TW200604153A - Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes - Google Patents

Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes

Info

Publication number
TW200604153A
TW200604153A TW094112935A TW94112935A TW200604153A TW 200604153 A TW200604153 A TW 200604153A TW 094112935 A TW094112935 A TW 094112935A TW 94112935 A TW94112935 A TW 94112935A TW 200604153 A TW200604153 A TW 200604153A
Authority
TW
Taiwan
Prior art keywords
synthesis
semi
taxanes
mixture
isolation
Prior art date
Application number
TW094112935A
Other languages
English (en)
Inventor
Ragina Naidu
Samuel Siang Kiang Foo
Original Assignee
Phytogen Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/831,648 external-priority patent/US20050240036A1/en
Priority claimed from US10/838,653 external-priority patent/US20050250954A1/en
Application filed by Phytogen Life Sciences Inc filed Critical Phytogen Life Sciences Inc
Publication of TW200604153A publication Critical patent/TW200604153A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW094112935A 2004-04-23 2005-04-22 Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes TW200604153A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/831,648 US20050240036A1 (en) 2004-04-23 2004-04-23 Semi-synthesis of taxane intermediates from a mixture of taxanes
US10/838,653 US20050250954A1 (en) 2004-05-04 2004-05-04 Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes

Publications (1)

Publication Number Publication Date
TW200604153A true TW200604153A (en) 2006-02-01

Family

ID=34967185

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094112935A TW200604153A (en) 2004-04-23 2005-04-22 Semi-synthesis and isolation of taxane intermediates from a mixture of taxanes

Country Status (5)

Country Link
US (1) US7838694B2 (zh)
EP (1) EP2091932B1 (zh)
CA (1) CA2563838C (zh)
TW (1) TW200604153A (zh)
WO (1) WO2005105767A1 (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7893283B2 (en) * 2004-06-04 2011-02-22 Chatham Biotec, Limited Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
US20050288520A1 (en) 2004-06-25 2005-12-29 Phytogen Life Sciences Inc. One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
US20050288521A1 (en) * 2004-06-29 2005-12-29 Phytogen Life Sciences Inc. Semi-synthetic conversion of paclitaxel to docetaxel
GB0701523D0 (en) 2007-01-26 2007-03-07 Chatham Biotec Ltd Semi-synthetic process for the preparation of taxane derivatives
CN101074219B (zh) * 2007-06-27 2010-05-19 西安天丰生物科技有限公司 一种从红豆杉中分离提取10-去乙酰基巴卡丁ⅲ的方法
AU2007361151A1 (en) * 2007-11-15 2009-05-22 Institute Of Mataria Medica, Chinese Academy Of Medical Sciences Cephalomannine derivatives and their preparation, medicinal composition and use
CN103804441A (zh) * 2012-11-15 2014-05-21 刘胜远 一种从含7-木糖-10-去乙酰基紫杉醇的浸膏分离和提纯7-木糖-10-去乙酰基紫杉醇的方法
CN104592173A (zh) * 2014-12-31 2015-05-06 宁波绿之健药业有限公司 一种由9-dhb合成10-dab的制备方法
US20210284595A1 (en) * 2018-07-05 2021-09-16 Reliance Industries Limited Spirobiindane derivatives and a process for preparation thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY110249A (en) 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
US5380916A (en) * 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
US5284865A (en) 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
ATE181551T1 (de) * 1992-04-17 1999-07-15 Abbott Lab Taxol-derivate
US5319112A (en) 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5679807A (en) 1995-01-30 1997-10-21 Hauser, Inc. Preparation of taxol and docetaxel through primary amines
CA2188190A1 (en) * 1996-10-18 1998-04-18 Sarala Balachandran The semi-synthesis of a protected bacatin iii compound
CA2204197A1 (en) * 1997-05-01 1998-11-01 Jian Liu Process for converting 9-dihydro-13-acetylbaccatin iii into taxol and derivatives thereof
AU3402699A (en) * 1998-04-20 1999-11-08 Gaetan Caron The semi-synthesis of baccatin iii
US6136989A (en) * 1998-12-30 2000-10-24 Phytogen Life Sciences, Incorporated Method for high yield and large scale extraction of paclitaxel from paclitaxel-containing material
US20010041803A1 (en) * 2000-03-21 2001-11-15 Kasitu Gertrude C. Conversion of 9-dihydro-13-acetylbaccatin III to baccatin III and 10-deacetyl baccatin III
US6812356B2 (en) * 2002-09-26 2004-11-02 John Findlay Conversion 9-dihydro-13-acetylbaccatin III into 10-deacetylbaccatin III
ATE431343T1 (de) 2002-10-09 2009-05-15 Chatham Biotec Ltd Thio-analoga von paclitaxel und deren vorprodukte
US7202370B2 (en) 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
EP1732911A2 (en) 2004-02-24 2006-12-20 Chatham Biotec Ltd. Semi-synthesis of taxane intermediates and aziridine analogues and their conversion to paclitaxel and docetaxel
US20050272807A1 (en) 2004-06-04 2005-12-08 Phytogen Life Sciences Inc. Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
US7893283B2 (en) 2004-06-04 2011-02-22 Chatham Biotec, Limited Semi-synthesis of taxane intermediates and their conversion to paclitaxel and docetaxel
US20050288520A1 (en) 2004-06-25 2005-12-29 Phytogen Life Sciences Inc. One pot synthesis of taxane derivatives and their conversion to paclitaxel and docetaxel
US20050288521A1 (en) 2004-06-29 2005-12-29 Phytogen Life Sciences Inc. Semi-synthetic conversion of paclitaxel to docetaxel

Also Published As

Publication number Publication date
CA2563838C (en) 2012-06-19
US7838694B2 (en) 2010-11-23
US20080146824A1 (en) 2008-06-19
EP2091932B1 (en) 2013-12-11
WO2005105767A1 (en) 2005-11-10
EP2091932A1 (en) 2009-08-26
CA2563838A1 (en) 2005-11-10

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