidinyl ketone oil, cetrimonium chloride, triterpene alcohol poly b. OO ethanol C 〇.2 〇 by ethyl cellulose D 6 · 〇〇 propane / butane preparation: mixed phase A Component. The components of phase B were added in sequence and dissolved. Phase C was dissolved in a mixture of a and B, and then the pH was adjusted to. Bottled with phase D. Example 21: Styling foam AI 1% % Ingredient (INCI) 122883.doc -145 - 200816981 A Sufficient PEG-40 hydrogenated castor oil sufficient essential oil 85·5 demineralized water Β 7·〇 polystyrene sulfonate 1.0 Oily solution with about 5% COMP. (V) 5·5 Cetrimonium Bromide A sufficient amount of preservative c 6_〇propane / butane • Styrofoam AI 5% % Ingredients (INCI) A Sufficient PEG -40 hydrogenated castor oil sufficient essential oil 815 demineralized water B 7·0 sodium polystyrene sulfonate φ 5,0 with about 5% COMP. (V) oily solution 〇 · 5 citrolan bromide sufficient preservative C 6·0 propane / butane ▲ preparation · dissolve phase A. Phase β was weighed into phase a and dissolved to give a clear solution. Adjust the pH to 6-7 and bottle with phase c. Example 22: Styling foam AI 1% % Ingredient (INCI) 122883.doc -146- 200816981 A Sufficient PEG-40 hydrogenated castor oil sufficient essential oil 92.0 demineralized water B0.5 polytetrabasic-10 1.0 with about 5 % COMP.(V) oily solution 0.5 cetrimonium bromide sufficient preservative C 6.0 propylene/butadiene AI 5% % Ingredients (INCI) A sufficient PEG-40 hydrogenated castor oil sufficient essential oil 88.0 demineralized water B 0.5 polytetra-ammonium-10 5.0 oily solution with about 5% COMP. (V) ^ 0.5 cetrimonium bromide sufficient preservative C 6.0 Propylene / butadiene Preparation: Dissolve phase A. Phase B was weighed into phase A and dissolved to give a clear solution. The pH was adjusted to 6-7 and bottled with phase C. Example 23: Styling foam AI 1% % Ingredients (INCI) A Sufficient PEG-40 hydrogenated castor oil 122883.doc • 147- 200816981 sufficient essential oil 82.5 demineralized water B 10.0 polytetra-ammonium-16 1.0 with about 5% Oily solution of COMP.(V) 0.5 Hydroxyethyl methacrylate cetyl dimethyl ammonium sufficient preservative C 6.0 Propane/butane AI 5% % Ingredients (INCI) A Sufficient PEG-40 hydrogenated castor oil Essential oil 78.5 Demineralized water B 10.0 Poly quaternary ammonium-16 5.0 Oily solution with about 5% COMP. (V) 0,5 Hydroxyethyl methacrylate cetyl dimethyl ammonium sufficient preservative C 6.0 Propane / butane Preparation: Dissolve phase A. Phase B was weighed into phase A and dissolved to give a clear solution. The pH was adjusted to 6-7 and bottled with phase C. Example 24: Styling Foam AI 1% % Ingredient (INCI) A 2.0 Cocotrimethylammonium Sulfate A sufficient amount of essential oil 122883.doc -148 - 200816981 B 84.0 Demineralized Water 2.0 Polyglucosamine

1.0 Oily solution with about 5% COMP. (V) 0.5 dimethyl polyoxyl copolyol 0.2 cetearyl alcohol-25 0.2 ubiquinone 0.1 PEG-25 PABA C 10.0 HFC 152 A AI 5% % (INCI) A 2.0 Sulfhydryl Sulfate Trimethylammonium Sufficient Essential Oil B Glucosamine

5.0 Oily dissolved gas having about 5% COMP. (V) 0.5 dimethyl polyoxyl copolyol 0.2 cetearyl alcohol-25 0.2 ubiquinone 0.1 PEG-25 PABA C 10.0 HFC 152 A Preparation: mixed phase The component of A. The components of phase B were added in sequence and dissolved. Bottled with phase C. Example 25: Care shampoo AI 1% % Ingredients (INCI) 122883.doc -149- 200816981 A 30.0 Sodium lauryl ether sulfate 6.0 Cocoamphoacetate 6.0 Cocoa propyl propyl betaine 3.0 Sodium lauryl ether sulfate , ethylene glycol distearate, coconut decylamine MEA, lauryl ether-10 1.0 oily solution with about 5% COMP. (V) 7.7 poly quaternary ammonium-44 2.0 amino fluorenone oil | Essential oils Preservatives 1.0 Sodium chloride 43.3 Demineralized water B Sufficient citric acid AI 5% % Ingredients (INCI) φ A 30.0 Sodium lauryl ether sulfate 6.0 Cocoamphoacetate 6.0 Cocoa propyl propyl betaine 3.0 Sodium lauryl ether sulfate, ethylene glycol distearate, cocoamine MEA, lauryl ether-10 5.0 oily solution having about 5% COMP. (V) 7.7 polytetra-ammonium-44 2.0 amino fluorenone Oil sufficient amount of essential oil 122883.doc -150- 200816981 sufficient preservative 1.0 sodium chloride 39.3 demineralized water B sufficient amount of citric acid preparation: mixed phase A components and dissolved. The pH was adjusted to 6-7 with citric acid. Example 26: Shower gel AI 1% % Ingredient (INCI) A 40.0 Sodium lauryl ether sulfate 5.0 Glycosyl glucoside 5.0 Cocoa propyl propyl betaine 1.0 Oily solution with about 5% COMP. (V) 1.0 Ubiquinone Alcohol sufficient essential oil sufficient preservative 2.0 Sodium chloride 46.0 demineralized water B sufficient citric acid AI 5% % Ingredients (INCI) A 40.0 Sodium lauryl ether 5.0 癸 glucoside 5.0 Cocoa propyl lysine Alkali 122883.doc -151 - 200816981 5.0 Oily solution with about 5% COMP. (V) 1.0 Panthenol sufficient amount of essential oils sufficient preservatives 2.0 Sodium chloride 42.0 Demineralized water B Sufficient citric acid preparation: Mixed phase Component A and dissolved. The pH was adjusted to 6-7 with citric acid. Example 27: Shampoo

AI 1% % A 40.0 5.0 5.0 Sufficient 0.1 Ingredients (INCI) Sodium lauryl ether sulfate C12 -15 plucking oil puzzles-15 Sustained sodium glucosides essential oils Triethylene glycol 44.6 Demineralized water 1.0 with about 5% COMP (V) oily solution 0.3 polytetrabasic-10 1.0 ubiquinol sufficient preservative 1.0 lauryl ether-3 2.0 sodium chloride 122883.doc -152- 200816981 AI 5% % ingredient (INCI) A 40.0 Laurel Sodium alcohol ether sulfate 5.0 Cl2-15 palm oil ether-15 sulfonate 5.0 癸 糖 glycoside sufficient essential oil 0.1 phytotriol 40.6 demineralized water

5.0 Oily solution with about 5% COMP. (V) 0.3 Poly quaternary 4 amp 1 0 1.0 ubiquinol sufficient amount Preservative 1.0 Lauryl ether-3 2.0 sodium chloride Preparation: Mix the components of phase A and dissolve. The pH was adjusted to 6-7 with citric acid. Example 28: Shampoo AI 1% % Ingredients (INCI) A 15.00 CocoApropyl propyl betaine 1 0.00 Cocoamphodiacetate disodium 5.00 Polysorbate 20 5.00 Indole glycoside sufficient essential oil 122883. Doc -153 - 200816981 A sufficient amount of preservative L〇〇 has an oily solution of about 5% COMR(V). 0·15 guar hydroxypropyltrimethylammonium chloride 2-00 lauryl ether-3 58.00 demineralized water Sufficient amount of citric acid Β 3 · 〇〇 PEG-150 distearate AI 5%

/〇 ingredients (INCI) A 15 · cocoa decyl propyl betaine 1 〇. 〇〇 coconut oil amphoteric diacetate disodium 5 〇〇 polysorbate 20 5 · 〇〇. 癸 glycoside sufficient Essential oils Preservatives 5.00 have an oily solution of about 5% COMP. (V) 0 · 1 5 guar hydroxypropyl trimethyl ammonium chloride 2-〇〇 lauryl ether · 3 54·00 demineralized water A sufficient amount of bismuth citrate 3·〇〇PEG-150 distearate is intended to be 6-7. Add Preparation: Weigh the components of phase A and dissolve. The pH was adjusted by adding phase B and heating to about 50 °C. Cool to room temperature with stirring. Example 29: Humidifying body cream I22883.doc -154- 200816981 AI 1% % Ingredient (INCI) A 2.0 Cetearyl alcohol-25 2.0 Recording wall Stearyl ether-6, stearyl alcohol 3.0 Ethyl Acid cetyl stearyl ester 1.0 Dioxane polyoxane 4.0 Cetyl alcohol octadecyl alcohol 3.0 Stearic acid glyceride SE 5.0 Mineral oil 4.0 Simmondsia Chinensis (Holly 3.0 mineral oil, lanolin alcohol B 5.0 Propylene glycol 1.0 Oily solution with about 5% COMP. (V) 1.0 Panthenol 0.5 Magnesium aluminum lanthanum sufficient preservative 65.5 Demineralized water C sufficient essential oil D sufficient amount of citric acid AI 5% % Ingredients (INCI A 2.0 cetearyl alcohol-25 2.0 fish hexavinyl stearyl ether-6, octadecyl alcohol 3.0 ethyl hexanoic acid 躐 stearyl ester I22883.doc -155- 200816981 1.0 4.0 3.0 5.0 Acetalane hexadecanol octadecyl stearyl stearate broken oil 4.0 Wax yellow (jojoba) seed oil 3.0 broken oil, lanolin alcohol Β 5 · 0 propylene glycol 5.0 with about 5% COMP. (V) Oily solution

1.0 ubiquinol 0.5 magnesium magnesium citrate sufficient preservative 61.5 demineralized water C sufficient amount of essential oil D sufficient amount of citric acid preparation · separately heating phase A and B to about 8 ° ° C. Briefly phase B

Qualitative, then phase B was stirred in phase A and homogenized again. Cool to the machine, add phase C and fully homogenize again. Adjust the pH to 6.7 〇KM with citric acid. Q: Humidifying body cream AI 1% 〇/〇 component (INCI) A 6·0 PEG-7 hydrogenated castor oil 10-decylhexanoic acid cetyl Stearyl ester 5% isopropyl myristate 122883.doc • 156- 200816981 7.0 Mineral oil 0.5 Milk oil (Butyrospermum Parkii) 0.5 Aluminum stearate 0.5 Magnesium stearate 0.2 No Medicinal alcohol 0.7 four-stage plate? -18- Belletite B 5.0 Dipropylene glycol 0.7 Magnesium sulfate sufficient preservative 62.9 Demineralized water C sufficient essential oil 1.0 with about 5% COMP. (V) oily solution AI 5% % Ingredients (INCI) A 6.0 PEG -7 hydrogenated castor oil 10.0 ethylhexanoic acid cetyl stearyl ester 5.0 isopropyl myristate 7.0 mineral oil 0.5 milk oil ( shea butter) 0.5 aluminum stearate 0.5 magnesium stearate 0.2 myrrh Alcohol 0.7 Grade 4 4A _ 18 - Bell ^ Polystone B 5.0 Dipropylene glycol 122883.doc -157- 200816981 0.7 Magnesium sulfate sufficient preservative 58.9 Demineralized water C sufficient essential oil 5.0 with about 5% COMP. (V) Preparation of oily solution: Phases A and B were separately heated to about 80 °C. Phase B was stirred and homogenized in phase A. Cool to about 40 ° C with stirring, add phase c and homogenize again. It was allowed to cool to room temperature with stirring. Example 31: Foundation - 〇 / w type ΑΙ 1% % Ingredients (INCI) A 2.0 Cetearyl alcohol-6, stearyl alcohol 2.0 Cetearyl alcohol-25 6.0 Stearic acid glycerin 1.0 Green soil Alcohol 8.0 Mineral oil 7.0 Ethylhexanoic acid Green sulphuric acid vinegar 0.2 One smectite oxylate B 3.0 Propylene glycol 1.0 Panthenol sufficient preservative 61·9 demineralized water C 0.1 Myrrholol 1.0 has about 5% Oily solution of COMP.(V) 122883.doc -158 - 200816981 A sufficient amount of essential oil D 5.7 CI 77 891, titanium dioxide 1.1 Iron oxide AI 5% % Ingredient (INCI) A 2.0 Cetearyl alcohol-6, 18 Alcohol 2.0 cetearyl alcohol-25 6.0 stearic acid glyceride 1.0 whale oxalate 8.0 mineral oil 7.0 ethyl hexanoic acid cetyl stearyl ester 0.2 dimethyl polyoxy siloxane B 3.0 propylene glycol 1.0 ubiquinol Preservative 57.9 demineralized water c 0.1 Myrrhicol 5·〇 has about 5% COMP. (V) oily solution sufficient amount of essential oil D 5.7 C· L 77 891, titanium dioxide 1.1 iron oxide, preparation · separate phase eight And B is heated to about 80. Hey. Phase B was stirred in phase A and homogenized A. Cool down to about (10) after falling off. C, add the phase. And again, the knife is flattened. It was allowed to cool to room temperature with stirring. 122883.doc -159- 200816981 Example 32: In the following test, a dermatological skin care product according to the present invention comprising Compound (V) prepared according to Example 1 is described. This compound (V) is referred to as COMP. (V) in the following examples. As a preferred compound of COMP_(V), 3,3i-dihydroxyisoxanthene is used. It will be understood by those skilled in the art that all other specified compounds of COMP. (V) can also be prepared according to Example 1 and used in the formulations specified below. Designated COMP. (V) is used in solid form. The following data is in parts by weight

Number 0 Cleansing shampoo ingredients (INCI) 1 2 3 4 5 Sodium lauryl ether sulfate 13.00 15.00 10.50 12.50 10.00 Cocoa propyl propyl betaine 7.50 7.00 5.00 5.50 10.00 PEG-7 cocoglyceride 2.00 2.50 3.50 5.00 2.30 Essential Oil 0.10 0,10 0.10 0.10 0.10 COMP.(V) 1.0 5.0 0.1 0.5 10.0 D-Pantanol USP 1.00 1.50 L80 1.70 1.40 Preservative 0.10 0.10 0.10 0.10 0.10 Citric Acid 0.10 0.10 0510 0.10 0.10 Luviquat® Ultra Care 1.50 1.00 L50 1.20 1.10 Sodium Chloride 1.50 1.40 1.40 1.30 1.50 Demineralized water to make up 100 to make up 100 to make up 100 to make up 100 to make up 100 shampoo ingredients (INCI) 1 2 3 4 5 sodium lauryl ether sulfate 35.00 40.00 30.00 45.00 27.00 5.00 5.50 4.90 3.50 7.00 Cocoa propyl propyl betaine 10.00 5.00 12.50 7.50 15.00 Essential oil 0.10 0.10 0.10 0.10 0.10 COMP. (V) 1.0 5.0 0.1 0.5 10.0 D-ubiquinone USP 0.50 1.00 0.80 1.50 0.50 Preservative 0.10 0.10 0.10 0.10 0.10 Citric acid 0.10 0.10 0.10 0.10 0.10 Lauryl ether-3 0.50 2.00 0.50 0.50 2.00 122883.doc -160- 200816981

Sodium chloride ___ demineralized water cleansing conditioning shampoo

Foam o/w emulsion

Emulsion 1 Emulsion 2 Heavy-Li % % by volume Weight % Volume 0/〇5 Acid: 5^00 1.00 Cetyl alcohol 5j 〇 hexadecanol octanol 2.00 PEG-40 stearate 8.50 PEG-20 stearic acid Ester 1.00 octanoic acid / citric acid triglyceride 4 Ό 0 &quot; 2.00 benzoic acid C12-15 alkyl ester To.oo 15.00 Cyclodecyl polyoxy siloxane Too ~ dioxane polyoxane 0.50 COMP. (V) 5.0 10.0 Ethylhexyl citrate 5.00 Tetradecyltetradecanoate Z00 Ground wax T50 ~ Glycerol 3.00 Hydroxypropyl phosphate Too ' 3.50 BHT 0.02 EDTA Erina 〇 3〇_ ' 0.10 Essential oils, preservatives sufficient The amount of potassium hydroxide in the foot is sufficient. I22883.doc -161 - 200816981 Demineralized water to make up 100 to make up 100 Adjust the pH to 6.5-7.5 Adjust the pH to 5.0-6.0 Emulsion 1 70 Emulsion 2 35 Nitrogen 30 Propane / Butadiene 65 Conditioning shampoo with pearl powder 1 2 3 Polytetramine-10 0.50 0.50 0.40 Sodium lauryl ether sulfate 9.00 8.50 8.90 Cocoa propyl propyl betaine 2.50 2.60 3.00 Uvinul® MS 40 1.50 0.50 1.00 CO MP.(V) 1.0 5.0 0.5 Pearl powder solution 2.00 2.50 EDTA Erna 0.10 0.15 0.05 Preservative, essential oil, thickener sufficient amount sufficient amount sufficient demineralized water to make up 100 to make up 100 to make up 100 to adjust the pH to 6.0

Cleansing Shampoo 1 2 3 Polytetramine-10 0.50 0,50 0.50 Sodium lauryl ether sulfate 9.00 8.50 9.50 COMP.(V) 5.0 0.1 3.0 Uvinul Μ® 40 1.00 1.50 0.50 Preservative, essential oil, thickening Sufficient enough amount of sufficient demineralized water to make up 100 to make up 100 to make up 100 to adjust pH to 6.0 cleansing conditioning shampoo with volume effect 1 2 3 sodium lauryl ether ether 10.00 10.50 11.00 Uvinul® MC 80 2.00 1.50 2.30 COMP (V) 10.0 0.1 0.5 Cocoa-propyl propyl betaine 2.50 2.60 2.20 EDTA di-nano 0.01 0.10 0.01 Preservative, essential oil, thickener, sufficient amount of sufficient demineralized water to make up 100 to make up 100 to make up 100 to pH Value adjusted to 6.0 122883.doc -162- 200816981 Gel Cream

1 2 3 4 Acrylate/C10-30 alkyl acrylate crosslinked polymer 0.40 0.35 0.40 0,35 Carbomer 0.20 0.22 0.20 0.22 Sanxianjiao 0.10 0.13 0.10 0.13 Cetyl stearyl alcohol 3.00 2.50 3.00 2.50 Benzoic acid C12 -15 alkyl ester 4.00 4.50 4.00 4.50 octanoic acid/capric acid triglyceride 3.00 3.50 3.00 3.50 Uvinul® APWm 2.00 1.50 0.75 1.00 UvaSorb® k2A ethylhexyl bis-isoamylbenzoxazolyl phenyl melamine 3.00 Uvirnil® MC 80 3.00 1.00 Bis-ethylhexyloxyphenol decyloxy phenyl triazine 1.50 2.00 Butyl methoxydibenzylhydrazine methane 2.00 Phenyl dibenzimidazole tetrasulfonic acid disodium 2.50 0.50 2.00 Uvinul8 T 150 4.00 3.00 4.00 Clinin 4.00 Diethylhexylbutyramine triazinone 1.00 2.00 Phenylbenzimidazole sulfonic acid 0.50 3.00 Methylene bis-benzotriazolyl tetradecyl butyl phenol 2.00 0.50 1.50 Ethyl salicylate Ester 3.00 龄 唆 唆 d d d d d d d d d d 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.00 3.00 Zinc Oxide - Fine 0.25 COMR(V) 0.1 0.5 1.0 0.02 Cyclomethanthene 5.00 5.50 5.00 5.50 Dioxane 矽 1.00 0.60 1.00 0.60 Glycerin 1.00 1.20 1.00 1.20 Sodium Hydroxide Sufficient Sufficient Foot Preservatives 0.30 0.23 0.30 0.23 Essential oil 0.20 0.20 Demineralized water to make up 100 to make up 100 to make up 100 to make up 100 Adjust pH to 6.0 ow sunscreen formulation 1 2 3 4 5 6 7 Glyceryl sulphate SE 0.50 1.00 3.00 1.50 Glycerin Stearate citrate 2.00 1.00 2.00 4.00 I22883.doc -163 - 200816981

Stearic acid 3.00 2.00 PEG-40 stearic acid 0.5 0.50 2.00 cetyl phosphate 1.00 cetearyl sulfate 0.75 octadecyl alcohol 3.00 2.00 0.60 cetyl alcohol 2.50 1.10 1.50 0.60 2.00 COMP. (V) 10.0 0.5 3.0 5.0 0.1 0.02 7.5 Uvinul® APlus, M 2.00 1.50 0.75 1.00 2.10 4.50 5.00 UvaSorb® k2A Ethylhexyl bis-isoamylbenzoxazolylphenyl melamine methoxycinnamic acid ethylhexyl ester Uvinul® MC 80 5.00 6.00 8.00 bis-ethylhexyloxyphenol methoxyphenyl triazine 1.50 2.00 2.50 2.50 butyl methoxy bis-indenyl methane 2.00 2.00 1.50 phenyl dibenzimidazole tetra-n-acid disodium 2.50 0.50 2.00 0.30 ethylhexyl three σ 酮 U U 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 Tetramethyl butyl phenol 2.00 0.50 1.50 2.50 ethyl hexyl salicylate 3.00 5.00 phenol phenol oxazole trioxane 0.50 L00 p-phenylene fluorenyl diterpene Sulfonic acid 1.50 1.00 1.00 0.50 2,6-naphthalene diacetate diethylhexyl ester 3.50 7.00 6.00 9.00 Titanium dioxide - fine 1.00 3.00 3.50 1.50 Zinc oxide · Fine 0.25 2.00 Benzoic acid C12-15 alkyl ester 0.25 4.00 7.00 Two 癸醯Ether 3.50 2.00 Butanediol Dicaprylate / Didecanoate 5.00 6.00 Cocoa Glycerin 6.00 2.00 Dioxane Oxane 0.50 1.00 2.00 Cyclodecyl Oxane 2.00 0,50 0.50 Shea Butter (Shea Oil) 2.00 VP/hexadecene copolymer 0.20 0.50 1.00 Glycerol 3.00 7.50 7.50 5.00 2.50 Sanxianjiao 0.15 0.05 0.30 Carbopol sodium 0.20 0.15 0.25 Vitamin E acetate vinegar 0.60 0.23 0.70 1.00 Bioglue-1 3.00 10.00 Glycine soy (Soybean) Oil 0.50 1.50 1.00 122883.doc -164- 200816981 Ethylhexylglycerol 0.30 DMDM Ethylcarbazide 0.60 0.40 0.20 butylamino decanoic acid carbynyl ester 0.18 0.20 p-Hydroxybenzoic acid decyl ester 0.15 0.25 0.50 benzene Oxyethanol 1.00 0.40 0.40 0.50 0.40 EDTA Trisodium 0.02 0.05 Iminodisuccinic acid tetrasodium 0.25 1.00 1.50 3.00 1.20 5.00 Alcohol 2.00 0.10 0.25 0.30 0.40 0.20 oils demineralized water up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 up to 100 aqueous dispersion of

1 2 3 4 5 Whale stearyl ether-20 1.00 0.50 Recording alcohol 1.00 Carbopol sodium 0.20 0.30 Propylene vinegar / propylene glycol C10-30 vinegar cross-linked polymer 0.50 0.40 0.10 0.50 Sanxianjiao 0.30 0.15 COMP.(V) 5.0 0.5 3.0 0.1 10.0 Uvinul 8 AP1usm 2.00 1.50 0.75 1.00 2.10 UvaSorb® k2A ethylhexyl bis-isoamylbenzoxazolyl phenyl melamine 3.50 methoxy cinnamic acid ethylhexyl ester Uvinul® MC 80 5.00 bis-ethylhexyloxyphenol decyloxy phenyl triazine 1.50 2.00 2,50 Butyl methoxy bis-indenyl methane 2.00 2.00 Phenyl dibenzimidazole tetrasulfonic acid disodium 2.50 0.50 2.00 Ethylhexyl Trioxone Uvinul® T 150 4.00 3.00 4.00 Oaklin 4.00 Diethylhexylbutyramine triazinone 1.00 2.00 1.00 Phenylbenzimidazole sulfonic acid 0.50 3.00 Yttrium bis-benzotriazolyl tetradecyl Butylphenol 2.00 0.50 1.50 2.50 Ethyl hexyl salicylate 3.00 曱 曲 曲 坐 三 三 三 夕 氧 0.5 0.50 p-xylylene methylene dicamphorsulfonic acid 1.50 1.00 1.00 2,6-naphthalenedicarboxylic acid diethyl Ester 7.00 9.00 Titanium Dioxide - Fine 1.00 3.00 3.50 Zinc Oxide - Fine 0.25 C12-15 alkyl benzoate 2.00 2.50 Dimercapto ether 4.00 122883.doc -165 - 200816981

Butanediol Dioctanoate/Didecanoate 4.00 2.00 6.00 Didecyl Carbonate 2.00 6.00 Dimethylpolyoxane 0.50 1.00 Phenyl Trimethylpolysiloxane 2.00 0.50 Shea Butter (Shea Butter) 2.00 5.00 VP/hexadecene copolymer 0.50 0,50 1.00 Triaconyl PVP 0.50 1.00 Ethylhexylglycerol 1.00 0.80 Glycerol 3.00 7.50 7.50 8.50 Glycine Soy C Soy) Oil 1.50 1.00 Vitamin E Acetate 0.50 0.25 1.00 Musk Glycoside 0.60 0.25 Bioglue-1 2.50 0.50 2.00 DMDM carbendazim 0.60 0.45 0.25 Butyl carbamic acid transpropynyl ester 0.20 methylparaben 0.50 0.25 0.15 phenoxyethanol 0.50 0.40 1.00 EDTA Sanner 0.01 0.05 0.10 Ethanol 3.00 2.00 1.50 7.00 Essential oil 0.20 0.05 0.40 Demineralized water to make up 100 to make up 100 to make up 100 to make up 100 to make up 100 wo sunscreen lotion 1 2 3 4 5 cetyl dimethicone 2.50 4.00 polyglyceryl-2 dipolyhydroxy Stearate 5.00 4.50 PEG-30 Dipolyhydroxystearate 5.00 COMP. (V) 5.0 1·0 10.0 0.5 0.1 Uvinul® AP1usim 2.00 1.50 0.75 1 .00 2.10 UvaSorb® k2A Ethylhexyl bis-isoamylbenzopyroxyphenyl melamine 2.00 Ethyl hexyl oxycinnamate Uvinul 8MC 80 5.00 Di-ethylhexyloxyphenol methoxy phenyl triazine 1.50 2.00 2.50 Butyl methoxy bis-decyl decane 2.00 2.00 Disodium phenyl dibenzimidazole tetrasulfonate 2.50 0.50 2.00 Ethylhexatriazolone Uvinul® T 150 4.00 3.00 4.00 Oaklin 4.00 Diethylhexyl Butylamine triazinone 1.00 2.00 1.00 Phenylbenzoic acid 0.50 3.00 Methylene bis-benzotriazolyl tetradecyl butyl benzene 2.00 0.50 1.50 2.50 122883.doc -166- 200816981

Phenol salicylate ethylhexanide 3.00 phenol phenol oxazole trioxane 0.50 p-xylylene methylene dicamphorsulfonic acid 1.50 1.00 1.00 2,6-naphthalene dicarboxylate diethylhexyl ester 7.00 4.00 Titanium dioxide - fine 1.00 3.00 3.50 Zinc Oxide - Fine 0.25 Mineral Oil 12.00 10.00 8.00 Benzoic acid C12-15 alkyl ester 9.00 Dioctyl decyl ether 10.00 7.00 Butanediol dicaprylate / didecanoate 2.00 8.00 4.00 Dioctyl phthalate 5.00 6.00 曱Polyoxane 4.00 1.00 5.00 Cyclodecyl Oxane 2.00 25.00 2.00 Shea Butter (Shea Butter) 3.00 Petrolatum 4.50 VP/hexadecene Copolymer 0.50 0.50 1.00 Ethylhexylglycerol 0.30 1.00 0.50 Glycerol 3.00 7.50 7.50 8.50 Glycine Soy C Soy) Oil 1.00 1.50 1.00 Sulfuric Acid Town MgS〇4 1.00 0.50 0.50 Magnesium Chloride MgCl2 1.00 0.70 Vitamin E Acetate 0.50 0.25 1.00 Ascorbyl Palmitate 0.50 2.00 Bioglue-1 3.50 1.00 DMDM Beneocarbazide 0.60 0.40 0.20 methyl p-hydroxybenzoate 0.50 0.25 0.15 phenoxyethanol 0.50 0.40 1.00 EDTA trisodium 0.12 0 .05 0.30 Ethanol 3.00 1.50 5.00 Essential Oil 0.20 0.40 0.35 Demineralized Water Make up 100 Make up 100 Make up 100 Make up 100 Make up 100 Lipstick 1 2 3 4 Caprylic/Citrate Triglyceride 12.00 10.00 6.00 Octyldodecan 7.00 14.00 8.00 3.00 Butanediol dicaprylate/didecanoate 12.00 Tetraisostearyl tetraisostearate 10.00 6.00 8.00 7.00 Polyglyceryl-3 diisostearate 2.50 Bis-diglyceryl polyglycolyl Ester-2 9.00 8.00 10,00 8.00 Cetyl stearyl 8.00 11.00 9.00 7.00 122883.doc -167 - 200816981

Tetradecyltetradecanoate 3.50 3.00 4,00 3.00 Bee Fill 5.00 5.00 6.00 6.00 Copemicia Cerifera (Camauba) 1.50 2.00 2.00 1.50 White Bee Can 0.50 0.50 0.50 0.40 Stearic Acid C16-40 alkyl ester 1.50 1.50 1.50 COMP. (V) 0.5 3.0 1.0 5.0 Uvinul® APlus, M 2.00 1.50 0.75 9.00 UvaSorb® k2A Ethylhexyl bis-isoamylbenzoxazolylphenyl melamine 2.00 4.00 Oxyloxy Ethyl cinnamate Evinul positive MC 80 3.00 Bis-ethylhexyloxyphenol decyloxy phenyl triazine 1.50 2.00 Butyl methoxy bis-indenyl methane 2.00 Phenyl dibenzimidazole tetrabasic acid 2.50 0.50 2.00 Ethylhexyltriazolone Uvinul® T 150 4.00 3.00 4.00 Oaklin 4.00 Diethylhexylbutyramine triazinone 1.00 2.00 Phenylbenzopyrene. Sitting acid 0.50 3.00 fluorenyl bis-benzotriazolyl tetradecyl butyl phenol 2.00 0.50 1.50 ethyl hexyl salicylate 3.00 cresol triazole oxime 0.50 p-xylylene diterpenoid Sulfonic acid 1.50 1.00 2,6-naphthalene dicarboxylate diethylhexyl ester 7.00 Titanium dioxide - fine 1.00 3.00 Oxidation - fine 0.25 Vitamin E acetate 0.50 1.00 Ascorbyl palmitate 0.05 0.05 Jojoba (Buxux Chinensis) Jojoba) Oil 2.00 1.00 1.00 Essential Oil, BHT 0.10 0.25 0.35 Ricinus Communis (Castor) Oil Make up 100 Make up 100 Make up 100 Make up 100 PIT Lotion 1 2 3 4 5 6 7 8 Single Glyceryl stearate SE 0.50 2.00 3.00 5.00 0.50 4.00 Glyceryl isostearate 3.50 4.00 2.00 Isocetyl ether-20 0.50 2.00 Cetearyl alcohol-12 5.00 1.00 3.50 5.00 Whale stearyl ether-20 5.00 1.00 3.50 122883.doc -168- 200816981

PEG-100 stearate 2.80 2.30 3.30 Cetyl alcohol 5.20 1.20 1.00 1.30 0.50 0.30 Phytate palmate 2.50 1.20 1.50 0.50 1.50 Cetyl dimethoxane copolyol 0.50 1.00 Polyglyceryl-2-di Oleate 0.75 0.30 COMR(V) 0.1 5.0 0.01 0.5 3.0 0.25 10.0 3.0 Uvinul®APWM 2.00 L50 0.75 1.00 2.10 4.50 5.00 2.10 UvaSorb® k2A Ethylhexyl bis-isoamylbenzoxazolylphenyl melamine 4.00 1,50 Ethyl methoxycinnamate Uvinul® MC 80 5.00 6.00 8.00 5.00 Di-ethylhexyloxyphenol methoxyphenyl triazine 1.50 2.00 2.50 2.50 2.50 Butyl methoxy bis-decyl decane 2.00 2.00 1.50 2.00 Phenyldibenzimidazole tetrasulfonic acid disodium 2.50 0.50 2.00 0.30 Ethylhexyl triazinone Uvinul® T 150 4.00 3.00 4.00 2.00 Oaklin 4.00 7.50 Diethylhexyl decylamine triazinone 1.00 2.00 1.00 1.00 1.00 Phenylbenzimidazole sulfonic acid 0.50 3.00 fluorenylene bis-benzotriazolyl tetradecyl butyl phenol 2.00 0.50 1.50 2.50 2.50 ethylhexyl salicylate 3.00 5.00 phenol phenol oxazole trioxane 0.50 1.00 p-xylylene methylene disulfonate 1.50 1.00 1.00 0.50 1.00 2,6-naphthalenedicarboxylate diethylhexyl ester 7.00 10,00 7.50 8.00 Titanium dioxide · fine 1.00 3.00 3.50 1.50 3.50 Zinc Oxide - Fine 0.25 2.00 C12-15 alkyl benzoate 3.50 6.35 0.10 Cocoglyceride 3.00 3.00 1.00 Dimercaptoether 4.50 Dioctyl decyl carbonate 4.30 3.00 7.00 Dibutyl adipate 0.50 0.30 Phenyl trimethacrylate Oxane 2.00 3.50 2.00 cyclomethicone 3.00 C1-5 alkyl galacto-poly 0.50 2.00 122B83.doc -169- 200816981

Sugar hydrogenated cocoa glyceride 3.00 4,00 behenyloxy dioxime polyoxymethane 1.50 2.00 VP/hexadecene copolymer 1.00 1.20 Glycerol 4.00 6.00 5.00 8.00 10.00 Vitamin E acetate 0.20 0.30 0.40 0.30 Shea butter ( Milk oil) 2.00 3.60 2.00 Butylamine decyl citrate 0.12 0.20 Bio-gel-1 0.10 DMDM carbendazim 0.10 0.12 0.13 p-Hydroxybenzoate 0.50 0.30 0.35 Phenoxyethanol 0.50 0.40 1.00 Ethyl Hexylglycerol 0.30 1.00 0.35 Ethanol 2.00 2.00 5.00 EDTA Trisodium 0.40 0.15 0.20 Essential Oil 0.20 0.20 0.24 0.16 0.10 0.10 Demineralized water to make up the foot to make up the foot to make up the foot to make up 100 100 100 100 100 100 100 100 Gel cream 1 2 3 4 Acrylate/C10-30 alkyl acrylate crosslinked polymer 0.40 0.35 0.40 0.35 Carbomer 0.20 0.22 0.20 0.22 Luvigel® EM 1.50 2.50 2.80 3.50 Sanxianjiao 0.10 0.13 0.10 0.13 Cetyl stearyl alcohol 3.00 2.50 3.00 2.50 Benzoic acid C12-15 alkyl ester 4.00 4.50 4.00 4.50 octanoic acid / citric acid triglyceride Oleate 3.00 3.50 3.00 3.50 Titanium Dioxide - Fine 1.00 1.50 Zinc Oxide - Fine 2.00 0.25 COMP. (V) 0.5 10.0 3.0 5.0 Dihydroxyacetone 3.00 5.00 Cyclomethantine 5.00 5.50 5.00 5.50 Dimethylpolyoxane 1.00 0.60 1.00 0.60 Glycerin 1.00 1.20 1.00 1.20 Sodium Hydroxide Sufficient Sufficient Sufficient Preservative 030 0.23 0.30 0.23 Essential Oil 0.20 0.20 Demineralized Water Make up 100 Make up 100 Make up 100 Make up 100 Adjust pH to 6.0 122883.doc -170- 200816981 ow formula self-warming sun-dried product (Self-tanner)

1 2 3 4 5 6 7 Glyceryl succinate SE 0.50 1.00 3.00 1.50 Glyceryl stearate citrate 2.00 1.00 2.00 4.00 Stearic acid 3.00 2.00 PEG-40 stearate 0.50 2.00 Potassium phosphate 1.00 Sulfate sulfate stearyl ester 0.75 octadecyl alcohol 3.00 2.00 0.60 Recorded sterol 2.50 1.10 1.50 0.60 2.00 COMP. (V) 0.1 0.5 0.025 5.0 3.0 10.0 1.0 Dihydroxyacetone 3.00 5.00 4 Titanium dioxide · Fine 1.00 L50 1.50 Zinc oxide - fine 0.25 2.00 benzoic acid C1245 alkyl ester 0.25 4.00 7.00 Dimercapto ether 3.50 2.00 Butanediol dicaprylate / dicaprate 5,00 6.00 Cocoa glyceride 6.00 2.00 Dimethyl oxa oxide 0.50 1.00 2.00 Ring A Polyoxane 2.00 0.50 0.50 Shea butter (dairy oil) 2.00 VP/hexadecene copolymer 0.20 0.50 1.00 Glycerol 3.00 7.50 7.50 5.00 2.50 Sanxianjiao 0.15 0.05 0.30 Carbopol sodium 0.20 0.15 0.25 Vitamin E acetic acid Ester 0.60 0.23 0.70 1.00 Bioglue-1 3.00 10.00 Glycine Soybean (Soybean &gt; Oil 0.50 1.50 1.00 Hexyl glycerol 0.30 DMDM carbendazim 0.60 0.40 0.20 butylamino decanoate 0.18 0.20 methylparaben 0.15 0.25 0.50 phenoxyethanol 1.00 0.40 0.40 0.50 0.40 EDTA trisodium 0.02 0.05 imino group Tetrasodium succinate 0.25 1.00 Ethanol 2.00 1.50 3.00 1.20 5.00 Essential oil 0.10 025 0.30 0.40 0.20 Demineralized water to make up the complement to make up the complement to make up 100 丨100 100 100 100 100 100 122883.doc -171 - 200816981 ow foundation

1 2 3 4 5 6 7 Glyceryl succinate SE 0.50 1.00 3.00 1.50 Glyceryl stearate humate 2.00 1.00 2.00 4.00 Stearic acid 3.00 2.00 PEG-40 stearate 0.50 2.00 Wetyl phosphate 1.00 butyl sulphate sulphate 0.75 octadecyl alcohol 3.00 2.00 0.60 cetyl alcohol 2.50 1.10 1.50 0.60 2.00 COMP. (V) 3.0 5.0 2.0 0.5 1.0 5.0 10.0 Titanium dioxide 10.00 12.00 9.00 8.50 11.00 9.50 10.00 Iron oxide 2.00 4.00 3.00 5.00 3.40 6.00 4.40 Zinc Oxide 4.00 2.00 3,00 C12-15 alkyl benzoate 0.25 4.00 7.00 Dimercaptoether 3.50 2.00 Butanediol dicaprylate / didecanoate 5.00 6.00 Cocoa glyceride 6.00 2.00 Dimethyl oxime Alkane 0.50 1.00 2.00 Cyclomethicone 2.00 0.50 0.50 Shea butter (dairy oil) 2.00 VP/hexadecene copolymer 0.20 0.50 1.00 Glycerol 3.00 7.50 7.50 5.00 2.50 Sanxian gum 0.15 0.05 0.30 Carbomer sodium 0.20 0.15 0.25 Vitamin E Acetate 0.60 0.23 0.70 1.00 Glycine Soybean (Soybean) Oil 0.50 1.50 1.00 Ethylhexyl Glycerol 0.30 DMDM Intraluminal 0.60 0.40 0.20 Butylamine decyl iodide 0.18 0.20 Methylparaben 0.15 0.25 0.50 Phenoxyethanol 1.00 0.40 0.40 0.50 0.40 EDTA Trisodium 0.02 0.05 Iminodiam Acid tetrasodium 0.25 1.00 Ethanol 2.00 1.50 3.00 1.20 5.00 Essential oil 0.10 0.25 0.30 0.40 0.20 Demineralized water to make up the foot to make up the foot to make up the foot 100 100 100 100 100 100 100 122883.doc -172- 200816981 Self-made water-like dispersion

1 2 3 4 5 Cetearyl alcohol-20 1.00 0.50 Resveratrol 1.00 Luvigel Positive EM 2.00 2.50 2.00 Acrylate/Acrylic C10-30 alkylate crosslinked polymer 0.50 0.40 0.10 0,50 Sanxianjiao 0.30 0.15 COMR (V) 3.0 1.0 0.5 0.1 5,0 Dihydroxyacetone 3.00 5.00 Uvinul® APlus, M 2.00 Ϊ.50 0.75 1.00 2.10 Titanium Dioxide · Fine 1.00 1.00 1.00 Zinc Oxide - Fine 1.90 0.25 C12-15 alkyl benzoate 2.00 2.50 Mercaptoether 4.00 Butanediol Dioctanoate / Dicaprate 4.00 2.00 6.00 Didecyl Carbonate 2.00 6.00 Dimethylpolyoxane 0.50 1.00 Phenyl Trimethylpolysiloxane 2.00 0.50 Shea Butter (milk Wood oil) 2.00 5.00 VP/hexadecene copolymer 0.50 0.50 1.00 Tridecyl PVP 0.50 1.00 Ethylhexyl glycerol 1.00 0.80 Glycerol 3.00 7.50 7.50 8.50 Glycine soy (soy) oil 1.50 1.00 Vitamin E acetate 0.50 0.25 1.00 rutin 0.60 0,25 DMDM carbendazim 0.60 0.45 0.25 iodopropynyl butyl carbamate 0.20 decyl hydroxybenzoate 0.50 0.25 0.15 phenoxy 0.50 0.40 1.00 EDTA Trisodium 0.01 0.05 0,10 Ethanol 3.00 2.00 1.50 7.00 Essential Oil 0.20 0.05 0.40 Demineralized water to make up the foot to make up the foot 100 100 100 100 100 After-sun water dispersion 1 2 3 4 5 Cetearyl alcohol ether -20 1.00 0.50 Cetyl Alcohol 1.00 Luvigel® EM 2.00 2.50 2.00 122883.doc -173- 200816981

Acrylate/C10-30 alkyl acrylate crosslinked polymer 0.50 0.30 0.40 0.10 0.50 Sanxianjiao 0.30 0.15 COMR(V) 0.1 5.0 0.5 3.0 1.0 Benzoic acid C12-15 alkyl ester 2.00 2.50 Dimercapto ether 4.00 Alcohol dicaprylate / dicaprate 4.00 2.00 6.00 Didecyl carbonate 2.00 6.00 Dioxane 0.50 1.00 Phenyl trimethyl polyoxyl 2.00 0.50 Triacon PVP 0.50 1.00 Ethylhexyl glycerol 1.00 0.80 Glycerol 3.00 7,50 7.50 8.50 Glycine Soybean (Soybean) Oil L50 1.00 Vitamin E Acetate 0.50 0.25 1.00 Rutin 0.60 0.25 EDTA Trisodium 0.01 0,05 0.10 Ethanol 15.00 10.00 8.00 12.00 9.00 Essential Oil 0.20 0.05 0.40 Mineral water to make up 100 to make up 100 to make up 100 to make up 100 to make up 100 wo lotion 1 2 3 4 5 cetyl dimethoxane 2.50 4.00 polyglyceryl-2 dipolyhydroxystearate 5.00 4.50 PEG-30 dipolyhydroxy Stearate 5.00 COMP. (V) 5.0 10.0 0.1 0.5 1.0 Uvinul® AP1us, m 2.00 1.50 0.75 1.00 2.10 Titanium Dioxide - Fine 1.00 3.00 3.50 Zinc Oxide - Fine 0.90 0.25 Mineral oil 12.00 10.00 8.00 Benzoic acid C12-15 alkyl ester 9.00 Dioctyl decyl ether 10.00 7.00 Butanediol dicaprylate / didecanoate 2.00 8.00 4.00 Dioctyl decyl carbonate 5.00 6.00 Dioxane oxane 4.00 1.00 5.00 Cyclodecyl polyoxyalkylene 2.00 25.00 2.00 Shea butter (dairy oil) 3.00 petrolatum 4.50 VP / hexadecene copolymer 0.50 0.50 1.00 Ethylhexyl glycerol 0.30 1.00 0.50 Glycerol 3.00 7.50 7.50 8.50 122883.doc • 174- 200816981 Glycine Soy C Soy) Oil 1.00 1.50 1.00 Sulfuric Acid Town 1.00 0.50 0.50 Magnesium Chloride 1.00 0.70 Vitamin E Acetate 0.50 0.25 !.00 Ascorbyl Palmitate 0.50 2.00 Bioglue-1 3.50 7.00 DMDM Benecoside 0.60 0.40 0.20 p-hydroxybenzoic acid methyl ester 0.50 0.25 0.15 phenoxyethanol 0.50 0.40 L00 EDTA tri-nano 0.12 0.05 0.30 ethanol 3.00 1.50 5.00 essential oil 0.20 0.40 0.35 demineralized water to make up 100 to make up 100 to make up 100 to make up |100 to make up 100 solid stable emulsion (Picklin Emulsion)

1 2 3 4 5 Mineral oil 16.00 16.00 Octyldodecanol 9.00 9.00 5.00 Octanoic acid/capric acid triglyceride 9.00 9.00 6.00 Benzoic acid C12-15 alkyl ester 5.00 8,00 Butanediol dicaprylate / diterpene Acidate 8.00 Dioctyl decyl ether 9.00 4.00 Dioctyl decyl carbonate 9.00 Hydroxy stearyl hydroxy octadecyl ester 2.00 2.00 2.20 2.50 1.50 Di-stea dimethyl saponin 1.00 0.75 0.50 0.25 Microcrystalline bee sacrifice + paraffin grease 0.35 5.00 Hydroxypropyl methylcellulose 0.10 0.05 Dioxane polyoxane 3.00 COMP. (V) 1.0 0.5 0,1 3.0 5.0 Titanium dioxide + alumina + polydimethyloxane + water 3.00 Titanium dioxide + trimethoxyoctyldecane 2.00 4.00 2.00 4.00 Silica Dimethyl Silylate 2.50 6.00 2.50 Boron Nitride 1,00 Starch / Sodium Metaphosphate · Polymer 2.00, Tapioca Starch 0.50 Sodium Chloride 5.00 7.00 8.50 3.00 4.50 Glycerin 1.00 EDTA Sanna 1.00 1.00 1.00 1.00 1.00 1.00 Vitamin E Acetate 5.00 10.00 3.00 6.00 10.00 Ascorbic acid slag acid 1.00 1.00 1.00 1.00 hydroxybenzene Methyl ester 0.60 0.20 122883.doc -175- 200816981 P-hydroxybenzoic acid propyl ester 0.20 Oxylethanol 0.20 hexamethylene dihydroxyethyl sulfonate 0.40 0.50 0.40 Diazolidine 0.08 Ethanol 0.23 0.20 Essential oil 5.00 3, 00 4.00 Demineralized water 0.20 0.30 — 0.10 Make up to make up the foot to make up 100 100 100 100 100 Lipstick

1 2 3 4 Caprylic/capric triglyceride 12.00 10.00 6.00 Octyldodecan 7.00 14.00 8.00 3.00 Butanediol dicaprylate / dicaprate 12.00 Tetraisotetradecyl stearate 10.00 6.00 8.00 7.00 Polyglyceryl-3 diisostearate 2.50 bis-diglyceride polydecyl adipate-2 9.00 8.00 10.00 8.00 Cetyl stearyl 8.00 11.00 9.00 7.00 Tetradecyl myristate 3.50 3.00 4.00 3.00 Bee fiber 5.00 5.00 6.00 6.00 Tara palm (Brazil) wax 1.50 2.00 2.00 1.50 White beeswax 0.50 0.50 0.50 0.40 C16-40 alkyl stearate 1.50 1.50 1.50 COMR(V) Too L0 3.0 0.1 Uvinul®APlus , M 2.00 1.50 0.75 9.00 Titanium Dioxide · Fine 1.00 3.00 Zinc Oxide - Fine 1.00 0.25 Vitamin E Acetate 0.50 1.00 Ascorbate Palmitic Acid 0.05 0.05 He Ho (Buxux Chinensis) (Yi He (Jojoba)) Oil 2.00 1.00 1.00 ¥ essential oil, BHT 0.10 0.25 0.35 ramie (Ricinus Communis) (castor (Castor)) oil to make up 100 to make up 100 to make up 100 to make up 100 self-service sun-dried PIT lotion 1 2 |3 4 5 6 7 8 glyceryl monostearate SE 0.50 2.00 3*00 5.00 0 .50 4.00 Glyceryl isostearate 3.50 4.00 2.00 Isodecyl ether-20 0,50 2.00 Recording stearyl bond-12 5.00 1.00 3.50 5.00 122883.doc -176- 200816981

Cetearyl alcohol-20 5.00 1.00 3.50 PEG-100 stearate 2.80 2.30 3.30 recorded ptero alcohol 5.20 1.20 1.00 1.30 0.50 0.30 palmitic acid cetyl ester 2.50 1.20 1.50 0.50 1.50 cetyl dimethyl polyoxyalkylene copolymer Alcohol 0.50 1.00 Polyglyceryl-2 0.75 0.30 COMP. (V) 0.1 0.5 0.01 5.0 0.5 3.0 0.025 10.0 Dihydroxyacetone 3.00 5.00 4.00 Uvimil®APhislM 2.00 1.50 0.75 1.00 2.10 4.50 5.00 2.10 Titanium Dioxide - Fine 1.00 1.50 3.50 1.50 1.00 Zinc Oxide - Fine 1.00 0.25 2.00 1.50 Benzoic acid C12-15 oleyl ester 3.50 6.35 0.10 Cocoa glyceride 3.00 3.00 1.00 Dimercaptoether 4.50 Dioctyl phthalate 4 4.30 3.00 7.00 Dibutyl adipate 0.50 0.30 Phenyl triterpene Oxytomane 2.00 3.50 2.00 cyclomethicone 3.00 C1-5 alkyl galactomannose 0.50 2.00 hydrogenated cocoglyceride 3.00 4.00 behenyloxy dioxime polyoxyxane 1.50 2.00 VP/hexadecene copolymer 1.00 1.20 Glycerin 4.00 6.00 5.00 8.00 10.00 Vitamin E Acetate 0.20 0.30 0.40 0.30 Shea butter (dairy oil) 2.00 3.60 2.00 Butyl amide propyl acrylate 0.12 0.20 DMDM carbendazim 0.10 0.12 0.13 methylparaben 0.50 030 0.35 phenoxyethanol 0.50 0.40 1.00 B Hexyl glycerol 0.30 1.00 0.35 Ethanol 2.00 2.00 5.00 EDTA Sanna 0.40 0.15 0.20 Essential oil 0.20 0.20 0.24 0.16 0.10 0.10 Demineralized water supplement 100 Supplement 100 Supplement 100 Supplement 100 Supplement 100 Supplement 100 Supplement 100 Supplement 100 Oil Gel 1 2 3 4 Caprylic/capric triglyceride 12.00 10.00 6.00 Octyldodecan 7.00 14.00 8.00 3.00 Butanediol dicaprylate/didecanoate 12.00 Isopenic acid tetraisostearate 10.00 6.00 8.00 7.00 122883.doc -177 - 200816981 Polyglyceryl-3 diisostearate 2.50 bis-diglyceryl polydecyl adipate-2 9.00 8.00 10.00 8.00 Tetradecyl tetradecanoate 3.50 3.00 4.00 3.00 Tetra-ammonium -18 bentonite 5.00 5.00 6.00 6.00 propylene carbonate 15.00 20.00 18.00 19.50 COMP. (V) 1.0 0.5 3.0 5.0 Vitamin E acetate 0.50 1.00 Ascorbic acid palmitic acid vinegar 0.05 0.05 Joshua (Buxus Chinensis) (Jojoba) oil 2.00 1.00 1,00 essential oil, BHT 0.10 0.25 035 Ridnus Communis (Castor) oil Supplement 100 Supplement 100 Replenishment 100 Replenishment 100 Example 33: In the formulations below, the description includes at least one inorganic pigment, preferably zinc oxide and/or titanium dioxide, and organic UV-A and UV-B filters and according to Example 1. A makeup sunscreen preparation using a combination of COMP. (V). In the examples below, 3,3'-dihydroxyisoxanthene is preferably used as COMP. (V). COMP. (V) is used in the examples below by representing all other described COMP.(V). It will be understood by those skilled in the art that all other specified compounds of COMP. (V) can also be prepared according to Example 1 and used in the formulations specified below. The preparation of the formulations specified below is carried out in a conventional manner known to those skilled in the art. The content of COMP·(V) means 100%. COMP. (V) according to the present invention can be used in the form of a pure form or an oily solution. In the case of an oily solution, the oil content must be adjusted to the amount of COMP. (V) in the particular formulation. &quot;A 7.50 Uvinul MC 80~' : Ethylhexyl cinnamate 2.00 Uvinul Μ 40 'benzophenone-3 0.80 Rylo PG11 'Polyglyceryl dimeric soybean oil fatty acid ester 122883.doc -178 - 200816981 Titanium dioxide, Alumina hydrazine polyoxyalkylene copolymer _ one? Ju Shi Xi 13⁄4 Shea Butter (Shea Butter) C12-15 alkyl benzoate

1.00 Span 60 〇·50 Vitamin E Acetate 3.00 Dracorin 100 SE 1.00 Cetyl Polyoxyethylene Ether CO 410

B 3.00 T-Lite SF

1,00 Cetiol SB 45 6.50 Finsolv TN C 5.00 Butanediol α30 Keltrol&quot; 0.10 EdetaBD &quot;〇.l〇Allantoin~ 66.20 Demineralized Water (Water dem.) D 1.00 Sepigel 305 —1% COMR(V) A sufficient amount of sorbitan stearate acetic acid, glyceryl stearate, PEG-40, hydrazine, diol, celestin, EDTA, disodium, allantoin, demineralized water (Aqua dem.) Preservative 2.00 Uvinul Μ 40 Dibenzophenone-3 0.80 Rylo PG 11 Polyglyceryl Dimeric Large Dan 1.00 Span 60 Dehydrated Sorbitol Fatty Weight 0.50 Vitamin E Acetate. Acetic Acid Fertility — 3.00 Dracorin 100 SE Stearic Acid Glyceride, 1.00 hexadecanol polyoxyethylene ether CO 410 PEG-40 hydrogenated castor oil — B 3.00 Z-COTE MAX emulsified zinc (and) diphenyl sulphide LOO Cetiol SB 45 1 eucalyptus oil (yellow oil) ) — 6.50 Finsolv TN Benzoic acid C12-15 alkane C 5.00 Butanediol Butanediol 0.30 Keltrol Dixian ''~~ 0.10 EdetaBD EDTA Erna' 0.10 Allantoin allanto^^^^__ 66.20 off Mineral water (Aqua dem.) ^ D 2.00 Simulgel NS 1% COMP.(V) &quot; - Λ Π CC \ T ____1 TV xny oc\ hydroxyethyl acrylate / sodium acrylate copolymer, squalane, preservative ~~ —— A /.DU Uvinul MC oU cinnamic acid ethyl hexanoic acid - Ί 2.00 Uvinul A Plus monoethyl Amino group 基 醯 醯 己 己 0.8 0.8 0.80 Rylo PG 11 1 glyceryl - poly large &lt; 2 ^ oil fatty acid 酉 1.00 Span 60 sorbitan stearate 0.50 vitamin E acetate acetate tocopherol 3.00 Dracorin 100 SE glyceryl stearate, PEG-100 stearate 122883.doc -179- 200816981

A 4.00 Uvinul MC 80 Ethylhexyl cinnamate —~- 2.00 Uvinul T 150 Ethylhexyl triazinone - 2.00 Uvinul APlus Ethylaminocarbazide benzyl carbaryl carbamide 0.80 Rylo PG11 Polyglyceryl II Poly Soybean Oil Fatty Acid 1.00 Span 60 sorbitan stearate 0.50 Vitamin E Acetic Acid Hydrazine Tocopherol 3.00 Dracorin 100 SE i glyceride, PE^I^ Recording 醅m 1.00 Cetyl alcohol polyoxygen Vinyl ether CO 410 PEG-40 hydrogenated castor oil B 3,00 Z-COTEMAX 1 zinc (and) diphenyl ϋ ϋ 矽 & 1.00 Cetiol SB 45 Shea butter (dairy oil) 6.50 Finsolv TN i 曱 C12-15 酉 ~ ~ ' — — C 5.00 Butanediol ~ r - m ~ ' ~ ~ a 0.30 Keltrol Sanxianjiao 0.10 Edeta BD EDTA disodium 0.10 allantoin allantoin 66.20 demineralized water (Water dem·) demineralized water (Aqua dem.) D 2,00 Simulgel NS hydroxyethyl acrylate/sodium propylene dimethyl dimethyl sulfonate copolymer, squalane, polysorbate vinegar 6〇1% COMR (Y) Sufficient 1 preservative '' 1.00 hexadecanol polyoxyethylene ether (304 while PEG-40 hydrogenated sesame oil ' B 3.00 Z-COTEMAX zinc oxide (and) a base癸醯基曱聚石夕1.00 Cetiol SB 45 Shea butter (dairy oil) a ^ 6.50 Finsolv TN formic acid C12-15 alkyl ester _ ---- C 5.00 butanediol diol -quot - 0.30 Keltrol Glue --- 0.10 Edeta BD EDTA Disodium - 0.10 Allantoin] Capsules ~ ~~~ 66.20 Demineralized Water (Water dem.) Demineralized Water (Aqua dem.) '- D 2.00 Simulgel NS Hydroxyethyl Acrylate / Propylene decyl dimethyl sodium copolymer, squalane, polysorbate 60 ^ 1% COMP. (V) 1 ----- sufficient preservative _ A 4.00 Uvinul MC 80 ethylhexyl cinnamate ~ 2.00 Uvinul T 150 Ethylhexyl trianthrone 2.00 Uvinul A Plus Di 6-aminoaminohydroxybenzyl hexyl benzoate 0.80 Rylo PG 11 Polyglyceryl dimeric soybean oil fatty acid ester 1.00 Span 60 sorbitan hard Fatty acid ester 0·50 vitamin E acetate acetate tocopherol 3.00 Dracorin 100 SE glyceryl stearate, PEG-100 stearate 1.00 hexadecanol polyoxyethylene ether CO 410 PEG-40 hydrogenated castor oil B 3.00 T -Lite SF Titanium Dioxide, Alumina Hydrate, Dimethyl Oxide 122883.doc -180- 200816981

A 4.00 Uvinul MC 80 Ethylhexyl cinnamate 2.00 UvinulT 150 Ethylhexyl triazinone 2.00 Uvinul A Plus Diethylaminohydroxybenzylidene hexyl benzoate 0.80 Rylo PG11 1 Glycerol poly ugly fatty acid vinegar 1.00 Span 60 sorbitan stearate 0.50 vitamin E acetate acetate tocopherol 3.00 Dracorin 100 SE glyceryl stearate, PEG-100 stearin 1.00 hexadecanol polyoxyethylene ether CO 410 &quot;PEG -40 Hydrogenated Castor Oil ~ B 3.00 Z-COTE MAX Zinc Oxide (and) Diphenyldecyl Methane Polydecane 1.00 Cetiol SB 45 Shea Butter (Shea Butter) 6.50 Finsolv TN Benzoic Acid C12- 15 alkyl ester C 5,00 butanediol butanediol 0.30 Keltrol Dioxin 0.10 EdetaBD EDTA Erina 0,10 allantoin allantoin 66.20 demineralized water (Water dem.) demineralized water (Aqua dem.) D 2.00 Simulgel NS hydroxyethyl acrylate / propylene dimethyl geranyl sulphate copolymer, squalane, polysorbate 6 〇 1% COMP. (V) sufficient preservative burning / 曱 polyoxane Copolymer LOO Cetiol SB 45 Shea Butter (Shea Butter) 6.50 Finsolv TN Benzoic acid C12-15 alkyl ester C 5. 00 Butanediol Butanediol 0.30 Keltrol Sanxianjiao 0.10 EdetaBD EDTA Disodium 0.10 Allantoin Allantoin 66.20 Demineralized Water (Water dem.) Demineralized Water D 2.00 SimulgelN Propionate Ethyl Ester/Acetone Sodium dimethyl bovine sodium sulphate copolymer, squalane, polysorbate 60 1% COMP. (V) sufficient preservative A 4.00 Uvinul MC 80 acid ethyl vinegar ~~~ —--i LOO UvinulT 150 Ethylhexyldiazinone- 2.00 Parsol 1789 0.80 Rylo r (jr 11 polyglyceryl-poly ugly fatty acid ester one - 1.00 Span 60 sorbitan stearic acid cool one 0.50 vitamin E acetic acid cool _ 1 3.00 Dracorin 100 SE 1.00 hexadecanol oxyethylene ether CO 410 ^ B 3.00 T-Lite SF-S ~Tocopherol tocopherol~~ ——. Acid glyceride, P@-100 Hui compensation----- Dioxide f stone Xiyun water ^ oxidized dimethyl polyoxane total ' 122883.doc -181 - 200816981

A 4.00 Uvinul MC 80 ethylhexyl cinnamate 1.00 UvinulT 150 ethylhexyl triazinone 2.00 Parsol 1789 butyl decyl dibenzyl decyl decane 0.80 Rylo PG11 polyglyceryl dimeric soybean oil fatty acid ester 1.00 Span 60 Sorbitan sorbitate 0.50 vitamin E acetate acetate probiotics &quot;&quot; 3.00 Dracorin 100 SE Stearic acid glycerin vinegar, PEG-100 stearic acid vinegar 1.00 hexadecanol polyoxyethylene ether CO 410 PEG- 40 Hydrogenated castor oil B 3.00 Z-COTE MAX Zinc oxide (and) Diphenyl fluorenyl fluorene oxalate 1.00 Cetiol SB 45 Shea butter (dairy oil) 6.50 Finsolv TN Benzoic acid C12-15 alkyl ester C 5.00 Butanediol Butanediol 0.30 Keltroi Sanxianjiao 0.10 EdetaBD EDTA Disodium 0.10 Allantoin Urticin 67.10 Demineralized Water (Water dem.) Demineralized Water (Aqua dem.) D 2.00 Simulgel NS Hydroxyethyl Acrylate / Copolymer of propylene decyl dimethyl tauronate, squalane, polysorbate 6 〇 0.1% COMP. (V) Sufficient preservative LOO Cetiol SB 45 Shea butter (dairy oil) 6.50 Finsolv TN benzoic acid C1245 alkane for &quot;&quot; ^ C 5.00 butanediol Alcohol 0.30 Keltroi Sanxianjiao 0.10 EdetaBD EDTA disodium 0.10 allantoin urinary sputum 66.70 demineralized water (Water dem.) demineralized water (Aqua dem.) D 2.00 SimulgelNS hydroxyethyl acrylate / propylene fluorenyl dimercapine Sodium asperate copolymer, squalene, polysorbate gg60 0.5% COMP. (V) sufficient amount of humic agent &quot;&quot; A 5.00 Uvinul N 539 T Clining &quot; 2.00 Parsol 1789 butyl decyloxy Two decyl decane 0.80 Rylo PG11 Polyglyceryl dimeric soybean oil fatty acid ester 1.00 Span 60 sorbitan stearate 0.50 vitamin E acetate '&quot; acetic acid tortoise' 3.00 Dracorin 100 SE stearic acid Glyceryl ester, PEG-100 stearic acid eyesight — LOO cetyl alcohol polyoxyethylene ether CO 410 &quot; PEG-40 hydrogenated castor oil - B 3.00 T-Lite SF-S Oxidation, gravel hydrate, oxidation ^, 曱 矽 矽 烧 / dioxane polyoxyalkylene copolymer 1.00 Cetiol SB 45 Shea butter (dairy oil) 6.50 Finsolv TN benzoic acid C12-15 alkyl ester ^ 122883.doc • 182- 200816981

A 5.00 UvinulN 539 T Oaklin 2.00 Uvinul A Plus Diethylamino vial base hexyl benzoic acid 0.80 Rylo PG11 Polyglyceryl dimerized macrodans fatty acid vinegar 1.00 Span 60 sorbitan stearic acid Ester 0.50 Vitamin E Acetate Acetate Tocopherol 3.00 Dracorin 100 SE Glyceryl Glycolate, PEG-100 Glycol "Cool 1.00 Cetyl Polyoxyethylene Ether CO 410 PEG-40 Hydrogenated Castor Oil" - B 3.00 T -Lite SF Titanium Dioxide, Alumina Hydrate, Dimethicone, Sodium Burning / Polyoxyalkylene Copolymer LOO Cetiol SB 45 Shea Butter (Shea Butter) 6.50 Finsolv TN Benzoic Acid C1245 -- C 5.00 Butanediol Butanediol 0.30 Keltrol Sanxianjiao 0.10 Edeta BD EDTA Erina ~ &quot; -- 0.10 Allantoin Allantoin 65.20 Demineralized Water (Water dem.) Demineralized Water (Aqua dem.) D 2,00 Simulgel NS hydroxyethyl acrylate/acryloyl fluorenyl phthalate copolymer, horn complex, polysorbate cool 60 2% COMR(V) sufficient preservative C 5.00 butanediol butyl Alcohol 0.30 Keltrol Sanxianjia~~~ O.lOEdeta BD EDTA Disodium-'--- 0.10 allantoin Allantoin ~-- 66.20 demineralized water (Water dem.) demineralized water (Aqua dem.) D 2.00 Simulgel NS hydroxyethyl acrylate / sodium propylene dimethyl dimethyl sulfonate copolymer, squalor burning, poly Sorbitol ester 6〇1% COMP.(Y) A sufficient amount of preservative A 5.00 Uvinul N 539 T Aoke Lie ' ~ ^ 2.00 Uvinul A Plus monoethylamino hydroxy decyl hexyl stupid ^ 0.80 Rylo PG 11 Glyceryl dimerized ugly oil fatty acid ester - 1.00 Span 60 sorbitan stearate ^- 0.50 vitamin E acetate acetate tocopherol ~~ 3.00 Dracorin 100 SE glyceryl stearate, PEG-100 stearin ^- 1·00 hexadecanol polyoxyethylene ether CO 410 PEG-40 hydrogenated castor oil '^^—- B 3.00 Z-COTE MAX zinc oxide (and) diphenyl fluorenyl fluorene 1.00 Cetiol SB 45 milk Hibiscus oil (dairy oil) 6.50 Finsolv TN benzoic acid C12-15 alkane vinegar ^ C 5.00 butanediol - butanediol 0.30 Keltrol Sanxian gum ~ O.lOEdeta BD EDTA disodium ~^- 122883.doc -183 · 200816981

0.10 allantoin

66.70 demineralized water (Water dem.) 2.00 Simulgel NS allantoin hydroxyethyl acrylate / propylene fluorenyl fluorenyl sulfonate copolymer, horn shark, polysorbate 60

Preservative A 5.00 Uvinul N 539 T 2.00 Uvinul A Plus Ethylaminobenzylbenzyl benzoyl benzoate 0.80 Rylo PG 11 Glyceryl dimerized ugly fatty acid ester 1.00 Span 60 _ sorbitan stearic acid Ester 0,50 Vitamin E Acetate Tocopherol Tobacco 3.00 Dracorin 100 SE Stearic acid glyceride, PEG-100 stearate 1·00 hexadecanol polyoxyethylene ether CO 410 屮4〇 hydrogenated castor oil B 3.00 Z-COTE MAX _Zinc oxide (and) Diphenyl fluorene polyoxane LOO Cetiol SB 45 Shea butter (dairy oil) 6.50 Finsolv TN benzoic acid C12-15 alkyl ester C 5,00 Butanediol butanediol 0.30 Keltrol Sanxianjiao O.lOEdetaBD 1 EDTA disodium o.io urinary hormone i Allantoin 2.0Mexoryl SX p-Benzylmethylene dicamphorsulfonic acid-66.20 demineralized water (Water dem. Demineralized water (Aqua dem.) D 2.00 Simulgel NS Hydroxyethyl acrylate/acryloyl fluorenyl sulfonate copolymer, squalane, polysorbate 60 1% COMP. (V) Sufficient preservative A 5.00 Uvinul N 539 T Oaklin 2.00 Uvinul A Plus Diethylaminohydroxy-hydroxydecyl hexyl benzoate 0.80 Rylo PG 11 Polyglyceryl dimeric soybean oil fatty acid ester „ 1,00 Span 60 sorbitan stearate 0.50 vitamin E acetate acetate tocopherol 3.00 Dracorin 100 SE glyceryl stearate, PEG-100 stearic acid Ester 1.00 hexadecanol polyoxyethylene ether CO 410 PEG-40 hydrogenated castor oil B 3.00 Z-COTE MAX zinc oxide (and) diphenyl fluorenyl polyoxyalkylene 1.00 Cetiol SB 45 Shea butter (milk Oil) 6.50 Finsolv TN benzoic acid C12-15 alkyl ester C 5.00 butanediol butanediol _ 0.30 Keltrol Sanxian gum O.lOEdetaBD EDTA disodium - 0.10 urinary urinary urinary vesicle 2.0Mexoryl SX p-xylylene Dicamphorsulfonic acid 65.20 demineralized water (Water dem·) demineralized water (Aqua dem.) 122883.doc •184· 200816981

D 2.00SimulgelNS 2% COMP.(V) Hydroxyethyl acrylate thiol dihenic acid yoghurt, horn simmer, polysorbate vinegar preservative

A 5.00 Uvimil N 539 T 2.00 Uvinul A Plus

2.00 Mexoryl XL Oakley

Phenolic azole trioxane

PEG-40 hydrogenated castor oil

Shea Butter (Shea Butter) Stupid C12-15 alkane 6.50 Finsolv TN

0.10 Edeta BD $10 allantoin EDTA disodium allantoin 0,80 Rylo PG11 LOO Span 60

0.50 Vitamin E Acetate 3.00 Dracorin 100 SE 1·00 Cetyl Polyoxyethylene Ether CO 410

B 3.00 Z-COTEMAX Polyglyceryl dimerized soybean oil fatty acid ester sorbitan stearic acid hydrazine acetic acid glycerol stearate, PE ^-100 hard zinc oxide (and) diphenyl methacrylate Shi Xi oxygen

67·10 Demineralized Water (Water dem·) 2.00 SimulgelNS 0.1% COMR(V) Sufficient demineralized water (Aqua dem.) Hydroxyethyl acrylate/acryloyl acrylate Sodium squalane copolymer Kikuhuang Huang Polysorbate 60 Preservative A 5.00 Uvinul N 539 T Oaklin ~^ 2.00 Tinosorb S Bis-ethylhexyloxyphenol methoxyphenyl 0,80 Rylo PG 11 Polyglyceryl dimerization Soybean oil fatty acid ester 1.00 Span 60 sorbitan stearate 0.50 vitamin E acetate _ acetic acid fertility 酴-'''- 3.00 Dracorin 100 SE glyceryl stearate, PEG-100 stearic acid culvert 1.00 Hexaol polyoxyethylene ether CO 410 &quot;^G-40 hydrogenated castor oil ^- B 3.00 Z-COTEMAX zinc (and) diphenyl fluorenyl fluorene ~ 1.00 Cetiol SB 45 Shea butter (milk Oil) 6.50 Finsolv TN benzoic acid C12-15 alkyl ester-C 5.00 butanediol butanediol &quot;~~ 0.30 Keltrol Dioxin 0.10 Edeta BD EDTA Erina-0.10 allantoin allantoin ~ 66.20 demineralized water (Water dem.) Demineralized water (Aqua dem.) D 2.00 Simulgel NS hydroxyethyl acrylate/acrylic methacrylate sodium copolymer, squalor, poly mountain Ester 60 1% COMP · (V)

122883.doc -185- 200816981

A sufficient amount of preservative A 7.50UvinulMC80 Ethyl cinnamate ethylhexyl 5.00 UvinulN 539 T Octolide 3.00 Emulgade PL 68/50 Recording ant stearyl glycoside, cetostearyl alcohol 2.00 Dracorin 100 SE Stearic acid Glyceride, PEG-100 stearate 1.00 Fitoderm Sharks 〇 · 50 hexadecanol polyoxyethylene ether WO 7 PEG-7 hydrogenated castor oil · 50 hexadecanol polyoxyethylene ether PS 20 Polysorbate 20 2.00 Dry Flo Pure Starch Octenyl Succinic Acid B 5.00 Z-COTE MAX Zinc Oxide (and) Diphenyldecyl Methane C 4 00 1,2-Propanediol Care Propylene Glycol 0.20 Keltrol· Sanxian Gum 0.50 Simulgel 600 acrylamide/propylene decyl fluorenyl taurate copolymer, isohexadecane, polysorbate 8 〇 100 demineralized water (Water dem·) demineralized water (Aqua dem.) Preservative 0.50 Vitamin E Acetate Tocopherol 2% COMR(V) 1.00 RetiSTAR Caprylic/capric triglyceride, sodium ascorbate, fertility, retinol A 7.50 Uvinul MC 80 Ethyl cinnamate Hexyl ester 2.00 UvinulN 539 T Oaklin 3.00 Emulgade PL 68/50 Whale Sacrifice Glycoside, cetostearyl alcohol 2.00 Dracorin 100 SE glyceride, PEG-100 stearate 1.00 Fitoderm squalane 0.50 hexadecanol polyoxyethylene ether WO 7 PEG-7 hydrogenated naring oil 0·50 sixteen Alcohol polyoxyethylene ether PS 20 Pear ester 20 2.00 Dry Flo Pure Aloctenyl succinate B 5.00 T-Lite SF-S Titanium dioxide, Shi Xishi hydrate, alumina hydrated dimethyl polyoxan / dimerization Alkane copolymer C 4.00 1,2-propanediol care propylene glycol 0.20 Keltrol Dioxin 0.50 Simulgel 600 ' ^ olefinic amine / propylene decyl dimercapto taurate sodium hexaiso compound, polysorbate 80 complement 100 demineralized water (Water dem·) water (Aqua dem. wattage preservative 〇·5〇 vitamin E acetate 1% COMP. (V) tocopherol 2.00 RetiSTAR Xin warm / citric acid triglyceride, ascorbic acid Nano, and retinol 122883.doc -186- 200816981

A 7.50 UvinulMC80 Methoxycinnamic acid ethyl vinegar 5,00 UvinulN 539 T Oaklin 3.00 Emulgade PL 68/50 Whale stearyl citrate, cetostearyl alcohol 2.00 Dracorin 100 SE Stearic acid glyceride PEG-100 stearate 1.00 Fitoderm squalane 0.50 hexadecanol polyoxyethylene ether WO 7 PEG-7 hydrogenated castor oil 〇, 5 〇 hexadecanol polyoxyethylene ether PS 20 polysorbate 20 2.00 Dry Flo Pure Starch Binding Group No. Acid Chain B 5.〇〇T-LiteSF Titanium Dioxide, Alumina Hydrate, Dimethicone/Methyl Hexane Copolymer C 4.00 1,2-Propanediol Care Propylene Glycol 1.00D- Panthenol 50P Pantosan, Propylene Glycol 0.20 Keltrol Sanxian Gum 0.50 Simulgel 600 Acrylamide / propylene decyl dimethyl taurate copolymer, isohexadecane, polysorbate 80 to make up 100 demineralized water ( Water dem.) Aqua dem. Preservatives ______________- 〇·50 Vitamin E Acetate Tocopherol 1% COMP.(V) 1.00 RetiSTAR octanoic acid/capric acid triglyceride, sodium ascorbate Tocopherol, retinol

Α 5·50 Uvinul MC 80 Ethylhexyl methoxycinnamate 2.00 Uvinul A Plus Diethylaminohydroxyl decyl hexyl benzoate 3.00 UvinulN 539 T Oak climatic: --^ 3.00 Emulgade PL 68 /50 瑕 瑕 瑕 、 、 、, cetostearyl stearyl alcohol 2.00 Dracorin 100 SE glyceryl stearate, PEG-100 stearate 1.00 Fitoderm horn farm 0.50 hexadecanol polyoxyethylene ether WO 7 Ρϋϋ- 7 hydrogenated castor oil 0.50 hexadecanol polyoxyethylene ether PS 20 sorbitol ester 20 2.00 Dry Flo Pure starch octenyl succinate aluminum B 5.00T-LiteSF titanium oxide, oxidized Ming hydrate, dimethyl sulphur _Oxygen, tiger/polymethicone 綮铷C 4,00 1,2-propanediol care propylene glycol 0.20 Keltrol Dioxin 0.50 Simulgel 600 acrylamide/acryloyl fluorenyl bismuthyl citrate 80 to make up 100 demineralized water (Water dem·) demineralization -- sufficient preservative --- 〇 50 vitamin E acetate tocopherol 2% COMP. (V) ------ 1.00 RetiSTAR Citric acid triglyceride blood acid ^, 1 hydroxyphenol, retinol 122883.doc -187· 200816981

A LOO Abil Care 85 bis-PEG/PPG-16/16 PEG/PPG-16/T^Z^ polyoxy siloxane, caprylic/capric acid triglyceride 3.00 hexadecanol polyoxyethylene ether CO 40 PEG-40 Hydrogenated castor oil &quot;~ 〇·30 hexadecanol polyoxyethylene ether WO 7 PEG-7 hydrogenated castor oil ~ 2.00 Parsol 1789 butyl methoxydibenzyl hydrazin methane ~ ' 2.00 Mexoryl XL cresol triazole oxime 10.00 Witconol APM PPG-3 tetradecyl ether ~ 1.00 UvinulT 150 Ethylhexyl triterpene ~ ~' 1.00 Dow Coming 345 Fluid Cyclopentaoxane, cyclohexyloxane 5.00 UvinuiN 539 T Oakley ~~ --- B 3.00 Z-COTEMAX Zinc Oxide (and) Diphenylsulfonylphosphonium sulphate 'C 5·00 1,2' Propylene Glycol Propanol 1.00 Mexoryl SX P-Promethylene Dicamphor Sulfate 0.20 Keltrol Sanxianjiao -- 0.06 Edeta BD EDTA Monosodium - 0.04 TEA _ Diethanolamine: ~— 0.30 Carbopol Ultrez 10 P Carbomer 'one' 63.50 demineralized water (Water dem.) Demineralized water (Aqua dem.) One ^ 1% COMP · (V) D full-bodied essential oil 0.50 flow aid DMDM ethyl carbamide

A 5?50 Uvinul MC 80 Ethylhexyl methoxycinnamate' 2.00 Uvinul A Plus monoethylaminocarbazide benzylidene benzoic acid West ^ 3.00 UvinuiN 539 T Oakley ' 3.00 Emulgade PL 68/ 50 Loose stearyl sugar, cetyl stearyl alcohol 2.00 Dracorin 100 SE glyceryl stearate, PEG-100 stearin ^ 1.00 Fitoderm squalane ~ 0.50 hexadecanol polyoxyethylene ether WO 7 PEG-7 Hydrogenated castor oil - 0,50 hexadecanol polyoxyethylene ether PS 20 Polysorbate 20 2.00 Dry Flo Pure Starch octenyl succinate - B 5.00T-LiteSF-S Titanium oxide, vermiculite hydrate, oxidation Aluminum water, methacrylate, dimethyl oxane, φ铷C 4.00 1,2-propanediol, care, propanol, 0.20, Keltrol, dioxan, 2.00, Simulgel, NS, hydroxyethyl acrylate, propylene Sodium sulfonium taurate copolymer, squalene, polysorbate 60 66.30 demineralized water (Water dem.) demineralized water (Aqua dem.) sufficient preservative 0.50 vitamin E acetate acetate tocopherol 0.5% COMP.m 1.00 RetiSTAR octanoic acid/capric acid triglyceride, sodium ascorbate, tocopherol, retinol 122883.doc -188 - 200816981 A 2.00 Cetyl polyoxyethylene ether A6 WWW stearyl ether-6, octadecyl alcohol 2.00 Cetyl polyoxyethylene ether A 25 Cetearyl alcohol · 25 3.00 Syncrowax HRC Glycerol diammonium Ester 2.00 Lanette 0 Cetyl stearyl alcohol 2.00 Luvitol EHO + Ethylhexanoic acid Whale hard -- 5.00 Uvinul MC 80 Methoxycinnamate ethylhexyl ester L00Ganex V-220 VP / decene olefins - 7.00 Isopropyl palmitate isopropyl palmitate B 3.00 Z-COTE MAX Zinc oxide (and) diphenyl fluorene-based polymethicone C 0.20 Keltrol Dioxin 0.50 Simulgel NS hydroxyethyl acrylate / propylene thiol Dimethyl A cattle, sour copolymer, squalane, polysorbate 65.10 Demineralized water (Aqua dem.) - 0.20 Edeta BD H3TA Erna ~ ~~~-- 5.00 1 , 2-propanediol care propylene glycol _ ---- 0.5% COMR (V) _ acetic acid fertility ~---- D LOO vitamin E acetate sufficient preservative-----^. ---^JA 2 ·00 hexadecanol polyoxyethylene ether A6 cetearyl alcohol-6, eighteen ^-- i wax stearyl ether-25 ~~^------ 2.00 cetyl polyoxyethylene ether A 25 3.00 Syncrowax HRC Triglyceride Mountain acid ester ^_ 2.00 Lanette 十六 hexadecanol octadecyl alcohol ~^ 2.00 Luvitol EHO ethylhexanoic acid cetyl stearyl acetoxy acid 6 base &amp; vinegar ~^^^^_ 5^00 Uvinul MC 80 _&quot;&quot;&quot;&quot;&quot; 1.00 GanexV-220 VP/Eicosene Copolymer 7.00 Isopropyl palmitate isopropyl palmitate^ B 3.00 T-Lite SF Titanium dioxide, alumina water valley oxygen burning /曱Polyoxyalkane Copolymer ~Metformin C 0.50 Keltrol Sanxian Gum 0.50 Simulgel NS Hydroxyethyl acrylate / Sodium Acrylate Copolymer, Squalane, Polysalkonium Sulfate 65.10 Demineralized Water (Water dem.) Mineral water (Aqua dem.) 0.20 Edeta BD EDTA disodium - ' 5.00 1,2-propanediol care propylene glycol - 0.5% COMP. (V) 1 ---------- &quot;------ - __ D 1,00 Vitamin E Acetate B Hopeful Preservatives ------- _ _ 00 2.00 Cetyl Polyoxyethylene Ether 8 6 Cetearyl Ether Ether-6, 182.00 Cetyl polyoxyethylene ether into 25 cetyl stearyl ether-25 ^ 3.00 Syncrowax HRC glycerin Sanshan sign acid brewing a ' 2.00 Lanette 十六 hexadecanol octanol ~ 2.00 Luvitol EHO ethyl hexanoic acid recorded stearyl Vinegar ~ 122883 .doc -189- 200816981 5.00 Uvinul MC 80 methoxy cinnamic acid ethyl hexanoic acid LOO Ganex V-220 VP / eicosene copolymer - 7.00 isopropyl palmitate isopropyl palmitate B 3.00T-LiteSF-S Titanium Dioxide, Vermiculite Hydrate, Alumina Hydrate, Ethylene Oxide/Dimethyl Hexane Copolymer 0.5C 0.50 Keltrol Sanxian Gel 0.50 Simulgel NS Hydroxyethyl Acrylate/Propylene Methyl Dimethyl Acetate Copolymer, squalane, polysorbate 60' 64.60 demineralized water (Water dem.) Demineralized water (Aqua dem.) 0.20 Edeta BD EDTA Erina 5.00 1,2-propanediol care propylene glycol --- 1% COMP (V) D 1·00 vitamin E acetate tocopheryl acetate sufficient preservative

A 2.00 Cetyl polyoxyethylene ether A6 cetearyl alcohol ~-- 2.00 cetyl polyoxyethylene ether A 25 cetearyl alcohol-25^ ~ - 3.00 Syncrowax HRC glycerol 2.00 Lanette 十六 Cetyl stearyl alcohol ---- 2.00 Luvitol EHO ethyl hexanoate whale 壌 hard fat ' ----- 5.00 Uvinul MC 80 methoxy cinnamic acid B; -- 1.00 Ganex V-220 VP / Eicosene copolymer system ---- 7.00 isopropyl palmitate isopropyl hydrazine bismuth —~————— B 3.00 T-Litc SF-S Titanium dioxide, bismuth, _polyoxy decane C 0.50 Keltrol Sanxian; ~Copolymer 0:50 Simulgel NS hydroxy hydroxy &quot; sodium sulphate transester, 64.10 demineralized water (Water dem.) demineralized water (Aqua ^^60__ 2.00 Neoheliopan AP phenyl diphenyl wood saliva -— 0.20 Edeta BD EDTA Disodium ———^--___ 5.00 1,2-Propanediol Care Propylene Glycol~—One—---—— D 1,00 Vitamin E Acetate Tocopherol acetate ^^_ 1% COMP. (V) Sufficient preservative ~_ A 2.00 Cetyl polyoxyethylene ether A6 Record wax stearyl ether-6 ------ 2.00 Cetyl polyoxyethylene ether A 25 Recorded hard fat --- —-- 3.00 Syncrowax HRC Glycerin山#酸酷=—-----__ 2.00 Lanette 十六 Cetyl alcohol ten _ '——---- 2.00 Luvitol EHO 7.00 Uvinul N 539 T ^___ 1.00 Ganex V-220 VP / twenty carbon ~- -- 7.00 isopropyl palmitate palmitate isophthalate ^——--

122883.doc -190- 200816981

Α _ 2.00 hexadecanol polyoxyethylene ether Α 6 cetyl stearyl ether ---- 2.00 hexadecanol polyoxyethylene ether A 25 cetearyl alcohol a 3.00 Syncrowax HRC glyceryl tribehenic acid 8|~ --- ^ 1.00 Lanette 十六 hexadecanol octadecyl alcohol ~~ '~ 2.00 Luvitol EHO ethylhexanoic acid cetyl hard sulphonic one ' 2.00 Mexoryl XL phenolic phenol oxazole trioxane ^ one-one ^ 5.00 UvinulN 539 T Okley林'~-----1·00 Ganex V-220 VP/Eicocarbene total ^---7.00 isopropyl palmitate isopropyl palmitate '--^ B 3.00 T-Lite SF Titanium Oxide, Alumina Hydrate, Dimethyl Polyoxyl Membranes/Methyl Polyoxyalkylene Copolymer AC 0.50 Keltrol Sanxian Glue '0.50 Simulgel NS Propane Field Acid _/Bing 醯 曱 曱 牛Sodium sulphate, squalane, polysorbate 60 65.10 demineralized water (Water dem.) demineralized water (Aqua dem.) 0.20 Edeta BD EDTA disodium 5.00 1,2-propanediol care propanol &quot; --^ D 1.00 Vitamin E Acetate Tocopherol 0.5% COMP. (V) Sufficient Prevention; ^B 3,00 T-Lite SF-S Concentrate C O.SOKeltrol Sanxian Gum ^^ 0.50 SimulgelNS Acrylic acid Co-polymer ιΛΜ: poly"Ϊ60, 64,60 demineralized water (Water dem.) demineralized water (AqG^I-1.00 Mexoryl SX p-phenylene methylene---a 0.20 Edeta BD EDTA disodium-~ —————————^ 5.00 1,2-propanediol care propylene glycol '^S-—one ^ D 1·〇〇 vitamin E acetate acetate fertility ——————^ 1% COMP.(V) '·~~ -----------—·&quot;&quot;* Sufficient preservatives~ _______—&quot;&quot;&quot; ^ ------------ 1.00 Urea ϋ -- -- - 2.00 Neoheliopan AP Phenyl dibenzimidazole tetrahydro acid dihydrazide 2.00 Glycerin 87% Glycerin &quot; --- 1.20 Aristoflex AV C Acrylic acid dimethyl oxetine ammonium / hydrazine copolymer 71.30 Demineralized water ( Water dem.) Demineralized water (Aqua dem.) Β 3·00 hexadecanol polyoxyethylene ether CO 40 PEG-40 hydrogenated castor oil sufficient essential oil 5.00 Miglyol812 octanoic acid / citric acid triglyceride 2.00 UvinulN 539T Oak _ 8.00 Z-COTE MAX zinc oxide (and) diphenyl fluorenyl polyoxyalkylene 122883.doc -191 - 200816981

5% COMP.(V) Sufficient Preservative 5.00 Z-COTE MAX Zinc Oxide (and) Diphenyldecyl Methyl Polyoxane 2.00 Parsol 1789 Butyl Oxime Dibenzyl decyl 1.00 Uvimii TlSO Ethyl Hexyltriazinone 5.00 Uvinul MC 80 Ethylhexyl methoxycinnamate 2.00 UvimilT 539 N Oaklin 0.50 AM 350 Dioxane 2.75 Camico wax LT 20 Brazil Palm (Brazil 堰Copemica Cerifera Wax, Paraffin 3.70 Candid Latitude LT 281 LJ Candelilla (Euphorbia Cerifera) 躐 1.80 Beeswax 3050 PH Bee Sting 3.20 TeCero Wax 30445 Microcrystalline Wax 3.20 TeCero Wax 1030K Microcrystalline wax 1.34 Cutina CP Cetyl palmitate 6.40 Vaseline petrol 7.30 Softisan 100 Hydrogenated cocoa glyceride 10.00 Luvitol EHO Ethylhexanoate whale stearyl ester 0.17 natural bisabolol myrrh alcohol 1.84 Vitamin E acetate Tocopherol acetate 0.42 D, La-fertility tocopherol 1% COMP. (V) 40.38 Castor oil (Castor) (Ricinus Communis) oil 5.00 T-Lite SF titanium dioxide, oxidized hydrate, dimethyl聚石夕氧烧/曱聚矽氧烷Polymer 2.00 Parsol 1789 Butyloxydibenzylhydrazine methane 1.00 Uvinul T150 Ethylhexyl tridecyl ketone 3.00 Uvinul MC 80 T-Ethyl cinnamate ethyl hexyl ester 2.00 Uvinul N 539 T Oaklin 0.50 Abil 350石夕氧院 2.75 尼尼蠛 LT 20 ^西棕 Mg西蜡椋叶) wax, paraffin 3.70 堪地拉拉 LT 281 LJ Candelilla (Euphorbia Cerifera) can be 1.80 beeswax 3050 PH 3·20 TeCero wax 30445 microcrystalline feed 3·20 TeCero wax 1030 K microcrystalline woven 1.34 Cutina CP palmitic acid whale wax 6.40 petroleum jelly broken 7.30 Softisan 100 hydrogenated cocoa glyceride 10.00 Luvitol EHO wax stearyl ester 0.17 natural Medicinal alcohol, medicinal alcohol 122883.doc -192- 200816981

1.84 Vitamin E acetate tocopherol acetate '0.42 D, La-tocopherol tocopherol 1% COMP. (V) 40.38 million sesame oil (Castor) (Kicimis Connminis) oil 5.00T-Lite SF-S Titanium Dioxide, Shishi Stone Hydrate, Oxidized Hydrate, Poly(A) Oxide/Dimethyl Hexane Copolymer 2.00 Uvinul A Plus - Alkyl® Hydroxyl Benzoyl Hexyl Benzoate 2.00 Mexoryl XL cresol tromethoxazole trioxane 3.00 Uvinul MC 80 methoxy cinnamic acid ethylhexyl acrylate 0.50 Abil 350 Dimethophthalol 2.75 Carnival wax LT 20 Brazilian brown 橺 (Brazil 蠛 brown leaf) 壌, stone躐 3.70 Candidella wax LT 281 LJ Candelilla (Euphorbia Cerifera) 1.80 Beeswax 3050 PH Beeswax _ 3.20 TeCero wax 30445 Microcrystalline soil 3.20TeCero wax 1030K microcrystalline wax _ 1.34 Cutina CP Palm Cetyl ester 6.40 Vaseline petrol 7.30 Softisan 100 Hydrogenated cocoa glyceride 10.00 Luvitol EHO Ethyl caproate cetyl stearyl ester 0.17 Natural bisabolol Bisa alcohol 1.84 Vitamin E acetate Acetate Fertility Hope 0.42 D, La- Tocopherol tocopherol 2% COMP. (V) 39.38 castor oil Castor (Ricinus Communis) oil A 6·00 hexadecanol polyoxyethylene ether WO 7 PEG-7 hydrogenated castor oil 2.00 Elfacos ST 9 PEG-45/dodecanediol copolymer 3.00 ten Tetrahydrous acid isopropyl g isopropyl myristate 8.00 jojoba oil% buy Yang (Hollywood) rod oil 4.00 Uvinul MC 80 Ethyl cinnamate ethyl hexyl ester 2.00 Uvinul A Plus Diethylamine Hydroxy-hydroxyl decyl hexyl benzoate LOO Abil 350 Dimethyl siloxane B 5.00 Z-COTE MAX Zinc oxide (and) diphenyl fluorenyl polyoxyalkylene 3.00 T-Lite SF Titanium dioxide, alumina Hydrate, Dimethicone/Oxapolyxane Copolymer C 0.20EdetaBD EDTA DiNan 5,00 Glycerin 87% Glycerol 0.30 Chemag 2000 Imidazopyridine urea 59.00 demineralized water (Water dem.) Demineralized water ( Aqua dem.) D full amount of essential oil 1% COMP. (Y) sufficient preservative 122883.doc -193· 200816981

0.50 Simulgel NS hydroxyethyl acrylate/propylene copolymer, angle 83⁄4 mineral water (Aqua dem.r~&quot; 61 · 10 demineralized water (Water dem.)

5.00T-Lite SF Oxidation, Emulsified Ming Hydrate '-Metite yttrium 10.00 Z-COTE N1AX Diphenyl phthalocyanine Polyoxane 12.00 Beeswax 3044 PH 8.00 Candi Rica 1^2811^ --^ Cerifera)) Wax 5.00 Tegin from ester SE ^--- 5.00 Dow Coming 345 Fluid, ring one by one ^ --------1 122883.doc -194- 200816981

5,00 WitconolAPM PPG-3 Tetraalkyl Ether 5.00 Softisan 154 Hydrogenated Palm Oil 8.00 Paraffin Oil, High Viscosity Mineral Oil 3.00 Vaseline Petrol 2% COMR(V) 32.00 Castor Oil Castor (Ricinus Communis) )) Oil 3.00 Uvinul MC 80 Ethylhexyl methoxycinnamate 2.00 Uvinul T 150 Ethylhexyltrimium 2.00 Uvinul A Plus Diethylaminohydroxyl-decylhexyl benzoate 10.00 Z-COTE MAX Oxidation Zinc (and) diphenyl fluorenyl polyoxyalkylene 12.00 Beeswax 3044 PH Beeswax 3.00 Vaseline petrol 8.00 Candidella wax LT 281 LJ Candelilla (Euphorbia Cerifera) 躐 8.00 stone Emu Oil, High Viscosity Mineral Oil 5.00 Tegin Glyceryl Stearate SE 5.00 Softisan 154 Hydrogenated Palm Oil 5.00 Witconol APM PPG-3 Tetrahydrofuryl Ether 5.00 Dow Coming 345 Fluid Ethanol, Cycloheximide Oxide 0.1% COMP.(V) 28.90 Castor (Ricinus Communis) Oil 5,00 T-Lite SF Titanium Dioxide, Oxidized Methane Oxide, Diterpene Oxygen Oxide/Polyoxime Copolymer 6.00 Finsolv TN ^benzoic acid C12-15 alkane 10.00 Uvmul MC 80 Ethylhexyl methoxycinnamate^ 6.00 Miglyol 812 Caprylic/capric acid diglyceride 5.00 ArlacelP 135 PEG-30 dipolyhydroxystearate~~· 2.00 Ganex V 216 PVP/16 Ene copolymer ~- 2.00 Elfacos ST 9 &quot;PEG-45/dodecanediol copolymer-- B 3.00 1,2-propanol care propylene glycol ~-- 0.10 EdetaBD EDTA disodium - 1.00 magnesium sulfate 7 · hydration Sulfuric acid town 59·40 Breaking water (Water dem.) Demineralized water (Aqua dem·) ' ^— 0.5% COMP. (V) Sufficient preservative '

Mercapto ether, cocoaglyceride, sorbitan &amp; sesquioleate, white bee sting, stearic acid, two

122883.doc 195- 200816981 Ester 1.00 Dehymuls PGPH Polyglyceryl-2 dipolyhydroxystearate 8.00 Finsolv TN C12-15 alkyl benzoate 4.00 Miglyol 812 Caprylic/capric acid triglyceride 4.00 Uvinul MC 80 Methoxy Ethyl cinnamate 2.00 Uvinul N 539 X Oaklin B 5.00 Z-COTE MAX Zinc Oxide (and) Diphenyldecyl Methane C 3.00 1,2-Propanediol Care Propylene Glycol 0.30 Abiol p Biting urea 1 〇〇 magnesium sulfate 7-hydrate sulphate ore to make up 100 demineralized water (Water dem.) demineralized water (Aqua dem.) 1.5% COMR (V) D sufficient preservative

A 4.00 Dehymuls SBL polyglyceryl-2 dipolyhydroxystearate, dioctyl ether, cocoaglyceride, sorbitan sesquioleate, white bee sting, stearic acid, dicocoa isoflavone Alcohol distearyl citrate 1.00 Dehymuls PGPH Polyglyceryl-2 dimerization stearate 8.00 Finsolv TN Benzoic acid C12-15 alkyl ester 4.00 Miglyol 812 Caprylic/capric acid triglyceride 4.00 Uvinul MC 80 methoxy cinnamic acid ethyl hexanoate 2.00 Uvinul N 539 T octoberin B 5.00T-LiteSF-S titanium dioxide, vermiculite hydrate, alumina hydrate, fluorene oxide/dimethicone Alkyne Copolymer C 3.00 1,2· Propylene Glycol Care Propylene Glycol 0.30 Abiol Miso Sigma-based Urea 1.00 Magnesium Sulfate 7-Hydrate Sulfate Town 1.0% COMP. (V) Make up 100 demineralized water (Water dem.) Demineralized water (Aqua Dem.) D sufficient amount of preservative A 4.00 Dehymuls SBL polyglyceryl 2 dimerized stearic acid vinegar, dioctyl decyl ether, cocoa glycerol g, sorbitan sesquioleate, white beeswax, stearin Aluminium sulphate, dicocoradyl isopentenate, distearyl sulfate 1.00 Dehymul s PGPH polyglyceryl 2 dimerization based stearic acid vinegar 8.00 Finsolv TN benzoic acid C12-15 alkyl ester ~ 4.00 Miglyol 812 Ί octanoic acid / citric acid diglyceride 8.00 Uvinul A Plus B methoxycinnamic acid B Hexyl hexyl ester and diethylamino hydroxy decyl hexyl benzoate 2.00 Uvinul N 539 T okelin 122883.doc -196- 200816981 c 3.00 1,2-propanediol care OOAbiol

B 5.00 Z-COTEMAX

A 4.00 Dehymuls SBL polyglyceryl-2 dimer hydroxy-&gt;--branched ether, cocoaglyceride, dehydrated 7 ^ sesquioleic acid vinegar, white bee, ^^ sugar alcohol cocoa isoprenyl _ = lemon

Octolide I Titanium Oxide, Alumina Oxygen Burning / Methyl Polyoxymethane Copolymer Propylene Glycol Met Poly C 3.00 1,2-Propanediol Care ~~030Abioi 10.00 Magnesium Sulfate 7-Hydrate ^ Foot 100 Demineralized Water (Water demT 0.2% COMP. (V) sufficient preservative ~

A 4.00 Dehymuls SBL

8.00 Finsolv TN

2.00UvinulN 539 TB 5.00 T-Litc SF-S C 3.00 1,2-propanediol care imidazolyl urea sulfate demineralized water (Aqua dem,) polyglyceryl-2 dimerization stearate, dimercapto Scale, cocoaglyceride, sorbitan &amp; sesquioleate, white beeswax, aluminum stearate, bis-isoprenyl alcohol distyryl citrate, glycerol-2 dimerization Hydroxybenzoic acid C12-15 alkyl ester; acid/capric acid triglyceride 'oxy succinic acid G base and phenyl hexyl benzoic acid, ai kelin, titanium oxide, shixi stone hydrate, oxidation Rabbit dioxoxane/dimethyl polyoxyalkylene propylene glycol ~ 'Matridine urea sulfate town 0.30 Abiol 1.00 琉 acid 7-hydrate

122883.doc -197- 200816981

Demineralized water (Aqua dem.) Preservative A 4.00 Dehymuls SBL Polyglyceryl-2 dipolyhydroxystearate, dioctyl ether, cocoaglyceride, sorbitan sesqui Acid ester, white beeswax, aluminum stearate, dicocoradyl isopentenyl alcohol distearyl citrate 100 Dehymuls PGPH polyglyceryl-2 dicarboxy carboxy stearic acid drunk 8.00 Finsolv TN benzoic acid C12- 15 Alcohol vinegar~'-~~ 4.00 Miglyol 812 Caprylic/capric acid triglyceride vinegar ^ — 7.00 Uvinul MC 80 Ethyl hexyl methoxycinnamate 2.00 Mexoryl XL _ cresol triazole oxime — B 5.00 Z -COTE MAX mono-oxidation, oxidized hydrate, diterpene polyoxymethane/copolyoxyalkylene copolymer C 3.00 1,2-propanediol care propylene glycol hydrazine 30Abiol imidazolidinyl urea... l.oo barium sulfate 7-hydrate Sulfuric acid town make up 100 demineralized water (Water dem.) Demineralized water (Aqua dem.) 0.01% COMP. (V) Foot 1 preservative A 7.50 Uvinul MC 80 Methoxycinnamate ethylhexyl ester 3.00 Uvinul N 539 T Oaklin...&quot;' 2,00 Uvinul A Plus monoethylaminohydroxybenzylidene hexyl methacrylate 1.00 Hexaol polyoxyethylene ether CO 40 PEG-40 hydrogenated castor oil 10,00 Miglyol 812 octanoic acid/capric acid triglyceride West 1.50 Dow Coming 345 Fluid cyclopentaoxane, cyclohexyloxane B 3.50 Luvigel EM octanoic acid / Tridecanoic acid triglyceride, sodium acrylate copolymer C 46.00 demineralized water (Water dem.) demineralized water (Aqua dem.) D 5.00 1,2-propanediol care propanol 0,50 hexadecanol polyoxyethylene ether A 25 Whale stearyl ether-25 * 0.05% COMP. (V) — 20.00 Ethanol 96% --- ------ A 1.00 Uvinul A Plus monoethylamino benzyl benzyl hexyl benzoic acid Ester 1.00 Tmosorb S bis-ethylhexyloxyphenol methoxy phenyl ^ 3.00 Uvmul MC 80 methoxy cinnamic acid ethylhexyl 8.00 Miglyol 812 Xin Yiwen / citric acid diglyceride vinegar ' 1.50 Dow Coming 350 Fluid Alkyl ^ ^ a 3.00 Z ^ -CO 1L · JMAX. Titanium oxide, alumina hydrate, two gas / polyacrylonitrile copolymer 3.00 Finsolv TN benzoic acid C12-15 alkyl ester ~ ^ ~ 122883.doc • 198- 200816981 1.00 Cetyl polyoxyethylene ether CO 40 PEG-40 hydrogenated castor oil B 2.00 LuvigelEM caprylic acid / capric acid triglyceride, sodium propionate Polymer C 54.80 demineralized water (Water dem.) demineralized water (Aqua dem.) D 15.00 ethanol 96% ethanol 5.00 1,2-propanediol care 1 propylene glycol 0.50 hexadecanol polyoxyethylene ether A 25 cetearyl alcohol Ether-25 1.0% COMP. (V) 1.00 Vitamin E Acetate Tocopherol 0.20 Racemic Bisphenol Alcohol A 4.00 Dehymuls SBL Polyglyceryl-2 Dipolyhydroxystearate, Dioctyl Ether, Cocoaglyceride, sorbitan sesquioleate, white beeswax, aluminum stearate, dicocoa isopentitol didistole citrate 1.00 Dehymuls PGPH polyglyceryl-2 dimer hydroxy hard Fatty acid ester ' ~ 6.00 Finsolv TN benzoic acid C1245 alkane 6 ^^- 6,00 Miglyol 812 octanoic acid / citric acid triglyceride ^ --- 5.00 Uvinul MC 80 methoxy cinnamic acid ethylhexyl ester '~ 3.00 Neoheliopan HMS Humosudate' — B 5.00 Z-COTE MAX Zinc Oxide (and) Diphenylsulfonylphosphonium; C 3,00 1,2-Propanediol Care Propylene Glycol '- 0.30 Chemag 2000 Miso Benzoyl - - 1.00 Magnesium Sulfate 7-Hydrate Magnesium Sulfate ^^^ 65.10 Demineralized Water (Water dem.) Demineralized Water (Aqua dem.) ^— 0 .1% COMP.(V) Foot 1 Preservative '^~—~ A 4.00 Tego Care 450 Polyglyceryl-3 Methyl Glucose - Hard Moon 4.50 Uvinul MC 80 Ethylhexyl methoxycinnamate^ 3.00 Uvinul N 539 T Oaklin ^ 2.00 Uvinul T 150 Ethylhexyl triazinone ^ 0·50 Vitamin E acetate '^ Acid fertility' ^ B 5.00 Isohexadecyl isohexadecene '~-S^ 3.50 Cetiol SN malic acid di-C12-13 alkyl ester isostanoic acid cetyl stearyl ester

1.00GanexV-220 5.00 T-Lite SF C 60.00 Water dem. 5^00 Glycerin 87% 1.00 Lanette E 0.30 Keltrol VP/Eicocarbene Copolymer Oxidation Oxide, Oxidized Methane, Trioxane/Oxygen Alkyl Copolymer Glycerol Whale Stearyl Stearyl Sulfate 7 Gum -199- 122883.doc 200816981

0.2% COMP.(V) D sufficient preservative A 4.00 Tego Care 450 Polyglyceryl-3methyl glucose distearate 4.50UvinulMC 80 Ethyl cinnamate ethylhexyl ester 3.00 UvimilN 539 T Oaklin 2.00 Neoheliopan HMS Humosulin 0.50 Vitamin E Acetate Tocopherol B 5.00 Isohexadecyl Hexadecane 5.00 Cosmacol EMI Malic acid di-C12-13 alkyl ester 3.50 Cetiol SN Isophthalic acid whale stearyl ester 1.00 Ganex V-220 VP/Eicosene Copolymer 5.00 I^LiteSF Titanium Dioxide, Alumina Hydrate, Dimethyl Oxide/Methyl Hexane Copolymer C 59.20 Demineralized Water (Water dem.) Demineralization Water (Aqua dem.) 5.00 Glycerin 87% Glycerin 1.00 Lanette E Cetearyl Stearyl Sulfate 0.30 Keltrol Sanxian Gum 1.0% COMP. (V) D Sufficient Preservative A 4.00 Tego Care 450 Polyglyceryl _3 曱Glucose distearate 4.50 Uvinul MC 80 Ethylhexyl methoxycinnamate 3.00 Neoheliopan OS Octyl salicylate 2.00 Neoheliopan HMS Humo Liu S 0.50 Vitamin E acetate Tocopherol B 5.00 isohexadecyl Hexadecane 5.00 Cosmacol EMI Malic acid di-C12-13 alkane Ester 3.50 Cetiol SN Isophthalic acid whale stearyl ester LOO Ganex V-220 VP / eicosene copolymer 5.00 Z-COTE MAX Zinc oxide (and) diphenyl fluorenyl fluorene C 60.15 off Mineral water (Water dem.) Demineralized water (Aqua dem.) 5,00 Glycerin 87% Glycerin 1.00 Lanette E Cetearyl sulphate 030 Keltrol Sanxian Gum 0.05% COMR(V) D sufficient preservative A 4.00 Tego Care 450 Polyglyceryl-3 Methyl Glucose Distearate 4.50 Uvinul N 539 T Oaklin 3.00 Neoheliopan OS Octyl Salicylate 2,00 Neoheliopan HMS Humosulin 0.50 Vitamin E Acetate Tocopherol B 5.00 isohexadecyl isohexadecane 122883.doc -200- 200816981

5.00 Cosmacol EMI 3.50 Cetiol SN Malic acid di-C1243 alkyl ester Isophthalic acid whale stearyl ester LOO Ganex V-220 VP/Eicosene copolymer

0.01% COMP.(V) D sufficient preservative A 4.00 Tego Care 450 λ cf\ ττ χτ con Τ'4 ^Glyceryl-3-mercaptoglucose ~ 4.50 Uvinul N 539 1 Oaklin--- 3.00 Neoneliopan Oh O AA Χ-ΤΛ/fC sour vinegar ^^- 2.UU Neoneliopan HM!S ^月莫柳酉之^^-0.50 vitamin E acetic acid ϊ ^ ^ acid fertility hope ^ --- B 5,00 different sixteen院院16院- 5.00 Cosmacol bMl 1|Acetic acid di-C12-13 alkane S ——— 3,50 Cetiol SN isophthalic acid cetyl stearyl ester ~- a LUU Cjanex V-22U c AA TP T 〇T? c ~ΫΡ/Eicosene copolymer ~^—— 5.00 1-Lite 〇r-〇C 59.20 demineralized water (Water dem.) Titanium oxide, vermiculite hydrate i, 曱聚石石氧Burning / Diterpene Copolymerization Mineral Water (Aqua dem.) ^^ 5.00 Glycerin 87% : ~—— 1.00 Lanette E Cetearyl Sodium Stearate-~- 0.30 Keltrol Dioxin--- 1.0% COMP. (V) D sufficient preservatives '^ A 8.00 Cetiol B Dibutyl adipate 8.00 Finsolv TN j citrate C12-15 alkane ~~&quot; 12.00 Myritol 331 Cocoa glyceride 1.00 Lanette E Cetearyl sulphate Sodium 4.00 Eumulgin VL 75 Lauryl Glycoside, Polyglycan Base-2 dimerization stearic acid vinegar, glycerol 2.00 Lanette 0 hexadecanol octadecyl alcohol 3.00 Tinosorb S bis-ethylhexyloxyphenol methoxy phenyl triazine 1.00 vitamin E acetate ~ tocopherol acetate B 4.00 Z-COTE MAX Zinc Oxide (and) Diphenyldecyl Methyl Polyoxane C 3.00 Glycerin 87% Glycerol 0.05 Edeta BD EDTA Erna 0.20 Allantoin Allantoin 0.30 Keltrol Sanxian Gum 1.50 Veegum Ultra 矽Magnesium aluminum oxide 122883.doc •201 - 200816981

49.45 demineralized water (Water dem.) demineralized water (Aqua dem·) 1.0% COMP. (Y) D sufficient preservative A 8.00 Cetiol B dibutyl adipate 8.00 Finsolv TN benzoic acid C12-15 alkyl ester 12.00 Myritol 331 Cocoglyceride LOO Lanette E Whale stearyl sodium sulfate 4.00 Eucumgin VL75 Lauryl sugar, polyglyceryl-2 dimerization stearate, glycerol 2.00 Lanette O Cetyl stearyl alcohol 3.00 Tinosorb S Bis-ethylhexyloxyphenylene methoxyphenyl trisodium 1.00 vitamin E acetate acetate tocopherol B 4.00 T-Lite SF titanium dioxide, alumina hydrate, dimethicone/oxygen Alkyne Copolymer C 3.00 Glycerin 87% Glycerol 0.05 Edeta BD EDTA Disodium 0.20 Allantoin Allantoin 0.30 Keltrol Dianthus 1.50 Veegiun Ultra ' ~- 50.25 Demineralized Water (Water dem.) Demineralized Water (Aqua dem.) A D 0.50 citric acid --- sufficient essential oil — one —. 0.2% COMR (V) foot @ Ρ six rot turtle 1 _ &quot; 1

2.50 T-Lite SF C 5.00 Glycerin 87% 2.00 Lanette E 0.30 Keltrol 1.00 Pationic 138 C 1.00 Pationic SSL Titanium Dioxide, Alumina Oxygen Burning / Polyoxyalkylene Copolymer Glycerin Gas 7, Harden Sodium Sulfate Laurel-based sodium lactate stearyl sulphate sodium lactate 42,00 demineralized water (Water dem.) demineralized water (Aqua dem.) D 5.00 Eusolex 232 phenyl benzo 1 ^ m 17 sitting acid 122883.doc -202- 200816981

10.00 demineralized water (Water dem.) demineralized water (Aqua dem.) E 0.70 sodium hydroxide sodium hydroxide 1.0% COMP. (V) sufficient preservative A 5.00 Cosmacol EMI fruit acid di-C12-13 alkyl ester 4.50 UvinulMC 80 Ethyl cinnamate ethylhexyl ester 3.00 UvinulN 539 T Oaklin _ 2.00 Uvinul A Plus Diethylaminohydroxybenzylidene hexyl benzoic acid Cool B 4.00 Tego Care 450 Polyglyceryl-3-mercaptoglucose Distearate 5·00 isohexadecane isohexadecene 3.50 Cetiol SN isodecanoic acid cetyl stearyl ester 0.50 vitamin E acetate &quot;' acetic acid fertility - 1.00 GanexV-220 ip / twenty carbon Ethylene Copolymer 2.50 T-Lite SF Titanium Dioxide, Oxidized Methane Oxide, Diterpene Oxygen Oxide/Polymerization Copolymer C 5.00 Glycerin 87% 2.00 Lanette E Cetearyl Sodium Sulfate 0.30 Keltrol Sanxian Gum 1.00 Pationic 138 C Laurel-based sodium lactate 1.00 Pationic SSL Stearic acid-based sodium lactate 41.00 demineralized water (Water dem.) Demineralized water (Aqua dem.) D 5,00 Eusolex 232 Phenylbenzimidazole sulfonic acid 2.0% COMP. (V) 10.00 demineralized water (Water dem·) demineralized water (Aqua dem.) E 0. 70 sodium hydroxide sodium hydroxide sufficient preservative A 5.00 Cosmacol EMI malic acid di-C12-13 alkyl ester 4.50 Uvinul MC 80 methoxy cinnamic acid ethylhexyl ester 3.00 UvinulN 539 T octoline 2.00 Uvinul A Plus II Ethylaminobenzyloxybenzylhexyl benzoate B 4.00 Tego Care 450 Polyglyceryl-3-mercaptoglucose distearate 5.00 isohexadecane Xhexyl 3.50 Cetiol SN Isophthalic acid cetyl stearate Base Ester 0.50 Vitamin E Acetate Tocopherol 1.00 Ganex V-220 VP/Eicosene Copolymer 2.50 Z-COTE MAX Zinc Oxide (and) Diphenyldecyl Methane Oxane C 5.00 Glycerin 87% Glycerin 2.00 Lanette E Whale Sodium Stearyl Sulfate 0.30 Keltrol Sanxian Gum 1.00 Pationic 138 C Laurel Sodium Lactate LOO Pationic SSL Stearic Acid Sodium Lactate 42.50 Demineralized Water (Water dem·) Demineralized Water (Aqua dem·) 122883. Doc -203 - 200816981

D 5.00 Eusolex 232 Phenylbenzimidazole acid 0.5% COMP.(V) 10.00 Demineralized water (Water dem.) Demineralized water (Aqua dem.) E 0.70 Sodium hydroxide 1 Sodium hydroxide sufficient preservative A 5.00 Cosmacol EMI Malic acid di-C12-13 alkyl ester 7.50 UvinulN 539 T Oaklin 2.00 Mexoryl XL Indophenol tromethamine trioxane B 4.00 Tego Care 450 Polyglyceryl-3 methyl glucose distearate 5.00 Cetane isohexadecene 3.50 Cetiol SN Isophthalic acid whale stearyl ester 0.50 Vitamin E acetate Tocopherol 1.00GanexV-220 VP/Eicocarbene copolymer 5.00 Z-COTE MAX Zinc oxide (and) Diphenyldecylmethylpolyoxyalkylene C 5.00 Glycerin 87% Glycerin 2.00 Lanette E Cetearyl Sodium Sulfate 0.30 Keltrol Sanxian Gum 1.00 Pationic 138 C Laurel Lactic Acid 1.00 Pationic SSL Stearic Acid Sodium Lactate 40.50 Demineralized water (Water dem.) Demineralized water (Aqua dem.) D 5.00 Eusolex 232 Phenylbenzopyranic acid 1.0% COMP. (V) 10,00 Demineralized water (Water dem.) Demineralized water ( Aqua dem.) E 0.70 sodium hydroxide sodium hydroxide sufficient preservative A 5.00 Cosmacol EMI Acid di-C12-13 alkyl ester 5.50 UvinulN 539 T Oaklin 2.00 UvinulAPlus Diethylamino hydroxy decyl hexyl benzoate 2.00 Mexoryl XL phenol phenol oxazole trioxane B 4.00 Tego Care 450 Polyglycerol Base-3 methyl glucose distearate 5.00 isohexadecyl isohexadecene 3.50 Cetiol SN isophthalic acid recorded stearyl ester 0.50 vitamin E acetate acetate tocopherol 1.00 Ganex V-220 VP/Twenty Carbene copolymer 5.00 Z-COTE MAX 1 Zinc oxide (and) Diphenyl fluorenyl fluorene C 5.00 Glycerin 87% Glycerin 2.00 Lanette E Cetearyl sulphate 0.30 Keltrol Sanxian 1.00 Pationic 138 C lauric acid sodium lactate 1.00 Pationic SSL stearyl sulphate sodium lactate 41.50 demineralized water (Water dem.) demineralized water (Aqua dem,) D 5.00 Eusolex 232 phenyl benzoate σ sit acid 122883.doc -204- 200816981

'0.5% COMP.(V) ' ~ 9.50 demineralized water (Water dem.) demineralized water (Aqua dem·) E 0.70 sodium hydroxide sodium hydroxide preservative A 5.00 Cosmacol EMI + malic acid di-C12- 13 alkyl ester ~ 5.50 UvinulN 539 T 3 gram stereotype '~~- _~ 2.00 Uvinul A Plus ~ diethylamino hydroxy benzyl hydrazine polymethyl hydrazine - 2.00 Mexoryl XL cresol trobamine = decane B 4.00 Tego Care 450 Polyglyceryl-3-mercaptoglucose distearate 5.00 isohexadecyl isohexadecene 3.50 Cetiol SN Isophthalic acid whale stearyl ester a 0.50 vitamin E acetate acetate tocopherol ... 1.00 GanexV- 220 ~ ΫΡ / eicosene copolymer - 5.00 T-Lite SF-S Titanium dioxide, vermiculite hydrate, alumina hydrate, ruthenium polyoxymethane / dimethicone copolymer C 5.00 Glycerin 87% Glycerin 2.00 Lanette E Whale Sodium Stearyl Sodium Sulfate 0.30 Keltrol Dianthan 1.00 Pationic 138 C Laurel Sodium Lactic Acid 1.00 Pationic SSL Stearic Acid Sodium Lactate 40.50 Dehydrated Water (Water dem·) Demineralized Water (Aqua dem. ) D 5.00 Eusolex 232 1 base benzimidazole sulfonic acid '~' 1.0% COMR(V) 10.00 Demineralized water (Water dem.) Demineralized water (Aqua dem.) E 0.70 Sodium hydroxide &quot; Sodium sulphate' 'Sufficient preservative A 8.00 Cetiol B Dibutyl adipate 8.00 Finsoiv TN C12-15 alkyl benzoate 10.00 Myritol 331 Cocoa glyceride 1.00 Lanette E good, sodium stearyl sulfate 4.00 Eumulgin VL 75 Laurel glycoside, polyglyceryl-2 dipolyhydroxystearate, glycerol 2.00 Lanette 0 Cetyl stearyl 1.00 Tinosorb S oxyphenol methoxy Phenyl phenyl ~ 1.00 Uvinul T 150 Ethylhexyl triterpene 1.00 Vitamin E acetate acetate Fertility B 5.00 T-Lite SF Titanium dioxide, alumina hydrate, dimethyl polyoxan / polymethoxane copolymerization C 3.00 Glycerin 87% Glycerol ~ 0.05 Edeta BD EDTA Erna ^ ' 0·20 allantoin 0.30 Keltrol 122883.doc -205 · 200816981

2.0% COMP.(V) 1.50 Veegum Ultra Shihic Acid Township Make up 100 demineralized water (Water dem.) Demineralized water (Aqua dem.) D sufficient amount of essential oils Preservatives A 8.〇〇CetiolB Dibutyl phthalate 8.00 Finsolv TN C12-15 alkyl benzoate 10.00 Myritol 331 Cocoa glyceride 1.00 Lanette E Cetearyl sulphate 4.00 Eumulgin VL 75 Lauryl glycoside, polyglyceryl-2 dipolyhydroxystearate , glycerol 2.00 Lanette 0 hexadecanol octadecyl 1.00 Tinosorb S bis-•ethylhexyloxyphenol decyloxy phenyl triazine 1.00 Uvinul T 150 ethylhexyl triazinone 1·〇〇 vitamin E acetate acetate Tocopherol B 5.00 Z-COTE MAX Zinc Oxide (and) Diphenylhydrazinium Polyoxymethane C 3.00 Glycerin 87% Glycerol 0.05 Edeta BD EDTA Disodium 0.20 Allantoin Allantoin 0.30 Keltrol Sanxianjiao 1.0% COMP.(V) 1.50 Veegum Ultra Magnesium aluminum silicate complements 100 demineralized water (Water dem.) Demineralized water (Aqua dem.) D sufficient amount of essential oils Preservatives A 3.00 Glycerin 87% 0.20 Edeta BD EDTA 〇.30Abiol Imidazolidinylurea 1.00 Plantacare 2000 j-glycoside &quot; 0.30 Keltrol T Sanxianjiao 57.00 demineralized water (Water dem.) demineralized water (Aqua dem.) B S.OOT-LiteSF-S titanium dioxide, Shishishi hydrate, alumina hydrate, cesium polyoxygen /Dioxane polyoxyalkylene copolymer C 7.50 Uvinul MC 80 Methoxycinnamate ethylhexanide 2.00 Uvinul A Plus _Diethylamino benzyl benzyl hexyl benzoate 2.00 Dow Coming 345 Fluid ring Hexane oxane 3.50 hexadecanol polyoxyethylene ether A6 whale stearyl ether-6, octadecyl alcohol ΰ hexadecanol polyoxyethylene ether A 25 cetearyl alcohol ether-2S 0·50 beeswax 3044 PH ~--- 3.00 Lanette 十六 Cetyl stearyl alcohol 10.00 Miglyol 812 octanoic acid / decanoic acid = acid glyceride D 1 · 〇〇 vitamin E acetic acid vinegar acetic acid growth 122883.doc -206· 200816981 2.0% COMP. (V) 0.20 racemic bisabolol

EpTA - Chaggose is reversed "mineral water" (Aqua dem〇 Sai stearyl alcohol mystery-6, octadecyl alcohol Double! Ester ether-25 A 3,00 glycerol 87% 0,20 EdetaBD 0·30ΑΜ〇Γ

1.00 Plantacare 2000 0.30 Keltrd T 58.00 Demineralized Water (Water dem.) B 5.00 Z-COTE MAX C~ 7,50UvinulMC80 2.00 Uvinul A Plus

2.00 Dow Coming 345 Fluid 3.50 Cetyl Polyoxyethylene Ether A 6 1,50 Cetyl Polyoxyethylene 0.50 Beeswax 3044 PH 10.00 Miglyol 812 D 1·00 Vitamin E Acetate\W〇COMR(V)&quot; 0 *20 racemic bisabolol j: hexacosanol __ acid glyceride acetate tocopherol chalcogen glycosides mineral water (Aqua dem,) _ f stone water copolymer methyl lactyl cinnamate B 2.00 Dow Coming 345 Fluid 7-methoxy bis-bisphedo-oxane, ring

122883.doc -207. 200816981

A 3.053⁄4•Oil 87% 0.20 Edeta BD 一甘$ '' -—— EDTA disodium 's---一- O.SOAbiol Imidazolidinyl urea '~----i ·ϋϋ JrC ^UUU ^—-- U3u Jveitrol i ^------ 2.00 Mexoryl SL base two camphor ^-~-- 58.40 demineralized water (Water dem.) t\i\ T *丄ot? 〇 dewatering water (Aqua dem.) -- — B 6.00 T-Lite SF-b Titanium Oxide, Vermiculite Hydroxyl Alcohol/Di-Methyl Copolymer 6.00 Uvmiil N 539 T 2.00 Parsol 1789 Occidental~1·~ 基二苯醯基歹^--- 2.00 Dow Coming 345 Fluid Cyclopenta sulphate, Cyclohexanthine gas burning 3,50 hexadecanol polyoxyethylene sulphide 8 6 gas sacrifice hard glutamate linkage-6, octadecyl alcohol 1.50 hexadecanol Ether A 25 Cetearyl alcohol-25 - 0.50 Beeswax 3044 PH ^- 3.00 Lanette 十六 Cetyl stearyl alcohol '~~ 10.00 Miglyol812 Caprylic/capric acid diglyceride &quot; D 1.00 Vitamin E acetate acetate Tocopherol 0.1% COMP. (V) 0.20 racemic biphasic alcohol Licohol -- A 3.00 Glycerin 87% i Oil --- 0.20 Edeta BD &quot;edtaZ^ 0.30Abiol Imidazopyridine urea 1.00 Plantacare 2000 3 glucoside - 0.30 Keltrol T Sanxian Gum 2.00 Mexoryl SL Benzene methylene dicamphorsulfonic acid 58.45 demineralized water (Water dem.) demineralized water (Aqua dem.) B 6.00 Z-COTE MAX zinc oxide (and) diphenyl fluorenyl polyoxyl 6.00 Uvinul N 539 T Oaklin 2.00 Parsol 1789 Butyl methoxy bis-mercapto methane 2.00 Dow Coming 345 Fluid Cyclopentaoxane, cyclohexanoxane _ 3,50 hexadecanol polyoxyethylene ether A6 Stearyl ether-6, octadecyl alcohol_1.50 hexadecanol polyoxyethylene ether A 25 whale butterfly stearyl ether-25 0.50 beeswax 3044 PH beeswax _ 3.00 Lanette 0 hexadecanol octanol 10.00 Miglyol 812 octanoic acid / Tridecyl citrate D 1.00 Vitamin E acetate Tocopherol acetate 0.05% COMR(V) 0.20 Racemic biphasic alcohol Myrrh A 3.00 Glycerin 87% Glycerin 0.20 Edeta BD EDTA Disodium 0.30 Abiol Imidazopyridine _ 122883.doc -208 - 200816981

1.00 Plantacare 2000 + thiol sugar---~-π 0.30 Keltrol T ~ Sanxianjiao^— 2.00 Neoheliopan AP The base is a savory succulent succulent acid nano-57.50 demineralized water (Water dem.) demineralized water AA dem. Dibenzyl carbene- 2.00 Dow Coming 345 Fluid Cyclopentaoxane, cyclohexyllithium ^]^ ~~- 3.50 hexadecanol polyoxyethylene oxime A 6 Record stearyl alcohol _-6, 18 酴~ 1.50 hexadecanol polyoxyethylene ether A 25 wax stearyl ether-25 ^ ~~- 0.50 bee soil 3044 PH bee 躐 ~ 3.00 Lanette 十六 hexadecanol octanol - 10,00 Miglyol 812 octanoic acid / citric acid Diacid glycerol 6 Ϊ 'one' - D 1.00 vitamin Ε acetate acetate fertility _ - 1.0% COMP. (V) ---- 0.20 racemic medicinal alcohol &quot;] medicinal alcohol ~~~ — A 25.00 Dow Coming 345 Fluid Cyclopentaoxane, Cyclohexanoxane ~ 20.00 Dow Coming 245 Fluid 3 Pentaerythritol Oxygen - 8.00 Uvinul MC 80 methoxy cinnamic acid ethyl hexate 4.00 Abil EM 90 Green 躐 ΡΕϋ PPG-lO/l二曱聚石々礼院 7.00 T-Lite SF Titanium Dioxide, Alumina Hydrate, Dimethoxy Oxide/Polyoxime Copolymer B 17.00 Ethanol 95% ~^Alcohol'---- 10.00 Z-COTE MAX Zinc Oxide (and) Diphenyl Anthraquinone Based Polysulfide 4.50 Demineralized Water (Water dem,) Demineralized Bay Water (Aqua dem.) 3.00 Glycerin 87% Glycerin 0.5% COMP.(V) 1.00 Talc It Stone A 25.00 Dow Coming 345 Fluid 螂 矽 矽 、 环 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 8.00 8.00 8.00 8.00 U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U U 90 4~lSPEG/PPCr-lU/l dimethyl sulphate oxygen 7.00 T-Lite SF-S Titanium dioxide, vermiculite hydrate, oxysulfide ^^, 曱 polyoxo/dioxane Take LB 17.00 Ethanol 95% Ethanol-- 9.99 Z-COTE MAX Zinc Oxide (and) a base bristles; 5.00 Demineralized Water (Water dem.) Demineralized Water (Aqua dem.) ' 3.00 Glycerol 87 % Glycerol----- 0.01% COMP.(V) 1.00 talc It stone '-^——122883.doc -209· 200816981

A 20.00 Dow Coming 345 Fluid 1 0 Dow Coming 245 Fluid Cyclopentaoxane 7.50 UvinulMC 80 Ethylhexyl methoxycinnamate 2.00 Uvinul T 150 Ethylhexyl triazinone 12.00 Cosmacol EMI Malic acid di-C12-13 alkyl ester 4,00AbilEM90 cetyl PEG/PPG-10/1 dimethylpolyoxane B 7.00T-LiteSF Titanium oxide, oxidized is hydrate, dimethicone /曱Polyoxyalkane Copolymer C 15.00 Ethanol 95% zlm~&quot; A 10.00 Z-COTE MAX Zinc Oxide (and) Diphenyldecyl Methyl Hexane 3.00 Glycerin 87% ' —- 1.5% COMP.( V) 8.00 demineralized water (Water dem.) demineralized water (Aqua dem.) A 20.00 Dow Coming 345 Fluid 裱 pentane oxime, cyclohexanoxane 10.00 Dow Coming 245 Fluid MJmWE --- 7.50 Uvinul MC 80 曱Ethylhexyl oxycinnamate 2.00 Tinosorb S Bis-ethylhexyloxyphenol methoxy stupid dioxime 12.00 Cosmacol EMI Malic acid di-C12-13 alkyl ester 4.00 Abil EM 90 Soil-based PEG/PPG-10 /1 dimethyl polychlorite 惫 B B 7.00T-LiteSF mono-oxidation, oxidized Ming hydrate, dimethyl poly-stone oxime / 曱 polyoxane物人C 15.00 Ethanol 95% ---- 10.00 Z-COTE MAX Zinc Oxide (and) Diphenyl Hydrazine 3.00 Glycerin 87% Glycerin 0.5% COMP. (V) 9,00 Demineralized Water (Water dem.) Mineral water (Aqua dem.) A 2.00 hexadecanol polyoxyethylene ether WO 7 PEG-7 hydrogenated linseed oil 6.00 Abil B 8839 S 矽 矽 sister, cyclohexan sulphur ^- 3.00 T-Lite SF I oxidized, oxidation # Lv Hydrate, Dimethicone/Polyoxyalkylene Copolymer, Human Co., Ltd., 4.00 isopropyl palmitate, isopropyl palmitate'- 1.00 Abil 350 1-polyoxyalkylene-B 7.00 Uvinul MC 80 曱Ethyl octyl oxycinnamate 1.00 Uvinul T 150 Ethylhexyl dioxin 7.00 Finsolv TN C12-15 alkyl benzoate ~- 4.00 Abil WE 09 Glyceryl-4 isostearic acid vinegar, humic PEG/ PPG-10/1 Dimethicone, hexyl laurate C 0.50 Sodium chloride - 0.20 Edeta BD EDTA Disodium - 61.30 demineralized water (Water dem.) Demineralized water (Aqua Dem.) D 1.00 vitamin E acetate acetate tocopherol-122883.doc -210- 200816981

1.0% COMP.(V) A sufficient amount of preservative A 2·00 hexadecanol polyoxyethylene ether WO7 PEG-7 hydrogenated sesame oil 6.00 AbilB 8839 cyclopentaoxane, cyclohexyloxane 3.00 Z-COTE MAX zinc oxide (and) Diphenyldecylmethylpolyoxyalkylene 4.00 isopropyl palmitate isopropyl palmitate 1.00 Abil 350 Dioxonium polyoxyalkylene B 7.00 UvinulMC 80 Ethyl cinnamate ethylhexyl acrylate - 1.00 UvinulT 150 Ethylhexyl hexane ketone 7.00 Finsolv TN benzoic acid C12-15 alkyl ester - 4.00 Abil WE 09 Polyglyceryl · 4 isostearic acid g, green soil based PEG / PPG-10/1 dimethyl fluorene Alkane, hexyl laurate C 0.50 sodium chloride sodium chloride --- 0.20 Edeta BD EDTA disodium - 62.20 demineralized water (Water dem.) demineralized water (Aqua dem.) D 1.00 vitamin E acetate acetate酴- 0.1% COMP.(Y) A sufficient amount of preservative A 2,00 hexadecanol polyoxyethylene ether WO 7 PEG-7 weathered castor oil 6.00 AbilB 8839 cyclopentamethoxy oxymethane, cyclohexyl lanthanide system ^^~- 3.00 Z-COTE MAX Zinc Oxide (and) Diphenyl Hydrazine 4,00 Palmitic Acid Isopropyl Palmitate Isopropyl 1.00 Abil 350 Dimethicone ~ One '- B 7.00 Uvinul MC 80 Methoxy Cinnamon Ethyl--- 1.00 Tinosorb S bis-ethylhexyloxybenzene - 7.00 Finsolv TN benzoic acid C12-15 alkyl ester ~~-- 4.00 Abil WE 09 — polysulfonyl-4 heterostearic acid| Purpose, rumors of its PE (fPG • Guanjiu oxygen = lauric acid 酉 酉 C 0.50 gasified sodium chloride - 0.20 Edeta BD Iedta disodium -~~-- 60.30 demineralized water (Water dem.) Demineralized shellfish (Aqua dem.)~—~ D 1.00 Vitamin E acetate acetate tocopherol~- 2.0% COMP.(V) Sufficient preservative A 2.00 Cetyl polyoxyethylene ether WO 7 PEG-7虱蓖麻油一'-.....- 6.00 AbilB 8839 Cyclopentate Oxygen Institute, Ring One - 6.00 Z-COTE MAX Benzene phenyl group 矽 焓 焓 4.00 isopropyl palmitate 1.00 Abil 350 Polyoxane~~~·- 122883.doc -211 - 200816981

A 2.00 hexadecanol polyoxyethylene ether WO 7 PEG-7 hydrogenated castor oil 6.00 AbilB 8839 cyclopentane oxime, cyclohexene oxynitride 6.00 Z-COTEMAX zinc oxide (and) diphenyl fluorenyl ruthenium Astaxantane 4.00 isopropyl palmitate isopropyl palmitate 1.00 Abil 350 Dioxon polyoxyalkylene B 3.00 UvinulN 539 T Oakley LOO MexorylXL 曱 phenol oxazole trioxane 1.00 Tinosorb S bis-ethyl Hexyloxyphenol methoxymethyl oxadiazine 7.00 Finsolv TN Benzoic acid C12-15 alkyl ester 4.00 Abil WE 09 Polyglyceryl-4 isostearate, whale PEG/PPG-10/1 dimethyl fluorene Oxyalkane, hexyl laurate C 0.50 Sodium chloride Sodium Chloride 0.20 Edeta BD ]DTA Erina ~ 1.0% COMP.(V) 61.30 Demineralized water (Aqua dem.) D 1.00 Vitamins E Acetate Tocopherol Toluene Preservative B 4.00 UvinulN 539 T Oaklin 1.00 Tinosorb S Bis-ethylhexyloxyphenol decyloxyphenyl ruthenium 7.00 Finsolv TN Benzoic acid C12-15 alkyl ester 4.00 AbilWE09 polyglyceryl-4 isostearate, whale-based PEG/PPG-10/1 dimethyl polyoxy siloxane, hexyl laurate C 0.50 sodium vaporization 0.20 Edeta BD EDTA disodium 62.10 demineralized water (Water dem·) demineralized water (Aqua dem.) D 1.00 vitamin E acetate acetate tocopherol... 0.2% COMP. (V) sufficient preservative A 2.00 cetyl alcohol Polyoxyethylene ether WO 7 PEG-7 hydrogenated sesame oil 6.00 AbilB 8839 cyclopentaoxane, cyclohexyloxane 6.00 T-Lite SF-S titanium dioxide, shixi stone hydrate, oxidized hydrate, 曱 polyoxyl Institute / Dimethicone Copolymer 4,00 isopropyl palmitate isopropyl palmitate 1.00 Abil 350 Dioxane polyoxyalkylene B 3.00 UvinulN 539 T Oakley 1.00 MexorylXL Indophenol tromethoxide Alkane 1.00 Tinosorb S Bis-ethylhexyloxyphenol decyloxymethyldiazine 7.00 Finsolv TN C12-15 alkyl benzoate 4.00 Abil WE 09 Polyglyceryl-4 isostearate, thiol PEG/PPG -10/1 dimercapto polyoxyalkylene, lauric acid 122883.doc -212- 200816981

&quot;ΐίΐ ^^ c 0.50 Sodium Chloride Sodium Chloride ^ 0,20 Edeta BD EDTA Er Na ^ 61.80 Demineralized Water (Water dem.) Demineralized Water (Aqua dem.) ~~^ D 1.00 Vitamin E Acetate _ acetic acid fertility 0.5% COMP.CV) sufficient preservative A 4.50 Uvinul MC 80 methoxycinnamic acid ethyl hexanoic acid 3.00 Uvinul N 539 T octoline ~ '~ - LOOUvimilTlSO Ethylhexyl sulphide S with ^ - 2.50 Cosmacol EMI Malic acid di-C12-13 alkyl ester ~ B 0,50 vitamin E acetate acetate tocopherol ^ — 4.00 Tego Care 450 Polyglyceryl-3 thioglycol-C 3.50 Cetiol SN Isophthalic acid whale Wax stearyl vinegar - 1.00 GanexV-220 VP / tens; ε anti-dilute copolymer ' 5.00 different 16 burning diced /, burning - 2.50 Cosmacol EMI malic acid di-C12-13 vinegar '^^^- 5.00 Z-COTE MAX Zinc Oxide (W) Diphenylsulfonyl D 44.00 Demineralized Water (Water dem·) Demineralized Water (Aqua dem.) ^ 5.00 Glycerin 87% Glycerin &quot;&quot;^ 1.00 Lanette E Recording wax hard ΐ ΐ 〜 ~ 15.00 Luviquat Care Quaternary Ammonium -44 ~ 1.0% COMR (V) 0.50 Keltrol Sanxian - E 1.00 Phenonip ------ A 4.50 Uvinul MC 80曱oxycinnamic acid ethyl hexanoic acid &quot; — 3.00 UvimilN 539 T Aokeli ^ 1.00 Tinosorb S bis-ethoxyhexyloxyphenol formazan 2.50 Cosmacol EMI Malic acid two culverts - B 0.50 vitamin E acetic acid Ester acetate tocopherol ^~ 4.00 Tego Care 450 Poly-oil base 3 methyl word sugar. A hard moon acid g Xiao C 3.50 Cetiol SN isocyanate cetearyl ester - 1.00 Ganex V-220 VP / Twenty i dilute copolymer ^- 5,00 isohexadecane iso-/, burn &quot;&quot;~~ ^ 2.50 Cosmacol EMI frequency-acid di-C12-13 burnt &quot;&quot;^ 5.00 Z-COTE MAX oxidation Zinc (and y diphenyl i醯 曱 D 44.90 demineralized water (Water dem.) 5.00 glycerol 87% demineralized water 〇 ^1 ^ dem.) ---- glycerin &quot;^^^ 1.00 Lanette E 15.00 Luviquat Care cetyl stearin i sodium sulfate ^ poly four-level bond ~~ ~~~ —— 0.1% COMP.(V) 1—f 11 1 — 0.50 Keltrol Dixian gum----__________*______ 122883.doc • 213· 200816981

E 1 ·00 Phenonip A 1.50 Mexoryl XL Methotrexate Trioxane 5.00 UvinulN 539 T Oaklin __ 1 ·00 Tinosorb S Bis-ethylhexyloxyphenol decyloxy phenyl triazine 2.50 Cosmacol EMI Malic acid di-C12-13 alkyl ester-B 0.50 vitamin E acetate acetate tocopherol 4.00 Tego Care 450 polyglyceryl-3 methyl glucose distearate C 3.50 Cetiol SN isocyanate whale stearyl ester 1.00 GanexV-220 VP/Eicosene Copolymer 5.00 Isohexadecylisohexadecane 2.50 Cosmacol EMI Malic acid di-C12-13 alkyl ester 5.00 Z-COTE MAX Zinc oxide (and) diphenyl fluorenyl Methyl polyoxyalkylene D 44.50 demineralized water (Water dem·) demineralized water (Aqua dem.) 5.00 glycerin 87% glycerol 1.00 Lanette E cetearyl sulphate 15.00 Luviquat Care poly quaternary ammonium -44 1,5 % COMR(V) 0.50 Keltrol Sanxian E 1.00 Phenonip A 1.50 Mexoryl XL Methotrexate Trioxane 5.00 UvinulN 539 T Oaklin 1.00 Tinosorb S Diethylhexyloxyphenol methoxyphenyl III Bismuth 2.50 Cosmacol EMI Malic acid di-C12-13 alkyl ester B 0.50 vitamin E acetate acetate tocopherol 4.00 Tego Care 450 Polyglyceryl-3-mercaptoglucose distearate C 3.50 Cetiol SN Isophthalic acid cetylstearyl 1.00 Ganex V-220 VP/Eicocarbene Copolymer 5.00 Isohexadecane Hexane 2.50 Cosmacol EMI Malic acid di-C12-13 alkyl ester 5.00 T-Lite SF Titanium dioxide, alumina hydrate, dimethicone/a polyoxyalkylene copolymer D 45.00 demineralized water (Water dem.) Demineralized water (Aqua dem.) 5.00 Glycerin 87% Glycerin 1.00 Lanette E Cetearyl sulphate 15.00 Luviquat Care Polytetramine-44 1.0% COMP. (V) 0.50 Keltrol Sanxian E 1.00 Phenonip A LOO Abil Care 85 double-PEG/PPG-16/16 PEG/PPG-16/16 diterpene polyoxylate, caprylic/capric acid triglyceride, 3.00 cetyl polyoxyethylene ether CO 40 PEG-40 hydrogenated hydrazine Sesame oil 0.30 hexadecanol polyoxyethylene ether WO 7 PEG-7 hydrogenated sesame oil •214-122883.doc 200816981

A 2.00 Abil Care 85 Bi-PEG/PPG-16/16 PEG/PPG-16/16 Dioxopolyoxane, caprylic/capric acid triglyceride 4.00 Finsolv TN Benzoic acid C12_15 alkyl ester 1.50 Miglyol812 Octanoic acid/癸Acid Triglyceride S 0.50 Vitamin E Acetate Tocopherol 7.50 Uvinul MC 80 Ethylhexyl methoxycinnamate 4.00 Cetiol B Dibutyl adipate 3.00 Luvitol EHO Ethyl caproate cetyl stearyl ester 1.00 Cetyl polyoxyethylene ether CO 40 PEG-40 hydrogenated castor oil 1.00 paraffin oil, low viscosity mineral oil 3.00 Plantacare 2000 癸 糖 glycoside 0.50 Phenonip sufficient essential oil B 4.00 Z-COTE MAX zinc oxide (and) diphenyl Mercapto polyoxyalkylene C 2.00 Simulgel NS hydroxyethyl acrylate / taurine acryl dimethyl dimethyl copolymer, squalane, polysorbate 60 0.20 Keltrol Sanxian 0.10 Edeta BD EDTA disodium 1.0%COMP.(V) 64·20 Demineralized water (Water dem·) Demineralized water (Aqua dem.) 5.00 Uvinul MC 80 Ethylhexyl methoxycinnamate 10.00 WitconolAPM ITG-3 Fourteen bases 2.00 Uvinul T 150 Ethylhexyltriazine with 1.00 Dow Coming 345 Fluid Oxyalkane, cyclohexyloxane 5.00 Uvinul N 539 T Oaklin B 5.00 Z-COTE MAX Zinc Oxide (and) Diphenyldecyl Methane C 5.00 1,2-Propanediol Propylene Glycol 0.20 Keltrol III Sinac O.lOEdeta BD EDTA disodium 2.0% COMP. (V) 1.50 Simulgel 600 acrylamide/acrylic dimethyl geranyl sulphate copolymer, isohexadecane, polysorbate 80 58.40 Demineralized water (Water dem.) Demineralized water (Aqua dem.) D sufficient amount of essential oil 0.50 glidant DMDM carbendazim A 6.00 Gilugel SIL5 cyclodecene polyoxane (and) aluminum hydroxide / magnesium hydroxide Stearate 5.00 Uvinul MC 80 Ethyloxycinnamate Ethylhexyl Ester 2.00 Uvinul A Plus Diethylaminohydroxyl-decylhexyl benzoate LOO Uvinul T 150 Ethylhexyltriazinone 7.00 Finsolv TN Benzoic acid C12-15 alkyl ester 4.00 Abil WE 09 polyglyceryl-4 isostearate, cetyl group 122883.doc • 215· 200816981

A 4.50 Uvirnil MC 80 Ethyl hexyl cinnamate ethyl hexyl 2.00 Tinosorb S bis-ethylhexyloxyphenol decyloxy styryl triazine 3.00 Uvirnil N 539 T ~ 'Octoline 2.50 Cosmacol EMI Malic acid II C12-13 alkyl ester 0.50 vitamin E acetate tocopherol 4.00 Tego Care 450 polyglyceryl-3 methyl glucosamine distearate BB 3.50 Cetiol SN isophthalic acid cetyl stearyl 1.00GanexV- 220 VP/Eicosene Copolymer 5.00 Isohexadecylisohexadecene 2.50 Cosmacol EMI Malic acid di-C12-13 alkyl ester 3.00T-LiteSF Titanium dioxide, oxidized Ming hydrate, diterpene concentrating oxygen / 曱Polyoxane Copolymer C 5.00 Glycerin 87% Glycerin 1.00 Lanette E Cetearyl Stearyl Sulfate 0.50 Keltrol Sanxian Gum 1.0% COMP. (V) 59.70 Demineralized Water (Water dem.) Demineralized Water (Aqua dem· D 1.00 Phenonip 0.30 racemic bisabolol PEG/PPG-10/1: methicillin, hexyl laurate 2.00 Cosmacol EMI malic acid mono-C12-13 alkyl ester — _ 3. palmitic acid Isopropyl isopropyl vinegar - 5.00 AbilB 8839 Cyclopentaoxane, cycloheximide ^1' · 0.50 Abil 350 ^ Polyoxyalkylene ' ' B 0.50 sodium chloride sodium chloride ~~ 0.20 Edeta BD EDTA disodium 0.2% COMP. (Y) 62.10 demineralized water (Water dem.) demineralized water (Aqua dem.) C 1.00 vitamin E Acetate Tocopheryl acetate _ 0.50 Phenonip A 2.00 Abil Care 85 Bi-PEG/PPG-16A6 PEG/PPG-16/16 Diterpenoids, octanoic acid/capric acid triglyceride 4.00 Finsolv TN Benzoic acid C12-15 alkyl ester 1.50 Miglyol 812 octanoic acid/capric acid triglyceride 0.50 vitamin E acetate acetate tocopherol 7.50 Uvinul MC 80 Methoxycinnamate ethylhexyl ester 4.00 Cetiol B Dibutyl adipate LOO Luvitol EHO Ethylhexanoate cetyl stearyl ester 1,00 hexadecanol polyoxyethylene ether CO 40 PEG-40 hydrogenated castor oil 1.00 scorpion oil, low viscosity mineral oil 3.00 Plantacare 2000 癸 糠 糠 ... ... 122883.doc -216- 200816981 1.00 Uvinul A Plus monoethylaminohydroxybenzylidene hexyl 0.50 Phenonip 2.50 Uvinul T 150 Ethylhexyl bismuth S with ~ Fully edulis oil - Β 4.00 Z-COTE MAX Zinc Oxide (and) Diphenyldecyl Methane C 2,00 Simulgel NS Hydroxyethyl Acrylate / Acryl Group Terpolymer, squalane, polysorbate 醢龅μ' ~ - 丘二钠 ~ 2^ 0.10 Keltrol ^ 0.10 EdetaBD — 0.5% COMP. (Y) ^ J 7 · 71/^ 贝 /, VV UC1I1 · j - -- Aqua dem. ^ A 4.00 Eumulgin VL 75 2.00 Lanette O 12.00 Myritol 331 8.00 Finsolv TN 8.00 CetiolB B 6.00 T^Lite SF 5.00 Z-COTE MAX C 3.00 Glycerin 87%&quot;&quot; 0.10 EdetaBD 1.50 Veegum Ultra 1.50 Lanette E 2.0% COMP. (V) 0.30 Keltrol Glycosylglycoside, polyglyceryl-2 dimerization ester, glycerol stearyl alcohol 1 glyceride 1 ¥ acid (: 12-15 alkyl ester 17 Diacid dibutyl vinegar EDTA disodium &gt; magnesium magnesium sulphate 7, sulphate sodium sulphate: sucrose ¥ oxyethanol, p-methyl benzoic acid ethyl hydroxybenzoate, butyl p-hydroxybenzoate, Propyl p-hydroxybenzoate, isobutyl p-hydroxybenzoate

A 4.00 EumulginVL 75 lauryl glycoside, ~ polyglyceryl-2 dimerate, glycerol

122883.doc •217· 200816981

1.50 Lanette E Whale Sodium Stearate 030 Carbopol Ultrez 10 P Carbomer 1.0% COMP. (V) 46.10 Demineralized Water (Aqua dem.) D 1.00 Phenonip Phenoxyethanol, Methyl p-hydroxybenzoate, ethyl p-hydroxybenzoate, butyl p-hydroxybenzoate, propyl p-hydroxybenzoate, isobutyl p-hydroxybenzoate A 4.00 Eumulgin VL 75 a &quot; [lauryl glycoside, Polyglyceryl-2 dipolyhydroxystearate, glycerol 2.00 Lanette 十六 Cetyl stearyl alcohol 10.00 Myritol 331 Cocoa glyceride 8.00 FinsolvTN 8,00 Cetiol B Dibutyl adipate B 2.00 Uvinul A Plus _ 2胺 羟基 羟基 5.00 5.00 5.00 5.00 5.00 5.00 5.00 5.00 Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z Z ega eta ega ega ega ega ega ega ega ega ega ega ega ega ega ega ega Magnesium silicate magnesium __ 1.50 Lanette E gas?, % stearyl sulphate 5.0% COMP. (V) 0.30 Carbopol Ultrez 10 P carbomer to make demineralized water (Water dem.) D 1.00 Phenonip acetonyl ethanol, Methylparaben, ethyl p-hydroxybenzoate, p-hydroxy Acid butyl ester, propyl paraben, methyl paraben

122883.doc •218- 200816981

D 1.00 Vitamin E Acetate Acetate &quot; η 0.20 Racemic Bisphenol Alcohol--- A 10.00 UvinulAPlusB Ethyl cinnamate ethyl hexyl ester, dihydroxybenzyl hexyl benzoate soil 10.00 UvinulN 539 T Oaklin--~4.00 Eumulgin VL 75 lauryl glycoside, polyglyceryl-2 diester, glycerol ~ 8.00 CetiolB dibutyl hexanoate _ - 8.00 Finsolv TN Benzoic acid C12-15 alkane Ester - 12.00 Myritol 331 Cocoa Glycerin 1.00 Lanette E Cetearyl Sodium Sulfate--- 2.00 Lanette 0 Cetyl Alcoholic Acid '-- B 3.00 Z-COTE MAX Zinc Oxide (and) Diphenylanthracene基曱运— C 35.08 demineralized water (Water dem.) demineralized water (Aqua dem.) ~ 0.38 citric acid-- 2.9 glycerol 87% glycerol - 0.05 Edeta BD EDTA disodium ~ - 0.20 allantoin urine Cysticin - 0.30 Keltrol - Sanxian Gum &quot; ~-- 0.1% COMP. (V) 1.50 Veegum Ultra Sodium Magnesium Citrate ~ - D 0.50 Phenonip ---- 1.00 Vitamin E Acetate Tocopherol Acetate &quot; --- A 0.70 hexadecanol polyoxyethylene ether A25 wax stearyl ether-25 1.70 hexadecanol polyoxyethylene ether A6 cetyl hard fat Ether-6, octadecyl alcohol ~ a 2.00 Uvinul APlus diethylamino benzyl benzyl benzyl ketone 3.00 Uvinul N 539 T octoline 3.00 Z-COTE MAX zinc oxide (and) diphenyl fluorenyl poly 2.00 AbilB 8843 PEG-14 dimethylpolyoxymethane ^. 3.60 Lanette 0 hexadecanol octadecyl ' --- 4.00 Uvinul MC 80 methoxycinnamate ethylhexyl ester ^-- 2.00 Cetiol B dibutyl hexanoate ~--- B 4.00 Glycerin 87% Glycerin^—0.20 Edeta BD EDTA Erna, s—71 ·00 Demineralized water (Water dem.) Panditol ~---- C 4.00 Luvigel EM octanoic acid/capric acid triacid Glyceride, propyl D LOO vitamin E acetate acetate tocopherol &quot;~^~ 1.0% COMP.(V) 0.20 racemic bisabolol myrrh alcohol &quot;&quot;^--^ sufficient preservative- ---- 122883.doc -219- 200816981

A 7.50 Uvinul MC 80 Ethylhexyl methoxycinnamate 5.00 UvinulN 539 T Oaklin 3.00 Emulgade PL 68/50 Whale stearyl glycoside, hexadecanol 18 醢 2.00 Dracorin 100 SE Stearic acid glycerin i PEG-100 stearic acid cool 1.00 Fitoderm 0.50 hexadecanol polyoxyethylene ether WO 7 chemical castor oil ' 〇 · 50 hexadecanol polyoxyethylene ether PS 20 '^ sorbitol ester 20 &quot; 2.00 Dry Flo Pure Powder-killing octenyl succinate B 5.00 Z-COTE MAX Zinc oxide (and) Diphenyl fluorenyl hydrazine Hydrazine 0.03 Sicomet Blue P 77 007 C· I· 77 007, Dark Blue C 4.00 1,2- Propylene glycol care propylene glycol 2.00D · ubiquinol 50P ubiquinol, propylene glycol 0.20 Keltrol ~--- 0.50 Simulgel 600 acrylamide / acryl fluorenyl fluorenyl sulphate copolymer, isohexadecane, polysorbate 80 0.5% COMP.(V) 65.27 demineralized water (Water dem.) demineralized water (Aqua dem.) sufficient preservative 0.50 vitamin E acetate acetate

A 6.00 Gilugel SIL 5 Cyclophosphazene (and) Aluminium Hydroxide / Magnesium Hydroxide Stearate. 5.00 UvinulN 539T ^7 Lilin ~~' ^ 2.00 Mexoryl XL Methotrexazole Trioxane 1.00 Uvinul T 150 Ethylhexyl triazinone 3.00 T-Lite SF-S Titanium oxide, Shishishi hydrate, oxidized Mingshui, methacrylate/dimethicone copolymer 5.00 Finsolv TN benzoquinone Acid C12-15 alkyl ester 4.00AbilWE09 Polyglyceryl-4 isostearate, nymphetyl PEG/PPG-10/1 dimethyl polyoxy siloxane, hexyl laurate 2.00 Cosmacol EMI Malic acid di-C12-13 Alkyl ester 3.00 palmitic acid isopropyl palmitic acid isopropyl alcohol 5.00 AbilB 8839 cyclopentaoxane, cyclohexanoxane 0.50 Abil 350 dimethylpolyoxyalkylene B 0.50 sodium hydride - 0.20 Edeta BD EDTA disodium 1.0 % COMP.(V) 61.30 Demineralized Water (Water dem.) Demineralized Water (Aqua dem.) C 1.00 Vitamin E Acetate Tocopherol 0.50 Phenonip A 1.00 Abil Care 85 Double-PEG/PPG-16/16 PEG /PPG-16/16 Dimethicone, octanoic acid/capric acid triglyceride 122883.doc -220- 200816981 3·00 hexadecanol polyoxyethylene ether CO 40

0.30 hexadecanol polyoxyethylene ether WO 7 Too Uvinul N539T PEG-40 hydrogenated castor oil PEG-7 hydrogenated castor oil oklilin 10.00 Witconol APM T〇OUvinulT150 PPG-3 tetradecyl ether

5·00 1,2-propanediol ~α20 Keltrol gdiol 0.10 Edeta BD 1.0%~CQMP.(V) 1.50 Simulgel 600 59.40 demineralized water (Water dem.) EDTA di-n-propyl per-amine/acrylic ruthenium ▲ Qiu _^Do, different 16 burning, polysorbate 8〇

D sufficient amount of essential oil 〇·50 glidant demineralized water (Aqua dem.) DMDM carbendazim A 7.00UvinulAPlusB methoxy cinnamic acid ethyl has 8, diethylamino group benzyl hexyl hexyl benzene Formic acid Cool 1.00 Tinosorb S Ethylhexyloxyphenol methoxy 1 篡 唪 1.00 UvinulT 150 Ethylhexyl = 嘻嗣 7.00 Uvinul N 539 T Clinin 4.00 Eumulgin VL 75 Lauryl glycoside, polyglyceryl-2 dimerization Hydroxy Stearate, Glycerin 8.00 Cetiol B Dibutyl Adipate 8.00 Finsolv TN C12-15 alkyl benzoate 12.00 Myritol 331 Glycerin 1.00 Lanette E Whale Stearic Sodium Sulfate 2.00 Lanette O Cetyl Alcohol Octaol B 3.UU Ζί-OD JL ϋ ΜΑλ Zinc Oxide (and) Diphenyldecyl Methyl Polyoxane C 35.35 Demineralized Water (Water dem·) Demineralized Water (Aqua dem.) 3.00 Glycerin &amp; 7% Glycerol 0.05 Edeta BD EDTA Erna 0.20 Allantoin Allantoin 0.30 Keltrol Sanxian 0.1% COMP. (V) 1.50 Veegum Ultra Magnesium Aluminum Citrate D 0.50 Phenonip 1.00 Vitamin E Acetate Acetate A 7.00 Uvinul A Plus B Methyl cinnamate ethyl hexyl ester, diethylamino hydroxy Yue cyclohexylbenzene section acyl ester 1.00 Tinosorb S group methoxyphenyl triazine 122883.doc -221- 200816981

LOO Uvinul T 150 '~~' _Ethylhexyl bismuth _ &quot;--- 7.00 UvinulN 539 T ~ 4.00 Eumulgin VL 75 Lauryl glycoside, polyglyceryl-2 dimerization , glycerin 8.00 Cetiol B hexanoic acid-butyl ester ~ 8.00 Finsolv TN 12.00 Myntol 331 1 i\f\ T jj τρι by vinegar ^^ LOO Lanette E r\ r\r\ τ AM /^v cetylstearyl sulfate Sodium - 2.00 Lanette O Decyl stearyl alcohol B 5.00 T-Lite SF Titanium oxide, alumina hydrate, metformite ^ Oxime / hydrazine polyoxyalkylene copolymer C 30.45 demineralized water (Water dem.) Aqua dem. 3.00 Glycerin 87% C\ f\C TT^ Λ 丄τ^ΊΓΧ Glycerin — 0.05 Edeta BD edta One nano ~ 0.20 allantoin Λ O rv Τ, 1 丄 1 &quot; ~ — 0.30 Keltrol &quot; ——— 5.0% COMP.(V) 1.50 Veegum Ultra Magnesium Aluminum Citrate - D 0.50 Phenomp 1,00 Vitamin E Acetic Acid Tocopherol Tobacco ~~ One 5.00 Z-COTE MAX Zinc Oxide (and ) phenyl fluorenyl fluorene 2.00 Uvinul A Plus monoethylamino hydroxy benzyl hexyl phenyl hydrazine per ^ - 2.00 Mexoryl XL cresol terazoate oxime a 3.00 Uvinul MC 80 Ethylhexyl methoxycinnamate 0.50 Abil 350 1-polyoxyalkylene--- 2.75 Carnival wax LT 20 Brazilian palm (Brazilian wax palm leaf) wax, paraffin 3.70 Candidella wax LT 281 LJ Candeli Ua (Euphorbia Cerifera) wax 1.80 bee sting 3050 PH ~-- 3.20 TeCero soil 30445 - microcrystalline 堰 ~ --- 3.20TeCero wax 1030K i ant ant ~ - 1.34 Cutina CP palmitic acid Cetyl ester 6.40 Vaseline 1 广脂&quot; — 7.30 Softisan 100 Hydrogenated cocoa glyceride 10.00 Luvitol EHO Ethyl hexanoate whale stearyl ester 0.17 natural bisabolol myrrh alcohol 1.84 Vitamin E acetate acetate tocopherol 1.0% COMP.(V) 0·42 D, La-fertility to child age~&quot; 40.38 million sesame oil ramie ((Jastor) (Rieinus Communis) oil 122883.doc • 222· 200816981

69·50 demineralized water (Water dem.) D sufficient amount of essential oil five 50 glidant propylene amide amine dimercapto burdock ^1 ^ ± ^ burning, polysorbate '80, with mineral water (Aqua dem .) DMDM

A 1.00 Abil Care 85 &quot;ioo cetyl polyoxyethylene ether CO 40 penta 30 hexanol polyoxyethylene ether WO 7 T.00 Parsol 1789 T.00 Mexoryl XL —10.00 WitconolAPM ^-PEG/PPgTi6/16 PEG/ PPG-16/16Zf· only shi eric acid triglyceride PECMOj^ sesame oil based methoxy boxing two 醯 曱 曱 甲 甲 盼 坐 坐 p sitting three j 氯 chlorinated PPG-3 fourteen burning _

1.00 Dow Coming 345 Fluid —5.00 UvinulN 539 T Ethylhexyl Trip Gent 嗣 矽 矽 矽 矽 、 、 、 、 、 、 奥 奥 奥 奥 _ _ _ _ _ _ _ _ _ _ _ _ _ _

C 5.00 1,2-propanediol 1.00 Mexoryl SX 0.20 Keltrol O.lOEdetaBD 0.2% COMR(V)~ 1.50 Simulgel 600 68.30 demineralized water (Water dem.) D sufficient amount of essential oil 0.50 glidant propylene glycol oxymethane / dimerization矽 烷 共聚物 身 身 身 一 ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED ED Mineral water (Aqua dem·) DMDM 乙 醯 urea 122883.doc -223 - 200816981

A 0·70 hexadecanol polyoxyethylene ether A25 堰 stearyl ether-25 1.70 hexadecanol polyoxyethylene ether Α 6 whale stearyl ether-6, octadecyl alcohol 2.00 Parsol 1789 butyl methoxy bisphenol Methane 5.00 UvinulN 539 T Oaklin - 4.00 Z-COTE MAX Zinc Oxide (and) A 荃 聚 聚 2.0 2.0 2.0 2.0 2.00 Abil B 8843 PEG-14 Dioxane 3.60 Lanette 0 Cetyl alcohol Octaol 1.00 Uvinul T150 Ethylhexyl Trioxanone 2.00 CetiolB Dibutyl Badiate B 4.00 Glycerin 87% Glycerol '~ &quot;' 0.20 Edeta BD EDTA Steel 71.00 Demineralized Water (Water dem.) Ubiquinol 'C 4.00 Luvigel EM octanoic acid/capric acid triglyceride, sodium acrylate copolymer 1.0% COMP. (V) D 1.00 vitamin E acetate acetic acid growth age 0.20 racemic bisabolol myrrh alcohol sufficient preservative A 1.00 Abil Care 85 bis-P^G/PPG-16/16 PEG/PPG-16/16 Diterpenoids, octanoic acid/capric acid: glycerol glycerate 3.00 hexadecanol polyoxyethylene ether CO 40 PEG-40 Hydrogenated castor oil 0.30 hexadecanol polyoxyethylene ether WO 7 PEG-7 hydrogenated lotus oil 2.00 Parsol 1789 Butyl methoxy dibenzyl hydrazine methane 2.00 Mexoryl XL Phentrozole trioxime 10.00 WitconolAPM PPG-3 tetradecyl ether 1.00 UvinulT 150 Ethylhexyl triazinium with 1.00 Dow Coming 345 Fluid 裱 矽 矽 环 5.00 5.00 UvinulN 539T Oaklin B 3.00 Z-COTE MAX Zinc Oxide (and) Diphenyl Mercaptopurine Polyoxaxane C 5.00 1,2-Propanediol Propylene Glycol 1.00 Mexoryl SX P-Benzyl Methylene Diernetic Acid 0.20 Keltrol Dioxin _ 0.10 Edeta BD EDTA Disodium 1.50 Simulgel 600 Acrylamide/Propylene Tomb Dimercaptosodium Taurate Copolymer, Isohexadecane, Polysorbate 80 0.5% COMP. (V) 68.00 Demineralized Water (Water dem· Demineralized water (Aqua dem.) D sufficient amount of essential oil 0.50 glidant dmdm carbendazim A 2.00 Uvinul A Plus monoethylamino hydroxy decyl hexyl benzoic acid _ 3.00 UvinulN 539T Oakley 122883. Doc -224- 200816981 3.00 Emulgade PL 68/50 Whale soil stearyl glycoside, hexadecanol octanol 2.00 Dracorin 100 SE glyceryl stearate, PEG-100 stearate 1.00 Fitoderm _ 0.5 hexadecanol polyoxygen Vinyl ether WO 7 Ρϋϋ-7 hydrogenated cannabis oil 5 · hexadecanol polyoxyethylene ether PS 20 Polysorbate 20 2.00 Dry Flo Pure ; Hall Powder Octenyl Succinate B 5.00 Z-COTE MAX Zinc Oxide (and) Diphenyl Hydrazine 曱 曱 曱 夕 夕 C C 4·〇〇1, 2-propanediol care propylene glycol --- 0.20 Keltrol Sanxianjiao --- 0.50 Simulgel 600 internal ene amide / propylene dimethyl diol, isohexadecane, polysorbate 80, 65.80 demineralized water (Water dem ·) demineralized shellfish (Aqua dem.) D 0.50 Euxyl K 300 0.50 vitamin E acetate acetate tocopherol - 1.0% COMP. (V) l.OORetiSTAR caprylic/capric triglyceride, tocopherol, reticulum alcohol

Example 34 The oxidation resistance of 3,3'. dihydroxyisosapphire was measured in a peroxide inhibition test. The cumene was mixed with a radical forming agent in a closed vessel at 37 °C. To this end, 'mix 5 ml of isopropyl and 4 ml of benzene, and use i ml of 2,2 匕 azobis(2,4-dimethylvaleronitrile) (AMVN) in benzene. The 45 M solution initiated the reaction. The reaction mixture was sufficiently stirred and heated by a thermostat. As a result, a concentration of 3.6 mol/l of cumene and an AMVN concentration of 45 mmol/1 were produced for the reaction. With the aid of high performance liquid chromatography (HPLC), a 50 μΐ sample was removed from the vessel via a septum with a volume ratio of hexanone to isopropanol of 9 9 to 1 and a flow rate of 2 in per minute. The mobile phase of 1 is passed through a ruthenium tube column to determine the formation of cumene hydroperoxide. The pipe column has a size of 150 x 6.0 mm and a column packing particle size of 5 μηι. The cumene hydroperoxide and by-products formed by the reaction were detected at a wavelength of 254 nm and a retention time of 2.285 and 2.405 minutes, respectively, at 122883.doc -225 - 200816981. The area of the double peak is plotted against the reaction time in minutes to obtain a positive curve of the test system. The changed 3,3,-dihydroxyisoxanthene concentration was then further tested in the reaction mixture with reference to a calibration curve 'measured in minutes at varying concentrations of 3,3'-dihydroxyisoxanthene and other antioxidants. The delay in the formation of cumene hydroperoxide. In 2*1〇·4 m〇1/1, 4*ι〇·4 m_, mol/1w1 (r3 m〇1/1 of 3,3,_ di-isolated _

The reaction is delayed. For each of the measured antioxidant concentrations, the time until the reaction is completely inhibited is determined by calculating the corresponding axis intercept of the regression curve. The calculated inhibition time is then plotted against the respective antioxidant concentrations and the accessory regression is measured. The reference material curve, the antioxidant capacity of the peak antioxidant. The high gradient of the curve here indicates a high antioxidant effect.

The antioxidant action of 3,3.-di-iso-isosynthesis was determined in an oxygen partial pressure test. To a reaction system of 5 ml of cumene with 4 W of benzene and 1 ml of 2,2,-azobis(2,4-dimethylvaleronitrile) (AMVN) in 0.45 Μ solution in chlorobenzene Various antioxidants were supplied and subjected to an oxygen partial pressure of 15 Torr. The result, on 122883.doc -226- 200816981

The reaction produced a concentration of cumene of 3·6 mol/l and an AMVN concentration of 45 mmol/l plus a variable antioxidant concentration. During the course of the reaction, the partial pressure of oxygen was measured relative to the decrease in the reference vessel. The differential pressure gauge used is the instrument MKS

Baratron (Model 223B) and the absolute pressure gauge used was the instrument MKS Baratron (Model 122A). The value is read out in digital form by the instrument MKS PDR-D-1 type power digital readout. For better comparability, the measurement curve was normalized to an atmospheric pressure of 760 Torr and then measured for 50 and 70 minutes.

The gradient between the curves is multiplied by a factor of 665.7 (M*min) / (s * Torr) to convert the gradient to an oxidation rate (-d[02]/dt*l (T8 M/s). Low oxidation The rate here corresponds to a high antioxidant effect.

Antioxidant concentration oxidation rate/10_8 mol/l*s cryptoxanthin flavonoid astaxanthin dihydroxyisospinene 2.00* 10*3 32.19 19.71 11.94 1.99 ι.οο*ισ3 22.62 16.16 11.56 nd 4.00*104 13.60 8.26 8.86 3, 22 2.00* 10-4 16.44 18.67 11.68 2.27 4.00*10*' nmnmnm 5.92 4.00*10° 75.38 71.24 79.32 17.74 2.00*10° 83.88 80.13 87.88 77.39 nd = not measurable nm = unmeasured Example 36 Various carotenoids and phenols Comparison of the oxidation rate of the substance to 5 ml of cumene and 4 ml of chlorobenzene and 1 ml of 2,2'-azobis(2,4-dioxyl valeronitrile) (AMVN) in chlorobenzene The reaction system of the 0·45 hydrazine solution was supplied with various antioxidants and subjected to an oxygen partial pressure of 150 Torr. As a result, a concentration of cumene of 3·6 mol/l and an AMVN concentration of 45 mmol/l were obtained for the reaction. 122883.doc -227 - 200816981

The concentration is 2.00*1 (Γ5 or 4.00*10·5 of antioxidant. During the reaction, the oxygen partial pressure is measured relative to the reference container. The differential pressure gauge used is the instrument MKS Baratron (type 223B) And the absolute pressure gauge used is the instrument MKS Baratron (Model 122A). The value is read in digital form by the instrument MKS PDR-D-1 type power digital reader. For better comparability, the amount The curve was normalized to a standard pressure of 760 Torr and then a curve gradient between 50 and 70 minutes was determined and multiplied by a factor of 665_7 (M*min) / (s* Torr) to convert the gradient to an oxidation rate (-d [02]/dt* 1 (Γ8 M/s). The low oxidation rate corresponds here to a high antioxidant effect. The abbreviation BHT in the table is 4-methyl-2,6-di-t-butylphenol. The abbreviation BHT-carotenoid is 3,3'-dihydroxy-2,2\4,4'-tetra-tert-butylisoxanthene. The abbreviation DHIR in the table is 3,3'-dihydroxyiso Spiroene. Abbreviation in the table DB-BHT·Carotenoid is dibenzylhydrazine-BHT-carotenoid. Oxidation rate / 10'8 mol/l*s oxidation rate / 10*8 mol/l*s antioxidant Concentration 2.00 *10' :) 4.00*10'&quot; Antioxidant α-Tocopherol 101.7 99.8 Resveratrol 87.6 69.8 ΒΗΤ 108.9 100.2 ΒΗΤ-Carotenoid 93.1 30.8 DHIR 77.4 17.7 DB-BHT-Carotenoid 98.0 93.7 Astaxanthin 102.4 96.2 Spot Chelated yellow 103.0 96.6 cryptoxanthin 96.0 86.0 zeaxanthin 96.9 81.2 122883.doc -228 -

Claims (1)

200816981 • Patent application scope: a hetero-saponene compound of the general formula (I), an antioxidant comprising at least one substance (1) Wherein R^H or a protecting group which is easily cleaved, 鹣 R to R are independently the same or different from each other. to. alkyl. 2) The antioxidant according to claim 1, j: white s t 4 comprising at least one isosynthesis methyl group (3,3 fluorene-dihydroxyisoxanthene) 3. (I), wherein RkH and R2 are An antioxidant comprising at least an olefinic compound (I) and an iso-saponene _3,3, _ a species such as the sponge of the claim 1 or 2 '醌(II) Or 2,2,,4,4,-tetra-tridecylisoxanthene 3,3,·dioxin(III) 122883.doc 200816981 Tributylisoxyl (IV) Or 3,3'-dihydroxy-2,2',4,4'tetra- or a mixture thereof. 4. A mixture (Ml) comprising at least one of the different seas/methene compounds (1) and isosporenes, 3,3, _ bis (π) or 2, 2, 4, 4 , _ tetra-tert-butyl iso-saponene-3,3,-dioxime (hydrazine) or a mixture thereof. 5. A mixture (M2) comprising 3,3,-dihydroxy-2,2,4,4,-tetra-tert-butylisoxenene (IV) and at least one of the claims or Isoprene compound (I) or a mixture according to claim 4, wherein the preparation comprises at least one isospinene compound (I) or iso-saponene_3 as claimed in claim 2 or 2, 3, _ 醌 (11) or 2, 2, 4, 4, _ tetra _ tert-butyl • iso-sulphide bis (III) or 3, 3 匕 dihydroxy-2, 2 丨, 4, 4 ,-tetra-tert-butylisoxylene (IV) (compound v) or a mixture thereof. 7. A dermatological skin care product, pharmaceutical, food or animal feed comprising at least one compound (V) or a system thereof Prepared using at least one formulation as claimed in claim 6. 8. 11 or a liquid or mixture thereof comprising at least one seed (V). 9. A coloring agent comprising isosporene-3,3匕Diterpenes (1][) or 2,2,,4, anthracene-tert-butylisoxylene_3,3,_dioxin (ΠΙ) or W匕dihydroxy, 122883.doc 200816981 2,2' , 4,4'-tetra-t-butylisoxenene (IV) or mixture (mi) Ge (M2) 〇10· a coloring agent comprising at least one compound (V) in the form of ruthenium or J aggregates ·11. A dermatological skin care product, pharmaceutical, food or animal feed comprising at least one such as claim 9 Or a coloring agent of 12. A solid or a liquid or a mixture thereof comprising at least one coloring agent as claimed in claim 9 or 10. 13 - a vesicle containing at least one compound (ν). A dermatological skin care product, a pharmaceutical product, a food or animal feed comprising the vesicles of claim 13. A solid or liquid or a mixture thereof comprising the vesicles of claim 3. a carotenoid formulation comprising at least one compound (ν). A formulation comprising at least one carotenoid formulation of claim 16 or a system thereof using at least one formulation as claimed in claim 6 18. A dermatological skin care product, pharmaceutical, food or animal feed comprising at least one carotenoid formulation as claimed in claim 16 or a system thereof, at least one of which is as claimed in claim 6 Preparation of a 19. A gelatin capsule comprising at least one carotenoid formulation of claim 16 or a system thereof using at least one carotenoid formulation as claimed in claim 16. 20 - an antioxidant, a mixture Ml) or (M2), preparations, colorants, vesicles, carotenoid formulations, dermatological skin care products, pharmaceuticals, 122883.doc 200816981 food or animal feed, gelatin capsules or other solid or liquid or mixtures thereof, It comprises at least one compound (v) in micronized form. An antioxidant, a mixture (M1) or (M2), a preparation, a coloring agent, a vesicle, a carotenoid formulation, a dermatological skin care product, a pharmaceutical product, according to at least one of claims 1 to 19. , a method of food or animal feed, gelatin capsules or other solid or liquid or mixtures thereof, wherein during preparation thereof, at least one of at least one of claims i to 6, 9, 1 〇, 13, 16 or 17 is used. Compound (7), anti-oxidation mixture (M" or (M2), formulation, colorant, vesicles or carotenoid formulations 0 22. - species or even species (4) seeking to 6, 9, 1 (), 13, 16 or 17 Compound (V), anti-deuteration agent, mixture _) or (), "colorant, vesicle or carotenoid formulation for the preparation of anti-gas diterpenes, compounds, preparations: colorants, micro Liposome, carotenoid == skin medicine skin...medicine, food or animal feed, gelatin gum other solid or liquid or a mixture thereof. ~ capsule or 122883.doc 200816981 VII, designated representative map: ( a) The representative representative of the case is: (none) (2) The symbolic symbol of the representative figure is simple: 8. If there is a chemical formula in this case, please disclose the chemical formula that best shows the characteristics of the invention·· 122883.doc