TR201900131T4 - Lipozom Üretim Yöntemi Ve Lipozom Üretim Cihazı - Google Patents

Lipozom Üretim Yöntemi Ve Lipozom Üretim Cihazı Download PDF

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Publication number
TR201900131T4
TR201900131T4 TR2019/00131T TR201900131T TR201900131T4 TR 201900131 T4 TR201900131 T4 TR 201900131T4 TR 2019/00131 T TR2019/00131 T TR 2019/00131T TR 201900131 T TR201900131 T TR 201900131T TR 201900131 T4 TR201900131 T4 TR 201900131T4
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TR
Turkey
Prior art keywords
liposome
liposome production
tank
producing
circulation path
Prior art date
Application number
TR2019/00131T
Other languages
English (en)
Inventor
Sugiyama Susumu
Yamada Naoki
Sugiyama Shigehisa
Okubo Yohei
Original Assignee
Fujifilm Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujifilm Corp filed Critical Fujifilm Corp
Publication of TR201900131T4 publication Critical patent/TR201900131T4/tr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/40—Mixing liquids with liquids; Emulsifying
    • B01F23/41—Emulsifying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/20—Jet mixers, i.e. mixers using high-speed fluid streams
    • B01F25/21—Jet mixers, i.e. mixers using high-speed fluid streams with submerged injectors, e.g. nozzles, for injecting high-pressure jets into a large volume or into mixing chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/50—Circulation mixers, e.g. wherein at least part of the mixture is discharged from and reintroduced into a receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Manufacturing & Machinery (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

Burada, büyük ölçekli üretimde küçültülmüş bir lipozomun üretilmesine yönelik bir yöntem ve yukarıda bahsedilen yöntemde kullanılacak bir lipozomun üretilmesine yönelik bir aparat açıklanmaktadır. İçinde en az bir lipidin bir organik solvent içinde çözüldüğü bir yağ fazı ve birinci tank ve bir sirkülasyon yoluna sahip bir aparatın bir birinci tankında bir su fazını içeren bir karışımın karıştırılması adımını içeren bir lipozom üretilmesine yönelik bir yöntem sağlanır, burada sirkülasyon yolunun kapasitesinin tankın ve sirkülasyon yolunun toplam kapasitesine oranı, 0.4 veya daha azdır ve/veya karışımın, buradan boşaltılmasının ardından birinci taka geri dönmesi için gereken süre 2.0 dakikaya kadardır.
TR2019/00131T 2014-12-19 2015-12-18 Lipozom Üretim Yöntemi Ve Lipozom Üretim Cihazı TR201900131T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2014257282A JP6373749B2 (ja) 2014-12-19 2014-12-19 リポソームの製造方法及びリポソーム製造装置

Publications (1)

Publication Number Publication Date
TR201900131T4 true TR201900131T4 (tr) 2019-02-21

Family

ID=56126755

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/00131T TR201900131T4 (tr) 2014-12-19 2015-12-18 Lipozom Üretim Yöntemi Ve Lipozom Üretim Cihazı

Country Status (8)

Country Link
US (2) US10485760B2 (tr)
EP (1) EP3235561B1 (tr)
JP (1) JP6373749B2 (tr)
DK (1) DK3235561T3 (tr)
ES (1) ES2704549T3 (tr)
PL (1) PL3235561T3 (tr)
TR (1) TR201900131T4 (tr)
WO (1) WO2016098875A1 (tr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109261088B (zh) * 2018-10-11 2020-03-17 本溪恒康制药有限公司 制备脂微球的设备及制备方法
JP2022506097A (ja) * 2018-10-26 2022-01-17 ユニバーシティ オブ コネチカット ナノ粒子に対する内部修飾および外部修飾の連続処理システムおよび方法
CN109939575B (zh) * 2019-04-29 2024-06-18 河南卷烟工业烟草薄片有限公司 一种粉末聚丙烯酰胺溶解装置
CN109925956A (zh) * 2019-04-29 2019-06-25 苏州艾特森制药设备有限公司 一种实验室脂质体制备系统
WO2024086866A1 (en) * 2022-10-27 2024-05-02 Newsouth Innovations Pty Limited Method for producing and processing dynamic metastable polymersomes under continuous flow

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Also Published As

Publication number Publication date
US12005143B2 (en) 2024-06-11
US10485760B2 (en) 2019-11-26
DK3235561T3 (en) 2019-01-28
WO2016098875A1 (ja) 2016-06-23
ES2704549T3 (es) 2019-03-18
JP6373749B2 (ja) 2018-08-15
EP3235561B1 (en) 2018-11-14
PL3235561T3 (pl) 2019-06-28
US20170281543A1 (en) 2017-10-05
US20180133156A1 (en) 2018-05-17
EP3235561A4 (en) 2017-12-13
EP3235561A1 (en) 2017-10-25
JP2016117669A (ja) 2016-06-30

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