WO2008009675A2 - Uses of 3,3'-dihydroxyisorenieratene and related carotinoids - Google Patents

Abstract

The invention relates to antioxidants, mixtures, preparations, dyes, vesicles, carotinoid formulations, dermocosmetic products, pharmaceuticals, food and fodder, and other solids or liquids or the mixtures thereof, which contain 3,3'-dihydroxyisorenieratene, isorenieratene-3,3'-diquinone, 2,2',4,4'-tetra-tert-butylisorenieratene-3,3'-diquinone, 3,3'-dihydroxy-2,2',4,4'-tetra-tert-butylisorenieratene or related isorenieratene compounds, or have been produced using said compounds, or by means of a method which uses said compounds.

Description

 Uses of 3,3'-dihydroxyisorenieratin and related carotenoids

The present invention relates to antioxidants, mixtures, preparations, colorants, vesicles, carotenoid formulations, dermocosmetics, pharmaceuticals, foodstuffs and animal feeds as well as other solids or liquids or mixtures thereof which are 3,3'-

Dihydroxyisorenieratin, isorenieratin-3,3'-dichinone, 2,2 ', 4,4'-tetra-tert-butylisorenieratin-3,3'-dichinone, 3,3'-dihydroxy-2,2', 4,4 ' or tetra-tert-butylisorenieratin or related Isorenieratin- compounds using these compounds or with a method containing the use of these compounds were prepared. Preferred embodiments are given in the claims and the description.

Antioxidants, mixtures, preparations, colorants, vesicles, carotenoid formulations, dermocosmetics, pharmaceuticals, food and feed as well as other solids or liquids or mixtures thereof are complex mixtures of substances and show a high variability. It is therefore to be understood that the features of the subject invention described above and those yet to be explained below can be used not only in the specific combination specified in each case but also in other combinations without departing from the scope of the invention. In particular, preferred embodiments can be combined with one another.

Carotenoids and other natural products have long been used as dyes and antioxidants as well as in dermocosmetics, food and feed. In fact, many of the yellow to red colored carotenoids occur as natural products in feed and feed feedstock.

Thus, carotenoids in colorants and carotenoid formulations can be used for human consumption. The document DE 198 02 134 A1 describes colorants from carotenoid aggregates. The document DE 198 38 636 A1 Carotenoid formulations from the combination of the carotenoids β-carotene, lycopene and lutein.

It is understood that wide application areas make high demands on the corresponding carotenoids, which often can not fulfill these to the desired extent. Especially properties such as availability, stability, solubility and antioxidant activity of naturally occurring carotenoids are often not sufficient to make them technically usable.

A previously used antioxidant carotenoid is astaxanthin. It is widely used as a dye with antioxidant effect in food and feed. Furthermore, research results are available which show the positive effects of astaxanthin on, for example, the immune system, kidneys, eyes, nerves, veins as well as diabetes, cancer, hypertension and a general anti-inflammatory effect (Ghazi Hussein et al., Astaxanthin, a Carotenoid with Potential in Human Health and Nutrition, J. Nat., Prod., 2006, 69, 443-339). Due to their antioxidant properties, astaxanthin derivatives can be used prophylactically and / or therapeutically for many diseases that are triggered or promoted by oxidative processes in, on or on the body. In order to improve the solubility of astaxanthin in an aqueous medium, derivatives of astaxanthin are generally used for this purpose. Here, the astaxanthin is derivatized with easily cleavable protecting groups. Corresponding applications and derivatives or readily cleavable protective groups are described in US 2005/0065096 A1 and in Gross J., et al., Cardioprotection and myocardial salvage by a sodium disuccinate astaxanthin derivative (Cardax ™), Life Sciences 75, 2004, 215 224 described.

According to a scientific publication, the synthetic carotenoid 3,3'-dihydroxy-2,2 ', 4,4'-tetra-tert-butylisorenieratin (BHT carotenoid) has good antioxidant properties (Beutner, S. et al., Modified flavonoids as strong photoprotecting UV absorbers and antioxidants, Advances in Color Science and Technology, 2002, 5, 103-112).

A technical use of this compound, in particular in dermocosmetics, pharmaceuticals, food and feed and in particular in higher concentration has not been disclosed.

One of the objects of the present invention has been to find carotenoids which are versatile and widely applicable and readily available for technical applications. On the one hand, the task was to provide carotinoids which are well tolerated by humans and animals, which are not only used in dermocosmetics, food and animal feed and protect them against oxidative influences, but also through their superior antioxidant activity and good health properties as far as possible also the state of health of humans and animals by their use in dermocosmetics, food and feed prophylactically or therapeutically positively influence. On the other hand, the object was to provide carotenoids which can be used with good antioxidant activity in low concentrations and thus offer the possibility of an undesirable color effect, especially for applications in the dermocosmetic or pharmaceutical sector, in food or feed or in Mixtures, preparations, vesicles, colorants or carotenoid formulations. On the other hand, on the basis of these carotenoids, a further aspect of the task was to achieve attractive color effects precisely by means of this color effect and to make this possible, in particular with good tolerability for humans and animals alike. A further object was to provide carotenoids which, alone or in mixtures with other carotenoids, form aggregates with color-stabilizing or vesicle- or lipid-phase-stabilizing action and thus can advantageously be used in colorants, vesicles or other lipid phases.

3,3'-dihydroxyisorenieratin, isorenieratin-3,3'-dichinone, 2,2 ', 4,4'-tetra-tert-butylisorenieratin-3,3'-dichinone, 3,3'-dihydroxy-2,2' , 4,4'-tetra-tert-butylisorenieratin or related isorenieratin compounds, in particular 3,3'-dihydroxyisorenieratin, solve the stated problems. Because of their surprisingly good and other carotenoids superior antioxidant properties.

The resulting articles of the invention will be described in the course of the disclosure of the invention.

definitions

Isorenieratin compounds or compounds (I) are compounds of the general

Formula (I)

wherein

R ¹ = H or an easily cleavable protecting group or its physiologically acceptable salts,

R ² to R ^{4 are} independently the same or different and may be a Ci to C3 alkyl group.

Easily cleavable protecting groups are linked, for example, via ether compounds or ester compounds and are preferably tocopherol, resveratrol or alkyl or alkene carboxylic acids, such as oleic acid, palmitate, ascorbate, succinate, acetylsalicylate or amino acids, such as lysine. Further easily cleavable protecting groups can be taken from US 2005/0065096 A1.

3,3'-Dihydroxyisorenieratin is a compound of formula (Ia):

Isorenieratin-3,3'-dichinone or compound (II) is a compound of the formula (II):

2,2 ', 4,4'-tetra-tert-butylisorenieratin-3,3'-dichinone or BHT-carotenoid-quinone or compound is a compound of the formula

3,3'-Dihydroxy-2,2 ', 4,4'-tetra-tert-butylisorenieratin or BHT carotenoid or compound (IV) is a compound of formula (IV):

Among compounds (V) in the following Isorenieratin compounds according to the invention or compounds (I) or isorenieratin-3,3'-dichinone or compound (II) or

2,2 ', 4,4'-tetra-tert-butylisorenieratin-3,3'-dichinone or compound (III) or

3,3'-dihydroxy-2,2 ', 4,4'-tetra-tert-butylisorenieratin or compound (IV) are understood. carotenoids

Carotenoids are tetraterpenes in which one or two ionon rings are linked by a carbon chain having 9 double bonds, and which may be of microbial, plant or animal origin or have been prepared in a chemical synthesis. Carotenoids are also understood to mean the oxygen-containing xanthophylls. Examples include: alpha, beta, gamma-carotenes, bixin, norbixin, capsanthin, capsorubin, lycopene, beta-apo-8'-carotenal, beta-apo-8'-carotenoic acid ethyl ester, xanthophylls, lutein, crypto xanthine, rubixanthin, violaxanthin, rhodoxanthin or canthaxanthin. The above compounds (V) fall into the class of carotenoids. If the abovementioned compounds (V) in addition to other carotenoids z. B. present as a mixture component, these carotenoids are merely other carotenoids, which do not include the above compounds (V).

Dermocosmetics or dermocosmetic "dermocosmetics" or "dermocosmetics" describes skin-cosmetic, hair-cosmetic, dermatological or hygienic agents and / or formulations for topical application to skin or hair, suitable (i) for the prevention of damage to human skin and / or human hair, ( (ii) to treat damage to human skin and / or human hair that has already occurred, (iii) to care for human skin and / or human hair, (iv) to improve skin feel (sensory properties). Explicitly included are perfumes and decorative cosmetics, for example kohlstif- te, mascara, eye shadows, tinted day creams, powders, concealers, rouge, lipsticks, lip pencils, make-up, nail polish or glamor gel. Also included are skin care compositions in which the pharmaceutically dermatological application is achieved, taking into account cosmetic aspects. Such dermocosmetics are used for the support, prevention and treatment of skin diseases and can develop a biological effect in addition to the cosmetic effect. The dermocosmetics according to the invention are particularly preferably dermocosmetics for protecting the skin from damage by sunlight, in particular by UV-B (280 to 320 nm) and UV-A radiation (> 320 nm). Very particular preference is given to dermocosmetics containing the lipophilic vitamins A, D, E, K and their derivatives, preferably vitamin A or .beta.-carotene. Dermocosmetics contain in a cosmetically acceptable medium suitable auxiliaries and additives, which are chosen with regard to the specific field of application. Such auxiliaries and additives are familiar to the expert and can, for. B. Manuals of cosmetics, such as Schrader, bases and formulations of cosmetics, Hüthig Verlag,

Heidelberg, 1989, ISBN 3-7785-1491-1, or Umbach, cosmetics: development, production and application of cosmetic products, 2nd extended edition, 1995, Georg Thieme Verlag, ISBN 3 13 712 602 9, are taken.

Dermocosmetics suitable for protecting human skin or hair against UV radiation contain one or more organic and / or inorganic light stabilizers or UV filters in combination with one or more of the following substances: stamping agents: emulsifiers, surfactants, preservatives, perfume oils, thickeners, hair polymers, hair and skin conditioners, graft polymers, water-soluble or dispersible silicone-containing polymers, gelling agents, conditioners, tanning agents, tanning agents, dyes, pigments, bodying agents, moisturizers, moisturizers, collagen, protein hydrolysates, lipids , and / or antioxidants.

"Dermocosmetic agents" or "dermocosmetically active agents" in the context of the present invention are the active ingredients present in dermocosmetics which are (i) for the prevention of damage to human skin and / or human hair, (ii) for the treatment of damage already occurred human skin and / or human hair; (iii) human skin and / or human hair care; (iv) skin feel enhancement (sensory properties); and (iv) decorative beautification or enhancement of the appearance of human skin and / or or human hair. Such agents are for. B. selected from the group of natural or synthetic polymers, pigments, humectants, oils, waxes, proteins, enzymes, minerals, vitamins, sunscreens, fragrances, Peroxydzersetzer and preservatives and pharmaceutical agents used to support, prevent and treat skin diseases and have a healing, lesions preventive, regenerating or improving the general condition of the skin biological effect. Suitable cosmetically and / or dermocosmetically active agents are, for. Coloring agents, skin and hair pigmentation agents, tinting agents, suntanning agents, bleaching agents, keratin-hardening substances, antimicrobial agents, light filter active substances, repellent active substances, hyperemic substances, keratolytic and keratoplastic substances, antiperspirant active ingredients, antiphlogistics, keratinizing substances, antioxidant or as radical scavengers active ingredients, skin moisturizing or moisturizing substances, moisturizing agents, anti-erythematous or anti-allergic active ingredients, branched fatty acids such as 18-Methyleicosansäure, and mixtures thereof.

As further dermocosmetic agents can be used for example: acetylsalicylic acid, atropine, azulene, hydrocortisone and its derivatives, eg. As hydrocortisone 17-valerate, vitamins of the B and D series, especially vitamin Bi, vitamin B12, vitamin D, vitamin A or its derivatives such as retinyl palmitate, vitamin E or its derivatives such. As tocopheryl acetic, vitamin C and its derivatives such. As ascorbyl glucoside but also niacinamide, panthenol, bisabolol, polydocanol, unsaturated fatty acids such. As the essential fatty acids (commonly referred to as vitamin F), in particular γ-linolenic acid, oleic acid, eicosapentaenoic acid, docosahexaenoic acid and its derivatives, chloramphenicol, caffeine, prostaglandins, thymol, camphor, squalene, extracts or other products of plant and animal origin, z. B. evening primrose oil, borage oil or blackcurrant seed oil, fish oils, cod liver oil but also ceramides and ceramide-like compounds, frankincense extract, water purée extract, licorice extract, witch hazel, anti-dandruff active ingredients (eg, selenium disulfide, zinc pyrithione, piroctone, olamine, climbazole, octopirox, polydocanol and their combinatines ), Complexing agents such. Those of γ-oryzanol and calcium salts such as calcium panthotenate, calcium chloride, calcium acetate. It is also advantageous, the dermocosmetic agents from the group of lubricating Select substances, for example Purcellinöl, Eucerit ^® and Neocerit ^® . The active ingredient (s) are furthermore particularly advantageously selected from the group of NO synthase inhibitors, in particular when the preparations according to the invention are used for the treatment and prophylaxis of the symptoms of intrinsic and / or extrinsic skin aging and for the treatment and prophylaxis of the harmful effects of ultraviolet radiation on the skin and the Hair should serve. Preferred NO synthase inhibitor is nitroarginine. Also advantageous are the active ingredients selected from the group comprising catechins and bile acid esters of catechins and aqueous or organic extracts of plants or plant parts which have a content of catechins or bile acid esters of catechins. Also advantageous are their typical ingredients (eg polyphenols or catechins, caffeine, vitamins, sugars, minerals, amino acids, lipids). Catechins represent a group of compounds which are to be regarded as hydrogenated flavones or anthocyanidins and derivatives of "catechin" (catechol, 3,3 ', 4', 5,7-flavanpentaol, 2- (3,4-dihydroxyphenyl) -chroman Also, epicatechin ((2R, 3R) -3,3 ', 4', 5,7-flavanpentaol) is an advantageous active ingredient in the context of the present invention Extracts containing catechins, in particular extracts of green tea, such as extracts from leaves of the plants of the species Camellia spec, in particular the teas Camellia sinenis, C. assamica, C. taliensis or C. inawadiensis and crosses Preferred active substances are also polyphenols or catechins from the group (-) - catechin, (+) - catechin, (-) - catechin gallate, (-) - gallocatechin gallate, (+) - epicatechin, (-) Epicatechin, (-) - epicatechin gallate, (-) - epigallocatechin, (-) - epigallocatechin gallate.

"Cosmetically acceptable medium" is to be understood broadly and means substances suitable for the production of dermocosmetics and mixtures thereof If the abovementioned compounds (V) are used during the production of dermocosmetics or are contained in dermocosmetics, cosmetically acceptable media are to be used only substances are understood which do not comprise the abovementioned compounds (V).

"Substances that are cosmetically compatible" are all substances that generally do not cause any irritation or damage when they come into contact with human or animal skin tissue or hair, and are generally incompatible with other substances These substances are familiar to the expert and may, for example, manuals of cosmetics, for example Schrader, bases and formulations of cosmetics, Hüthig Verlag, Heidelberg, 1989, ISBN Although compounds (V) generally do not cause irritation or damage on contact with human or animal dermal tissue or hair, compounds (V) are to be distinguished from the term cosmetic in the following compatible substances. flavones

Flavones and their derivatives (often collectively referred to as "flavones") are also advantageous dermo-cosmetic active substances in the context of the present invention Flavones are normally present in glycosylated form in nature.

where Z ¹ to Z ⁹ , independently of one another, are selected from the group consisting of H, OH, alkoxy and hydroxyalkoxy, where the alkoxy or hydroxyalkoxy groups may be branched and unbranched and have from 1 to 18 carbon atoms. Z ⁶ can be glycosylated, the corresponding radical being selected from the group of mono- and oligoglycoside radicals.

Some of the more important flavones, which can also be used with preference in formulations according to the invention, have one or more substituents Z, for example one to six substituents Z, where Z can in particular be an OH group, as listed in Table 1 below.

Table 1: Flavones

In addition, the dermocosmetic agents (one or more compounds) can also be chosen very advantageous from the group of hydrophilic active ingredients, in particular from the following group: α-hydroxy acids such as lactic acid or salicylic acid or salts thereof such. As Na-lactate, Ca-lactate, TEA-lactate, urea, allantoin, serine, sorbitol, glycerol, milk proteins, panthenol, chitosan.

Artificial skin tanning dermocosmetic agents that are suitable for tanning the skin without natural or artificial irradiation with UV rays, z. Dihydroxyacetone, alloxan and walnut shell extract. Suitable keratin-hardening substances are usually dermocosmetische active ingredients, as they are also used in antiperspirants, such as. For example, potassium aluminum sulfate, aluminum hydroxychloride, aluminum lactate.

peroxide decomposers

As Peroxidzersetzer substances from different substance classes can be used. It goes without saying that substances are used for human and animal applications only substances that usually have no adverse effect on health in the concentrations used. Substances suitable as peroxide decomposers may be sulfur-containing substances in which the sulfur is present in an oxidation state of less than +6. Phosphorus-containing compounds in which the phosphorus is present in an oxidation state of less than +5, as well as aromatic amines into consideration. The compounds containing sulfur and phosphorus may be of organic or inorganic nature, with substances of an organic nature being preferred. Whether certain compounds are suitable as Peroxidzersetzer, recognized in vitro, for example, that at room temperature, dissolved in a molar concentration of 0.05 m / l in a polar or non-polar solvent within 10 minutes, the peroxide or hydroperoxide concentration reduce by at least 20%, preferably 50% and in particular 90%. Substance classes containing peroxide decomposers are, for example: mercaptans, dialkyl, diaryl or arylalkyl sulfides, dialkyl disulfides, dialkyl sulfoxides, sulfinic acids and their esters and amides, sulfenic acid esters or amides, thioesters, thioamides, thioureas, thiocarbonyl compounds, thioacetals or ketals also in cyclic form. Pyridine-2-thiol-3-carboxylic acid, 2-methoxy-pyrimidinol-carboxylic acids, 2-methoxy-pyridinecarboxylic acids, 2-dimethylamino-pyrimidinolcarboxylic acids, 2-dimethylaminopyridinecarboxylic acids. Further examples are described in WO0207698 and WO03059312. Radical decomposer or radical scavenger:

Radical decomposers or radical scavengers are substances that can disrupt radical reaction chains by reacting with radicals and neutralizing them. Such radicals are for example hydroxy radicals, radical photoproducts or singlet oxygen. Substances which can be used as radical decomposers or free-radical scavengers are described, for example, in DE 19739349 or in WO2005 / 042828.

antioxidants

Antioxidants are substances that can protect other substances from oxidative reactions. As antioxidants, for example, amino acids (eg, glycine, histidine, tyrosine, tryptophan) and their derivatives, imidazoles (eg, urocanic acid) and their derivatives, peptides such as D, L-carnosine, D-carnosine, L-carnosine, and their derivatives (eg anserine), carotenoids, carotenes (eg α-carotene, β-carotene, lycopene) and their derivatives, chlorogenic acid and its derivatives, lipoic acid and derivatives thereof (eg dihydrolipoic acid), aurothioglucose , Propylthiouracil and other thiols (eg thioredoxin, glutathione, cysteine, cystine, cystamine and their glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl, oleyl , y-linoleyl, cholesteryl and glyceryl esters) and their salts, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and derivatives thereof (esters, ethers, peptides, lipids, nucleotides, nucleosides and salts) and sulfoximine compounds (eg buthionine sulfoximines, Homocysteine sulphoximine, buthione sulphones, penta, hexa, heptathioni nsulfoximin) in very low tolerated dosages (eg. Pmol to μmol / kg), furthermore (metal) chelators (for example α-hydroxyfatty acids, palmitic acid, phytic acid, lactoferrin), α-hydroxy acids (for example citric acid, lactic acid, malic acid), humic acid, Bile acid, bile extracts, bilirubin, biliverdin, ethylenedinitrilotetraacetic acid (EDTA), ethylenebis (oxyethylenenitrilo) tetraacetic acid (EGTA) and its derivatives, unsaturated fatty acids and their derivatives (eg γ-linolenic acid, linoleic acid, oleic acid), folic acid and their derivatives Derivatives, furfurylidene sorbitol and its derivatives, ubiquinone and ubiquinol and their derivatives, vitamin C and derivatives (eg ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (eg vitamin E acetate), vitamin A and derivatives (vitamin A palmitate) and Koniferylbenzoat of Benzoeharzes, rutinic acid and derivatives thereof, α-glycosyl rutin, ferulic acid, furfurylidenglucitol, carnosine, butylhydroxytoluene, butylated hydroxyanisole, Nordihydroguajakharzsäure, Nordihydroguajarets acid, trihydroxybuthyrrophenone, uric acid and its derivatives, mannose and its derivatives, zinc and its derivatives, selenium and its derivatives (eg. Selenium methionine), stilbenes and their derivatives (eg stilbene oxide, trans-stilbene oxide). The compounds (V) can be used as antioxidants. When the above-mentioned compounds (V) are used besides antioxidants, these antioxidants are merely meant to mean further antioxidants which do not include the above-mentioned compounds (V). Antimicrobial agents

Antimicrobial agents are used to destroy microorganisms or to inhibit their growth and thus can serve both as a preservative and as a deodorizing substance, which reduces the formation or intensity of body odor. As antimicrobial agents and preservatives, for example, conventional, known in the art antimicrobial agents and preservatives, such as p-hydroxybenzoic acid, imidazolidinyl urea, formaldehyde, sorbic acid, benzoic acid, salicylic acid, etc. Such deodorizing substances are, for. As zinc ricinoleate, triclosan, Undecylensäurealkylolamide, citric acid triethyl ester, chlorhexidine can be used.

Further suitable antimicrobial agents are:

Table 2: suitable antimicrobial agents. The E numbers listed in the above table are the common names in Directive 95/2 / EEC.

Other antimicrobial agents and preservatives are also suitable, in particular, they are suitable to be incorporated into the dermocosmetics and pharmaceuticals according to the invention. Advantageous substances are, for example, 2,4,4'-trichloro-2'-hydroxydiphenyl ether (Irgasan), 1, 6-di- (4-chlorphenylbiguanido) hexane (chlorhexidine), 3,4,4'-trichlorocarbanilide, quaternary ammonium compounds , Clove oil, mint oil, thyme oil, triethyl citrate, farnesol (3,7,11-trimethyl-2,6,10-dodecatrien-1-ol) as well as those disclosed in the patent publications DE-37 40 186, DE-39 38 140, DE-42 04 321, DE-42 29 707, DE-43 09 372, DE-44 11 664, DE-195 41 967, DE-195 43 695, DE-195 43 696, DE-195 47 160, DE-196 02 108, DE-196 02 110, DE-196 02 11 1, DE-196 31 003, DE-196 31 004 and DE-196 34 019 and the patent DE-42 29 737, DE-42 37 081, DE-43 24 219, DE-44 29 467, DE-44 23 410 and DE-195 16 705 described active ingredients or drug combinations. Also, sodium bicarbonate is advantageous to use. Likewise, microbial polypeptides can be used. Other are: dibromodicyanobutane (2-bromo-2-bromomethyl-glutarodinit. Nl), 3-iodo-2-propynyl butyl carbamate, 2-bromo-2-nitro-propane-1,3-diol, imidazolidinyl urea, 5-chloro-2 methyl-4-isothiazolin-3-one, 2-chloroacetamide, benzalkonium chloride and benzyl alcohol suitable. Further, phenylhydroxy are alkyl ethers, in particular the known under the name phenoxyethanol compound is suitable because of their bactericidal and fungicidal effects on a number of microorganisms as antimicrobial agent and as a preservative.

perfume oils

Perfume oils are usually mixtures of natural and synthetic fragrances, which are used for example in perfumes. Natural sources of substances which are suitable as fragrances are extracts of flowers, for example of lily, lavender, rose, jasmine, neroli, ylang-ylang, stems and leaves, for example of geranium, patchouli, petitgrain, fruits, such as anise , Coriander, caraway, juniper, fruit peel, for example of bergamot, lemon, orange, roots, such as mace, angelica, celery, cardamom, costus, iris, calmus, wood, such as pine, sandal, guaiac, cedar Rosewood, herbs and grasses, for example tarragon, lemongrass, sage, thyme, needles and twigs, for example of spruce, fir, pine, pines, resins and balsams, such as galbanum, elemi, benzoin, myrrh, olibanum, opoponax. Furthermore, animal raw materials come into consideration, such as civet and Castoreum. Typical synthetic substances which are used as fragrances are products of the type of esters, ethers, aldehydes, ketones, alcohols and hydrocarbons. Fragrance compounds of the ester type are, for example, benzyl acetate, phenoxyethyl isobutyrate, 4-tert-butylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbinyl acetate, phenylethyl acetate, linalyl benzoate, benzyl formate, ethylmethylphenylglycinate, allylcyclohexylpropionate, styrallyl propionate and benzylsalicylate. The ethers include, for example, benzyl ethyl ether, to the aldehydes, for example, the alkanals having 8 to 18 carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamen aldehyde, hydroxycitronellal, lilial and bourgeonate, to the ketones, for example, the Jonone, cc-lsomethylionen and Methylcedrylketon to the alcohols include aethethol, citronellol, eugenol, isoeugenol, geraniol, linalool, phenylethyl alcohol and terioneol; the hydrocarbons mainly include the terpenes and balsams. Preferred are However, mixtures of various substances used as fragrances, which together produce an appealing scent. Essential oils of lower volatility, which are mostly used as aroma components, are suitable as perfume oils or fragrances, for example sage oil, camomile oil, clove oil, lemon balm oil, mint oil, cinnamon leaf oil, lime blossom oil, safflower oil, vetiver oil, oliban oil, galbanum oil, labolanum oil and lavandin oil. Preferably, bergamot oil, dihydromyrcenol, lilial, lyral, citronellol, phenylethyl alcohol, α- hexylcinnamaldehyde, geraniol, benzyl acetone, cyclamen aldehyde, linalool, Boisambrene ^® Forte, Ambroxan, indole, hedione, Sandelice, lemon oil, mandarin oil, orange oil, allyl amyl glycolate, Cyclovertal, lavandin, muscatel sage oil, beta-damascone, geranium oil bourbon, cyclohexyl salicylate, Vertofix ^{® ®} Coeur, Iso-e-Super, Fixolide ^® NP, Evernyl, Iraldein gamma, Phenylessigsäu- acid, geranyl acetate, benzyl acetate, rose oxide, romillat, irotyl and floramat alone or used in mixtures.

flavors

Flavors are mixtures of odorous substances or flavorings (flavoring substances) which are especially intended to give food a special smell or taste. Flavors can contain substances that can also be used as perfume oils or fragrances. Flavors can contain, in addition to a variety of flavors, other substances, such as solvents, carriers, preservatives and antioxidants. Flavorings can consist of natural flavors, nature-identical flavors, artificial flavors, aroma extracts, reaction aromas and smoke flavors. Preferred flavorings are natural flavorings, nature-identical flavorings and artificial flavorings. Flavorings may be biochemically synthesized or fully synthetic and may be free or bound as glycoside (bound flavors). Substances that are suitable as flavorings usually fall into the group of alcohols, aldehydes u. Ketones, esters, lactones, sulfides and the like Heterocycles, such as furan derivatives, pyrazines, thiazoles or thiophenes, terpenes, sesquiterpenes, thiols, sulfides, di-, tri-, tetra-u. Pentasulfides, trithiolanes, thioesters, alkenals, glucosinolates or isothiocyanates. For example, α-ionone, β-ionone, γ-ionone, 2-acetyl-1-pyrroline, (2E, 4Z) -decadienoic acid ester, bis (2-methyl-3-furyl) disulphide, Methyl-3- (methylthio) furan, (+) - nootkatone, (+) - (S) -carvone, (+) - (R) -p-menth-1-ene-8-thiol, cital, neral, geranial Citronellal, vanillin biacetyl, maltol, 2-methoxy-3-isobutylpyrazine, 4- (4-hydroxyphenyl) -2-butanone, butyric acid, methyl ketones, ethyl acetate, acetoin, butane-2,3-dione, γ-dexalactone, γ Lactones 3-ethyl-5-methyl-1, 2,4-trithiolane, 1,2-dithiolane-4-carboxylic acid, 1, 2-dithiolane-4-carboxylic acid methyl ester, 1, 2-dithiacyclopentene, 2-propenoic acid acid methyl ester, 3- (methylthio) thiopropionic acid S-methyl ester, 1-penten-3-one, 1-nitro-2-phenylethane 2-alkyl-3-methoxypyrazine, (2-isopropylpyrazine, 2-isobutylpyrazine, 2 -sec-butylpyrazine, (E) -2-nonenal, (E, Z) -2,6-nonadienal, (E, E) -2,4-decadienal, hexan-1-ol and (Z) - 3-hexen-1-ol, (E, Z) -2,6-nonadienal, (E) - and (Z) -2-nonenal, (Z) -1, 5-octadien-3-one 2-iso propyl-3-methoxypyrazine, 2,5-dimethylpyrazine, 2-ethyl-3,6-dimethylpyrazine, (E) -2-nonenal, (E) -2-decenal, (E, E) -2,4-decadienal, 2-sec-butyl-3-methoxypyrazine, (E, Z) -2,6-nonadienal, (E, E) -2,4- Decadienal, 2-alkyl-3-methoxy-2-ylazine, 3-ethyl-5-methyl-1, 2,4-trithiolane, 1, 2-dithiolane-4-carboxylic acid 1, 2-dithiacyclopentene, 2-acetylthiazole, geosmin, hexanal, ( Z) -3-hexenal, (E) -2-hexenal, hexanal, β-damascenone, 1-penten-3-one, 3-methylbutanal, 2-isobutylthiazole, dimethylsulfide, 1-nitro-2-phenylethane, eugenol , Methional, 3-methylbutyric acid (E, Z) -2,6-nonadienal, (-) - (R) -carvone, (-) - (R) -1-octen-3-ol, (-) - (R ) -1-octen-3-ol, benzaldehyde, p-anisaldehyde,

2-aminobenzaldehyde, methyl anthranilate, 1, 3-dimethoxybenzene, coumarin, herniarine, limettin.

Oils, fats and waxes

As oils, fats and waxes may be used, for example: hydrocarbon oils such as paraffin oil, purcellin oil, perhydrosqualene and solutions of microcrystalline waxes in these oils; animal or vegetable oils, such as sweet almond oil, avocado oil, Calophylumöl, lanolin and derivatives thereof, castor oil, sesame oil, olive oil, jojoba oil, karite oil, hoplostethus oil, mineral oils whose distillation begins under atmospheric pressure at about 250 ⁰ C and their distillation endpoint at 410 ⁰ C, such as vaseline oil, esters of saturated or unsaturated fatty acids such as alkyl myristates such as i-propyl, butyl or Cetylmyristat, hexadecyl, ethyl or i-propyl palmitate, octanoic or Decansäuretriglyceride and Cetylricinoleat or other oil-soluble silicone oils such as dimethylpolysiloxane, methylphenylpolysiloxane and the silicone glycol copolymer, fatty acids and fatty alcohols, fatty ketones, fatty aldehydes, fatty ethers and fatty carbonates, for example laurone and distearyl ether or fatty acids such as stearic acid, hydroxystearic acid or behenic acid, ring-opening products of olefin epoxides with C 12 -C 22 carbon atoms Fatty alcohols with C12-C22 Carbon atoms and / or polyols having C2-C15 carbon atoms and C2-C10 hydroxyl groups and mixtures thereof. Examples of waxes which may be used are: carnauba wax, candililla wax, beeswax, microcrystalline wax, ozokerite wax and Ca, Mg and Al oleates, myristates, linoleates and stearates.

Oils, fats and waxes are furthermore advantageously selected from the group of the lecithins and the fatty acid triglycerides, namely the triglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of C 8 -C 24, in particular C 12 -C 18 C atoms. The fatty acid triglycerides can be selected, for example, advantageously from the group of synthetic, semi-synthetic and natural oils, such as. Olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, castor oil, wheat germ oil, grapeseed oil, thistle oil, evening primrose oil, macadamia nut oil and the like. Further polar oil components can be selected from the group of esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of C 3 -C 30 C atoms and saturated and / or unsaturated, branched and / or unbranched alcohols of one chain length of C3-C30 C atoms and from the group of esters of aromatic carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of C3-C30 C atoms. Such ester oils can then advantageously be selected from the group isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyl dodecyl palmitate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl erucate, Dicaprylyl carbonate (Cetiol CC) and cocoglycerides (Myritol 331), butylene glycol dicapyrate / dicaprate and dibutyl adipate, as well as synthetic, semi-synthetic and natural mixtures of such esters, such as jojoba oil.

Furthermore, one or more oil or wax components can be advantageously selected from the group of branched and unbranched hydrocarbons and waxes, the polyolefin fine, the silicone oils, the dialkyl ethers or the group of saturated or unsaturated, branched or unbranched alcohols. Among the polyolefins, polydecenes are the preferred substances. Any mixtures of such oil or wax components are advantageous to use in the context of the present invention. It may also be advantageous to use waxes, for example cetyl palmitate, as the sole lipid component of the oil phase. Advantageously, one or more oil or wax components selected from the group 2-ethylhexyl isostearate, octyldodecanol, Isotridecylisononanoat, isoeicosane, 2-ethylhexyl cocoate, Ci2-Cis-alkyl benzoate, caprylic-capric triglyceride, dicaprylyl ether. Advantageous are mixtures of C 12 -C 18 -alkyl benzoate and 2-ethylhexyl isostearate, mixtures of C 12 -C 15 -alkyl benzoate and isotridecyl isononanoate and also mixtures of C 12 -C 18 -alkyl benzoate, 2-ethylhexyl isostearate and isotridecyl isononanoate. Particular preference is given to using oils having a polarity of 5 to 50 mN / m as fatty acid triglycerides, in particular soybean oil and / or almond oil. Furthermore, one or more oil or wax components can be advantageously selected from the group of Guerbet alcohols. Guerbet alcohols are named after Marcel Guerbet, who first described their production. They arise according to the reaction equation

R

R - CH ₂ --CH ₂ --OH - ... 1: *, R - CH - C - Hgr - OH

catalyst

by oxidation of an alcohol to an aldehyde, by aldol condensation of the aldehyde, elimination of water from the aldol and hydrogenation of allyl aldehyde. Guerbet alcohols are fluid even at low temperatures and cause virtually no skin irritation. Advantageously, they can be used as greasing, overfatting and also moisturizing ingredients in cosmetic compositions. The use of Guerbet alcohols in cosmetics is known per se. Such species are usually characterized by the structure

R-CH- _CHj OH

R ⁶

out. R ⁵ and R ^{6 are} generally unbranched alkyl radicals. Advantageously Guerbet alcohols are used in which R ⁵ = propyl, butyl, pentyl, hexyl, heptyl or octyl and R ⁶ = hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl or tetrad ecyl. Particularly preferred Guerbet alcohols are 2-butyl (for example as lsofol ^® 12 (Condea) commercially available) and 2-hexyl decanol (for example as lsofol ^® 16 (Condea) commercially available). Also mixtures of Guerbet alcohols may be advantageously verwendt, for example mixtures of 2-butyloctanol and 2-hexyl decanol (for example as lsofol ^® 14 (Condea) commercially available).

Any mixtures of such oil or wax components can be used advantageously.

Advantageously, the oil or wax component may also contain or consist entirely of cyclic or linear silicone oils, although it is preferred to use an additional content of other oil or wax components in addition to the silicone oil or silicone oils. Low molecular weight silicones or silicone oils are generally defined by the following general formula:

R ⁷

R-O-Si-OR ⁹

R ¹⁰

Higher molecular weight silicones or silicone oils are generally defined by the following general formula

wherein the silicon atoms may be substituted with identical or different alkyl radicals and / or aryl radicals, which are here generalized by the radicals R ⁷ to R ¹⁰ . However, the number of different residues is not necessarily limited to 4. You can assume values of 2 to 200,000.

Advantageously, cyclic silicones can also be used. Cyclic silicones are usually defined by the following general formula

wherein the silicon atoms can be substituted with identical or different alkyl radicals and / or aryl radicals, which are here generalized by the radicals R ⁷ to R ¹⁰ are. However, the number of different residues is not necessarily limited to 4, and "n" may be 3/2 to 20. Broken values for n take into account that odd numbers of siloxyl groups may be present in the cycle. Advantageously, phenyltrimethicone is chosen as the silicone oil. Other silicone oils, for example dimethicone, hexamethylcyclotrisiloxane, phenyldimethicone, cyclomethicone (octamethylcyclo tetrasiloxane), hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane), cetyl dimethicone, behenoxydimethicone, are to be used advantageously in the context of the present invention. Also advantageous are mixtures of cyclomethicone and Isotridecylisononanoat, and those of cyclomethicone and 2-Ethylhexylisostearat. However, it is also advantageous to choose SiIi konöle similar constitution as the above-mentioned compounds whose organic side chains are derivatized, for example, polyethoxylated and / or polypropoxylated. These include, for example Polysiloxanpolyalkyl-polyether copolymers such as cetyl dimethicone copolyol. Cyclomethicone (octamethylcyclo tetrasiloxane) is used particularly advantageously as silicone oil. Further advantageously usable fats and / or waxes can be selected from the group of vegetable waxes, animal waxes, mineral waxes and petrochemical waxes. Advantageous are, for example, candelilla wax, carnauba wax, Japan wax, Esparto grass wax, cork wax, guaruma wax, rice germ oil wax, sugarcane wax, berry wax, ouricury wax, montan wax, jojoba wax, shea butter, beeswax, shellac wax, spermaceti, lanolin (wool wax), crescent fat, ceresin, ozokeite (Earthwax), paraffin waxes and microwaxes.

Further advantageous Fette and / or waxes are chemically modified waxes and synthetic waxes, such as Syncrowax ^® HRC (glyceryl tribehenate), and Syncrowax ^® AW 1 C (CI8-C36-fatty acid) as well as Montanesterwachse, sasol waxes, hydrogenated jojoba waxes, synthetic or modified beeswaxes such as dimethicone copolyol beeswax and / or C30 Cδo alkyl beeswax, cetyl ricinoleate such as Tegosoft ^® CR, polyalkylene waxes, polyethylene glycol waxes, but also chemically modified fats such as hydrogenated vegetable oils (for example hydrogenated castor oil and / or hydrogenated coconut fatty glycerides), triglycerides such as hydrogenated soy glyceride, trihydroxystearin, fatty acids, fatty acid esters and glycol esters such as C2o-C4o-alkyl stearate, C2o-C4o-Alkylhydroxy- stearoylstearat and / or glycol montanate. Also advantageous are certain organosilicon compounds which have similar physical properties to the fatty and / or wax components mentioned, for example stearoxytrimethylsilane. The fats and / or waxes can be used both individually and as a mixture in the compositions. Any mixtures of such oil and wax components are also advantageous to use in the context of the present invention. Advantageously, the oil phase is selected from the group consisting of 2-ethylhexyl isostearate, octyldodecanol, isotridecyl isononanoate, butylene glycol dicaprylate / dicaprate, 2-ethylhexyl cocoate, C 12 -is alkyl benzoate, caprylic capric acid triglyceride, dicaprylyl ether. Particularly advantageous are mixtures of octyldodecanol, caprylic-capric triglyceride, dicaprylyl ether, dicaprylyl carbonate, cocoglycerides or mixtures of Ci2-Ci5-alkyl benzoate and 2-Ethylhexylisostearat, mixtures of Ci2-cis-alkyl benzoate and butylene, glycol and dicaprylate / dicaprate and mixtures of C 12-Cis-alkyl benzoate, 2-ethylhexyl isostearate and isotridecyl isononanoate. Of the hydrocarbons, paraffin oil, Cycloparaffin, squalane, squalene, hydrogenated polyisobutene or polydecene advantageous to use in the context of the present invention.

The oils can also be selected from the group of phospholipids. The phospholipids are phosphoric acid esters of acylated glycerols. Of the utmost importance among the phosphatidylcholines are, for example, the lecithins, which are characterized by the general structure

in which R ¹¹ and R ^{12 are} typically straight-chain aliphatic radicals having 15 or 17 carbon atoms and up to 4 cis double bonds.

When according to the invention advantageous paraffin oil may according to the invention Mercury Weissoel Pharma 40 from Merkur Vaseline, Shell Ondina ^® 917, Shell Ondina ^® 927, Shell Oil 4222, Shell Ondina ^® 933 from Shell & DEA OiI, Pioneer ^® 6301 S, Pioneer ^® 2071 (Hansen & Rosenthal). Suitable cosmetically acceptable oil and fat components are described in Karl-Heinz Schrader, Grundlagen und Rezepturen der Kosmetika, 2nd edition, Verlag Hüthig, Heidelberg, pp. 319-355, which is hereby incorporated by reference in its entirety.

Ethiolated glycerol fatty acid esters

Examples of ethoxylated glycerol fatty acid esters which can be used are: PEG-10 ON venoelglycerides, PEG-11 avocado oil glycerides, PEG-1 1 cocoa butter glycerides, PEG-13 sunflower oil glycerides, PEG-15 glyceryl isostearate, PEG-9 coconut fatty acid glycerides, PEG-54 hydrogenated castor oil , PEG-7 hydrogenated castor oil, PEG-60 hydrogenated castor oil, jojoba oil ethoxylate (PEG-26 jojoba fatty acids, PEG-26 jojoba alcohol), glycereth-5 cocoate, PEG-9 coconut fatty acid glycerides, PEG-7 glyceryl cocoate, PEG-45 palm oil glycerides, PEG-35 castor oil, olive oil PEG-7 esters, PEG-6 caprylic acid / capric acid glycerides, PEG-10 olive oil glycerides, PEG-13 sunflower oil glycerides, PEG-7 hydrogenated castor oil, hydrogenated palm kernel oil glyceride PEG-6 esters, PEG 20 corn oil glycerides, PEG-18 glyceryl olead cocoate, PEG-40 hydrogenated castor oil, PEG-40 castor oil, PEG-60 hydrogenated castor oil, PEG-60 corn oil glycerides, PEG-54 hydrogenated castor oil, PEG-45 palm oil glycerides, PEG-35 castor oil, PEG-80 glycerin lcocoat, PEG-60 almond oil glycerides, PEG-60 "Evening Primrose" glycerides, PEG-200 hydrogenated glyceryl palmat and PEG-90 glyceryl isostearate.

Ethoxylated oils

Preferred ethoxylated oils are PEG-7 glyceryl cocoate, PEG-9 coconut glycerides, PEG-40 hydrogenated castor oil, PEG-200 hydrogenated glyceryl palmat. Ethoxylated glycerol fatty acid esters are used in aqueous cleaning formulations for various purposes. Low ethoxy Lierte glycerol fatty acid esters (3-12 ethylene oxide units) are usually used as a moisturizer to improve the skin feel after drying, glycerol fatty acid esters with a degree of ethoxylation of about 30-50 serve as solubilizers for non-polar substances such as perfume oils. Highly ethoxylated glycerol fatty acid esters are used as thickeners. All these substances have in common that they produce on the skin when used in dilution with water, a special skin feel

surfactants

Suitable surfactants are all surface-active and wash-active substances. For example, there may be used phosphoric acid esters and salts such as DEA-oleth-10 phosphate and dilaureth-4-phosphate, alkylsulfonates such as sodium cosmonoglyceride sulfate, sodium C12-14 olefinsulfonate, sodium laurylsulfoacetate and magnesium PEG-3 cocamide sulfate, carboxylic acids and derivatives. such as lauric acid, aluminum stearate, magnesium alkoxide and zinc undecylenate, ester carboxylic acids, for example calcium stearoyl lactylate, laureth-6 citrate and sodium PEG-4 lauramide carboxylate, esters which are formed by esterification of carboxylic acids with ethylene oxide, glycerol, sorbitan or other alcohols, ethers, for example, ethoxylated alcohols, ethoxylated lanolin, ethoxylated polysiloxanes, propoxylated POE ethers and alkyl polyglycosides such as lauryl glucoside, decyl glycoside and cocoglycoside.

Polysorbate

Suitable polysorbates are, for example: polyoxyethylene (20) sorbitan monolaurate (Tween 20, CAS No. 9005-64-5)

Polyoxyethylene (4) sorbitan monolaurate (Tween 21, CAS No. 9005-64-5)

Polyoxyethylene (4) sorbitan monostearate (Tween 61, CAS No. 9005-67-8)

Polyoxyethylene (20) sorbitan tristearate (Tween 65, CAS No. 9005-71 -4)

Polyoxyethylene (20) sorbitan monooleate (Tween 80, CAS No. 9005-65-6) - polyoxyethylene (5) sorbitan monooleate (Tween 81, CAS No. 9005-65-5)

Polyoxyethylene (20) sorbitan trioleate (Tween 85, CAS No. 9005-70-3). Particularly advantageous are in particular

Polyoxyethylene (20) sorbitan monopalmitate (Tween 40, CAS No. 9005-66-7)

Polyoxyethylene (20) sorbitan monostearate (Tween 60, CAS No. 9005-67-8).

conditioners

As conditioning agents, for example, all compounds described in Section 4 of the International Cosmetic Ingredient Dictionary and Handbook (Volume 4, Ed. RC Pepe, JA Wenninger, GN McEwen, The Cosmetic, Toiletry, and Fragrance Association, 9th Edition, 2002) may be used Hair Conditioning Agents, Humectants, Skin Conditioning Agents, Skin Conditioning Agents Emollient, Skin Conditioning Agents Humectant, Skin Conditioning Agents-Miscellaneous, Skin-Conditioning Agents-Occlusive and others Skin Protectans are listed as well as all compounds listed in EP-A 934 956 (pages 11-13) under "water soluble conditioning agent" and "oil soluble conditioning agent." Other substances which can advantageously be used as conditioning agents are, for example, those according to INCI Polyquaternium compounds (in particular Polyquaternium-1 to Polyquaternium-56) The substances which can be used include, for example, polymeric quaternary ammonium compounds, cationic cellulose derivatives and polysaccharides The conditioning agents which can also be used are the compounds shown in the following table.

Table 3: Substances which can be used advantageously as conditioning agents

More advantageously be used as conditioning agent substances are for example CEI lulosederivate and quaternized guar gum derivatives, in particular guar Hydroxypropylammo- niumchlorid (z. B. Jaguar Excel ^®, Jaguar ^® C 162 (Rhodia), CAS 65497-29-2, CAS 39421-75- 5). And nonionic poly-N-vinylpyrrolidone / polyvinyl acetate copolymers (z. B. Luviskol ^® VA 64 (BASF Aktiengesellschaft)), anionic acrylate copolymers (eg. B. Luviflex Soft ^® (BASF equity company)), and / amphoteric amide / acrylate / methacrylate copolymers (e.g., B. Amphomer ^® (National starlings)) can be used advantageously in the present invention as conditioning agents.

powder raw materials

An addition of powder raw materials can be generally advantageous. As powder raw material, various substances can be used. Particularly preferred is the use of talc.

Dyes Dyes are all liquid or in a solvent, eg. B. in the application medium soluble dyes or colored substances into consideration. For dermocosmetics, pharmaceuticals, food and feedstuffs, dyes are preferably used which are suitable for use on humans and animals, i. which usually show no harmful or allergenic effects, and are approved. Examples of such dyes are in the publication "Cosmetic Colorants" of the Dye Commission of the Deutsche Forschungsgemeinschaft, published by Verlag Chemie, Weinheim, 1984, compiled. The compounds (V) can be used as dyes. If the abovementioned compounds (V) are used in addition to dyes, these dyes are merely intended to mean further dyes which do not comprise the abovementioned compounds (V).

pigments

Substances usable as pigments are practically insoluble colored substances in the application medium and may be inorganic or organic. Also inorganic-organic mixed pigments are possible. Preference is given to inorganic pigments. The advantage of inorganic pigments is their excellent light, weather and temperature resistance. The inorganic pigments may be of natural origin, for example made from chalk, ocher, umber, green earth, baked Terra di Siena or graphite. The pigments may be white pigments such. As titanium dioxide or zinc oxide to black pigments such. B. iron oxide black, colored pigments such. Example, ultramarine or iron oxide red, luster pigments, metal effect pigments, pearlescent pigments and fluorescence or Phosphoreszenzpigmente act, preferably at least one pigment is a colored, non-white pigment. Suitable are metal oxides, hydroxides and oxide hydrates, mixed phase pigments, sulfur-containing silicates, metal sulfides, complex metal cyanides, metal sulfates, chromates and molybdates and the metals themselves (bronze pigments). Titanium dioxide (Cl 77891), black iron oxide (Cl 77499), yellow iron oxide (Cl 77492), red and brown iron oxide (Cl 77491), manganese violet (Cl 77742), ultramarines (sodium aluminum sulfosilicates, Cl 77007, Pigment Blue 29 ), Chromium oxide hydrate (C177289), iron blue (Ferric Ferro-Cyanide, CI7751 0), Carmine (Cochineal). Particular preference is given to pearlescent and color pigments based on mica or mica which are mixed with a metal oxide or a metal oxychloride, such as titanium dioxide or bismuth oxychloride, and optionally further coloring agents, such as iron oxide. are coated, iron blue, ultramarines, carmines, etc. and wherein the color may be determined by varying the layer thickness. Such pigments are sold, for example under the trade names Rona ^®, Colorona ^®, Dichrona and Timiron ^{® ®} (Merck). Organic pigments include, for example, the natural pigments sepia, cambogia, bone charcoal, Kasseler brown, indigo, chlorophyll and other plant pigments. Synthetic organic pigments are, for example, azo pigments, anthraquinoids, indigoids, dioxazine, quinacridone, phthalocyanine, isoindolinone, perylene and perinone, metal complex, alkali blue and diketopyrrolopyrrole pigments.

pearlizing

Substances which can be used as pearlescing agents are those substances which can produce or impart a gloss effect. For example, these are alkylene glycol esters, special ethylene glycol disterate; Fatty acid alkanolamides, especially coconut fatty acid diethanoamide; Partial glycerides, especially stearic acid monoglyceride; Esters of polybasic, optionally hydroxysubstituted carboxylic acids with fatty alcohols with C6-C22 carbon atoms, especially long-chain esters of tartaric acid; Fats, such as fatty alcohols, fatty ketones, fatty aldehydes, fatty ethers and fatty carbonates, which in total have at least 24 carbon atoms, especially laurone and distearyl ether; Fatty acids such as stearic acid, hydroxystearic acid or behenic acid, ring-opening products of olefin epoxides with C 12 -C 22 carbon atoms with fatty alcohols having C 12 -C 22 carbon atoms and / or polyols with C 2 -C 15 carbon atoms and C 2 -C 10 hydroxyl groups and mixtures thereof.

thickener

Thickeners are substances that can increase the viscosity. For example, they can be used to increase the viscosity of a mixture. Examples of suitable thickeners are crosslinked polyacrylic acids and their derivatives, polysaccharides and their derivatives, such as xanthan gum, agar-agar, alginates or tyloses, cellulose derivatives, eg. As carboxymethylcellulose or hydroxycarboxymethylcellulose, fatty alcohols, monoglycerides and fatty acids, polyvinyl alcohol and polyvinylpyrrolidone can be used. Nonionic thickeners are preferably used.

repellent

Repellent agents are compounds that are capable of certain animals, in particular

Insects, by humans or animals, such as farm animals and pets, to discourage or distribute. For example, 2-ethyl-1,3-hexanediol, N, N- can be used for this purpose.

Diethyl-m-toluamide, etc. Suitable hyperemic substances which stimulate the circulation of the skin are, for. For example, essential oils such as mountain pine extract, lavender extract, rosemary extract, juniper berry extract, horse chestnut extract, birch leaf extract, hay flower extract, ethyl acetate, camphor, menthol, peppermint oil, rosemary extract, eucalyptus oil, etc. Suitable keratolytic and keratoplastic substances are, for. As salicylic acid, calcium thioglycol lat, thioglycolic acid and its salts, sulfur, etc. Suitable anti-dandruff agents are, for. Sulfur, sulfur polyethylene glycol sorbitan monooleate, sulfur ricinol polyethoxylate, zinc pyrithione, aluminum pyrithione, etc. Suitable antiphlogistic agents which counteract skin irritation are e.g. Allantoin, bisabolol, dragosantol, chamomile extract, panthenol.

Pharmaceutically acceptable polymers As pharmaceutically acceptable polymers are, for example, cationic polymers called Polyquaternium INCI, z. B. Copolymers of vinylpyrrolidone / N-vinylimidazolium salts (Luviquat FC, Luviquat HM, Luviquat MS, Luviquat & commat, Care), copolymers of N-vinylpyrrolidone / dimethylaminoethyl methacrylate, quaternized with diethyl sulfate (Luviquat PQ 1 1), copolymers of N-vinylcaprolactam / N-vinylpyrrolidone / N-vinylimidazolium salts (Luviquat E Hold), cationic cellulose derivatives (Polyquaternium-4 and -10), acrylamidocopolymers (Polyquaternium-7) and chitosan.

Suitable cationic (quaternized) polymers are also Merquat (polymer based on dimethyldiallylammonium chloride), gafquat (quaternary polymers which are formed by reaction of polyvinylpyrrolidone with quaternary ammonium compounds), polymer JR (hydroxyethylcellulose with cationic groups) and cationic polymers on vegetable Base, z. As guar polymers, such as the Jaguar ^® brands from Rhodia.

Further substances which can be used as polymers are neutral polymers, such as polyvinylpyrrolidones, copolymers of N-vinylpyrrolidone and vinyl acetate and / or vinyl propionate, polysiloxanes, polyvinylcaprolactam and other copolymers with N-vinylpyrrolidone, polyethyleneimines and their salts, polyvinylamines and their salts, cellulose derivatives, polyaspartic acid salts and derivatives. This includes, for example Luviflex® ^® 0 Swing (partially hydrolyzed copolymer of polyvinyl acetate and polyethylene glycol, BASF Aktiengesellschaft).

Suitable polymers are also nonionic, water-soluble or water-dispersible polymers or oligomers, such as polyvinyl caprolactam, z. B. Luviskol ^® 0 Plus (BASF), or polyvinylpyrrolidone and their copolymers, in particular with vinyl esters, such as vinyl acetate, z. B. Luviskol ^® 0 VA 37 (BASF), polyamides, z. B. based on itaconic acid and aliphatic diamines, as z. B. in DE-A-43 33 238 are described.

Suitable polymers are also amphoteric or zwitterionic polymers, such as those available under the names Amphomer ^® (National Starch) octylacrylamide / methyl methacrylate / tert-butylaminoethyl methacrylate hydroxypropyl methacrylate copolymers and zwitterionic polymers, as described for example in German patent applications DE39 29 973, DE 21 50 557, DE 28 17 369 and DE 37 08 451 are disclosed. Acrylamidopropyltrimethylammonium chloride / acrylic acid resp. Methacrylic acid copolymers and their alkali metal and ammonium salts are preferred zwitterionic polymers. Further suitable zwitterionic polymers are methacroylethylbetaine / methacrylate copolymers (AMERCHOL) are commercially available under the name Amersette® ^®, and copolymers of hydroxyethyl methacrylate, methyl methacrylate, N, N-dimethylaminoethyl methacrylate and acrylic acid (Jordapon (D)). Suitable polymers are also nonionic, siloxane-containing, water-soluble or -dispersible polymers, for. As polyether siloxanes, such as Tegopren ^® 0 (Goldschmidt) or Besi & commat (Wacker).

Solids or liquids or mixtures thereof

The term solids or liquids or mixtures thereof is to be understood very broadly. These are to be understood as meaning, in principle, all solids or liquids or mixtures thereof which occur naturally or are artificially preparable, with the exception of antioxidants, mixtures (M1) and (M2), preparations, colorants, vesicles, carotenoid formulations, dermocosmetics, pharmaceuticals, food and feed. Not included are the natural sources of the compounds (V) as well as the compounds (V) themselves. This includes preferably all tradable products. On the one hand, products are basic and precursor products that can be used to manufacture sales products and the sales products themselves. According to one of the preferred embodiments, these are adhesives. In another preferred embodiment, these include paints, dyes and other dyes. In another embodiment, solids or liquids or mixtures thereof are solvents, monomers, oligomers and polymers. Other forms of stirring may be fuels and mineral oils. Embodiments may also be construction chemicals and building materials. Embodiments are also chemicals for agriculture, for example crop protection or fertilizers. In another embodiment, they are dispersions and, in another exemplary embodiment, colored papers.

Preparation of compounds (V)

Compounds (V) belong to the class of aromatic carotenoids. Carotenoids are widespread in nature and occur in a large variability. Carotenoids are produced by many photosynthetically active and some photosynthetically inactive organisms. The biochemical pathway to the basic carotenoid structure is well studied and is the same for most of the organisms (Armstrong, G., 1999, in D.H.R. Barton & K. Nakanishi, Comprehensive Natural Products Chemistry, Vol. 2, 321-352).

Under natural circumstances, 3,3'-dihydroxyisorenieratin is present in microorganisms such as Streptomyces mediolani or Brevibacterium linens. Brevibacterium linens coexists with its biochemical precursors (isornenine and 3-hydroxyisorenieratin) and is responsible for the yellow-reddish color of the bacterium (Kohl et al., 1983, Phytochemistry 22, 207-210). Brevibacterium linens in turn is a component of the complex compound bacteria smear on red smear cheese for example on Limburger, Münster, Brick, Tilsiter and Appenzeller and can be isolated from there. To facilitate finding colonies containing 3,3'-dihydroxyisorenieratin, one can take advantage of reacting with alkali. The resulting ionization of the phenolic ring has a bathochromic Effect resulting in a color change from yellow-orange to pink-violet (Rattray, FP, Fox, PF 1999, Journal of Dairy Science, 82, 891-909).

3,3'-Dihydroxyisorenieratin can be prepared in a variety of ways. Up to now, isolation from microorganisms has been preferred. DE 18 08 514 A1 discloses a process for the preparation of 3,3'-dihydroxyisorenieratin. In the process, a 3,3'-Dihydroxyisorenieraten producing organism (Streptomyces mediolani) is grown in culture and added to feed as dried and ground cell powder. Alternatively, an extract of this organism containing 3,3'-dioxyisorenieratin can be used.

WO 2005/007826 A2 describes a process by means of which cyclic carotenoids are converted by bioconversion into aryl carotenoids. For this purpose, a codon-optimized gene of a carotene desaturase is expressed in a Gram-negative host cell. Isorenieratin can be produced by this method, which can act as a precursor for the production of 3,3'-dihydroxyisorenieratin in bacterial metabolism.

A scientific publication has described a gene for a cytochrome P450 monooxygenase from Brevibacterium aurantiacum, whose gene product is highly likely to bioconvert isore renates to 3,3'-dihydroxyisorenieratin (Dufosse, L et al., The last Step in the biosynthesis brevibacterium linens ATCC 9175 (Brevibacterium aurantiacum sp., Nov) involves a cytochrome P450 monooxygenase, Food Research International, 2005, 38, 967-973).

Alternatively, 3,3'-dihydroxyisorenieratin can be synthesized. Possible synthesis routes are described in documents EP 06116819.1 and EP 06116816.7.

By oxidation, 3,3'-dihydroxyisorenieratin can be converted to the blue isomerieratin-3,3'-dichinone (II) (Nybraaten G., Liaaen-Jensen S., Characterization of Phenolic Carotenoids, Acta Chemica Scandinavica, 1971, 25, 370 -372). It will therefore be understood that the intermediate of these reactions, the 3-hydroxyisorenieratin-3'-quinone, is found in both 3,3'-

Dihydroxyisorenieratin and in lsorenieratin-3,3'-dichinone or mixtures thereof may occur. The preparation of 2,2 ', 4,4'-tetra-tert-butylisorenieratin-3,3'-dichinone (III) and 3,3'-dihydroxy-2,2', 4,4'-tetra-tertiary butylisorenieratin (IV) is described in the dissertation by Markus Schmidt (University of Düsseldorf, 2001, page 35 ff).

The compounds (V) or their compounds which are used in the antioxidants of the invention, mixtures (M1 or (M2), preparations, colorants, vesicles, carotenoid formulations, dermocosmetics, pharmaceuticals, food and feed or the solids or liquids or mixtures or used for their preparation Mixtures, in particular the 3,3'-dihydroxyisorenieratin used, can be produced by the natural or altered metabolism of an organism or can be wholly or partly synthesized. be siert. Metabolism of organisms can be influenced, for example, by special fermentation techniques such as biocatalysis or genetic manipulation. The compounds (V) are advantageously used in enriched form and / or in pure form. This is especially true for compound (I), especially for 3,3'-dihydroxyisorenieratin. An enriched form is to be understood as meaning a concentration of the particular compound considered which is higher than the concentration in which the particular compound occurs in its natural source, for example in Streptomyces mediolani or Brevifobium linens. If several natural sources of compounds (V) are available, the concentration will refer to the natural source or sources from which it has been enriched. In the enriched form, this concentration is preferably 2x, 3x, 4x, 5x, 6x, 7x, 8x, 9x, 10x, 2Ox, 3Ox, 4Ox, 5Ox, 6Ox, 70x, 8Ox, 9Ox, 100x, or more than 100x higher. In pure form, the compounds (V) having a purity in the range of 1 to 100 wt .-%, preferably 10 to 100 wt .-%, more preferably in a range of 30 to 100 wt .-%, most preferably from 50 to 100 wt .-% and most preferably from 75 to 100 wt .-% based on the total weight of the above-mentioned compounds before. Particular preference is given to crystals of the respective compounds (V) having a purity of greater than 75% by weight, preferably greater than 90% by weight, particularly preferably greater than 95% by weight, very particularly preferably greater than 98% by weight, based on the total weight of the respective crystals used. Compounds (V) or mixtures thereof derived from natural sources may be mixed with other carotenoids and phospholipids. The content of further carotenoids, with the exception of the compounds (V) and phospholipids for each of the compounds (V) is preferably below a weight proportion of 95%, 90%, 80%, 70%, 60%, 50%, 40% 30%, 20 %, 10%, 5%, 1%, 0.5% or 0.05%, based on the total weight of the respective compound.

They are particularly advantageously used with a low phospholipid content which can be determined approximately via the phosphorus content. The phosphorus content should, especially for the compounds (V) used in carotenoid formulations, less than 2 wt .-%, advantageously less than 1, 0 wt .-%, preferably less than 0.5 wt .-%, especially before - At less than 0.1 wt .-%, most preferably less than 0.02 wt .-%, based on the total amount of the carotenoid formulation be.

In order to improve the solubility, the color yield and / or the absorbability of the compounds (V), the compounds (V) are preferably present in micronized form, for example as dry powder. In micronized form, the compounds have a small particle size. Advantageously, the particle size is less than 10 microns, preferably less than 5 microns and more preferably less than 1 micron and most preferably less than 0.3 microns. The half-width of the particle size distribution is advantageously less than 70%, preferably less than 60%, more preferably less than 50% and most preferably less than 40% of the particle size. In a further preferred embodiment, the compounds (V) or the compounds (V) are in micronized form, in conjunction with a protective colloid, a coating, in admixture with vitamins or in a combination of these. The preparation of such dry powders is described for example in EP 0 065 193 A2, in EP 0 835 613 B1 or described in WO 91/06292 A1, wherein the compounds (V) similar to the other carotenoids described in these documents, such as ß-carotene or astaxanthin, can be used. The particle size is preferably determined by laser photon correlation spectroscopy according to B. Chu., Laser Light Scattering; Academic Press, New York 1974.

antioxidants

The present invention relates to antioxidants containing at least one iso-reninatin compound (I). According to one of the preferred embodiments, the antioxidants according to the invention contain only one isorenieratin compound (I). Particularly preferred 3,3'-Dihydroxyisorenieratin is used as the inventive antioxidant. In one embodiment, the antioxidants of the invention may contain one or more isorenieratin compounds (I). In another embodiment, in addition to the isorenieratin compounds (I), one or more compounds (II) to (IV) may be present in the antioxidants according to the invention. In another preferred embodiment, the antioxidant of the invention may additionally contain other substances in addition to one or more isorenieratin compounds (I). For example, other antioxidants, peroxide decomposers, radical decomposers or other carotenoids are advantageous. Of these, the antioxidants according to the invention preferably contain for example a mixture (M1) containing at least one iso-reninatin compound (I) and isorenieratin-3,3'-dichinone (II) or 2,2 ', 4,4'-tetra-tert - butylisorenieratin-3,3'-dichinone (III) or mixtures thereof, or mixture (M2) containing, 3'-dihydroxy-2,2 ', 4,4'-tetra-tert-butylisorenieratin (IV) and at least an isorenated urate compound (I) or a mixture (M1).

The antioxidants of the invention may consist of an antioxidant component or of several antioxidant components. These antioxidant components are the above-mentioned compounds (V), preferably 3,3'-dihydroxyisorenieratin, their mixtures and other substances, for example other antioxidants, peroxide decomposers, radical decomposers, organic and inorganic solvents, oils, fats or waxes. For the preparation of the antioxidants according to the invention, the antioxidant constituents can be used in enriched, pure, crystalline or micronized form. The antioxidant components may be present in solid form or in a suitable solvent. Suitable solvents are, for example, organic or inorganic solvents or fats, oils and waxes. Preference is given here to organic or inorganic solvents, fats, oils and waxes which are approved dermocosmetically, pharmaceutically, for human or for animal consumption or for several of these purposes. The antioxidant components can be mixed in one step or in several steps. When at least one liquid antioxidant ingredient is used, the antioxidant may then be dried or left as is.

The amount of each compound selected from compounds (V) to the other antioxidant components may vary depending on the number of antioxidant components and the use of the same. purpose and desired properties of the antioxidant. For example, it may range from 0.01%, 0.05%, 1%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95% % or 100 wt .-% based on the total weight. The proportions of the other antioxidant components are also very variable and can vary for each additional antioxidant component in the same ranges.

The antioxidants of the invention may be used in a process for the preparation of mixtures, preparations, colorants, vesicles, carotenoid formulations, dermocosmetics, pharmaceuticals, food or feed, gelatin capsules or other solids or liquids or mixtures thereof.

Mixtures (M1) and (M2)

Another object of the invention are mixtures (M1) containing at least one iserenearatin compound (I) and isorenieratin-3,3'-dichinone (II) or 2,2 ', 4,4'-tetra-tert-butylisorenieratin 3,3'-Dichinone (III) or mixtures of these or mixtures (M2) containing 3,3'-dihydroxy-2,2 ', 4,4'-tetra-tert-butylisorenieratin (IV) and at least one isorenieratin - Compound (I) or a mixture (M1). The mixtures (M1) or (M2) preferably contain 3,3'-dihydroxyisorenieratin as isorenieratin compound (I).

The mixtures (M1) or (M2) according to the invention may consist of a mixture constituent or of several constituents of the mixture. These compounding components are compounds (V), preferably 3,3'-dihydroxyisorenieratin, their mixtures and other substances, for example other antioxidants, peroxide decomposers, radical decomposers, organic and inorganic solvents, oils, fats or waxes. For the preparation of the mixtures (M1) or (M2), the mixture components can be used in enriched, pure crystalline or micronised form. The components of the mixture may be present in solid form or in a suitable solvent. Suitable solvents are, for example, organic or inorganic solvents or fats, oils and waxes. Preference is given here to organic or inorganic solvents, fats, oils and waxes which are approved dermocosmetically, pharmaceutically, for human or for animal consumption or for several of these purposes. The mixture components can be mixed in one step or in several steps. If at least one liquid mixture component has been used, the mixtures (M1) or (M2) can then be dried or left as they are.

The amount of the particular compound selected from compounds (V) to the other compounding ingredients may be varied depending on the number of compounding ingredients and the intended use and desired properties of the mixtures (M1) or (M2). For example, it may range from 0.01%, 0.05%, 1%, 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95% % or 100 wt .-% based on the total weight. The proportions of the other components of the mixture are also very high variable and may vary for each further mixture component in the same areas.

The compounds (V) or the mixtures (M1) or (M2) are suitable for the preparation of mixtures in which material properties are to be positively combined or influenced. If, in addition to a high antioxidant effect, value is also attached to a particular color impression, for example the 3,3'-dihydroxyisorenieratin can also be used as a mixture with the blue isorenieratin-3,3'-dichinone (II) or with the red BHT carotenoid ( IV) or 2,2 ', 4,4'-tetra-tert-butylisorenieratin-3,3'-dichinone (III) or other isorenieratin compounds (I) or other carotenoids or with mixtures of these. Due to the different colors and the high antioxidant effect, it is possible to prepare different mixtures (M1) or (M2) with different colors and antioxidant effects. The mixtures (M1) or (M2) can be used for many purposes and must be adapted in their composition to the respective purpose. By the composition of the mixtures (M1) or (M2) not only the antioxidant effect or the coloring, but also for example the health properties can be positively influenced or the properties of vesicles, for example their stability or coloring, can be varied.

The mixtures (M1) or (M2) are suitable for the preparation of preparations, colorants, vesicles, carotenoid formulations, dermocosmetics, pharmaceuticals, foodstuffs or feedstuffs, gelatin capsules or other solids or liquids or mixtures thereof.

Preparations The preparations according to the invention can be preparations of antioxidants, mixtures (M1) or (M2), colorants, vesicles or carotenoid formulations. As a rule, the preparations contain the constituents typical of preparations, which, however, vary depending on the field of application of the preparation. The preparations according to the invention can be present as a ready-made mixture or as a combination of preparation components which are mixed before they are used. These compositions may each contain the preparation ingredients separately or may include one or more formulation ingredients separate from a mixture of other formulation ingredients. The preparation constituents may be present in different concentrations or in different forms, for example in solid, liquid or gaseous form or as a powder, crystal or emulsion. The compilations are usually provided with technical information indicating the manner and in what quantity the preparation components can be used advantageously. These technical instructions usually also contain information as to which constituents of the preparation can alternatively be used or which constituents of the preparation should not be combined. Also, the technical information may include information about how the preparation ingredients or their combinations are used for different purposes. The ingredients of the preparation may be added singly or in mixtures of one or more ingredients and, optionally, other ingredients such as solvents, at the same time or different times to dermocosmetics, pharmaceuticals, food or feed, solids or liquids, or mixtures thereof. Examples of such preparations are: nutrient concentrates or flavors.

In this case, the preparation component is understood as meaning any compound or substance which is contained in the preparation. Examples of such preparation constituents are, for example, the compounds (V), other carotenoids, further antioxidants, minerals, enzymes, vitamins, organic acids, trace elements, vitamins, enzymes, amino acids, minerals, or auxiliaries such as emulsifiers, stabilizers, preservatives, anti-caking agents, solvents or flavor enhancers.

The preparation constituents may be present, for example, in the form of liquids, dispersions, suspensions or as a solid and in the same or different enriched, pure, crystalline or micronized form.

The choice of the preparation ingredients depends on the selected field of use of the preparations. For dermocosmetic or pharmaceutical preparations, the preparation ingredients may consist of all substances suitable for dermocosmetic or pharmaceutical preparations. Food or feed preparations may consist of any substance or mixture of substances that is safe and / or authorized for human or animal consumption. These can be of natural or synthetic origin. Examples of eligible representatives of the substance classes mentioned can be found in the respectively valid lists for food additives according to European regulations, for example the currently valid EC guideline 95/2 / EG.

These preparation ingredients are added to the preparations in different amounts, according to their different properties and depending on the chosen field of use. The depending on the chosen application meaningful combinations of

Substance classes and quantitative mixing ratios are known to the person skilled in the art. The examples of preparation ingredients listed here are particularly suitable for preparations for food and feed, but can also be used in dermocosmetics, in particular in agents for oral, dental or dental care or in pharmaceuticals, provided that they are approved for these uses.

In one embodiment, the preparations can be administered independently of the food or feed as a liquid, powder, tablet, capsule or suspension to the human or animal organism in addition to or separate from the normal food or feed.

As preparation ingredients, for example, vitamins come into consideration. Preferred vitamins are: vitamin A (retinol), vitamin D (calciferols), vitamin E (tocopherols and tocotrienols), vitamin K (phylloquinones and menaquinones), with vitamins A and E being preferred.

In particular, food and feed preparations may also contain enzymes of one or more types. Examples include: amylases, phytases, proteases or invertases.

Suitable amino acid constituents are, for example, glutamic acid, L-carnitine, L-glutamine, L-taurine, L-aspartic acid, L-glycine, L-lysine, DL-phenylalanine, L-tryptophan, tyrosine, L-arginine, L-cysteine, L-leucine, DL-methionine, L-alanine, L-serine, L-threonine, L-citrulline, L-VaNn, L-histidine, L-isoleucine, L-ornithine or L-proline. Particularly preferred are the essential amino acids such. L-isoleucine, L-leucine, L-lysine, DL-methionine, DL-phenylalanine, L-threonine, L-tryptophan and L-VaNn, very particularly preferred are the important in animal nutrition amino acids L-lysine, DL- Methionine or L-threonine.

Preferred mineral substances for food and feed are, for example, sodium, potassium, magnesium, calcium, phosphorus, iron or zinc or their physiologically acceptable salts.

Suitable trace elements are: chromium, iron, fluorine, iodine, cobalt, copper, manganese, molybdenum, nickel, selenium, vanadium, zinc or tin or their physiologically acceptable salts.

Preferred organic acids for food and feedstuffs are: formic acid, propionic acid, lactic acid, acetic acid and citric acid, particular preference is given to formic acid, propionic acid or lactic acid.

Further possible constituents of the preparation, especially for food and feed, are flavor enhancers. For the purposes of this invention, flavor enhancers are naturally occurring or artificially produced substances which can round off or enhance the taste of foods and animal feeds. As flavor enhancers it is also possible to use flavors which do not contain the compounds (V). Examples include: E 620 glutamic acid, E 621 monosodium glutamate, E 622 monoclonal glutamate, E 623 calcium diglutamate, E 624 monoammonium glutamate, E 625 magnesium diglutamate, E 626 guanylic acid, E 627 disodium guanylate, E 628 dipotassium guanylate, E 629 calcium guanylate, E 630 inosinic acid, E 631 Disodium inositol, E 632 dipotassium inosinate, E 633 dicalcium inosinate, E 634 calcium 5-ribonucleotide, E 635 disodium 5-ribonucleotide, E 640 glycine and E 650 zinc acetate.

The E numbers below are the common name for food additives in Directive 95/2 / EEC. As further antioxidants z. As ascorbic acid (vitamin C, E 300), sodium L-ascorbate (E 301), calcium L-ascorbate (E 302), ascorbyl palmitate (E 304), butylhydroxyanisole (E 320), butylhydroxytoluene ( E 321), calcium disodium EDTA (E 385), gallates such. Propyl gallate (E 310), octyl gallate (E 311), dodecyl gallate (lauryl gallate) (E 312), isoascorbic acid (E 315), sodium isoascorbate (E 316), lecithin (E 322), lactic acid (E 270), multiple phosphates z. B. Diphosphates (E 450), triphosphates (E 451), polyphosphates (E 452), sulfur dioxide (E 220), sodium sulfite (E 221), sodium bisulfite (E 222), sodium disulfite (E 223), potassium sulfite (E 224), Calcium sulfite (E 226), calcium hydrogen sulfite (E 227), potassium bisulfite (E 228), selenium, tocopherols (vitamin E, E 306) such. Alpha tocopherol (E 307), gamma tocopherol (E 308), delta tocopherol (E 309) and all tocotrienols, stannous chloride (E 512), citric acid (E 330), sodium citrate (E. 331), carotenoids, vitamin A and potassium citrate (E 332).

Vitamins include both fat-soluble and water-soluble vitamins. Examples of vitamins include: vitamin B1 (thiamine), vitamin B2 (riboflavin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxine), vitamin B12 (cobalamin), vitamin C (ascorbic acid), vitamin H (biotin ), Folic acid and niacin.

Emulsifiers suitable for foodstuffs and feedstuffs are, for example, the following substances: E 420 sorbitol, E 420N sorbitol syrup, E 421 mannitol, E 422 glycerol, E 431 polyoxyethylene (40) stearate, E 432 polyoxyethylene sorbitan monolaurate / polysorbate 20, E 433 polyoxyethylene sorbitan monooleate / polysorbate 80, E 434 polyoxyethylene sorbitan monopalmitate / polysorbate 40, E 435 polyoxyethylene sorbitan monostearate / polysorbate 60, E 436 polyoxyethylene sorbitan tristearate / polysorbate 65, E 440 pectins, E 44Oi pectin, E 440N amidated pectin, E 442 ammonium phosphatide, E 444 sucrose acetate isobutyrate, E 445 glycerol ester from rosin, E 450 diphosphates, E 45Oi disodium diphosphate, E 450Ü trisodium diphosphate, E 450iii tetrasodium diphosphate, E 450iv dipotassium diphosphate, E 45Ov tetrapotassium diphosphate, E 450vi dicalcium diphosphate, E 450vii calcium dihydrogen diphosphate, E 451 triphosphate, E 451 i pentasodium triphosphate, E 451 ii pentapotassium triphosphate, E 452 polyphosphate, E 452i sodium mpolyphosphate, E 452ii potassium polyphosphate, E 452iii sodium calcium polyphosphate, E 452iv calcium polyphosphate, E 460 cellulose, E 46Oi microcrystalline cellulose, E 460N cellulose powder, E 461 methylcellulose, E 463 hydroxypropylcellulose, E 464 hydroxypropylmethylcellulose, E 465 methylethylcellulose, E 466 carboxymethylcellulose, E 469 enzymatically hydrolysed carboxymethylcellulose, E 470a sodium, potassium and calcium salts of fatty acids, E 470b magnesium salts of fatty acids, E 471 mono- and diglycerides of fatty acids, E 472a acetic acid esters of mono- and diglycerides of fatty acids, E 472b lactic acid esters of mono and di-glycerides of fatty acids, E 472c citric acid esters of mono- and diglycerides of fatty acids, E 472d tartaric acid esters of mono- and diglycerides of fatty acids, E 472e mono- and diacetyl tartaric acid esters of mono- and diglycerides of fatty acids, E 472f mixed acetic and Tartaric acid esters of mono- and diglycerides of fatty acids, E 473 sugar residue fatty acids, E 474 polyglycerol esters of fatty acids, E 476 polyglycerol polyricinoleate, E 477 propylene glycol esters of fatty acids, E 479 thermooxidised soya oil with mono- and diglycerides of fatty acids, E 481 sodium stearoyl-2-lactylate, E 482 calcium stearate royl-2-lactylate, E 483 stearyl tartrate, E 491 sorbitan monostearate, E 492 sorbitan tristearate, E 493 sorbitan monolaurate, E 494 sorbitan monooleate or E 495 sorbitan monopalmitate.

In the context of the invention, stabilizers are to be understood in particular as meaning substances which maintain the consistency or the composition of food and feed. Substances which can be used as stabilizers are: ascorbic acid (E 300), carbamite (E 927b), iron lactate (E 585), iron gluconate (E 579), glycerol ester (E 445), lecithin (E 322), meta-tartaric acid ( E 353), pectin (E 440), sucrose acetate isobutyrate (E 444) and tin-II-chloride (E 512)

Preservatives are substances which prolong the shelf life of, in particular, dermocosmetics, pharmaceuticals, food and feedstuffs, by protecting them from the harmful effects of microorganisms. Examples which may be mentioned are: E 200 sorbic acid, E 201 sodium sorbate, E 202 potassium sorbate, E 203 calcium sorbate, E 210 benzoic acid, E 211 sodium benzoate, E 212 potassium benzoate, E 213 calcium benzoate, E 214 ethyl p-hydroxybenzoate / PHB ester, E 215 sodium ethyl p-hydroxybenzoate / PHB ethyl ester sodium salt, E 216 propyl p-hydroxybenzoate / PHB propyl ester, E 217 sodium propyl p-hydroxybenzoate / PHB propyl ester sodium salt, E 218 methyl p-hydroxybenzoate / PH B Methyl ester, E 219 sodium methyl p-hydroxybenzoate / PHB methyl ester sodium salt, E 220 sulfur dioxide, E 221 sodium sulfite, E 222 sodium hydrogen sulfite / sodium bisulfite, E 223 sodium metabisulfite / sodium bisulfite, E 224 potassium metabisulfite / potassium sulfite, E 226 calcium sulfite, E 227 calcium hydrogen sulfite, E 228 potassium hydrogen sulfite / potassium bisulfite, E 230 biphenyl / diphenyl, E 231 orthophenylphenol, E 232 sodium orthophenylphenol, E 233 thiabendazole, E 234 nisin, E 235 natamycin, E 239 hexamethylenetetramine, E 242 dimethyldicar carbonate, E 249 potassium nitrite, E 250 sodium nitrite, E 251 sodium nitrate and E 252 potassium nitrate.

For the purposes of the present invention, anti-caking agents are naturally occurring or artificially produced substances which increase the flowability of a foodstuff or animal feed by preventing the particles from agglomerating and sticking together. Examples of suitable anticaking agents are E 530 magnesium oxide, E 535 sodium ferrocyanide, E 536 potassium ferrocyanide, E 541 acid sodium aluminum phosphate, E 551 silica, E 552 calcium silicate, E 553ai magnesium silicate, E 553aii magnesium trisilicate (asbestos free), E 553b talcum (asbestos free), E 554 sodium aluminum silicate or E 556 calcium aluminum silicate.

In one embodiment, the preparation used according to the invention may contain one or more additives as a preparation component. According to the invention, additives are substances which serve to improve the product properties, such as dust behavior, flow properties, water absorption capacity and storage stability. Aggregates can be based on sugars, such as lactose or maltodextrin, on the basis of cereal or legume products, for example corn cob meal, wheat bran and soybean meal, based on mineral salts, such as calcium, magnesium, sodium, potassium salts, as well as D-pantothenic acid or its salts themselves (chemically or fermentatively produced D-pantothenic acid salt).

In a further embodiment, the preparation used according to the invention may contain one or more so-called carriers as a preparation component. Suitable carriers are "inert" carrier materials, ie materials which show no negative interactions with the components used in the preparation according to the invention.Of course, the carrier material must be harmless to the respective use, for example in foodstuffs and feedstuffs Examples of suitable carrier materials are: low molecular weight inorganic or organic compounds and relatively high molecular weight organic compounds of natural or synthetic origin. Sodium sulfate and magnesium sulfate, kieselguhr or silicic acid or silicic acid derivatives, eg silicon dioxides, silicates or silica gels Examples of suitable organic carriers are, in particular, sugars, such as glucose, Fructose, sucrose, as well as dextrins and starch products. Examples of higher molecular weight organic carriers include: starch and cellulose preparations, in particular maize starch, corn cob meal, ground rice hulls, wheat bran bran or cereal flours, such as, for example, Wheat, rye, barley and oatmeal or bran and mixtures thereof.

The proportion by weight of the antioxidants of the invention, mixtures (M1) or (M2), colorants, vesicles or carotenoid formulations in the preparations according to the invention can vary within wide ranges and is generally based on practical considerations arising from the chosen field of application (eg. B. livestock, pet ownership or human nutrition).

In one embodiment of the present invention, the preparations suitable for use according to the invention may be e.g. From 1 to 10% by weight, preferably from 10 to 20% by weight, particularly preferably from 20 to 30% by weight, very particularly preferably from 30 to 40% by weight of antioxidant, mixtures (M1) or (M2), colorants, vesicles or carotenoid formulation. However, it is also possible to select higher percentile shares.

The preparation of the preparations according to the invention is carried out in the simplest case by mixing the individual components. Likewise, the preparation can be effected by mixing solutions or dispersions of the preparation constituents and, if appropriate, subsequent removal of solvents or dispersants.

The mixtures of various constituents can be present among one another in any desired weight ratios.

The simplest form of the mixture is the bringing together of the preparation ingredients in a mixer. Such mixers are known to the person skilled in the art, for example from the company Ruberg (vertical twin-shaft mixer (type HM (10-50,000 l)), ring-layer mixing granulator (type RMG), continuous agglomerator dryer (type HMTK), vertical single-shaft mixer (type VM (10-50,000 l)), container mixer (type COM (50-4000 l)) Other mixers can also be obtained from the companies Lödige, Drais, Engelsmann The mixers can be operated batchwise or continuously In the batch mixer, generally all the constituents to be mixed are charged in the desired ratio Mixing time and mixing are determined so that the components of the preparation are homogeneously distributed, ie the individual components of the preparation are evenly distributed in the preparation In the case of continuous mixing, the constituents of the preparation become continuous if necessary, after a premix, the Ver because of time and mixing stress to be chosen so that the preparation components are homogeneously distributed in the mixture. The mixing time in the continuous case is often shorter and the stress higher than in the case of the batch mixture. The mixture is usually carried out at room temperature, but can also be carried out at higher or lower temperatures, depending on the substances used.

The preparations may be in liquid form, for example as a solution, dispersion as a suspension or as a solid. In a preferred embodiment, the preparations are present as a solid. Depending on the application requirement, the preparations may be in the form of powders having an average particle size in a range from 10 μm to 5000 μm, preferably with an average particle size in a range from 20 μm to 1000 μm. The average particle size here means that at least 75% of the particles have a particle size within the specified range.

The obtained particle distribution of the pulverulent products can be examined in a device from Malvern Instruments GmbH, Mastersizer S.

Mixtures of constituents are possible as pure blends, that is, the substances are mixed together in the desired particle sizes and concentration ratios, optionally with the addition of further constituents of preparation, it also being possible for substances to be protected by coating as far as necessary. Furthermore, core-shell structures can be used, i. one or more constituents of preparation are present as core inside and one or more further constituents of preparation as shell outside - or vice versa. Of course, further enclosures are also used in these structures, if necessary. It is also conceivable to encapsulate substances together in a common matrix of carrier materials or protective colloids. Examples of these are known in the art and z. In R.A. Morten: Fat-Soluble Vitamins, Pergamon Press, 1970, pages 131-145.

The preparation of the powders can be carried out by crystallization, precipitation,

Drying, granulation or agglomeration process or other methods described in the current textbooks for the formation of solids made. dye

Another object of the invention are colorants containing the compounds (V). The colorants of the invention may consist only of the compounds (V), for example 3,3'-dihydroxyisorenieratin or dihydroxyisorenieratin-3-quinone. Likewise, it is possible that they contain or consist of different compounds (V). Furthermore, they may contain the antioxidants of the invention, mixtures (M1) or (M2), preparations, vesicles or carotenoid formulations or may have been prepared using them. In addition, they may contain other substances (colorant constituents), as commonly used in the art by colorants. Colorant ingredients may be, for example, dispersing or suspending agents, emulsifiers or fats, oils and waxes. They preferably contain other dyes and / or pigments, for example other carotenoids. For the preparation of the colorants or in the colorants, the compounds (V) are preferably in enriched form, particularly preferably in pure form and very particularly preferably in crystalline or micronized form or in the form of H or J aggregates, or in mixtures of these ,

To further increase the stability of the colorants, it is possible to use further antioxidants, peroxide decomposers, free-radical scavengers and / or emulsifiers and oils, which are preferably approved for use in or on the human or animal body or dermocosmetically and pharmaceutically acceptable, as the colorant constituent.

The colorants may be used alone or in the presence of or contain protective colloids. Protective colloids are, for example, gelatin, fish gelatin, starch, dextrin, vegetable proteins, pectin, gum arabic, casein, caseinate or mixtures thereof. Further protective colloids are polyvinyl alcohol, polyvinylpyrrolidone, methylcellulose, carboxymethylcellulose, hydroxypropylcellulose and alginates.

The stability of the aggregates can be positively influenced by the addition of plasticizers. Suitable plasticizers for this purpose are, for example, sugars or sugar alcohols such as sucrose, glucose, lactose, invert sugar, sorbitol, mannitol or glycerol.

The amounts of protective colloid, plasticizer and the compound or compounds (V) or other colorant constituents, in particular other carotenoids, in the colorants are generally chosen such that a final product is obtained which is between 0.1 and 100 ppm, preferably between , 0.5 and 50 ppm, particularly preferably 1 to 20 ppm of the abovementioned compounds, 20 to 200 ppm of a protective colloid, 20 to 200 ppm of a plasticizer and optionally small amounts of a stabilizer. The quantities given refer in each case to the total mass of the colored preparations, dermocosmetics, pharmaceuticals, food and feed or the solids, liquids or mixtures thereof. The colorants can be prepared by simple mixing. The colorant ingredients may be added and mixed sequentially or simultaneously. The proportions of the compounds (V) possibly also in the form of antioxidants, mixtures (M 1) or (M2), preparations, vesicles or carotenoid formulations depends on the desired color effect and the intended use of the colorants according to the invention. According to this, the type and amount of the other colorant constituents also depends. Thus, for colorants according to the invention intended for human or animal use, for example for use in dermocosmetics, pharmaceuticals, foodstuffs and feedstuffs, it is preferred to use colorant ingredients which are suitable and preferred for these uses.

The compounds (V) can be present in different forms depending on the solvent and temperature. In a preferred embodiment, the compounds (V) are present in the colorants in the form of aggregates, preferably H or J aggregates. These aggregates have a higher light stability in comparison with the monomeric forms and are therefore particularly suitable for applications in which the highest possible light stability of the dyeing is to be achieved. The aggregates can be produced, for example, by mixing a solution of one or more of the compounds (V) optionally in admixture with other substances, preferably other carotenoids, in a water-miscible organic solvent, such as isopropanol, ethanol, acetone or tetrahydrofuran, with water , When choosing the appropriate proportions of water and organic solvents either H or J aggregates can be generated. These are characterized by a high light stability. H aggregates show a "card game-like" stacking of the molecules, J aggregates show a linear arrangement of the molecules resembling a head-to-tail linkage, and H aggregates are characterized by a hypsochromically shifted absorbance band in the UV / Vis spectrum, J-aggregates can be detected by a bathocrome shift.These absorption differences can be used to distinguish the aggregates and determine their quantitative ratio.

vesicles

Another object of the present invention are vesicles containing at least one of the compounds (V), preferably 3, 3'-Dihydroxyisorenieratin included. The vesicles may have been prepared using one or more of the compounds (V), mixtures (M1) or (M2) and / or the colorants, preparations or carotenoid formulations of the invention and may be used for the preparation of antioxidants, mixtures (M1 ) or (M2), colorants, preparations, carotenoid formulations, dermocosmetics, pharmaceuticals, foodstuffs or solids and liquids or mixtures thereof.

The type and amount of the compounds (V) used and any other vesicle constituents present depends on the particular intended use of the vesicles. It goes without saying that other requirements apply to vesicles used for food apply to vesicles used for technical dispersions. If the vesicles are used in human or animal applications, for example in dermocosmetics, pharmaceuticals or food and feed, only such other vesicle ingredients as are suitable for human and / or animal consumption or for use in human beings should be used Dermocosmetics or pharmaceuticals.

Substances and mixtures of substances which are suitable as further vesicle constituents are, for example, emulsifiers, dispersants, other carotenoids, further antioxidants, peroxide decomposers, radical decomposers, vitamins or polymers.

The vesicles consist of a hydrophobic sphere in a hydrophilic environment. These spheres may be homogeneous or consist of one or more hydrophobic layers enclosing a hydrophilic core and possibly separated from each other by a hydrophilic layer. The other vesicle constituents may be located in the hydrophobic layer or in the hydrophilic layer or partially in the hydrophobic or hydrophilic layer. Partial means here both partially in relation to the amount as well as the individual molecule of the vesicle component. Vesicle constituents may also be present preferentially or exclusively in one or several specific layers of the vesicles, for example vesicles are possible which contain one or more vesicle constituents only in their hydrophilic interior or in one or more hydrophilic interlayers or in any combination thereof.

The vesicles according to the invention can be prepared in various ways known to the person skilled in the art and using different methods known per se to the person skilled in the art. The compounds (V) can be present in the vesicles as monomers, dimers, trimers, tetramers or in H and J aggregates. The ratio of the respective monomers, dimers, trimers, tetramers or H and / or J-aggregates depends on the particular compound and on other parameters, such as temperature or the composition of the solvent or the lipid phase, and can by influencing these Factors are changed. This allows the ratio of monomer, dimer, trimer, tetramer or the H and J aggregates to the other monomers, dimers, trimers, tetramers or H and J aggregates from 0 wt .-% up to 100 wt .-% , based on the total weight of the respective compound, vary. For example, 3,3'-dihydroxyisorenieratin is present in vesicles of phospholipid layers, preferably in the phospholipid layers, and preferably there in the form of H-aggregates.

One way to make vesicles is to mix one or more of the compounds (V) in a mixture of one or more organic / aprotic solvents with a mixture of lipids in one or more organic / aprotic solvents and then to dry. The resulting film can be overcoated with a buffer solution, sonicated and then extruded. This allows vesicles with different structure and size are produced. The vesicles may consist of one layer (unilamellar vesicles) or of several layers (multilamellar vesicles).

Carotenoid Formulations Another subject of the invention are carotenoid formulations containing one or more of the compounds (V). In addition, the carotenoid formulations contain the ingredients typical of carotenoid formulations, which may vary depending on the application of the carotenoid formulation. The compounds (V) or mixtures thereof may be present in the form of an antioxidant according to the invention, the mixtures (M1) or (M2), preparations according to the invention, colorants or vesicles in the carotenoid formulations or have been used for their use.

The carotenoid formulations according to the invention preferably contain 3,3'-dihydroxyisorenieratin, isorenieratin-3,3'-dichinone and 2,2 ', 4,4'-tetra-tert-butylisorenieratin-3,3'-dichinone, particularly preferably 3, 3'-dihydroxyisorenieratin and 3,3'-dihydroxyisorrenieratin-3-quinone, most preferably 3,3'-dihydroxyisorenieratin. The compounds (V) are preferably used in enriched and particularly preferably in pure form and very particularly preferably in crystalline form for the preparation of the carotenoid formulations according to the invention.

The carotenoid formulations may contain other carotenoid formulation ingredients which are preferably suitable for human or animal consumption. Carotenoid formulation constituents may, for example, be further antioxidants, other carotenoids, preferably natural carotenoids such as β-carotene, lycopene or lutein, astaxanthin, zeaxanthin, cryptoxanthin, α- or β-capsanthin, capsorubin, bixin, vitamins, compounds with Coenzyme character, flavonoids, such as genistein or resveratrol, amino acids, minerals, enzymes, components of garlic, allithiamines, glutathione and its esters, such as GSH monomethyl ester, GSH dimethyl ester, GSH monoethyl ester, GSH diethyl ester or oils, fats or waxes. Among the fats, the fatty acids are advantageous, preferred are unsaturated fatty acids and more preferably polyunsaturated fatty acids, or mixtures thereof. Among the oils, physiologically approved oils are preferred.

Coenzyme compounds are, for example, choline chloride, carnitine, taurine, creatinine, ubiquinone, S-methylmethionine or S-adenosylmethionine.

Components of garlic may be diallyl thiosulfate, S-allyl cysteine sulfoxide, vinyl dithiine, ajoene, allithiamines such as benfotiamine, fursultiamine, octothiamine or bentiamine.

Polyunsaturated fatty acids represent a group within the fats and are, for example, linoleic acid, linolenic acid, arachidonic acid, eicosapentaenoic acid, docusahexaenoic acid. Physiologically-approved oils represent a group within the oils and include oils such as seed oil, corn oil, cottonseed oil, soybean oil, peanut oil, esters of medium chain fatty acids and fish oils such as mackerel, sprat or salmon oil.

The amount of additional carotenoid formulation ingredients in the carotenoid

Formulations is in the range of 0.01 to 40 wt .-%, preferably 0.1 to 30 wt .-%, particularly preferably 0.5 to 20 wt .-%.

Further carotenoid formulation constituents may be, for example, protective colloids, plasticizers, emulsifiers or mixtures of these. The ratio of protective colloid and plasticizer to carotenoid is generally chosen so that a formulation is obtained which, in addition to the above-mentioned carotenoids 10 to 50 wt .-% of a protective colloid, 20 to 70 wt .-% of a plasticizer and optionally subordinate Quantities of a stabilizer, such as another antioxidant contains. The percentages by weight in each case relate to the dry mass of the carotenoid formulation.

The compounds (V) or mixtures thereof may be present in the carotenoid formulations according to the invention as a constituent with a large proportion or with a low proportion. If they are present in high proportions, they can serve, for example, as a cell-protecting dietary supplement; if they are present at low levels, they can, for example, protect the other constituents of the formulation from oxidative reactions. The amount of the individual constituents of the carotenoid formulation according to the invention may vary widely depending on the purpose of the carotenoid formulation. In general, the proportions of the respective constituents are in a range from 0.05 to 100% by weight, based on the total weight of the carotenoid formulation. If β-carotene, lycopene or lutein are in the carotenoid formulation, the proportion of the compounds (V) should in each case be significantly different from the proportion of β-carotene, lycopene or lutein. Significantly different in this case means a proportion of at least 10%, preferably at least 20%, more preferably at least 30% and most preferably at least 40% greater or at least 10%, preferably at least 20%, more preferably at least 30% and most preferably at least 40% smaller than the largest or smallest proportion of the substances ß-carotene, lycopene or lutein.

The carotenoid formulations may be in liquid or solid form. They are preferably in gelatin, particularly preferably in soft gelatin capsules. The preparation of such gelatin or soft gelatin capsules is known to the person skilled in the art or can be carried out by methods known per se to those skilled in the art.

Dermocosmetics Another subject of the invention are dermocosmetics which contain one or more of the compounds (V), antioxidants according to the invention, mixtures (M1) or (M2), preparations, Colorants, vesicles or carotenoid formulations or have been prepared using them.

The dermocosmetics according to the invention can be of different types. Among them, among other skin cosmetic, dermatological or hygienic means of various kinds to understand. Dermocosmetics may include, for example, w / o and o / w skin and body creams, day and night creams, eye creams, sunscreens, after sun products, hand care products, facial creams, multiple emulsions, jellies, microemulsions, liposome preparations, nosome preparations, anti-wrinkle creams, facial oils , Lipogels, sports gels, moisturizing creams, bleaching creams, vitamin creams, skin lotions, body lotions, ampoules, after shave lotions, pre-shaves, moisturizing lotions, tanning lotions, cellulite creams, de-pigmenting agents, massage preparations, body powders, tonic, facial masks, odorants, antiperspirants, nose Trips, anti-acne, repellent, shaving, hair removal, personal care, foot care or baby care products.

The dermocosmetic formulations are preferred in the form of ointments, creams, hydrogels, pastes or patches, as well as liquid dosage forms such as solutions, emulsions, in particular oil-in-water emulsions, suspensions, for example lotions. If desired, liposomes or microspheres may also be used. But they can also be in the form of a solid stick, an aerosol, a spray (pump spray or aerosol),

Foams, gels, gel sprays, lotion, cream, mousse, ointment, suspension or powder or an oily system or a surfactant preparation for the purification of skin and / or hair. Other types of dermocosmetic preparations for cleansing the skin and hair may include, for example, bar soaps, toilet soaps, core soaps, transparent soaps, luxury soaps, de-soaps, cream soaps, baby soaps, skin soaps, abrasive soaps, syndets, liquid soaps, pasty soaps, greases, washing pastes, liquid detergents, Shower and bath preparations, for example washing lotions, shower baths, shower gels, bubble baths, creamed foam baths, oil baths, bath extracts, scrub preparations, in-situ products, shaving foams, shaving lotions or shaving creams. For the purposes of the invention, make-up products in cosmetics, hair dyeing or hair care products, preparations for oral, dental or dental care and perfumes are counted among the dermocosmetics.

The dermocosmetics can be used advantageously for the treatment of cosmetic or dermatological changes of the skin, such as skin aging, the loss of skin moisture, the loss of skin elasticity, the formation of wrinkles, wrinkles or pigmentation disorders or age spots. Furthermore, they can be used to treat or prevent undesired changes in the appearance of the skin, such as acne or oily skin, keratoses, rosaceae or photosensitive, inflammatory, erythematous, allergic or autoimmune reactive reactions and similar alterations. Preferably, the antioxidants or mixtures according to the invention are used in dermocosmetics for rejuvenation and / or revitalization of the skin. However, the dermocosmetics according to the invention also serve to relaxation of sensitive and irritated skin, for the preventive regulation of collagen, hyaluronic acid, elastin synthesis, stimulation of DNA synthesis, especially in deficient or hypoactive skin conditions, regulation of transcription and translation of matrix-degrading enzymes, in particular matrix metalloproteinases (MMPs), increase cell renewal and regeneration of the skin, enhancement of the skin's own protective and repair mechanisms for DNA, lipids and / or proteins. As a result, improvements, for example in the moisture state and / or in the elasticity of the skin, recorded.

The dermocosmetics may further be used for the cleansing of the skin or the hair or both. They are then preferably in liquid or solid form and, in addition to an antioxidant or mixture according to the invention, preferably contain at least one anionic, nonionic or amphoteric surface-active substance or mixtures thereof, if desired one or more electrolytes and auxiliaries as customarily used therefor , The surface-active substance can be present in a concentration of between 1 and 94% by weight in the cleaning preparations, based on the total weight of the preparations.

The dermocosmetics may not be prescription or prescription. Dermatological preparations are usually prescription. Dermatological preparations are understood as medicaments for the therapy or prophylaxis of diseases of the skin (dermatoses). The dermatological preparations can be prepared for the treatment of one or more possibly causally linked disorders, such as anomalies or pathological conditions of the skin. In the preparations according to the invention, individual active ingredients and excipients or combinations of active ingredients and excipients may be present. Particularly suitable are preparations for the treatment of disorders that are due to oxidative processes.

The dermocosmetics according to the invention may contain the dermocosmetic active ingredients and adjuvants conventionally used in such preparations, e.g. As preservatives, bactericides, perfume oils, substances to prevent foaming, dyes, pigments that have a coloring effect, thickeners, moisturizing and / or moisturizing substances, fats, oils, waxes, softeners, surface-active substances, emulsifiers, plasticizing substances or other customary constituents of a dermocosmetic formulation, such as alcohols, polyols, polymers, foam stabilizers, electrolyte, organic solvents, solubilizers, organic acids, or silicone derivatives.

The dermocosmetics may contain, in addition to one or more compounds (V), antioxidants according to the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations and any dermocosmetic agents and excipients present additional substances which have penetration properties and thus a quick one

Allow penetration into the skin. By contrast, for applications with "preconditioning" Character a quick penetration usually unimportant, but the ability to build a depot in the skin, beneficial.

Dermocosmetics may possibly contain at least one other, which is preferably selected among antimycotics, antiseptics, antibiotics, sulfonamides, disinfectants, corticosteroids, shale oil and tar sulfonates, astringents, antihidrotic agents, anti-acne agents, to one or more dermocosmetic agents and excipients which may be present. Psoriasis, seborrhea and itching or keratolytic agents.

To prepare the dermocosmetics according to the invention, the dermocosmetic active ingredients and excipients can be mixed or diluted with a suitable excipient. Excipients may be solid or more or less liquid materials which may serve as a vehicle, carrier or medium for the active ingredient. The addition of further dermocosmetic active ingredients and adjuvants is carried out, if desired, in the manner known to the person skilled in the art.

The dermocosmetics may contain, in addition to the said dermocosmetic agents and excipients, other compounds which are radically decomposing, peroxide-decomposing, anti-inflammatory, anti-inflammatory or anti-allergic, in order to supplement or enhance their action. In particular, these compounds can be selected from the group of vitamins, plant extracts, α- and β-hydroxy acids, ceramides, anti-inflammatory, antimicrobial or UV-filtering substances, ethoxylated oils selected from the group of ethoxylated glycerol fatty acid esters, thickeners, emulsifiers, Surfactants, preservatives, perfume oils, thickeners, hair polymers, hair and skin conditioners, graft polymers, water-soluble or dispersible silicone-containing polymers, polysorbates, light stabilizers, bleaches, gelling agents, conditioners, colorants, tints, tanning agents, dyes, pigments, bodying agents, moisturizers, restoats , Collagen, protein hydrolysates, lipids, antioxidants, defoamers, antistatic agents, emollients and emollients, lubricants, wetting agents, emulsifying and suspending agents, preservatives, anti-irritants, chelating agents, emulsion stabilizers, film-forming agents gellants, odor masking agents, resins, hydrocolloids, solvents, solubilizers, neutralizing agents, permeation enhancers, pigments, quaternary ammonium compounds, refatting and superfatting agents, ointment, cream or oil bases, silicone derivatives, stabilizers, sterilants, blowing agents, drying agents, Opacifiers, thickeners, waxes, plasticizers, white oils. A related embodiment is based on expert knowledge, as shown for example in Fiedler, HP Lexicon of excipients for pharmacy, cosmetics and related fields, 4th ed., Aulendorf: ECV Edition Kantor Verlag, 1996. Furthermore, the active ingredients and adjuvants may be selected from the group of natural or synthetic polymers, pigments, humectants, oils, waxes, enzymes, minerals, dyes, fragrances and derivatives thereof and mixtures thereof. Polysorbates are used according to the invention advantageously in a concentration of 0.1 to 5 wt .-% and in particular in a concentration of 1, 5 to 2.5 wt .-%, based on the total weight of the composition individually or as a mixture of several polysorbates used.

The dermocosmetics may contain, in addition to the antioxidants according to the invention still further antioxidants. The amount of the further antioxidants (one or more compounds) in the dermocosmetics is preferably from 0.001 to 30 wt .-%, particularly preferably from 0.05 to 20 wt .-%, in particular from 1 to 10 wt .-%, based on the total weight of the preparation.

If vitamin E and / or its derivatives represent the further antioxidant (s), it is advantageous to choose their respective concentrations from the range from 0.001 to 10% by weight, based on the total weight of the dermocosmetic preparation. If vitamin A or vitamin A derivatives or other carotenes or their derivatives represent the anti-oxidant (s), it is advantageous if their respective concentrations are in the range from 0.001 to 10% by weight, based on the total weight of the Dermocosmetic, to choose.

In one embodiment, the use of the antioxidants according to the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations or the antioxidants prepared according to the inventive method, mixtures (M1) or (M2), preparations, colorants , Vesicles or carotenoid formulations having at least one particulate matter present in the composition in a proportion of from 0.01 to 10, preferably from 0.05 to 5,% by weight. Suitable substances are, for example, substances which are solid at room temperature (25 ° C.) and in the form of particles. Suitable examples are silica, silicates, aluminates, clays, mica, salts, in particular inorganic metal salts, metal oxides, for example titanium dioxide, minerals and polymer particles. The particles are present in the composition in undissolved and preferably stably dispersed form and can deposit in solid form after application to the surface of the application and evaporation of the solvent. Preferred particulate substances are silica (silica gel, silica) and metal salts, in particular inorganic metal salts, with silica being particularly preferred. Metal salts are, for example, alkali or alkaline earth halides such as sodium chloride or potassium chloride or alkali or alkaline earth sulfates such as sodium sulfate or magnesium sulfate. The dermocosmetics may contain a lipid phase and an aqueous phase.

The lipid phase can advantageously be chosen from the following substance group: mineral oils, mineral waxes, oils, such as triglycerides of capric or caprylic acid, but preferably ricinus oil, fats, waxes and other natural and synthetic fatty substances, preferably esters of fatty acids with alcohols of lower C Number, for example with isopropanol, propylene glycol or glycerol, or esters of fatty alcohols with alkanoic acids of low C number or with fatty acids; Alkylbenzoates, silicone oils such as dimethylpolysiloxanes, diethylpolysiloxanes, diphenylpolysiloxanes and mixed forms thereof.

The oil phase of emulsions, oleogels or hydrodispersions or lipodispersions can advantageously be selected from the group of esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids having a chain length of 3 to 30 carbon atoms, from the group of esters of aromatic Carboxylic acids and saturated and / or unsaturated, branched and / or unbranched alcohols of a chain length of 3 to 30 carbon atoms. Preference is given to ester oils from the group consisting of isopropyl myristate, isopropyl palmitate, isopropyl stearate, isopropyl oleate, n-butyl stereate, n-hexyl laurate, n-decyl oleate, isooctyl stearate, isononyl stearate, isononyl isoanoate, 2-ethylhexyl palmitate, 2-ethylhexyl laurate, 2-hexyldecyl stearate, 2-octyldodecyl palmitate, oleyl oleate, Oleyl erucate, erucyl oleate, erucyl erucate and synthetic, semi-synthetic and natural mixtures of such esters, for example jojoba oil.

Furthermore, the oil phase can advantageously be selected from the group of branched and unbranched hydrocarbons and waxes, silicone oils, dialkyl ethers, the group of saturated or unsaturated, branched or unbranched alcohols, and fatty acid triglycerides, namely the triglycerol esters of saturated and / or unsaturated, branched and / or unbranched alkanecarboxylic acids of a chain length of 8 to 24, in particular 12 to 18 carbon atoms. The fatty acid triglycerides can be selected, for example, advantageously from the group of synthetic, semisynthetic and natural oils, such as olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil.

Any mixtures of such oil and wax components are also advantageous to use in the context of the present invention. It may also be advantageous, if appropriate, to use waxes, for example cetyl palmitate, as the sole lipid component of the oil phase.

Advantageously, the oil phase is selected from the group consisting of 2-ethylhexyl isostearate, octyldodecanol, isotridecyl isononanoate, isoeicosane, 2-ethylhexyl cocoate, C 12 -cis-alkyl benzoate, caprylic capric acid triglyceride, dicapryl ether.

Particularly advantageous are mixtures of C 12 -C 18 -alkyl benzoate, 2-ethylhexyl isostearate and isotridecyl isononanoate. Of the hydrocarbons, paraffin oil, squalane and squalene are to be used advantageously in the context of the present invention.

Advantageously, the oil phase may further comprise a content of cyclic or linear silicone oils or consist entirely of such oils, although it is preferred to use an additional content of other oil phase components in addition to the silicone oil or silicone oils.

Advantageously, cyclomethicone (octamethylcyclotetrasiloxane) is used as the silicone oil to be used according to the invention. However, other silicone oils are also advantageous for the purposes of the present invention, for example hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).

Also particularly advantageous are mixtures of cyclomethicone and Isotridecylisonnanoat from cyclomethicone and 2-Ethylhexylisostearat.

If desired, the aqueous phase of the dermocosmetics according to the invention advantageously contains alcohols, diols or polyols of low C number, and their ethers, preferably ethanol, isopropanol, propylene glycol, glycerol, ethylene glycol, ethylene glycol monoethyl or monobutyl ether, propylene glycol monomethyl, monoethyl or monobutyl ether Diethylene glycol monomethyl or monoethyl ether and analogous products and in particular one or more thickeners, which may be advantageously selected from the group of silica, aluminum silicates, polysaccharides or their derivatives, for example hyaluronic acid, xanthan gum, hydroxypropylmethylcellulose, particularly advantageous from Group of polyacrylates, preferably a polyacrylate from the group of so-called Carbopols, for example Carbopols types 980, 981, 1382, 2984, 5984, each individually or in combination.

The active ingredients and auxiliaries can also be described in encapsulated form as described in the patents or patent applications EP 00974775 B1, DE 23 1 1 712, EP 02 78 878, DE 19 99 47 147, EP 0706822 B1 and WO 98/16621, whereupon is hereby incorporated by reference, be included in the preparations of the invention.

If desired, several dermocosmetic active ingredients and adjuvants can be formulated together. However, they can also initially be processed separately and then merged.

The formulation base of dermocosmetics according to the invention preferably contains one or more cosmetically acceptable media, cosmetically acceptable substances and possibly pharmaceutically acceptable active substances and adjuvants. Pharmaceutically acceptable are those known in the pharmaceutical, food technology and related fields. Usable active ingredients and excipients, in particular those listed in relevant pharmacopoeias (for example, in DAB Ph. Eur. BP NF) and other active ingredients and adjuvants whose properties do not interfere with a physiological application.

The dermocosmetics may preferably be used in individuals, preferably mammals, especially humans, farm animals or domestic animals. They are applied in a customary manner for the respective preparation. Dermocosmetics are usually used in a sufficiently effective amount and preferably transdermally (topically).

According to a preferred embodiment, the application according to the invention of the dermocosmetics takes place by regular application over a period of time. This depends on the desired goal, d. H. the period of time may extend over the lifetime of the user, preferably over a period of time of up to three months, and more preferably over one week to two months, when the goal is to build a depot in the skin. For an after-sun application is considered as the application period in the context of the invention, the single application, but preferably a period of at least one day, more preferably over three days to three months, more preferably over one to two weeks.

The antioxidants or mixtures (M1) or (M2) according to the invention, preparations, colorants, vesicles or carotenoid formulations can, on the one hand, reduce damage, for example to the skin or hair as a result of endogenous or exogenous oxidative processes, and, on the other hand contribute to the protection of substances sensitive to oxidation and thus to the stabilization of the respective preparation.

Stabilization here is a comparison to preparations without inventive

Concentrations of antioxidant according to the invention or mixtures, colorants, vesicles or carotenoid formulations, with otherwise identical composition and the same load longer usability of the preparations or a prevention or reduction of spoilage or inactivation of the light and / or oxidation sensitive dermocosmetic agents or other or other Ingredients of dermocosmetic, as a result of, for example, light-induced oxidation damage.

The dermocosmetics according to the invention generally contain from 0.01 to 30% by weight, preferably from 0.01% by weight to 15% by weight, particularly preferably from 0.05 to 5% by weight, very particularly preferably from 0 , 1 to 2 wt.% Of the antioxidant of the invention, the mixtures (M1) or (M2), preparation, colorants, vesicles or carotenoid formulations, based on the total weight of the dermocosmetic.

Optionally, the antioxidant (s) of the invention, mixtures (M 1) or (M2), preparations, colorants, vesicles or carotenoid formulations with further active ingredients and excipients in encapsulated form is used, for example as cellulose encapsulation, in Gelatin, with polyamides, in niosomes, wax matrices, encapsulated with cyclodextrins or liposomal.

Furthermore, the invention relates to the use of the abovementioned antioxidants according to the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations or the antioxidants prepared according to the method of the invention, mixtures (M1) or (M2), Preparations, colorants, vesicles or carotenoid formulations in dermocosmetics. Preference is given to the antioxidants according to the invention, mixtures, colorants, vesicles or carotenoid formulations or the antioxidants, mixtures, colorants, vesicles or carotenoid formulations prepared according to the process according to the invention in combination with (i) cosmetic aids from the field of decorative cosmetics, ii) the dermocosmetic agents and (iii) suitable excipients and additives. These are preferably active substances or auxiliaries and additives which protect skin, hair and / or fingernails or toenails from damage, for the treatment of already occurring damage to the skin, hair and / or fingernails or toenails and Care of skin, hair and / or fingernails or toenails are used. These active substances are preferably selected from the group of natural or synthetic polymers, pigments, humectants, oils, waxes, enzymes, minerals, vitamins, sunscreens, dyes, fragrances, antioxidants, preservatives and / or pharmaceutical active ingredients.

The use of the abovementioned antioxidants according to the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations or the antioxidants prepared according to the method according to the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or Carotenoid formulations are preferably in skin protection agents, skin care products, skin cleansers, hair protection agents, hair care products, hair cleansers, hair dyes, or preparations for decorative cosmetics, depending on the field of application preferably in the form of ointments, creams, emulsions, suspensions, lotions, as milk, pastes, Gels, foams or sprays are applied.

Suitable auxiliaries and additives for the production of hair cosmetic or skin cosmetic preparations are familiar to the expert and can from manuals of cosmetics, such as Schrader, bases and formulations of cosmetics, Hüthig Verlag, Heidberg, 1989, ISBN 3-7785-1491-1 , or Limbach, cosmetics: development, production and use of ksometischer means, 2nd extended edition, 1995, Georg Thieme Verlag, ISBN 3 13 712 602 9 are removed.

The use of the antioxidants according to the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations or the antioxidants prepared according to the method according to the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations in dermocosmetics in combination with at least one different constituent selected from cosmetically active ingredients, emulsifiers, surfactants, preservatives, perfume oils, thickeners, hair polymers, hair and skin conditioners, graft polymers, water-soluble or dispersible silicone-containing polymers, pharmaceutically acceptable polymers, sunscreens, Bleaching agents, gelling agents, conditioners, colorants, tinting agents, tanning agents, dyes, pigments, bodying agents, moisturizers, re-fats, collagen, protein hydrolysates, lipids, antioxidants, defoamers, antistatics, emollients and plasticizers.

Also according to the invention is the use of the antioxidants according to the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations or the antioxidants prepared according to the method of the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations in combination with sunscreens in dermocosmetics. These dermocemetic sunscreen compositions are used for cosmetic and / or dermatological photoprotection, furthermore for the treatment and care of the skin and / or the hair and as a make-up product in decorative cosmetics. These include, for example, sunscreens, lotions, milks, oils, baisams, gels, lip care and lipsticks, masking creams and sticks, moisturizers, lotions, emulsions, face, body and hand creams, hair conditioners and rinses. Hair fixatives, styling gels, hair sprays, deodorants or eye-wrinkle creams, tro- picals, sunblocks or aftersun preparations.

Sun oils are usually mixtures of various oils with one or more sunscreen filters and perfume oils. The oil components are selected according to different cosmetic properties. Oils that provide good fat and soft feel, such as mineral oils such as paraffin oils, and fatty acid triglycerides, such as peanut oil, sesame oil, avocado oil, medium chain triglycerides, are mixed with oils that improve the dispersibility and wicking of the sun oils into the skin, reduce the stickiness and make the oil film permeable to air and water vapor (perspiration). These include branched-chain fatty acid esters (for example isopropyl palmitate) and silicone oils (for example dimethylsilicone). When unsaturated fatty acid-based oils are used, the present or other antioxidants, such as tocopherol, are added to prevent rancidity. Sun oils as anhydrous formulations usually contain no preservatives. Sunmilk and creams are made as oil-in-water (O / W) emulsions and as water-in-oil (W / O) emulsions. Depending on the type of emulsion, the properties of the preparations are very different: O / W emulsions are easily distributed on the skin, they are usually absorbed quickly and are almost always readily washable with water. W / O emulsions are harder to rub in, they make the skin stronger and thus look a bit stickier, but on the other hand they better protect the skin from drying out. W / O emulsions are mostly waterproof. In the case of O / W emulsions, the emulsion base, the selection of suitable light stabilizers and, if appropriate, the use of auxiliaries (eg polymers) determine the degree of water resistance. The basis of liquid and creamy O / W-Ernulsionen resemble in their composition the Other usual in skin care emulsions. Sunscreen should sufficiently grease the skin dried up by sun, water and wind. It must not be sticky, as it is particularly uncomfortable in the heat and in contact with sand. The light stabilizers are usually built up on the basis of a carrier which contains at least one oil phase. However, compositions based on water are also possible. Accordingly, oils, oil-in-water and water-in-oil emulsions, creams and pastes, lip protection pen masses or fat-free gels are possible. Other suitable emulsions include O / W macroemulsions, O / W microemulsions or O / W / O emulsions having surface-coated titanium dioxide particles in dispersed form, the emulsions being prepared by phase inversion technology, according to DE-A-197 26 121 are available.

Typical cosmetic auxiliaries which can be considered as additives are, for example, (co-) emulsifiers, fats and waxes, stabilizers, thickeners, biogenic active ingredients, film formers, fragrances, dyes, pearlescing agents, preservatives, pigments, electrolyte (eg. Magnesium sulfate) and pH regulators. As stabilizers metal salts of fatty acids such as. As magnesium, aluminum and / or zinc stearate. Biogenic active ingredients are understood as meaning, for example, plant extracts, protein hydrolysates and vitamin complexes. Typical film formers are, for example, hydrocolloids such as chitosan, microcrystalline chitosan or quaternized chitosan, polyvinylpyrrolidone, vinylpyrrolidone-vinyl acetate copolymers, polymers of the acrylic acid series, quaternary cellulose derivatives and similar compounds.

Suitable light filter active substances are substances which absorb UV rays in the UV-B and / or UV-A range. These are organic substances which are able to absorb ultraviolet rays and to release the absorbed energy in the form of longer-wave radiation, for example in the form of heat. The organic substances may be oil-soluble or water-soluble. Suitable UV filters are, for example, 2,4,6-triaryl-1,3,5-triazines, in which the aryl groups can each carry at least one substituent, which is preferably selected from hydroxy, alkoxy, especially methoxy, alkoxycarbonyl, especially methoxycarbonyl and ethoxycarbonyl. Also suitable are p-aminobenzoic acid esters, cinnamic acid esters, benzophenones, camphor derivatives and UV-radiation-stopping pigments, such as titanium dioxide, talc and zinc oxide. Particular preference is given to pigments based on titanium dioxide.

For example, the following substances can be used as oil-soluble UV-B filters: 3-benzylidene camphor and its derivatives, for example 3- (4-methylbenzylidene) camphor; A-aminobenzoic acid derivatives, preferably 2-ethylhexyl 4- (dimethylamino) benzoate, 2-octyl A- (dimethylamino) benzoate and 4- (dimethylamino) benzoic acid ester;

Esters of cinnamic acid, preferably 4-methoxycinnamic acid 2-ethylhexyl ester, 4-methoxycinnamic acid propyl ester, isoamyl 4-methoxycinnamate, 4-isopentyl methoxycinnamate, 2-cyano-3-phenylcinnamic acid 2-ethylhexyl ester (octocrylene); Esters of salicylic acid, preferably 2-ethylhexyl salicylate, 4-isopropylbenzyl salicylate, homomenthyl salicylate;

Derivatives of benzophenone, preferably 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone;

Esters of benzalmalonic acid, preferably di-2-ethylhexyl 4-methoxybenzmalonate;

Triazine derivatives, such as. For example, 2,4,6-trianilino- (p-carbo-2'-ethyl-1 ^'-hexyloxy) -1, 3,5-triazine (Octyltria- zone) and Dioctyl Butamido Triazone (Uvasorb HEB ^®):

Propane-1, 3-dione, such as. B. 1 - (4-tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1,3-dione.

Suitable water-soluble substances are:

2-phenylbenzimidazole-5-sulfonic acid and its alkali, alkaline earth, ammonium, alkylammonium, alkanolammonium and glucammonium salts;

Sulfonic acid derivatives of benzophenones, preferably 2-hydroxy-4-methoxybenzo-phenone-5-sulfonic acid and its salts;

Sulfonic acid derivatives of 3-Benzylidencamphers, such as. B. 4- (2-oxo-3-bornylidenemethyl) benzenesulfonic acid and 2-methyl-5- (2-oxo-3-bomylidene) sulfonic acid and salts thereof.

Especially preferred is the use of esters of cinnamic acid, preferably 4-methoxycinnamic acid 2-ethylhexyl ester, 4-methoxycinnamic acid isopentyl ester, 2-cyano-3-phenylcinnamic acid 2-ethylhexyl ester (octocrylene).

Furthermore, the use of derivatives of benzophenone, in particular 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone and the use of propane-1, 3-diones, such as 1- (4-tert-butylphenyl) -3- (4-methoxyphenyl) propane-1,3-dione.

Typical UV-A filters are:

Derivatives of benzoylmethane, such as 1- (4'-tert-butylphenyl) -3- (4'-methoxyphenyl) propane-1,3-dione, 4-tert. Butyl 4'-methoxydibenzoylmethane or 1-phenyl-3- (4'-isopropylphenyl) propane-1,3-dione;

Amino-hydroxy-substituted derivatives of benzophenones such as N, N-diethylamino-hydroxybenzoyl-n-hexylbenzoate. Of course, the UV-A and UV-B filters can also be used in combinations.

Further suitable UV filter substances are mentioned in the following table.

Table 4: suitable sunscreens

In addition to the two aforementioned groups of primary light stabilizers, it is also possible to use secondary light stabilizers of the antioxidant type which interrupt the photochemical reaction chain which is triggered when UV radiation penetrates into the skin. Typical examples of these are superoxide dismutase, catalase, tocopherols (vitamin E) and ascorbic acid (vitamin C).

Another group are anti-irritants, which have an anti-inflammatory effect on UV-damaged skin. Such substances are, for example, bisabolol, phytol and phytantriol.

Also according to the invention is the use of the antioxidants, mixtures, colorants, vesicles or carotenoid formulations according to the invention or the antioxidants, mixtures, colorants, vesicles or carotenoid formulations prepared in accordance with the process according to the invention in combination with UV-blocking inorganic pigments in dermocosmetics. Preference is given to pigments based on metal oxides and / or other sparingly water-soluble or insoluble metal compounds selected from the group of the oxides of zinc (ZnO), titanium (TiO.sub.2), iron (eg Fe.sub.2O.sub.3), zirconium (ZrO.sub.2), silicon ( Si02), manganese (eg MnO), aluminum (Al2O3), cerium (like Cβ2θ3), mixed oxides of the corresponding metals and mixtures of such oxides.

The inorganic pigments can be present in coated form, ie they are treated on the surface. This surface treatment may be, for example, that the pigments are provided in a manner known per se, as described in DE-A-33 14 742, with a thin hydrophobic layer.

Furthermore, the abovementioned dermocosmetics preferably contain so-called peroxide diesters, which are compounds which are able to decompose peroxides, particularly preferably lipid peroxides. These include organic substances, such as. For example, pyridine-2-thiol-3-carboxylic acid, 2-methoxy-pyrimidinol-carboxylic acids, 2-methoxy-pyridinecarboxylic acids, 2-dimethylamino-pyrimidinolcarbonsäuren, 2-dimethylamino-pyridinecarboxylic acids.

The amount of the mocosmetic active ingredients (one or more compounds) in the preparations according to the invention is preferably 0.001 to 30 wt .-%, particularly preferably 0.05 to 20 wt .-%, in particular 1 to 10 wt .-%, based on the Total weight of the preparation. The above-mentioned and other active substances which can be used in the preparations according to the invention are specified in DE 103 18 526 A1 on pages 12 to 17, to which reference is made at this point in its entirety.

In a preferred embodiment of the present invention, the dermocosmetics, preferably the skin and hair treatment agents, the antioxidants according to the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations or the antioxidants prepared according to the inventive method , Mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations in a concentration of 0.001 to 1 wt .-%, preferably from 0.01 to 0.9 wt .-%, particularly preferably of 0.01 to 0.8 wt .-% or from 0.01 to 0.7 wt .-%, most preferably from 0.01 to 0.6 wt .-% or from 0.01 to 0.5 wt %, most preferably from 0.01 to 0.4% by weight or from 0.01 to 0.3% by weight, based on the total weight of the dermocosmetic. In a further embodiment, the dermocosmetics contain the antioxidants according to the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations or the antioxidants prepared according to the method according to the invention, mixtures (M1) or (M2), preparations, colorants , Vesicle or carotenoid formulations in a concentration of 1 to 10% by weight, preferably from 2 to 8 wt .-%, from 3 to 7 wt .-%, of 4 to 6 wt .-% based on the total weight of Dermokosmetikums. In a likewise preferred embodiment, the dermocosmetics contain the antioxidants according to the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations or the antioxidants prepared according to the method of the invention, mixtures, colorants, vesicles or carotenoid formulations in one Concentration of 10 to 20 wt .-%, preferably from 1 1 to 19 wt .-%, from 12 to 18 wt .-%, from 13 to 17 wt .-%, of 14 to 16 wt .-% based on the Total weight of dermocosmetic. In a likewise preferred embodiment, the dermocosmetics contain the antioxidants according to the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations or the antioxidants prepared according to the method of the invention, mixtures (M1) or (M2), preparations, Colorants, vesicles or carotid noid formulations in a concentration of from 20 to 30% by weight, preferably from 21 to 29% by weight, from 22 to 28% by weight, from 23 to 27% by weight, from 24 to 26% by weight. % based on the total weight of the dermocosmetic.

In addition, the following applies to the dermocosmetics according to the invention:

The formulation base of dermocosmetics according to the invention preferably contains dermoscopically or pharmaceutically acceptable active substances or adjuvants. Pharmaceutically acceptable excipients which are known to be useful in the pharmaceutical, food technology and related fields, in particular those listed in relevant pharmacopoeias (such as DAB Ph. Eur. BP NF) and other excipients whose properties do not preclude physiological application.

Suitable dermocosmetic or pharmaceutical auxiliaries may be: lubricants, wetting agents, emulsifying and suspending agents, preserving agents, antioxidants, anti-irritants, chelating agents, emulsion stabilizers, film formers, gelling agents, odor masking agents, resins, hydrocolloids, solvents, solubilizers, neutralizing agents, permeation accelerators, Pigments, quaternary ammonium compounds, refatting and superfatting agents, ointment, cream or oil bases, silicone derivatives, stabilizers, sterilants, blowing agents, drying agents, opacifiers, thickeners, waxes, plasticizers, white oil. A related embodiment is based on expert knowledge, as shown for example in Fiedler, H. P. Lexicon of excipients for pharmacy, cosmetics and related fields, 4th ed., Aulendorf: ECV Editio Kantor Verlag, 1996.

To produce the dermocosmetics according to the invention, the active ingredients can be mixed or diluted with a suitable excipient (excipient). Excipients may be solid, semi-solid or liquid materials which may serve as a vehicle, carrier or medium for the active ingredient. If desired, the admixing of further auxiliaries takes place in the manner known to the person skilled in the art. Furthermore, the polymers and dispersions are suitable as auxiliaries in pharmacy, preferably as or in coating agent (s) or binder (s) for solid dosage forms. They can also be used in creams and as tablet coatings and tablet binders.

According to a further preferred embodiment, the dermocosmetics according to the invention are cosmetic preparations for the care and protection of the skin and hair, nail conditioners or preparations for decorative cosmetics.

Suitable dermocosmetics are, for example, face lotions, face masks, deodorants and other cosmetic lotions. Means for use in decorative cosmetics include, for example, masking pens, theatrical paints, mascara and eye shadows, lipsticks, kohl pencils, eyeliners, rouges, powders, and eyebrow pencils. In addition, the O / W dispersions can be used in nasal strips for pore cleansing, anti-acne agents, repellents, shaving agents, after- and pre-shave care products, after-sun care products, hair removal products, hair dyes, personal care products, foot care products and baby care.

The skin cosmetic preparations may contain, in addition to the abovementioned compounds of the invention and suitable carriers, other active ingredients and adjuvants customary in skin cosmetics, as described above. These preferably include emulsifiers, preservatives, perfume oils, cosmetic active ingredients such as phytantriol, bisabolol, panthenol, light stabilizers, bleaching agents, colorants, tinting agents, tanning agents, collagen, protein hydrolysates, stabilizers, pH regulators, dyes, salts, thickeners, Gel formers, bodying agents, silicones, humectants, moisturizers and / or other common additives.

Preferred oil and fat components of dermocosmetics are the aforementioned mineral and synthetic oils, such as paraffins, silicone oils and aliphatic hydrocarbons having more than 8 carbon atoms, animal and vegetable oils, such as. Sunflower oil, coconut oil, avocado oil, olive oil, lanolin or waxes, fatty acids, fatty acid esters, such as. Triglycerides of C6-C30 fatty acids, wax esters such as jojoba oil, fatty alcohols, petrolatum, hydrogenated lanolin and acetylated lanolin, and mixtures thereof.

To set certain properties such. B. improving the feeling of touch, the spreading behavior, the water resistance and / or the binding of active ingredients and excipients, such as pigments, the dermocosmetics may additionally contain conditioning substances based on silicone compounds.

Suitable silicone compounds are, for example, polyalkylsiloxanes, polyarylsiloxanes, polyarylalkylsiloxanes, polyethersiloxanes or silicone resins.

The dermocosmetics are prepared by the customary methods known to the person skilled in the art.

The skin-cosmetic dermocosmetics are preferably present in the form of emulsions, in particular as water-in-oil (W / O) or oil-in-water (O / W) emulsions.

However, it is also possible to choose other types of formulations, for example gels, oils, oleogels, multiple emulsions, for example in the form of W / O / W or O / W / O emulsions, anhydrous ointments or ointment bases, etc. Emulsifier-free formulations such as hydrodispersions, hydrogels or a Pickering emulsion are advantageous embodiments.

Emulsions are prepared by known methods. The emulsions usually contain usual constituents, such as fatty alcohols, fatty acid esters and especially fatty acid triglycerides, fatty acids, lanolin and derivatives thereof, natural or synthetic oils or Waxes and emulsifiers in the presence of water. The selection of the emulsion type-specific additives and the preparation of suitable emulsions is described for example in Schrader, bases and formulations of cosmetics, Hüthig book publishing house, Heidelberg, 2nd edition, 1989, third part, or Limbach, cosmetics: development, production and application of cosmetic Mittel, 2nd extended edition, 1995, Georg Thieme Verlag, ISBN 3 13 712602 9, pages 122 ff., To which reference is hereby expressly made.

Preferred fats and oils which may be included in the fat phase of the emulsions are: hydrocarbon oils such as paraffin oil, purcellin oil, perhydrosqualene and solutions of microcrystalline waxes in these oils; animal or vegetable oils, such as sweet almond oil, avocado oil, calophylum, lanolin and derivatives thereof, castor oil, sesame oil, olive oil, jojoba oil, karite oil, hoplostethus oil, mineral oils, their distillation start point at atmospheric pressure is about 250 ⁰ C and their Distillation end point at 410 ⁰ C is such. As Vaselineöl, esters of saturated or unsaturated fatty acids, such as alkyl myristates, z. For example, i-propyl, butyl or cetyl myristate, hexadecyl stearate, ethyl or i-propyl palmitate, octanoic or Decansäuretriglyceride and Cetylricinololeat.

The fat phase may also contain silicone oils which are soluble in other oils, such as dimethylpolysiloxane, methylphenylpolysiloxane, silicone glycol copolymer, fatty acids and fatty alcohols.

In addition to the compounds of the invention described above, the dermocosmetics may also contain waxes, such as. Carnauba wax, candililla wax, beeswax, microcrystalline wax, ozokerite wax and Ca, Mg and Al oleates, myristates, linoleates and stearates.

According to a further preferred embodiment, the dermocosmetics according to the invention are a light stabilizer, a shower gel, a shampoo formulation or a bath preparation, sunscreen preparations being particularly preferred.

In addition to the antioxidants according to the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations or the antioxidants, mixtures, colorants, vesicles or carotenoid formulations prepared according to the inventive method, such formulations usually contain anionic surfactants as base surfactants and amphoteric and / or nonionic surfactants as cosurfactants. Other suitable active ingredients and / or adjuvants are generally selected from lipids, perfume oils, dyes, organic acids, preservatives and antioxidants and thickeners / gelling agents, skin conditioners and moisturizers.

These formulations preferably contain from 2 to 50% by weight, preferably from 5 to 40% by weight, more preferably from 8 to 30% by weight of surfactants, based on the total weight of the formulation. In the washing, shower and bath preparations all anionic, neutral, amphoteric or cationic surfactants commonly used in personal care products can be used.

Suitable anionic surfactants are, for example, alkyl sulfates, alkyl ether sulfates, alkyl sulfonates, alkylaryl sulfonates, alkyl succinates, alkyl sulfosuccinates, N-alkoyl sarcosinates, acyl taurates, acyl isothionates, alkyl phosphates, alkyl ether phosphates, alkyl ether carboxylates, alpha-olefin sulfonates, in particular the alkali metal and alkaline earth metal salts, eg. As sodium, potassium, magnesium, calcium, and ammonium and triethanolamine salts. The alkyl ether sulfates, alkyl ether phosphates and alkyl ether carboxylates can have from 1 to 10 ethylene oxide or propylene oxide units, preferably from 1 to 3 ethylene oxide units in the molecule.

These include z. Sodium lauryl sulfate, ammonium tauryl sulfate, sodium lauryl ether sulfate, ammonium lauryl ether sulfate, sodium lauryl sarcosinate, sodium oleyl succinate, ammonium lauryl sulfosuccinate, sodium dodecyl benzene sulfonate, triethanolamine dodecylbenzene sulfonate.

Suitable amphoteric surfactants are, for. As alkyl betaines, Alkylamidopropylbetaine, Alkylsulfobetai- ne, alkyl glycinates, alkylcarboxyglycinates, alkylamphoacetates or propionates, alkylamphodiacetates or dipropionates.

For example, cocodimethylsulfopropyl betaine, lauryl betaine, cocamidopropyl betaine or sodium cocamphopropionate can be used.

Suitable nonionic surfactants are, for example, the reaction products of aliphatic alcohols or alkylphenols having 6 to 20 C atoms in the alkyl chain, which may be linear or branched, with ethylene oxide and / or propylene oxide. The amount of alkylene oxide is about 6 to 60 moles per mole of alcohol. Also suitable are alkylamine oxides, mono- or dialkylalkanolamides, fatty acid esters of polyethylene glycols, ethoxylated fatty acid amides, alkylpolyglycosides or sorbitan ether esters.

In addition, the washing, showering and bathing preparations may contain conventional cationic surfactants, such as. For example, quaternary ammonium compounds, for example Cetyltrimethylammoniumch- lorid.

Furthermore, the shower gel / shampoo formulations thickener, such. For example, common salt, PEG-55, propylene glycol oleate, PEG-120-Methylglucose dioleate and others as well as preservatives, other active ingredients and excipients and water.

Furthermore, antioxidants according to the invention, mixtures (M 1) or (M2), preparations, colorants, vesicles or carotenoid formulations in hair cosmetic preparations provide protection against premature aging processes of the human hair and can thus For example, be used as active ingredients in the cosmetic treatment of brittle, dull and inelastic hair.

Dermocosmetics for protecting the hair according to the invention are, for example, shampooing agents, dermocosmetics which are used before or after shampooing, before or after the perming treatment, before or after dyeing or discoloring the hair Dermocosmetics for blow drying or inserting hair, dermocosmetics for dyeing or decolorizing, a hairdressing and treatment lotion, a hair lacquer or permanent waving agent.

Suitable auxiliaries and additives for the production of dermocosmetics to protect the hair are familiar to the expert and can be found in manuals of cosmetics, such as Schrader, bases and formulations of cosmetics, Hüthig Verlag, Heidelberg, 1989, ISBN 3-7785-1491-1, or Limbach, cosmetics: development, production and application of cos- metic agents, 2nd extended edition, 1995, Georg Thieme Verlag, ISBN 3 13 712602 9 be removed.

The dermocosmetics for protecting the hair contain active ingredients and adjuvants, as are commonly used for this type of dermocosmetics for hair care and hair treatment. As active ingredients and adjuvants are, for example, preservatives, surface-active substances, substances for preventing foaming, thickeners, emulsifiers, fats, oils, waxes, organic solvents, bactericides, perfume oils, dyes or pigments, whose job is the hair or the cosmetic and Dermatological preparations to protect the hair itself to dye, electrolytes or substances against the greasing of the hair.

Electrolytes in the context of the present invention are water-soluble alkali, ammonium, alkaline earth (including magnesium) and zinc salts of inorganic anions and any mixtures of such salts to understand that it must be ensured that these salts by pharmaceutical or cosmetic safety distinguished.

The anions according to the invention are preferably selected from the group of the chlorides, the sulfates and hydrogen sulfates, the phosphates. Hydrogen phosphates and the linear and cyclic oligophosphates and the carbonates and bicarbonates.

Are the dermocosmetics to protect the hair in the form of a lotion that rinsed and z. B. before or after decolorization, before or after shampooing, between two Shampoonierungsschritten before or after the permanent wave treatment is applied, so it is z. B. aqueous or aqueous-alcoholic solutions containing optionally surface-active substances whose concentration in the range of 0.1 and 10% by weight, preferably from 0.2 and 5 wt .-%, based on the total weight of the preparation, can lie. A dermocosmetic preparation for protecting the hair in the form of a lotion that is not rinsed, in particular a lotion for inserting the hair, a lotion used to blow-dry the hair or a hairdressing and treatment lotion, generally constitutes an aqueous, alcoholic or aqueous-alcoholic solution and contains at least one cationic, anionic, nonionic or amphoteric polymer or mixtures thereof and / or at least one lignan selected from the group consisting of Secoisola- riciresinol, matairesinol, enterolactone, enterodiol, pinoresinol, syringaresinol , Isolaririciresinol and Lariciresinol and their glycosides in effective concentration. The amount of the polymers used is for example in the range of 0.1 and 10 wt .-%, preferably from 0.1 and 3 wt .-%, based on the total weight of the preparation.

Dermocosmetics for protecting the hair containing antioxidants according to the invention may be present as emulsions which are of the non-ionic or anionic type. In addition to water, nonionic emulsions contain oils or fatty alcohols which may, for example, also be polyethoxylated or polypropoxylated, or else mixtures of the two organic components. These emulsions optionally contain cationic surfactants.

According to the invention, dermocosmetics for protecting hair may be present as gels which, in addition to an effective content of at least one of the compounds (V) or the antioxidants, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations, preferably water, organic thickeners, e.g. Gum arabic, xanthan gum, sodium alginate, cellulose derivatives, preferably methyl cellulose, hydroxy methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose or inorganic thickening agents, e.g. For example, aluminum silicates such as bentonites, o- a mixture of polyethylene glycol and polyethylene glycol stearate or distearate. The thickening agent is contained in the gel, for example, in an amount ranging from 0.1 to 30% by weight, preferably from 0.5 to 15% by weight.

Dermocosmetics for protecting the hair, which constitute a shampoo, preferably contain at least one anionic, nonionic or amphoteric surface-active substance or mixture thereof, optionally an electrolyte according to the invention and auxiliaries, as they are usually used for this, in addition to an effective content of antioxidants according to the invention , The surfactant may be present in a concentration ranging from 1% to 94% by weight in the shampoo.

Dermocosmetics according to the invention may also be aqueous dermocosmetics which are detergents or low-water or anhydrous cleansing concentrates intended for aqueous cleaning, may contain anionic, nonionic and / or amphoteric surfactants, for example: conventional soaps, e.g. Fatty acid salts of sodium, alkyl sulfates, alkyl ether sulfates, alkane and alkylbenzenesulfonates, sulfoacetates, sulfobetaines, sarcosyl nate, amidosulfobetaines, sulfosuccinates, sulfosuccinic monoesters, alkyl ether carboxylates, protein-fatty acid condensates, alkyl betaines and amidobetaines, fatty acid alkanolamides, polyglycol ether derivatives.

The dermocosmetics according to the invention are preferably in the form of a mousse, hair mousse, hair gel, shampoos, hair sprays, hair mousse, top fluid, leveling agent, hair dyeing and bleaching agent or hot oil treatments. Depending on the field of application, the hair cosmetic preparations can be applied as (aerosol) spray, (aerosol) foam, gel, gel spray, cream, lotion or wax. Hairsprays include both aerosol sprays and pump sprays without propellant gas. Hair foams include both aerosol foams and pump foams without propellant gas. Hair sprays and hair foams preferably comprise predominantly or exclusively water-soluble or water-dispersible components. If the compounds used in the hair sprays and hair foams according to the invention are water-dispersible, they can be used in the form of aqueous microdispersions having particle diameters of usually from 1 to 350 nm, preferably from 1 to 250 nm. The solids contents of these preparations are usually in a range of about 0.5 to 20 wt .-%. As a rule, these microdispersions do not require emulsifiers or surfactants for their stabilization.

Other ingredients are understood to include the additives customary in cosmetics, for example propellants, defoamers, surface-active compounds, i. Surfactants, emulsifiers, foaming agents and solubilizers. The surface-active compounds used can be anionic, cationic, amphoteric or neutral. Other common ingredients may also be z. As preservatives, perfume oils, opacifiers, active ingredients, UV filters, care substances such as panthenol, collagen, vitamins, protein hydrolysates, alpha and beta

Hydroxycarboxylic acids, stabilizers, pH regulators, dyes, viscosity regulators, gelling agents, salts, humectants, refatting agents, complexing agents and other conventional additives.

Furthermore, this includes all known in cosmetics styling and conditioner polymers that can be used in combination with the microcapsules of the invention or the O / W dispersions prepared according to the inventive method, if very special properties are to be set.

Suitable conventional hair cosmetic polymers are, for example, the abovementioned cationic, anionic, neutral, nonionic and amphoteric polymers, to which reference is made here.

To adjust certain properties, the preparations may additionally contain conditioning substances based on silicone compounds. Suitable silicone compounds are, for example, polyalkylsiloxanes, polyarylsiloxanes, polyarylalkylsiloxanes, polyethersiloxanes, silicone resins or dimethicone copolyols (CTFA) and amino-functional silicone compounds such as amodimethicones (CTFA). Blowing agents are the blowing agents commonly used for hairsprays or aerosol foams. Preference is given to mixtures of propane / butane, pentane, dimethyl ether, 1,1-difluoroethane (HFC-152a), carbon dioxide, nitrogen or compressed air.

As emulsifiers, all emulsifiers commonly used in hair foams can be used. Suitable emulsifiers may be nonionic, cationic or anionic or amphoteric. Examples of nonionic emulsifiers (INCI nomenclature) are Laurethe, z. Laureth-4; Cetethe, z. Cetheth-1, polyethylene glycol cetyl ether, ceteareth, e.g. Cetheareth-25, polyglycol fatty acid glycerides, hydroxylated lecithin, lactyl esters of fatty acids, alkyl polyglycosides.

Examples of cationic emulsifiers are cetyldimethyl-2-hydroxyethylammonium dihydrogen phosphate, cetyltriamonium chloride, cetyltriammonium bromide, cocotriomonium methylsulfate, quaternium-1 to x (INCI).

Anionic emulsifiers may, for example, be selected from the group of alkyl sulfates, alkyl ether sulfates, alkyl sulfonates, alkylaryl sulfonates, alkyl succinates, alkyl sulfosuccinates, N-alkoyl sarcosinates, acyl taurates, acyl isethionates, alkyl phosphates, alkyl ether phosphates, alkyl ether carboxylates, alpha-olefin sulfonates, in particular the alkali metal and alkaline earth metal salts , z. As sodium, potassium, magnesium, calcium, and ammonium and triethanolamine salts. The alkyl ether sulfates, alkyl ether phosphates and alkyl ether carboxylates can have from 1 to 10 ethylene oxide or propylene oxide units, preferably 1 to 3 ethylene oxide units in the molecule.

As gel formers, all gel formers customary in cosmetics can be used. These include slightly crosslinked polyacrylic acid, for example carbomer (INCI), cellulose derivatives, eg. Hydroxypropyl cellulose, hydroxyethyl cellulose, cationic modified celluloses, polysaccharides, e.g. Xanthan gum, caprylic / capric triglyceride, sodium acrylate copolymers, polyquaternium-32 (and) paraffinum liquidum (INCI), sodium acrylate copolymers (and) paraffinum liquidum (and) PPG-1 trideceth-6, acrylamidopropyltrimonium chloride / acrylamide Copolymers, Steareth-10 Allyl Ethers, Acrylate Copolymers, Polyquaternium-37 (and) Paraffinum Liquidum (and) PPG-1 Trideceth-6, Polyquaternium 37 (and) Propylene Glycol Dicaprate Dicaprylate (and) PPG-1 Trideceth-6, Polyquaternium-7, Polyquaternium-44th

In the shampoo formulations all anionic, neutral, amphoteric or cationic surfactants commonly used in shampoos can be used.

Suitable anionic surfactants are, for example, alkyl sulfates, alkyl ether sulfates, alkyl sulfonates, alkylaryl sulfonates, alkyl succinates, alkyl sulfosuccinates, N-alkoylsarcosinates, acyl taurates, acyl isothionates, alkyl phosphates, alkyl ether phosphates, alkyl ether carboxylates, alpha-olefin sulfonates, especially the alkali and alkaline earth metal salts, e.g. For example, sodium, potassium, Magnesium, calcium, as well as ammonium and triethanolamine salts. The alkyl ether sulfates, alkyl ether phosphates and alkyl ether carboxylates can have from 1 to 10 ethylene oxide or propylene oxide units, preferably from 1 to 3 ethylene oxide units in the molecule.

For example, sodium lauryl sulfate, ammonium lauryl sulfate, sodium lauryl ether sulfate, ammonium lauryl ether sulfate, sodium lauroyl sarcosinate, sodium oleyl succinate, ammonium lauryl sulfosuccinate, sodium dodecyl benzene sulfonate, triethanolamine dodecyl benzene sulfonate are suitable.

Suitable amphoteric surfactants are, for example, alkylbetaines, alkylamidopropylbetaines, alkylsulfobetaines, alkylglycinates, alkylcarboxyglycinates, alkylamphoacetates or -propionates, alkylamphodiacetates or -dipropionates.

For example, cocodimethylsulfopropyl betaine, lauryl betaine, cocamidopropyl betaine or sodium cocamphopropionate can be used.

Suitable nonionic surfactants are, for example, the reaction products of aliphatic alcohols or alkylphenols having 6 to 20 C atoms in the alkyl chain, which may be linear or branched, with ethylene oxide and / or propylene oxide. The amount of alkylene oxide is about 6 to 60 moles per mole of alcohol. Also suitable are alkylamine oxides, mono- or dialkylalkanolamides, fatty acid esters of polyethylene glycols, alkyl polyglycosides or sorbitan ether esters.

In addition, the shampoo formulations may contain conventional cationic surfactants, such as. B. quaternary ammonium compounds, for example cetyltrimethylammonium chloride.

These include, for example, the abovementioned cationic polymers with the designation Polyquaternium according to INCI, in particular copolymers of vinylpyrrolidone / N-vinylimidazolium salts (Luviquat FC, Luviquat®, HM, Luviquat MS, Luviquat Care), copolymers of N-vinylpyrrolidone / dimethylaminoethyl methacrylate, quaternized with diethylsulfate. fat (Luviquat D PQ 1 1), copolymers of N-vinylcaprolactam / N-vinylpyrrolidone / N-vinylimidazolium salts (Luviquat D Hold), cationic cellulose derivatives (Polyquaternium-4 and -10), acrylamide copolymers (Polyquaternium-7). Furthermore, protein hydrolysates can be used, as well as conditioning substances based on silicone compounds, for example polyalkylsiloxanes, polyarylsiloxanes, polyarylalkylsiloxanes, polyethersiloxanes or silicone resins. Further suitable silicone compounds are dimethicone copolyols (CTFA) and amino-functional silicone compounds such as amodimethicones (CTFA). Furthermore, cationic guar derivatives such as guar hydroxypropyltrimonium chloride (INCI) can be used.

According to a further embodiment, this hair-cosmetic or skin-cosmetic preparation is for the care or protection of the skin or hair and is in the form of an emulsion, a dispersion, a suspension, an aqueous surfactant preparation, a milk, a lotion, a cream, a balm, an ointment, a gel, a granule, a powder, a stick preparation, such. As a lipstick, a foam, an aerosol or a Sprays in front. Such formulations are well suited for topical preparations. Suitable emulsions are oil-in-water emulsions and water-in-oil emulsions or microemulsions.

As a rule, the dermocosmetic is used to protect the hair for application to the skin (topically) or to the hair. Topical dermocosmetics are to be understood as those dermocosemtics which are suitable for applying the active ingredients to the skin in fine distribution and preferably in a form absorbable by the skin. For this purpose, z. As aqueous and aqueous-alcoholic solutions, sprays, foams, foam aerosols, ointments, aqueous gels, emulsions of the O / W or W / O type, microemulsions or cosmetic stick preparations.

According to a preferred embodiment of the dermocosmetics according to the invention for the protection of the hair, the dermocosmetic contains a carrier. Preferred carrier is water, a gas, a water-based liquid, an oil, a gel, an emulsion or microemulsion, a dispersion or a mixture thereof. The mentioned carriers show good skin tolerance. Particularly advantageous for topical preparations are aqueous gels, emulsions or microemulsions.

Nonionic surfactants, zwitterionic surfactants, ampholytic surfactants or anionic emulsifiers can be used as emulsifiers. The emulsifiers may be present in the composition according to the invention in amounts of from 0.1 to 10, preferably from 1 to 5,% by weight, based on the composition.

As a nonionic surfactant, for example, a surfactant of at least one of the following groups may be used:

Addition products of from 2 to 30 mol of ethylene oxide and / or from 0 to 5 mol of propylene oxide to linear fatty alcohols having C8-C22 C atoms, to fatty acids having C12-C22 C atoms and to alkylphenols having Cs-ds C atoms in the alkyl group;

Ci2Ci8 fatty acid mono- and diesters of addition products of 1 to 30 moles of ethylene oxide with glycerol; Glycerol mono- and diesters and sorbitan mono- and diesters of saturated and unsaturated fatty acids having C6-C22 carbon atoms and their ethylene oxide addition products; Alkyl mono- and oligoglycosides with C8-C22 carbon atoms in the alkyl radical and their ethoxylated analogs; Addition products of 15 to 60 moles of ethylene oxide with castor oil and / or hydrogenated castor oil; Polyol and in particular polyglycerol esters, such as. Polyglycerol polyricinoleate, polyglycerol poly-12-hydroxy stearate or polyglycerol dimerate. Also suitable are mixtures of compounds of several of these classes of substances; Addition products of 2 to 15 moles of ethylene oxide with castor oil and / or hydrogenated castor oil; Partial esters based on linear, branched, unsaturated or saturated C6 / 22-fatty acids, ricinoleic acid and 12-hydroxystearic acid and glycerol, polyglycerol, pentaerythritol, dipenta erythritol, sugar alcohols (eg sorbitol), alkyl glucosides (eg methyl glucoside, butyl glucoside, lauryl glucoside) and polyglucosides (eg cellulose); Mono-, di- and trialkyl phosphates and mono-, di- and / or tri-PEG-alkyl phosphates and their salts;

Furthermore, zwitterionic surfactants can be used as emulsifiers. Zwitterionic surfactants are those surface-active compounds which carry at least one quaternary ammonium group and at least one carboxylate or one sulfonate group in the molecule. Particularly suitable zwitterionic surfactants are the so-called betaines, such as N-alkyl-N, N-dimethylammonium glycinates, for example cocoalkyldimethylammonium glycinate, N-acylamino-propyl-N, N-dimethylammonium glycinates, for example cocoacylaminopropyldimethylammonium glycinate, and 2-alkyl-3-ol Carboxylmethyl-3-hydroxyethyl imidazolines having in each case 8 to 18 carbon atoms in the alkyl or acyl group, and the coco cylaminoethylhydroxyethyl carboxymethylglycinat. Particularly preferred is the known under the CTFA name Cocamidopropyl Betaine fatty acid amide derivative.

Also suitable emulsifiers are ampholytic surfactants. Ampholytic surfactants are to be understood as meaning those surface-active compounds which, in addition to a Cs-ds-alkyl or acyl group in the molecule, contain at least one free amino group and at least one -COOH or -CHhH group and are capable of forming internal salts. Examples of suitable ampholytic surfactants are N-alkylglycines, N-alkylpropionic acids, N-alkylamino-butanoic acids, N-alkyliminodipropionic acids, N-hydroxyethyl-N-alkylamido-propylglycines, N-alkyltaurines, N-alkylsarcosines, 2-alkylaminopropionic acids and alkylaminoacetic acids each having about 8 to 18 C atoms in the alkyl group.

Particularly preferred ampholytic surfactants are N-cocoalkylaminopropionate, cocoacylaminoethylaminopropionate and C 12 -C 18 -acylsarcosine. In addition to the ampholytic, quaternary emulsifiers are also suitable, those of the esterquat type, preferably methyl-quaternized difatty acid triethanolamine ester salts, being particularly preferred. In addition, alkyl ether sulfates, monoglyceride sulfates, fatty acid sulfates, sulfosuccinates and / or ether carboxylic acids can be used as anionic emulsifiers.

Guerbet alcohols based on fatty alcohols having 6 to 18, preferably 8 to 10, carbon atoms, esters of linear C6-C22 fatty acids with linear C6-C22 fatty alcohols, esters of branched C6-C13 carboxylic acids with linear C6-C22 fatty alcohols , Esters of linear C6-C22 fatty acids with branched alcohols, in particular 2-ethylhexanol, esters of linear and / or branched fatty acids with polyhydric alcohols (such as propylene glycol, dimerdiol or trimer triol) and / or Guerbet alcohols, triglycerides Base Ce- Cio fatty acids, liquid mono- / di-, triglyceride mixtures based on Cβ-C-is fatty acids, esters of C6-C22 fatty alcohols and / or Guerbet alcohols with aromatic carboxylic acids, especially benzoic acid, esters of C2-Ci2- Dicarboxylic acids with linear or branched alcohols having 1 to 22 carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 hydroxyl groups, vegetable oils, branched primary alcohols, subst hydrogenated cyclohexanes, linear C6-C22-fatty alcohol carbonates, Guerbet carbonates, esters of benzoic acid with linear and / or branched C6-C22-alcohols (eg. B. Finsolv ^® TN), dialkyl ethers, ring opening products of epoxidized Fettsäureestern with polyols, silicone oils and / or aliphatic or naphtheni - Hydrocarbons into consideration. As oil body, silicone compounds can furthermore also be used, for example dimethylpolysiloxanes, methylphenylpolysiloxanes, cyclic silicones and amino, fatty acid, alcohol, polyether, epoxy, fluorine, alkyl and / or glycoside-modified silicone compounds which are both liquid at room temperature may be present as well as resinous. The oil bodies may be present in the compositions according to the invention in amounts of from 1 to 90, preferably from 5 to 80, and in particular from 10 to 50,% by weight, based on the composition.

perfumes

Another embodiment of the dermocosmetics are perfumes which contain or have been prepared using at least one of the compounds (V), mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations.

Perfumes are alcoholic solutions of suitable fragrances or fragrances, which usually consist of perfume oils of plant or synthetic origin but may also contain substances which have been obtained from animals and are, for example, animal glandular secretions. Perfumes are used in addition to human application and often fragrance design of many solids and liquids. Perfumes may be classified into groups based on the content of the perfume oils in particularly pure ethanol, which may optionally be diluted with water up to 70% by weight. It is usually divided into: perfume with from 10 to 25 wt.% Perfume oil; Eau de Parfum with from 8 to 10% by weight of perfume oil; Eau de Toilette with from 5 to 8% by weight of perfume oil; Eau de Cologne (colognes) with from 2 to 5% by weight of perfume oil. The percentages by weight are based on the total weight of the perfume.

The fragrance effect of a perfume is usually composed of three elements; a top note that contains volatile fragrances or perfume oils with mostly fresh character, a middle note that contains moderately volatile fragrances or perfume oils often flowery character and a base note with low-volatile fragrances or perfume oils and determine the basic character (Leitgeruch) of the perfume ,

Perfumes can be subdivided into fragrance groups or fragrances or notes: aldehyde-like datura notes contain Ce- to Cv-aldehydes, which smell fresh and fruity. Grunnoten consist predominantly of tartaric synthetic aldehydes alcohols and esters. Flowery notes are complex mixtures of, for example, Jasrnin absolues, rose oil, synthetic fragrances such as benzyl acetate, phenylethyi alcohol. Herbaceous notes contain, for example, lavender, moss extracts and spices. Cinnamon and are commonly used in men's perfumes. Oriental notes are heavy and sweet and often enhanced with animal notes. The base notes are generally associated with fixatives, which increase the binding and adhesive strength of the volatile fragrances and stabilize the fragrance composition. With adjuvants, the top note, middle note and base note can be more closely linked and the scent flow can be made more fluid. Fixators can be differentiated, for example, into self-fixatives, pseudofixators, true fixatives or stimulants, and consist of natural products, synthetic analogs or synthetic substances. They are in liquid or viscous to crystalline form. Examples of substances or extracts which can act as fixatives are: coumarin, diethylene glycol methyl ether, amber, castoreum, musk, civet, muscone, some macrolides, fixator 404 or extracts of labdanum, styrax, tolu balsam, benzoin, iris, egg moss, opopanax ,

In the perfumes, in addition to the perfume oils or fragrances or fragrances, further substances such as emulsifiers or stabilizers, antioxidants or preservatives are present.

The perfumes according to the invention generally contain from 0.01 to 30% by weight, preferably from 0.01 to 15% by weight, particularly preferably from 0.05 to 5% by weight, very particularly preferably from 0.1 to 2% by weight .% of the antioxidants of the invention, the mixtures (M1) or (M2), the preparation, the colorant, the vesicles or the carotenoid formulations, based on the total weight of the perfume.

Perfumes are usually topically applied to the human skin, but they can also serve, for example, to improve the indoor air or be used in other dermocosmetics, such as soaps or ointments, pharmaceuticals, solids or liquids or their mixtures or combined with them.

Mouth, tooth, and dentures

Further uses of the antioxidants of the invention, mixtures (M1) or

(M2), preparations, colorants, vesicles or carotenoid formulations are mouthwash, dentifrice and dentifrice compositions containing them or made using them.

Means for oral, dental and dental care in the context of the present invention means all the oral, dental and dental hygiene appropriate means and supply forms as in textbooks, z. B. Limbach: Cosmetics: Development, production and use of cosmetic products, Chapter 7, page 187-219, 2nd extended edition, 1995, Georg Thieme Verlag, ISBN 3 13 712602 9, which is incorporated herein by reference. These means and forms of offer are familiar to the expert and include z. As toothpowder, toothpastes, toothpastes, children's toothpastes, dental gels, liquid toothpastes, mouthwash and mouthwashes, this list is not exhaustive. The preparation of such agents is familiar to the expert and can general textbooks (eg Limbach: cosmetics: development, production and use of cosmetic products, 2nd extended edition, 1995, Georg Thieme Verlag, ISBN 3 13 7126029) are removed. Thus, in addition to the antioxidants, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations according to the invention, these agents may also contain further ingredients known to the person skilled in the art. It may be z. For example, surfactants, cleaners, binders, humectants, bodying agents, preservatives, dyes, flavors and sweeteners act, this list is not exhaustive. The active substances and auxiliaries mentioned may be active substances and adjuvants which prevent tooth decay and gingivitis. In particular, the fluoride is to be mentioned. Furthermore, these active ingredients and adjuvants z. B. against plaque bacteria and calculus, promote remineralization, desensitize sensitive dental necks or protect the gums. On the textbook Limbach: Cosmetics: Development, manufacture and application of cosmetic products, 2nd extended edition, 1995, Georg Thieme Verlag, ISBN 3 13 712602 9, on pages 205 to 207 shown recipe examples are hereby incorporated by reference.

The compositions according to the invention for oral, dental and dental care generally contain from 0.01 to 30% by weight, preferably from 0.01% by weight to 15% by weight, particularly preferably from 0.05 to 5% by weight. , very particularly preferably from 0.1 to 2% by weight of the antioxidants according to the invention, of the mixtures (M1) or (M2), of the preparations, of the colorants, of the vesicles or of the carotenoid formulations, based on the total weight of the mouthwash composition. , Dental and dental care.

The use of the agents for oral, dental and dental care are known to those skilled in the art and users of these agents in general. The funds are either introduced into the oral cavity in sufficient quantity or, for example, in a suitable vessel with the object to be cleaned or cared for, for example, the dentures, brought into contact and removed after a dependent of the respective agent exposure time. To use the means for oral, dental and Zahnersatzplege may possibly further aids such as toothbrushes may be needed.

Pharmaceuticals Another object of the present invention is the use of the antioxidants according to the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations in or for the production of pharmaceuticals. The antioxidants, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations can be used for their antioxidant protection, for coloring, as a formulation adjuvant or as an active substance. The antioxidant protective action may, for example, relate to the pharmaceutical active substance or other constituents of the pharmaceutical, for example formulation auxiliaries, and lead to a stabilization of the pharmaceutical in question. For the preparation of the pharmaceuticals or in the pharmaceuticals, the compounds (V) are preferably in enriched form, particularly preferably in pure form and very particularly preferably in crystalline or micronized form or in the form of H or J aggregates, or in mixtures of this before. Pharmaceuticals are all agents which contain at least one pharmaceutical active substance in a pharmaceutically active concentration and are used for the prophylaxis or therapy of diseases in humans or animals. They may, for example, be in the form of aerosols, juices, drops, ointments, gels, tablets, dragees or suppositories, or be present in other auxiliaries, for example in patches.

Furthermore, the antioxidants according to the invention can be used as active substance in pharmaceuticals. This plays a role in particular in physiological or pathological processes, which are influenced by oxidation. Examples of such processes are macular degeneration, inflammatory inflammation, cardiovascular diseases, atherosclerosis, strokes, heart infections, Alzheimer's and other neurodegenerative processes or hypertension. The compounds (V) or the antioxidants according to the invention can be used in pharmaceuticals analogous to the carotenoid-ether analogues in US 2005/0065096 A1. Here are also examples of possible fields of application, forms of application or advantageously usable cleavable protecting groups.

The compounds (V) are preferably present in pharmaceuticals in a physiologically acceptable form and / or in a more readily soluble form in an aqueous medium. For example, they are derivatized as a physiologically acceptable salt and / or with a readily cleavable protecting group.

As a rule, the pharmaceuticals according to the invention contain from 0.01 to 30% by weight, preferably from 0.01 to 15% by weight, more preferably from 0.05 to 5% by weight, very particularly preferably from 0.1 to 2% by weight of the antioxidants according to the invention, of the mixtures (M1) or (M2), of the preparation, of the colorants, of the vesicles or of the carotenoid formulations, based on the total weight of the pharmaceutical.

The application of the corresponding pharmaceuticals depends, for example, on the type, concentration and physiological availability of the active substance or active substances contained in the pharmaceuticals. Furthermore, it depends on the type of disease to be treated or treated prophylactically.

The application forms, application sites and required drug concentrations are known in the art.

Food and feed

Another object of the invention are food or feed containing at least one of the compounds (V) or the antioxidants of the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations or were prepared using them. The compounds (V) are used in the food and feed preferably in enriched form, more preferably in pure form and most preferably in crystalline or micronized form.

Foodstuffs are understood here to mean all substances and substance mixtures which are suitable for human consumption. This applies to products such as baked goods, dairy products, products of animal origin, for example meat and sausage products, vegetable and fruit preparations, desserts and sweets, snack foods such as potato chips or pretzel sticks, but also chewing gum, jellies or drinks such as sodas or alkoholica. These foods may be ready-to-eat, such as yoghurt, charcuterie or beverages, as raw products for processing in commercial kitchens or in the home, as finished products such as frozen or ready-made soups, or as blends for further processing, such as home-baking mixes or bakeries or for example as custard powder become. Furthermore, the term includes foods that are supposed to exert a special effect on the body. Examples would be nutraceuticals, functional foods, isotonic drinks and nutritional supplements in the form of juices, tablets, effervescent tablets, dragees, gels, jellies, gelatine capsules, such as hard or soft gelatin chips, powders or dispersions, suspensions or solids. Excluded from the foodstuffs are foods which contain a compound (Ia) or compound (II) or mixtures thereof produced by a naturally occurring organism. Such may be red smear cheese, eggs, poultry or poultry skin.

Foodstuffs within the meaning of the invention are also foods which are used preventively or therapeutically. Preventive foods are understood to be foods enriched in certain health-promoting ingredients of so-called nutraceuticals or from which harmful ingredients have been removed or reduced. For the purposes of this invention, therapeutic foods are understood as meaning foods which are suitable both for reducing body weight but also for building muscle. B. in popular and competitive sports, especially in body building. The use according to the invention of antioxidants or preparations containing them according to the invention is explicitly included in dietetic foods.

Furthermore, therapeutic agents can bring about an improvement in lean body mass in humans. In one embodiment, therapeutic agents are understood to mean those agents which are used both for the prevention and for the therapeutic treatment of dietary, genetically induced or metabolic disorders induced obesity. In the therapeutic treatment of obesity, the compositions of the present invention may be formulated in a manner well known and practiced by one skilled in the art and used to prepare pharmaceutical dosage forms using conventional techniques. Such techniques are described, for example, in "Remington ^'s Pharmaceutical Science Handbook, Mack Publishing Co., New York, USA, 17th Edition 1985. Such pharmaceutical dosage forms or food additives may be liquids or solids in the form of, for example, powders, premixes, tablets, capsules, dragees, aerosols, solutions, dispersions or suspensions. be used. This applies both to feeds used for animal feed, for normal nutrition or for the promotion of health or the appearance, for example for coloring the plumage. Excluded are feeds containing naturally occurring compounds (Ia) or (II) or mixtures thereof. Also excluded are feeds containing naturally occurring organisms which produce at least one of the compounds (Ia) or (II). For the purposes of the present invention, an animal organism is understood to mean the organisms which are taxonomically assigned to the animal kingdom (Animalia).

The vertebrates (Vertebrata) with the rows of terrestrial vertebrates (Tetrapoda) and fish (Pisces) are preferred. Particularly preferred are the classes Aves (birds) and mammalia (mammals). Invertebrates, in particular crustaceans such as shrimp and crayfish or echinoderms such as sea cucumbers (Holothuroidea), are by no means excluded. Especially preferred are the families of the swine (Suidae), cattle (Bovinae), horses (Equidae), pheasant (Phasianidae), duck birds (Anatidae), parrot birds (Psittaciformes), finches (Fringillidae), carp fish (Cyprinidae) and Trout fish (salmonidae). Of these families, the most preferred are the so-called domestic and farm animals. Within the meaning of the present invention, domestic animals are understood to mean animals that are not living freely and that are used to humans and that are predominantly kept in the dwelling by humans. Particularly preferred pets are cats (Felis silvestris forma catus) and dogs (Canis lupus familiaris). Within the meaning of the present invention, livestock animals are understood to be animals that are kept by the human being for economic purposes.

Particularly preferred farm animals are the species domestic cattle (Bos taurus), domestic chicken (Gallus gallus domesticus), domestic pig (Sus scrofa domestica), domestic sheep (Ovis ammon aries) and domesticated forms of gray goose (Anser anser).

The compounds (V) or the antioxidants of the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations may protect food and feed against oxidative processes affecting the quality and / or shelf life of these products be used negatively. However, the compounds (V) can also be used to protect the animal organism against oxidative stress and thereby maintain or improve its health. The compounds (V) may be added to the food or feed in liquid form, for example as a dispersion or in solid form, for example in a dried or frozen state.

The foodstuffs or feedstuffs according to the invention generally contain from 0.01 to 30% by weight, preferably from 0.01% by weight to 15% by weight, particularly preferably from 0.05 to 5% by weight, very particularly preferably from 0.1 to 2 wt.% Of the antioxidant of the invention, the mixture (M1) or (M2), the preparation, the colorant, the vesicle or the carotenoid formulation, based on the total weight of the food or feed.

The application or use of the food or feed is known to the skilled person.

The list of the specified ingredients which can be used together with the antioxidants according to the invention or prepared according to the invention, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations, or for the production of dermocosmetics, pharmaceuticals Food, feed, solids or liquids or mixtures thereof should of course not be considered as limiting or limiting. The ingredients may be used alone or in any combination with each other.

In the following, dermocosmetics according to the invention are described, containing one or more of the compounds (V). These are abbreviated in the examples as VERB. (V). It is obvious to the person skilled in the art that all named VERB. (V) addressed compounds (V) can be used preferably individually but also in any combination in the below-mentioned preparations. The respectively preferred compound (V) is 3,3'-dihydroxyisorenieratin.

Example 1: Use of VERB. (V) in an emulsion for day care - Type O / W

WS 1%:

% Ingredient (INCI)

A 1, 7 Ceteareth-6, Stearyl Alcohol

0.7 Ceteareth-25

2.0 diethylamino hydroxybenzoyl hexyl benzoate

2.0 PEG-14 Dimethicone

3.6 Cetearyl Alcohol

6.0 ethylhexyl methoxycinnamate

2.0 dibutyl adipate

B 5.0 glycerin

0.2% disodium EDTA

1, 0 panthenol q.s. preservative

67.8 Aqua the.

C 4.0 Caprylic / Capric Triglyceride, Sodium Acrylate Copolymer

D 0.2 Sodium Ascorbyl Phosphate

1, 0 tocopheryl acetate

0.2 bisabolol 1, 0 Caprylic / Capric Triglycerides, Sodium Ascorbate, Tocopherol, Retinol 1, 0 oily solution with about 5% VERB. (V)

Eq. S. Sodium hydroxides

WS 5%:

% Ingredient (INCI)

A 1, 7 Ceteareth-6, Stearyl Alcohol

0.7 Ceteareth-25

2.0 diethylamino hydroxybenzoyl hexyl benzoate

2.0 PEG-14 Dimethicone

3.6 Cetearyl Alcohol

6.0 ethylhexyl methoxycinnamate

2.0 dibutyl adipate

B 5.0 glycerin

0.2% disodium EDTA

1, 0 panthenol q.s. preservative

63.8 Aqua the.

C 4.0 Caprylic / Capric Triglyceride, Sodium Acrylate Copolymer

D 0.2 Sodium Ascorbyl Phosphate

1, 0 tocopheryl acetate

0.2 bisabolol

1, 0 Caprylic / Capric Triglyceride, Sodium Ascorbate, Tocopherol, Retinol

5.0 oily solution with about 5% VERB. (V)

E q.s. Sodium hydroxides

Preparation: Heat phases A and B separately from each other to about 80 ^° C. Stir phase B into phase A and homogenize. Introduce phase C into combined phases A and B and homogenize again. Cool to about 40 ^° C. with stirring, add phase D, adjust the pH to about 6.5 with phase E, homogenize and cool to room temperature while stirring.

Note: The formulation is produced without inert gas. The filling must be in oxygen-impermeable packaging, eg. B. aluminum tubes.

Example 2: Use of VERB. (V) in a protective day cream - Type O / W WS 1%:

% Ingredient (INCI) A 1, 7 Ceteareth-6, Stearyl Alcohol 0.7 Ceteareth-25 2.0 Diethylamino Hydroxybenzoyl Hexyl Benzoate 2.0 PEG-14 Dimethicone

3.6 Cetearyl Alcohol

6.0 ethylhexyl methoxycinnamate

2.0 dibutyl adipate

B 5.0 glycerin

0.2% disodium EDTA

1, 0 panthenol q.s. preservative

68.6 Aqua the.

C 4.0 Caprylic / Capric Triglyceride, Sodium Acrylate Copolymer

D 1, 0 Sodium ascorbyl phosphates

1, 0 tocopheryl acetate

0.2 bisabolol

1, 0 oily solution with about 5% VERB. (V)

E q.s. Sodium hydroxides

5%:

% Ingredient (INCI)

A 1, 7 Ceteareth-6, Stearyl Alcohol

0.7 Ceteareth-25

2.0 diethylamino hydroxybenzoyl hexyl benzoate

2.0 PEG-14 Dimethicone

3.6 Cetearyl Alcohol

6.0 ethylhexyl methoxycinnamate

2.0 dibutyl adipate

B 5.0 glycerin

0.2% disodium EDTA

1, 0 panthenol q.s. preservative

64.6 Aqua the.

C 4.0 Caprylic / Capric Triglyceride, Sodium Acrylate Copolymer

D 1, 0 Sodium ascorbyl phosphates

1, 0 tocopheryl acetate

0.2 bisabolol

5.0 oily solution with about 5% VERB. (V)

E q.s. Sodium hydroxides

Preparation: Heat phases A and B separately from each other to about 80 ^° C. Stir phase B into phase A and homogenize. Prepare phase C in combined phases A and B and homogenize. Cool to about 40 ^° C. while stirring. Add phase D, adjust the pH to about 6.5 with phase E and homogenize. Cool to room temperature while stirring. Example 3: Use of VERB. (V) in a facial cleansing lotion - Type O / W WS 1%:

% Ingredient (INCI)

A 10.0 Cetearyl ethylhexanoate

10.0 Caprylic / Capric Triglycerides

1, 5 cyclopentasiloxanes, cyclohexasilosans

2.0 PEG-40 Hydrogenated Castor OiI

B3.5 Caprylic / Capric Triglycerides, Sodium Acrylates Copolymer

C 1, 0 tocopheryl acetate

0.2 bisabolol q.s. Preservatives q.s. perfume oil

D 3.0 polyquaternium-44

0.5 cocotrimonium methosulfates

0.5 ceteareth-25

2.0 Panthenol, Propylene Glycol

4.0 Propylene Glycol

0.1% disodium EDTA

1, 0 oily solution with about 5% VERB. (V)

60.7 Aqua.

WS 5%:

% Ingredient (INCI)

A 10.0 Cetearyl ethylhexanoate

10.0 Caprylic / Capric Triglycerides

1, 5 cyclopentasiloxanes, cyclohexasilosans

2.0 PEG-40 Hydrogenated Castor OiI

B3.5 Caprylic / Capric Triglycerides, Sodium Acrylates Copolymer

C 1, 0 tocopheryl acetate

0.2 bisabolol q.s. Preservatives q.s. perfume oil

D 3.0 polyquaternium-44

0.5 cocotrimonium methosulfates

0.5 ceteareth-25

2.0 Panthenol, Propylene Glycol

4.0 Propylene Glycol

0.1% disodium EDTA

5.0 oily solution with about 5% VERB. (V)

56.7 Aqua the.

Preparation: Release phase A. Stir phase B into phase A, incorporate phase C into combined phases A and B. Dissolve phase D, stir into the combined phases A, B and C and homogenize. Stir for 15 minutes.

Example 4: Use of VERB. (V) in a Daily Care Body Spray

WS 1%:

% Ingredient (INCI)

3.0 ethylhexyl methoxycinnamate

2.0 diethylamino hydroxybenzoyl hexyl benzoate

1, 0 Polyquaternium-44

3.0 Propylene Glycol

2.0 Panthenol, Propylene Glycol

1, 0 cyclopentasiloxanes, cyclohexasiloxanes

10.0 octyldodecanol

0.5 PVP

10.0 Caprylic / Capric Triglycerides

3.0 C12-15 alkyl benzoates

3.0 glycerin

1, 0 tocopheryl acetate

0.3 bisabolol

1, 0 oily solution with about 5% VERB. (V) 59.2 Alcohol

I 5%:

% Ingredient (INCI)

3.0 ethylhexyl methoxycinnamate

2.0 diethylamino hydroxybenzoyl hexyl benzoate

1, 0 Polyquaternium-44

3.0 Propylene Glycol

2.0 Panthenol, Propylene Glycol

1, 0 cyclopentasiloxanes, cyclohexasiloxanes

10.0 octyldodecanol

0.5 PVP

10.0 Caprylic / Capric Triglycerides

3.0 C12-15 alkyl benzoates

3.0 glycerin

1, 0 tocopheryl acetate

0.3 bisabolol

5.0 oily solution with about 5% VERB. (V)

55.2 Alcohol

Preparation: Weigh in the components of phase A and dissolve clearly.

Example 5: Use of VERB. (V) in a skin care gel WS 1%:

% Ingredient (INCI)

3.6 PEG-40 Hydrogenated Castor OiI

15.0 Alcohol

0.1 bisabolol

0.5 tocopheryl acetate q.s. perfume oil

B 3.0 Panthenol

0.6 carbomer

1, 0 oily solution with about 5% VERB. (V)

75.4 Aqua,

0.8 triethanolamine WS 5%:

% Ingredient (INCI)

3.6 PEG-40 Hydrogenated Castor OiI

15.0 Alcohol

0.1 bisabolol

0.5 tocopheryl acetate q.s. perfume oil

B 3.0 Panthenol

0.6 carbomer

5.0 oily solution with about 5% VERB. (V)

71, 4 Aqua,

0.8 triethanolamine

Preparation: Clear phase A clearly. Swell phase B and neutralize with phase C. Stir phase A into the homogenized phase B and homogenize.

Example 6: Use of VERB. (V) in an aftershave lotion

WS 1%:

% Ingredient (INCI)

10.0 Cetearyl ethylhexanoates

5.0 tocopheryl acetates

1, 0 Bisabolol

0.1 perfume oil

0.3 Acrylates / C 10-30 Alkyl Acrylate Crosspolymer

B 15.0 Alcohol

1, 0 panthenol

3.0 glycerin

1, 0 oily solution with about 5% VERB. (V)

0.1 triethanolamine

63.5 Aqua the.

WS 5%:

% Ingredient (INCI)

10.0 Cetearyl ethylhexanoates

5.0 tocopheryl acetates

1, 0 Bisabolol

0.1 perfume oil

0.3 Acrylates / C 10-30 Alkyl Acrylate Crosspolymer

B 15.0 Alcohol

1, 0 panthenol

3.0 glycerin

5.0 oily solution with about 5% VERB. (V)

0.1 triethanolamine

59.5 Aqua the.

Preparation: Mix the components of phase A. Dissolve phase B, work in phase A and homogenize.

Example 7: Use of the VERB. (V) in an After Sun Lotion WS 1%:

% Ingredient (INCI)

0.4 Acrylates / C 10-30 Alkyl Acrylate Crosspolymer

15.0 Cetearyl ethylhexanoates

0.2 bisabolol

1, 0 tocopheryl acetate q.s. perfume oil

B 1, 0 panthenol

15.0 Alcohol

3.0 glycerin

1, 0 oily solution with about 5% VERB. (V)

63.2 Aqua,

0.2 triethanolamine

WS 5%:

% Ingredient (INCI)

0.4 Acrylates / C 10-30 Alkyl Acrylate Crosspolymer

15.0 Cetearyl ethylhexanoates

0.2 bisabolol

1, 0 tocopheryl acetate q.s. perfume oil

B 1, 0 panthenol

15.0 Alcohol

3.0 glycerin

5.0 oily solution with about 5% VERB. (V)

59.2 Aqua,

0.2 triethanolamine

Preparation: Mix the components of phase A. Stir phase B into phase A while homogenizing. Neutralize with Phase C and homogenize again.

Example I 8: Use of VERB. (V) in a sunscreen lotion

WS 1%

% Ingredient (INCI)

A 4,5 ethylhexyl methoxycinnamate

2.0 diethylamino hydroxybenzoyl hexyl benzoate

3.0 octocrylene

2.5% Di-CI 2-13 alkyl malate

0.5 tocopheryl acetate

4.0 polyglyceryl-3 methyl glucose distearate

B 3,5 Cetearyl isononanoate

1, 0 VP / eicosene copolymer

5.0 isohexadecane

2.5% Di-CI 2-13 alkyl malate

3.0 Titanium dioxides, trimethoxycaprylylsilanes

C 5.0 glycerin

1, 0 Sodium Cetearyl Sulfate

0.5 xanthan gum

59.7 Aqua the.

D 1, 0 oily solution with about 5% VERB. (V)

1, 0 phenoxyethanol, methylparaben, ethylparaben, butylparaben, propylparaben, isobutylparaben

0.3 bisabolol WS 5%:

% Ingredient (INCI)

A 4,5 ethylhexyl methoxycinnamate

2.0 Diethylamino Hydroxybenzoyl Hexyl Benzoate 3.0 Octocrylene

2.5% Di-CI 2-13 alkyl malate

0.5 tocopheryl acetate

4.0 polyglyceryl-3 methyl glucose distearate

B 3.5 Cetearyl isononanoate 1, 0 VP / eicosene copolymer

5.0 isohexadecane

2.5% Di-CI 2-13 alkyl malate

3.0 Titanium dioxides, trimethoxycaprylylsilanes

C 5.0 Glycerin 1, 0 Sodium Cetearyl Sulfate

0.5 xanthan gum

55.7 Aqua.

D 5.0 oily solution with about 5% VERB. (V)

1, 0 phenoxyethanol, methylparaben, ethylparaben, butylparaben, propylparaben, isobutylparaben

0.3 bisabolol

Preparation: Heat the components of phases A and B separately to about 80 ^° C. Stir phase B into phase A and homogenize. Heat phase C to about 80 ^° C. and stir into the combined phases A and B while homogenizing. Cool with stirring to about 40 ° C, add phase D and homogenize again.

Example 9: Use of VERB. (V) in a sunscreen lotion - Type O / W WS 1%:

% Ingredient (INCI)

A 2.0 Ceteareth-6, Stearyl Alcohol 2.0 Ceteareth-25

3.0 tribehenin

2.0 Cetearyl Alcohol

2.0 cetearyl ethylhexanoate

5.0 ethylhexyl methoxycinnamate 1, 0 ethylhexyl triazone

1, 0 VP / eicosene copolymer

7.0 isopropyl myristate

B 5.0 Zinc oxides, triethoxycaprylylsilanes

C 0.2 xanthan gum 0.5 hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer,

Squalane, polysorbate 60

0.2% disodium EDTA

5.0 Propylene Glycol

0.5 Panthenol 60.9 Aqua dem.

D 1, 0 oily solution with about 5% VERB. (V)

0.5 phenoxyethanol, methylparaben, butylparaben, ethylparaben, propylparaben, isopropylparaben

1, 0 tocopheryl acetate 0.2 bisabolol

WS 5%:

% Ingredient (INCI)

A 2.0 Ceteareth-6, Stearyl Alcohol 2.0 Ceteareth-25

3.0 tribehenin

2.0 Cetearyl Alcohol

2.0 cetearyl ethylhexanoate

5.0 ethylhexyl methoxycinnamate 1, 0 ethylhexyl triazone

1, 0 VP / eicosene copolymer

7.0 isopropyl myristate

B 5.0 Zinc oxides, triethoxycaprylylsilanes

C 0.2 xanthan gum 0.5 hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer,

Squalane, polysorbate 60

0.2% disodium EDTA 5.0 Propylene Glycol

0.5 panthenol

56.9 Aqua the.

D 5.0 oily solution with about 5% VERB. (V) 0.5 phenoxyethanol, methylparaben, butylparaben, ethylparaben, propylparaben, isopropylparaben

1, 0 tocopheryl acetate

0.2 bisabolol

Preparation: Heat phase A to approx. 80 ^° C., stir in phase B and homogenize for 3 minutes. Also heat phase C to 80 ^° C. and stir into the combined phases A and B while homogenizing. Cool to about 40 ° C, stir in phase D and homogenize again.

Example 10: Use of VERB. (V) in a sunscreen lotion - Type O / W

WS 1%:

% Ingredient (INCI)

A 3,5 Ceteareth-6, Stearyl Alcohol

1, 5 Ceteareth-25

7.5 ethylhexyl methoxycinnamate

2.0 diethylamino hydroxybenzoyl hexyl benzoate

2.0 cyclopentasiloxanes, cyclohexasiloxanes

0.5 Bees Wax

3.0 Cetearyl Alcohol

10.0 Caprylic / Capric Triglycerides

B 5.0 Titanium Dioxide, Silica, Methicone, Alumina

C 3.0 glycerin

0.2% disodium EDTA

0.3 xanthan gum

1, 0 decyl glucosides

2.0 Panthenol, Propylene Glycol

56.3 Aqua the.

D 1, 0 oily solution with about 5% VERB. (V)

1, 0 tocopheryl acetate

0.2 bisabolol qs perfume oil qs preservative WS 5%:

% Ingredient (INCI)

A 3,5 Ceteareth-6, Stearyl Alcohol

1, 5 Ceteareth-25

7.5 ethylhexyl methoxycinnamate

2.0 diethylamino hydroxybenzoyl hexyl benzoate

2.0 cyclopentasiloxanes, cyclohexasiloxanes

0.5 Bees Wax

3.0 Cetearyl Alcohol

10.0 Caprylic / Capric Triglycerides

B 5.0 Titanium Dioxide, Silica, Methicone, Alumina

C 3.0 glycerin

0.2% disodium EDTA

0.3 xanthan gum

1, 0 decyl glucosides

2.0 Panthenol, Propylene Glycol

52.3 Aqua the.

D 5.0 oily solution with about 5% VERB. (V)

1, 0 tocopheryl acetate

0.2 bisabolol q.s. Perfume oil q.s. preservative

Preparation: Heat phase A to approx. 80 ^° C., stir in phase B and homogenize for 3 minutes. Also heat phase C to 80 ^° C. and stir into the combined phases A and B while homogenizing. Cool to about 40 ° C, stir in phase D and homogenize again.

Example 1 1: Use of VERB. (V) in a foot balm

WS 1%:

% Ingredient (INCI)

2.0 Ceteareth-6, Stearyl Alcohol

2.0 Ceteareth-25

5.0 Cetearyl ethylhexanoate

4.0 Cetyl Alcohol

4.0 glyceryl stearate

5.0 mineral oil

0.2 menthol

0.5 camphor

B 69.3 Aqua the. q.s. Preservative C 1, 0 Bisabolol

1, 0 tocopheryl acetate D 1, oily solution with about 5% VERB. (V)

5.0 Witch Hazel Extract

WS 5% o :! % Ingredient (INCI)

2.0 Ceteareth-6, Stearyl Alcohol

2.0 Ceteareth-25

5.0 Cetearyl ethylhexanoate

4.0 Cetyl Alcohol

4.0 glyceryl stearate

5.0 mineral oil

0.2 menthol

0.5 Camphor B 65.3 Aqua dem. q.s. preservative

1, 0 Bisabolol

1, 0 tocopheryl acetate

D 5.0 oily solution with approx. 5% verb. (V)

5.0 Witch Hazel Extract

Preparation: Heat the components of phases A and B separately to about 80 ^° C. Stir phase B into phase A while homogenizing. Cool with stirring to about 40 ⁰ C, add the phases C and D and briefly nachhomogenisieren. Cool to room temperature while stirring. Example 12: Use of VERB. (V) in a W / O emulsion with bisabolol

WS 1%:

% Ingredient (INCI)

6.0 PEG-7 Hydrogenated Castor OiI

8.0 Cetearyl ethylhexanoates

5.0 isopropyl myristate

15.0 mineral oil

0.3 mg stearate

0.3 Aluminum Stearate

2.0 PEG-45 / dodecyl glycol copolymer

B 5.0 glycerin

0.7 magnesium sulphates

55.6 Aqua the.

1, 0 oily solution with about 5% VERB. (V)

0.5 tocopheryl acetate

0.6 bisabolol

WS 5% o :! % Ingredient (INCI)

6.0 PEG-7 Hydrogenated Castor OiI

8.0 Cetearyl ethylhexanoates

5.0 isopropyl myristate

15.0 mineral oil

0.3 mg stearate

0.3 aluminum stearates

2.0 PEG-45 / dodecyl glycol copolymer

B 5.0 glycerin

0.7 magnesium sulphates

51, 6 Aqua the.

5.0 oily solution with about 5% VERB. (V)

0.5 tocopheryl acetate

Preparation: Heat phases A and B separately from each other to approx. 85 ° C. Stir phase B into phase A and homogenize. Cool with stirring to about 40 ⁰ C, add phase C and briefly homogenize again. Cool to room temperature while stirring. Compilation Formulations for Patent Keratin Binding Domain - Haircare Example 13: Foam Conditioner with Fixer

WS 1%

% Ingredient (INCI)

10.0 PVP / VA copolymer

0.2 Hydroxyethyl Cetyl Diammonium Phosphate

0.2 Ceteareth-25

0.5 Dimethicone Copolyol q.s. perfume oil

10.0 Alcohol

1, 0 oily solution with about 5% VERB. (V)

68.1 Aqua.

10.0 propane / butane

5%

% Ingredient (INCI)

A 10.0 PVP / VA copolymer

0.2 Hydroxyethyl Cetyl Diammonium Phosphate

0.2 Ceteareth-25

0.5 Dimethicone Copolyol q.s. perfume oil

10.0 Alcohol

5.0 oily solution with about 5% VERB. (V)

64.1 Aqua.

10.0 propane / butane

Preparation: Weigh the components of phase A together, stir until everything is dissolved and bottled.

Example 14: Foam conditioner

WS 1%

% Ingredient (INCI)

A 1, 0 Polyquaternium-4

0.5 hydroxyethyl cetyldimonium phosphates

1, 0 oily solution with about 5% VERB. (V) q.s. Perfume oil q.s. preservative

91, 5 Aqua the.

6.0 propanes / butanes

WS 5%% Ingredient (INCI)

A 1, 0 Polyquaternium-4

0.5 hydroxyethyl cetyldimonium phosphates

5.0 oily solution with about 5% VERB. (V) q.s. Perfume oil q.s. preservative

87.5 Aqua the.

6.0 propanes / butanes

Production: Weigh the components of phase A together, stir until everything is clearly dissolved and bottled.

Example 15: Foam conditioner

WS 1%

% Ingredient (INCI)

A 1, 0 Polyquaternium-1 1

0.5 hydroxyethyl cetyldimonium phosphates 1, 0 oily solution with ca. 5% VERB. (V) q.s. Perfume oil q.s. preservative

91, 5 Aqua the.

6.0 propanes / butanes WS 5%

% Ingredient (INCI)

1, 0 Polyquaternium-1 1

0.5 hydroxyethyl cetyldimonium phosphates

5.0 oily solution with about 5% VERB. (V) q.s. Perfume oil q.s. preservative

87.5 Aqua the.

6.0 propanes / butanes

Production: Weigh the components of phase A together, stir until everything is clearly dissolved and bottled.

Example 16: Styling foam

WS 1%

% Ingredient (INCI)

A 0.5 Laureth-4 q.s. perfume oil

B 77.3 Aqua the.

10.0 Polyquaternium-28 1, oily solution with approx. 5% VERB. (V)

0.5 dimethicone copolyol

0.2 Ceteareth-25

0.2 panthenol

0.1 PEG-25 PABA 0.2 hydroxyethylcellulose

C 10.0 HFC 152 A WS 5%

% Ingredient (INCI)

A 0.5 Laureth-4 q.s. perfume oil

B 73,3 Aqua the.

10.0 polyquaternium-28

5.0 oily solution with about 5% VERB. (V)

0.5 dimethicone copolyol

0.2 Ceteareth-25

0.2 panthenol

0.1 PEG-25 PABA

0.2 hydroxyethylcellulose

10.0 HFC 152 A

Preparation: Mix the components of phase A. Add the components of phase B one by one and dissolve. Fill with phase C.

Example 17: Styling foam

WS 1%

% Ingredient (INCI)

A 2.0 cocotrimony methosulfate q.s. perfume oil

B 78.5 Aqua the.

6,7 acrylates copolymer

0.6 AMP

1, 0 oily solution with about 5% VERB. (V)

0.5 dimethicone copolyol

0.2 Ceteareth-25

0.2 panthenol

0.1 PEG-25 PABA

0.2 hydroxyethylcellulose

C 10.0 HFC 152 A WS 5%

% Ingredient (INCI)

A 2.0 cocotrimony methosulfate q.s. perfume oil

B 74.5 Aqua the.

6,7 acrylates copolymer

0.6 AMP 5.0 oily solution with about 5% VERB. (V)

0.5 dimethicone copolyol

0.2 Ceteareth-25

0.2 panthenol

0.1 PEG-25 PABA 0.2 hydroxyethylcellulose

C 10.0 HFC 152 A

Preparation: Mix the components of phase A. Add the components of phase B one by one and dissolve. Fill with phase C.

Example 18: Styling foam

WS 1%% ingredient (INCI)

A 2.0 cocotrimony methosulfate q.s. perfume oil

B 7.70 Polyquaternium-44

1, 0 oily solution with about 5% VERB. (V) q.s. preservative

79.3 Aqua the.

C 10.0 propane / butane WS 5%

% Ingredient (INCI)

A 2.0 cocotrimony methosulfate q.s. perfume oil

B 7.70 Polyquaternium-44

5.0 oily solution with about 5% VERB. (V) q.s. Preservative 75.3 Aqua dem.

C 10.0 propane / butane

Preparation: Mix the components of phase A. Clear the components of phase B, then stir phase B into phase A. Adjust the pH to 6-7, fill with phase C.

Example 19: Styling foam

WS 1%% ingredient (INCI)

A 2.00 cocotrimonium methosulfate q.s. perfume oil

B 72,32 Aqua the.

2.00 VP / Acrylates / Lauryl Methacrylate Copolymer

0.53 AMP

1, 00 oily solution with about 5% VERB. (V)

0.20 Ceteareth-25 0.50 Panthenol

0.05 benzophenone-4

0.20 Amodimethicone, Cetrimonium Chloride, Trideceth-12

15.00 Alcohol

C 0.20 hydroxyethylcellulose

D 6,00 Propane / Butane WS 5%

% Ingredient (INCI)

A 2.00 cocotrimonium methosulfate q.s. perfume oil

B 68,32 Aqua the.

2.00 VP / Acrylates / Lauryl Methacrylate Copolymer

0.53 AMP 5.00 oily solution with approx. 5% VERB. (V)

0.20 Ceteareth-25

0.50 panthenol

0.05 benzophenone-4

0.20 Amodimethicone, Cetrimonium Chloride, Trideceth-12 15.00 Alcohol

C 0.20 hydroxyethylcellulose

D 6,00 Propane / Butane

Preparation: Mix the components of phase A. Add the components of phase B one by one and dissolve. Dissolve phase C in the mixture of A and B, then adjust the pH to 6-7. Fill with phase D.

Example 20: Styling foam

WS 1%

% Ingredient (INCI)

A 2.00 Cetrimonium Chloride q.s. perfume oil

B 67,85 Aqua the. 7.00 Polyquaternium-46

1, 00 oily solution with about 5% VERB. (V)

0.20 Ceteareth-25

0.50 panthenol

0.05 Benzophenone-4 0.20 Amodimethicone, Cetrimonium Chloride, Trideceth-12

15.00 Alcohol

C 0.20 hydroxyethylcellulose

D 6,00 Propane / Butane

WS 5%

% Ingredient (INCI)

A 2.00 Cetrimonium Chloride q.s. perfume oil

B 63,85 Aqua the.

7.00 Polyquaternium-46 5.00 oily solution with approx. 5% VERB. (V)

0.20 Ceteareth-25

0.50 panthenol

0.05 benzophenone-4

0.20 Amodimethicone, Cetrimonium Chloride, Trideceth-12 15.00 Alcohol

C 0.20 hydroxyethylcellulose

D 6,00 Propane / Butane Preparation: Mix the components of phase A. Add the components of phase B one by one and dissolve. Dissolve phase C in the mixture of A and B, then adjust the pH to 6-7. Fill with phase D.

Example 21: Styling foam

WS 1%

% Ingredient (INCI)

A q.s. PEG-40 Hydrogenated Castor OiI q.s. perfume oil

85.5 Aqua dem.

B 7.0 Sodium Polystyrene Sulfonate

1, 0 oily solution with about 5% VERB. (V)

0.5 Cetrimonium Bromide q.s. preservative

C 6.0 propane / butane

Styling foam

WS 5%% Ingredient (INCI)

A q.s. PEG-40 Hydrogenated Castor OiI q.s. perfume oil

81, 5 Aqua the.

B 7.0 Sodium Polystyrene Sulfonate

5.0 oily solution with about 5% VERB. (V)

0.5 Cetrimonium Bromide q.s. preservative

C 6.0 propane / butane

Preparation: Solubilize phase A. Weigh phase B into phase A and solve it clearly. Adjust the pH to 6-7, fill with phase C. Example 22: Styling foam

WS 1%

% Ingredient (INCI)

A q.s. PEG-40 Hydrogenated Castor OiI q.s. perfume oil

92.0 Aqua the.

B 0.5 polyquaternium-10

1, 0 oily solution with about 5% VERB. (V)

0.5 Cetrimonium Bromide q.s. preservative

C 6.0 propane / butane

WS 5%

% Ingredient (INCI)

A q.s. PEG-40 Hydrogenated Castor OiI q.s. Perfume oil 88.0 Aqua dem.

B 0.5 polyquaternium-10 5.0 oily solution with ca. 5% VERB. (V)

0.5 Cetrimonium Bromide q.s. preservative

C 6.0 propane / butane

Preparation: Solubilize phase A. Weigh phase B into phase A and solve it clearly. Adjust the pH to 6-7, fill with phase C. Example 23: Styling foam

WS 1%

% Ingredient (INCI)

A q.s. PEG-40 Hydrogenated Castor OiI q.s. perfume oil

82.5 Aqua the.

B 10.0 Polyquaternium-16

1, 0 oily solution with about 5% VERB. (V)

0.5 hydroxyethyl cetyldimonium phosphates q.s. preservative

C 6.0 propane / butane

WS 5%

% Ingredient (INCI)

A q.s. PEG-40 Hydrogenated Castor OiI q.s. Perfume oil 78.5 Aqua dem.

B 10.0 polyquaternium-16 5.0 oily solution with ca. 5% VERB. (V)

0.5 hydroxyethyl cetyldimonium phosphates q.s. preservative

C 6.0 propane / butane

Preparation: Solubilize phase A. Weigh phase B into phase A and solve it clearly. Adjust the pH to 6-7, fill with phase C. Example 24: Styling foam

WS 1%

% Ingredient (INCI)

A 2.0 cocotrimony methosulfate q.s. perfume oil

B 84.0 Aqua dem. 2.0 Chitosan

1, 0 oily solution with about 5% VERB. (V)

0.5 dimethicone copolyol

0.2 Ceteareth-25

0.2 Panthenol 0.1 PEG-25 PABA

C 10.0 HFC 152 A

WS 5%% Ingredient (INCI)

A 2.0 cocotrimony methosulfate q.s. perfume oil

B 80.0 Aqua dem.

2.0 Chitosan

5.0 oily solution with about 5% VERB. (V)

0.5 dimethicone copolyol

0.2 Ceteareth-25 0.2 Panthenol

0.1 PEG-25 PABA

C 10.0 HFC 152 A

Preparation: Mix the components of phase A. Add the components of phase B one by one and dissolve. Fill with phase C. Example 25: care shampoo

WS 1%

% Ingredient (INCI)

A 30.0 Sodium Laureth Sulfate

6.0 Sodium Cocoamphoacetate

6.0 Cocamidopropyl Betaine

3.0 Sodium Laureth Sulfate, Glycol Distearate, Cocamide MEA, Laureth-10 1, Oily solution with ca. 5% VERB. (V)

7.7 polyquaternium-44

2.0 Amodimethicone q.s. Perfume oil q.s. Preservative 1, 0 Sodium Chloride

43.3 Aqua the.

B q.s. Citric Acid

WS 5%

% Ingredient (INCI)

A 30.0 Sodium Laureth Sulfate

6.0 Sodium Cocoamphoacetate 6.0 Cocamidopropyl Betaine

3.0 Sodium Laureth Sulfate, Glycol Distearate, Cocamide MEA, Laureth-10

5.0 oily solution with about 5% VERB. (V)

7.7 polyquaternium-44

2.0 Amodimethicone q.s. Perfume oil q.s. preservative

1, 0 Sodium Chloride

39.3 Aqua the.

B q.s. Citric Acid

Preparation: Mix and dissolve the components of phase A. Adjust the pH to 6-7 with citric acid. Example 26: shower gel

WS 1%

% Ingredient (INCI)

A 40.0 Sodium Laureth Sulfate

5.0 decyl glucosides

5.0 Cocamidopropyl betaines

1, 0 oily solution with about 5% VERB. (V) 1, 0 Panthenol q.s. Perfume oil q.s. preservative

2.0 Sodium Chloride

46.0 Aqua the.

B q.s. Citric Acid

WS 5%

% Ingredient (INCI)

A 40.0 Sodium Laureth Sulfate

5.0 decyl glucosides

5.0 Cocamidopropyl betaines

5.0 oily solution with about 5% VERB. (V) 1, 0 Panthenol q.s. Perfume oil q.s. preservative

2.0 Sodium Chloride

42.0 Aqua the.

B q.s. Citric Acid

Preparation: Mix and dissolve the components of phase A. Adjust the pH to 6-7 with citric acid. Example 27: Shampoo

WS 1%

% Ingredient (INCI)

40.0 Sodium Laureth Sulfate

5.0 Sodium C12-15 Pareth-15 Sulfonates

5.0 Decyl Glucosides q.s. perfume oil

0.1 phytantriol

44.6 Aqua the.

1, 0 oily solution with about 5% VERB. (V)

0.3 polyquaternium-10

1, 0 panthenol q.s. preservative

1, 0 Laureth-3

2.0 Sodium Chloride

5%

% Ingredient (INCI)

40.0 Sodium Laureth Sulfate

5.0 Sodium C12-15 Pareth-15 Sulfonates

5.0 Decyl Glucosides q.s. perfume oil

0.1 phytantriol

40.6 Aqua the.

5.0 oily solution with about 5% VERB. (V)

0.3 polyquaternium-10

1, 0 panthenol q.s. preservative

1, 0 Laureth-3

2.0 Sodium Chloride

Preparation: Mix and dissolve the components of phase A. Adjust the pH to 6-7 with citric acid. Example 28: Shampoo

WS 1%

% Ingredient (INCI)

15.00 cocamidopropyl betaines

10.00 Disodium Cocoamphodiacetate

5.00 Polysorbate 20

5.00 decyl glucosides q.s. Perfume oil q.s. preservative

1, 00 oily solution with about 5% VERB. (V)

0.15 guar hydroxypropyltrimonium chlorides

2.00 laureth-3

58.00 Aqua the. q.s. Citric Acid

B 3.00 PEG-150 distearate

WS 5%

% Ingredient (INCI)

A 15.00 cocamidopropyl betaines

10.00 Disodium Cocoamphodiacetate

5.00 Polysorbate 20

5.00 decyl glucosides q.s. Perfume oil q.s. preservative

5.00 oily solution with about 5% VERB. (V)

0.15 guar hydroxypropyltrimonium chlorides

2.00 laureth-3

54.00 Aqua the. q.s. Citric Acid

B 3.00 PEG-150 distearate

Production: Weigh in the components of phase A and dissolve. Adjust the pH to 6-7. Add phase B and heat to approx. 50 ^° C. Cool to room temperature while stirring. Example 29: Moisturizing Body Care Cream

WS 1%

% Ingredient (INCI)

A 2.0 Ceteareth-25

2.0 Ceteareth-6, Stearyl Alcohol

3.0 Cetearyl ethylhexanoate

1, 0 Dimethicone 4.0 Cetearyl Alcohol

3.0 G lyceryl steate S E

5.0 mineral oil

4.0 Simmondsia Chinensis (Jojoba) Seed OiI

3.0 Mineral OiI, Lanolin Alcohol

B 5.0 Propylene Glycol

1, 0 oily solution with about 5% VERB. (V)

1, 0 panthenol

0.5 Mg Aluminum Silicate Q.s Preservative

65.5 Aqua the.

C q.s. perfume oil

D qs Citric Acid

WS 5%

% Ingredient (INCI)

A 2.0 Ceteareth-25 2.0 Ceteareth-6, Stearyl Alcohol

3.0 Cetearyl ethylhexanoate

1, 0 dimethicone

4.0 Cetearyl Alcohol

3.0 G lyceryl steate S E 5.0 Mineral OiI

4.0 Simmondsia Chinensis (Jojoba) Seed OiI

3.0 Mineral OiI, Lanolin Alcohol

B 5.0 Propylene glycol 5.0 oily solution with ca. 5% VERB. (V)

1, 0 panthenol

0.5 Mg Aluminum Silicate Q.s Preservative

61, 5 Aqua the.

C q.s. perfume oil

D q.s. Citric Acid

Preparation: Heat phases A and B separately to about 80 ^° C. Phase B prehomogenising briefly, then stir phase B into phase A and again homogenisieren.Abkühlen to about 40 ⁰ C, Phase C and homogenize again good. Adjust the pH to 6-7 with citric acid.

Example 30: Moisturizing Body Care Cream

WS 1%

% Ingredient (INCI)

6.0 PEG-7 Hydrogenated Castor OiI

10.0 Cetearyl ethylhexanoates

5.0 isopropyl myristate

7.0 Mineral OiI

0.5 Shea Butter (Butyrospermum Parkii)

0.5 Aluminum Stearate

0.5 mg stearate

0.2 bisabolol

0.7 Quaternium-18 hectorites

B 5.0 Dipropylene glycol

0.7 magnesium sulfates q.s. preservative

62.9 Aqua.

q.s. perfume oil

1, 0 oil solution with about 5% VERB. (V)

WS 5%

% Ingredient (INCI)

6.0 PEG-7 Hydrogenated Castor OiI

10.0 Cetearyl ethylhexanoates

5.0 isopropyl myristate

7.0 Mineral OiI

0.5 Shea Butter (Butyrospermum Parkii)

0.5 Aluminum Stearate

0.5 mg stearate

0.2 bisabolol

0.7 Quaternium-18 hectorites

B 5.0 Dipropylene glycol

0.7 magnesium sulfates q.s. preservative

58.9 Aqua.

q.s. perfume oil

5.0 oil solution with ca. 5% VERB. (V)

Preparation: Heat phases A and B separately to about 80 ^° C. Stir phase B into phase A and homogenize. Cool with stirring to about 40 ⁰ C, add phase C and homogenize again. Allow to cool to room temperature while stirring.

Example 31: Liquid Make-up - Type O / W

WS 1%

% Ingredient (INCI)

2.0 Ceteareth-6, Stearyl Alcohol

2.0 Ceteareth-25

6.0 glyceryl stearates

1, 0 Cetyl Alcohol

8.0 mineral OiI

7.0 cetearyl ethylhexanoate

0.2 dimethicone

B 3.0 Propylene glycol

1, 0 panthenol q.s. preservative

61, 9 Aqua the.

0.1 bisabolol

1, 0 oily solution with about 5% VERB. (V) q.s. perfume oil

D 5.7 C.I. 77 891, Titanium Dioxide

1, 1 Iron Oxides

WS 5%

% Ingredient (INCI)

2.0 Ceteareth-6, Stearyl Alcohol

2.0 Ceteareth-25

6.0 glyceryl stearates

1, 0 Cetyl Alcohol

8.0 mineral OiI

7.0 cetearyl ethylhexanoate

0.2 dimethicone

B 3.0 Propylene glycol

1, 0 panthenol q.s. preservative

57.9 Aqua the.

0.1 bisabolol

5.0 oily solution with about 5% VERB. (V) q.s. perfume oil

D 5.7 C.I. 77 891, Titanium Dioxide

1, 1 Iron Oxides

Preparation: The phases A and B separately to about 80 ⁰ C. Bring phase B into phase A and homogenize. Cool with stirring to about 40 ⁰ C, add phases C and D and thoroughly homogenize again. Allow to cool to room temperature while stirring.

Example 32:

In the following, dermocosmetics according to the invention are described, containing the VERB prepared according to example 1. (V). Said VERB. (V) is referred to in the following examples as VERB. (V). As a preferred compound of VERB. (V) 3,3'-Dihydroxyisorenieratin used. It is self-evident to the person skilled in the art that all other compounds of VERB. (V) prepared according to Example 1 and can be used in the preparations mentioned below. The named VERB. (V) is used as a solid. The following information is parts by weight.

Clear shampoo

Clear conditioner shampoo

Foam O / W emulsions

Conditioner Shampoo with pearlescent

Adjust pH to 6.0

Clear conditioner shampoo

Adjust pH to 6.0 Clear conditioner shampoo with volume effect

OW Sunscreen formulation

Hydro dispersion

Sticks

PIT emulsion

Gel Cream

OW Formulations self-tanner

Hydrodispersion self-tanner

Sticks

PIT emulsions self-tanner

oil gel

Example 33:

In the following formulations are cosmetic sunscreen formulations comprising a combination of at least one inorganic pigment, preferably zinc oxide and / or titanium dioxide and organic UV-A and UV-B filters and the VERB used according to Example 1. (V) described. 3,3'-Dihydroxyisorenieratin is preferred in the following examples as VERB. (V) used. The VERB. (V) is used in the following examples to represent all other VERBs described. (V) used. It is self-evident to the person skilled in the art that all other compounds of VERB. (V) prepared according to Example 1 and can be used in the preparations mentioned below.

The following formulations are prepared in a customary manner known to the person skilled in the art.

The content of VERB. (V) refers to 100%. The VERB. (V) can be used both in a pure form and as an oily solution. In the case of the oily solution, the content of oil must be equal to the content of VERB. (V) be adapted in the respective formulation.

65.20 water to the. Aqua the.

D 2.00 simulgel NS hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, squalane, polysorbate 60

2% VERB. (V) q.s. preservative

A 5.00 Uvinul N 539 T Octocrylene

2.00 Uvinul A Plus Diethylamino Hydroxybenzoyl Hexyl Benzoate

0.80 RyIo PG H Polyglyceryl Dimer Soyate

1, 00 Span 60 Sorbitan Stearate

0.50 vitamin E acetate tocopheryl acetate

3.00 Dracorin 100 SE Glyceryl Stearate, PEG-100 Stearate

1, 00 Cremophor CO 410 PEG-40 Hydrogenated Castor OiI

B 3.00 Z-COTE MAX Zinc Oxide (and) Diphenyl Capryl Methicone

1, 00 Cetiol SB 45 Butyrospermum Parkii (Shea Butter)

6.50 Finsolv TN C12-15 alkyl benzoates

C 5.00 Butylene Glycol Butylene Glycol

0.30 Keltrol Xanthan gum

0.10 Edeta BD Disodium EDTA

0.10 allantoin allantoin

66.70 water to the. Aqua the.

D 2.00 simulgel NS hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer, squalane, polysorbate 60

0.5% VERB. (V) q.s. preservative

5.00 T-Lite SF Titanium Dioxide, Alumina Hydrate, Dimethicone / Methicone Copolymer

6.00 Finsolv TN C12-15 alkyl benzoates

10.00 Uvinul MC 80 ethylhexyl methoxycinnamate

6.00 Miglyol 812 Caprylic / Capric Triglycerides

5.00 Arlacel P 135 PEG-30 dipolyhydroxystearates

2.00 Ganex V 216 PVP / hexadecene copolymer

2.00 Elfacos ST 9 PEG-45 / dodecyl glycol copolymer

B 3.00 1, 2-propylene glycol Care Propylene Glycol

0.10 Edeta BD Disodium EDTA

1, 00 magnesium sulfate 7-hydrate magnesium sulfates

59.40 water to the. Aqua the.

0.5% VERB. (V) q.s. preservative

copolymer

C 46.00 water to the. Aqua the.

D 5.00 1, 2-propylene glycol Care Propylene Glycol

0.50 cremophore A 25 ceteareth-25

0.05% VERB. (V)

20.00 ethanol 96% alcohol

A 1, 00 Uvinul A Plus diethylamino hydroxybenzoyl hexyl benzoate

1, 00 Tinosorb S bis-ethylhexyloxyphenol methoxyphenyl triazine

3.00 Uvinul MC 80 ethylhexyl methoxycinnamate

8.00 Miglyol 812 Caprylic / Capric Triglycerides

1, 50 Dow Corning 350 Fluid Dimethicone

3.00 Z-COTE MAX Titanium Dioxide, Alumina Hydrate, Dimethicone / Methicone Copolymer

3.00 Finsolv TN C12-15 alkyl benzoates

1, 00 Cremophor CO 40 PEG-40 Hydrogenated Castor OiI

B 2.00 Luvigel EM Caprylic / Capric Triglyceride, Sodium Acrylate Copolymer

C 54,80 water the. Aqua the.

D 15.00 Ethanol 96% Alcohol

5.00 1, 2-propylene glycol Care Propylene Glycol

0.50 cremophore A 25 ceteareth-25

1, 0% VERB. (V)

1, 00 vitamin E acetate tocopheryl acetate

0.20 bisabolol rac. bisabolol

Example 34

Determination of the antioxidative effect of 3,3'-dihydroxyisorenieratin in the peroxide inhibition test

Cumen was mixed in a closed vessel at 37 ⁰ C with a free radical generator. For this purpose, 5 ml of cumene were mixed with 4 ml of chlorobenzene and the reaction started with 1 ml of 0.45 M solution of 2,2'-azobis (2,4-dimethylvaleronitrile) (AMVN) in chlorobenzene. The reaction mixture was stirred well and tempered by a thermostat. As a result, the reaction yielded concentrations of 3.6 mol / L cumene and 45 mmol / L AMVN. The formation of cumene hydroperoxides was determined by High Preformance Liquid Chromatography (HPLC) by removing 50 μl samples from the vessel through a septum and a mobile phase of hexane and isopropanol in a volume ratio of 99 to 1 and a flow rate of 2 ml was passed over a silica gel column per minute. The column had the dimensions: 150 x 6.0 mm, the grain size of the column packing was 5 microns. Cumen hydroperoxide resulting from the reaction and a byproduct were detected at a wavelength of 254 nm and a retention time of 2.285 and 2.405 minutes, respectively. The area of these double peaks was plotted against the reaction time in minutes, whereby a calibration line of the test system was obtained. Subsequently, further tests were carried out with different 3,3'-dihydroxyisomers in concentrations in the reaction mixture and the calibration line was used to determine the delay in cumene hydroperoxide formation at different 3,3'-dihydroxyisorenieratin and other antioxidant concentrations in minutes. The reaction was stirred at delay 2 ^* 10 ^"4 mol / l, 4 ^{* 10" 4} mol / l, 1 ^* 10 ³ mol / l and 2 ^* 10 ^"3 mol / l 3,3' Dihydroxyisorenieratene measured. For each of the measured Antioxidant concentrations, the time of complete inhibition of the reaction was determined by

Intersection of the regression line calculated. The calculated inhibition times were then plotted against the respective antioxidant concentration and the associated regression line determined. These lines were used to compare the antioxidant capabilities of the antioxidants. A high slope of the straight line indicates a high anti-oxidative effect.

Example 35

Determination of the antioxidative effect of 3,3'-dihydroxyisorenieratin in the oxygen partial pressure test.

A reactive system of 5 ml of cumene with 4 ml of chlorobenzene and 1 ml of 0.45 M solution of 2,2'-azobis (2,4-dimethylvaleronitrile) (AMVN) in chlorobenzene was provided with various antioxidants and an oxygen partial pressure of 150 Torr exposed. As a result, the reaction yielded concentrations of 3.6 mol / L cumene and 45 mmol / L AMVN plus variable concentrations of antioxidant. During the course of the reaction, the decrease in the oxygen partial pressure relative to a reference vessel was measured. The differential pressure sensor was the MKS Baratron (type 223B) and the absolute pressure transducer was the MKS device

Baratron (type 122A) used. The values were read out digitally by the MKS Type PDR-D-1 Power Supply Digital Readout device. For better comparability, the curves were normalized to the normal pressure of 760 Torr, and then the slope of the curve between 50 and 70 minutes was determined and multiplied by the factor 665.7 (M ^* min) / (s ^* Torr) by the slope in oxidation rates (-d [C "2] / dt ^* 10" ⁸ M / s). A low oxidation rate corresponds to a high antioxidant effect.

nb = not determinable ng = not measured

Example 36

Comparison of the oxidation rates of various carotenoids and phenolic substances.

A reactive system of 5 ml of cumene with 4 ml of chlorobenzene and 1 ml of 0.45 M solution of 2,2'-azobis (2,4-dimethylvaleronitrile) (AMVN) in chlorobenzene was provided with various antioxidants and an oxygen partial pressure of 150 Torr exposed. Thus, concentrations of 3.6 mol / l cumene and 45 mmol / l AMVN plus antioxidant in a concentration of 2.00 ^* 10 ^"5 and 4:00 ^* 10" ⁵ were obtained for the reaction. During the course of the reaction, the decrease in the oxygen partial pressure relative to a reference vessel was measured. The differential pressure transducer used was the MKS Baratron (type 223B) and the MKS Baratron (type 122A) absolute pressure transducer. The values were read out digitally by the MKS Type PDR-D-1 Power Supply Digital Readout device. For better comparability, the traces were normalized to the normal pressure of 760 Torr and then the slope of the curve was determined between 50 and 70 minutes and multiplied by the factor 665.7 (M ^* min) / (s ^* Torr) to reflect the slope in oxidation rates (-d [C "2] / dt ^* 10" ⁸ M / s). A low oxidation rate corresponds to a high antioxidant effect. The abbreviation BHT is given in the table for 4-methyl-2,6-di-tert-butylphenol. The abbreviation BHT-carotenoid is given in the table for 3,3'-dihydroxy-2,2 ', 4,4'-tetra tert-butylisorenieratin The abbreviation DHIR is in the table for the 3,3'-dihydroxyisorenieratin.

The abbreviation DB-BHT carotenoid is in the table for the di-benzoyl BHT carotenoid.

Claims

claims:

1. antioxidant containing at least one isorenieratin compound (I) of general formula (I)

wherein

R ¹ = H or an easily cleavable protecting group R ² to R ⁴ are the same or different and a Ci to C3 independently

Alkyl group is.

2. antioxidant, according to claim 1, containing at least one Isorenieratin compound (I) wherein R ¹ = H and R ² to R ⁴ = methyl are (3,3'-Dihydroxyisorenieratin)

3. antioxidant containing at least one isorenieratin compound (I) according to claims 1 or 2 and isorenieratin-3,3'-dichinone (II)

or 2,2 ', 4,4'-tetra-tert-butylisorenieratin-3,3'-dichinone (III)

or 3,3'-dihydroxy-2,2 ', 4,4'-tetra-tert-butylisorenieratin (IV)

or mixtures of these.

4. Mixtures (M1) containing at least one isorenieratin compound (I) according to claims 1 or 2 and isoridin-3,3'-dichinone (II) or 2,2 ', 4,4'-tetra-tert-butylisorenieratin -3,3'-dichinone (IM) or mixtures of these.

5. Mixtures (M2) containing 3,3'-dihydroxy-2,2 ', 4,4'-tetra-tert-butylisorenieratin (IV) and at least one isorenieratin compound (I) according to claims 1 or 2 or a Mixture (M1) according to claim 4.

6. Preparations containing at least one isorenieratin compound (I) according to claims 1 or 2 or isorenieratin-3,3'-dichinone (II) or 2,2 ', 4,4'-tetra-tert-butylisorenieratin-3, 3'-Dichinone (IM) or 3,3'-dihydroxy-2,2 ', 4,4'-tetra-tert-butylisorenieratin (IV) (Compounds V) or mixtures thereof.

7. Dermocosmetics, pharmaceuticals, food or feed containing at least one of the compounds (V) or prepared using at least one preparation according to claim 6.

8. solids or liquids or mixtures thereof containing at least one of the compounds (V).

9. Colorant containing isorenieratin-3,3'-dichinone (II) or 2,2 ', 4,4'-tetra-tert-butylisorenieratin-3,3'-dichinon (IM) or 3,3'-dihydroxy- 2,2 ', 4,4'-tetra-tert-butylisorenieratin (IV) or mixtures (M1) or (M2).

10. colorant containing at least one of the compounds (V) in the form of H or J aggregates.

1 1. dermocosmetics, pharmaceuticals, food or feed containing at least one colorant according to claims 9 or 10.

12. solids or liquids or mixtures thereof containing at least one colorant according to claims 9 or 10.

13. vesicles containing at least one of the compounds (V).

14. dermocosmetics, pharmaceuticals, food or feed containing vesicles according to claim 13.

15. Solids or liquids or mixtures thereof containing vesicles according to claim 13.

16. Carotenoid formulations containing at least one of the compounds (V).

17. Preparations containing at least one carotenoid formulation according to claim 16 or prepared using at least one preparation according to claim 6.

18. dermocosmetics, pharmaceuticals, food or feed containing at least one carotenoid formulation according to claim 16 or prepared using at least one preparation according to claim 6.

19. Gelatin capsules containing at least one carotenoid formulation according to claim 16 or prepared using at least one carotenoid formulation according to claim 16.

20. Antioxidants, mixtures (M1) or (M2), preparations, colorants, vesicles, carotenoid formulations, dermocosmetics, pharmaceuticals, food or feed, gelatin capsules or other solids or liquids or mixtures thereof, containing at least one of the compounds (V) in micronized form.

21. A process for the preparation of antioxidants, mixtures (M1) or (M2), preparations, colorants, vesicles, carotenoid formulations, dermocosmetics, pharmaceuticals, food or feed, gelatin capsules or other solids or liquids or mixtures thereof according to at least one of

Claims 1 to 19, characterized in that at least one of the compounds (V), antioxidants, mixtures (M1) or (M2), preparations, colorants, vesicles, or carotenoid formulations, according to at least one of claims 1 to 6, 9, 10, 13, 16 or 17 is used during their manufacture.

22. Use of at least one of the compounds (V), antioxidants, mixtures (M1) or (M2), preparations, colorants, vesicles or carotenoid formulations, according to claims 1 to 6, 9, 10, 13, 16 or 17, for the production of antioxidants, mixtures, preparations, colorants, vesicles, carotenoid formulations, dermocosmetics, pharmaceuticals, food or feed,

Gelatin capsules or other solids or liquids or mixtures thereof.