TW200740425A - Production method of nicotine transdermal preparation - Google Patents

Production method of nicotine transdermal preparation

Info

Publication number
TW200740425A
TW200740425A TW095127447A TW95127447A TW200740425A TW 200740425 A TW200740425 A TW 200740425A TW 095127447 A TW095127447 A TW 095127447A TW 95127447 A TW95127447 A TW 95127447A TW 200740425 A TW200740425 A TW 200740425A
Authority
TW
Taiwan
Prior art keywords
nicotine
production method
adhesive layer
transdermal preparation
adhesive
Prior art date
Application number
TW095127447A
Other languages
Chinese (zh)
Other versions
TWI454258B (en
Inventor
Kazuhisa Ninomiya
Shiro Satoda
Junichi Saito
Hidetoshi Kuroda
Original Assignee
Nitto Denko Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nitto Denko Corp filed Critical Nitto Denko Corp
Publication of TW200740425A publication Critical patent/TW200740425A/en
Application granted granted Critical
Publication of TWI454258B publication Critical patent/TWI454258B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
    • A61F2013/0296—Apparatus or processes for manufacturing adhesive dressings or bandages for making transdermal patches (chemical processes excluded)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention provides a production method of a nicotine transdermal preparation, which includes a step of forming, on a support, an adhesive layer containing an adhesive and a liquid ingredient compatible with the adhesive, and a step of impregnating the adhesive layer with nicotine by continuously applying nicotine to the adhesive layer. The production method of the present invention permits direct application of nicotine to the adhesive layer, which is not possible by conventional techniques, and the nicotine transdermal preparation provided by the method is associated with less physical skin irritation on peeling off and affords a good feeling during adhesion.
TW095127447A 2005-08-01 2006-07-27 Production method of nicotine transdermal preparation TWI454258B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005223475 2005-08-01

Publications (2)

Publication Number Publication Date
TW200740425A true TW200740425A (en) 2007-11-01
TWI454258B TWI454258B (en) 2014-10-01

Family

ID=37075990

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095127447A TWI454258B (en) 2005-08-01 2006-07-27 Production method of nicotine transdermal preparation

Country Status (9)

Country Link
US (1) US20070026055A1 (en)
EP (1) EP1749521A1 (en)
JP (1) JP4970867B2 (en)
KR (2) KR101316962B1 (en)
CN (1) CN1907273B (en)
CA (1) CA2554728C (en)
IL (1) IL177071A0 (en)
RU (1) RU2403018C2 (en)
TW (1) TWI454258B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4981402B2 (en) * 2005-10-13 2012-07-18 日東電工株式会社 Nicotine transdermal absorption preparation and method for producing the same
EP1774964B1 (en) 2005-10-13 2014-08-06 Nitto Denko Corporation Nicotine transdermal preparation and production method thereof
JP4327841B2 (en) * 2006-12-20 2009-09-09 日東電工株式会社 Apparatus and method for producing transdermal absorption preparation
CA2963423C (en) * 2007-03-30 2020-07-28 Philip Morris Products S.A. Device and method for delivery of a medicament
JP5289862B2 (en) 2008-08-28 2013-09-11 日東電工株式会社 Patch
CN103611391B (en) 2013-12-12 2016-01-20 北京博源恒升高科技有限公司 Glycols composite solution removes the method for SOx in gas
CN106579540A (en) * 2016-12-30 2017-04-26 中国烟草总公司广东省公司 Ointment type past cigarette and preparation method
CN113876014B (en) * 2021-09-06 2022-10-18 湖北中烟工业有限责任公司 Atomizing agent containing alkylated glycerol and preparation method and application thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4373962A (en) 1981-06-08 1983-02-15 Basf Wyandotte Corporation Surface treated alkali blue pigment
US6139868A (en) * 1986-08-28 2000-10-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Transdermal therapeutic system, its use and production process
DE3629304A1 (en) 1986-08-28 1988-03-24 Lohmann Gmbh & Co Kg TRANSDERMAL THERAPEUTIC SYSTEM, ITS USE AND METHOD FOR THE PRODUCTION THEREOF
IL86170A (en) * 1987-05-01 1992-12-01 Elan Transdermal Ltd Preparations and compositions comprising nicotine for percutaneous administration
DE3727232A1 (en) * 1987-08-14 1989-02-23 Lohmann Therapie Syst Lts METHOD FOR PRODUCING A PHARMACEUTICAL AND / OR DOSAGE FOR MEDICINAL ACTIVE SUBSTANCES
US4915950A (en) 1988-02-12 1990-04-10 Cygnus Research Corporation Printed transdermal drug delivery device
CA2142871A1 (en) * 1992-08-25 1994-03-03 Jesus Miranda Printed transdermal drug delivery device
AU676430B2 (en) * 1994-03-07 1997-03-06 Theratech, Inc. Drug-containing adhesive composite transdermal delivery device
ATE194281T1 (en) * 1994-09-14 2000-07-15 Minnesota Mining & Mfg TRANSDERMAL ACTIVE RELEASE MATRIX
US5688523A (en) * 1995-03-31 1997-11-18 Minnesota Mining And Manufacturing Company Method of making a pressure sensitive skin adhesive sheet material
CN1055619C (en) * 1996-08-13 2000-08-23 李建民 Health Vitamin B6 Cigarette Plaster and its prepn. method
JPH1094595A (en) * 1996-09-25 1998-04-14 Teijin Ltd New pressure-sensitive adhesive and drug formulation for medical use
DE19847715A1 (en) * 1998-10-16 2000-04-20 Lohmann Therapie Syst Lts Treatment of schizophrenia symptoms without side effects, by transdermal administration of nicotine or its salt
DE69916492T3 (en) 1998-12-07 2008-08-14 J. Dev Ltd., Athlone PLASTER FOR THE TRANSDERMAL APPLICATION OF VOLATILE, LIQUID ACTIVE SUBSTANCES
DE19913732A1 (en) * 1999-03-26 2000-09-28 Lohmann Therapie Syst Lts Nicotine TTS with the addition of monoterpene ketones
DE10110391A1 (en) * 2001-03-03 2002-09-26 Lohmann Therapie Syst Lts Highly flexible nicotine transdermal therapeutic system with nicotine as active ingredient
DE10256775A1 (en) * 2002-12-05 2004-06-24 Lts Lohmann Therapie-Systeme Ag Preparation of film forming composition for transmucosal delivery of nicotine used for treating tobacco addiction, includes converting nicotine free base to its salt with acid and/or incorporation of nicotine as salt
DE102005010255A1 (en) * 2005-03-07 2006-09-14 Lts Lohmann Therapie-Systeme Ag Fiber-free transdermal therapeutic system and method for its production
EP1774964B1 (en) * 2005-10-13 2014-08-06 Nitto Denko Corporation Nicotine transdermal preparation and production method thereof
JP4327841B2 (en) * 2006-12-20 2009-09-09 日東電工株式会社 Apparatus and method for producing transdermal absorption preparation
JP5227041B2 (en) * 2007-02-28 2013-07-03 日東電工株式会社 Drug-containing patch preparation

Also Published As

Publication number Publication date
US20070026055A1 (en) 2007-02-01
EP1749521A1 (en) 2007-02-07
JP2007063260A (en) 2007-03-15
TWI454258B (en) 2014-10-01
RU2403018C2 (en) 2010-11-10
CA2554728C (en) 2013-12-31
KR20070015874A (en) 2007-02-06
RU2006127493A (en) 2008-02-10
CN1907273A (en) 2007-02-07
KR20130042521A (en) 2013-04-26
CA2554728A1 (en) 2007-02-01
JP4970867B2 (en) 2012-07-11
CN1907273B (en) 2011-12-28
KR101316962B1 (en) 2013-10-11
IL177071A0 (en) 2006-12-10

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees