TR201313845A2 - Potansiyel ön ilaçlar olarak bazı nonsteroidal antienflamatuar ilaçların amit türevlerinin sentezi. - Google Patents

Potansiyel ön ilaçlar olarak bazı nonsteroidal antienflamatuar ilaçların amit türevlerinin sentezi. Download PDF

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Publication number
TR201313845A2
TR201313845A2 TR2013/13845A TR201313845A TR201313845A2 TR 201313845 A2 TR201313845 A2 TR 201313845A2 TR 2013/13845 A TR2013/13845 A TR 2013/13845A TR 201313845 A TR201313845 A TR 201313845A TR 201313845 A2 TR201313845 A2 TR 201313845A2
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Turkey
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ipan
iil
mit
presented according
drugs
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TR2013/13845A
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English (en)
Inventor
Kulabaş Necla
Set İrem
Küçükgüzel İlkay
Original Assignee
Ilkay Kuecuekguezel
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Priority to TR2013/13845A priority Critical patent/TR201313845A2/tr
Priority to EP14188019.5A priority patent/EP2878592B1/en
Publication of TR201313845A2 publication Critical patent/TR201313845A2/tr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
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    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
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    • C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
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    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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    • C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
    • C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
    • C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
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    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
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    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D491/04—Ortho-condensed systems
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    • C07C2601/14—The ring being saturated

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Abstract

Mevcut buluş NSAİ ilaçların GI (Gastrointestinal) sisteme olan zararlarını önlemek ya da azaltmak amacıyla NSAİ ilaçlarda bulunan asidik grupların maskelenmesi için bir yöntem sunmaktadır. Geçiştirilen yöntem temel olarak NSAİ ilaçlara ait karboksilik asit gruplarının metil esterifikasyonuna maruz bırakılması ve akabinde amitlenmesi suretiyle yeni amit türevlerinin oluşturulmasını içermektedir. Buluş ayrıca ön ilaç olarak kullanıma uygun yeni NSAİ ilaçların amit türevlerine ilişkindir.

Claims (4)

ISTEM LER Eii' kai'hi'iiksilili asit pi'uhu ihti'i-a eden bir NEAI ilaein amit rüi'e'i-lei'ini üretmek; uieie hii' yöntem i'iilup öielligi: sü: liii'iinusu yöntemin', bahsi geçen karlmksilili asit gi'uh-unun hii' metil estei'inin elmui'ulmaisi: 'i-e hu metil estei' yapisinin amitlenmesi sunetiyle HEAI amit tüi'ei-inin eliie edilmesi adimlarini ihti'i-a e'imesiiiiii'. Istem l`e göre sunulaii bir yöntem i'iilup özelligi kai'heksililii asit gi'uhunun metani'iil ile muamele edilmesi sureti ile metil estei'inin elde edilmesi ai:limini ihti'i-a etmesiiiiii'. Istem l`e göre sunulan ;i-iîntem elup özelligi: sü: lii'iinusu metil estei' yapisinin asagidaki Fei'mül -[l]i`i haiiti'isühstirîie melanamin ile amitlenmesi aiiimini inti'i-a etmesiiiiii': Istem l`e göre sunulan bir yöntem elupiîzelligi: HEAI ilacin karhii'iiksilili asit pi'uhunu tasiyan Fi'iii'mul {ll]i`;ue sahip bir ai'ilpi'i'iipiiiii'iinilci asit gi'uhunu ihtii-a etmesiiiiii': Istem J`e göre sunulan yöntem i'iilup fiiielligi elde edilen amit tüi'e'i-inin hii' pi'i'iipana mit tüi'e'i-i elmas iiiiii'. Islam 4`i: göre sunulan yöntem i'iliip faalligi af:: küllLLîlLl NSAI ilacin Dclülicti'iiprafcii Ibupri'iifcn veya Flurhipri'ifcn i'iilriiasiiizlir. Bir HSAI ilacin artiit türevi i'iilLip faalligi asagidaki fi'iirriiüllcrdian birini ihtiva 2-[2-{=i-H li'iiri'iifanil1i-lj-bciii'i'ilüaml-S-il]-i'|i'-[ lj-dihiiiri'ilüi-E {hiiiiri'iik_r.iriii:til]i pmpan-E-il]pri1panartiit .'Ii'-[ lj-Dihidri'ikai-E-miiiri'iks. imatil1ipri'ipan-2- il]-214'-difli'iri'i-*I-hiiiri'ikaibifaiiil-I- karbi'iilüariiit 2-l2-[{2,Eih[:likli'iiri'iifaiiil1iar'iiiiii'ii]fanil :i-.'Ii'-[ lj-dihiizlri'iikai-E-lî hidri'iikair'iiatilmri'ipan- 2-il]a.r.ii:tariiit 2-{ lsH-Diatil-IJsLQ-tatra hidri'ipiraiii'i[3s=i-i'ii]iiiiial-l- il]i-i'i.i'-[ lj-dihiiimlü. i-E- {hiiiri'iilL=.i milhmpan-E-ilhsiatamit 2-[2-{2 4-Dilili'ii ri'iifcni'iilisi]il"c nil]-.'Iii'-[ lJ-dihiiiri'ilar. i-2-[ hidri'iilüiriiatilhmpan-E- il] aricta mit .'Ii'-[lj-Dihidmhai-E-iîhidmkairtictil1ipri'ipan-2-il]-2--[3-fii3ni'iik_~*.ifciiil1ipri'iipanamit .'Ii'-[ lj-[Iihidri'ilüi-24hiiiri'ilü. imatil1ipri'ipan-2- il]-2- { [E-rmt il-3-{trifli'iir'i'iirtiatil]ifi3nil] amini'iilpiriiiin-S-liarhi'iüa mit i'Ii'-[ lj-Dihidmhai-E-iîhidmkaimctilmri'ipan-E-il]-2--[2-fli'iri'il:iifciiil-1-il]ipri'iipanariiit .'Ii'-[ lj-[Iihidri'ilüi-24hidri'ilü. imatil1ipri'ipan-2- il]-2--[-*I-i1'i'iil:rüt ilfani l]ia5ii:ta riiit .'Ii'-[ lJ-Dihidri'iilüi-E-lîhiiimlü.irtictil1iprii'iipan-2-il]-2--[=1-i::i'iil:iütilfciiil1ipri'iipanariiit 2-[ l-{=i-I=lli'iiri'iil:ii:i12i'iiil]i-:'i- rtiati'ilLqi-E-riiatil-lH-iniii'iil-E-il ]-.'Ii'-[ lJ-dihiiiiri'iilü. i-E- {hiiiri'iik_=.i milmmpaii-E-ilpmtamit .'Ii'-[ lj-[Iihiiiri'iilü i-2-{hiiiiri'iik_r. ir'iiatil1ipri'ipan-2- il]-2- rmtil-E-[sH l-i'ilLqi'ii-Ej-dihiiiri'i- lH-ia'i'iiiiiiii'il-E-il]ifanil]a.rii3tamitII] 2-{3-l3ii±i12inllfc i1'il]i-J r-[ lj-iiiihidmk.:l-2-{hldmk_qimctil]ipmpm1-2-il]pmpmm mit {2IE'}-2-{3-l3citztiilfci1ll]i-J r-[ l j-dlhldmk.:i-2-{ hidri'ikj'imct 'Lwl-np& ii-E- EFE lam-.MH lJ-dlMiiimLqu-E-{ hidmlqu met 'il }pmpm1-2-`il]- 5-5 üclii'iihii: kil [-25- dihidm-lH-liidcii-l-kairhiniünmit 2-[{3-H li'iirii'ii-E-rtiiit'il fciillhmiim]-J'Ii'-[ lj-dihldmkj I-E-{hlii:ll'ükj immllhmpnii-E-il] pir'uii i1-3-kmhnkaamit 2-[ l-{=I-I=Lli'imfci1il]i-2j-dlmi:tl l-thp'iml-J-'il ]-J'Ii'-[ lj-dlhldmkji-E-miiimkjl mutlu pmpnii-E-ilmcm rti'it .'i.'.[ lj-Dihidmksi-E-ifhldmkj lmmllwmpaii-E- ii]_2- [4125- dimtilfciiilhmiimßcim mit 2-[{2 Ei-EI iklii'ii rti-S-nietllfciillhmiim]-N-[ lj-dihldmkai-2-1Çhidmmimmilwmpm-E- il] hcimmit S-Am'iiu'ii-J'H ISE-dihldmlü.i-2-{h'u:lri'ik_~1imi:til]ipmpm1-2-il]-2-hidmk_aibcimmit .'Ii'-[ lj-Dihldmkal-E-mldmkj lmctilßrnpnii-E- il]-2- { [3-{trlf1nmmctll]ifci1il] amiimSplrLdlii-S-kmhnkm mit 3-{4s5-[Ilfci1ll-lj-i'iikjaml-E-ll]i-J'Ii'-[ lj-dihliimkql-24hidmlülrmtilmmpmi-E-ll] 3J'-Diaizci1-I.,2-dülbû 1'fi-h'iiiimül-;NLE-hidmkjl-L I-bLiîil'h'Liiirii'iiül milhtilwcim mü:i 2-[3-H. MWESS-dlhim'n-IH-plml-l-ll ]ifii:i1'il]-J'Ii'-[ l j-dihidmk.:l-2-{ h'uii mkjlmct ll]i pmpaii-E-ll]pmpmmmit 2-i [idmkj'L-hqlj-dihidmk.:l-2-{hidmk.:irti:til}pmpm1-2-il]-S-{ H-[{p`irlii:lli1-2- ilamlim]i aülfciiiil]fci1il :-dLizciiiUhcim-imlt 2-{{ l..?]i- S-Fli'ii m-E-rtiatil-l-[H rt'iatilsülfiiiil]ii:iai12iliii:laii]-IH-ii1iiiai1-3-il :i-.'Ii'-[ L3- dihiiiraksi-2-{hidri'iiksirtiistil1iprapai1-2-il]asi:tamit .'Ii'-[ lJ-Dihidmiasi-E-iîhidmias imatilhmpaii-E- il]-2- [HE-tiyaiiilkarhiaiii l]ifii:i1il] pmpaiiamit 2-{S-l3ii:i12i'iiil-2-ti3ii:i1il]i-i r-[ lJ-dihidmiasi-E-1I hidmiasimatilhmpan-E-ilmmpanamit 2-[{3-H lara-E-mistil faiiilhmiim]-.'Ii'-[ lJ-dihidmks i-2-{hiii:lri'iiiLs imatil1ipriapaii-2-il] hciua mit .'Ii'-[ lj-Dihidmksi-E-midmksimatilhrapaii-E-il]-2-[ l-rtiatil-S-{-
1-rtiatilhaiizail]i- lH-piral-E-il]asatartiit
2-[ S-H-Hlamhcni'a il]i-lsd-diniatil-lH-piral-E-il]-J'Ii'-[ lj-dihiiiiraksi-E- {hiiiiri'iiksirtiati l]i prapaii-E-i l]asiata mit Istam Ty:: göre sunulan bir Nil-!LI artiit türevi i'iilLip &ralligi sf:: ki'iiiiusu HEM tümwiiiiii asagidaki genel farmül [lb]`3.iii: sahip 2-{
3-baiuailfciiil]i-T~i-[l.,3- dihidri'iiks i-E-[ hiiiiri'iiLsi metin-p mpan-E-il]pmpanam it almasi siir: Kafkas“ i* Istam ?ya göre sunulan bir HEAI artiit türevi i'iilup özelligi sü:: kaiiusu NEAI tümuiiiiii asagidaki genel I'i'iirmül [21:]'313 sahip .'Iii'-[l,3-dihiiiirii'iiksi-2- -[hidraksirtiatil}prapan-2-il]-2-[=I-i1i'iii:ûtilfaiiilhmpaiiamit almasidir: .i' Lxllufi i. "1: _H istem Ty:: göre sunulan bir Hill-!LI artilt türevi alup faalllgi af:: kaiiuau HEM tül-evinin asagidaki gciml farmül [31:]'yc sahip .'Ii'-[l,_3-DihliiralL=.l-2- {hldrak=.lmctll]ipmpan-2-ll]-2-[2-f1ariahifciiil
4-il}pmpmmmit bllcs'igl alniaaiiiiir:
TR2013/13845A 2013-11-27 2013-11-27 Potansiyel ön ilaçlar olarak bazı nonsteroidal antienflamatuar ilaçların amit türevlerinin sentezi. TR201313845A2 (tr)

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EP14188019.5A EP2878592B1 (en) 2013-11-27 2014-10-07 Synthesis of amide derivatives of some nonsteroidal antiinflammatory drugs as potential pro-drugs

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