TW200816932A - Functional chewy food and process for production and use thereof - Google Patents

Functional chewy food and process for production and use thereof Download PDF

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Publication number
TW200816932A
TW200816932A TW096100689A TW96100689A TW200816932A TW 200816932 A TW200816932 A TW 200816932A TW 096100689 A TW096100689 A TW 096100689A TW 96100689 A TW96100689 A TW 96100689A TW 200816932 A TW200816932 A TW 200816932A
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Taiwan
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functional
chew
chewing
acid
extract
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TW096100689A
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Chinese (zh)
Inventor
Fumio Okumura
Kazuya Kubo
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Meiji Pharmaceutical Co Ltd
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Priority claimed from PCT/JP2006/320478 external-priority patent/WO2007043656A1/en
Application filed by Meiji Pharmaceutical Co Ltd filed Critical Meiji Pharmaceutical Co Ltd
Publication of TW200816932A publication Critical patent/TW200816932A/en

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Abstract

A masticatory material, which is produced by tabletting or granulating starting materials including prolamins, wheat gluten and a functional material, shows elasticity and spreadability when impregnated with saliva in mastication. Moreover, it is edible and has such a constitution that it can be masticated over a longer time than gummy candies. Thus, this masticatory material has various mastication times longer than that of gummy candies and, moreover, makes it possible to take a sufficient amount of a functional material independently from the properties (water-solubility, etc.) thereof.

Description

200816932 (1) 九、發明說明 【發明所屬之技術領域】 本發明係關於含有具有益於維持或回復健康生理作用 及疾病治療效果之機能性成分,且可強化咀嚼力之機能性 " 咀嚼物及其製造方法與使用方法。 【先前技術】 Φ 近年來於日本地區,伴隨著飮食內容與生活方式之歐 美化,糖尿病、高血壓、高血脂等與生活習慣有關疾病正 增加中,而接連著少子高齡化社會的到來,國民對健康的 意識逐漸提高,/自己守護自己的健康」此一自我照護的 觀念普及化結果,許多機能性食品,亦即健康食品紛紛投 入市場,且其市場規模目前已達到1兆日圓。而由於加工 食品的增加及口味變化等,'在低年齡層其攝取不需大咀嚼 力且柔軟的食品及含較多糖分的零食及果汁類的傾向增強 # 的結果,齲齒的增加及齒幹減弱化的情形也愈佳嚴重。相 反地,高齡者的牙齒及齒幹等由於口腔內疾病而使咀嚼力 減退,依賴流體食物及經腸劑(enteral agent)等之案例增 加的結果,消化器官及舌頭的機能減退,且使語言能力喪 ~ 失及體力低下,最終演變爲老人癡呆及終日臥床等問題。 於上述之社會情勢下,希望以改善咀嚼機能且回復健 康爲目的,而開發了許多混合許多種機能性成分,由軟糖 所構成之咀嚼物(參照專利文件1 )。亦開發了混合木糖醇 及兒茶素等抗齲齒成分的機能性口香糖。進而,亦開發了 -4 - 200816932 (2) 經小麥麩質分劃之麥膠蛋白分劃物,及於含水狀態下與小 麥麩質進行混捏而製造之可食性機能性咀嚼物(參照專利 文件2)。 專利文件1 :日本特開2 0 〇 2 - 8 5 0 0 8號公報 • 專利文件2 ··日本特開2 0 0 6 - 1 0 9 7 5 1號公報 【發明內容】 Φ 然而,於軟糖類的咀嚼物,咀嚼1粒約4g的軟糖時 ’大約會在1分鐘以內即溶解,即使一次攝取3粒,咀嚼 時間一大約爲2分鐘,會出現做爲咀嚼物其咀嚼時間之長 度難以稱之爲足夠的問題。另外,以小麥麩質用爲橡膠基 質之可食性橡膠,於含水狀態下混捏成濕塊物,會有咀嚼 性易產生經時劣化的問題。進而於混合機能性成分之口香 糖,因橡膠基質爲合成高分子而不具有可食性,出現咀嚼 後拋棄而有污染環境的問題,同時機能性成分亦與橡膠基 # 質一同被拋棄,而產生無法充分有效利用機能性成分的問 題。 反之,麥膠蛋白分劃物於含水狀態下與小麥麩質進行 混捏而製造之機能性咀嚼物,因其水分含量約在25重量 .. %之多量含水而易發霉,必須施以糖衣及塗層膜等防霉處 理。這類含水量高之機能性咀嚼物因無法混合易受水分影 響之乳酸菌及酵素,會出現機能性成分有所限制之問題。 進而,將該機能性咀嚼物於4(TC下保存1個月後,咀嚼之 彈力明顯變低。進而於開始咀嚼後超過1 5分鐘即不再濕 -5- 200816932 (3) 濡之機能性咀嚼物,對於人們,例如高齡者、孩童及婦女 ,因難以吞嚥而有難以攝取非水溶性之固體狀機能成分之 問題。自濕塊物而製造機能性咀嚼物時,因於混捏、壓延 時需要極大壓力,無法使用一般的攪拌機及壓延機,需要 " 特殊製造裝備而有使製造成本大幅增高的問題。 \ 本發明有鑑於上述現狀,亦即在使軟糖咀嚼時間增長 ,且具有不同咀嚼時間長度的同時,並以提供防止於咀嚼 φ 後丟棄,具有益於維持或回復健康之生理作用及疾病治療 效果之機能性成分,且不依賴這些成分之水溶性等性質, 而可攝取該機能性咀嚼物及其製造方法與使用方法爲目的 〇 本發明之發明者們爲解決上述問題進行專心檢討後, 發現添加、混合醇溶蛋白類、小麥麩質或/及與多酚類之 混合物等多種機能性成分,藉由將其錠劑化或顆粒化,而 可於咀嚼時含唾液後而具有適度之彈性與集合性,於強化 # 咀嚼力同時,可確實攝取可食性之機能性成分,進而得到 用做無須水分即可服用之製劑之機能性咀嚼物,而完成本 發明。 亦即,本發明申請專利範圍第1項係關於一種具功能 β 性之咀嚼物,其係以醇溶蛋白類、小麥麩質及功能性材料 爲原料將其錠劑化或顆粒化,於咀嚼時含唾液後產生彈性 與伸展性,較具可食性之軟糖更加延長其咀嚼時間而構成 〇 本發明申請專利範圍第2項係如申請專利範圍第1項 -6- 200816932 (4) 之具功能性之咀嚼物,其中醇溶蛋白類與小麥麩質之比例 係以重量比爲8 : 2〜2 ·· 8所構成。 本發明申請專利範圍第3項係關於一種具功能性之咀 嚼物,其係以醇溶蛋白類、多酚類及功能性材料爲原料將 ' 其錠劑化或顆粒化,於咀嚼時含唾液後產生彈性與伸展性 - ,較具可食性之軟糖更加延長其咀嚼時間,同時藉由多酚 類提升其彈性及伸展性而構成。 φ 本發明申請專利範圍第4項係關於一種具功能性之咀 嚼物,其係以醇溶蛋白類、小麥麩質、多酚類及功能性材 料爲原料將其錠劑化或顆粒化,於咀嚼時含唾液後產生彈 性與伸展性,較具可食性之軟糖更加延長其咀嚼時間,同 時藉由多酚類提升其彈性及伸展性而構成。 本發明申請專利範圍第5項係如申請專利範圍第4項 之具功能性之咀嚼物,其中醇溶蛋白類與小麥麩質之比例 係以重量比爲9 · 9 : 0 · 1〜2 : 8所構成。 • 本發明申請專利範圍第6項係如申請專利範圍第3或 4項之具功能性之咀嚼物,其中係由相對於醇溶蛋白類與 小麥鍵質合計量混合入1〜2 0 %之多酣類所組成。 本發明申請專利範圍第7項係如申請專利範圍第1、3 ‘ ‘ 或4項之具功能性之咀嚼物,其中醇溶蛋白類係由小麥的 麥膠蛋白、玉米的玉米蛋白、大麥的大麥蛋白中所選出之 至少一種所組成。 本發明申請專利範圍第8項係如申請專利範圍第1、3 或4項之具功能性之咀嚼物,其中功能性材料係自包含茶 200816932 (5) 葉兒茶素、沒食子兒茶素沒食子酸脂、蔔萄籽花青素原、 法國海岸松樹皮萃取物之多酚類、芝麻木聚糖類、來自紅 球藻之還原蝦紅素' γ-氨基丁酸、降壓胜肽、木糖醇、乳 香萃取物、蜂膠、海蘿聚糖、肉宣蔻及艾草之藥材萃取物 " 類、蘑菇、桑黃及猴頭菇之菇類萃取物類、岩藻依聚糖、 - 經加熱處理之乳酸菌菌體粉末、乳鐵蛋白、異黃酮、銀杏 葉萃取物、小長春花萃取物、磷脂醯絲胺酸、花生油酸、 φ 來自魚類的ΕΡΑ及DHA高度不飽和脂肪酸、辣椒粉末、 烯酮素、辣椒素酯、輔酶Q-10、硫辛酸、肉鹼鹽酸鹽、 根橘萃取物、五層龍萃取物、武靴葉萃取物、四季豆萃取 物、桑葉萃取物、維他命類、黃綠色蔬菜萃取物類、蜂王 漿、鈣化合物•鎂化合物·酵母鋅、鐵劑之礦物質類、滋 養強壯用藥材萃取物類、腦醯胺、玻尿酸、半胱胺酸、腕 胺酸、香蕈萃取物、銅葉綠素鈉、鐵葉綠素鈉、乳酸菌類 、菊糖、果寡糖、半乳糖寡糖、木寡糖、尼古丁、咖啡因 • 、茶胺酸中選用至少一種以上而組成。 本發明申請專利範圍第9項係如申請專利範圍第1、3 或4項之具功能性之咀嚼物,其中功能性材料係自包含蘋 果花青素原、果露萃取物、藍莓萃取物之多酣類、來自黑 豆的青色素配糖體、薑黃素、四氫薑黃素、甘蔗原素、二 十八烷醇、膠原蛋白、植酸、阿斯匹靈、乙醯胺酸、dl-馬 來酸氯菲安明、磷酸二氫可待因、dl-鹽酸甲基麻黃鹼、檸 檬酸替培匹啶、氯化溶菌酶、美遠志流浸膏、咖啡因、烯 丙基異丙基乙醯脲、十六烷基氯化砒啶、鹽酸氯己碇、甲 -8- 200816932 (6) 酚磺酸鉀、山櫻樹皮、甘草、1-薄荷醇、奧磺酸鈉中選用 至少一種以上而組成。 本發明申請專利範圍第1 0項係如申請專利範圍第3 或4項之具功能性之咀嚼物,其中多酚類係自兒茶素類、 " 沒食子兒茶素沒食子酸脂、花青素原、花青素、黃酮醇、 二 異黃酮、芝麻素、槲黃素、薑黃素、柿單寧中選用至少一 種而組成。 φ. 本發明申請專利範圍第11項係如申請專利範圍第1、 3或4項之具功能性之咀嚼物,其係混合1〜40%之蛋白質 分解酵素劑而組成。 本發明申請專利範圍第1 2項係如申請專利範圍第1 1 項之具功能性之咀嚼物,其中蛋白質分解酵素劑係由選自 絲狀真菌、細菌、擔子菌、放射菌及植物來源之蛋白質分 解酵素而組成。 本發明申請專利範圍第1 3項係如申請專利範圍第1、 Φ 3或4項之具功能性之咀嚼物,其係混合5〜40%之助崩解 劑而組成。 本發明申請專利範圍第1 4項係如申請專利範圍第1 3 項之具功能性之咀嚼物,其中助崩解劑係由選自明膠、酪 蛋白鈉、酪蛋白鈣及膠原蛋白之蛋白質,或角叉菜膠、三 仙膠、結冷膠、黃耆膠、洋菜、羥甲基纖維素鈉、羥甲基 纖維素鈣、海藻酸鈉之多醣類,聚乙烯聚略院酮、脂肪酸 甘油酯而組成。 因此根據本發明申請專利範圍第1項,以醇溶蛋白類 -9- 200816932 (7) 、小麥麩質及功能性材料爲原料將其錠劑化或顆粒化,因 於咀嚼時含唾液後產生彈性與伸展性,可較具可食性之軟 糖有更長的、各種時間長度的咀嚼時間。另外因做爲原料 之醇溶蛋白類、小麥麩質及功能性材料具有可食性,而可 '不仰賴功能性材料之水溶性等性質而攝取充分的含有功能 ~ 性成分之功能性材料,期望維持及增進健康或回復健康同 時,亦可防止如口香糖般之咀嚼後拋棄,且可抑制環境物 φ 污染。進而,咀嚼功能性咀嚼物之後吞嚥時,因可藉由消 化道完全加以消化,不僅可確實地吸收功能性材料,期望 維持及增進健康或回復健康,更可進行疾病之治療。進而 因該功能性咀嚼物具有可食性,亦即適用爲無需水分即可 服用之製劑。 本發明所使用之小麥麩質,係稱爲活性麩質或維生麩 質之粉末狀小麥蛋白,其全體之約八成係由分子量爲約20 萬〜數百萬之麥谷蛋白,及分子量爲約3萬〜8萬之麥膠蛋 Φ 白所組成。 根據本發明申請專利範圍第3項,以醇溶蛋白類、多 酚類及功能性材料爲原料將其錠劑化或顆粒化,於咀嚼時 - 故 , 含唾液後產生彈性與伸展性,同時因藉由多酚類提升其彈 性及伸展性,而較具可食性之軟糖有更長的、各種時間長 度的咀嚼時間。另外因做爲原料之醇溶蛋白類、多酚類及 功能性材料具有可食性,而可不仰賴功能性材料之水溶性 等性質,而攝取充分的含有功能性成分之功能性材料,期 望維持及增進健康或回復健康同時,亦可防止如口香糖般 -10- 200816932 (8) 之咀嚼後拋棄,且可抑制環境物污染。進而,咀嚼功能性 咀嚼物之後吞嚥時,因可藉由消化道完全加以消化,不僅 可確實地吸收功能性材料.,期望維持及增進健康或回復健 康,更可進行疾病之治療。進而因該功能性咀嚼物具有可 1 食性,亦即適用爲無需水分即可服用之製劑。 二 根據本發明申請專利範圍第4項,以醇溶蛋白類、小 麥麩質、多酚類及功能性材料爲原料將其錠劑化或顆粒化 φ ,於咀嚼時含唾液後產生彈性與伸展性,同時因藉由多酚 類提升其彈性及伸展性,而較具可食性之軟糖有更長的、 各種時間長度的咀嚼時間。另外因做爲原料之醇溶蛋白類 、多酚類及功能性材料具有可食性,而可不仰賴功能性材 料之水溶性等性質,而攝取充分的含有功能性成分之功能 性材料,期望維持及增進健康或回復健康同時,亦可防止 如口香糖般之咀嚼後拋棄,且可抑制環境物污染。進而, 咀嚼功能性咀嚼物之後吞嚥時,因可藉由消化道完全加以 φ 消化,不僅可確實地吸收功能性材料,期望維持及增進健 康或回復健康,更可進行疾病之治療。進而因該功能性咀 嚼物具有可食性,亦即適用爲無需水分即可服用之製劑。 根據本發明申請專利範圍第1、3、4項,獲得錠劑化 ^ 或顆粒化之功能性咀嚼物時,可將原料粉末直接進行打錠 ,或將原料粉末進行乾式造粒後所得之顆粒再進行打錠, 抑或使用將原料粉末藉由流動層造粒乾燥法等濕式造粒法 進行造粒,於乾燥後再進行打錠等於製造醫藥品及健康食 品時所常用之步驟,藉由進行錠劑化或顆粒化而可得到水 -11 - 200816932 (9) 分含量少之功能性咀嚼物。因此與自濕塊物形成水分含量 高之功能性咀嚼物相異,於水分含量少的本發明之功能性 咀嚼物,不需要藉由糖衣及薄膜包覆之防霉處理,切不需 混捏•壓延等特殊設備,因其係藉由泛用性高之造粒•乾 • 燥•打錠而製造,亦可大幅減低製造成本。 \ 本發明之水分含量少的功能性咀嚼物,可使用醫藥品 業界及健康食品業界所泛用之造粒機·乾燥機•打錠機等 φ 設備而製造爲錠劑及顆粒。 製造水分含量少的功能性咀嚼物時,於乾試造粒法中 ,無須加水,將以混合之粉末藉由乾式造粒機進行造粒而 製造顆粒,於製造錠劑時再將該顆粒進行打錠。濕式造粒 法中之流動層造粒乾燥法,於原料粉末上以α化之澱粉等 連接水溶液進行噴霧,再製造乾燥顆粒,於製造錠劑時再 將該顆粒進行打錠。另外,因麥膠蛋白含水時會變爲黏稠 而產生黏著性,於濕式造粒法不易清潔製造設備,也因此 φ 以將無需使用水做爲結合液之乾試造粒法,做爲本發明之 功能性咀嚼物之造粒法爲特佳。相反地,製造由濕塊物所 構成的水分含量高之功能性咀嚼物時,加入1 5〜25 %的水 於麥膠蛋白等原料粉末再進行混捏時,因爲濕塊物變得極 ' “ 爲黏稠,造成混捏時的負擔,而需要如同製造口香糖時所 使用之大型強力的捏和機。進而爲將這些濕塊物拉伸爲薄 膜再進行裁斷,需要如同製造口香糖時所使用之2〜3段的 壓延滾筒與裁斷滾筒等特殊設備。另外,製造將由濕塊物 所構成的水分含量高之功能性咀嚼物進行熱風乾燥,再進 -12- 200816932 (10) 行破碎後所得之顆粒進行打錠而製造錠劑時,因濕塊物具 高黏稠性而須進行長時間的乾燥,同時,因所得顆粒過硬 而難以而於打錠時成形性不佳,難以有效率地製造錠劑, 當然大幅提升製造成本。將由濕塊物所構成的水分含量高 ' 之功能性咀嚼物進行冷凍乾燥時,需要乾燥2天以上的長 \ 時間,且將述十萬個一片約1 0mm板狀的小濕塊物收納於 冷凍乾燥機中,需要極爲繁雜之操做,與可確保每日產量 φ 爲100萬錠以上之本發明的製造方法相比,製造成本顯著 增加。 本申請案因於水分活性低之條件下錠劑化或顆粒化, 而可混合易受水分影響的乳酸菌及酵素。不溶於水的固體 狀功能性成分,例如混合白雲石等無機化合物之配方時, 將醇溶蛋白/小麥麩質之基材比例及多酚類之混合量,調 整爲數分鐘到1 0分鐘的咀嚼時間程度,或藉由細微地調 整咀嚼物重量每一錠3 00〜400mg,因變爲易於吞嚥,而可 • 確實且充分地攝取咀嚼物中所含之功能性成分。 如同本發明申請專利範圍第2項,於申請專利範圍第 1項中,將醇溶蛋白類與小麥麩質之比例係以重量比爲8 :2〜2 : 8構成時,增長適合之咀嚼時間及增加咀嚼次數, ^ 同時藉由其可食性,不會拋棄功能性材料且可充分攝取, 而可期望維持及增進健康或回復健康。藉由完全消化功能 性咀嚼物而可確實地吸收,不僅期望維持及增進健康或回 . 復健康,更可更適切地進行疾病之治療。醇溶蛋白類與小 麥麩質之比例以重量比爲8 : 2時,小麥麩質的比例較此 -13- 200816932 (11) 比例爲少時,因彈性變弱且咀嚼時間變短而不佳。醇溶蛋 白類與小麥麩質之比例以重量比爲2 : 8時,小麥麩質的 比例較此比例爲多時,因伸展性變爲極小,無法充分變爲 口香糖般的口感同時成形性變差且錠劑硬度變低,不易使 ” 用而不佳。爲確保本發明之功能性之咀嚼物其咀嚼口感的 ^ 良好度,醇溶蛋白類與小麥麩質之混合基材其最小混合量 以40重量%左右爲佳。 φ 如同本發明申請專利範圍第5項,於申請專利範圍第 4項中,將醇溶蛋白類與小麥麩質之比例係以重量比爲 9.9 : 0.1〜2 : 8構成時,增長適合之咀嚼時間及增加咀嚼 次數,同時藉由其可食性,不會拋棄功能性材料且可充分 攝取,而可期望維持及增進健康或回復健康。藉由完全消 化功能性咀嚼物而可確實地吸收,不僅期望維持及增進健 康或回復健康,更可更適切地進行疾病之治療。醇溶蛋白 類與小麥麩質之比例以重量比爲2 : 8時,小麥麩質的比 φ 例較此比例爲多時,因伸展性變爲極小,無法充分變爲口 香糖般的口感同時成形性變差且錠劑硬度變低,不易使用 而不佳。爲確保本發明之功能性之咀嚼物其咀嚼口感的良 好度,醇溶蛋白類與小麥麩質之混合基材其最小混合量以 ' 3 0重量%左右爲佳。 如同本發明申請專利範圍第6項,於申請專利範圍第 3、4項中,由相對於醇溶蛋白類與小麥麩質合計量混合入 1〜2 0%之多酚類時,充分增長咀嚼時間及增加咀嚼次數, 同時因藉由其可食性,不會拋棄功能性材料且可充分攝取 -14- 200816932 (12) ,而可期望維持及增進健康或回復健康。 能性咀嚼物而可確實地吸收,不僅期望維 回復健康,更可更適切地進行疾病之治療 小於1 %時,因彈性變弱且咀嚼時間變短 ; 多酚類之比例大於20%時則會增加苦味, • 不佳。 如同本發明申請專利範圍第7項,於 φ 1、3、4項中,醇溶蛋白類係由小麥的麥 玉米蛋白、大麥的大麥蛋白中所選出之至 ,增長適合之咀嚼時間及增加咀嚼次數, 性,不會拋棄功能性材料且可充分攝取, 增進健康或回復健康。藉由完全消化功能 實地吸收,不僅期望維持及增進健康或回 適切地進行疾病之治療。醇溶蛋白類中, 等蛋白質亦佳,但以小麥的麥膠蛋白爲最 • ,且因於製錠時玉米的玉米蛋白較大麥的 故以使用小麥的麥膠蛋白爲最佳。200816932 (1) IX. Description of the Invention [Technical Fields of the Invention] The present invention relates to a functional ingredient containing a functional ingredient which is beneficial for maintaining or restoring a healthy physiological action and a disease treatment effect, and which can enhance chewing force "chew And its manufacturing method and method of use. [Prior Art] Φ In recent years, in Japan, with the European and American food and lifestyle, diabetes, high blood pressure, high blood fat and other lifestyle-related diseases are increasing, and the arrival of the younger ageing society is coming. The national awareness of health has gradually increased, and they have guarded their own health. As a result of the popularization of self-care, many functional foods, namely healthy foods, have been put on the market, and its market size has now reached 1 trillion yen. As a result of the increase in processed foods and changes in taste, 'the increase in dental caries and the dryness of the teeth in the lower age group without the need for large chewing and soft foods and snacks and juices containing more polysaccharides. The weakening situation is also getting better and worse. On the contrary, the teeth and the trunk of the elderly have decreased chewing ability due to diseases in the oral cavity, and the results of the increase in the case of fluid foods and enteral agents, the function of the digestive organs and the tongue are reduced, and the language is made. The ability to lose ~ lost physical strength, and eventually evolved into problems such as dementia in the elderly and bed rest. Under the above-mentioned social situation, it is hoped that a lot of functional ingredients, a chew composed of soft candy, have been developed for the purpose of improving chewing function and restoring health (refer to Patent Document 1). Functional chewing gum mixed with anti-caries ingredients such as xylitol and catechin has also been developed. Further, 4 - 200816932 (2) a wheat gluten-divided gliadin fraction and an edible functional chew made by kneading with wheat gluten under water conditions have been developed (refer to the patent document). 2). Patent Document 1: Japanese Patent Laid-Open No. 2 0 〇 2 - 8 5 0 0 8 • Patent Document 2 • Japanese Special Open 2 0 0 6 - 1 0 9 7 5 1 [Invention] Φ However, in soft Sugar chews, when chewing a capsule of about 4g of soft candy, will dissolve in about 1 minute. Even if you take 3 capsules at a time, the chewing time is about 2 minutes. It is difficult to make a chew for the length of chewing time. Call it enough. Further, the edible rubber which is a rubber base for wheat gluten is kneaded into a wet mass in a water-containing state, and there is a problem that the chewability is likely to deteriorate over time. Further, in the chewing gum in which the functional component is mixed, since the rubber matrix is a synthetic polymer and has no edible property, it is discarded after being chewed and has a problem of polluting the environment, and the functional component is also discarded together with the rubber matrix, and the production is impossible. The problem of fully utilizing functional ingredients. On the other hand, the functional gummy of the gliadin fraction which is kneaded with wheat gluten under water condition is easy to mold because it has a moisture content of about 25 wt.%, and must be coated with sugar and coated. Anti-mildew treatment such as film. This type of functional chewable material with high water content has a problem of limited functional properties due to the inability to mix lactic acid bacteria and enzymes that are susceptible to moisture. Furthermore, after the functional chew is stored for 4 months under TC, the chewing elasticity is significantly lower. Further, after 15 minutes of chewing, it is no longer wet. 5-200816932 (3) Functionality of the chew Chews, for people, such as the elderly, children and women, have difficulty in taking insoluble functional ingredients due to difficulty in swallowing. When making functional chews from wet blocks, due to kneading and delay It requires a lot of pressure, and it is impossible to use a general mixer and a calender. It requires a special manufacturing equipment and has a problem of greatly increasing the manufacturing cost. The present invention is in view of the above-mentioned situation, that is, the chewing time of the soft candy is increased and is different. While chewing for a long period of time, and providing a functional ingredient that is beneficial for maintaining or restoring the physiological effects of health and the therapeutic effect of the disease, and providing properties that are beneficial for maintaining or restoring the physiological effects of the disease and the therapeutic effect of the disease, the ingestible For the purpose of solving the above problems, the inventors of the present invention have discovered the purpose of the functional chews, the manufacturing method thereof and the method of use thereof. Adding or mixing a variety of functional ingredients such as prolamin, wheat gluten or/and polyphenols, by laminating or granulating, can be moderately elastic after saliva-containing chewing The invention is completed by the incorporation of the functional ingredient of the edible property, and the functional chewable of the preparation which can be taken without the need for moisture, and the present invention is completed. The first item of the scope relates to a functional beta chew which is tableted or granulated with prolamin, wheat gluten and functional materials, and produces elasticity after saliva-containing chewing. The stretchable, more edible soft candy further prolongs its chewing time and constitutes a functional chew of the second aspect of the patent application scope of the invention, such as the patent scope of the first item -6-200816932 (4), wherein The ratio of prolamin to wheat gluten is composed of a weight ratio of 8:2 to 2 ··8. The third aspect of the present invention relates to a functional chew which is a prolamin. Class, more Classes and functional materials are raw materials that will be tableted or granulated, and will produce elasticity and stretch after saliva-containing chewing. It is more prolonged in chewing time than the edible soft candy, and is enhanced by polyphenols. It is composed of its elasticity and extensibility. φ The fourth item of the scope of the invention relates to a functional chew which is based on gliadin, wheat gluten, polyphenols and functional materials. Ingots or granules, which produce elasticity and stretchability after saliva-containing chewing, which is longer than the edible soft candy to prolong the chewing time, and is composed of polyphenols to enhance its elasticity and stretchability. The fifth item of the patent scope is a functional chew according to item 4 of the patent application scope, wherein the ratio of the prolamin to the wheat gluten is 9: 9: 0 · 1 to 2: 8 by weight ratio. . • The sixth aspect of the present invention is a functional chew according to claim 3 or 4, wherein the chew is mixed with 1 to 20% of the amount of the prolamin and the wheat bond. It is composed of many scorpions. Item 7 of the scope of the patent application of the present invention is a functional chew according to Patent Application No. 1, 3 ' ' or 4, wherein the gliadin is derived from wheat gliadin, corn zein, barley At least one of the selected barley proteins is composed. Item 8 of the scope of the patent application of the present invention is a functional chew as claimed in claim 1, 3 or 4, wherein the functional material is self-contained tea 200816932 (5) leaf catechin, gallop tea Ordinary gallic acid, buckwheat anthocyanins, polyphenols of French coastal pine bark extract, sesame xylan, reduced astaxanthin from Haematococcus 'γ-aminobutyric acid, step-down win Peptides, xylitol, frankincense extract, propolis, galacto, medicinal herbs extracts of medicinal herbs and wormwood " mushroom extracts, mushrooms, mulberry and monkey mushrooms, fucoids Sugar, - Heat treated lactic acid bacteria powder, lactoferrin, isoflavones, Ginkgo biloba extract, small vinca extract, phospholipid lysine, peanut oleic acid, φ 鱼类 from fish and DHA highly unsaturated fatty acids , chili powder, ketene, capsaicin ester, coenzyme Q-10, lipoic acid, carnitine hydrochloride, root orange extract, five-layer dragon extract, martial arts leaf extract, green bean extract, mulberry leaf Extracts, vitamins, yellow-green vegetable extracts, royal jelly, calcium Compounds • Magnesium compounds · Yeast zinc, minerals of iron, nourishing strong extracts of medicinal herbs, ceramide, hyaluronic acid, cysteine, carnitine, camphor extract, copper chlorophyll sodium, iron chlorophyll sodium At least one or more of lactic acid bacteria, inulin, fructooligosaccharide, galactooligosaccharide, xylooligosaccharide, nicotine, caffeine, and theanine are used. Item 9 of the scope of the present application is a functional chew as claimed in claim 1, 3 or 4, wherein the functional material is derived from apple anthocyanin, fruit extract, and blueberry extract. Polyterpenoids, cyanine glycoside from black beans, curcumin, tetrahydrocurcumin, sugarcane, octacosanol, collagen, phytic acid, aspirin, acetaminolate, dl-ma Acid chlorpheniramine, dihydrocodeine phosphate, dl-methylephedrine hydrochloride, ticlopidine citrate, chlorinated lysozyme, Meiyuanzhi extract, caffeine, allyl isopropyl At least one of acetonitrile, cetylpyridinium chloride, chlorhexidine hydrochloride, methyl-8-200816932 (6) potassium phenolsulfonate, bark of cherry, licorice, 1-menthol, sodium sulfonate The above composition. The tenth item of the present invention is a functional chew as claimed in claim 3 or 4, wherein the polyphenols are derived from catechins, " gallocatechin gallic acid It is composed of at least one selected from the group consisting of lipid, anthocyanin, anthocyanin, flavonol, diisoflavone, sesamin, quercetin, curcumin and persimmon tannin. φ. The eleventh item of the scope of the present application is a functional chew as disclosed in claim 1, 3 or 4, which is composed by mixing 1 to 40% of a protein decomposing enzyme. Item 12 of the scope of the present application is a functional chew as claimed in claim 1 wherein the proteolytic enzyme is selected from the group consisting of filamentous fungi, bacteria, basidiomycetes, radiobacteria and plant sources. The protein is composed of enzymes. The thirteenth item of the scope of the present application is a functional chew as disclosed in claim 1, item 1, Φ 3 or 4, which is composed by mixing 5 to 40% of a disintegrating agent. Item 14 of the scope of the present application is a functional chew according to claim 13 of the patent application, wherein the disintegrating agent is a protein selected from the group consisting of gelatin, casein sodium, casein calcium and collagen. Or carrageenan, Sanxian gum, gellan gum, tragacanth, agar, sodium carboxymethylcellulose, calcium hydroxymethylcellulose, polysaccharides of sodium alginate, polyethylene polyketene, Composition of fatty acid glycerides. Therefore, according to the first claim of the present invention, the gliadin--9-200816932 (7), wheat gluten and functional materials are used as raw materials for tableting or granulating, which is produced by saliva when chewed. Elasticity and extensibility, which can be longer and more chewy than various edible gums. In addition, since the gliadin, wheat gluten, and functional materials which are raw materials are edible, it is possible to take in a functional material containing a functional component without relying on the water solubility of the functional material. While maintaining and improving health or returning to health, it can also prevent aggravation after chewing, and can inhibit environmental pollution. Further, when the functional chew is swallowed, it can be completely digested by the digestive tract, and the functional material can be surely absorbed, and it is desired to maintain and improve health or restore health, and to treat the disease. Further, since the functional chew is edible, it is suitable for use in a preparation which does not require moisture. The wheat gluten used in the present invention is called powdery wheat protein of active gluten or vitamin gluten, and about 80% of the whole is composed of glutenin having a molecular weight of about 200,000 to several million, and the molecular weight is about It is composed of 30,000 to 80,000 wheat gel eggs Φ white. According to the third item of the patent application of the present invention, the prolamine, polyphenols and functional materials are used as raw materials for tableting or granulating, and when chewed, the elasticity and extensibility are generated after the saliva is contained. Due to the increased elasticity and extensibility of polyphenols, the more edible jelly has a longer chewing time of various lengths of time. In addition, since the prolamines, polyphenols, and functional materials used as raw materials are edible, it is desirable to maintain a functional material containing a functional component without depending on the water solubility of the functional material. While promoting health or returning to health, it can also prevent aggravation after chewing, such as chewing gum, and can inhibit environmental pollution. Further, when the functional chew is swallowed, it can be completely absorbed by the digestive tract, and the functional material can be surely absorbed, and it is desired to maintain and improve health or restore health, and to treat the disease. Further, since the functional chew has a food usability, that is, it can be used as a preparation which can be taken without water. According to the fourth aspect of the invention, the lozenge, wheat gluten, polyphenols and functional materials are used as raw materials for tableting or granulating φ, which generates elasticity and stretching after saliva-containing chewing. Sex, and because of the elasticity and extensibility of polyphenols, the edible gummy has a longer chewing time of various lengths of time. In addition, since the prolamines, polyphenols, and functional materials used as raw materials are edible, it is desirable to maintain a functional material containing a functional component without depending on the water solubility of the functional material. It can also prevent the abandonment of chewing gum and prevent environmental pollution when it improves health or restores health. Further, when swallowing a functional chew and swallowing it, it is possible to completely absorb the functional material by completely digesting the digestive tract, and it is desired to maintain and improve health or restore health, and to treat the disease. Further, since the functional chew is edible, it is suitable as a preparation which can be taken without water. According to the first, third and fourth aspects of the application of the present invention, when the functional chewable of the tableting or granulation is obtained, the raw material powder may be directly subjected to ingoting, or the raw material powder may be subjected to dry granulation. Further, the tableting is carried out, or the raw material powder is granulated by a wet granulation method such as a fluidized layer granulation drying method, and the drying is performed after the drying is equal to the steps commonly used in the manufacture of pharmaceuticals and health foods. Lozenge or granulation can be obtained to obtain a functional chew with a small amount of water-11 - 200816932 (9). Therefore, it is different from the functional chew which forms a high moisture content from the wet block, and the functional chew of the present invention having less moisture content does not need to be treated by the sugar coating and the film coating, and does not need to be kneaded. Special equipment such as calendering is manufactured by granulation, dryness, and ingots, which are highly versatile, and can significantly reduce manufacturing costs. The functional chews having a small moisture content of the present invention can be produced into tablets and granules using φ equipment such as a granulator, a dryer, and a tablet machine which are widely used in the pharmaceutical industry and the health food industry. When a functional chew having a small moisture content is produced, in the dry trial granulation method, the granules are produced by granulating the mixed powder by a dry granulator without adding water, and the granules are further produced in the preparation of the granules. Ingots. In the wet granulation method, the flow layer granulation drying method is carried out by spraying an aqueous solution with a gelatinized starch or the like on a raw material powder, and then drying the granules, and then granulating the granules in the preparation of the granules. In addition, since the gelatin protein becomes sticky when it contains water, it is difficult to clean the manufacturing equipment by the wet granulation method, and therefore φ is used as a dry granulation method which does not require the use of water as a binding liquid. The granulation method of the functional chew of the invention is particularly preferred. Conversely, when a functional chew having a high moisture content composed of a wet mass is produced, when 15 to 25 % of water is added to the raw material powder such as gliadin and kneaded, the wet mass becomes extremely ' In order to be sticky, it causes a burden on kneading, and it requires a large-sized kneader which is used when manufacturing chewing gum. Further, in order to stretch these wet pieces into a film and then cut them, it is necessary to use 2~ as in the manufacture of chewing gum. Special equipment such as calendering drum and cutting drum in three stages. In addition, the functional chews with high moisture content composed of wet masses are dried by hot air, and then the pellets obtained after crushing are carried out in -12-200816932 (10). When the tablet is produced by tableting, the wet block has high viscosity and needs to be dried for a long period of time. At the same time, since the obtained particles are too hard, it is difficult to form the tablet, and it is difficult to efficiently produce the tablet. Of course, the manufacturing cost is greatly increased. When the functional chew which is composed of a wet mass and has a high moisture content is freeze-dried, it is necessary to dry for 2 days or more, and 100,000 will be described. A small wet cake having a plate shape of about 10 mm is stored in a freeze dryer, and requires an extremely complicated operation, and the manufacturing cost is significantly increased as compared with the manufacturing method of the present invention which can ensure a daily output of φ of 1 million spindles or more. The present application can be mixed with lactic acid bacteria and enzymes which are susceptible to moisture due to tableting or granulation under conditions of low water activity, and solid functional ingredients which are insoluble in water, such as inorganic compound compounds such as mixed dolomite. When the proportion of the substrate of the prolamin/wheat gluten and the polyphenols is adjusted to a degree of chewing time of several minutes to 10 minutes, or by finely adjusting the weight of the chews per ingot 3 00~ 400mg, because it becomes easy to swallow, can surely and fully ingest the functional ingredients contained in the chew. As in the second claim of the present invention, in the first item of the patent application, the prolamin The ratio to wheat gluten is increased by 8:2~2:8, increasing the chewing time and increasing the number of chewings. ^ At the same time, by its edible nature, it does not discard functional materials and can be fully taken. It can be expected to maintain and improve health or restore health. It can be absorbed by completely digesting functional chews, and it is not only desirable to maintain and improve health or return to health, but also to treat diseases more appropriately. When the ratio of lysin to wheat gluten is 8:2, the ratio of wheat gluten is less than the ratio of 13-200816932 (11), which is weak due to weakening of elasticity and shortening of chewing time. When the ratio of gliadin to wheat gluten is 2:8, when the ratio of wheat gluten is more than this ratio, the stretchability becomes extremely small, and the chewing gum-like texture cannot be sufficiently changed while the formability is changed. Poor and the hardness of the tablet is low, which is not easy to use. In order to ensure the chewing taste of the functional chew of the present invention, the minimum mixing amount of the mixed substrate of the prolamin and the wheat gluten is preferably about 40% by weight. φ is the fifth item of the patent application scope of the present invention. In the fourth item of the patent application scope, when the ratio of the prolamin to the wheat gluten is 9.9 : 0.1 to 2 : 8 by weight, the growth is suitable for chewing. Time and increase the number of chews, while at the same time, by its edible nature, it does not discard functional materials and can be fully ingested, and it can be expected to maintain and improve health or restore health. It can be reliably absorbed by completely digesting functional chews, and it is not only desirable to maintain and improve health or restore health, but also to treat diseases more appropriately. When the ratio of the prolamin to the wheat gluten is 2:8, when the ratio of the gluten of the wheat gluten is larger than this, the stretchability is extremely small, and the chewing gum-like texture cannot be sufficiently formed. The properties are deteriorated and the hardness of the tablet is lowered, which is not easy to use. In order to ensure the chewing taste of the functional chew of the present invention, the minimum mixing amount of the mixed substrate of the prolamin and the wheat gluten is preferably about '30% by weight. As in the sixth aspect of the patent application of the present invention, in the third and fourth aspects of the patent application, when the polyphenols are mixed with 1 to 20% of the total amount of the prolamin and the wheat gluten, the chewing is fully increased. Time and increase the number of chewings, and because of its edible nature, it will not abandon functional materials and can fully ingest -14-200816932 (12), and can expect to maintain and improve health or restore health. Capable chewable material can be absorbed reliably, not only expecting vitamins to restore health, but also more suitable for treatment of diseases less than 1%, due to weakening of elasticity and shortening of chewing time; when the proportion of polyphenols is greater than 20% Will increase bitterness, • Poor. As in the seventh aspect of the invention, in the items φ 1, 3, and 4, the gliadin is selected from the wheat zein of wheat and the barley protein of barley, and the growth time is suitable for chewing time and increasing chewing. The number of times, sex, does not abandon functional materials and can be fully ingested, improve health or restore health. By fully digesting the function of on-site absorption, it is not only desirable to maintain and improve health or to treat diseases in a timely manner. Among the prolamins, the protein is also preferred, but the wheat gliadin is the most important, and the wheat gliadin is the best because the corn zein is larger in the ingot.

如同本發明申請專利範圍第8項,於 1、3、4項中功能性材料若自包含茶葉兒 ^ ~ 茶素沒食子酸脂、葡萄籽花青素原、法國 物之多酚類、芝麻木聚糖類、來自紅球藻 γ-氨基丁酸、降壓胜肽、木糖醇、乳香萃 蘿聚糖、肉宣蔻及艾草之藥材萃取物類、 頭蘇之薛類萃取物類、岩藻依聚糖、經力D 藉由完全消化功 持及增進健康或 。多酚類之比例 而不佳。反之, 且使成本變高而 申請專利範圍第 膠蛋白、玉米的 少一種而組成時 同時藉由其可食 而可期望維持及 性咀嚼物而可確 復健康,更可更 裸麥的麥膠蛋白 低價且易於取得 大麥蛋白爲佳, 申請專利範圍第 茶素、沒食子兒 海岸松樹皮萃取 之還原蝦紅素、 取物、蜂膠、海 蘑菇、桑黃及猴 I熱處理之乳酸菌 -15- 200816932 (13) . 菌體粉末、乳鐵蛋白、異黃酮、銀杏葉萃取物、小長春花 萃取物、磷脂醯絲胺酸、花生油酸、來自魚類的EPA及 DHA高度不飽和脂肪酸、辣椒粉末、烯酮素、辣椒素酯、 輔酶Q-10、硫辛酸、肉鹼鹽酸鹽、柑橘萃取物、五層龍 •萃取物、武靴葉萃取物、四季豆萃取物、桑葉萃取物、維 - 他命類、黃綠色蔬菜萃取物類、蜂王漿、鈣化合物•鎂化 合物·酵母鋅、鐵劑之礦物質類、滋養強壯用藥材萃取物 φ 類、腦醯胺、玻尿酸、半胱胺酸、胱胺酸、香覃萃取物、 銅葉綠素鈉、鐵葉綠素鈉、乳酸菌類、菊糖、果寡糖、半 乳糖寡糖、木寡糖、尼古丁、咖啡因、茶胺酸中選用至少 一種以上時,藉由選擇功能性材料,可活用爲感冒、口腔 內疾病及生活習慣病等特定疾病之治療用藥及預防食品, 或用作以特定年齡層及性別的人爲對象之功能性食品,亦 即利用爲適合想要節食及關心美白•美膚女性的食品,進 而利用爲適合希望抑制骨頭、免疫力及記憶力衰退高齡者 φ 的食品,或利用爲適合想要預防齲齒,強化齒幹的兒童及 青少年的食品。因此,藉由食用因應希望預防或治療之疾 病’及不同之年齡層、性別而混合之本發明的具功能性咀 嚼物來維持健康,更期望增進或回復健康,或進行疾病之 ‘ β 治療。 如同本發明申請專利範圍第9項,於申請專利範圍第 1、3、4項中功能性材料,若自蘋果花青素原、果露萃取 物、藍莓萃取物之多酚類、來自黑豆的青色素配糖體、薑 黃素、四氫薑黃素、甘蔗原素、二十八烷醇、膠原蛋白、 -16- 200816932 (14) ' 植酸、阿斯匹靈、乙醯胺酚、cil-馬來酸氯菲安明、磷酸二 黌 氫可待因、dl-鹽酸甲基麻黃鹼、檸檬酸替培匹啶、氯化溶 菌酶、美遠志流浸膏、咖啡因、烯丙基異丙基乙醯脲、十 六烷基氯化砒啶、鹽酸氯己啶、甲酚磺酸鉀、山櫻樹皮、 < 甘草、1-薄荷醇、奠磺酸鈉中選用至少一種以上時,藉由 • 選擇功能性材料,可活用爲感冒、口腔內疾病及生活習慣 病等特定疾病之治療用藥及預防食品,或用作以特定年齡 φ 層及性別的人爲對象之功能性食品,亦即利用爲適合想要 節食及關心美白•美膚女性的食品,進而利用爲適合希望 抑制骨頭、免疫力及記憶力衰退高齡者的食品,或利用爲 適合想要預防齲齒,強化齒幹的兒童及青少年的食品。因 此,藉由食用因應希望預防或治療之疾病,及不同之年齡 層、性別而混合之本發明的具功能性咀嚼物來維持健康, 更期望增進或回復健康,或進行疾病之治療。 具體而言,功能性材料中,包含茶葉兒茶素、沒食子 • 兒茶素沒食子酸脂、葡萄籽花青素原、蘋果花青素原、法 國海岸松樹皮萃取物、果露萃取物、藍莓萃取物之多酚類 、芝麻木聚糖類、來自黑豆的青色素配糖體、薑黃素、四 氫薑黃素、來自紅球藻之還原蝦紅素、輔酶Q-10、硫辛 / 酸係做爲抗氧化劑,甘蔗原素係做爲降低膽固醇劑及抑制 血小板凝集劑,適合使用爲生活習慣病之預防及回復,機 能性胺基酸之γ-氨基丁酸、降壓胜肽可改善高血壓,而加 入木糖醇、乳香萃取物、蜂膠、海蘿聚糖,肉宣蔻及艾草 之藥材萃取物類、植酸係口腔內疾病預防之有效成分。另 -17- 200816932 (15) , 外乳香萃取物係除去與胃癌及胃炎之症狀有關之憂門桿菌 的有效成分。蘑菇、桑黃及猴頭菇之菇類萃取物類、岩藻 依聚糖、經加熱處理之乳酸菌菌體粉末、乳鐵蛋白係提高 免疫力之成分,異黃酮、銀杏葉萃取物、小長春花萃取物 | 、磷脂醯絲胺酸、花生油酸、來自魚類的EPA及DHA高 ^ 度不飽和脂肪酸係癡呆及更年期症狀之有效成分,辣椒粉 末、烯酮素、辣椒素酯、輔酶Q-10、肉鹼鹽酸鹽、柑橘 φ 萃取物、五層龍萃取物、武靴葉萃取物、四季豆萃取物、 兒茶素、桑葉萃取物、二十八烷醇係抗肥胖物質之有效成 分,維他命類、黃綠色蔬菜萃取物類、蜂王漿、鈣化合物 •鎂化合物·酵母鋅、鐵劑之礦物質類、滋養強壯用藥材 萃取物類係常用於滋養強壯成分者,腦醯胺類、膠原蛋白 、玻尿酸、半胱胺酸、胱胺酸係美白•美膚之有效成分。 香覃萃取物、銅葉綠素鈉、鐵葉綠素鈉、兒茶素、蘋果多 酚等係常用做爲消臭之成分,乳酸菌類、菊糖、果寡糖、 Φ 半乳糖寡糖、木寡糖係有效之整腸成分。尼古丁係做爲戒 煙輔助劑之有效成分,咖啡因、茶胺酸係防止瞌睡及舒緩 用之有效成分。阿斯匹靈、乙醯胺酚、dl-馬來酸氯菲安明 、磷酸二氫可待因、dl -鹽酸甲基麻黃鹼、檸檬酸替培匹啶 * 、氯化溶菌酶、美遠志流浸膏、咖啡因、烯丙基異丙基乙 醯脲、十六院基氯化5比陡、鹽酸氯己Π定、甲酹磺酸鉀、山 櫻樹皮、甘草、1 -薄荷醇、葜磺酸鈉係感冒之各種症狀、 鎭咳去痰、解熱鎭痛及口腔咽喉症之適用成分。 對其他之功能性材料並無特別限制,可舉出使用適用 -18- 200816932 (16) 於糖尿病、高血壓、高血脂血症等生活習慣病之抗氧化劑 及胺基酸類’適用於牙周病等口腔疾病之成分,提高免疫 力成分,適用於癡呆及更年期症狀之成分,適用於病毒感 染成分,抗肥胖物質,滋養強壯成分,美白•美膚成分等 ' ,亦可使用香草類、催眠誘導成分之甘氨酸等。 、 如同本發明申請專利範圍第1 〇項,於申請專利範圍 第3或4項中,多酚類係自兒茶素類、沒食子兒茶素沒食 φ 子酸脂、花青素原、花青素、黃酮醇、異黃酮、芝麻素、 槲黃素、薑黃素、柿單寧中選用至少一種而組成時,增長 適合之咀嚼時間及增加咀嚼次數,同時藉由其可食性,不 會拋棄功能性材料且可充分攝取,而可期望維持及增進健 康或回復健康。藉由完全消化功能性咀嚼物而可確實地吸 收’不僅期望維持及增進健康或回復健康,同時更可更適 切地進行疾病之治療。 如同本發明申請專利範圍第1 1項,於申請專利範圍 Φ 第1、3或4中,混合1〜40%之蛋白質分解酵素劑時,藉 由蛋白質分解酵素劑使彈性及集合性變小而易於分離,因 調整咀嚼時間變短而容易吞食,不會拋棄功能性材料且可 充分攝取,而可期望維持及增進健康或回復健康。更可更 / 適切地進行疾病之治療。 如同本發明申請專利範圍第1 2項,於申請專利範圍 第1 1項中,蛋白質分解酵素劑係由選自絲狀真菌、細菌 、擔子菌、放射菌及植物來源之蛋白質分解酵素時,使彈 性及集合性變小而易於分離,使其更加容易吞食。 -19- 200816932 (17) 如同本發明申請專利範圍第1 3項,於申請專利範圍 第1、3或4項中,混合5〜40 %之助崩解劑時,藉由助崩 解劑使彈性及集合性變小而易於分離,因調整咀嚼時間變 短而容易吞食,不會拋棄功能性材料且可充分攝取,而可 " 期望維持及增進健康或回復健康。藉由完全消化功能性咀 - 嚼物而可確實地吸收,不僅期望維持及增進健康或回復健 康,同時更可更適切地進行疾病之治療。 φ 如同本發明申請專利範圍第14項,於申請專利範圍 第13項中,助崩解劑係選自明膠、酪蛋白鈉、酪蛋白鈣 及膠原蛋白之蛋白質,或角叉菜膠、三仙膠、結冷膠、黃 耆膠、洋菜、羥甲基纖維素鈉、羥甲基纖維素鈣、海藻酸 鈉之多醣類,聚乙烯聚咯烷酮、脂肪酸甘油酯時,使彈性 及集合性變小而易於分離,使其更加容易呑食。 接著針對本發明之具功能性之咀嚼物之製造方法加以 說明。 • 本發明申請專利範圍第1 5項係關於一種具功能性之 咀嚼物之製造方法,其係以醇溶蛋白類、小麥麩質及功能 性材料爲原料將其錠劑化或顆粒化而成。 , 負 本發明申請專利範圍第1 6項係於申請專利範圍第1 5 n 項中,醇溶蛋白類與小麥麩質之比例係重量比爲8 : 2〜2 : 8所構成。 本發明申請專利範圍第1 7項係關於一種具功能性之 咀嚼物之製造方法,其係將醇溶蛋白類、多酚類及功能性 材料錠劑化或顆粒化而成。 -20 - 200816932 (18) 本發明申請專利範圍第1 8項係關於一種具功能性之 咀嚼物之製造方法,其係將醇溶蛋白類、小麥麩質、多酚 類及功能性材料錠劑化或顆粒化而成。 本發明申請專利範圍第1 9項係申請專利範圍第1 8項 中,醇溶蛋白類與小麥麩質之比例係重量比爲9 · 9 : 0.1〜2 :8所構成。 本發明申請專利範圍第20項係於申請專利範圍第1 7 φ 或1 8項中’由相對於醇溶蛋白類與小麥麩質合計量混合 入1〜20%之多酚類所組成。 本發明申請專利範圍第21項係於申請專利範圍第i 5 、17或18項中,混合i〜4〇%之蛋白質分解酵素劑。 本發明申請專利範圍第22項係申請專利範圍第1 5、 17或18項中,混合5〜40%之助崩解劑。 根據申請專利範圍第1 5、1 6項,製造錠劑的具功能 性之阻嚼物時’首先需準備混合比例爲8 : 2〜2 : 8之由醇 溶虫白通與小麥魅質所構成之基材原料粉,可加入功能性 材料、甜味料、香料、潤滑劑等於基材原料粉中再進行打 锭’或是將基材原料粉、功能性材料、甜味料、香料、潤 滑劑等所構成之混合粉末進行乾式造粒後再進行打錠,或 , 是將基材原料粉、功能性材料、甜味料、香料、潤滑劑等 所構成之混合粉末,以殿粉糊做爲結合劑,藉由流動層造 k乾燥法寺濕式造粒法而進行造粒,再將乾燥後所得顆粒 加入香料、潤滑劑等後進行打錠,而製造鏡劑的具功能性 之咀嚼物。反之,製造顆粒的具功能性之咀嚼物時,首先 -21 - 200816932 (19) 需準備混合比例爲8 : 2〜2 : 8之由醇溶蛋白類與小麥鍵質 所構成之基材原料粉,可加入功能性材料、甜味料、香料 、潤滑劑等於基材原料粉中進行乾式造粒,或是將基材原 料粉、功能性材料、甜味料等所構成之混合粉末,以殿粉 "糊做爲結合劑,藉由流動層造粒乾燥法等濕式造粒法而進 . 行造粒,再將乾燥後所得顆粒加入香料等而製造顆粒的具 功能性之咀嚼物。錠劑或顆粒形式的具功能性之咀嚼物之 φ 製造步驟,可使用泛用於醫藥品及健康食品之製造步驟, 亦即可使用乾試造粒機、流動層造粒乾燥機、轉動流動造 粒機、打錠機等常用製劑機械。 因此,根據申請專利範圍第15、16項,由醇溶蛋白 類與小麥麩質所構成之基材原料粉中添加功能性材料等, 再施以造粒、乾燥、打錠等一般性的製劑手法,以非常簡 便的操作即可製造水分含量低之具功能性之咀嚼物。因此 與自濕塊物形成水分含量高之功能性咀嚼物相異,於水分 含量少的本發明之功能性咀嚼物,不需要藉由糖衣及薄膜 包覆之防霉處理,切不需混捏•壓延等特殊設備,因其係 藉由泛用性高之造粒•乾燥•打錠而製造,亦可大幅減低 製造成本。 ^ 本發明之水分含量少的功能性咀嚼物,可使用醫藥品 業界及健康食品業界所泛用之造粒機·乾燥機•打錠機等 設備而製造爲錠劑及顆粒。製造水分含量少的功能性咀嚼 物時,於乾試造粒法中,無須加水,將以混合之粉末藉由 乾試造粒機進行造粒而製造顆粒,於製造錠劑時再將該顆 -22 - 200816932 (20) 粒進行打錠。濕式造粒法中之流動層造粒乾燥法,於原料 粉末上以α化之澱粉等連接水溶液進行噴霧,再製造乾燥 顆粒,於製造錠劑時再將該顆粒進行打錠。另外,因麥膠 蛋白含水時會變爲黏稠而產生黏著性,於濕式造粒法不易 - 清潔製造設備,也因此以將無需使用水做爲結合液之乾式 . 造粒法,做爲本發明之功能性咀嚼物之造粒法爲特佳。相 反地,製造由濕塊物所構成的水分含量高之功能性咀嚼物 φ 時,加入15〜25%的水於麥膠蛋白等原料粉末再進行混捏 時,因爲濕塊物變得極爲黏稠,造成混捏時的負擔,而需 要如同製造口香糖時所使用之大型強力的捏和機。進而爲 將這些濕塊物拉伸爲薄膜再進行裁斷,需要如同製造口香 糖時所使用之2〜3段的壓延滾筒與裁斷滾筒等特殊設備。 另外,製造將由濕塊物所構成的水分含量高之功能性咀嚼 物進行熱風乾燥,再進行破碎後所得之顆粒進行打錠而製 造錠劑時,因濕塊物具高黏稠性而須進行長時間的乾燥, φ 同時,因所得顆粒過硬而難以而於打錠時成形性不佳,難 以有效率地製造錠劑,當然大幅提升製造成本。將由濕塊 物所構成的水分含量高之功能性咀嚼物進行冷凍乾燥時, 需要乾燥2天以上的長時間,且將述十萬個一片約10mm / 板狀的小濕塊物收納於冷凍乾燥機中,需要極爲繁雜之操 做,與可確保每日產量爲1〇〇萬錠以上之本發明的製造方 法相比,製造成本顯著增加。 本申請案因於水分活性低之條件下錠劑化或顆粒化, 而可混合易受水分影響的乳酸菌及酵素。不溶於水的固體 -23- 200816932 ' (21) 狀功能性成分,例如混合白雲石等無機化合物之配方時, 將醇溶蛋白/小麥麩質之基材比例及多酚類之混合量,調 整爲數分鐘到10分鐘的咀嚼時間程度,或藉由細微地調 整咀嚼物重量每一錠300〜400 mg,因變爲易於吞囉,而可 : 確實且充分地攝取咀嚼物中所含之功能性成分。 - 根據申請專利範圍第1 7、2 0項,製造錠劑的具功能 性之咀嚼物時,需準備爲使相對於醇溶蛋白類混合i〜2〇 % φ 之多酚類,由醇溶蛋白類及多酚類所組成之基材原料粉, 該基材原料粉可加入功能性材料、甜味料、香料、潤滑劑 等,再進行打錠,或是將基材原料粉、功能性材料、甜味 料、香料、潤滑劑等所構成之混合粉末進行乾式造粒後再 進行打錠,或是將基材原料粉、功能性材料、甜味料、香 料、潤滑劑等所構成之混合粉末,以激粉糊做爲結合劑, 藉由流動層造粒乾燥法等濕式造粒法而進行造粒,再將乾 燥後所得顆粒加入香料、潤滑劑等後進行打錠,而製造錠 φ 劑的具功能性之咀嚼物。反之製造顆粒的具功能性之咀嚼 物時’同樣的需準備爲使相對於醇溶蛋白類混合i〜2 〇 %之 多酚類’由醇溶蛋白類及多酚類所組成之基材原料粉,可 加入功能性材料、甜味料、香料、潤滑劑等於基材原料粉 中進行乾式造粒,或是將基材原料粉、功能性材料、甜味 料等所構成之混合粉末,以澱粉糊做爲結合劑,藉由流動 層造粒乾燥法等濕式造粒法而進行造粒,再將乾燥後所得 顆粒加入香料等而製造顆粒的具功能性之咀嚼物。錠劑或 顆粒形式的具功能性之咀嚼物之製造步驟,可使用泛用於 -24- 200816932 (22) 醫藥品及健康食品之製造步驟 流動層造粒乾燥機、轉動流動 機械。 根據申請專利範圍第1 7、 酣類所構成之基材原料粉中添 粒、乾燥、打錠等一般性的製 即可製造水分含量低之具功能 物形成水分含量高之功能性咀 本發明之功能性咀嚼物,不需 霉處理,切不需混捏•壓延等 性高之造粒•乾燥•打錠而製 〇 本發明之水分含量少的功 業界及健康食品業界所泛用之 設備而製造爲錠劑及顆粒。製 物時,於乾試造粒法中,無須 乾試造粒機進行造粒而製造顆 粒進行打錠。濕式造粒法中之 粉末上以α化之澱粉等連接水 顆粒,於製造錠劑時再將該顆 蛋白含水時會變爲黏稠而產生 清潔製造設備,也因此以將無 造粒法,做爲本發明之功能性 反地,製造由濕塊物所構成的 ,亦即可使用乾試造粒機、 造粒機、打錠機等常用製劑 20項,由醇溶蛋白類與多 加功能性材料等,再施以造 劑手法,以非常簡便的操作 性之咀嚼物。因此與自濕塊 嚼物相異,於水分含量少的 要藉由糖衣及薄膜包覆之防 特殊設備,因其係藉由泛用 造,亦可大幅減低製造成本 能性咀嚼物,可使用醫藥品 造粒機•乾燥機•打錠機等 造水分含量少的功能性咀嚼 加水,將以混合之粉末藉由 粒,於製造錠劑時再將該顆 流動層造粒乾燥法,於原料 溶液進行噴霧,再製造乾燥 粒進行打錠。另外,因麥膠 黏著性,於濕式造粒法不易 需使用水做爲結合液之乾式 咀嚼物之造粒法爲特佳。相 水分含量高之功能性咀嚼物 -25- 200816932 (23) 時,加入15〜25%的水於麥膠蛋白等原料粉末再進行混捏 時,因爲濕塊物變得極爲黏稠,造成混捏時的負擔,而需 要如同製造口香糖時所使用之大型強力的捏和機。進而爲 將這些濕塊物拉伸爲薄膜再進行裁斷,需要如同製造口香 糖時所使用之2〜3段的壓延滾筒與裁斷滾筒等特殊設備。 另外,製造將由濕塊物所構成的水分含量高之功能性咀嚼 物進行熱風乾燥,再進行破碎後所得之顆粒進行打錠而製 造錠劑時,因濕塊物具高黏稠性而須進行長時間的乾燥, 同時,因所得顆粒過硬而難以而於打錠時成形性不佳,難 以有效率地製造錠劑,當然大幅提升製造成本。將由濕塊 物所構成的水分含量高之功能性咀嚼物進行冷凍乾燥時, 需要乾燥2天以上的長時間,且將述十萬個一片約l〇mm 板狀的小濕塊物收納於冷凍乾燥機中,需要極爲繁雜之操 做,與可確保每日產量爲100萬錠以上之本發明的製造方 法相比,製造成本顯著增加。 本申請案因於水分活性低之條件下錠劑化或顆粒化, 而可混合易受水分影響的乳酸菌及酵素。不溶於水的固體 狀功能性成分,例如混合白雲石等無機化合物之配方時, 將醇溶蛋白/小麥麩質之基材比例及多酚類之混合量,調 整爲數分鐘到1 〇分鐘的咀嚼時間程度,或藉由細微地調 整咀嚼物重量每一錠3 00〜400mg,因變爲易於吞嚥,而可 確實且充分地攝取咀嚼物中所含之功能性成分。 根據申請專利範圍第1 8、19、20項,製造錠劑的具 功能性之咀嚼物時,醇溶蛋白類與小麥麩質之比例係重量 -26- 200816932 (24) 比爲9.9 · ϋ」〜2 : 8,同時,爲使相對於醇溶蛋白與小麥 麩質類之合計量混合^20%之多酚類,需準備由醇溶蛋白 類、小麥變質及多酣類所組成之基材原料粉,於該基材原 料粉加入功能性材料、甜味料、香料、潤滑劑等,再進行 打錠,或是將基材原料粉、功能性材料、甜味料、香料、 潤滑劑等所構成之混合粉末進行乾式造粒後再進行打錠, 或是將基材原料粉、功能性材料、甜味料、香料、潤滑劑 • 等所構成之混合粉末,以澱粉糊做爲結合劑,藉由流動層 造粒乾燥法等濕式造粒法而進行造粒,再將乾燥後所得顆 粒加入香料、潤滑劑等後進行打錠,而製造錠劑的具功能 性之咀嚼物。反之製造顆粒的具功能性之咀嚼物時,醇溶 蛋白類與小麥鍵質之比例係重量比爲9 · 9 : 〇 . 1〜2 : 8,同 時,爲使相對於醇溶蛋白與小麥麩質類之合計量混合丨〜2〇 %之多酚類,需準備由醇溶蛋白類、小麥麩質及多酚類所 組成之基材原料粉,可加入功能性材料、甜味料、香料、 Φ 潤滑劑等於基材原料粉中進行乾式造粒,或是將基材原料 粉、功能性材料、甜味料等所構成之混合粉末,以殿粉糊 、 做爲結合劑,藉由流動層造粒乾燥法等濕式造粒法而進行 造粒’再將乾燥後所得顆粒加入香料等而製造顆粒的具功 能性之咀嚼物。錠劑或顆粒形式的具功能性之咀嚼物之製 造步驟’可使用泛用於醫藥品及健康食品之製造步驟,亦 即可使用乾試造粒機、流動層造粒乾燥機、轉動流動造粒 機、打錠機等常用製劑機械。 因此根據申請專利範圍第1 8、1 9、2 0項,由醇溶蛋 -27- 200816932 (25) 白類、小麥麩質與多酚類所構成之基材原料粉中添加功能 性材料等,再施以造粒、乾燥、打錠等一般性的製劑手法 ,以非常簡便的操作即可製造水分含量低之具功能性之咀 嚼物。因此與自濕塊物形成水分含量高之功能性咀嚼物相 異,於水分含量少的本發明之功能性咀嚼物,不需要藉由 糖衣及薄膜包覆之防霉處理,切不需混捏•壓延等特殊設 備’因其係藉由泛用性高之造粒•乾燥•打錠而製造,亦 可大幅減低製造成本。 本發明之水分含量少的功能性咀嚼物,可使用醫藥品 業界及健康食品業界所泛用之造粒機·乾燥機•打錠機等 設備而製造爲錠劑及顆粒。製造水分含量少的功能性咀嚼 物時,於乾試造粒法中,無須加水,將以混合之粉末藉由 乾試造粒機進行造粒而製造顆粒,於製造錠劑時再將該顆 粒進行打錠。濕式造粒法中之流動層造粒乾燥法,於原料 粉末上以α化之澱粉等連接水溶液進行噴霧,再製造乾燥 顆粒,於製造錠劑時再將該顆粒進行打錠。另外,因麥膠 蛋白含水時會變爲黏稠而產生黏著性,於濕式造粒法不易 清潔製造設備,也因此以將無需使用水做爲結合液之乾式 造粒法,做爲本發明之功能性咀嚼物之造粒法爲特佳。相 反地,製造由濕塊物所構成的水分含量高之功能性咀嚼物 時,加入15〜25%的水於麥膠蛋白等原料粉末再進行混捏 時,因爲濕塊物變得極爲黏稠,造成混捏時的負擔,而需 要如同製造口香糖時所使用之大型強力的捏和機。進而爲 將這些濕塊物拉伸爲薄膜再進行裁斷,需要如同製造口香 -28- 200816932 (26) 糖時所使用之2〜3段的壓延滾筒與裁斷滾筒等特殊設備。 另外,製造將由濕塊物所構成的水分含量高之功能性咀嚼 物進行熱風乾燥’再進行破碎後所得之顆粒進行打錠而製 造錠劑時’因濕塊物具高黏稠性而須進行長時間的乾燥, "同時,因所得顆粒過硬而難以而於打錠時成形性不佳,難 - 以有效率地製造錠劑,當然大幅提升製造成本。將由濕塊 物所構成的水分含量高之功能性咀嚼物進行冷凍乾燥時, φ 需要乾燥2天以上的長時間,且將述十萬個一片約10mm 板狀的小濕塊物收納於冷凍乾燥機中,需要極爲繁雜之操 做,與可確保每日產量爲100萬錠以上之本發明的製造方 法相比,製造成本顯著增加。 本申請案因於水分活性低之條件下錠劑化或顆粒化, 而可混合易受水分影響的乳酸菌及酵素。不溶於水的固體 狀功能性成分,例如混合白雲石等無機化合物之配方時, 將醇溶蛋白/小麥麩質之基材比例及多酚類之混合量,調 Φ 整爲數分鐘到1 〇分鐘的咀嚼時間程度,或藉由細微地調 整咀嚼物重量每一錠3 00〜400mg,因變爲易於吞嚥,而可 確實且充分地攝取咀嚼物中所含之功能性成分。 如本發明申請專利範圍第21項所示,於申請專利範 ’ 圍第15、17或18項中,混合1〜40%之蛋白質分解酵素劑 時,可調整咀嚼時間而製造具功能性咀嚼物。 如本發明申請專利範圍第2 2項所示,於申請專利範 圍第15、17或18項中,混合5〜40%之助崩解劑時,可調 整咀嚼時間而製造具功能性咀嚼物。 -29- 200816932 (27) 進而針對本發明之具功能性咀嚼物之使用方法加以說 明。 本發明之申請專利範圍第23項係關於一種具功能性 之咀嚼物之使用方法,其係咀嚼如·申請專利範圍第1〜8項 "或第1 〇項中任一項之具功能性之咀嚼物後,再追加咀嚼 - 如申請專利範圍第11項之具功能性之咀嚼物而組成。 本發明之申請專利範圍第24項係關於一種具功能性 φ 之咀嚼物之使用方法,其係咀嚼如申請專利範圍第9項之 具功能性之咀嚼物後,再追加咀嚼如申請專利範圍第1 1 項之具功能性之咀嚼物而組成。 本發明之申請專利範圍第25項係關於一種具功能性 之咀嚼物之使用方法,其係咀嚼如申請專利範圍第1〜8項 或第1 〇項中任一項之具功能性之咀嚼物,咀嚼時間爲1 〇 分鐘以上,再重新追加咀嚼咀嚼時間爲2分鐘以下之固狀 咀嚼物或具功能性之咀嚼物而組成。 φ 本發明之申請專利範圍第26項係關於一種具功能性 之咀嚼物之使用方法,其係咀嚼如申請專利範圍第9項之 具功能性之咀嚼物,咀嚼時間爲1 〇分鐘以上,再重新追 加咀嚼咀嚼時間爲2分鐘以下之固狀咀嚼物或具功能性之 ' 咀嚼物而組成。 本發明之申請專利範圍第27項係如申請專利範圍第 25或26項之具功能性之咀嚼物之使用方法,其中固狀咀 嚼物係醇溶蛋白類或醇溶蛋白類與小麥麩質比例爲重量比 9.9: 0.1 〜8.1: 1.9。 -30- 200816932 (28) 本發明之申請專利範圍第28項係關於一種具功能性 之咀嚼物之使用方法,其係咀嚼如申請專利範圍第1〜8項 或第1 〇項中任一項之具功能性之咀嚼物,咀嚼時間爲1 0 分鐘以上,再追加咀嚼有機酸之錠劑而組成。 -本發明之申請專利範圍第2 9項係關於一種具功能性 • 之咀嚼物之使用方法,其係咀嚼如申請專利範圍第9項之 具功能性之咀嚼物,咀嚼時間爲1 〇分鐘以上,再追加咀 φ 嚼有機酸之錠劑而組成。 本發明之申請專利範圍第3 0項係如申請專利範圍第 28或29項之具功能性之咀嚼物之使用方法,其中有機酸 係自檸檬酸、蘋果酸、酒石酸、琥珀酸、葡萄糖酸、乳酸 、醋酸中選用至少一種而組成。 本發明之申請專利範圍第3 1項係關於一種具功能性 之咀嚼物之使用方法,其係咀嚼如申請專利範圍第1〜8項 或第1 〇項中任一項之具功能性之咀嚼物,咀嚼時間爲1 〇 φ 分鐘以上,再重新追加咀嚼速崩解錠而組成。 本發明之申請專利範圍第3 2項係關於一種具功能性 之咀嚼物之使用方法,其係咀嚼如申請專利範圍第9項之 ^ 1 具功能性之咀嚼物,咀嚼時間爲1 0分鐘以上,再重新追 / 加咀嚼速崩解錠而組成。 本發明之申請專利範圍第3 3項係關於如申請專利範 圍第3 1或32項之具功能性之咀嚼物之使用方法,其中速 崩解錠係含有選自檸檬酸、蘋果酸、酒石酸、琥珀酸、葡 萄糖酸、乳酸、醋酸、抗壞血酸之有機酸,明膠、酪蛋白 -31 - 200816932 (29) 鈉、膠原蛋白之蛋白質,角叉菜膠、三仙膠、結冷膠、黃 耆膠、洋菜、羥甲基纖維素鈉、羥甲基纖維素鈣、海藻酸 鈉之多醣類,多麩醯胺酸、精胺酸、可可粉、乳酪粉中至 少一種而組成。 - 如本發明之申請專利範圍第23項所示,咀嚼如申請 • 專利範圍第1〜8項或第1 0項中任一項之具功能性之咀嚼 物後,再追加咀嚼如申請專利範圍第1 1項之具功能性之 φ 咀嚼物時,藉由申請專利範圍第11項之蛋白質分解酵素 劑使彈性及集合性變小而易於分離,因縮短咀嚼時間,可 依喜好而調整咀嚼時間,其結果使具功能性之咀嚼物變得 容易吞食,而可期望維持及增進健康或回復健康。更可更 適切地進行疾病之治療。 如本發明之申請專利範圍第24項所示,咀嚼如申請 專利範圍第9項之具功能性之咀嚼物後,再追加咀嚼如申 請專利範圍第11項之具功能性之咀嚼物時,藉由申請專 • 利範圍第11項之蛋白質分解酵素劑使彈性及集合性變小 而易於分離,因縮短咀嚼時間,可依喜好而調整咀嚼時間 ,其結果使具功能性之咀嚼物變得容易吞食,而可期望維 持及增進健康或回復健康。更可更適切地進行疾病之治療 礞 〇 如本發明之申請專利範圍第25項所示,咀嚼如申請 專利範圍第1〜8項或第1 〇項中任一項之具功能性之咀嚼 物,咀嚼時間爲1 〇分鐘以上,再重新追加咀嚼咀嚼時間 爲2分鐘以下之固狀咀嚼物或具功能性之咀嚼物時,藉由 -32- 200816932 (30) 對咀嚼時間爲2分鐘以下之固狀咀嚼物或功能性咀嚼物, 改變其與醇溶蛋白之比例或與多酚類之比例,藉由使彈性 及集合性變小而易於分離,因縮短咀嚼時間,可依喜好而 調整咀嚼時間,其結果使具功能性之咀嚼物其高咀嚼性與 "可吞食性變爲兩立,而可期望維持及增進健康或回復健康 ^ ,以及更適切地進行疾病之治療。更詳細地加以說明係例 如駕駛所使用的防止瞌睡用製品,最初的咀嚼時間係加入 Φ 尼古丁的錠劑所需合適的3 0分鐘,例如咀嚼3 0分鐘後覺 得厭煩時,再藉由追加咀嚼加入維他命的錠劑且其咀嚼時 間爲2分鐘以下,咀嚼物在2、3分鐘內彈性及集合性變 小,分散,即使是女性亦可容易呑食。 如本發明之申請專利範圍第26項所示,咀嚼如申請 專利範圍第9項之具功能性之咀嚼物,咀嚼時間爲1 0分 鐘以上,再重新追加咀嚼咀嚼時間爲2分鐘以下之固狀咀 嚼物或具功能性之咀嚼物時,藉由對咀嚼時間爲2分鐘以 Φ 下之固狀咀嚼物或功能性咀嚼物,改變其與醇溶蛋白之比 例或與多酚類之比例,藉由使彈性及集合性變小而易於分 ^ 離,因縮短咀嚼時間,可依喜好而調整咀嚼時間,其結果 使具功能性之咀嚼物其高咀嚼性與可吞食性變爲兩立,而 1 ' 可期望維持及增進健康或回復健康,以及更適切地進行疾 病之治療。更詳細地加以說明係例如駕駛所使用的防止瞌 睡用製品,最初的咀嚼時間係加入尼古丁的錠劑所需合適 的3 0分鐘,例如咀嚼3 0分鐘後覺得厭煩時,再藉由追加 咀嚼加入維他命的錠劑且其咀嚼時間爲2分鐘以下,咀嚼 -33- 200816932 (31) 物在2、3分鐘內彈性及集合性變小,分散,即使是女性 亦可容易吞食。 如本發明之申請專利範圍第27項所示,於申請專利 範圍第25或26項中,固狀咀嚼物係醇溶蛋白類或醇溶蛋 • 白類與小麥麩質比例爲重量比9.9 ·· 0.1〜8.1 : 1.9,時,藉 * 由簡單地改變與醇溶蛋白類之比例或與多酚類之比例。使 彈性及集合性變小而易於分散,咀嚼時間變短而使具功能 Φ 性之咀嚼物可容易吞食。 如本發明之申請專利範圍第28項所示,咀嚼如申請 專利範圍第1〜8項或第1 0項中任一項之具功能性之咀嚼 物’咀嚼時間爲1 〇分鐘以上,再追加咀嚼有機酸之錠劑 時,藉由含於錠劑中之有機酸成分,使彈性及集合性變小 而易於分散,縮短咀嚼時間,可依喜好而調整咀嚼時間, 其結果使具功能性之咀嚼物其高咀嚼性與可吞食性變爲兩 立’而可期望維持及增進健康或回復健康,以及更適切地 φ 進行疾病之治療。 如本發明之申請專利範圍第29項所示,咀嚼如申請 專利範圍第9項之具功能性之咀嚼物,咀嚼時間爲1 〇分 贅 鐘以上,再追加咀嚼有機酸之錠劑時,藉由含於錠劑中之 y 有機酸成分,使彈性及集合性變小而易於分散,縮短咀嚼 時間,可依喜好而調整咀嚼時間,其結果使具功能性之咀 嚼物其高咀嚼性與可吞食性變爲兩立.,而可期望維持及增 進健康或回復健康,以及更適切地進行疾病之治療。 如本發明之申請專利範圍第30項所示,申請專利範 -34- 200816932 (32) 圍第28或29項中,自有機酸係自檸檬酸 酸、琥珀酸、蔔萄糖酸、乳酸、醋酸中選 使彈性及集合性變小而易於分散,咀嚼時 能性之咀嚼物可容易吞食。 如本發明之申請專利範圍第3 1項所 專利範圍第1〜8項或第10項中任一項之 物,咀嚼時間爲1 0分鐘以上,再重新追 時,藉由速崩解錠中所含成分,使彈性及 於分散,縮短咀嚼時間,可依喜好而調整 果使具功能性之咀嚼物其高咀嚼性與可吞 而可期望維持及增進健康或回復健康,以 疾病之治療。更詳細地加以說明係例如駕 瞌睡用製品,最初的咀嚼時間係加入尼古 適的30分鐘,例如咀嚼30分鐘後覺得厭 加咀嚼加入維他命的錠劑且其咀嚼時間爲 嚼物在2、3分鐘內彈性及集合性變小, 性亦可容易吞食。 如本發明之申請專利範圍第32項所 專利範圍第9項之具功能性之咀嚼物,咱 鐘以上’再重新追加咀嚼速崩解錠時,藉 含成分’使彈性及集合性變小而易於分散 ’可依喜好而調整咀嚼時間,其結果使具 其高咀嚼性與可吞食性變爲兩立,而可期 康或回復健康,以及更適切地進行疾病之 、蘋果酸、酒石 用至少一種時, 間變短而使具功 示,咀嚼如申請 具功能性之咀嚼 加咀嚼速崩解錠 集合性變小而易 咀嚼時間,其結 食性變爲兩立, 及更適切地進行 駛所使用的防止 丁的錠劑所需合 煩時,再藉由追 2分鐘以下,阻 分散,即使是女 示,咀嚼如申請 .嚼時間爲1 0分 由速崩解錠中所 ,縮短咀嚼時間 功能性之咀嚼物 望維持及增進健 治療。更詳細地 -35- 200816932 (33) 加以說明係例如駕駿所使用的防止瞌睡用製品,最初的咀 嚼時間係加入尼古丁的錠劑所需合適的3 0分鐘,例如咀 嚼30分鐘後覺得厭煩時,再藉由追加咀嚼加入維他命的 錠劑且其咀嚼時間爲2分鐘以下,咀嚼物在、2、3分鐘內 彈性及集合性變小,分散,即使是女性亦可容易吞食。 如本發明之申請專利範圍第33項所示,申請專利範 圍第31或32項中,速崩解錠係自含有選自檸檬酸、蘋果 酸、酒石酸、琥珀酸、葡萄糖酸、乳酸、醋酸、抗壞血酸 之有機酸,明膠、酪蛋白鈉、膠原蛋白之蛋白質,角叉菜 膠、三仙膠、結冷膠、黃耆膠、洋菜、羥甲基纖維素鈉、 羥甲基纖維素鈣、海藻酸鈉之多醣類,多麩醯胺酸、精胺 酸、可可粉、乳酪粉中選用至少一種時,藉由使彈性及集 合性變小而易於分散,而調整咀嚼時間,而使具功能性之 咀嚼物可容易吞食。 咀嚼上述本發明之機能性咀嚼物時,較軟糖更長的咀 嚼時間及增加咀嚼次數的同時,因藉由使其具可食性而可 攝取機能材不會加以拋棄,而可適當地達成維持或回復健 康。同時可進而適當地進行疾病的治療。另外,因其具有 可食性,因此可獲得防止如因丟棄咀嚼後之口香糖而造成 環境污染問題的優異效果。 【實施方式】 實施例 本發明有如下所述之實施例。 -36- 200816932 (34) 實施例1 於〔實施例1〕中,混合醇溶蛋白類之麥膠蛋白(麥膠 蛋白分劃物)、小麥麩質之活性麩質(維生麩質)與功能性材 料之木糖醇及硬酯酸鈣(潤滑劑),以下述之範本配方調查 麥膠蛋白與麩質之比例,對於具機能性咀嚼物打錠時之成 形性、及其物性,亦即爲咀嚼時間(分鐘)、彈性及伸展性 具何種程度的影響。錠劑係使用靜態的壓縮機,製作大約 φ 爲錠徑15mm、單錠lOOOmg、錠劑硬度爲4〜5kg/cm2,對 如下所述之各評價項目進行評價。 (1) 成形性 測定錠劑硬度。 〇··錠劑硬度爲4〜5kg/cm2以上者。 △:錠劑硬度爲3kg/cm2上下者。 X :錠劑硬度爲2kg/cm2以下,即便製成錠亦容易破 損,難以用爲錠劑者。 (2) 物性 (a)咀嚼時間 τ 以1分鐘內咀嚼70〜80次的速度咀嚼1錠機能性咀嚼 ' 物,測定分散後至呑食的時間爲咀嚼時間(分鐘)。「1 5分 鐘以上」係咀嚼15分鐘後仍未分散而形成一整塊集合物 者0 (b)彈性 -37- 200816932 (35) 調查咀嚼時間評價之約2分鐘之前或咀嚼1 0分鐘後 之狀態。 ◎:彈性強且形成結實的橡膠塊狀者。 〇:稍柔軟且形成一整塊的橡膠塊狀者。 ~ :彈性弱且乾扁的塊狀物。 (c)伸展性 φ 調查咀嚼時間評價之約2分鐘之前或咀嚼1 0分鐘後 ,以牙齒咬咀嚼物,及以手指拉長後之狀態。 ◎:可拉長l〇cm以上者。 〇:可拉長5 c m左右者。 △:可拉長3cm左右者。 X :可拉長1 cm以下或無法拉長者。 -38 - 200816932 (36) 〔表1〕As in the eighth aspect of the patent application scope of the present invention, in the items 1, 3, and 4, if the functional material contains tea leaves, tea catechin gallate, grape seed anthocyanin, French polyphenols, Sesame xylan, extracts from Haematococcus γ-aminobutyric acid, antihypertensive peptide, xylitol, frankincense, medicinal herbs and wormwood extracts , fucoidan, and fertility D by fully digesting and improving health or. The proportion of polyphenols is not good. On the other hand, if the cost is increased and the patent application range is less than one type of gelatin and corn, it can be expected to maintain health and chews to be healthy, and more glutinous wheat. The protein is low-priced and easy to obtain barley protein. The patented range of tea, the reduced astaxanthin extracted from the bark of the pine tree bark, the extract, the propolis, the sea mushroom, the mulberry yellow and the heat-treated lactic acid bacteria of the monkey I-15 - 200816932 (13) . Bacterial powder, lactoferrin, isoflavones, Ginkgo biloba extract, small vinca extract, phospholipid lysine, peanut oleic acid, EPA and DHA highly unsaturated fatty acids from fish, chili powder , ketene ester, capsaicin ester, coenzyme Q-10, lipoic acid, carnitine hydrochloride, citrus extract, five-layer dragon extract, extract of sap leaves, green bean extract, mulberry leaf extract, Vitamins - genus, yellow-green vegetable extracts, royal jelly, calcium compounds, magnesium compounds, yeast zinc, iron minerals, nourishing strong medicinal extracts φ, ceramide, hyaluronic acid, cysteine , When at least one of aminic acid, citron extract, copper chlorophyll sodium, iron chlorophyll sodium, lactic acid bacteria, inulin, fructooligosaccharide, galactooligosaccharide, xylooligosaccharide, nicotine, caffeine, and theanine is used, at least one or more By selecting functional materials, it can be used as therapeutic and preventive foods for specific diseases such as colds, oral diseases and lifestyle-related diseases, or as functional foods for people of specific age and gender, that is, It is suitable for foods that are intended to be used for dieting and caring for women who are whitening and skincare, and for use in foods that are suitable for people who want to suppress bones, immunity, and memory decline, or for children and adolescents who want to prevent dental caries and strengthen their teeth. Food. Therefore, it is desirable to maintain health by promoting consumption of a functional chew of the present invention mixed with diseases and diseases of a different age group and gender, and it is more desirable to promote or restore health, or to perform 'β treatment of the disease. As in the ninth application of the present invention, in the scope of claims 1, 3, 4, the functional materials, if from the apple anthocyanin, fruit extract, blueberry extract polyphenols, from black beans Cyanine glycoside, curcumin, tetrahydrocurcumin, sugarcane, octacosanol, collagen, -16- 200816932 (14) ' Phytic acid, aspirin, acetaminophen, cil-maleic acid Chlorpheniramine, codeine hydroquinone phosphate, dl-methylephedrine hydrochloride, ticlopidine citrate, chlorinated lysozyme, Meiyuanzhi extract, caffeine, allyl isopropyl b Urea urea, cetylpyridinium chloride, chlorhexidine hydrochloride, potassium cresylate, mountain cherry bark, < When at least one of licorice, 1-menthol, and sodium sulfonate is used, it is possible to use therapeutic materials and preventive foods for specific diseases such as colds, oral diseases, and lifestyle-related diseases by selecting functional materials. Or use as a functional food for people of a certain age φ layer and gender, that is, for use in foods that are suitable for women who want to diet and care for whitening and beauty, and then use it as a suitable medium for suppressing bone, immunity, and memory loss. The food for the elderly, and the food for children and adolescents who want to prevent dental caries and strengthen the tooth dry. Therefore, it is desirable to maintain or restore health, or to treat a disease, by eating a functional chew of the present invention mixed with a disease which is desired to be prevented or treated, and a different age layer and gender. Specifically, the functional material includes tea catechin, gallnut • catechin gallate, grape seed anthocyanin, apple anthocyanin, French coastal pine bark extract, fruit dew Extract, polyphenols of blueberry extract, sesame xylan, cyanine glycoside from black beans, curcumin, tetrahydrocurcumin, reduced astaxanthin from Haematococcus, coenzyme Q-10, sulfur / Acid system as an antioxidant, sugar cane is used as a cholesterol lowering agent and a platelet agglutinating agent, suitable for use as a prevention and recovery of lifestyle-related diseases, functional amino acid γ-aminobutyric acid, antihypertensive peptide It can improve high blood pressure, and add xylitol, frankincense extract, propolis, keloid, medicinal extracts of medicinal herbs and wormwood, and phytic acid as an effective component for prevention of oral diseases. -17- 200816932 (15) The external frankincense extract removes the active constituents of Salmonella associated with the symptoms of gastric cancer and gastritis. Mushroom, mulberry and monkey mushroom extracts, fucoidan, heat-treated lactic acid bacteria powder, lactoferrin-based immune-enhancing ingredients, isoflavones, ginkgo biloba extract, small Changchun Flower extract |, phospholipid lysine, peanut oleic acid, EPA and DHA from fish, high-degree unsaturated fatty acid dementia and effective components of menopausal symptoms, pepper powder, ketene, capsaicin ester, coenzyme Q-10 , Carnitine hydrochloride, Citrus φ extract, Wulonglong extract, Wushou leaf extract, green bean extract, catechin, mulberry leaf extract, octacosanol anti-obesity active ingredient , vitamins, yellow-green vegetable extracts, royal jelly, calcium compounds, magnesium compounds, yeast zinc, iron minerals, nourishing and strong use of herbal extracts are often used to nourish strong ingredients, ceramide, collagen Protein, hyaluronic acid, cysteine, cystine, whitening, skin and active ingredients. Toona sinensis extract, copper chlorophyll sodium, iron chlorophyll sodium, catechin, apple polyphenols, etc. are commonly used as deodorant components, lactic acid bacteria, inulin, fructooligosaccharides, Φ galactose oligosaccharides, xylooligosaccharides An effective whole intestinal component. Nicotine is an effective ingredient in smoking cessation aids, and caffeine and theanine are effective ingredients for preventing drowsiness and soothing. Aspirin, acetaminophen, dl-malonate chlorpheniramine, dihydrocodeine phosphate, dl-methylephedrine hydrochloride, ticlopidine citrate*, chlorinated lysozyme, Meiyuanzhi immersion Cream, caffeine, allyl isopropyl acetonitrile, hexamethyl chlorinated 5 ratio steep, chlorhexidine hydrochloride, potassium sulfonate, mountain cherry bark, licorice, 1-menthol, sulphur Sodium sulphate is a suitable ingredient for various symptoms of the cold, cough and expectoration, antipyretic and painful, and oral and throat disease. Other functional materials are not particularly limited, and the use of antioxidants and amino acids for use in lifestyle-related diseases such as diabetes, hypertension, and hyperlipidemia are applicable to periodontal disease. It is a component of oral diseases, an immune-enhancing ingredient, and is suitable for components of dementia and menopausal symptoms. It is suitable for viral infections, anti-obesity substances, nourishing strong ingredients, whitening and skin-beautifying ingredients, etc. It can also be used with vanilla and hypnosis. The component of glycine and the like. As in the first aspect of the patent application scope of the present invention, in the third or fourth aspect of the patent application, the polyphenols are derived from catechins, gallocatechin, φ acid fat, anthocyanin When at least one of anthocyanins, flavonols, isoflavones, sesamin, quercetin, curcumin, and persimmon tannin is used, the chewing time is increased and the number of chewing is increased, and by its edible nature, Functional materials can be discarded and fully ingested, and it can be expected to maintain and improve health or restore health. By fully digesting functional chews, it is possible to reliably absorb not only the desire to maintain and improve health or restore health, but also to treat the disease more appropriately. As in the first aspect of the patent application scope of the present invention, in the first, third or fourth application range, when 1 to 40% of the proteolytic enzyme is mixed, the elasticity and aggregation are reduced by the protein decomposing enzyme. It is easy to separate, easy to swallow due to shortened chewing time, does not discard functional materials and can be fully ingested, and can be expected to maintain and improve health or restore health. It is even more appropriate / appropriate to treat the disease. As in the fifteenth aspect of the patent application of the present invention, in the first claim of claim 1, the proteolytic enzyme agent is selected from the group consisting of filamentous fungi, bacteria, basidiomycetes, radiobacteria, and plant-derived proteolytic enzymes. Elasticity and aggregability are small and easy to separate, making it easier to swallow. -19- 200816932 (17) As in the scope of claim 13 of the present invention, in the scope of claim 1, 3 or 4, when 5 to 40% of the disintegrant is mixed, the disintegrating agent is used. The elasticity and the aggregation are small and easy to separate. Because the chewing time is shortened, it is easy to swallow, and the functional material is not discarded and can be fully ingested, and it is desirable to maintain and improve health or restore health. It can be reliably absorbed by completely digesting the functional nozzle-chew, and it is not only desirable to maintain and improve health or restore health, but also to treat the disease more appropriately. φ is the 14th item of the patent application scope of the present invention. In the 13th item of the patent application, the disintegrating agent is selected from the group consisting of gelatin, casein sodium, casein calcium and collagen protein, or carrageenan and sanxian. Gel, gellan gum, tragacanth, agar, sodium carboxymethylcellulose, calcium carboxymethylcellulose, polysaccharides of sodium alginate, polyvinylpolyrrolidone, fatty acid glycerides, make elasticity and The collection becomes smaller and easier to separate, making it easier to forage. Next, a method of manufacturing a functional chew of the present invention will be described. • The fifteenth aspect of the present invention relates to a method for producing a functional chew which is obtained by injecting or granulating a gliadin, a wheat gluten and a functional material. . , Negative The scope of the patent application of the present invention is in the fifteenth item of the patent application, and the ratio of the prolamin to the wheat gluten is 8:2 to 2:8. The seventh aspect of the present invention relates to a method for producing a functional chew which is obtained by tableting or granulating prolamine, polyphenols and functional materials. -20 - 200816932 (18) The scope of the patent application of the present invention relates to a method for producing a functional chew, which comprises a gliadin, a wheat gluten, a polyphenol, and a functional material tablet. Made or granulated. In the ninth item of the patent application scope of the present invention, the weight ratio of the prolamine to the wheat gluten is 9 · 9 : 0. 1 to 2: 8 is composed. Item 20 of the scope of the patent application of the present invention is composed of a polyphenol of 1 to 20% in a total amount of the prolamin and the wheat gluten. Item 21 of the scope of application of the present invention is in the scope of the patent application range i5, 17 or 18, mixing i~4% of the proteolytic enzyme agent. Item 22 of the scope of the patent application of the present invention is in the scope of claim 15, 5 or 17 or 18, in which 5 to 40% of a disintegrating agent is mixed. According to Articles 15 and 16 of the scope of patent application, when manufacturing functional chewables of tablets, the first thing to prepare is to mix 8: 2~2: 8 by Alcohol-soluble Baitong and Wheat Charm. The raw material powder of the substrate may be added with a functional material, a sweetener, a fragrance, a lubricant equal to the base material powder and then subjected to tableting' or a base material powder, a functional material, a sweetener, a spice, The mixed powder composed of a lubricant or the like is subjected to dry granulation and then subjected to tableting, or a mixed powder composed of a base material powder, a functional material, a sweetener, a flavor, a lubricant, and the like, As a binder, the granulation is carried out by a wet layer granulation method, and the granules obtained after drying are added to a perfume, a lubricant, etc., and then ingot is prepared, and the functional agent of the mirror is chewed. Things. On the other hand, when manufacturing a functional chew of granules, first - 21 - 169, 932, 922 (19) prepare a base material powder composed of a prolamin and a wheat bond with a mixing ratio of 8:2 to 2:8. The functional material, the sweetener, the fragrance, the lubricant may be added to the base material powder for dry granulation, or the mixed powder of the base material powder, the functional material, the sweetener, etc. may be added to the temple. The powder " paste is used as a binder, and is carried out by a wet granulation method such as a fluidized layer granulation drying method.  The granules are granulated, and the granules obtained after drying are added to a scent or the like to produce a functional chew of granules. The manufacturing step of the functional chew in the form of tablets or granules can be used in the manufacturing steps of pharmaceuticals and health foods, and can also be used in dry trial granulators, flow layer granulation dryers, and rotating flows. Commonly used preparation machinery such as granulators and tableting machines. Therefore, according to the fifteenth and sixteenth items of the patent application, a functional material such as granulation, drying, and tableting is added to a base material powder composed of a prolamin and wheat gluten. By means of a very simple operation, it is possible to produce a functional chew with a low moisture content. Therefore, it is different from the functional chew which forms a high moisture content from the wet block, and the functional chew of the present invention having less moisture content does not need to be treated by the sugar coating and the film coating, and does not need to be kneaded. Special equipment such as calendering is manufactured by granulation, drying and tableting with high versatility, and can also greatly reduce manufacturing costs. The functional chews having a small moisture content of the present invention can be produced into tablets and granules using equipment such as a granulator, a dryer, and a tablet machine which are widely used in the pharmaceutical industry and the health food industry. When a functional chew having a small moisture content is produced, in the dry trial granulation method, granules are produced by granulating the mixed powder by a dry trial granulator without adding water, and the granule is produced when the granule is produced. -22 - 200816932 (20) Granules are used for tableting. In the wet granulation method, the fluidized layer granulation drying method is carried out by spraying an aqueous solution of a gelatinized starch or the like onto a raw material powder to produce dried granules, and the granules are further tableted in the production of a tablet. In addition, because gliadin becomes viscous when it contains water, it is sticky, and it is not easy to wet the granulation method - it is a dry type that does not require the use of water as a binding liquid.  The granulation method is particularly preferred as the granulation method of the functional chew of the present invention. Conversely, when a functional chew φ having a high moisture content composed of a wet mass is produced, when 15 to 25% of water is added to the raw material powder such as glutenin and kneaded, since the wet mass becomes extremely viscous, This creates a burden on the kneading and requires a large and powerful kneader as used in the manufacture of chewing gum. Further, in order to stretch these wet masses into a film and perform cutting, special equipment such as a calender roll and a cutting roll which are used in the production of chewing gum in the range of 2 to 3 stages are required. In addition, a functional chew which has a high moisture content, which is composed of a wet mass, is produced by hot air drying, and the granules obtained after the crushing are subjected to tableting to produce a tablet, which is required to be long because the wet block has high viscosity. Drying of time, φ At the same time, since the obtained particles are too hard to be formed, the formability is poor at the time of tableting, and it is difficult to efficiently manufacture the tablet, and the manufacturing cost is greatly increased. When the functional chew which is composed of a wet mass and has a high moisture content is freeze-dried, it is necessary to dry for a long time of 2 days or longer, and the 100,000 pieces of a small wet cake of about 10 mm / plate shape are stored in a freeze-dried state. In the machine, an extremely complicated operation is required, and the manufacturing cost is remarkably increased as compared with the manufacturing method of the present invention which can ensure a daily output of more than 10 million spindles. The present application can be mixed with lactic acid bacteria and enzymes which are susceptible to moisture due to tableting or granulation under conditions of low water activity. Insoluble in water -23- 200816932 ' (21) Functional ingredients, such as blends of inorganic compounds such as dolomite, adjust the ratio of the substrate of prolamin/wheat gluten and the amount of polyphenols. The degree of chewing time of several minutes to 10 minutes, or by finely adjusting the weight of the chew by 300 to 400 mg per ingot, as it becomes easy to swallow, it can: surely and fully take the function contained in the chew Sexual ingredients. - In the manufacture of functional chews of lozenges according to Articles 17 and 20 of the scope of the patent application, it is necessary to prepare polyphenols which are mixed with alcohol-soluble proteins by i~2〇% φ. A base material powder composed of a protein and a polyphenol, the base material powder may be added with a functional material, a sweetener, a fragrance, a lubricant, etc., and then subjected to tableting, or a base material powder, and functionality. A mixed powder composed of a material, a sweetener, a fragrance, a lubricant, or the like is subjected to dry granulation, followed by tableting, or a base material powder, a functional material, a sweetener, a fragrance, a lubricant, and the like. The powder is mixed, and the powdered paste is used as a binder, and granulated by a wet granulation method such as a fluidized layer granulation drying method, and the granules obtained after drying are added to a perfume, a lubricant, or the like, followed by tableting. A functional chew of the ingot φ agent. On the other hand, when manufacturing a functional chew of granules, 'the same preparation is required to mix i~2 〇% of the polyphenols relative to the prolamin'. The base material consisting of prolamin and polyphenols Powder, which may be added to a functional material, a sweetener, a fragrance, a lubricant, a dry granulation in a base material powder, or a mixed powder composed of a base material powder, a functional material, a sweetener, etc. The starch paste is used as a binder, and is granulated by a wet granulation method such as a fluidized layer granulation drying method, and the granules obtained after drying are added to a fragrance or the like to produce a functional chew of granules. The manufacturing steps of functional chews in the form of lozenges or granules can be used in the manufacturing steps of -24-200816932 (22) Pharmaceuticals and health foods. Flow layer granulation dryers, rotary flow machines. According to the general patent system of the base material raw material powder of the ninth aspect of the patent application, it is possible to produce a functional substance having a low moisture content and a functional substance having a high moisture content. The functional chews do not require mildew treatment, and do not need to be kneaded, calendered, etc., granulated, dried, and ingot to make the equipment of the invention with less moisture content and equipment used by the health food industry. Made into tablets and granules. In the case of the product, in the dry trial granulation method, it is not necessary to dry the granulator for granulation to produce granules for tableting. In the powder in the wet granulation method, the water granules are connected with the gelatinized starch or the like, and when the tablet is produced, the protein becomes viscous when it is hydrated to produce a clean manufacturing apparatus, and therefore, the granulation method is not used. As a functional anti-ground of the present invention, the manufacture consists of wet blocks, and it is also possible to use 20 kinds of commonly used preparations such as dry trial granulator, granulator, and tableting machine, which are composed of alcohol-soluble proteins and multi-addition functions. Sexual materials, etc., and then applied to the manufacturing method, with a very simple and practical chewing. Therefore, it is different from the wet-wet chew, and the special moisture-proof material is coated with sugar coating and film. Because it is made by general use, it can also greatly reduce the manufacturing cost of the chew. A pharmaceutical granulator, a dryer, a tableting machine, etc., which are functionally chewed and water-reduced with a small amount of water, and the mixed powder is used for granules, and the flow layer is granulated and dried in the production of the tablet. The solution is sprayed and the dried granules are produced for tableting. Further, due to the adhesiveness of the gluten, it is particularly preferable that the wet granulation method is not preferable to the granulation method which uses water as a dry chew of the binding liquid. Functional chews with high moisture content -25-200816932 (23) When 15~25% water is added to the raw material powder such as gliadin and then kneaded, the wet mass becomes extremely viscous, resulting in kneading. It is a burden and requires a large and powerful kneader as used in the manufacture of chewing gum. Further, in order to stretch these wet masses into a film and perform cutting, special equipment such as a calender roll and a cutting roll which are used in the production of chewing gum in the range of 2 to 3 stages are required. In addition, a functional chew which has a high moisture content, which is composed of a wet mass, is produced by hot air drying, and the granules obtained after the crushing are subjected to tableting to produce a tablet, which is required to be long because the wet block has high viscosity. At the same time, since the obtained particles are too hard and difficult to form, the moldability is poor, and it is difficult to efficiently produce the tablet, and the manufacturing cost is greatly increased. When the functional chew which is composed of a wet mass and has a high moisture content is freeze-dried, it is necessary to dry for a long time of 2 days or longer, and the 100,000 pieces of a small wet mass of about 1 mm of plate shape are stored in the frozen state. In the dryer, extremely complicated operations are required, and the manufacturing cost is remarkably increased as compared with the manufacturing method of the present invention which can ensure a daily output of 1 million spindles or more. The present application can be mixed with lactic acid bacteria and enzymes which are susceptible to moisture due to tableting or granulation under conditions of low water activity. When a functional component which is insoluble in water, such as an inorganic compound such as mixed dolomite, is formulated, the ratio of the substrate of prolamin/wheat gluten and the amount of polyphenols is adjusted to several minutes to 1 minute. The degree of chewing time, or by finely adjusting the weight of the chew by 300 to 400 mg per ingot, makes it easy to swallow, and can surely and sufficiently take in the functional ingredients contained in the chew. According to Articles 18, 19 and 20 of the scope of the patent application, when the functional chew of the tablet is manufactured, the ratio of the gliadin to the wheat gluten is -26-200816932 (24). 9 · ϋ"~2: 8, at the same time, in order to mix 20% of the phenols with the total amount of prolamin and wheat gluten, it is necessary to prepare alcohol-soluble proteins, wheat spoilage and polysaccharides. a base material powder composed of the base material powder, a functional material, a sweetener, a fragrance, a lubricant, etc., and then subjected to tableting, or a base material powder, a functional material, a sweetener, a fragrance A mixed powder composed of a lubricant or the like is subjected to dry granulation and then subjected to tableting, or a mixed powder of a base material powder, a functional material, a sweetener, a fragrance, a lubricant, etc., as a starch paste. As a binder, granulation is carried out by a wet granulation method such as a fluidized bed granulation drying method, and the granules obtained after drying are added to a perfume, a lubricant, or the like, followed by tableting, and the tablet is functionalized. Chews. On the other hand, when the functional chew of the granule is produced, the ratio of the ratio of the gliadin to the wheat bond is 9 · 9 : 〇 .  1~2: 8, at the same time, in order to mix the phenols with ~2〇% relative to the total amount of prolamin and wheat gluten, it is necessary to prepare alcohol-soluble proteins, wheat gluten and polyphenols. The base material powder of the composition may be added with a functional material, a sweetener, a fragrance, a Φ lubricant equal to the base material powder for dry granulation, or a base material powder, a functional material, a sweetener, etc. The mixed powder of the composition is prepared by a wet granulation method such as a fluidized layer granulation drying method using a mixed powder of a temple, and granulation is carried out by adding a granule obtained by drying to a fragrance or the like to produce granules. Chews. The manufacturing step of a functional chew in the form of a lozenge or granules can be used in the manufacturing steps of pharmaceuticals and health foods, and can also be carried out using a dry trial granulator, a flow layer granulation dryer, and a rotary flow. Common preparation machinery such as granulators and tableting machines. Therefore, according to the patent application scope No. 18, 19, 20, functional materials such as alcohol soluble egg -27-200816932 (25) white, wheat gluten and polyphenols are added to the base material powder. Then, a general preparation method such as granulation, drying, and tableting is applied, and a functional chew having a low moisture content can be produced with a very simple operation. Therefore, it is different from the functional chew which forms a high moisture content from the wet block, and the functional chew of the present invention having less moisture content does not need to be treated by the sugar coating and the film coating, and does not need to be kneaded. Special equipment such as calendering is manufactured by granulation, drying and tableting, which are highly versatile, and can also greatly reduce manufacturing costs. The functional chews having a small moisture content of the present invention can be produced into tablets and granules using equipment such as a granulator, a dryer, and a tablet machine which are widely used in the pharmaceutical industry and the health food industry. When a functional chew having a small moisture content is produced, in the dry trial granulation method, the granules are produced by granulating the mixed powder by a dry trial granulator without adding water, and the granules are further produced when the tablet is manufactured. Make ingots. In the wet granulation method, the fluidized layer granulation drying method is carried out by spraying an aqueous solution of a gelatinized starch or the like onto a raw material powder to produce dried granules, and the granules are further tableted in the production of a tablet. In addition, since the gelatin protein becomes sticky when it contains water, it is difficult to clean the manufacturing equipment by the wet granulation method, and therefore, the dry granulation method which does not use water as a binding liquid is used as the present invention. The granulation method of functional chews is particularly good. Conversely, when a functional chew having a high moisture content composed of a wet mass is produced, when 15 to 25% of water is added to the raw material powder such as gliadin and kneaded, the wet mass becomes extremely viscous, resulting in The burden at the time of kneading requires a large and powerful kneader as used in the manufacture of chewing gum. Further, in order to stretch these wet masses into a film and then cut them, special equipment such as a calender roll and a cutting roll which are used in the manufacture of the fragrant -28-200816932 (26) sugar is required. In addition, the production of a functional chew which is composed of a wet mass and having a high moisture content is subjected to hot air drying, and the granules obtained after the crushing are subjected to tableting to produce a tablet, which is required to be long because of the high viscosity of the wet mass. The drying of time, " At the same time, because the obtained particles are too hard and difficult to form, the formability is not good, and it is difficult to manufacture the tablet efficiently, and of course, the manufacturing cost is greatly increased. When the functional chew which is composed of a wet mass and has a high moisture content is freeze-dried, φ needs to be dried for a long time of 2 days or longer, and 100,000 pieces of a small wet cake having a plate shape of about 10 mm are stored in a freeze-dried state. In the machine, an extremely complicated operation is required, and the manufacturing cost is remarkably increased as compared with the manufacturing method of the present invention which can ensure a daily output of 1 million or more. The present application can be mixed with lactic acid bacteria and enzymes which are susceptible to moisture due to tableting or granulation under conditions of low water activity. In the case of a water-soluble solid functional ingredient, such as a compound of an inorganic compound such as mixed dolomite, the ratio of the substrate of the prolamin/wheat gluten and the amount of the polyphenols is adjusted to Φ to several minutes. The degree of chewing time in minutes, or by finely adjusting the weight of the chews by 300 to 400 mg per ingot, makes it easy to swallow, and can surely and sufficiently take in the functional ingredients contained in the chew. As shown in Item 21 of the scope of the present application, in the application of Patent No. 15, 17 or 18, when mixing 1 to 40% of the protease, the chewing time can be adjusted to produce a functional chew. . As shown in item 22 of the scope of the present application, in the case of the fifteenth, seventeenth or eighteenth aspect of the patent application, when 5 to 40% of the disintegrating agent is mixed, the chewing time can be adjusted to produce a functional chew. -29- 200816932 (27) Further, a method of using the functional chew of the present invention will be described. Item 23 of the scope of the patent application of the present invention relates to a method of using a functional chew, which is functional as described in any one of claims 1 to 8 and/or claim 1 After the chew, add chewing - as described in the functional chew of item 11 of the patent application. Item 24 of the patent application of the present invention relates to a method for using a functional φ chew, which is chewed as a functional chew according to claim 9 of the patent application, and further chewed as claimed. 1 1 consists of a functional chew. Item 25 of the scope of the present invention relates to a method of using a functional chew, which is a functional chew which is chewed according to any one of claims 1 to 8 or 1 , chewing time is more than 1 〇 minutes, and then add a chewing chew or a functional chew with a chewing time of 2 minutes or less. φ The scope of claim 26 of the present invention relates to a method for using a functional chew which chews a functional chew as in claim 9 of the patent application, and the chewing time is more than 1 minute, and then It is composed of a solid chew or a functional chew with a chewing time of 2 minutes or less. Claim No. 27 of the scope of the present application is a method for using a functional chew according to claim 25 or 26, wherein the proportion of the solid chewable gliadin or gliadin to wheat gluten For a weight ratio of 9. 9: 0. 1 ~ 8. 1: 1. 9. -30- 200816932 (28) The scope of claim 28 of the present invention relates to a method of using a functional chew, which is chewed as in any one of claims 1 to 8 or 1 of the patent application. A functional chew, which has a chewing time of more than 10 minutes, and is further composed by chewing an organic acid lozenge. - The scope of claim 29 of the present invention relates to a method of using a functional chew which chews a functional chew as claimed in claim 9 and has a chewing time of 1 以上 or more. It is further composed by adding a φ chewing organic acid lozenge. The third aspect of the patent application scope of the present invention is a method for using a functional chew according to claim 28 or 29, wherein the organic acid is derived from citric acid, malic acid, tartaric acid, succinic acid, gluconic acid, It is composed of at least one selected from the group consisting of lactic acid and acetic acid. The third aspect of the patent application of the present invention relates to a method of using a functional chew, which is chewed as a functional chew according to any one of claims 1 to 8 or 1 of the patent application. The chewing time is 1 〇 φ min or more, and then the chewing fast disintegrating disintegration is added. Item 32 of the patent application of the present invention relates to a method of using a functional chew which chews a functional chew as claimed in claim 9 of the patent application, and the chewing time is 10 minutes or more. And then re-chasing / adding chewing and disintegrating the ingot to form. The third aspect of the patent application of the present invention relates to a method for using a functional chew according to claim 31 or 32, wherein the fast disintegrating tablet contains a selected from the group consisting of citric acid, malic acid, tartaric acid, Succinic acid, gluconic acid, lactic acid, acetic acid, ascorbic acid organic acid, gelatin, casein-31 - 200816932 (29) sodium, collagen protein, carrageenan, sanxian gum, gellan gum, tragacanth, Acacia, sodium carboxymethylcellulose, calcium hydroxymethylcellulose, a polysaccharide of sodium alginate, at least one of polyglutamic acid, arginine, cocoa powder, and cheese powder. - as shown in item 23 of the scope of the patent application of the present invention, after chewing as a functional chew of any one of the claims 1 to 8 or 10 of the patent scope, additional chewing as claimed In the case of the functional φ chew of item 11, the proteolytic enzyme agent of claim 11 is made to make the elasticity and the aggregation smaller and easy to separate, and the chewing time can be adjusted according to the preference due to shortening the chewing time. As a result, functional chews are easily swallowed, and it is desirable to maintain and improve health or restore health. It is even more appropriate to treat the disease. As shown in item 24 of the patent application of the present invention, after chewing a functional chew as in claim 9 of the patent application, when further chewing a functional chew as in claim 11 of the patent application, The protein-decomposing enzyme agent of the application scope 11 makes the elasticity and the aggregation less easy to separate, and the chewing time can be adjusted according to the preference by shortening the chewing time, and the result becomes a functional chew. Ingestion, and can be expected to maintain and improve health or restore health. Further, the treatment of the disease can be performed more appropriately, as shown in item 25 of the scope of the invention of the present invention, chewing a functional chew as claimed in any one of claims 1 to 8 or 1 , chewing time is more than 1 , minutes, and then add a chewing chew or a functional chew with a chewing time of 2 minutes or less, with a chewing time of 2 minutes or less by -32-200816932 (30) Solid chews or functional chews, changing their ratio to prolamin or polyphenols, easy to separate by making the elasticity and aggregation smaller, shortening chewing time, adjusting chewing according to preference The result of the time is that the functional chews are highly chewable and "swallowable", and it is desirable to maintain and improve health or restore health, and to treat the disease more appropriately. To explain in more detail, for example, a sleep-preventing article used for driving, the initial chewing time is a suitable 30 minutes required to add a Φ nicotine lozenge, for example, when chewed for 30 minutes, and then chewed by additional chewing. The vitamin-added tablet has a chewing time of 2 minutes or less, and the chew is less elastic and aggregated in 2 and 3 minutes, and is dispersed, and even a woman can easily forage. As shown in item 26 of the patent application of the present invention, chewing a functional chew as in claim 9 of the patent application, the chewing time is more than 10 minutes, and then the addition of the chewing and chewing time is 2 minutes or less. In the case of a chew or a functional chew, by changing the ratio of the ratio to the prolamin or the ratio of polyphenols to a solid chew or a functional chew with a chewing time of 2 minutes. Since the elasticity and the aggregability are made small, it is easy to separate, and the chewing time can be adjusted according to the preference by shortening the chewing time, and as a result, the chewable property of the functional chew is doubled, and the chewability and the ingestibility become two. 1 ' It is expected to maintain and improve health or restore health, and to treat diseases more appropriately. To explain in more detail, for example, a sleep-preventing article used for driving, the initial chewing time is a suitable 30 minutes required to add a nicotine tablet, for example, when it is annoying after 30 minutes of chewing, and then added by chewing. Vitamin tablets and their chewing time is less than 2 minutes. Chewing -33-200816932 (31) The elasticity and aggregation of the objects become smaller and dispersed in 2 and 3 minutes, even for women. As shown in item 27 of the scope of the present invention, in the scope of claim 25 or 26, the solid chew is a gliadin or a alcohol-soluble egg. The ratio of white to wheat gluten is 9. 9 ·· 0. 1~8. 1 : 1. 9, when, borrow * by simply changing the ratio of prolamin or polyphenols. The elasticity and assembly are made smaller and easy to disperse, and the chewing time is shortened so that the chewable substance having a function of Φ can be easily swallowed. As shown in item 28 of the scope of the invention of the present invention, a chew having a functional chew of any one of claims 1 to 8 or item 10 of the patent application has a chewing time of 1 minute or more, and is further added. When chewing an organic acid lozenge, the organic acid component contained in the tablet can make the elasticity and the assembly property smaller and easy to disperse, shorten the chewing time, and adjust the chewing time according to the preference, and the result is functional. Chews have high chewability and swallowability, and can be expected to maintain and improve health or restore health, and more appropriately treat diseases. As shown in item 29 of the patent application of the present invention, a functional chew which is chewed according to claim 9 of the patent application has a chewing time of 1 〇 minute or more, and when the chewing organic acid lozenge is further added, The y organic acid component contained in the tablet makes the elasticity and the aggregation smaller and is easy to disperse, shortens the chewing time, and adjusts the chewing time according to the preference, and the result is that the functional chew is highly chewable and can be used. Swallowing becomes two. It is expected to maintain and improve health or return to health, as well as more appropriate treatment of the disease. As shown in item 30 of the patent application of the present invention, the patent application No. 34-200816932 (32), in item 28 or 29, is derived from citric acid, succinic acid, gluconic acid, lactic acid, and organic acids. The choice of acetic acid makes the elasticity and aggregation less and is easy to disperse, and the chewable property of chewing can be easily swallowed. According to any one of the items 1 to 8 or 10 of the patent scope of the invention, the chewing time is 10 minutes or more, and the time is again chased, and the ingot is rapidly disintegrated. The ingredients contained are such that the elasticity and dispersion are dispersed, the chewing time is shortened, and the fruit can be adjusted according to preference. The chewable substance has a high chewability and can be swallowed and can be expected to maintain and improve health or restore health, and treat the disease. To describe in more detail, for example, a sleeping product, the initial chewing time is 30 minutes after the addition of Nikko, for example, after chewing for 30 minutes, it is felt to chew the vitamin-added tablet and the chewing time is 2, 3 In the minute, the elasticity and the aggregation become smaller, and the sex can be easily swallowed. A functional chew according to item 9 of the scope of claim 32 of the present invention, when the cuckoo clock is re-added to the chewing and disintegrating tablet, the composition and the composition are made smaller. Easy to disperse' can adjust the chewing time according to preference, and the result is that it has high chewiness and swallowability, which can be used for health or wellness, and more suitable for diseases, malic acid and tartar. At least one kind of time becomes shorter and makes a good show. If the chewing and chewing fast disintegrating ingots are applied, the chewability becomes small and easy to chew, and the feeding ability becomes two, and the driving is more suitable. When it is necessary to prevent the use of the tablet, the amount of the tablet can be dispersed by sticking for 2 minutes or less, even if it is a female, chewing as an application. The chewing time is 10 minutes. It is shortened in the fast disintegrating tablet, shortening the chewing time. The functional chew is expected to maintain and improve the health treatment. More specifically -35- 200816932 (33) This is a description of the anti-sleeping products used in, for example, driving, and the initial chewing time is 30 minutes for a nicotine-added lozenge, for example, after being chewed for 30 minutes. Then, by additionally chewing the vitamin-added tablet and the chewing time is less than 2 minutes, the chew is less elastic and aggregated in 2, 3 minutes, and is dispersed, even for women, it is easy to swallow. As shown in claim 33 of the present invention, in the scope of claim 31 or 32, the fast disintegrating tablet is selected from the group consisting of citric acid, malic acid, tartaric acid, succinic acid, gluconic acid, lactic acid, acetic acid, Ascorbic acid organic acid, gelatin, casein sodium, collagen protein, carrageenan, sanxian gum, gellan gum, tragacanth, agar, sodium carboxymethylcellulose, calcium hydroxymethylcellulose, When at least one of polysaccharides of sodium alginate, polyglutamic acid, arginine, cocoa powder, and cheese powder is used, the chewing time is adjusted by making the elasticity and aggregation less small, and the chewing time is adjusted. Functional chews can be easily swallowed. When chewing the functional chew of the present invention, the chewing time is longer than the soft candy and the number of chewing is increased, and the functional material can be taken up without being discarded because it is edible, and can be appropriately maintained. Or reply to health. At the same time, the treatment of the disease can be carried out appropriately. Further, since it has an edible property, it is possible to obtain an excellent effect of preventing environmental pollution problems such as dropping chewing gum. [Embodiment] Embodiments The present invention has the following embodiments. -36- 200816932 (34) Example 1 In [Example 1], mixed gliadin-type gliadin (gumin fraction), active gluten of wheat gluten (vitamin gluten) and function The xylitol and calcium stearate (lubricant) of the material, the ratio of the glutenin to the gluten is investigated by the following formula, and the formability and physical properties of the functional chewable tablet are also known. To what extent does chewing time (minutes), elasticity and stretch have an effect? In the tablet, a static compressor was used, and about φ was an ingot diameter of 15 mm, a single spindle of 100 mg, and a tablet hardness of 4 to 5 kg/cm 2 were produced, and each evaluation item described below was evaluated. (1) Formability Determine the hardness of the tablet. 〇·· The hardness of the tablet is 4 to 5 kg/cm 2 or more. △: The hardness of the tablet was 3 kg/cm2 or higher. X: The hardness of the tablet is 2 kg/cm2 or less, and even if it is made into an ingot, it is easily broken, and it is difficult to use it as a tablet. (2) Physical properties (a) Chewing time τ Chew 1 spindle of functional chewing at a rate of 70 to 80 times in 1 minute, and measure the time from dispersing to feeding for chewing time (minutes). "15 minutes or more" is a piece of aggregate that has not been dispersed after 15 minutes of chewing. 0 (b) Elasticity -37- 200816932 (35) Investigate the chewing time evaluation before about 2 minutes or after chewing for 10 minutes. status. ◎: It is strong in elasticity and forms a strong rubber block. 〇: A piece of rubber that is slightly soft and forms a single piece. ~ : Blocks that are weak and dry and flat. (c) Extensibility φ Before the chewing time was evaluated about 2 minutes or after 10 minutes of chewing, the chew was bitten by the teeth and the state was elongated with the fingers. ◎: It can be extended by more than l〇cm. 〇: It can be extended by about 5 c m. △: It can be stretched by about 3cm. X : Can be pulled up to 1 cm or can not be stretched. -38 - 200816932 (36) [Table 1]

實驗編號 01 02 03 04 05 06 07 08 09 10 11 麥膠蛋白麵 10/0 9/1 8/2 7/3 6/4 5/5 4/6 3/7 2/8 1/9 0/10 麥膠蛋白分劃物(g) 4.0 3.6 3.2 2.8 2.4 2.0 1.6 1.2 0.8 0.4 0 維生麩質(g) 0 0.4 0.8 1.2 1.6 2.0 2.4 2.8 3.2 3.6 4.0 補醇(g) 2 2 2 2 2 2 2 2 2 2 2 硬酯酸鈣(g) 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 成形性 〇 〇 〇 〇 〇 〇 〇 〇 Δ X X 咀嚼時間(分鐘) 1.5 2.5 4 5.5 8 15 以上 15 以上 15 以上 15 以上 15 以上 15 以上 彈性 〇 〇 〇 〇 〇 〇 〇 〇 Δ- 〇 △— 〇 △— 〇 伸展性 一 一 ◎ ◎ ◎ ◎ ◎ 〇 Δ X X 一:咀嚼時間過短,難以評價伸展性。Experiment number 01 02 03 04 05 06 07 08 09 10 11 Wheat gelatin surface 10/0 9/1 8/2 7/3 6/4 5/5 4/6 3/7 2/8 1/9 0/10 Gum protein fraction (g) 4.0 3.6 3.2 2.8 2.4 2.0 1.6 1.2 0.8 0.4 0 Vitamin gluten (g) 0 0.4 0.8 1.2 1.6 2.0 2.4 2.8 3.2 3.6 4.0 supplemental alcohol (g) 2 2 2 2 2 2 2 2 2 2 2 Calcium stearate (g) 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 Formability 〇〇〇〇〇〇〇〇Δ XX Chewing time (minutes) 1.5 2.5 4 5.5 8 15 or more 15 or more 15 or more 15 Above 15 or more and 15 or more elastic 〇〇〇〇〇〇〇〇 Δ- 〇 △ 〇 〇 — 〇 〇 性 一 ◎ ◎ ◎ ◎ ◎ 〇 Δ XX A: The chewing time is too short, it is difficult to evaluate the stretchability.

自以上結果,於麥膠蛋白分劃物/活性麩質之比例爲 10/0(實驗編號01)與9/1(實驗編號02)中,咀嚼時間過短 ,麥膠蛋白分劃物/活性麩質之比例爲1/9(實驗編號10)與 〇/1〇(實驗編號11)則難以成形爲錠劑。因此,所得之錠劑 之具功能性咀嚼物,其麥膠蛋白分劃物/活性麩質之比例 範圍在8/2(實驗編號03)與2/8(實驗編號09),明顯得知醇 溶蛋白類與小麥麩質之比例係以重量比爲8 : 2〜2 : 8之範 圍。 實施例2 於〔實施例2〕中,相對於醇溶蛋白類之麥膠蛋白(麥 膠蛋白分劃物)、小麥麩質之活性麩質(維生麩質),倂用以 〇.2g之量添加之多酚類之兒茶素,以〔實施例1〕約略相 -39- 200816932 (37) 同地,以下述之標準配方調查多酚類之兒茶素,對於具機 能性咀嚼物打錠時之成形性、及其物性,亦即爲咀嚼時間 (分鐘)、彈性及伸展性具何種程度的影響。兒茶素之總多 酚含量係90.4%,沒食子兒茶素沒食子酸脂(EGCg)含量係 : 4 7 · 4 % 〇 〔表2〕From the above results, in the ratio of gliadin/active gluten to 10/0 (experiment No. 01) and 9/1 (experiment No. 02), the chewing time is too short, gliadin fraction/activity The ratio of gluten is 1/9 (experiment No. 10) and 〇/1〇 (experiment No. 11) is difficult to form into a tablet. Therefore, the functional chew of the obtained tablet has a ratio of gliadin/active gluten ranging from 8/2 (experiment No. 03) and 2/8 (experiment No. 09), and it is apparent that alcohol The ratio of lysin to wheat gluten is in the range of 8:2 to 2:8 by weight. Example 2 In [Example 2], the gliadin (gliadin fraction) of the prolamin and the active gluten of the wheat gluten (vitamin gluten) were used for 2.2g. The polyphenolic catechin was added in an amount of about [0086] in the same manner as in [Example 1], and the polyphenolic catechin was investigated in the following standard formula for the functional chewables. The formability and physical properties of the ingot, that is, the degree of chewing time (minutes), elasticity and stretchability. The total polyphenol content of catechins was 90.4%, and the content of gallic catechin gallate (EGCg) was: 4 7 · 4 % 〔 [Table 2]

實驗編號 21 22 23 24 25 26 27 28 29 30 31 麥膠蛋白廢質 10/0 9/1 8/2 7/3 6/4 5/5 4/6 3/7 2/8 1/9 0/10 麥膠蛋白分劃物(g) 4.0 3.6 3.2 2.8 2.4 2.0 1.6 1.2 0.8 0.4 0 維生麩質(g) 0 0.4 0.8 . 1.2 1.6 2.0 2.4 2.8 3.2 3.6 4.0 兒茶素(g) 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 木糖醇(g) 2 2 2 2 2 2 2 2 2 2 2 硬酯酸鈣(g) 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 成形性 〇 〇 〇 〇 〇 〇 〇 〇 Δ X X 阻嚼時間(分鐘) 15 15 15 15 15 15 15 15 15 糊狀 糊狀 以上 以上 以上 以上 以上 以上 以上 以上 以上 彈性 〇 〇 ◎ ◎ ◎ ◎ ◎ ◎ ◎ 伸展性 ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ 糊狀:咀嚼錠劑時直接變爲粉狀,含唾液後變爲泥狀物。 如上所述,多酚類(兒茶素)會使麥膠蛋白分劃物中之 蛋白質凝集、集合,其結果係可得麥膠蛋白分劃物比例大 者,即麥膠蛋白分劃物/維生麩質=10/0〜6/4之基材組成(試 驗編號21〜2 5)中,咀嚼時間增長爲15分鐘以上,且富含 彈性及伸展性之咀嚼物。於其他基材組成亦增加其彈性。 進而,麥膠蛋白分劃物僅佔一成或僅含有維生麩質之基材 組成(試驗編號30、31)中,未發現兒茶素之蛋白質集合作 -40- 200816932 (38) 用所引起的物性改善效果’亦未提升錠劑之成形性。可利 用爲具機能性之咀嚼物之基材組成係麥膠蛋白分劃物/維 生麩質=10/0〜2/8之基材組成。 因此,所得之具功能性咀嚼物’以相對於醇溶蛋白類 與小麥麩質之合計量(4.0g),以5%之多酚類(0.20g兒茶 素)狀態下,麥膠蛋白分劃物/活性麩質之比例範圍在1 0/0 到2/8,明顯得知醇溶蛋白類與小麥麩質之比例可落在重 量比爲9.9 : 0.1〜2 : 8之範圍。 實施例3 於〔實施例3〕’相對於醇溶蛋白類之麥膠蛋白(麥膠 蛋白分劃物)、小麥麩質之活性麩質(維生麩質)’倂用以 0.1 〇g之量添加之多酚類之兒茶素’以〔實施例1〕及〔 實施例2〕約略相同地’以下述之標準配方調查多酿類之 兒茶素,對於具機能性咀嚼物打錠時之成形性、及其物性 ,亦即爲咀嚼時間(分鐘)、彈性及伸展性具何種程度的影 響。兒茶素之總多酚含量係9 0 · 4 %,沒食子兒茶素沒食子 酸脂(EGCg)含量係47.4%。 -41 - 200816932 (39) 〔表3〕 實驗編號 41 42 43 44 45 46 47 48 49 50 51 52 麥膠蛋白願 10/0 9/1 8.5/1.5 8/2 7/3 6/4 5/5 4/6 3/7 2/8 1/9 0/10 麥膠蛋白分劃物(g) 4.0 3.6 3.4 3.2 2.8 2.4 2.0 1.6 1.2 0.8 0.4 0 維生麩質(g) 0 0.4 0.6 0.8 1.2 1.6 2.0 2.4 2.8 3.2 3.6 4.0 兒茶素(g) 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 機醇(g) 2 2 2 2 2 2 2 2 2 2 2 2 硬酯酸鈣(g) 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 成形性 〇 〇 〇 〇 〇 〇 〇 〇 〇 Δ X X 咀嚼時間(分鐘) 4 7 10 15 以上 15 以上 15 以上 15 以上 15 以上 15 以上 15 以上 糊狀 .r»rjrrf 糊狀 彈性 〇 〇 〇 〇 ◎ ◎ © ◎ ◎ ◎ 伸展性 ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ 〇Experiment No. 21 22 23 24 25 26 27 28 29 30 31 Gliadin waste 10/0 9/1 8/2 7/3 6/4 5/5 4/6 3/7 2/8 1/9 0/ 10 Gliadin fraction (g) 4.0 3.6 3.2 2.8 2.4 2.0 1.6 1.2 0.8 0.4 0 Vitamin gluten (g) 0 0.4 0.8 . 1.2 1.6 2.0 2.4 2.8 3.2 3.6 4.0 catechin (g) 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Xylitol (g) 2 2 2 2 2 2 2 2 2 2 2 Calcium stearate (g) 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 Formability〇〇〇〇〇〇〇 〇Δ XX Chewing time (minutes) 15 15 15 15 15 15 15 15 15 Paste paste or more or more or more or more or more 〇〇 ◎ ◎ ◎ ◎ ◎ ◎ ◎ Stretching ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ Paste: When chewing the tablet, it will become powdery, and it will become mud after containing saliva. As described above, polyphenols (catechins) cause agglomeration and aggregation of proteins in the gliadin fraction, and as a result, a ratio of gliadin fractions is large, that is, gliadin fractions/ In the substrate composition of the gluten-free gluten = 10/0 to 6/4 (test No. 21 to 2 5), the chewing time was increased to 15 minutes or more, and the chews which were rich in elasticity and stretchability were obtained. Composition with other substrates also increases its elasticity. Furthermore, the gliadin fractions only accounted for 10% or only the substrate composition containing the gluten-free gluten (test No. 30, 31), and no catechin protein group cooperation was found -40-200816932 (38) The physical property improvement effect 'does not improve the formability of the tablet. It can be used as a substrate composition of a functional chewable material, a gliadin fraction/main gluten = 10/0 to 2/8. Therefore, the obtained functional chews are based on the total amount of gliadin and wheat gluten (4.0 g), and in the state of 5% polyphenols (0.20 g catechin), gliadin. The ratio of the scoring/active gluten ranges from 10/0 to 2/8, and it is apparent that the ratio of the prolamin to the wheat gluten may fall within the weight ratio of 9.9:0.1 to 2:8. Example 3 [Example 3] 'About gliadin-type gliadin (micin fraction), wheat gluten-active gluten (vitamin gluten)' is used in an amount of 0.1 〇g The added polyphenolic catechins were investigated in the same manner as in [Example 1] and [Example 2] by the following standard formula, for the functional chewing of tablets. Formability and physical properties, that is, the degree of chewing time (minutes), elasticity and stretchability. The total polyphenol content of catechin was 9.0%, and the content of gallic catechin gallate (EGCg) was 47.4%. -41 - 200816932 (39) [Table 3] Experiment No. 41 42 43 44 45 46 47 48 49 50 51 52 Gum Protein 10/0 9/1 8.5/1.5 8/2 7/3 6/4 5/5 4/6 3/7 2/8 1/9 0/10 Gliadin fraction (g) 4.0 3.6 3.4 3.2 2.8 2.4 2.0 1.6 1.2 0.8 0.4 0 Vitamin gluten (g) 0 0.4 0.6 0.8 1.2 1.6 2.0 2.4 2.8 3.2 3.6 4.0 catechin (g) 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Alcohol (g) 2 2 2 2 2 2 2 2 2 2 2 2 2 Calcium stearate (g) 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 0.06 Formability 〇〇〇〇〇〇〇〇〇Δ XX Chewing time (minutes) 4 7 10 15 or more 15 or more 15 or more 15 or more 15 or more 15 or more 15 or more paste.r»rjrrf paste ○ ○ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ 〇 〇

如上述結果,以〔實施例2〕1/2的0.10g之兒茶素, 於麥膠蛋白分劃物比例高之基材組成(試驗編號41〜43), 咀嚼時間縮短爲1 〇分鐘以下,彈性亦稍微變弱。此時得 到不會過度停留於口中之咀嚼物。可利用爲機能性咀嚼物 之基材組成,係麥膠蛋白分劃物/維生麩質=10/0〜2/8。 因此,所得之具功能性咀嚼物,以相對於醇溶蛋白類 與小麥麩質之合計量(4.0g),以2.5%之多酚類(0.1 〇g兒茶 素)狀態下,麥膠蛋白分劃物/活性麩質之比例範圍在1 〇/〇 到2/8,明顯得知醇溶蛋白類與小麥麩質之比例可落在重 量比爲9·9 : 0.1〜2 : 8之範圍。 自〔實施例1〕〜〔實施例3〕之結果可明確得知,影 響機能性咀嚼物物性的因子,係基材組成(麥膠蛋白分劃 物/維生麩質之比例),及兒茶素等多酚之混合量。 -42- 200816932 (40) 實施例4 於〔實施例4〕中,因調查咀嚼本發明之機能性咀嚼 物物性時機能性成分溶出情形,而選擇水溶性物質之咖啡 因’及脂溶性物質之維他命E(醋酸生育酚),使用做爲範 本之〔表4〕及〔表5〕之原料進行打錠,而得錠徑13mm ,1錠重量爲〇 · 6 g之錠劑。As a result of the above, with 0.10 g of catechin of 1/2 of [Example 2], the composition of the substrate having a high proportion of the gliadin fraction (test Nos. 41 to 43), the chewing time was shortened to 1 〇 or less. The elasticity is also slightly weaker. At this point, you get a chew that doesn't stay too much in your mouth. It can be used as a substrate composition for functional chews, which is a gliadin fraction/living gluten = 10/0~2/8. Therefore, the obtained functional chew is obtained in a total amount of 2.5% polyphenols (0.1 〇g catechin) relative to gliadin and wheat gluten (4.0 g), and gliadin The ratio of fractions/active gluten ranges from 1 〇/〇 to 2/8. It is obvious that the ratio of prolamin to wheat gluten can fall within the weight ratio of 9·9 : 0.1~2 : 8 . From the results of [Example 1] to [Example 3], it is clear that the factor affecting the physical properties of the functional chew is the substrate composition (the ratio of the gliadin fraction/vitamin gluten), and the catechu tea. The amount of polyphenols mixed. -42- 200816932 (40) Example 4 In [Example 4], the caffeine of the water-soluble substance and the fat-soluble substance were selected by investigating the dissolution of the functional ingredient when chewing the physical properties of the functional chew of the present invention. Vitamin E (tocopherol acetate) was used as a raw material for the sample [Table 4] and [Table 5], and a tablet having a spindle diameter of 13 mm and a spindle weight of 〇·6 g was obtained.

〔表4〕 原料名稱 混合量(g) 醇溶蛋白類(麥膠蛋白) 48.0 小麥麩質(維生麩質) 12.0 多酚類(兒茶素) 4.0 功能性材料(菊糖、醋酸生育酚) 29.5 甜味劑 3.0 潤滑劑、促進流動劑 3.5 〔表5〕 原料名稱 混合量(2) 醇溶蛋白類(麥膠蛋白) 48.0 小麥麩質(維生麩質) 12.0 多酚類(兒茶素) 3.5 功能性材料(菊糖、醋酸生育酚) 30.5 甜味劑 3.0 潤滑劑、促進流動劑 — 因咀嚼而造成之功能性成分溶出模式係以下述方法測 定。於規定時間咀嚼1錠錠劑後,將咀嚼物以水簡單清洗 -43 - 200816932 (41) 後測定重量,其完成水洗之咀嚼物約l〇〇mg且需正確測量 其重量。針對咖啡因錠與醋酸生育酚錠進行入下述之前處 理而調製試樣溶液,再定量各別之成分後求出殘存率(%) ,其次以(100—殘存率(%))而計算出溶出率(%),求得溶 出模式。其結果示於圖1。 咖啡因錠: % 於約1 OOmg經正確測量後之完成水洗咀嚼物中,加入 0.02N氫氧化鈉之30%甲醇水溶液40mL,同時置於硏缽 中搗碎並使其溶解。取該溶解液加入5〇mL之定量量瓶中 ,再加6mL之0.2N鹽酸及加水至總體積爲50mL並加以 混合後,進行離心分離(3〇〇〇rpm,5分鐘),將所得之上清 液做爲試樣溶液。取該試樣溶液藉HPLC法定量咖啡因。 咀嚼時間分別爲〇分鐘、2分鐘、5分鐘、10分鐘及20分 鐘,分別重覆進行3次試驗,定量咀嚼物中殘存的咖啡因 % ,依其3次的平均値求得殘存率(%),再依此計算出溶出 率(% ),求得溶出模式。 醋酸生育酚錠: ' 於約1 OOmg經正確測量後之完成水洗咀嚼物中,加入 0.02N氫氧化鈉之30%甲醇水溶液40mL,同時置於硏缽 中搗碎,使其溶解並加水至總體積爲50mL且力Q以混合。 取該溶液l〇mL,加入90%之乙醇震盪5分鐘後,再加水 至總體積爲5 OmL且加以混合後,進而進行1 〇分鐘之超音 -44- 200816932 (42) 波處理。將該溶液進行離心分離(3 0 0 0 rp m,5分鐘),將所 得之上清液做爲試樣溶液。取該試樣溶液藉HPLC法定量 醋酸生育酚。於試樣溶液調製中因以生育酚取代一部分的 醋酸生育醇,需定量醋酸生育酚及生育酚二者,由二者莫 β 耳數之和而求出醋酸生育酚量。咀嚼時間分別爲0分鐘、 - 2分鐘、5分鐘、10分鐘、20分鐘、30分鐘、45分鐘及 6〇分鐘,分別重覆進行3次試驗,定量咀嚼物中殘存的醋 φ 酸生育酚,依其3次的平均値求得殘存率(%),再依此計 算出溶出率(%),求得溶出模式。 自圖1可明顯得知水溶性物質之咖啡因,咀嚼1 0分 鐘後約有8成,20分鐘後約有9成被溶出。反之,脂溶性 物質之醋酸生育酚,咀嚼10分鐘後約有4成,20分鐘後 約有6成,30分鐘後約有7成,45分鐘後約較低於9成 ,6 0分鐘後超過9成被溶出,但較咖啡因遲溶出。因此, 可明確得知藉由咀嚼可攝取功能性材料之功能性成分。 • 實施例5 〔實施例5〕係咀嚼本發明之具功能性咀嚼物,確認 ^ 於吞食後經消化道完全消化之結果。使用〔表6〕所示之 原料進行打錠,得錠徑13mm,1錠重量爲〇.6g之錠劑。 ' 如下述方式進行人類消化試驗。針對8位自願受試者 ,毎位均於餐後服用1〜2錠,毎日5錠,3日共15錠。自 服用咀嚼物之第二日起,至服用完畢之第3曰共5曰’採 取自願受試者每日之全量糞便,觀察、仔細分辨是否有來 自咀嚼物之白色塊狀被排泄於糞便中。其結果’ 8位自願 -45- 200816932 (43) 受試者的糞便中,並未發現來自咀嚼物之爲消化的白色塊 狀。 本發明之具功能性咀嚼物確認可於來自豬胃黏膜之胰 蛋白酶所構成之人工胃液,及來自豬胰臟之胰酶所構成之 -人工腸液中被消化。因此,明確得知具功能性咀嚼物具可 - 食性,同時可完全於消化道中被消化,且確實吸收功能性 材料的功能性成分。 〔表6〕 原料名稱 混合量(g) 醇溶蛋白類(麥膠蛋白) 48.0 小麥麩質(維生麩質) 12.0 多酚類(兒茶素) 3.3 功能性材料(菊糖、具孢子性乳酸、比菲 德氏菌) 25.0 甜味劑 3.0 著色劑(氧化鈦) 3.0 香料 3.0 潤滑劑、促進流動劑 2.7[Table 4] Mixing amount of raw material name (g) Glycol protein (gumin) 48.0 Wheat gluten (vitamin gluten) 12.0 Polyphenols (catechin) 4.0 Functional materials (inulin, tocopherol acetate) 29.5 Sweetener 3.0 Lubricant, flow promoting agent 3.5 [Table 5] Mixing amount of raw material name (2) Glycol protein (gumin) 48.0 Wheat gluten (vitamin gluten) 12.0 Polyphenols (catechin) 3.5 Functional materials (inulin, tocopherol acetate) 30.5 Sweetener 3.0 Lubricant, flow-promoting agent - The functional ingredient dissolution mode due to chewing is determined by the following method. After chewing 1 tablet of the tablet at a prescribed time, the chew is simply washed with water -43 - 200816932 (41) and the weight is measured, and the washed chew is about 1 mg and the weight is correctly measured. The caffeine ingot and the tocopherol acetate ingot were prepared by the following treatment to prepare a sample solution, and the respective components were quantified to determine the residual ratio (%), and then calculated by (100 - residual ratio (%)). The dissolution rate (%) was determined by the dissolution mode. The result is shown in Fig. 1. Caffeine ingot: % After about 10,000 mg of the properly measured washed chew, 40 mL of a 30% aqueous methanol solution of 0.02 N sodium hydroxide was added, and the mixture was chopped and dissolved in a crucible. The solution was added to a 5 mL mL quantitative bottle, and 6 mL of 0.2 N hydrochloric acid was added thereto, and water was added to a total volume of 50 mL and mixed, followed by centrifugation (3 rpm, 5 minutes), and the resulting solution was obtained. The supernatant was used as a sample solution. The sample solution was taken to quantify caffeine by HPLC. The chewing time was 〇 minute, 2 minutes, 5 minutes, 10 minutes and 20 minutes, respectively, and repeated tests were carried out 3 times to quantify the residual caffeine % in the chew, and the residual rate was obtained according to the average of 3 times. Then, the dissolution rate (%) was calculated from this, and the dissolution mode was determined. Tocopherol acetate ingot: 'After about 100 mg of the finished water-washed chew, add 40 mL of 0.02 N sodium hydroxide in 30% methanol solution, and mash it in a crucible to dissolve and add water to the total. The volume is 50 mL and the force Q is mixed. Take lmL of this solution, add 90% ethanol and shake for 5 minutes, then add water to a total volume of 5 OmL and mix it, then carry out 1 〇 minute supersonic -44- 200816932 (42) wave treatment. The solution was centrifuged (300 rpm, 5 minutes), and the obtained supernatant was used as a sample solution. The sample solution was taken to quantify tocopherol acetate by HPLC. In the preparation of the sample solution, a part of the tocopherol acetate is replaced by tocopherol, and both tocopherol acetate and tocopherol are required to be quantified, and the amount of tocopherol acetate is determined from the sum of the two molar numbers. The chewing time was 0 minutes, -2 minutes, 5 minutes, 10 minutes, 20 minutes, 30 minutes, 45 minutes, and 6 minutes, respectively, and repeated three tests to quantify the remaining vinegar φ acid tocopherol in the chew. The residual rate (%) was obtained from the average of three times, and the dissolution rate (%) was calculated therefrom to determine the dissolution mode. The caffeine of the water-soluble substance is apparent from Fig. 1, about 80% after 10 minutes of chewing, and about 90% after 20 minutes. Conversely, the fat-soluble substance tocopherol acetate is about 40% after 10 minutes of chewing, about 60% after 20 minutes, about 70% after 30 minutes, and about 90% after 45 minutes, and more than 60% after 60 minutes. 90% was dissolved, but it was dissolved later than caffeine. Therefore, the functional component of the ingestible functional material by chewing can be clearly known. • Example 5 [Example 5] Chews the functional chew of the present invention and confirmed the result of complete digestion by the digestive tract after swallowing. The ingot was obtained by using the raw materials shown in [Table 6] to obtain a tablet having a spindle diameter of 13 mm and a spindle weight of 〇.6 g. ' Human digestion test was performed as follows. For 8 volunteers, the sputum took 1 to 2 tablets after the meal, 5 tablets per day, and 15 tablets on the 3rd. From the second day of taking the chew, to the third day after taking the drug, take the total amount of feces from the volunteers daily, observe and carefully distinguish whether the white block from the chew is excreted in the feces. . As a result, 8 of the voluntarily-45-200816932 (43) subjects did not find a white block from the chew that was digested. The functional chew of the present invention is confirmed to be digested in artificial gastric juice composed of trypsin derived from pig stomach mucosa and artificial intestinal juice composed of pancreatic enzyme derived from porcine pancreas. Therefore, it is clear that the functional chew is edible and can be completely digested in the digestive tract and does absorb the functional components of the functional material. [Table 6] Mixing amount of raw material name (g) Glycol protein (gumin) 48.0 Wheat gluten (vitamin gluten) 12.0 Polyphenols (catechin) 3.3 Functional materials (inulin, spore-like lactic acid) , Bifidobacterium) 25.0 Sweetener 3.0 Colorant (titanium oxide) 3.0 Perfume 3.0 Lubricant, flow promoting agent 2.7

實施例6 〔實施例6〕爲將混合醇溶蛋白類之麥膠蛋白、小麥 麩質之維生麩質、多酚類之兒茶素及功能性材料之具功能 性咀嚼物之第一例,確認其咀嚼時間與功能性材料之效果 。製造方法係將麥膠蛋白、維生麩質、兒茶素及木糖醇置 入攪拌造粒機中’攪拌同時依序加入乳香油、肉豆蔻粹取 物、艾草粹取物,接著將此混合物移往流動層造粒乾燥機 -46- 200816932 (44) ,以溶解後之甜味劑之α化澱粉之3 %水溶液進行噴霧, 再進行造粒、乾燥。下述〔表7〕爲流動層造粒條件。 〔表7〕 流動層造粒條件[Embodiment 6] [Example 6] is a first example of a functional chew which is mixed with a gliadin-like gliadin, a wheat gluten-based gluten, a polyphenol catechin, and a functional material. Confirm the effect of chewing time and functional materials. The manufacturing method is to put gliadin, vitamin gluten, catechin and xylitol into a stirring granulator. Stir and simultaneously add the mastic oil, the nutmeg extract, the wormwood extract, and then The mixture was transferred to a fluidized bed granulation dryer-46-200816932 (44), sprayed with a 3 % aqueous solution of the gelatinized starch, and then granulated and dried. The following [Table 7] is a fluidized bed granulation condition. [Table 7] Flowing layer granulation conditions

進氣溫度 9 0°C 排氣溫度 4 0°C 進氣風量 5m3/分鐘 噴霧液量 1 20mL/分鐘 噴霧空氣壓 1.2kg/ cm2 乾燥溫度 42〇CIntake air temperature 9 0°C Exhaust gas temperature 4 0°C Inlet air volume 5m3/min Spray volume 1 20mL/min Spray air pressure 1.2kg/ cm2 Drying temperature 42〇C

接著,於所得之造粒粉中加入以下述〔表8〕所示比 例之香料及潤滑劑,混合後將所得之打錠粉末以錠徑 13mm,1錠重量爲0.7g爲規格進行製錠。Then, the obtained granulated powder was added with a perfume and a lubricant in the proportions shown in the following [Table 8]. After mixing, the obtained tablet powder was tableted at a spindle diameter of 13 mm and a spindle weight of 0.7 g.

〔表8〕 原料名稱 混合量(g) 醇溶蛋白類(麥膠蛋白) 5 2 0 0.0 小麥麩質(維生麩質) 1 3 00.0 多酚類(兒茶素) 3 0 0.0 功能性材料(乳香油、肉豆蔻粹取物、艾草 粹取物、木糖醇) 2607.0 聚合劑(α化澱粉) 150.0 甜味劑 43.0 香料 250.0 潤滑劑 150.0 -47- 200816932 (45) 以1分鐘咀嚼7〇〜80次之速度阻嚼由上述配方所得之 具功能性咀嚼物後,其結果爲於15分鐘內’可保持具彈 性及聚合性之口感。 爲評價〔實施例6〕所得之具功能性咀嚼物其做爲功 能性之口腔內潔淨作用,使用口腔內氣體檢測器’測定咀 嚼1粒具功能性咀嚼物前後口腔之氣味時,於服用具功能 性咀嚼物前,呼出氣體中檢出6 0 p p m之氨氣,經咀嚼1 5 分鐘後,呼出氣體中檢出之氨氣爲1 〇PPm以下。可知〔實 施例6〕之具功能性咀嚼物,具有大幅減低口腔內細菌之 潔淨作用,明確得知其可將口腔內環境清淨化。 實施例7 〔實施例7〕爲將混合醇溶蛋白類之麥膠蛋白、多酚 類之葡萄籽花青素原及功能性材料之具功能性咀嚼物之第 二例’確認其咀嚼時間與功能性材料之效果。製造方法係 將如下述〔表9〕之原料混合粉末供給於乾式造粒機,得 平均粒子徑約500 # m,體積比容積i.8 mL/g之顆粒。接 著以錠徑1 5mm,1錠重量爲1 g爲規格進行製錠。 -48- 200816932 (46)[Table 8] Mixing amount of raw material name (g) Glycol protein (gumin) 5 2 0 0.0 Wheat gluten (vitamin gluten) 1 3 00.0 Polyphenols (catechin) 3 0 0.0 Functional materials ( Frankincense oil, nutmeg extract, wormwood extract, xylitol) 2607.0 Polymerizer (alphaated starch) 150.0 Sweetener 43.0 Spice 250.0 Lubricant 150.0 -47- 200816932 (45) Chew 7 minutes in 1 minute After a speed of ~80 times, the functional chew obtained from the above formula was chewed, and as a result, the mouthfeel which was elastic and polymerizable was maintained within 15 minutes. In order to evaluate the functional chews obtained in [Example 6] as a functional oral cleansing effect, using an intraoral gas detector' to measure the smell of the mouth before and after chewing a functional chew, Before the functional chew, 60 ppm of ammonia gas was detected in the exhaled gas. After chewing for 15 minutes, the ammonia gas detected in the exhaled gas was below 1 〇 PPm. It can be seen that the functional chew of [Example 6] has a significant effect of reducing the cleansing action of bacteria in the oral cavity, and it is clearly known that it can purify the oral environment. Example 7 [Example 7] is a second example of a functional chew which is mixed with a gliadin-type gliadin, a polyphenolic grape seed anthocyanin and a functional material to confirm the chewing time and The effect of functional materials. In the production method, the raw material mixed powder of the following [Table 9] was supplied to a dry granulator to obtain particles having an average particle diameter of about 500 #m and a volume specific volume of i.8 mL/g. Next, the ingot was made with a spindle diameter of 1 5 mm and a weight of 1 g. -48- 200816932 (46)

原料名稱 混合量(g) 醇溶蛋白類(麥膠蛋白) 2800.0 多酚類(葡萄籽花青素原) 150.0 功能性材料(白雲石(礦物質類)、綜合維他 命(維他命類)、焦磷酸鐵、酵母鋅、異黃 酮、菊糖) A A 1855.0 甜味齊|J 20.0 香料 125.0 潤滑劑 50.0 以1分鐘咀嚼70〜80次之速度咀嚼由上述配方所得之 具功能性咀嚼物後,其結果爲於7分鐘內,可保持具彈性 及聚合性之口感。 〔實施例7〕所得之具功能性咀嚼物因混合礦物質及 維他命’對普遍不足之中高齢者及希望減重的婦女具有效 果’同時因混合具有女性荷爾蒙般生理作用之異黃酮,可 Φ 適用於年輕族群至高齡者等大範圍年齡層的女性。 實施例8 〔實施例8〕爲將混合醇溶蛋白類之麥膠蛋白、小麥 麩質之維生麩質及功能性材料之具功能性咀嚼物之第三例 ,確認其咀嚼時間與功能性材料之效果。製造方法大致與 〔實施例6〕相同係將麥膠蛋白、維生麩質、銀杏葉粹取 物粉末、兒茶素、酵母鋅置入攪拌造粒機中,攪拌同時依 序加入DHA油及EPA油,接著將此混合物、乳鐵蛋白及 -49 - 200816932 (47) 菊糖移往流動層造粒乾燥機,以溶解後之甜味劑之^化殿 粉之3 %水溶液進行噴霧,再進行造粒、乾燥。 接著,於所得之造粒粉中加入以下述〔表10〕所示比 例之香料及潤滑劑,混合後將所得之打錠粉末以錠徑 13 mm,1錠重量爲〇.7g爲規格進行製錠。Mixing amount of raw material name (g) Glycol protein (gumin) 2800.0 Polyphenols (glucose anthocyanin) 150.0 Functional materials (dolomite (minerals), synthetic vitamins (vitamins), pyrophosphate Iron, yeast zinc, isoflavones, inulin) AA 1855.0 Sweetness | J 20.0 Perfume 125.0 Lubricant 50.0 After chewing the functional chew obtained from the above formula at a rate of 70 to 80 times in 1 minute, the result is It retains the elasticity and polymerity of the mouth in 7 minutes. [Example 7] The functional chews obtained by the mixed minerals and vitamins are effective for women who are generally devastated and who want to lose weight. At the same time, because of the mixing of isoflavones with female hormones, Φ Suitable for women from a wide range of age groups, from young to old. Example 8 [Example 8] is a third example of a functional chew which is mixed with prolamine protein, wheat gluten-based gluten and functional material, and the chewing time and functional material are confirmed. The effect. In the same manner as in [Example 6], the gliadin, the gluten, the ginkgo biloba powder, the catechin, and the yeast zinc are placed in a stirring granulator, and DHA oil and EPA are sequentially added while stirring. Oil, then the mixture, lactoferrin and -49 - 200816932 (47) inulin are transferred to a fluidized layer granulation dryer, and the 3% aqueous solution of the dissolved sweetener is sprayed, and then Granulation and drying. Next, the obtained granulated powder was added with a fragrance and a lubricant in the proportions shown in the following [Table 10], and the obtained tablet powder was mixed and prepared to have a spindle diameter of 13 mm and a weight of one spindle of 〇.7 g. ingot.

原料名稱 混合量(g) 醇溶蛋白類(麥膠蛋白) 5400.0 小麥麩質(維生麩質) 600.0 多酚類(兒茶素) 3 0 0.0 功能性材料(銀杏葉粹取物粉末、絲胺酸、 乳鐵蛋白、兒茶素、酵母鲜、DHA油、木 寡糖) 3335.0 聚合劑(α化澱粉) 120.0 甜味劑 45.0 香料 400.0 潤滑劑 100.0 以1分鐘咀嚼70〜80次之速度咀嚼由上述配方所得之 具功能性咀嚼物後,其結果爲於1 0分鐘內,可保持具彈 性及聚合性之口感。 〔實施例8〕所得之具功能性咀嚼物,因混合銀杏葉 粹取物、乳鐵蛋白、DHA等,具有抗癡呆作用、增強免疫 力作用、癌症預防作用、抗發炎作用、抗動脈硬化作用及 減低血脂作用,可適用於易罹患癡呆、癌症、關節炎、動 脈硬化等疾病之高齡者。 -50- 200816932 (48) 實施例9 〔實施例9〕爲將混合醇溶蛋白類之麥膠蛋白、小麥 麩質之維生麩質、多酚類之兒茶素及功能性材料之具功能 性咀嚼物之第四例,確認其咀嚼時間與功能性材料之效果 。製造方法大致與〔實施例6〕相同係將麥膠蛋白、維生 麩質、兒茶素置入攪拌造粒機中,以溶解後之甜味劑之α 化澱粉之3 %水溶液進行噴霧,再進行造粒、乾燥。接著 ,於所得之造粒粉中加入以下述〔表1 1〕所示比例之功能 性材料、甜味劑、香料及潤滑劑之混合粉末提供給乾式造 粒機’得平均粒子徑約3 5 0 // m,體積比容積2.0 mL/g之 顆粒。接著將所得之顆粒以淀徑1 3 m m,1錠重量爲0.6 5 g 進行打錠。Raw material name mixture (g) Prolamin (gumin) 5400.0 Wheat gluten (vitamin gluten) 600.0 Polyphenols (catechin) 3 0 0.0 Functional material (Ginkgo biloba extract powder, silk amine Acid, lactoferrin, catechin, yeast fresh, DHA oil, xylooligosaccharide) 3335.0 Polymerization agent (alpha starch) 120.0 Sweetener 45.0 Spice 400.0 Lubricant 100.0 Chew at 70 to 80 times in 1 minute by chewing After the functional chew obtained by the above formula, the result is that the mouthfeel with elasticity and polymerization can be maintained within 10 minutes. The functional chew obtained in [Example 8] has anti-dementia effect, immune-enhancing effect, cancer prevention effect, anti-inflammatory effect and anti-arteriosclerosis effect by mixing Ginkgo biloba extract, lactoferrin, DHA and the like. And reduce blood lipids, can be applied to elderly people who are prone to dementia, cancer, arthritis, arteriosclerosis and other diseases. -50- 200816932 (48) Example 9 [Example 9] is a functional mixture of prolamin, wheat gluten-based gluten, polyphenolic catechin, and functional materials. The fourth case of chews confirmed the effect of chewing time and functional materials. In the same manner as in [Example 6], the gliadin, the gluten, and the catechin are placed in a stirring granulator, and the 3% aqueous solution of the gelatinized starch of the sweetener is sprayed, and then sprayed. Granulation and drying. Next, a mixed powder of a functional material, a sweetener, a perfume, and a lubricant in a ratio shown in the following [Table 11] was added to the obtained granulated powder to provide a dry granulator with an average particle diameter of about 3 5 . 0 // m, particles with a volume ratio of 2.0 mL/g. The obtained pellets were then tableted at a diameter of 1 3 m and a weight of 0.65 g per spindle.

原料名稱 混合量(g) 醇溶蛋白類(麥膠蛋白) 6800.0 小麥麩質(維生麩質) 1200.0 多酚類(兒茶素) 3 00.0 功能性材料(蘋果多酚、香蕈粹取物、 2590.0 鐵葉綠素鈉、木糖醇) 聚合劑(α化澱粉) 105.0 甜味劑 2445.0 香料 3 5 0.0 潤滑劑 210.0 以1分鐘咀嚼70〜8〇次之速度咀嚼由上述配方所得之 具功能性阻嚼物後’其結果爲於1 0分鐘內,可保持具彈 -51 - 200816932 (49) 性及聚合性之口感。 〔實施例9〕所得之具功能性咀嚼物因混合蘋果多酚 、香蕈粹取物、鐵葉綠素鈉等消臭功能性材料,可適用爲 口臭及抑制糞便臭味等禮貌性用品。 < 實施例1 〇 〔實施例1 0〕爲將混合醇溶蛋白類之麥膠蛋白、小麥 Φ 麩質之維生麩質、多酚類之沒食子兒茶素沒食子酸脂及功 能性材料之具功能性咀嚼物之第五例,確認其咀嚼時間與 功能性材料之效果。製造方法大致與〔實施例7〕相同係 使用下述〔表1 2〕之原料將以乾式造粒機所製造之顆粒進 行打錠,得錠徑1 5 mm,1錠重量爲0 · 8 g,之錠劑。Raw material name mixture (g) Prolamin (gumin) 6800.0 Wheat gluten (vitamin gluten) 1200.0 Polyphenols (catechin) 3 00.0 Functional materials (apple polyphenols, citron extracts, 2590.0 Iron chlorophyll sodium, xylitol) Polymerization agent (alphaated starch) 105.0 Sweetener 2445.0 Perfume 3 5 0.0 Lubricant 210.0 Chew 70~8 times in 1 minute to chew the functional chews obtained from the above formula After the product, the result is that it can maintain the taste of the elastic-51 - 200816932 (49) and polymerization within 10 minutes. The functional chew obtained in [Example 9] can be applied to a peculiar product such as bad breath and suppressing stool odor by mixing deodorizing functional materials such as apple polyphenol, citron extract, and iron chlorophyll sodium. <Example 1 〇 [Example 10] is a mixture of prolamin-containing gliadin, wheat Φ gluten-based gluten, polyphenolic gallocatechin gallate and function The fifth example of a functional chew of a sexual material confirms the effect of chewing time and functional materials. In the same manner as in [Example 7], the pellets produced by the dry granulator were subjected to ingoting using the raw materials of the following [Table 12], and the ingot diameter was 15 mm, and the weight of one spindle was 0·8 g. , the lozenge.

原料名稱 混合量(g) 醇溶蛋白類(玉米蛋白) 560.0 小麥麩質(維生麩質) 1040.0 多酚類(沒食子兒茶素沒食子酸脂) 45.0 _ 功能性材料(蘋果多酚、香蕈粹取物、 鐵葉綠素鈉、木糖醇、果寡糖) 1031.0 甜味劑 12.0 香料 70.0 _ 潤滑劑 42.0 _ 以1分鐘咀嚼7 0〜8 0次之速度咀嚼由上述配方所得之 具功能性咀嚼物後,其結果爲於1 5分鐘內,可保持具彈 -52- 200816932 (50) 性及聚合性之口感。 〔實施例1 〇〕所得之具功能性咀嚼物與〔實施例9〕 相同,因混合蘋果多酚、香蕈粹取物、鐵葉綠素鈉等消臭 功能性材料,可適用爲口臭及抑制糞便臭味等禮貌性用品 實施例1 1 〔實施例1 1〕爲將混合醇溶蛋白類之麥膠蛋白、小麥 麩質之維生麩質、多酚類之法國海岸松樹皮萃取液及功能 性材料之具功能性咀嚼物之第六例,確認其咀嚼時間與功 能性材料之效果。製造方法係將下述〔表13〕之原料提供 給乾式造粒機,得平均粒子徑約3 5 0 # m,體積比容積1 · 9 m L / g之顆粒,再以錠徑1 5 m m,1錠重量爲0 · 8 5 g進行製 錠。 - 53- 200816932 (51) 〔表 13〕 ----SiL^稱 混合量(g) 醇溶蛋白類(麥膠番 2520.0 小麥麩質(維生麩暂) 280.0 多酸類(法國海岸松樹皮萃取物) 200.0 功能性材料(銀杏葉萃取物、輔酶Q_10、 _γ-氨基丁酸、蝦、長春花萃取物) 8 90.0 甜味劑 8 6 0.0 香料 2 0 0.0 潤滑劑 50.0Raw material name mixture (g) Prolamin (zein) 560.0 Wheat gluten (vitamin gluten) 1040.0 Polyphenols (gallocatechin gallate) 45.0 _ Functional material (apple polyphenols) , fragrant scent, iron chlorophyll sodium, xylitol, fructooligosaccharide) 1031.0 sweetener 12.0 fragrance 70.0 _ lubricant 42.0 _ chew 7 minutes to 0 0 times the speed of chewing from the above formula After the functional chew, the result is a boll-52-200816932 (50) and polymerizable mouthfeel within 15 minutes. [Comparative Example 1] The functional chew obtained in the same manner as in [Example 9] is suitable for bad breath and inhibiting feces by mixing deodorizing functional materials such as apple polyphenol, citron extract, and iron chlorophyll sodium. Politeness and other polite articles Example 1 1 [Example 1 1] is a mixture of prolamin-containing gliadin, wheat gluten-based gluten, polyphenolic French coastal pine bark extract and functional materials. The sixth example of a functional chew confirms the effect of chewing time and functional materials. The manufacturing method is to supply the raw materials of the following [Table 13] to a dry granulator to obtain particles having an average particle diameter of about 3 5 0 # m, a volume ratio of 1 · 9 m L / g, and an ingot diameter of 15 mm. The ingot was weighed at a weight of 0 · 8 5 g. - 53- 200816932 (51) [Table 13] ----SiL^mixed amount (g) gliadin (McGell 2520.0 Wheat gluten (vitamin bran) 280.0 Polyacid (French Coast Pine Bark Extract) 200.0 Functional material (Ginkgo biloba extract, coenzyme Q_10, _γ-aminobutyric acid, shrimp, vinca extract) 8 90.0 Sweetener 8 6 0.0 Spice 2 0 0.0 Lubricant 50.0

以1分鐘咀嚼70〜80次之速度咀嚼由上述配方所得之 具功能性咀嚼物後,其結果爲於7分鐘內,可保持具彈性 及聚合性之口感。 〔實施例1 1〕所得之具功能性咀嚼物因混合銀杏葉萃 取物、輔酶Q-10、γ-氨基丁酸、蝦青素、長春花萃取物, 可適用爲擔心癡呆之高齡者。 實施例1 2 〔實施例1 2〕爲將混合醇溶蛋白類之麥膠蛋白、小麥 麩質之維生麩質、多酚類之沒食子兒茶素沒食子酸脂及功 能性材料之具功能性咀嚼物之第七例,確認其咀嚼時間與 功能性材料之效果。製造方法大致係將下述〔表1 5〕之原 -54 - 200816932 (52) 料中之麥膠蛋白、維生麩質及沒食子兒茶素沒食子酸脂置 入流動層造粒乾燥機中,與〔實施例6〕大致相同地以α 化澱粉之3 %水溶液進行噴霧,再進行造粒、乾燥。於所 得之造粒粉中加入以〔表1 4〕所示比例之功能性材料、甜 *· 味劑、香料及潤滑劑之混合粉末提供給乾式造粒機’得平 /均粒子徑約3 00 // m,體積比容積2·2 mL/g之顆粒。接著 將所得之顆粒以錠徑1 5 mm,1錠重量爲0 · 8 §進行打錠。After chewing the functional chew obtained from the above formula at a rate of 70 to 80 times in 1 minute of chewing, the result was that the mouthfeel of elasticity and polymerization was maintained within 7 minutes. The functional chew obtained in [Example 1 1] can be applied to an elderly person who is worried about dementia by mixing Ginkgo biloba extract, coenzyme Q-10, γ-aminobutyric acid, astaxanthin, and periwinkle extract. Example 1 2 [Example 1 2] is a mixture of prolamin-containing gliadin, wheat gluten-based gluten, polyphenolic gallocatechin gallate, and functional material. The seventh example of a functional chew confirms the effect of chewing time and functional materials. The manufacturing method is generally carried out by placing the gliadin, the gluten-free gluten and the gallocatechin gallic acid in the original -54 - 200816932 (52) of the following [Table 15] into a flowing layer and granulating and drying. In the same manner as in [Example 6], the mixture was sprayed with a 3% aqueous solution of gelatinized starch, and granulated and dried. To the obtained granulated powder, a mixed powder of a functional material, a sweetener, a flavor, a lubricant and a lubricant in a ratio shown in [Table 14] is added to the dry granulator to obtain a flat/average particle diameter of about 3 00 // m, particles with a volume ratio of 2·2 mL/g. Next, the obtained pellets were tableted at a spindle diameter of 15 mm and a spindle weight of 0·8 §.

〔表 1 4〕 原料名稱 _ 混合量(g) 醇溶蛋白類(麥膠蛋白) 3 600.0 小麥麩質(維生麩質) 2400.0 多酚類(沒食子兒茶素沒食子酸脂) 150.0 功能性材料(咖啡因、藍莓、維他命B 1 、硫辛酸) 525.0 聚合劑(α化澱粉) 120.0 甜味劑 2760.0 香料 3 00.0 潤滑劑 150.0[Table 1 4] Raw material name _ Mixing amount (g) Glycol protein (gumin) 3 600.0 Wheat gluten (vitamin gluten) 2400.0 Polyphenols (gallocatechin gallate) 150.0 Functional materials (caffeine, blueberry, vitamin B 1 , lipoic acid) 525.0 Polymerizer (alphaated starch) 120.0 Sweetener 2760.0 Spice 3 00.0 Lubricant 150.0

以1分鐘咀嚼70〜80次之速度咀嚼由上述配方所得之 具功能性咀嚼物後,其結果爲於1 5分鐘內,可保持具彈 性及聚合性之口感。 〔實施例1 2〕所得之具功能性咀嚼物因混合咖啡因、 藍莓、維他命B 1,可適用爲駕駛防止瞌睡用品。 實施例1 3 -55- 200816932 (53) 〔實施例1 3〕爲將混合醇溶蛋白類之麥膠蛋白、小麥 麩質之維生麩質、多酚類之兒茶素及功能性材料之具功能 性咀嚼物之第八例’確認其咀嚼時間與功能性材料之效果 。製造方法係將下述〔表1 5〕之原料提供給乾式造粒機, 得平均粒子徑約5 0 〇从瓜,體積比容積1 · 8 mL/ g之顆粒, 再以錠徑15mm,1錠重量爲〇.9g進行製錠。After chewing the functional chew obtained from the above formula at a rate of 70 to 80 times in 1 minute of chewing, the result is that the elastic and polymeric mouthfeel can be maintained within 15 minutes. [Comparative Example 1 2] The functional chew obtained by mixing caffeine, blueberry, and vitamin B 1 can be applied as a driving prevention anti-snoring article. Example 1 3 -55- 200816932 (53) [Example 1 3] is a mixture of prolamin-containing gliadin, wheat gluten-based gluten, polyphenolic catechin and functional materials. The eighth example of a functional chew 'confirmed the effect of chewing time and functional materials. The manufacturing method is to supply the raw materials of the following [Table 15] to a dry granulator to obtain particles having an average particle diameter of about 50 Å from melon, a volume ratio of 1 8 mL/g, and an ingot diameter of 15 mm, 1 The ingot weight was 〇.9g for ingot making.

〔表 15〕 原料名稱 混合量(g) 醇溶蛋白類(麥膠蛋白) 2380.0 小麥麩質(維生麩質) 420.0 多酚類(兒茶素) 120.0 功能性材料(玻尿酸、蘋果多酚、輔酶Οι 〇 、 左旋 肉鹼、 異黃酮 、藤 黃果、 維他命 C、維他命Ε) 1380.0 甜味劑 1 100.0 香料 150.0 潤滑劑 75.0 以1分鐘咀嚼70〜80次之速度咀嚼由上述配方所得之 具功能性咀嚼物後,其結果爲於1 〇分鐘內,可保持具彈 性及聚合性之口感。 〔實施例1 3〕所得之具功能性咀嚼物因混合美白美膚 成分之玻尿酸、蘋果多酚、輔酶Q-10、維他命C等,及 抗肥胖成分之左旋肉鹼、藤黃果,以及具女性荷爾蒙生理 作用之異黃酮,可適用爲自年輕人至高齡者的廣大年齢層 之注意美容及肥胖的女性的補給品。 -56- 200816932 (54) 實施例1 4 〔實施例1 4〕爲將混合醇溶蛋白類之麥膠蛋白、小麥 麩質之維生麩質、多酚類之兒茶素及功能性材料之具功能 性咀嚼物之第九例,確認其咀嚼時間與功能性材料之效果 。製造方法係將下述〔表1 6〕之原料提供給乾式造粒機, 得平均粒子徑約500 μ m,體積比容積1 .7 mL/g之顆粒, 再以錠徑15mm,1錠重量爲〇.9g進行製錠。 〔表 16〕 原料名稱 混合量(g) 醇溶蛋白類(麥膠蛋白) 1000.0 小麥麩質(維生麩質) 1500.0 多酚類(兒茶素) 12 0.0 功能性材料(尼古丁、木糖醇) 95 0.0 甜味劑 1155.0 香料 2 0 0.0 潤滑劑 7 5.0 以1分鐘咀嚼7 0〜80次之速度咀嚼由上述配方所得之 具功能性咀嚼物後,其結果爲於1 5分鐘內,可保持具彈 性及聚合性之口感。 〔實施例14〕所得之具功能性咀嚼物因混合尼古丁’ 可適用爲戒煙輔助用之補給品。 實施例1 5 〔實施例1 5〕爲將混合醇溶蛋白類之麥膠蛋白、小麥 -57- 200816932 (55) 麩質之維生麩質、多酚類之兒茶素及功能性材料之具功能 性咀嚼物之第十例,確認其咀嚼時間與功能性材料之效果 。製造方法係將下述〔表1 7〕之原料提供給乾式造粒機’ 得平均粒子徑約500 # m,體積比容積1 .8 mL/g之顆粒, 再以錠徑15mm,1鏡重量爲〇.9g進行製錠。 〔表 17〕 原料名稱 混合量(g) 醇溶蛋白類(麥膠蛋白) 1040.0 小麥麩質(維生麩質) 260.0 多酚類(兒茶素) 52.0 功能性材料(蘋果多酚、香蕈粹取物、鐵 葉綠素鈉、木糖醇) 5 5 0.0 甜味劑 8.0 香料 70.0 潤滑劑 20.0 Φ 以1分鐘咀嚼70〜80次之速度咀嚼由上述配方所得之 具功能性咀嚼物0 · 8 g後,其結果爲於1 5分鐘內,可保持 ^ 具彈性及聚合性之口感。 〔實施例1 5〕所得之具功能性咀嚼物因與〔實施例9 着 〕同樣地混合蘋果多酚、香蕈粹取物、鐵葉綠素鈉等消臭 功能性材料’可適用爲抑制口臭及糞便臭之禮貌性用品。 實施例1 6 〔實施例16〕爲將混合醇溶蛋白類之麥膠蛋白、小麥 鞋質之維生變質、多酚類之兒茶素及功能性材料之具功能 -58 - 200816932 (56) 性咀嚼物之第十一例,確認其咀嚼時間與功能性材料之效 果。製造方法係將下述〔表1 8〕之原料提供給乾式造粒機 ,得平均粒子徑約3 5 0 " m,體積比容積1.8 mL/g之顆粒 ,再以錠徑1 5mm,1錠重量爲0.8g進行製錠。 〔表 18〕 原料名稱 混合量(g) 醇溶蛋白類(麥膠蛋白) 2400.0 小麥麩質(維生麩質) 1600.0 多酚類(兒茶素) 2 0 0.0 功能性材料(阿斯匹靈、咖啡因) 2900.0 甜味劑 450.0 酸味劑 150.0 香料 100.0 潤滑劑、流動促劑進 200.0 以1分鐘咀嚼70〜80次之速度咀嚼由上述配方所得之 Φ 具功能性咀嚼物後’其結果爲於1 0分鐘內分解而可吞食 〇 ^ 〔實施例1 6〕所得之具功能性咀嚼物因混合阿斯匹靈 及咖啡因,可適用爲無需水及可服用之解熱鎭痛劑。 實施例1 7 〔實施例1 7〕爲將混合醇溶蛋白類之麥膠蛋白、小麥 麩質之維生麩質、多酚類之兒茶素及功能性材料之具功能 性咀嚼物之第十二例’確認其咀嚼時間與功能性材料之效 -59- 200816932 (57) 果。製造方法係將〔表1 9〕中之麥膠蛋白、維生麩質置入 攪拌造粒機中,再加入乳香油。接著,於該混合物中加入 兒茶素、乳香油以外之功能性材料、甜味劑及促進流動劑 之一半量混合後,將該混合粉末提供給乾式造粒機。所得 之造粒粉末中再加入已混合一半量之結晶纖維素、香料及 促進流動劑之混合粉末,而可得錠徑1 5mm,1錠重量爲 〇.8g之錠劑。 如同本實施例,使用做爲功能性材料之如乳香油之油 狀物,且以乾式造粒粉末進行製錠時,因成形性低下,混 合結晶纖維素等成形輔助劑時可有助於製錠。但成形輔助 劑之混合量以約1 0 %爲佳,超過1 5 %時咀嚼物之伸展性 會變低,原本柔軟地嚼感會變差而不佳。 〔表 1 9〕 原料名稱 混合量(g) 醇溶蛋白類(麥膠蛋白) 8 00.0 小麥麩質(維生麩質) 200.0 多酚類(兒茶素) 4 0.0 功能性材料(乳香油、甘草粹取物粉末、 艾草粹取物粉末、木糖醇、菊糖) 270.0 成形輔助劑(結晶纖維素) 16 0.0 一 甜味劑 50.0 香料 5 0.0 促進流動劑 30.0__ 以1分鐘咀嚼70〜8 0次之速度咀嚼由上述配方所得之 具功能性咀嚼物後,其結果爲於15分鐘內,可保持具彈 -60- 200816932 (58) 性及聚合性之口感。 〔實施例17〕所得之具功能性咀嚼物因與〔實施例6 〕相同,混合了乳香油而可適用爲口腔內淨化劑。 實施例1 8 〔實施例1 8〕爲將混合醇溶蛋白類之麥膠蛋白、小麥 麩質之維生麩質、多酚類之兒茶素、蛋白質分解酵素劑之 來自枯草桿菌之中性蛋白酶製劑及功能性材料之具功能性 咀嚼物之第十三例,確認蛋白質分解酵素劑與功能性材料 之效果。製造方法係將下述〔表20〕之原料混合粉末提供 給乾式造粒機,得平均粒子徑約3 5 0 // m,體積比容積1 . 9 mL/g之顆粒,再以錠徑15mm,1錠重量爲0.9g進行製錠 〔表 20〕 原料名稱. 混合量(g) 醇溶蛋白類(麥膠蛋白) ---—. 960.0 小麥麩質(維生麩質) ----- 240.0 多酚類(兒茶素) 48.0 來自枯草桿菌之中性蛋白酶製劑(蛋白 質分解酵素劑) 12.0 功能性材料(蘋果多酚、香覃粹取物、 鐵葉綠素鈉、木糖醇) ----— 642.0 甜味劑 — 8.0 香料 7 0.0 潤滑劑 2 0.0 -61 - 200816932 (59) 以1分鐘咀嚼70〜80次之速度咀嚼由上述配方所得之 具功能性咀嚼物後,其結果爲於5分鐘內即分散而可呑食 〇 〔實施例1 8〕所得之具功能性咀嚼物因與〔實施例9 〕同樣地混合蘋果多酚、香蕈粹取物、鐵葉綠素鈉等消臭 功能性材料,可適用爲抑制口臭及糞便臭之禮貌性用品。 實施例1 9 〔實施例1 9〕爲將混合醇溶蛋白類之麥膠蛋白、小麥 麩質之維生麩質、多酚類之兒茶素、助崩解劑之明膠及功 能性材料之具功能性咀嚼物之第十四例,確認助崩解劑與 功能性材料之效果。製造方法係將下述〔表2 1〕之原料混 合粉末提供給乾式造粒機,得平均粒子徑約3 00 // m,體 積比容積2.0 mL/g之顆粒,再以錠徑13mm,1錠重量爲 〇 . 6 g進行製錠。 〔表 21〕 原料名稱 混合量(g) 醇溶蛋白類(麥膠蛋白) 2880.0 小麥麩質(維生麩質) 7 2 0.0 多酚類(兒茶素) 200.0 助崩解劑(明膠) 1200.0 功能性材料(有孢子性乳酸菌、比菲德氏 菌、菊糖) 48 0.0 甜味劑 180.0 香料 180.0 潤滑劑、促進流動劑 16 0.0 -62- 200816932 (60) 以1分鐘咀嚼70〜80次之速度咀嚼由上述配方所得之 具功能性电嚼物後,其結果爲於7分鐘內即分散而可呑食 〇 〔實施例1 9〕所得之具功能性咀嚼物因混合有孢子性 乳酸菌與比菲德氏菌等乳酸菌,可適用爲整腸劑。 實施例20 〔實施例20〕係具功能性咀嚼物使用方法之第一例, 確認其使用方法之效果。係使用與〔實施例1 5〕相同之具 功能性咀嚼物,於再進而追加咀嚼之具功能性咀嚼物中, 使用於〔實施例1 8〕中混合蛋白質分解酵素劑者。 其方法係以5分鐘咀嚼1錠〔實施例1 5〕之錠劑,待 其變爲具彈性及集合性之橡膠塊狀之狀態時,再進而追加 咀嚼1錠〔實施例1 8〕所示之具功能性咀嚼物。其結果, 〔實施例1 8〕所示之具功能性咀嚼物因蛋白質分解酵素劑 作用,於5分鐘後即分散而可吞食。 實施例21 〔實施例2 1〕係具功能性咀嚼物使用方法之第二例, 確認其使用方法之效果。係使用與〔實施例1 5〕相同之具 功能性咀嚼物,再進而追加咀嚼之固狀咀嚼物係使用如下 所述之製造方法所製造者。 固狀咀嚼物之製造方法將下述〔表22〕之原料混合粉 末提供給乾式造粒機’得平均粒子徑約5 00 μ m,體積比 -63- 200816932 (61) 容積2. G mL/g之顆粒。再將該顆粒以錠徑15111111,1錠重 量爲〇.9g進行製錠。 〔表 22〕 ―― 原料名稱 混合量(g) 醇溶蛋白類(麥膠蛋白) 1800.0 小麥麩質(維生麩質) 200.0 木糖醇 8 8 5.0 甜味劑 10.0 香料 7 5.0 潤滑劑 30.0[Table 15] Mixing amount of raw material name (g) Glycol protein (gumin) 2380.0 Wheat gluten (vitamin gluten) 420.0 Polyphenols (catechin) 120.0 Functional materials (hyaluronic acid, apple polyphenols, coenzyme Οι 〇, L-carnitine, isoflavones, Garcinia Cambogia, Vitamin C, Vitamin Ε) 1380.0 Sweetener 1 100.0 Perfume 150.0 Lubricant 75.0 Chew 70-80 times in 1 minute to chew the functionality obtained from the above formula After the chew, the result is an elastic and polymeric mouthfeel in 1 minute. [Example 1 3] The functional chew obtained by mixing the whitening skin component with hyaluronic acid, apple polyphenol, coenzyme Q-10, vitamin C, etc., and the anti-obesity component of L-carnitine, Garcinia Cambogia, and The isoflavones of the physiological role of female hormones can be applied to the supply of beauty and obese women from the young age to the elderly. -56- 200816932 (54) Example 1 4 [Example 14] is a mixture of prolamin-containing gliadin, wheat gluten-based gluten, polyphenolic catechin and functional materials. The ninth example of a functional chew confirms the effect of chewing time and functional materials. The manufacturing method is to supply the raw materials of the following [Table 16] to a dry granulator to obtain particles having an average particle diameter of about 500 μm and a volume specific volume of 1.7 mL/g, and an ingot diameter of 15 mm, 1 spindle weight. The ingot was made for 9.9g. [Table 16] Mixing amount of raw material name (g) Glycol protein (gumin) 1000.0 Wheat gluten (vitamin gluten) 1500.0 Polyphenols (catechin) 12 0.0 Functional material (nicotine, xylitol) 95 0.0 Sweetener 1155.0 Perfume 2 0 0.0 Lubricant 7 5.0 After chewing the functional chew obtained from the above formula at a rate of 70 to 80 times in 1 minute, the result is that it can be retained within 15 minutes. Elastic and polymeric taste. [Comparative Example 14] The functional chew obtained by mixing nicotine can be applied as a supplement for smoking cessation assistance. Example 1 5 [Example 15] is a mixture of prolamin-containing gliadin, wheat-57-200816932 (55) gluten-based gluten, polyphenolic catechin and functional materials. The tenth example of a functional chew confirms the effect of chewing time and functional materials. The manufacturing method is to supply the raw materials of the following [Table 17] to the dry granulator to obtain particles having an average particle diameter of about 500 # m, a volume ratio of 1.8 mL/g, and a spindle diameter of 15 mm, 1 mirror weight. The ingot was made for 9.9g. [Table 17] Mixing amount of raw material name (g) Glycol protein (gumin) 1040.0 Wheat gluten (vitamin gluten) 260.0 Polyphenols (catechin) 52.0 Functional material (apple polyphenol, fragrant scent) Take, sodium chlorophyll sodium, xylitol) 5 5 0.0 Sweetener 8.0 Perfume 70.0 Lubricant 20.0 Φ After chewing 70~80 times in 1 minute, chew the functional chew obtained from the above formula 0 · 8 g As a result, the texture and elasticity of the polymer can be maintained within 15 minutes. [Comparative Example 15] A functional chew obtained by mixing the apple polyphenol, the citron extract, and the deodorizing functional material such as iron chlorophyll sodium as in [Example 9] can be applied to suppress bad breath and Polite smell of feces. Example 1 6 [Example 16] is a function of mixing gliadin mixed with gliadin, wheat shoe quality, polyphenolic catechin and functional material - 58 - 200816932 (56) The eleventh example of a chew is to confirm the effect of chewing time and functional materials. The manufacturing method is to supply the raw materials of the following [Table 18] to a dry granulator to obtain particles having an average particle diameter of about 3 5 0 " m, a volume ratio of 1.8 mL/g, and an ingot diameter of 15 mm, 1 The ingot was weighed at 0.8 g. [Table 18] Mixing amount of raw material name (g) Glycol protein (gumin) 2400.0 Wheat gluten (vitamin gluten) 1600.0 Polyphenols (catechin) 2 0 0.0 Functional material (aspirin, Caffeine) 2900.0 Sweetener 450.0 Sour Agent 150.0 Perfume 100.0 Lubricant, Flow Promoter Into 200.0 After chewing 70~80 times in 1 minute, chew the Φ functional chew obtained from the above formula, the result is 1 It can be swallowed in 0 minutes and can be swallowed. The functional chews obtained in [Example 1 6] can be applied as an antipyretic and analgesic agent which does not require water and can be taken by mixing aspirin and caffeine. Example 1 7 [Example 17] is a tenth of a functional chew which is mixed with prolamine protein, wheat gluten-based gluten, polyphenol catechin and functional material. Two cases 'confirmed the effect of chewing time and functional materials-59- 200816932 (57). The manufacturing method is to put the gliadin and the gluten in [Table 19] into a stirring granulator, and then add the mastic oil. Next, after the mixture is mixed with a functional material other than catechin and mastic oil, a sweetener, and a flow-promoting agent, the mixed powder is supplied to a dry granulator. To the obtained granulated powder, a mixed powder of a half amount of the crystalline cellulose, the flavoring agent and the flow promoting agent was further added to obtain a tablet having a spindle diameter of 15 mm and a weight of 1 ingot of 〇.8 g. As in the present embodiment, when an oily material such as a mastic oil is used as a functional material, and the ingot is formed by a dry granulated powder, it may contribute to the formation of a molding aid such as a crystalline cellulose when the formability is lowered. ingot. However, the mixing amount of the forming aid is preferably about 10%, and when it exceeds 15%, the stretchability of the chew is lowered, and the soft chewy feeling is poor. [Table 1 9] Mixing amount of raw material name (g) Glycol protein (gumin) 8 00.0 Wheat gluten (vitamin gluten) 200.0 Polyphenols (catechin) 4 0.0 Functional material (mastic oil, licorice) Extract powder, wormwood powder, xylitol, inulin) 270.0 Forming aid (crystalline cellulose) 16 0.0 One sweetener 50.0 Perfume 5 0.0 Promote flow agent 30.0__ Chew 70~8 in 1 minute At a speed of 0 times, the functional chews obtained from the above formula were chewed, and as a result, the mouthfeel of -60-200816932 (58) and polymerizability was maintained within 15 minutes. The functional chew obtained in [Example 17] is the same as [Example 6], and is mixed with mastic oil to be used as an oral cavity purifying agent. Example 1 8 [Example 18] is a mixture of prolamin-containing gliadin, wheat gluten-based gluten, polyphenolic catechin, and proteolytic enzyme from Bacillus subtilis. The thirteenth example of functional chews of preparations and functional materials confirms the effects of protein-decomposing enzymes and functional materials. The manufacturing method is to supply the raw material mixed powder of the following [Table 20] to a dry granulator to obtain particles having an average particle diameter of about 305 // m, a volume ratio of 1.9 mL/g, and a spindle diameter of 15 mm. , 1 spindle weight of 0.9g for tableting [Table 20] Raw material name. Mixing amount (g) Prolamin (gumin) ---.. 960.0 Wheat gluten (vitamin gluten) ----- 240.0 Polyphenols (catechins) 48.0 From Bacillus subtilis neutral protease preparation (proteolytic enzyme) 12.0 Functional materials (apple polyphenols, citron extract, iron chlorophyll sodium, xylitol) --- - 642.0 Sweetener - 8.0 Perfume 7 0.0 Lubricant 2 0.0 -61 - 200816932 (59) After chewing the functional chew from the above formula at a rate of 70 to 80 times in 1 minute, the result is 5 A functional chew obtained by dispersing the food in a minute (Example 18) is mixed with a deodorizing functional material such as apple polyphenol, citron extract or iron chlorophyll sodium as in [Example 9]. It can be used as a courtesy product to suppress bad breath and fecal odor. Example 1 9 [Example 19] is a mixture of prolamin-containing gliadin, wheat gluten-based gluten, polyphenolic catechin, disintegrating gelatin, and functional materials. The fourteenth example of a functional chew confirms the effect of the disintegrating agent and the functional material. The manufacturing method is to supply the raw material mixed powder of the following [Table 2 1] to a dry granulator to obtain particles having an average particle diameter of about 300 // m and a volume ratio of 2.0 mL/g, and then a spindle diameter of 13 mm, 1 The ingot weight is 〇. 6 g for ingot making. [Table 21] Mixing amount of raw material name (g) Glycol protein (gumin) 2880.0 Wheat gluten (vitamin gluten) 7 2 0.0 Polyphenols (catechin) 200.0 Disintegrant (gelatin) 1200.0 Function Sexual material (spore lactic acid bacteria, Bifidobacterium, inulin) 48 0.0 Sweetener 180.0 Perfume 180.0 Lubricant, flow promoting agent 16 0.0 -62- 200816932 (60) Chew 70~80 times in 1 minute After chewing the functional chewable obtained from the above formula, the result is that the functional chew obtained by dispersing in 7 minutes can be used for feeding the cockroach [Example 19] due to the mixing of spore-forming lactic acid bacteria and Bieder Lactic acid bacteria such as bacteria can be used as an enteral preparation. Example 20 [Example 20] A first example of a method for using a functional chew was used, and the effect of the method of use was confirmed. A functional chew which is the same as [Example 15] is used, and a functional chew which is further chewed is used, and the proteolytic enzyme is mixed in [Example 18]. In the method, one tablet of the tablet (Example 15) is chewed in 5 minutes, and when it is in a state of being elastic and aggregated in the form of a rubber block, one additional chew is further added (Example 18). Functional chews. As a result, the functional chews shown in [Example 18] were dispersed by the action of the proteolytic enzyme agent after 5 minutes, and were swallowed. Example 21 [Example 2 1] A second example of a method for using a functional chew was examined, and the effect of the method of use was confirmed. A functional chew similar to that of [Example 15] was used, and further a chewable solid chew was produced by the following manufacturing method. The manufacturing method of the solid chew is supplied to the dry granulator by the raw material mixed powder of the following [Table 22] to have an average particle diameter of about 500 μm, a volume ratio of -63 to 200816932 (61), and a volume of 2. G mL/ G particles. Further, the pellet was tableted at a spindle diameter of 15111111 and a weight of one spindle of 〇.9g. [Table 22] - Raw material name Mixing amount (g) Glycol protein (gumin) 1800.0 Wheat gluten (vitamin gluten) 200.0 Xylitol 8 8 5.0 Sweetener 10.0 Perfume 7 5.0 Lubricant 30.0

根據上述方法,以5分鐘咀嚼1錠〔實施例15〕之錠 劑,待其變爲具彈性及集合性之橡膠塊狀之狀態時,再進 而追加咀嚼1錠〔實施例21〕所示之固狀咀嚼物。其結果 ,於2分鐘後即分散而可呑食。且僅咀嚼固狀咀嚼物時, 因未混合多酚類而可於2分鐘前即分散。 實施例22 〔實施例22〕係具功能性咀嚼物使用方法之第三例, 確認其使用方法之效果。係使用與〔實施例1 5〕相同之具 功能性咀嚼物,再進而追加咀嚼之速崩解錠係使用由 300mg之三仙膠、維他命B1、微結晶纖維素、lacuchtose 及潤滑劑所構成之1錠70 Omg之錠劑。 咀嚼1錠〔實施例1 5〕之錠劑,待其變爲具彈性及集 合性之橡膠塊狀之狀態時,再進而追加咀嚼1錠〔實施例 -64- 200816932 (62) 22〕所示之速崩解錠。其結果,於2分鐘後即分散而可吞 食。 本發明之具功能性之咀嚼物及其製造方法與使用方法 ,未僅限定於上述之型態例,若備有藉具可食性的具功能 性材料而爲有效成分之其他材料亦可,且於不脫離本發明 要旨之範圍內加入各種變更者亦當然可行。 本發明係之具功能性之咀嚼物,較軟糖具有更長、且 各種時間長度之咀嚼時間,同時可不仰賴這些物質之水溶 性等性質而攝取充分的功能性材料,且本發明之製造方法 可提供合適之具功能性之咀嚼物,以及本發明之具功能性 之咀嚼物其使用方法爲可調整咀嚼時間。 【圖式簡單說明】 〔圖1〕實施本發明方式之實施例4之結果圖。 -65-According to the above method, one tablet of the tablet [Example 15] is chewed in 5 minutes, and when it is in a state of being elastic and aggregated in the form of a rubber block, one additional tablet is added (Example 21). Solid chews. As a result, it was dispersed after 2 minutes and was foraging. When only the solid chew is chewed, it can be dispersed 2 minutes before the polyphenols are not mixed. [Example 22] [Example 22] A third example of a method for using a functional chew was examined, and the effect of the method of use was confirmed. Using the same functional chew as in [Example 15], and further adding a chewing fast disintegrating tablet using 300 mg of Sanxian gum, vitamin B1, microcrystalline cellulose, lacuchtose and a lubricant. 1 tablet 70 Omg tablet. Chew one tablet of the tablet [Example 15], and when it is in a state of being elastic and aggregated in the form of a rubber block, one additional chew is further added (Example-64-200816932 (62) 22] Speed disintegration ingots. As a result, it was dispersed after 2 minutes and was swallowed. The functional chew of the present invention, the method for producing the same, and the method of using the same are not limited to the above-described types of examples, and other materials having an active ingredient by using a functional material having an edible property may be used, and It is of course also possible to add various modifications without departing from the gist of the invention. The functional chew of the present invention has a longer chewing time than the soft candy and various lengths of time, and can take in sufficient functional materials without depending on the water solubility and the like of these substances, and the manufacturing method of the present invention A suitable functional chew can be provided, as well as a functional chew of the present invention which can be used in an adjustable chewing time. BRIEF DESCRIPTION OF THE DRAWINGS [Fig. 1] A graph showing the results of Example 4 of the mode of the present invention. -65-

Claims (1)

200816932 (1) 十、申請專利範圍 1. 一種具功能性之咀嚼物,其係以醇溶蛋白類、小麥 麩質及功能性材料爲原料將其錠劑化或顆粒化,於咀嚼時 含唾液後產生彈性與伸展性,較具可食性之軟糖更加延長 : 其咀嚼時間而構成。 , 2.如申請專利範圍第1項之具功能性之咀嚼物,其中 醇溶蛋白類與小麥麩質之比例係以重量比爲8 : 2〜2 ·· 8所 • 構成。 3 · —種具功能性之咀嚼物,其係以醇溶蛋白類、多酉分 類及功能性材料爲原料將其錠劑化或顆粒化,於咀嚼時含 唾液後產生彈性與伸展性,較具可食性之軟糖更加延長其 咀嚼時間,同時藉由多酚類提升其彈性及伸展性而構成。 4 · 一種具功能性之咀嚼物,其係以醇溶蛋白類、小麥 麩質、多酚類及功能性材料爲原料將其錠劑化或顆粒化, 於咀嚼時含唾液後產生彈性與伸展性,較具可食性之軟糖 φ 更加延長其咀嚼時間,同時藉由多酚類.提升其彈性及伸展 性而構成。 5 .如申請專利範圍第4項之具功能性之咀嚼物,其中 A 醇溶蛋白類與小麥麩質之比例係以重量比爲9.9 : 0.1〜2 : - 8所構成。 6. 如申請專利範圍第3或4項之具功能性之咀嚼物, 其中係由相對於醇溶蛋白類與小麥麩質合計量混合入1〜20 %之多酚類所組成。 7. 如申請專利範圍第1、'3或4項之具功能性之咀嚼 -66- 200816932 (2) 物,其中醇溶蛋白類係由小麥的麥膠蛋白、玉米的玉米蛋 白、大麥的大麥蛋白中所選出之至少一種所組成。 8. 如申請專利範圍第1、3或4項之具功能性之咀嚼 物,其中功能性材料係自包含茶葉兒茶素、沒食子兒茶素 :沒食子酸脂、葡萄籽花青素原、法國海岸松樹皮萃取物之 r 多酚類、芝麻木聚糖類、來自紅球藻之還原蝦紅素、γ-氨 基丁酸、降壓胜肽、木糖醇、乳香萃取物、蜂膠、海蘿聚 φ 糖、肉萱蔻及艾草之藥材萃取物類、蘑菇、桑黃及猴頭菇 之菇類萃取物類、岩藻依聚糖、經加熱處理之乳酸菌菌體 粉末、乳鐵蛋白、異黃酮、銀杏葉萃诹物、小長舂花萃取 物、磷脂醯絲胺酸、花生油酸、來自魚類的ΕΡ Α及DH A 高度不飽和脂肪酸、辣椒粉末、烯酮素、辣椒素酯、輔酶 Q -1 0、硫辛酸、肉鹼鹽酸鹽、柑橘萃取物、五層龍萃取物 、武靴葉萃取物、四季豆萃取物、桑葉萃取物、維他命類 、黃綠色蔬菜萃取物類、蜂王漿、鈣化合物•鎂化合物· # 酵母鋅、鐵劑之礦物質類、滋養強壯用藥材萃取物類、腦 醯胺、玻尿酸、半胱胺酸、胱胺酸、香覃萃取物、銅葉綠 . 素鈉、鐵葉綠素鈉、乳酸菌類、菊糖、果寡糖、半乳糖寡 糖、木寡糖、尼古丁、咖啡因、茶胺酸中選用至少一種以 ’ 上而組成。 9. 如申請專利範圍第1、3或4項之具功能性之咀嚼 物,其中功能性材料係自包含蘋果花青素原、果露萃取物 、藍莓萃取物之多酚類、來自黑豆的青色素配糖體、薑黃 素、四氫薑黃素、甘蔗原素、二十八烷醇、膠原蛋白、植 -67- 200816932 (3) 酸、阿斯匹靈、乙醯胺酚、dl-馬來酸氯菲安明 可待因、dl-鹽酸甲基麻黃鹼、檸檬酸替培匹啶 酶、美遠志流浸膏、咖啡因、烯丙基異丙基乙 烷基氯化砒啶、鹽酸氯己啶、甲酚磺酸鉀、山 :草、1 -薄荷醇、葜磺酸鈉中選用至少一種以上Ϊ , 1 0.如申請專利範圍第3或4項之具功能 ,其中多酚類係自兒茶素類、沒食子兒茶素沒 0 花青素原、花青素、黃酮醇、異黃酮、芝麻素 薑黃素、柿單寧中選用至少一種而組成。 1 1 .如申請專利範圍第1、. 3或4項之具功 物,其係混合1〜4 0 %之蛋白質分解酵素劑而組 1 2 .如申請專利範圍第1 1項之具功能性之 中蛋白質分解酵素劑係由選自絲狀真菌、細菌 放射菌及植物來源之蛋白質分解酵素而組成。 1 3 .如申請專利範圍第1、3或4項之具功 φ 物,其係混合5〜40%之助崩解劑而組成。 14.如申請專利範圍第13項之具功能性之 中助崩解劑係由選自明膠、酪蛋白鈉、酪蛋白 — 白之蛋白質,或角叉菜膠、三仙膠、結冷膠、 , 菜、羥甲基纖維素鈉、羥甲基纖維素鈣、海藻 類,聚乙烯聚咯烷酮、脂肪酸甘油酯而組成。 1 5 . —種具功能性之咀嚼物之製造方法’ 蛋白類、小麥麩質及功能性材料爲原料將其錠 化而成。 、磷酸二氫 、氯化溶菌 醯脲、十六 櫻樹皮、甘 而組成。 性之咀嚼物 食子酸脂、 、槲黃素、 能性之咀嚼 成。 咀嚼物,其 、擔子菌、 能性之咀嚼 咀嚼物,其 鈣及膠原蛋 黃耆膠、洋 酸鈉之多醣 其係以醇溶 劑化或顆粒 -68- 200816932 (4) 16·如申請專利範圍第15項之具功能性之咀嚼物之製 造方法’其中醇溶蛋白類與小麥麩質之比例係重量比爲8 :2〜2 : 8所構成。 1 7 . —種具功能性之咀嚼物之製造方法,其係將醇溶 ; 蛋白類、多酚類及功能性材料錠劑化或顆粒化而成。 , 1 8 · —種具功能性之咀嚼物之製造方法,其係將醇溶 蛋白類、小麥麩質、多酚類及功能性材料錠劑化或顆粒化 ^ 而成。 1 9·如申請專利範圍第1 8項之具功能性之咀嚼物之製 造方法,其中醇溶蛋白類與小麥麩質之比例係重量比爲 9·9 : 0.1〜2 : 8所構成。 20·如申請專利範圍第17或18項之具功能性之咀嚼 物之製造方法,其係由相對於醇溶蛋白類與小麥麩質合計 量混合入1〜20%之多酚類所組成。 2 1 ·如申請專利範圍第1 5、1 7或1 8項之具功能性之 φ 咀嚼物之製造方法,其係由混合1〜4 0%之蛋白質分解酵素 劑而組成。 梦 22·如申請專利範圍第15、17或18項之具功能性之 咀嚼物之製造方法,其係由混合5〜40%之助崩解劑而組成 、 〇 . 2 3·—種具功能性之咀嚼物之使用方法,其係咀嚼如 申請專利範圍第1〜8項或第1 0項中任一項之具功能性之 咀嚼物後,再追加咀嚼如申請專利範圍第1 1項之具功能 性之咀嚼物而組成。 -69- 200816932 (5) 24. —種具功能性之咀嚼物之使用方法,其係咀嚼如 申請專利範圍第9項之具功能性之咀嚼物後,再追加咀嚼 如申請專利範圍第1 1項之具功能性之咀嚼物而組成。 25 · —種具功能性之咀嚼物之使用方法,其係咀嚼如 :申請專利範圍棄〗〜8項或第i 〇項中任一項之具功能性之 . 咀嚼物,咀嚼時間爲1 0分鐘以上,再重新追加咀嚼咀嚼 時間爲2分鐘以下之固狀咀嚼物或具功能性之咀嚼物而組 _ 成。 2 6. —種具功能性之咀嚼物之使用方法,其係咀嚼如 申請專利範圍第9項之具功能性之咀嚼物,咀嚼時間爲1 0 分鐘以上,再重新追加咀嚼咀嚼時間爲2分鐘以下之固狀 咀嚼物或具功能性之咀嚼物而組成。 27·如申請專利範圍第25或26項之具功能性之咀嚼 物之使用方法,其中固狀咀嚼物係醇溶蛋白類或醇溶蛋白 類與小麥麩質比例爲重量比9.9 : 0.1〜8.1 : 1.9。 φ 2 8 · —種具功能性之咀嚼物之使用方法,其係咀嚼如 申請專利範圍第1〜8項或第1 0項中任一項之具功能性之 , 咀嚼物,咀嚼時間爲1 0分鐘以上,再追加咀嚼有機酸之 錠劑而組成。 、 29.—種具功能性之咀嚼物之使用方法,其係咀嚼如 申請專利範圍第9項之具功能性之咀嚼物,咀嚼時間爲1 0 分鐘以上,再追加咀嚼有機酸之錠劑而組成。 30.如申請專利範圍第28或29項之具功能性之咀嚼 物之使用方法,其中有機酸係自檸檬酸、蘋果酸、酒石酸 -70- 200816932 (6) 、琥珀酸、葡萄糖酸、乳酸、醋酸中選用至少一種而組成 〇 3 1 · —種具功能性之咀嚼物之使用方法,其係咀嚼如 申請專利範圍第1〜8項或第10項中任一項之具功能性之 : 咀嚼物,咀嚼時間爲10分鐘以上,再重新追加咀嚼速崩 ^ 解錠而組成。 32.—種具功能性之咀嚼物之使用方法,其係咀嚼如 φ 申請專利範圍第9項之具功能性之咀嚼物,咀嚼時間爲1 0 分鐘以上,再重新追加咀嚼速崩解錠而組成。 3 3 .如申請專利範圍第3 1或3 2項之具功能性之咀嚼 物之使用方法,其中速崩解錠係含有選自檸檬酸、蘋果酸 、酒石酸、琥珀酸、葡萄糖酸、乳酸、醋酸、抗壞血酸之 有機酸,明膠、酪蛋白鈉、膠原蛋白之蛋白質,角叉菜膠 、三仙膠、結冷膠、黃耆膠、洋菜、羥甲基纖維素鈉、羥 甲基纖維素鈣、海藻酸鈉之多醣類,多麩醯胺酸、精胺酸 m 、可可粉、乳酪粉中至少一種而組成。 -71 -200816932 (1) X. Patent application scope 1. A functional chew which is tableted or granulated with gliadin, wheat gluten and functional materials as raw materials, and contains saliva when chewed. It produces elasticity and stretchability, and is more prolonged than the edible soft candy: it consists of chewing time. 2. A functional chew according to item 1 of the patent application, wherein the ratio of prolamin to wheat gluten is 8:2~2 ··8 in weight ratio. 3 · A functional chew that is tableted or granulated with prolamin, polysaccharides and functional materials, and produces elasticity and stretch after saliva. The edible soft candy further prolongs its chewing time while being composed of polyphenols to enhance its elasticity and stretchability. 4 · A functional chew that is tableted or granulated with prolamin, wheat gluten, polyphenols and functional materials, and elastic and stretched after saliva containing chewing Sexuality, the more edible soft candy φ further prolongs its chewing time, and is composed of polyphenols to enhance its elasticity and stretchability. 5. A functional chew according to item 4 of the patent application, wherein the ratio of a prolamine to wheat gluten is 9.9: 0.1 to 2: - 8 by weight. 6. A functional chew according to claim 3 or 4, wherein the chewing gum is composed of 1 to 20% polyphenols mixed with gliadin and wheat gluten. 7. For the functional chewing-66-200816932 (2) of the patent scope 1, 3 or 4, wherein the gliadin is wheat wheat gliadin, corn zein, barley barley At least one selected from the group consisting of proteins. 8. A functional chew as claimed in claim 1, 3 or 4, wherein the functional material is self-contained with tea catechin, gallocatechin: gallic acid, grape seed cyanine Prime, French Coastal Pine Bark Extract r Polyphenols, sesame xylans, reduced astaxanthin from Haematococcus, γ-aminobutyric acid, antihypertensive peptide, xylitol, frankincense extract, propolis , sea radish φ sugar, meat 萱蔻 and wormwood extracts, mushrooms, mulberry and monkey mushroom extracts, fucoidan, heat-treated lactic acid bacteria powder, milk Ferritin, isoflavones, ginkgo biloba extract, small sassafras extract, phospholipid lysine, peanut oleic acid, 来自 from fish and DH A highly unsaturated fatty acid, chili powder, ketene, capsaicin Ester, Coenzyme Q -1 0, Alpha Lipoic Acid, Carnitine Hydrochloride, Citrus Extract, Five-Layer Extract, Boots Leaf Extract, Green Bean Extract, Mulberry Leaf Extract, Vitamins, Yellow Green Vegetable Extract Species, royal jelly, calcium compounds, magnesium compounds, # yeast zinc, iron Minerals, nourishing and strong use of herbal extracts, ceramide, hyaluronic acid, cysteine, cystine, camphor extract, copper leaf green. sodium, iron chlorophyll sodium, lactic acid bacteria, inulin, fruit At least one of oligosaccharide, galactose oligosaccharide, xylooligosaccharide, nicotine, caffeine, and theanine is selected to be composed of . 9. A functional chew as claimed in claim 1, 3 or 4, wherein the functional material is derived from polyphenols containing apple anthocyanin, fruit extract, blueberry extract, and black beans. Pigment glycoside, curcumin, tetrahydrocurcumin, sugarcane, octacosanol, collagen, plant-67- 200816932 (3) acid, aspirin, acetaminophen, dl-maleic acid chloride Phenanthine, dl-methylephedrine hydrochloride, citrate citrate, mexican extract, caffeine, allyl isopropylethane acridine, chlorhexidine hydrochloride At least one or more selected from the group consisting of pyridine, potassium cresylate, mountain: grass, 1-menthol, and sodium sulfonate, 10. The function of the third or fourth item of the patent application, wherein the polyphenols are The catechins and the catechins are composed of at least one of anthocyanin, anthocyanin, flavonol, isoflavone, sesamin curcumin and persimmon tannin. 1 1. If the utility of the patent application scope 1, 3 or 4 is a compound, it is a mixture of 1 to 40% of a proteolytic enzyme and a group of 1 2 . The proteolytic enzyme is composed of a filamentous fungus, a bacterial radiobacteria, and a plant-derived proteolytic enzyme. 1 3 . As claimed in claim 1, item 1, 3 or 4, which consists of 5 to 40% of a disintegrating agent. 14. The functional intermediate disintegrating agent according to claim 13 of the patent application is selected from the group consisting of gelatin, casein sodium, casein-white protein, or carrageenan, sanxian gum, gellan gum, , consisting of vegetables, sodium carboxymethylcellulose, calcium carboxymethylcellulose, seaweed, polyvinylpolyrrolidone, and fatty acid glycerides. 1 5 . — A method for producing a functional chew. Protein, wheat gluten and functional materials are ingots. It is composed of dihydrogen phosphate, chlorinated lysine, sulphuric bark, and sakura bark. Sexual chews Gum, fat, quercetin, chewing. a chew, a basidiomycete, a chewing chewable substance, a calcium and a collagen egg yolk, a polysaccharide of sodium citrate, which is solvated with an alcohol or a granule-68-200816932 (4) 16 · as claimed in the patent scope A method for producing a functional chew of 15 items, wherein the ratio of the prolamin to the wheat gluten is 8:2 to 2:8. 1 7 - A method for producing a functional chew, which is obtained by dissolving or granulating alcohol, protein, polyphenols and functional materials. , 1 8 · A method for producing a functional chew, which is obtained by tableting or granulating prolamine, wheat gluten, polyphenols and functional materials. 1 9 The method for producing a functional chew according to claim 18, wherein the ratio of the prolamin to the wheat gluten is 9:9: 0.1 to 2:8. 20. A method of producing a functional chew according to claim 17 or 18, which comprises mixing 1 to 20% of a polyphenol with respect to a total amount of prolamin and wheat gluten. 2 1 • A method for producing a functional φ chew according to the patent application No. 15, 5 or 18, which consists of mixing 1 to 40% of a proteolytic enzyme. Dream 22: A method for producing a functional chew according to claim 15, paragraph 17, or 18, which is composed of 5 to 40% of a disintegrating agent, 〇. 2 3· a method of using a chewable substance, which is chewed as a functional chew according to any one of claims 1 to 8 or item 10 of the patent application, and then further chewed as claimed in claim 1 Composed of functional chews. -69- 200816932 (5) 24. A method of using a functional chew, which is chewed as a functional chew according to item 9 of the patent application, and then further chewed as claimed. The product consists of a functional chew. 25 · A method of using a functional chew, which is chewable, such as: patent application, abandonment, or any of the items of item i or item i. The chew, chewing time is 10 More than a minute, and then add a solid chew or a functional chew with a chewing time of 2 minutes or less. 2 6. A method for using a functional chew, which is chewed as a functional chew according to item 9 of the patent application, having a chewing time of more than 10 minutes, and then adding a chewing time of 2 minutes. The following solid chews or functional chews are formed. 27. The method of using a functional chew according to claim 25 or 26, wherein the proportion of the solid chewable gliadin or gliadin to wheat gluten is 9.9 : 0.1 to 8.1 : 1.9. Φ 2 8 · A method of using a functional chew, which is chewable as claimed in any one of claims 1 to 8 or item 10, chew, chewing time is 1 0 minutes or more, and then add a chewable organic acid tablet to form. 29. A method of using a functional chew, which is chewed as a functional chew according to item 9 of the patent application, having a chewing time of more than 10 minutes, and further adding a chewing agent of organic acid composition. 30. A method of using a functional chew according to claim 28 or 29, wherein the organic acid is from citric acid, malic acid, tartaric acid-70-200816932 (6), succinic acid, gluconic acid, lactic acid, A method of using at least one of acetic acid to form a functional chew, which is chewable as claimed in any one of claims 1 to 8 or 10: chewing The substance, chewing time is more than 10 minutes, and then re-adding the chewing speed collapse to dissolve the ingot. 32. A method for using a functional chew, which is to chew a functional chew as in item 9 of the φ patent application, having a chewing time of more than 10 minutes, and then adding a chewing fast disintegrating tablet. composition. 3 3. A method for using a functional chew according to claim 31 or 3, wherein the fast disintegrating tablet contains a selected from the group consisting of citric acid, malic acid, tartaric acid, succinic acid, gluconic acid, lactic acid, Acetic acid, ascorbic acid organic acid, gelatin, casein sodium, collagen protein, carrageenan, sanxian gum, gellan gum, tragacanth, agar, sodium carboxymethylcellulose, hydroxymethylcellulose A polysaccharide of calcium, sodium alginate, at least one of polyglutamic acid, arginine m, cocoa powder, and cheese powder. -71 -
TW096100689A 2006-10-13 2007-01-08 Functional chewy food and process for production and use thereof TW200816932A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101999582A (en) * 2010-12-25 2011-04-06 河南科技大学 Yam-swimming bladder collagen chewable tabs and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101999582A (en) * 2010-12-25 2011-04-06 河南科技大学 Yam-swimming bladder collagen chewable tabs and preparation method thereof
CN101999582B (en) * 2010-12-25 2012-11-28 河南科技大学 Yam-swimming bladder collagen chewable tabs and preparation method thereof

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