TW200640854A - Methods of making pravastatin sodium - Google Patents

Methods of making pravastatin sodium

Info

Publication number
TW200640854A
TW200640854A TW095104350A TW95104350A TW200640854A TW 200640854 A TW200640854 A TW 200640854A TW 095104350 A TW095104350 A TW 095104350A TW 95104350 A TW95104350 A TW 95104350A TW 200640854 A TW200640854 A TW 200640854A
Authority
TW
Taiwan
Prior art keywords
methods
pravastatin sodium
making
theta
degrees
Prior art date
Application number
TW095104350A
Other languages
English (en)
Inventor
Vilmos Keri
Arvai Edit Nagyne
Zoltan Czovek
Adrienne Kovacsne-Mezei
Istvan Viktor Katai
Racz Csilla Nemethne
Original Assignee
Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag filed Critical Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag
Publication of TW200640854A publication Critical patent/TW200640854A/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/22Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
    • C07C69/33Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/48Separation; Purification; Stabilisation; Use of additives
    • C07C67/52Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
TW095104350A 2005-02-09 2006-02-09 Methods of making pravastatin sodium TW200640854A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65173805P 2005-02-09 2005-02-09

Publications (1)

Publication Number Publication Date
TW200640854A true TW200640854A (en) 2006-12-01

Family

ID=36499320

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095104350A TW200640854A (en) 2005-02-09 2006-02-09 Methods of making pravastatin sodium

Country Status (9)

Country Link
US (1) US20060194984A1 (zh)
EP (1) EP1833780A1 (zh)
JP (1) JP2007533663A (zh)
CN (1) CN101115706A (zh)
CA (1) CA2595635A1 (zh)
IL (1) IL183378A0 (zh)
MX (1) MX2007009229A (zh)
TW (1) TW200640854A (zh)
WO (1) WO2006086680A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090076148A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched pravastatin
CN101648867B (zh) * 2009-09-04 2012-07-11 天津大学 一种普伐他汀钠晶型及其制备方法和应用
CN105949062B (zh) * 2016-06-24 2017-06-13 广东蓝宝制药有限公司 一种规模化制备普伐他汀钠d型晶体的工艺

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4319039A (en) * 1979-06-15 1982-03-09 Merck & Co., Inc. Preparation of ammonium salt of hypocholesteremic fermentation product
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
EP0215665B1 (en) * 1985-09-13 1991-11-21 Sankyo Company Limited Hydroxy-ml-236b derivatives, their preparation and use
US4857547A (en) * 1988-01-07 1989-08-15 Merck & Co., Inc. Novel HMG-CoA reductase inhibitors
US4857522A (en) * 1988-03-21 1989-08-15 E. R. Squibb & Sons, Inc. Derivatives of pravastatin for inhibiting cholesterol biosynthesis
US5180589A (en) * 1988-03-31 1993-01-19 E. R. Squibb & Sons, Inc. Pravastatin pharmaceuatical compositions having good stability
US5099035A (en) * 1989-02-27 1992-03-24 E. R. Squibb & Sons, Inc. Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same
US5140012A (en) * 1990-05-31 1992-08-18 E. R. Squibb & Sons, Inc. Method for preventing onset of restenosis after angioplasty employing pravastatin
US5157025A (en) * 1991-04-01 1992-10-20 E. R. Squibb & Sons, Inc. Method for lowering serum cholesterol employing a phosphorus containing ace inhibitor alone or in combination with a cholesterol lowering drug
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
US5616595A (en) * 1995-06-07 1997-04-01 Abbott Laboratories Process for recovering water insoluble compounds from a fermentation broth
US5883109A (en) * 1996-07-24 1999-03-16 Bristol-Myers Squibb Company Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug
KR100210482B1 (ko) * 1997-04-10 1999-07-15 김종인 스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법
SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
MXPA02005283A (es) * 1999-11-30 2003-10-06 Biogal Gyogyszergyar Proceso para recuperar compuestos estatina de un caldo de fermentacion.
PL364929A1 (en) * 1999-12-14 2004-12-27 Biogal Gyogyszergyar Rt. Novel forms of pravastatin sodium

Also Published As

Publication number Publication date
US20060194984A1 (en) 2006-08-31
MX2007009229A (es) 2007-09-25
JP2007533663A (ja) 2007-11-22
WO2006086680A1 (en) 2006-08-17
EP1833780A1 (en) 2007-09-19
CN101115706A (zh) 2008-01-30
IL183378A0 (en) 2007-09-20
CA2595635A1 (en) 2006-08-17

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TW200640854A (en) Methods of making pravastatin sodium
SA114350792B1 (ar) شكل متبلر جديد من ملح الـبيميرولاست