TW200639170A - Pharmaceutical compounds - Google Patents

Pharmaceutical compounds

Info

Publication number
TW200639170A
TW200639170A TW095101704A TW95101704A TW200639170A TW 200639170 A TW200639170 A TW 200639170A TW 095101704 A TW095101704 A TW 095101704A TW 95101704 A TW95101704 A TW 95101704A TW 200639170 A TW200639170 A TW 200639170A
Authority
TW
Taiwan
Prior art keywords
kinases
methyl
group
compounds
pharmaceutical compounds
Prior art date
Application number
TW095101704A
Other languages
Chinese (zh)
Inventor
Valerio Berdini
Adrian Liam Gill
Eva Figueroa Navarro
Michael Alistair O'brien
Theresa Rachel Phillips
Gary Trewartha
Andrew James Woodhead
Paul Graham Wyatt
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0501480A external-priority patent/GB0501480D0/en
Priority claimed from GB0501748A external-priority patent/GB0501748D0/en
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of TW200639170A publication Critical patent/TW200639170A/en

Links

Abstract

The invention provides compounds of the formula (I), or a salt, tautomer, solvate or N-oxides thereof; wherein: R1 is selected from (a) 2,6-dichlorophenyl; (b) 2,6-difluorophenyl; (c) a 2,3,6-trisubstituted phenyl group wherein the substituents are fluorine, chlorine, methyl or methoxy; and (d) a group R0 wherein R0 is a 3-12 membered carbocyclic or heterocyclic group; or optionally substituted C1-8 hydrocarbyl; R2a and R2b are each hydrogen or methyl; and R3 is as defined in the claims. The compounds have activity as inhibitors of Cyclin Dependent Kinases (CDK) and Glycogen Synthase Kinases (GSK) kinases and are useful in the treatment or prophylaxis of disease states or conditions mediated by the kinases.
TW095101704A 2005-01-21 2006-01-17 Pharmaceutical compounds TW200639170A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US64621705P 2005-01-21 2005-01-21
GB0501480A GB0501480D0 (en) 2005-01-22 2005-01-22 Pharmaceutical compounds
GB0501748A GB0501748D0 (en) 2005-01-27 2005-01-27 Pharmaceutical compounds
US65133905P 2005-02-09 2005-02-09

Publications (1)

Publication Number Publication Date
TW200639170A true TW200639170A (en) 2006-11-16

Family

ID=45699652

Family Applications (3)

Application Number Title Priority Date Filing Date
TW095101695A TW200637858A (en) 2005-01-21 2006-01-17 Pharmaceutical compounds
TW095101704A TW200639170A (en) 2005-01-21 2006-01-17 Pharmaceutical compounds
TW095101705A TW200640922A (en) 2005-01-21 2006-01-17 Pharmaceutical compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
TW095101695A TW200637858A (en) 2005-01-21 2006-01-17 Pharmaceutical compounds

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW095101705A TW200640922A (en) 2005-01-21 2006-01-17 Pharmaceutical compounds

Country Status (3)

Country Link
GT (3) GT200600015A (en)
MY (1) MY139848A (en)
TW (3) TW200637858A (en)

Also Published As

Publication number Publication date
TW200640922A (en) 2006-12-01
GT200600014A (en) 2006-08-09
GT200600016A (en) 2006-08-09
GT200600015A (en) 2006-08-09
TW200637858A (en) 2006-11-01
MY139848A (en) 2009-11-30

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