TW200800919A - Substituted pyrimidinyl oxime kinase inhibitors - Google Patents

Substituted pyrimidinyl oxime kinase inhibitors Download PDF

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Publication number
TW200800919A
TW200800919A TW095147765A TW95147765A TW200800919A TW 200800919 A TW200800919 A TW 200800919A TW 095147765 A TW095147765 A TW 095147765A TW 95147765 A TW95147765 A TW 95147765A TW 200800919 A TW200800919 A TW 200800919A
Authority
TW
Taiwan
Prior art keywords
alkyl
group
alkoxy
amino
aryl
Prior art date
Application number
TW095147765A
Other languages
English (en)
Chinese (zh)
Inventor
Guozhang Xu
Lily Lee
Terry V Hughes
Steven K Wetter
Peter J Connolly
Marta C Abad
Stuart L Emanuel
Prabha S Karnachi
Steven A Middleton
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of TW200800919A publication Critical patent/TW200800919A/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW095147765A 2005-12-21 2006-12-20 Substituted pyrimidinyl oxime kinase inhibitors TW200800919A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75263305P 2005-12-21 2005-12-21

Publications (1)

Publication Number Publication Date
TW200800919A true TW200800919A (en) 2008-01-01

Family

ID=38256842

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095147765A TW200800919A (en) 2005-12-21 2006-12-20 Substituted pyrimidinyl oxime kinase inhibitors

Country Status (3)

Country Link
AR (1) AR058624A1 (es)
TW (1) TW200800919A (es)
WO (1) WO2007081630A2 (es)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015161479A1 (zh) * 2014-04-24 2015-10-29 四川大学 一种嘧啶类化合物的抗宫颈癌用途
TWI750905B (zh) * 2020-11-19 2021-12-21 財團法人國家衛生研究院 噻唑化合物作為蛋白質激酶抑制劑

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7989465B2 (en) 2007-10-19 2011-08-02 Avila Therapeutics, Inc. 4,6-disubstituted pyrimidines useful as kinase inhibitors
US7982036B2 (en) 2007-10-19 2011-07-19 Avila Therapeutics, Inc. 4,6-disubstitued pyrimidines useful as kinase inhibitors
US20090111810A1 (en) * 2007-10-23 2009-04-30 Connolly Peter J Substituted pyrimidine-5-carboxamide and 5-carboxylic ester kinase inhibitors
EP2655362A1 (en) 2010-12-22 2013-10-30 Abbvie Inc. Hepatitis c inhibitors and uses thereof
RU2598849C2 (ru) * 2011-02-24 2016-09-27 Цзянсу Хэнсох Фармасьютикал Ко., Лтд. Содержащие фосфор соединения в качестве ингибиторов протеинкина3
US9464079B2 (en) 2011-03-23 2016-10-11 Semorex Technologies Ltd. Treatment of proliferative disorders with a chemiluminescent agent
CN103058935B (zh) * 2013-01-15 2015-05-06 四川大学 一种嘧啶类化合物及其制备方法和用途
US20160083343A1 (en) 2013-03-15 2016-03-24 Global Blood Therapeutics, Inc Compounds and uses thereof for the modulation of hemoglobin
AR096654A1 (es) * 2013-06-20 2016-01-27 Ab Science Derivados de benzimidazol como inhibidores selectivos de proteína quinasa
EA202092627A1 (ru) 2013-11-18 2021-09-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
CN104744446B (zh) * 2013-12-30 2019-06-25 广东东阳光药业有限公司 杂芳化合物及其在药物中的应用
FI3781561T3 (fi) 2018-04-18 2024-06-13 Constellation Pharmaceuticals Inc Metyyliä muuntavien entsyymien modulaattoreita, niiden koostumuksia ja käyttöjä
EP3797108B1 (en) 2018-05-21 2022-07-20 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
WO2021038419A1 (en) * 2019-08-23 2021-03-04 Insilico Medicine Ip Limited Kinase inhibitors and methods of synthesis and treatment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6878714B2 (en) * 2001-01-12 2005-04-12 Amgen Inc. Substituted alkylamine derivatives and methods of use
DE60234338D1 (de) * 2001-06-01 2009-12-24 Hoffmann La Roche Pyrimidin, triazin und pyrazinderivate als glutamatrezeptoren
HUP0401711A3 (en) * 2001-06-26 2009-07-28 Bristol Myers Squibb Co N-heterocyclic inhibitors of tnf-alpha and pharmaceutical compositions containing them

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015161479A1 (zh) * 2014-04-24 2015-10-29 四川大学 一种嘧啶类化合物的抗宫颈癌用途
US9840474B2 (en) 2014-04-24 2017-12-12 Sichuan University Pyrimidine compounds and use as anti-cervical cancer thereof
TWI750905B (zh) * 2020-11-19 2021-12-21 財團法人國家衛生研究院 噻唑化合物作為蛋白質激酶抑制劑

Also Published As

Publication number Publication date
WO2007081630A3 (en) 2007-12-21
AR058624A1 (es) 2008-02-13
WO2007081630A2 (en) 2007-07-19

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