TW200602077A - Compositions as adjuvants to improve immune responses to vaccines and methods of use - Google Patents

Compositions as adjuvants to improve immune responses to vaccines and methods of use

Info

Publication number
TW200602077A
TW200602077A TW094109182A TW94109182A TW200602077A TW 200602077 A TW200602077 A TW 200602077A TW 094109182 A TW094109182 A TW 094109182A TW 94109182 A TW94109182 A TW 94109182A TW 200602077 A TW200602077 A TW 200602077A
Authority
TW
Taiwan
Prior art keywords
targeting molecule
compositions
methods
tim targeting
vaccines
Prior art date
Application number
TW094109182A
Other languages
English (en)
Inventor
Hoo William Soo
Eric R Jensen
Thomas Moll
Dennis J Carlo
Brian K Helmich
Soonpin Yei
Jayant Thatte
Original Assignee
Telos Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Telos Pharmaceuticals Llc filed Critical Telos Pharmaceuticals Llc
Publication of TW200602077A publication Critical patent/TW200602077A/zh

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    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K2039/55516Proteins; Peptides
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    • A61K2039/6031Proteins
    • A61K2039/6056Antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
TW094109182A 2004-03-24 2005-03-24 Compositions as adjuvants to improve immune responses to vaccines and methods of use TW200602077A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US55582704P 2004-03-24 2004-03-24
US58247904P 2004-06-23 2004-06-23
PCT/US2005/009480 WO2005097211A2 (en) 2004-03-24 2005-03-22 Compositions as adjuvants to improve immune responses to vaccines and methods of use
US11/087,177 US20050276756A1 (en) 2004-03-24 2005-03-22 Compositions as adjuvants to improve immune responses to vaccines and methods of use

Publications (1)

Publication Number Publication Date
TW200602077A true TW200602077A (en) 2006-01-16

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TW094109182A TW200602077A (en) 2004-03-24 2005-03-24 Compositions as adjuvants to improve immune responses to vaccines and methods of use

Country Status (13)

Country Link
US (1) US20050276756A1 (zh)
EP (1) EP1740224A4 (zh)
JP (1) JP2007530560A (zh)
KR (1) KR20070037570A (zh)
AU (1) AU2005231685A1 (zh)
BR (1) BRPI0509139A (zh)
CA (1) CA2560941A1 (zh)
EA (1) EA200601761A1 (zh)
IL (1) IL178219A0 (zh)
MX (1) MXPA06010844A (zh)
NO (1) NO20064781L (zh)
TW (1) TW200602077A (zh)
WO (1) WO2005097211A2 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI629483B (zh) * 2010-06-11 2018-07-11 協和醱酵麒麟有限公司 anti-TIM-3 antibody

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7935675B1 (en) 1994-07-15 2011-05-03 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
SK285461B6 (sk) * 1996-05-24 2007-02-01 Biogen Idec Ma Inc. Izolovaný polypeptid KIM, modulátor tkanivovej regenerácie a nukleová kyselina, ktorá ho kóduje, spôsob prípravy polypeptidu a farmaceutická kompozícia obsahujúca polypeptid
US8709412B2 (en) 2001-06-29 2014-04-29 The Board Of Trustees Of The Leland Stanford Junior University Modulation of TIM receptor activity in combination with cytoreductive therapy
ES2311122T3 (es) * 2002-12-30 2009-02-01 Biogen Idec Ma Inc. Antagonistas de kim-1 y uso para la modulacion del sistema inmune.
RU2006114694A (ru) * 2003-10-03 2007-11-10 Брихэм Энд Уимен`З Хоспитал (Us) Tim-3-полипептиды
TW200539890A (en) * 2004-03-12 2005-12-16 Brigham & Womens Hospital Methods of modulating immune responses by modulating tim-1, tim-2 and tim-4 function
DE602006016413D1 (de) * 2005-03-02 2010-10-07 Biogen Idec Inc Kim-1-antikörper zur behandlung von th2-vermittelten erkrankungen
EP2021021A2 (en) 2006-05-12 2009-02-11 Oklahoma Medical Research Foundation Anthrax compositions and methods of use and production
WO2009049115A1 (en) * 2007-10-11 2009-04-16 University Of Maryland Methods for the treatment of viral conditions
WO2009052623A1 (en) 2007-10-26 2009-04-30 Governing Council Of The University Of Toronto Therapeutic and diagnostic methods using tim-3
WO2009064290A1 (en) * 2007-11-13 2009-05-22 Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services Structure of tim family members
EP2252319A2 (en) * 2008-01-29 2010-11-24 The Brigham and Women's Hospital, Inc. Methods for modulating a population of myeloid-derived suppressor cells and uses thereof
WO2010053610A2 (en) * 2008-07-30 2010-05-14 Emergent Biosolutions, Inc. Stable anthrax vaccine formulations
EP2417984B1 (en) 2009-04-10 2016-03-30 Kyowa Hakko Kirin Co., Ltd. Method for treatment of blood tumor using anti-tim-3 antibody
US9623117B2 (en) * 2011-04-04 2017-04-18 Wisconsin Alumni Research Foundation Method for selective targeting and entry of bacterial toxins to cells
DK2706988T3 (da) * 2011-05-12 2020-01-20 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Liposomer omfattende polymer konjugerede lipider og relateret brug
EP2931317A2 (en) * 2012-12-13 2015-10-21 Children's Medical Center Corporation Compositions and methods for inhibiting viral entry
EP3049442A4 (en) 2013-09-26 2017-06-28 Costim Pharmaceuticals Inc. Methods for treating hematologic cancers
WO2015100344A1 (en) 2013-12-27 2015-07-02 Emergent Product Development Gaithersburg Inc. Temperature stable vaccine formulations
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
CN104072615B (zh) 2014-01-26 2016-08-24 中国人民解放军军事医学科学院基础医学研究所 一种能阻断Tim-3信号通路的人Tim-3融合蛋白
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
CA2946606C (en) * 2014-05-13 2023-06-06 Bavarian Nordic A/S Combination therapy for treating cancer with a poxvirus expressing a tumor antigen and an antagonist of tim-3
US10369219B2 (en) 2014-08-04 2019-08-06 Nitto Denko Corporation Composition for enhancing induction of humoral immunity, and vaccine pharmaceutical composition
US9993551B2 (en) 2014-09-13 2018-06-12 Novartis Ag Combination therapies of EGFR inhibitors
WO2016123285A1 (en) 2015-01-29 2016-08-04 The Trustees Of The University Of Pennsylvania Checkpoint inhibitor and vaccine combinations and use of same for immunotherapy
MX2018014387A (es) 2016-05-27 2019-03-14 Agenus Inc Anticuerpos anti proteina inmunoglobulina de linfocitos t y dominio de mucina 3 (tim-3) y métodos para usarlos.
JP7027401B2 (ja) 2016-07-14 2022-03-01 ブリストル-マイヤーズ スクイブ カンパニー Tim3に対する抗体およびその使用
JP2019536471A (ja) 2016-09-27 2019-12-19 セロ・セラピューティクス・インコーポレイテッドCERO Therapeutics, Inc. キメラエンガルフメント受容体分子
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
CA3073421A1 (en) 2017-09-26 2019-04-04 Daniel Mark COREY Chimeric engulfment receptor molecules and methods of use
US11197910B1 (en) * 2020-08-19 2021-12-14 Vitruviae LLC Fusion proteins for the diagnosis, prophylaxis and treatment of infectious diseases
WO2023201221A1 (en) * 2022-04-11 2023-10-19 Duke University Recombinant tim-4 protein, chimeric antigen receptor (car) t cell delivery system and methods of making and using same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6066322A (en) * 1995-03-03 2000-05-23 Millennium Pharmaceuticals, Inc. Methods for the treatment of immune disorders
WO2003002722A2 (en) * 2001-06-29 2003-01-09 The Board Of Trustees Of The Leland Stanford Junior University T cell regulatory genes and methods of use thereof
AU2003303082B2 (en) * 2002-01-30 2009-07-02 Dana-Farber Cancer Institute, Inc. Compositions and methods related to TIM-3, a Th1-specific cell surface molecule
TW200539890A (en) * 2004-03-12 2005-12-16 Brigham & Womens Hospital Methods of modulating immune responses by modulating tim-1, tim-2 and tim-4 function

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI629483B (zh) * 2010-06-11 2018-07-11 協和醱酵麒麟有限公司 anti-TIM-3 antibody

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