TW200538143A - Method for preparation of Chinese herbal medicine extract - Google Patents

Method for preparation of Chinese herbal medicine extract Download PDF

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TW200538143A
TW200538143A TW93115297A TW93115297A TW200538143A TW 200538143 A TW200538143 A TW 200538143A TW 93115297 A TW93115297 A TW 93115297A TW 93115297 A TW93115297 A TW 93115297A TW 200538143 A TW200538143 A TW 200538143A
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chinese herbal
herbal medicine
extract
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preparing
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TW93115297A
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TWI321473B (en
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cong-hui Yang
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cong-hui Yang
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Abstract

The invention concerns a method for preparation of Chinese herbal medicine extract, wherein herbal medicines are cooked with water and distilled with solvent, and the extracts generated are well mixed for uniformity, followed by a precipitation procedure to eliminate harmful heavy metals from the extract essence, such as cadmium, in order to protect the safety of user.

Description

200538143200538143

五、發明說明(1) 【發明所屬之技術領域] 本案係一種中草藥藥材,例如巴西蘑菇萃取 方法,其係將藥材經由水熬煉,以及將藥材經由溶摇: 分餾後,所分別獲得之萃取液經由掺合均質化,3徒析 析離步驟,以去除萃取精華液中之有害重金屬j經由一 以確保服用者安全者。 列如編’ 【先前技術】 按一般 置於容器中 之有效成份 驟,並泛見 材中所有成 效成份,並 來。故須要 取成份與避 而中草 如在曰本39 即發表一篇 發各界之注 舉行時,於 成份’並可 經由實 包括中性多 糖及核酸成 中草藥中草藥之萃取液之製備, ,並加水以加熱設備熬煮,使筚材呈古樂材 ,因加熱作用而溶解於水中,; 於吾人所熟知之熬素中草藥的過程。伸二 =於ί ’故熬煮並不會完全能析離所有有 且::-些不必要的成份’如重金屬等分解: 2之製備程序與處理過程,以保證有效萃 免有害之重金屬殘留。 卒 藥之療效,自古以來,即為東方 屆癌症學會總會中’日本三重大學部伊;博= 巴西蘑菇(姬松茸)具抗癌作用之論文後,即引 意。尤其{,第九屆世界免疫學大會於舊金山 會中亦證實巴西蘑菇含有可抑制癌細胞增殖的 強化免疫力,降低糖值,預防肝病等功能。 驗證實,巴西磨菇中所具有抗癌作用之多醣體 醣的/3-(1-6)-1)葡聚糖、α葡聚糖、酸性雜聚 份的RNA等成份。其中,巴西㈣中之多膽體V. Description of the invention (1) [Technical field to which the invention belongs] This case is a method of extracting Chinese herbal medicines, such as Brazilian mushrooms, which is the method of refining medicinal materials by water and dissolving the medicinal materials by dissolving and distilling: the fractions are obtained by extraction The solution is homogenized by blending and 3 steps of separation and separation to remove harmful heavy metals j in the extract essence to ensure the safety of the user. Listed as edited. [Previous technology] The effective ingredients in the container are generally placed in the container, and all the effective ingredients in the material are listed. Therefore, it is necessary to take the ingredients and avoid the Chinese herbs, such as in the 39th edition of the Japanese, that is, when publishing a note from all walks of life, the ingredients can be prepared by including neutral polysaccharides and nucleic acids into Chinese herbal medicine, and add water. Use the heating equipment to cook, so that the scallion material is ancient music material, which is dissolved in water due to the heating effect; in the process of boiling Chinese herbal medicine that is well known to me. No. 2 = Yu ‘So cooking does not completely separate all and ::-some unnecessary ingredients’ such as heavy metals decomposition: 2 The preparation procedures and processing procedures to ensure the effective extraction of harmful heavy metal residues. Since ancient times, the efficacy of stroke medicine has been the “Mie University of Japan” in the General Conference of the Eastern Cancer Society; Bo = The Brazilian mushroom (Agaricus blazei) has an anti-cancer effect. In particular {, the Ninth World Conference on Immunology also confirmed in the San Francisco meeting that Brazilian mushrooms contain functions that can strengthen the immunity of cancer cells, reduce sugar value, and prevent liver disease. It has been verified that the polysaccharides of the anti-cancer effect of Brazilian mushrooms are / 3- (1-6) -1) glucan, α-glucan, and acid heteropolymer RNA. Among them, the bravery in Brazil

200538143 五、發明說明(2) 内有種其他蕈類 結合後,經由消 之蕈類即使服用 因此,基於 在栽培過程中, 屬,使培植出之 時,在保存製程 之,中草藥之萃 的關鍵技術,目 含量存在之困擾 過量服用,會傷 功能之排毒能力 呆症荨’因此如 關業者亟待克服 【發明内容】 有鑑於此, 究,希冀克服藥 於萃取液中之嚴 體有害的重金屬 而發展出本案之 為達成上述 取液之製備方法 材置於兩容器内 經由一熬煉處理 多醣體 化器官 熬煮後 巴西蘑 因土壤 巴西蘑 中亦有 取,取 前如美 ,如果 肝損腎 ’骨骼 何利用 之難題 所沒有 為人體 之萃取 菇之療 在肥料 菇亦攝 使用福 決於最 、日、 鎘含量 ,例如 產生異 析離技 的特徵, 所吸收, 液亦不為 效,是以 或化學污 取過量的 馬林化學 終端之處 德等國皆 未在安全 會造成腎 常疼痛, 術將重金 就是它 而不具 人體所 各地爭 染下, 有毒重 藥品之 理技術 難突破 值内之 功能障 甚至會 屬毒物 會與蛋白質 備這種特性 吸收。 相栽培,唯 而含有重金 金屬。同 慮。總而言 ’亦即萃取 重金屬-鎘 萃取液,若 礙,影響肝 造成老人癡 渡除,乃相 本案申請人本於多年來從事藥理學之研 材’尤其是中草藥於萃取時,重金屬存在 重缺失,期能通過一析離技術,俾將對人 ’例如鎘濾除之,經再三實驗與測試,進 「中草藥藥材萃取液之製備方法」。 之目的,本案主要提供一種中草藥藥材萃 ’其包括:一提煉步驟,其係取定量之藥 ’並分別添加適量的水及溶劑,而後各自 及一分餾化處理,俾分別獲得有效微量元200538143 V. Description of the invention (2) There is a combination of other mushrooms in the mushroom. Even if the mushroom is consumed, it is based on the cultivation process, the genus, the time of the cultivation, the key to the extraction of Chinese herbal medicine in the preservation process. Technology, the presence of the content of the problem, the excessive detoxification, the detoxification ability that will damage the function, so it is urgent for the practitioners to overcome the problem [Summary of the Invention] In view of this, we hope to overcome the severe and harmful heavy metals in the extract. Developed in this case the preparation method to achieve the above-mentioned liquid extraction. The materials are placed in two containers and processed through a refining process. Polysaccharides are also obtained from the Brazilian mushrooms after being boiled. 'The problem of how to use the bones is not the treatment of the human extracting mushrooms. The use of fertilizers in mushrooms depends on the maximum, daily, and cadmium content. For example, the characteristics of heterogeneous separation and absorption are not effective. The Marin chemical terminal where excessive chemical pollution is taken or the place where Germany and other countries are not safe will cause kidney pain. Under the influence of various parts of the human body, the physical technology of toxic and heavy drugs is difficult to break through. The functional dysfunction can even be a poison and can be absorbed by proteins. Phase cultivation, but contains heavy gold metal. Same consideration. In summary, 'that is, the extraction of heavy metal-cadmium extract, if it interferes with the liver and causes the elderly to get rid of it, it is the same as the applicant who has been engaged in pharmacological research for many years', especially the extraction of heavy metals in Chinese herbal medicines. If it is missing, it is possible to use a dissociation technique to filter out humans such as cadmium. After repeated experiments and tests, enter the "preparation method of Chinese herbal medicine extract". For the purpose of this case, this case mainly provides a Chinese herbal medicine extract, which includes: a refining step, which takes a certain amount of medicine, and adds appropriate amounts of water and solvent, and then each and a fractionation treatment, respectively, to obtain effective microelements.

第5頁 200538143 五、發明說明(3) 素溶於水之第一萃取液,以及有效微量元素溶於溶劑,並 將該溶劑分,提析而出之第二萃取液;一摻合步驟,係該 第一及第二萃取液混合,並經由攪拌,而獲得一均質化= 萃取精華液;以及一析離步驟,係將該萃取精華液通過一 過濾設備,以濾除雜質,並降低有毒重金屬含 【圖式簡單說明】 -步揭示本案之具體技術内容’首先請參閱圖 式,其中,圖1為本案中草藥藥材萃取液製備方法之流 圖。 ί 【實施方式】 如圖1所示,基本上,本案之製備方法係由一提煉 驟1,一摻合步驟2,及一析離步驟3所组成。 前 質 述 I先將樂材經由篩選及清洗,以去除藥材表面之雜 唯此俱為中草藥提煉前之相同前置作業,纟此不擬贅 1春本案之中草藥藥材不以前述之巴西蘑蒜為限, 二:ΪΠ以冬蟲夏草、靈芝、金銀花、野疏、松芽或 ☆ ί:1ϊ藥為之,倶屬本案之範疇。而在提煉步驟1 11 m则以兩階段同時進行,其一為理 另一則為分餾化處理12,在此分別詳述如下· 該熬煉處理11係將篩選及清洗 蘑菇取一定量(1公斤)置於一容^ 糸材堵如巴西 :升)’隨即將容器置於加熱設備,例如瓦斯爐上進行加 ”,、*、後以—般熬煮中草藥方式進行熬煉,例如加熱至水Page 5 200538143 V. Description of the invention (3) The first extraction solution in which the element is soluble in water and the effective trace element is dissolved in the solvent, and the solvent is separated and the second extraction solution is extracted; a blending step, The first and second extraction liquids are mixed and stirred to obtain a homogenization = extraction essence; and an isolation step is to pass the extraction essence through a filtering device to filter out impurities and reduce toxicity Heavy Metal Contained [Schematic description]-Step by step to reveal the specific technical content of the case 'First, please refer to the diagram, of which, Figure 1 is a flow chart of the preparation method of Chinese herbal medicine extract solution. [Embodiment] As shown in FIG. 1, basically, the preparation method of the present case is composed of a refining step 1, a blending step 2, and an isolation step 3. In the foregoing description, I will first screen and clean the music materials to remove the impurities on the surface of the medicinal materials, but this is the same pre-operation before the extraction of Chinese herbal medicines. For the limitation, two: ΪΠ uses Cordyceps sinensis, Ganoderma lucidum, honeysuckle, wild sparse, pine bud or ☆ ί: 1 Peony, which belongs to the scope of this case. In the refining step 1 11 m, it is carried out in two stages at the same time, one of which is rational and the other is fractionation treatment 12, which are described in detail below. The refining treatment 11 series will screen and clean mushrooms to a certain amount (1 kg) ) Place in a container ^ 糸 material plug such as Brazil: liter) 'Then put the container on a heating device, such as a gas stove for adding, ", *, and then cook in the same way as a Chinese herbal medicine, such as heating to water

200538143200538143

五、發明說明(4) 沸騰後,開小火繼續熬煉2小時,使藥材内之有效成份儘 量溶解於滾水中,從而獲得(2·4公升)之第一萃取液A 熬煉後之藥材則可經由乾燥後,並研磨成粉末,而回 然0 而分顧化處理12亦將篩選及清洗後之相同藥材取一定 量(1公斤)置於一容器内,並添加適量的溶劑(5公升),較 佳為酒精》辰度2 0 %之酒,並將該内含藥材與酒的容器置於 一分餾設備中,俾於熱浴中進行分餾,使酒精分餾後,從 而獲得(3公升)之第二萃取液b。而分餾後之藥材亦經由乾 燥後,並研磨成粉末,而回歸自然。其中,為得到較佳^ 分餾效果,該分餾設備較佳係採真空分餾設備。 而本案另將藥材進行分餾化處理之優點在於,藥材並 不盡然所有微量元素皆溶於水,事實上,幾乎有3 5%以上 的中草藥是溶於溶劑(例如以酒精作為溶劑)中,只有6 5〇/〇 是溶於水中,以便析出有效的微量元素。 其中’該提煉步驟1中之水及溶劑在與藥材浸泡前, 均通過一小分子化處理1 3,以便將水形成小分子化,而增 加萃取液為人體消化系統所吸收之機會,並增加治療效 果。該小分子處理係採用德國Pl〇cher系統處理,其不僅 能令水小分子化並且能量化,此舉使得消化系統欠佳的人 士,亦可獲得最佳的吸收率。 摻合步驟2係將前揭之提煉步驟1所分別獲得之第一萃 取液A及第二萃取液B於另一容器中摻混,並經由攪拌,使 兩萃取液充分調和成一萃取精華液C。V. Description of the invention (4) After boiling, open a small fire and continue to cook for 2 hours, so that the effective ingredients in the medicinal material are dissolved in boiling water as much as possible, so as to obtain (2 · 4 liters) of the first extract A After drying, it can be ground into a powder, and then return to 0, and the treatment of chemistry 12 also put a certain amount (1 kg) of the same medicinal materials after screening and cleaning into a container, and add an appropriate amount of solvent (5 Liter), preferably alcohol> 20% alcohol, and place the container containing the medicinal materials and wine in a fractionation device, place in a hot bath for fractionation, and then fractionate the alcohol to obtain (3 Liter) of the second extraction liquid b. After fractionation, the medicinal materials are dried and ground to a powder, which returns to nature. Among them, in order to obtain a better fractionation effect, the fractionation equipment is preferably a vacuum fractionation equipment. The advantage of the fractional treatment of medicinal materials in this case is that not all trace elements of medicinal materials are soluble in water. In fact, almost 35% of Chinese herbal medicines are soluble in solvents (such as alcohol as the solvent), only 6 50 / 〇 is dissolved in water in order to precipitate effective trace elements. Among them, before the water and solvent in the refining step 1 are immersed with the medicinal materials, they are all treated with a small molecule 1 3 in order to form the water into small molecules and increase the chance of the extract being absorbed by the human digestive system and increase treatment effect. This small molecule processing system adopts the German Polocher system, which can not only make water small molecules and energy, which will make people with poor digestion system also get the best absorption rate. The blending step 2 is to mix the first extraction liquid A and the second extraction liquid B obtained in the previous step 1 of the refining step 1 in another container, and then stir the two extraction liquids to form an extract essence C through stirring. .

第7頁 200538143 五、發明說明(5) 析離步驟3係將摻合步驟2所獲得之萃取精華液c通過 一過濾設備,較佳係為一種内含過濾層及離子交換樹脂之 過濾器,以便將萃取精華液C内之懸浮雜質及重金屬,例 如鎘濾除與吸附,以增加萃取精華液之澄清度,並將有害 人體之重金屬降至安全含量的範圍内,以確保服用人的身 體健康,不必擔心重金屬之副作用。 最後將過濾後之萃取精華液c以250 °c的高溫殺菌爸滅 菌後,再經由一小分子化處理,即可直接裝瓶,而成為一 口服液。 疋以,經由本案之實施,其獲致之功效,犖犖大者,‘ 計有如下數端: (1)該提煉步驟係以熬煉及分餾化處理,使分別溶於 水及溶劑之有效微量元素溶於萃取液中,而提高有效成份 (2)該水及溶劑預先經由小分子化處理,使水形成小 士子化,此舉不僅有利於小分子水與微量元素結合,以: 高析取率^ ,同時,有益於人體消化系統之吸收。Page 7 200538143 V. Description of the invention (5) The separation step 3 is to pass the extraction essence c obtained by blending step 2 through a filtering device, preferably a filter containing a filtering layer and an ion exchange resin. In order to filter out suspended impurities and heavy metals such as cadmium in the extract essence C to increase the clarity of the extract essence and reduce the heavy metals harmful to the human body to a safe content range to ensure the health of the person taking it No need to worry about the side effects of heavy metals. Finally, the filtered extract essence c is sterilized at a high temperature of 250 ° c and then sterilized by a small molecule treatment, and then can be directly bottled into an oral solution. Therefore, the effect obtained by the implementation of this case, the larger one, has the following ends: (1) The refining step is processed by refining and fractionation, so that the effective traces are separately dissolved in water and solvents. The elements are dissolved in the extraction solution, and the effective ingredients are improved. (2) The water and the solvent are treated with small molecules in advance to make the water into a petite form. Take rate ^, at the same time, it is beneficial to the absorption of the human digestive system.

售ϋ亥兮捧看合ρΛ·之萃取精華液在經由析離步驟之過滤 後體中之懸浮雜質,並將有毒重金屬,, 如,安全含量之範圍内,而不必擔心有毒重金】所 向經濟部標準檢驗局檢二· 所得之萃取精華; 鎘UCP檢測方法)係未二(:广號碼為903〇2003 1 78)後, 在;另由國立台灣大學=可^出下限刚)的存 予嚴慶齡工業發展基金會合設工業;Selling the suspended impurities in the extract of ρΛ · extracted essence in the filtered body after the separation step, and selling toxic heavy metals, such as within the safe content range, without having to worry about toxic heavy gold] The Ministry of Standards and Inspection of the People ’s Republic of China • The extracted extract; the method for the detection of cadmium UCP) is after the second (: Canton number: 903〇2003 1 78); Yan Qingling Industrial Development Foundation co-founds industry;

200538143 五、發明說明(6) 究中心由環境品質檢驗室之樣品檢驗報告(檢驗編號為 E92A125D126)檢驗出鎘(Cd)為0.03 0 ppm,遠低於食品安 全含量的範圍内。 本案所揭示者,乃較佳實施例之一種,舉凡局部之變 更或修飾而源於本案之技術思想而為熟習該項技藝之人所 易於推知者,倶不脫本案之專利權範疇。 綜上所陳,本案顯示其迥異於習知之技術特徵,亦符 合發明之專利要件,懇請貴審查委員明察,並祈早曰賜 予專利’俾嘉惠社會,實感德便。200538143 V. Description of the invention (6) The research center tested 0.03 0 ppm of cadmium (Cd) from the sample inspection report of the environmental quality inspection room (inspection number E92A125D126), which is far below the range of food safety content. The one disclosed in this case is one of the preferred embodiments. Those who change or modify locally and derive from the technical ideas of this case and who are easy to infer for those skilled in the art, do not depart from the scope of patent rights in this case. To sum up, this case shows that its technical characteristics are quite different from the conventional ones, and it also meets the patent requirements of the invention. We ask your reviewing committee to make a clear observation, and pray that the patent will be granted early.

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200538143 六、申請專利範圍 1· 一種中草藥藥材萃取液之製備方法,其包括: 一提煉步驟’其係取定量之藥材置於兩容器内,並分 別添加適量的水及溶劑,而後各自經由一熬煉處理及一分 餾化處理’俾分別獲得有效微量元素溶於水之第一萃取 液,以及有效微量元素溶於溶劑,並將該溶劑分顧提析而 出之第二卒取液, 一摻合步驟,係該第一及第二萃取液混合,並經由攪 拌,而獲得一均質化之萃取精華液;以及 一析離步驟,係將該萃取精華液通過一過濾設備,以 濾除雜質,並降低有毒重金屬含量而成者。 2·如申請專利範圍第1項所述之中草藥藥材萃取液之 製備方法,其中該藥材係選自巴西蘑菇、靈芝、冬蟲夏 草、金銀花、野菰、松芽等之中草藥。 3·如申請專利範圍第1項所述之中草藥藥材萃取液之 製備方法,其中在提煉步驟之前,該藥材先行進行篩選及 清洗。 4·如申請專利範圍第1項所述之中草藥藥材萃取液之 製備方法,其中該溶劑係為酒精。 5·如申請專利範圍第4項所述之中草藥藥材萃取液之 製備方法,其中該溶劑係為酒精濃度為2〇%之酒。 6·如申請專利範圍第1項所述之中草藥藥材萃取液之 製備方法,其中該分餾化處理係在一真空分餾設備為之。 7 ·如申請專利範圍第1項戶斤述之中草藥藥材萃取液之 製備方法,其中該水及溶劑在與藥材浸泡前先經由一小分200538143 VI. Scope of patent application 1. A method for preparing Chinese herbal medicine extracts, including: a refining step, which takes a certain amount of medicinal materials and puts them in two containers, and adds appropriate amounts of water and solvent, respectively A refining treatment and a fractional distillation treatment are performed to obtain a first extract solution in which effective trace elements are dissolved in water, and effective trace elements are dissolved in a solvent. In the combining step, the first and second extraction liquids are mixed and stirred to obtain a homogenized extraction essence; and an isolation step is to pass the extraction essence through a filtering device to filter out impurities, And reduce the content of toxic heavy metals. 2. The method for preparing an extract of a Chinese herbal medicine as described in item 1 of the scope of the patent application, wherein the medicinal material is selected from the group consisting of Brazilian mushrooms, ganoderma lucidum, Cordyceps sinensis, honeysuckle, wild coriander, and pine buds. 3. The method for preparing an extract of a Chinese herbal medicine as described in item 1 of the scope of patent application, wherein the medicinal material is screened and washed before the refining step. 4. The method for preparing an extract of a Chinese herbal medicine as described in item 1 of the scope of patent application, wherein the solvent is alcohol. 5. The method for preparing an extract of a Chinese herbal medicine as described in item 4 of the scope of application for a patent, wherein the solvent is wine with an alcohol concentration of 20%. 6. The method for preparing an extract of a Chinese herbal medicine as described in item 1 of the scope of patent application, wherein the fractionation treatment is performed in a vacuum fractionation device. 7. The method for preparing Chinese herbal medicine extracts as described in item 1 of the scope of the patent application, wherein the water and solvent are subjected to a small fraction before being soaked with the medicinal materials. 第11貢 200538143 六、申請專利範圍 子化處理。 8. 如申請專利範圍第1項所述之中草藥藥材萃取液之 製備方法,其中該過濾設備内含過濾層及離子交換樹脂。 9. 如申請專利範圍第1項所述之中草藥藥材萃取液之 製備方法,其中該有毒重金屬係為鎘。 10. 如申請專利範圍第1項所述之中草藥藥材萃取液之 製備方法,其中該過濾後之萃取精華液經由一高溫殺菌釜 滅菌,再經由一小分子化處理,即可直接進行裝瓶。 ΟThe 11th tribute 200538143 VI. Patent application scope 8. The method for preparing an extract of a Chinese herbal medicine as described in item 1 of the scope of patent application, wherein the filtering device includes a filtering layer and an ion exchange resin. 9. The method for preparing a Chinese herbal medicine extract as described in item 1 of the scope of patent application, wherein the toxic heavy metal is cadmium. 10. The method for preparing Chinese herbal medicine extracts as described in item 1 of the scope of patent application, wherein the filtered extract essence is sterilized by a high-temperature sterilization kettle, and then processed by a small molecule, and then can be directly bottled. Ο 第12頁Page 12
TW93115297A 2004-05-28 2004-05-28 Method for preparation of Chinese herbal medicine extract TW200538143A (en)

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