TW200815424A - 2-anilino-4-(heterocyclic)amino-pyrimidines - Google Patents
2-anilino-4-(heterocyclic)amino-pyrimidines Download PDFInfo
- Publication number
- TW200815424A TW200815424A TW096121541A TW96121541A TW200815424A TW 200815424 A TW200815424 A TW 200815424A TW 096121541 A TW096121541 A TW 096121541A TW 96121541 A TW96121541 A TW 96121541A TW 200815424 A TW200815424 A TW 200815424A
- Authority
- TW
- Taiwan
- Prior art keywords
- propyl
- diamine
- phenyl
- pyrimidine
- biphenyl
- Prior art date
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- 239000000203 mixture Substances 0.000 claims abstract description 77
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- -1 imidazolidinium-2-yl Chemical group 0.000 claims description 327
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- 150000001875 compounds Chemical class 0.000 claims description 104
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 43
- FJNLCHNQVJVCPY-UHFFFAOYSA-N 2-n-methoxy-2-n-methyl-4-n,6-n-dipropyl-1,3,5-triazine-2,4,6-triamine Chemical compound CCCNC1=NC(NCCC)=NC(N(C)OC)=N1 FJNLCHNQVJVCPY-UHFFFAOYSA-N 0.000 claims description 42
- 125000000623 heterocyclic group Chemical group 0.000 claims description 42
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- A61P9/08—Vasodilators for multiple indications
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
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- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Heart & Thoracic Surgery (AREA)
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- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| US81395606P | 2006-06-15 | 2006-06-15 |
Publications (1)
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| EP (1) | EP2054392A2 (https=) |
| JP (1) | JP2009540013A (https=) |
| KR (1) | KR20090019011A (https=) |
| CN (1) | CN101506175A (https=) |
| AR (1) | AR061380A1 (https=) |
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| TW (1) | TW200815424A (https=) |
| WO (1) | WO2007146981A2 (https=) |
| ZA (1) | ZA200809941B (https=) |
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| WO2007146977A1 (en) * | 2006-06-15 | 2007-12-21 | Boehringer Ingelheim International Gmbh | 2-anilino-4-aminoalkyleneaminopyrimidines |
| EA200901133A1 (ru) * | 2007-03-20 | 2010-04-30 | Смитклайн Бичем Корпорейшн | Производные дианилинопиримидина как ингибиторы киназы wee1, фармацевтическая композиция и применение |
| CA2693594A1 (en) * | 2007-07-17 | 2009-01-22 | Rigel Pharmaceuticals, Inc. | Cyclic amine substituted pyrimidinediamines as pkc inhibitors |
| WO2010083240A2 (en) * | 2009-01-14 | 2010-07-22 | Rigel Pharmaceuticals, Inc. | Methods for treating inflammatory disorders using 2,4-pyrimidinediamine compounds |
| JP5658685B2 (ja) * | 2009-01-14 | 2015-01-28 | ライジェル ファーマシューティカルズ， インコーポレイテッド | 炎症性障害の治療のための２，４−ピリミジンジアミン化合物 |
| ES2555982T3 (es) * | 2009-01-15 | 2016-01-12 | Rigel Pharmaceuticals, Inc. | Inhibidores de la proteína quinasa C y usos de los mismos |
| AR076024A1 (es) * | 2009-04-03 | 2011-05-11 | Schering Corp | Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos |
| EP2483406A2 (en) | 2009-09-30 | 2012-08-08 | President and Fellows of Harvard College | Methods for modulation of autophagy through the modulation of autophagy-inhibiting gene products |
| US20110130415A1 (en) | 2009-12-01 | 2011-06-02 | Rajinder Singh | Protein kinase c inhibitors and uses thereof |
| JP2013517273A (ja) * | 2010-01-13 | 2013-05-16 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 化合物および方法 |
| US8927547B2 (en) | 2010-05-21 | 2015-01-06 | Noviga Research Ab | Pyrimidine derivatives |
| DK2688883T3 (en) | 2011-03-24 | 2016-09-05 | Noviga Res Ab | pyrimidine |
| CN104169272A (zh) * | 2011-12-23 | 2014-11-26 | 赛尔佐姆有限公司 | 作为激酶抑制剂的嘧啶-2,4-二胺衍生物 |
| CN102746255A (zh) * | 2012-07-24 | 2012-10-24 | 安徽中医学院 | 具有抗肿瘤活性的化合物、制备方法及应用 |
| MX394360B (es) * | 2013-03-14 | 2025-03-24 | Sumitomo Pharma Oncology Inc | Inhibidores de jak2 y alk2 y metodos para su uso. |
| CN106456700B (zh) | 2014-01-29 | 2020-02-18 | 斯特拉斯堡大学 | 糖尿病治疗和预防的新靶标 |
| EP3206691B1 (en) * | 2014-10-14 | 2018-09-19 | Sunshine Lake Pharma Co., Ltd. | Substituted heteroaryl compounds and methods of use |
| CA3012288A1 (en) * | 2016-02-22 | 2017-08-31 | F.Hoffmann-La Roche Ag | Process for the manufacture of 3-piperazin-1-yl-propylamine derivatives |
| EP3421485A1 (en) | 2017-06-30 | 2019-01-02 | Université de Strasbourg | Peptides for treatment and prevention of hyperglycaemia |
| CN112533602A (zh) | 2018-04-05 | 2021-03-19 | 大日本住友制药肿瘤公司 | Axl激酶抑制剂及其用途 |
| MX2021000977A (es) | 2018-07-26 | 2021-04-12 | Sumitomo Pharma Oncology Inc | Metodos para tratar enfermedades asociadas con expresion anormal de receptor de activina a tipo 1 (acvr1) e inhibidores de acvr1 para uso en los mismos. |
| EP3966207B1 (en) | 2019-05-10 | 2023-11-01 | Deciphera Pharmaceuticals, LLC | Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof |
| MX2021013662A (es) | 2019-05-10 | 2022-03-11 | Deciphera Pharmaceuticals Llc | Inhibidores de la autofagia de heteroarilaminopirimidina amida y metodos de uso de estos. |
| IL325201A (en) | 2019-06-17 | 2026-02-01 | Deciphera Pharmaceuticals Llc | Aminopyrimidine amide autophagy inhibitors and methods of using them |
| LT4004002T (lt) | 2019-07-22 | 2024-10-25 | Lupin Limited | Makrocikliniai junginiai kaip sting agonistai ir jų naudojimo būdai bei metodai |
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| EP2297097A2 (en) * | 2008-06-11 | 2011-03-23 | Irm Llc | Compounds and compositions useful for the treatment of malaria |
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2007
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- 2007-06-13 BR BRPI0713696-0A patent/BRPI0713696A2/pt not_active IP Right Cessation
- 2007-06-13 JP JP2009515622A patent/JP2009540013A/ja active Pending
- 2007-06-13 AU AU2007257650A patent/AU2007257650A1/en not_active Abandoned
- 2007-06-13 WO PCT/US2007/071077 patent/WO2007146981A2/en not_active Ceased
- 2007-06-13 MX MX2008016004A patent/MX2008016004A/es not_active Application Discontinuation
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- 2007-06-13 US US11/762,394 patent/US20070293494A1/en not_active Abandoned
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- 2007-06-13 KR KR1020097000717A patent/KR20090019011A/ko not_active Withdrawn
- 2007-06-13 EP EP07798482A patent/EP2054392A2/en not_active Withdrawn
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| CL2007001749A1 (es) | 2008-01-25 |
| ZA200809941B (en) | 2009-07-29 |
| US20070293494A1 (en) | 2007-12-20 |
| RU2008152195A (ru) | 2010-07-20 |
| MX2008016004A (es) | 2009-01-16 |
| AR061380A1 (es) | 2008-08-20 |
| BRPI0713696A2 (pt) | 2012-11-06 |
| AU2007257650A1 (en) | 2007-12-21 |
| US20090227586A1 (en) | 2009-09-10 |
| WO2007146981A3 (en) | 2008-02-21 |
| KR20090019011A (ko) | 2009-02-24 |
| CA2653777A1 (en) | 2007-12-21 |
| IL195864A0 (en) | 2009-09-01 |
| US8354407B2 (en) | 2013-01-15 |
| JP2009540013A (ja) | 2009-11-19 |
| WO2007146981A2 (en) | 2007-12-21 |
| CN101506175A (zh) | 2009-08-12 |
| EP2054392A2 (en) | 2009-05-06 |
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